title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Induction of oocytic maturation and differentiation: mode of progesterone action. | Full-grown amphibian oocytes, arrested in prophase I or meiosis, respond in vitro to progesterone and certain other steroids. They undergo an apparently normal sequence of nuclear maturation and cytoplasmic differentiation, which are necessary precedents for fertilization and embryogenesis. Individual oocytes or popula... | 363,020 | [
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Isolation and identification of yeast messenger ribonucleic acids coding for enolase, glyceraldehyde-3-phosphate dehydrogenase, and phosphoglycerate kinase. | Yeast poly(adenylic acid)-containing messenger ribonucleic acid isolated from two strains of Saccharomyces cerevisiae was fractionated by preparative polyacrylamide gel electrophoresis in the presence of formamide. Three messenger ribonucleic acids, present at high intracellular concentration, were electrophoretically ... | 363,146 | [
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Specific interaction between mouse liver non-histone chromosomal proteins and mouse DNA demonstrated by a sequential DNA-protein binding procedure. | The binding of mouse liver chromosomal proteins to DNA has been investigated using the nitrocellulose filter binding technique. Careful purification of the DNA involving nuclease S1 digestion and prefiltration through a nitrocellulose filter is used to reduce background binding in the absence of protein to less than 1%... | 363,155 | [
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A large nucleoprotein fragment of the 50-S ribosomal subunit of Escherichia coli. | A large nucleoprotein fragment was isolated from a nuclease digest of Escherichia coli 50-S ribosomes and purified to gel electrophoretic homogeneity. Conditions were employed under which the fragmentation pattern was reproducible and the various fragment fractions were stable and maintained their sedimentation and ele... | 363,160 | [
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Studies on the carboxypeptidase Y-inhibitor complex of yeast. | We report in vitro studies on the interaction of several substrates with the carboxypeptidase Y-inhibitor complex of yeast. Inhibition of carboxypeptidase Y cleavage of two peptides by carboxypeptidase Y-inhibitor is shown to be competitive. The experiments show a wide variation in the degree of cleavage of a variety o... | 363,166 | [
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[Effect of serum fractions from cancer patients on leukocyte migration out of capillary tubes]. | Blood serum of patients suffering from cancer of the stomach and urinary bladder inhibited in vitro migration of autologous leukocytes, leukocytes of donors and control patients, and also guinea pig macrophages in over half of cases. In chromatography of these sera on Sephadex G-100 the activity inhibiting the leukocyt... | 363,203 | [
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Metronidazole prophylaxis for elective large bowel surgery in children: a prospective trial. | In a controlled trial in children aged 2 days to 16 years undergoing large bowel surgery a group of 15 patients had preoperative mechanical bowel preparation and oral neomycin while a second group of 15 patients was similarly prepared but also had preoperative and postoperative metronidazole medication. Five of the 9 p... | 363,217 | [
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Processing of rRNA by RNAase P: spacer tRNAs are linked to 16S rRNA in an RNAase P RNAase III mutant strain of E. coli. | To determine which enzymes are responsible for the processing cleavages of ribosomal RNA transcripts in Escherichia coli, we constructed a mutant strain lacking RNAase III and containing a thermolabile RNAase P. At the nonpermissive temperature, this strain accumulates a novel "19S" RNA species which contains 17S precu... | 363,277 | [
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The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. | A method has been developed to measure local glucose consumption in the various structures of the brain in man with three-dimensional resolution. [18F]-2-deoxy-2-fluoro-D-glucose is used as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissue. A mathematical ... | 363,301 | [
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Membranous glomerulonephritis associated with anti-tubular and anti-alveolar basement membrane antibodies. | The renal biopsy of a 3-year old boy with complete Fanconi syndrome showed the association of a membranous glomerulonephritis with severe tubulointerstial changes. Immunofluorescence microscopy disclosed linear and granular deposits of Ig along tubular basement membranes. The presence of anti-tubular basement membrane ... | 363,319 | [
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Androgen therapy of aplastic anaemia. | The current published reports have indicated that the young patient with aplastic anaemia who has a compatible marrow donor can obtain a successful marrow graft, especially if sex matched and with a past record of little or no transfusion therapy. Despite these encouraging results, only a small number of patients will ... | 363,329 | [
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Inhibition of ovulation in women by chronic treatment with a stimulatory LRH analogue - a new approach to birth control? | A stimulatory luteinizing hormone-releasing hormone (LRH) analogue D-Ser (TBU)6-EA10-LRH was administered subcutaneously once daily in a dose of 5/microgram to four regularly menstruating women. Treatment was instituted within the first three days of the menstrual bleeding and continued for 22--30 days. Ovulation was i... | 363,344 | [
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Optimal flow pattern for mechanical ventilation of the lungs. 2. The effect of a sine versus square wave flow pattern with and without an end-inspiratory pause on patients. | In four series of patients, the efficiency of ventilation of a sine wave without an end-inspiratory pause was compared to a square wave without a pause, a sine wave with a pause to a square wave with a pause, a sine wave to a sine wave with a pause, and a sine wave with a long pause to one with a short pause. The prim... | 363,355 | [
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Drip breast milk: it's composition, collection and pasteurization. | "Drip breast milk" is that milk which spontaneously drips from the contralateral breask during the suckling of an infant. Biochemically and immunologically, pooled drip milk resembled pooled mature expressed breast milk, although it has a lower fat concentration. About 15% of lactating women are capable of producing dr... | 363,402 | [
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Autonomic innervation of the heart. | This brief review describes recent advances in the areas of myocardial receptors that discharge into nonmyelinated, afferent, vagal C-fibers and the regional distribution of sympathetic postganglionic neurons to the myocardium. Complex, nonencapsulated nerve endings discharging into myelinated afferents have been known... | 363,413 | [
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Ultrastructure of heart muscle. | The ultrastructure of cardiac muscle is described. In the course of the descriptions advantage has been taken of comparative anatomy, in order to elucidate the relationships between structure and function. Physiologic parameters are discussed in a comparative manner including information from skeletal muscles fibers th... | 363,414 | [
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Rapid purification of plasmid DNAs by hydroxyapatite chromatography. | A method is described for the rapid preparation of plasmid DNAs of molecular weight up to 14 X 10(6). This method involves the chromatography, at room temperature, of bacterial cleared lysates on hydroxyapatite in the presence of high concentrations of phosphate and urea. All detectable protein and RNA contamination of... | 363,426 | [
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Functional alteration of islet cells after jejunal or ileal resection in dogs. | Functional alteration of the islet cells was investigated in dogs after the resection of different parts of the small intestine. Three weeks after jejunal or ileal resection, when the dogs might still have been in a catabolic state, insulin and pancreatic glucagon release in response to intravenously infused glucose an... | 363,491 | [
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[Transmission of F'lac plasmid from Escherichia coli K-12 to bacteria of the genus Erwinia]. | The F'lac plasmid was transferred by conjugation from Escherichia coli K-12 W1655 to 21 lac- strains of Erwinia spp. (5.2 . 10(-6) to 6.8 . 10(-2) lac+ exconjugants per donor cell). Erw. herbicola and Erw. chrysanthemi were the better recipients than others. The degree of the stability of lac+ genes in Erwinia exconjug... | 363,511 | [
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Construction and characterization of new cloning vehicles. III. Derivatives of plasmid pBR322 carrying unique Eco RI sites for selection of Eco RI generated recombinant DNA molecules. | In vitro recombinant DNA techniques were used to construct two new cloning vehicles, pBR324 and pBR235. These vectors, derived from plasmid pBR322, are relaxed replicating elements. Plasmid pBR324 carries the genes from pBR322 coding for resistance to the antibiotics ampicillin (Apr) and tetracycline (Tcr) and the coli... | 363,519 | [
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The private initiative in PSRO. | Private Initiative in Professional Standards Review Organizations (PIPSRO), a privately funded project sponsored by four major health care associations, has developed principles to guide the formulation of the respective responsibilities of HEW and the private sector in regulating quality assurance. The management comm... | 363,596 | [
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Purification of antigen-dependent macrophage migration inhibition factor (MIF) from lymph draining a tuberculin reaction. | An antigen-dependent factor showing migration inhibition (MIF) and gold uptake stimulation (GUS) activities which has been previously described (Lowe & Lachmann, 1974) has been further purified from efferent lymph collected from cannulated nodes of BCG-sensitized sheep undergoing a delayed hypersensitivity response... | 363,599 | [
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[Closure of facial defects using full-skin transplants from the face]. | Full thickness skin grafts from inner or outer areas of the face to cover defects in the face following tumor excision achieve functional and cosmetic results comparable to those methods using flaps. In contrast to this method grafting of full-thickness skin can be performed under local anesthesia on an out-patient bas... | 363,651 | [
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Microbiological method for assaying lincomycin in animal feed: collaborative study. | A microbiological assay for determining lincomycin in swine feed, supplement, and a vitamin-mineral premix was studied collaboratively in 16 laboratories. The design of the study involved a complete feed, feed supplement, and a vitamin-mineral premix covering a range of fortification from 20 to 80 g/ton and 80 to 2600 ... | 363,677 | [
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HindII and HindIII restriction maps of the attphi80-tonB-trp region of the Escherichia coli genome, and location of the tonB gene. | The HindII and HindIII restriction maps of the attphi80-tonB-trp region of the Escherichia coli chromosome are presented. Analysis of phage DNAs carrying tonB mutations has allowed identification of a 1,730-base pair HindII fragment containing at least part of the tonB gene. This fragment is 4,020 base pairs from the e... | 363,691 | [
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Fibroblasts and macrophages of mice with the Chediak-Higashi-like syndrome have microtubules and actin cables. | Cells of the beige mouse contain abnormally large lysosomes and show enhanced capping of concanavalin A. It has been suggested that these phenomena may be secondary to a defect in microtubule polymerization. We have examined the cytoskeleton of beige mouse cells by indirect immunofluorescence and find the number and di... | 363,727 | [
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Heated versus unheated sera in a microhemagglutination assay for antibodies to Treponema pallidum. | The effect of prior heating of sera on the results of the microhemagglutination assay for antibodies to Treponema pallidum was evaluated. Findings indicate that heating of sera had no significant effect on the results. | 363,746 | [
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A technique for the removal of junctional epithelium from the epithelial attachment. | A technique utilizing sodium deoxycholate to remove junctional epithelial cells from the epithelial attachment zone is described. Light and electron micrographs show a similarity in size and appearance between the extracellular attachment substance in controls and the extracellular substance which remains on cementum p... | 363,757 | [
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0.08395425,
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0.03478689,
... |
Detection of tubulin and actin in various cell lines by an immunoperoxidase technique. | This paper reports on the preparation of immunsera against tubulin and actin, and the purification of anti-tubulin and anti-actin antibodies on immunoadsorbent columns. These purified antibodies were used in an indirect immunoperoxidase assay to visualize microtubules and microfilaments in various cell lines. The speci... | 363,933 | [
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Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. | Two unusual murine lymphomas, designated CH1 and CH2, were produced in the newly developed double congenic strain of mice, B10 H-2a H-4b p/Wts. Both tumors lack the T cell-specific antigen (thy-1), but express cell surface immunoglobulin and the H-2K, H-2D, and Ia specificities determined by the H-2a haplotype. Further... | 363,945 | [
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Colchicine induces multiple axis formation and stalk cell differentiation in Dictyostelium discoideum. | Colchicine is shown to have several effects on the development of the pseudoplasmodia of the cellular slime mould Dictyostelium discoideum. At concentrations of 0.01 M and above culmination was prevented, while differentiation of cells into stalk cells occurred at the rear of cell masses. Essentially all cells transfor... | 363,970 | [
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Review of in vitro systems with potential for use in teratogenicity screening. | In this review an in vitro system is considered to be any developing tissue, organ, or organism other than mammalian embryo in situ. Before the various test systems that have been used or proposed are discussed, attention is given to the questions of whether all chemicals in the environment are in need of biological te... | 363,968 | [
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Somatic O-1 antigen conversion of Salmonella typhimurium by a type B phage P221dis, hybrid between P22 and Fels 1 phages. | A type B Salmonella phage P221, derived from recombination between a type A phage P22 and a type B phage Fels 1, carries the protein coat of Fels 1 and the P22 early genes, at least the c to h21 genes. One of the P221 strains, P221dis, is dismune over P221 lysogens and co-immune with P22. Thus it carries the Im gene (t... | 363,976 | [
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Review of factors contributing to dry socket through enhanced fibrinolysis. | Use of oral contraceptives and trauma during extraction are substantiated factors that contribute to dry socket. They appear to act by enhancing fibrinolytic activity in the alveolar bone followed by lysis of the clot. The influence of bacteria and antibiotics on the development and prevention of dry socket remains unc... | 363,986 | [
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Antidiuretic action of intravenous and intracerebral pyrogen in conscious rabbits. | 1. In conscious rabbits an i.v. infusion of 30 or 60 microgram E. coli pyrogen/kg body wt. decreased urine flow from control of 1.13 +/- 0.11 (S.E. of mean) ml./min to 0.43 +/- 0.09 ml./min while urine osmolality increased from 212 +/- 16 to 679 +/- 82 m-osmole/kg H2O. Clearances of exogenous creatine and p-aminohippur... | 364,008 | [
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Performance criteria in preclinical denture prosthodontics. | This article has reported on a preliminary study of selected criteria used by The University of Michigan, School of Dentistry Complete Denture Department. Self-evaluation opportunities by students and assessment of performance by instructors using objective criteria have been developed for each phase of complete dentur... | 364,016 | [
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0.3553117... |
Articulator-generated amalgam stops for complete dentures. | Balanced occlusion in eccentric positions for complete denture occlusion is an acceptable and widely practiced concept. Many methods have been described for achieving balanced occlusion. The technique outlined in this article uses amalgam stops generated on a programmed Hanau Model H2 articulator. The posterior occlusa... | 364,033 | [
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Effects of an LH-RH analogue in male rats pretreated with oestradiol benzoate. | Treatment of adult male rats with oestradiol benzoate (OB) for 21 days significantly decreased the body, testicular and accessory sex organ weights but increased anterior pituitary weight. OB treatment also significantly suppressed circulating FSH and LH levels as well as plasma and testicular concentrations of testost... | 364,051 | [
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Synthesis of growth hormone by bacteria. | A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods. | 364,320 | [
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Cervical-vaginal flora of women with invasive cervical cancer. | The cervical-vaginal flora of 21 women with invasive cervical cancer was determined. The cultures yielded polymicrobial growth with anaerobic organisms predominating. As compared with other studies of vaginal flora, the cancer patients were found to have a decreased frequency of isolation of aerobic lactobacilli, Staph... | 364,358 | [
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Immunohistological approach to tumor diagnosis. | Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal ... | 364,360 | [
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Multiple endocrine neoplasia, type 2b. | Multiple endocrine neoplasia, type 2b, is a disorder of unknown etiology with major involvement of the thyroid and adrenal glands, the autonomic nervous system, and connective tissue. It is transmissible with an autosomal dominant pattern of inheritance, but since most cases are not familial, they presumably represent ... | 364,372 | [
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Epithelial migration in organ culture. A morphological and time lapse cinematographic analysis of migrating stratified squamous epithelium. | The migration of stratified squamous epithelium in organ cultures of rat palatal explants has been studied using scanning and transmission electron microscopy. The scanning microscope revealed plate-like folds at the margins, and microvilli on the bodies of cells. These structures were most highly developed on those ce... | 364,387 | [
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The tissue reaction to implanted foreign bodies in levan-treated mice. | The effect of local administration of levan on the reaction to foreign bodies was studied in the subcutaneous tissues of mice implanted with sterile cotton wool pellets or Melenex plastic coverslips. Treatment with levan reduced leucocytic invasion of the implanted pellets as well as the vasoproliferative response of t... | 364,388 | [
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Histochemical identification of T and B areas in paraffin-embedded lymphoid tissues by demonstration of alpha-naphthyl acetate esterase (ANAE) activity. | A strong activity of acid alpha-naphthyl acetate esterase (ANAE) in T lymphocytes and macrophages within mouse lymphoid organs is demonstrable even after paraffin-embedding, if a rapid embedding procedure with acetone as dehydrating agent is used. The lymphoid tissue structure is better preserved in paraffin sections p... | 364,446 | [
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Naturally occurring promoter down mutation: nucleotide sequence of the trp promoter/operator/leader region of Shigella dysenteriae 16. | The promoter/operator/leader region of the trp operon of Shigella dysenteriae 16 has single base pair differences from the corresponding region of Escherichia coli at positions -24 and -13. The difference at -13 was shown to be responsible for the 90% reduction in promoter function characteristic of the trp operon of S... | 364,484 | [
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Evidence for translocation of DNA sequences during sea urchin embryogenesis. | Hairpin-like DNA was prepared in vitro from the family of sequences that are inverted relative to each other and, as pairs, are relatively homologous and adjacent on the sea urchin genome. The majority of these hairpins are shown to have base pair mismatch positions distributed along their stems. Comparison of the hair... | 364,486 | [
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... |
Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitro. | A calcium sequestering platelet membrane fraction was prepared and the effect of arachidonic acid, PGG2 and PGH2 on calcium content evaluated. At 4 degrees C, 6.7--16.7 micrometers arachidonic acid caused significant release of calcium from preloaded vesicles. Such release was completely inhibited by aspirin pretreatin... | 364,508 | [
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Stability of authentic PGI2 during routine extraction. Clarification of the nature and sequence of products formed by the rat stomach including the origin of the ozonolysis products reported in 1971. | Authentic PGI2 and PGI2 formed by rat stomach homogenates were carried through a simple extraction and purification procedure to explore the feasibility of isolation of this biologically active bicyclic ether product of arachidonic acid. The integrity of PGI2 was followed throughout by bioassay on the rat blood pressur... | 364,546 | [
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Experimental Salmonella typhimurium infection in calves. | The paper describes the clinical, bacteriological and pathological findings in experimental Salmonella typhimurium infection in calves. Oral doses of 10(8) and 10(9) organisms produced clinical disease and high mortality; doses ranging from 10(4)--10(7) organisms were less consistent in their action. Jersey calves appe... | 364,573 | [
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The quantitative assessment of mucosa in canine small intestinal malabsorption. | Histological sections from the small intestines of dogs showing clinical signs of small intestinal malabsorption have been examined using morphometric techniques. Weibel graticule measurements appear to be a useful adjunct to the subjective assessment of villus atrophy. Severe clinical signs of small intestinal malabso... | 364,575 | [
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Tolerance breaking by lymphocyte activating factor induced by Escherichia coli O138 lipopolysaccharide from homologous macrophages. | Following an antigenic dose of 10 microgram or a tolerogenic dose of 200 microgram of Escherichia coli O138 lipopolysaccharide (LPS), BALB/c mice were examined on day 14 for percentages of theta-bearing cells. A considerable increase in T cells was noticed in lymphocytes from tolerant draining lymph nodes, and furtherm... | 364,578 | [
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Inflammation in osteoarthritis. | Osteoarthritis is usually regarded as a non-inflammatory disease. However, several authors have stressed the importance of an inflammatory phase early in the development of the condition, and specific inflammatory types of osteoarthritis have been described. Comparative trials of pure analgesic and anti-inflammatory dr... | 364,613 | [
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Anti-fibrinolytic therapy of giant hypertrophic gastritis (Menetrier's disease). | In five cases of giant hypertrophic gastritis (Menetrier's disease) biopsied gastric mucosa was examined for fibrinolytic activity; in all cases there was marked elevation of the activity due mainly to tissue plasminogen activator. The patients were given antifibrinolytic therapy with oral tranexamic acid (trans-4-amin... | 364,627 | [
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Vascular function in kidneys preserved by simple cold storage in Sacks' or Collins' solutions. | Vascular resistance was determined in 40 kidneys after preservation in Collins' or Sacks' solution for 24 and 48 hours. Kidneys without warm ischaemia and kidneys with up to 60 min of warm ischaemia prior to preservation were investigated, vascular resistance was determined during short time perfusion with Tis-U-Sol at... | 364,634 | [
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... |
The inhibitory effect of aspirin on human endothelial cells. | Human endothelial cell monolayers prepared from umbilical veins have been incubated with aspirin (1--2 mM) dissolved in Hepes modified solution and in platelet-rich plasma. They have also been incubated with plasma prepared from subjects before and after intake of aspirin giving a mean plasma concentration of 0.5 mM. T... | 364,762 | [
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0.5436946,
0.3148115,
0.1531117,
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-0... |
The effect of ICI 55,897 and clofibrate on platelet function and other tests abnormal in atherosclerosis. | There is considerable evidence that the quantity or quality of plasma lipids influences platelet function tests, and clofibrate reduces high plasma lipids and alters some platelet tests. Clofibrate was accordingly given to patients with vascular disease who were at risk of thrombosis. The heparin thrombin clotting time... | 364,763 | [
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[The value of direct localization studies for the surgical treatment of urinary tract infections (author's transl)]. | Techniques to localize an upper urinary tract infection--the bladder wash-out test and the ureteral catheterization method--are described. Case reports are given to demonstrate the usefulness of these methods when surgical treatment of urinary tract infections seems to be indicated. | 364,808 | [
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0.06665508,... |
[Surgery of genuine Perthes' disease (author's transl)]. | 134 children between 3 and 13 years of age (average age 6.4 years) were treated at the Orthopaedic Clinic of the Karl-Marx-University at Leipzig between 1955 and 1977, for genuine Perthes' disease. The treatment consisted of bolting the capitular epiphysis (head) of the femur with a homologous bone chip. Anatomical hea... | 364,858 | [
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... |
Chemotactic activity of polymorphonuclear leukocytes to Streptococcus pyogenes. | Influence of two different streptococcal group A type 12 strains on chemotactic activity of polymorphonuclear leukocytes (PMN) was investigated in vitro and in vivo. The strains differed only in presence of M protein. In both conditions, the inhibition of the chemotaxis of the PMN after their treatment with M positive ... | 364,883 | [
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0.0023578... |
[Occurrence of Aspergillus fumigatus in West Berlin - contribution to the epidemiology of aspergillosis (author's transl)]. | The increasing incidence of human A. fumigatus infections particularly such of the respiratory tract has led to this study of the epidemiological situation. During the period between October 1968 and December 1977, A. fumigatus was isolated from clinical material in 425 cases. These findings which were established at t... | 364,887 | [
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0.4091966,
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Diagnostic cytologic sample profiles in patients with bladder cancer using TICAS system. | Computer analysis of digitized cell images was applied to consecutively encountered, well preserved urothelial cells in the urinary sediment of 12 patients with bladder cancer. It was shown that the composition of the cell sample, and notably the proportion cells classified in the ATY II and POS (malignant) categories,... | 364,909 | [
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Identification of Proteus morganii and distinction from other Proteus species. | The identification of Proteus morganii in the clinical laboratory is complicated by the differences in incidence of hydrogen sulfide (H2S) production recorded by different sources. Since this quality appeared to be a frequent feature of strains of P. morganii at the author's center, all isolates of this species were st... | 364,977 | [
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Einstein's creative thinking and the general theory of relativity: a documented report. | A document written by Albert Einstein has recently come to light in which the eminent scientist described the actual sequence of his thoughts leading to the development of the general theory of relativity. The key creative thought was an instance of a type of creative cognition the author has previously designated "Jan... | 365,000 | [
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0.0252081... |
A controlled clinical trial of whole gut lavage as a method of bowel preparation for colonic operations. | In a prospective randomized clinical trial, whole gut lavage was evaluated against conventional mechanical cleansing for colonic operations. The lavage took less time to perform, was better tolerated by patients, and resulted in more satisfactory preparation as judged by frequency of collapsed intestines. There was no ... | 365,010 | [
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0.005170... |
The tensor fascia lata musculocutaneous flap. | The tensor fascia lata (TFL) muscle, together with the overlying skin of the anterolateral thigh, makes a reliable musculocutaneous unit. It can be lengthened safely by taking the fascia lata and the skin of the anterolateral mid and lower thigh to within 8 cm of the knee. The skin of the longer flap is supplied by lar... | 365,059 | [
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... |
Comparison between the early use of skin flap and skin graft for the correction of large tissue loss at the elbow. | Six patients with soft and hard tissue injuries of the elbow region during the 1973 Yom-Kippur war are discussed. These six patients were treated with two types of procedures. One group was initially treated with application of a split-thickness skin graft followed by a thoracoabdominal, abdominal, or chest skin flap. ... | 365,067 | [
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"Disappearing" spinal cord compression: oncolytic effect of glucocorticoids (and other chemotherapeutic agents) on epidural metastases. | Four patients suffering spinal cord compression resulting from epidural metastases were treated with adrenocorticosteroid hormones. For 2 patients, prompt relief of symptoms followed glucocorticoid therapy alone and was associated with marked shrinkage or disappearance of the metastasis, a direct oncolytic effect of th... | 365,073 | [
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Stereotactic radiofrequency hypophysectomy. | Clinical indications and technical details of RF hypophysectomy were reviewed. Evaluation of serveral hundred procedures toward pathologic and symptomatic amelioration ofmetastatic breast cancer and diabetic retinopathy, and also a few cases of intrasellar tumor, indicated sufficient benefit for endorsement in selected... | 365,098 | [
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Lactose variability of Escherichia coli in thermally stressed reactor effluent waters. | Lactose-utilizing and nalidixic acid-resistant populations of Escherichia coli, having an optimum growth temperature of 37 degrees C, were placed in modified diffusion chambers. The chambers were submerged in the epilimnion and hypolimnion of a 1,100-hectare lake (Par Pond) which receives cooling water from a nuclear p... | 365,111 | [
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Cell membrane ionic permeability, calcium ion, mitochondria, and carcinogenesis. | The interrelations between changes in cell membrane permeability, increase of intracellular concentration of calcium ion and alterations of the bioenergetic and genetic mechanisms of the mitochondria are formalized in a hypothesis of carcinogenesis. It seems very likely that changes in the permeability of the cell memb... | 365,128 | [
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Kidney glomerular pathology in various forms of acute and chronic hepatitis. | Kidney tissue from 99 unselected necropsy cases of various forms of hepatitis and liver cirrhosis was examined by histology and direct immunofluorescence. Glomerular deposits of hepatitis B surface antigen (HBsAg), IgG, IgM, and complement were found in nine of 59 cases (15%) of acute and subacute hepatitis and in seve... | 365,129 | [
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... |
[Ultrastructural analysis of rat pancreatic islet B-cells following thyroidectomy]. | Electron microscopic investigations have shown that after 5 days the pancreatic B-cells of thyroidectomized rats are characterized by marked endoplasmic reticulum dilatations, the reduction of Golgi complex, and the secretory granule extrusion into pericapillary spaces. Later (after 30 days), the insuline granule extru... | 365,135 | [
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[Chief types of placental trophism]. | An attempt is made to represent a theory on two types of placental throphism. The first type--nutrition is mainly performed at the expense of maternal proteins, which in the placental chorion undergo proteolysis with formation of polypeptides and amino acids; embryospecific proteins are formed in the liver of the embry... | 365,139 | [
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... |
Scleroderma: pathogenic factors and current management. | The aetiology of scleroderma remains unknown. Pathogenetic mechanisms may originate from vascular, collagen or immune abnormalities. These are reviewed and the current management although in the main unsatisfactory may alleviate a number of the distressing symptoms. | 365,159 | [
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Characterization of the guanosine 5'-triphosphate 3'-diphosphate and guanosine 5'-diphosphate 3'-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli. | Guanosine 5'-triphosphate 3'-diphosphate (pppGpp) and guanosine 5'-diphosphate 3'-diphosphate (ppGpp) are specifically degraded by a manganese-dependent pyrophosphorylase present in spoT+ but not in spoT- strains of Escherichia coli, indicating that the enzyme is the spoT gene product. The enzyme catalyzes the release ... | 365,225 | [
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Comparison of the actions of octopamine and catecholamines on single neurones of the rat cerebral cortex. | 1. The technique of microelectrophoresis was used to compare the actions of octopamine, noradrenaline and dopamine on single cortical neurones of the rat. 2. Octopamine both excited and depressed neurones of the cortex. Frequently cells depressed by noradrenaline were excited by octopamine; occasionally the converse wa... | 365,284 | [
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Physiotherapy and intermittent positive-pressure ventilation of chronic bronchitis. | Patients aged over 45 admitted to hospital with exacerbations of chronic bronchitis alone or in association with cor pulmonale, pneumonia, or respiratory failure were placed in one of three groups (men with hypoxia, men without hypoxia, and women). Patients within these groups were then randomly allocated to receive ei... | 365,289 | [
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Protection of the brain from hypoxia: a review. | A functional classification of hypoxia of the brain has been presented and some of its significant aspects have been discussed. Mechanisms of protection from hypoxia of the brain were reviewed under the headings of prevention, hyperventilation, hypothermia and protection by barbiturates. In prevention of hypoxia of the... | 365,304 | [
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0.1105565,... |
Osteosarcoma associated with Thorotrast administration: report of two cases and literature review. | Two cases of osteosarcoma are described arising in patients who had undergone angiography with Thorotrast during childhood. In both patients, there was radiographic and pathologic evidence of radioactive thorium dioxide deposition in bone as well as throughout the reticuloendothelial system. Thorotrast deposits were de... | 365,315 | [
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0.37... |
Final results of a multicenter placebo-controlled levamisole study of resectable lung cancer. | Two hundred and eleven patients with resectable lung cancer have been treated in a double-blind clinical investigation with either levamisole (50 mg three times a day) or a placebo given in 3-day courses starting 3 days before the operation and repeated every 2 weeks. The study was terminated after all patients had bee... | 365,323 | [
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Cold-induced insulin release in vitro: evidence for exocytosis. | Exposure of isolated pancreatic islets (mouse or rat) to low temperature (2 degrees C) evoked a threefold increase in insulin release irrespective of the glucose concentration in the incobation medium. Cold-induced release was transient and rewarming to 37 degrees C restored the sensitivity of B-cells to gluocose stimu... | 365,344 | [
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Identification by immunofluorescence of prolactin- and somatotropin-producing cells in the pituitary gland of the Mexican axolotl (Ambystoma mexicanum, Shaw). | The indirect immunofluorescence procedure was used to identify prolactin (LTH)-and somatotropin (STH)-producing cells in the pituitary of the Mexican axolotl. Histological staining techniques were employed to corroborate immunocytological results. The LTH cells are large, orange-staining cells (acidophils 1) distribute... | 365,348 | [
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The transposon Tn9 generates a 9 bp repeated sequence during integration. | We performed a genetic and sequencing analysis of insertions of the transposon Tn9 into the lac operon of E. coli. Genetic mapping of 70 insertions into lacl and Z shows that starting from the same point on the chromosome, Tn9 goes to at least 50 different points in these two genes. Although there are preferred regions... | 365,355 | [
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0.04266673,
-0.7382261,
-0.06788008,
-0.2500951,
-0.00700188,
0.01133816,
-0.1776911,
0.422518,
0.1915868,
-0.04... |
Practical use of swan-type double-bending gastrofiberscope. | After devising remote-controlled angle to gastrofiberscope in 1964, the authors invented a swan-type double-bending gastrofiberscope in 1967. The double-bending gastrofiberscope does not require any change in a patient's position, for the motion of the tip is sufficient to observe every part of the stomach on supine po... | 365,383 | [
-0.1629729,
0.130783,
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0.3502963,
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-0.1415275,
-0.3133044,
0.06875567,
0.06638706,
-0.43527... |
Interstitial immunofluorescence in nephritis of Sjögren's syndrome. | A patient with Sjögren's syndrome (SS) developed mild renal insufficiency without significant proteinuria; the diagnosis of interstitial nephritis secondary to SS was made on the basis of history, serological data and renal biopsy. The renal biopsy revealed immunofluorescence of the interstital infiltrates and the impo... | 365,406 | [
0.1439934,
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0.2308959,
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0.2679475,
0.04885213,
0.2557091,
0.004907233... |
Fracture separation of the coracoid process associated with acromioclavicular dislocation: conservative treatment--a case report and review of the literature. | Complete acromioclavicular dislocation associated with fracture separation of the base of the coracoid process is uncommon. This is a report of a 51-year-old man with severe emphysema and limited physical demands in whom the acromioclavicular dislocation and coracoid process fracture were treated conservatively with sl... | 365,413 | [
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0.3475367,
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... |
Gram negative bone and joint infection: sixty patients treated with amikacin. | Sixty patients with bone and joint infections secondary to gram negative infection were evaluated in relation to treatment with amikacin. Forty-seven of these patients had osteomyelitis, and 13 had joint infections, including 3 prosthetic replacements. The patients' average was 35 years and there was no predilection fo... | 365,414 | [
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0.08190622,
0.3510281,
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0.342851,
0... |
[Animal experimental studies on the regeneration of controlled bone lesions in varying cooling preceedures]. | Various controlled defects were inflicted under cooled conditions in the femur and humerus of sheep. Radiologic, histologic, and fluorescence microscopic examinations showed that an internally cooled fraise was advantageous. The positive effects, particularly in deeper areas of bone, were determined via quantitative an... | 365,518 | [
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0.2411819,
0.2795468,
0.04531348,
0.1430324,
-... |
Once daily propranolol in the treatment of mild to moderate hypertension: a dose range finding study. | Propranolol was administered in a single dose of 80 mg, 120 mg, 160 mg, 240 mg, or 320 mg, to 23 patients with essential mild to moderate hypertension in a randomised, double-blind cross-over study. All treatments produced a significant fall in lying and standing blood pressures compared with placebo, but there was no ... | 365,536 | [
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0.3006648,
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0.2939475,
0.08616798,
... |
Induction of deoxyribonucleic acid degradation in Escherichia coli by ozone. | Cell survival and deoxyribonucleic acid (DNA) degradation wave measured for wild-type Escherichia coli B251 cells after exposure to different concentrations of ozone. The results show that extensive breakdown of DNA occurs after ozonation and that the extent of ozone-induced DNA degradation generally correlates with th... | 365,568 | [
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0.1629252,
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0.04358308,
0.170933,
0.1371486,
0.4469638,
0.3634171,
-0.1520483,
... |
I-bar: myth and countermyth. | An attempt has been made to stress the importance of removable partial denture design totality and to clarify the relationship of other major components to I-bar retainer usage. As outlined in this article, I-bar retainer usage is only one part of a given, comprehensive design philosophy. Its successful use has been sh... | 365,634 | [
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0.2635526,
-0.1212522,
0.1432438,
0... |
Inhomogeneity of surface labelling of B-cells at prospective sites of exocytosis. | Using ferritin-labelled Ricinus communis agglutinin to detect lectin-binding sites of the pancreatic B-cell surface, we show that limited regions of the plasma membrane are deprived of lectin-binding sites over marginated secretory granules. Such deprived regions increased during glucose stimulation of B-cells in monol... | 365,658 | [
0.01769067,
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0.1454299,
-0.2148843,
0.309435,
0.1444931,
0.08592016,
... |
Factors affecting the transformation of Escherichia coli strain chi1776 by pBR322 plasmid DNA. | The susceptibility of E. coli strain chi1776 to transformation by pBR322 plasmid DNA was examined and optimized. Maximum transformation to tetracycline (Tc) resistance was achieved when cells were harvested from L broth at 5.0--6.0 . 10(7) cfu/ml, followed by washing twice in cold 0.1 M NaCl + 5 mM MgCl2 + 5 mM Tris, p... | 365,684 | [
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0.6067274,
0.1630576,
0.1070896,
-0.06127653,
... |
SstI: a restriction endonuclease from Streptomyces sp. stanford. | A strain of Streptomyces has been isolated which is a convenient source of a new restriction endonuclease. The enzyme has been prepared from extracts of these cells and its cleavage sites localized on phage lambda DNA. The enzyme, termed SstI, produces cohesive ends and should be useful for molecular cloning experiment... | 365,688 | [
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-0.4171843,
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0.2497338,
0.253091,
0.237207,
0.04256067,
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... |
The amino acid sequence of the ribosomal protein S8 of Escherichia coli. | The primary structure of protein S8 from the 30S subunit of Escherichia coli ribosomes has been determined by sequencing the peptides derived from tryptic, chymotryptic, thermolytic and staphylococcal protease digestion of the protein. Protein S8 has 129 amino acid residues which result in a molecular weight of 13996. ... | 365,698 | [
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-0.1205014,
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-0.03928702,
0.4193773,
0.167681,
-0.1272504,
... |
Using the Federal Register. | The Federal Register provides official notice of the issuance and contents of agency regulations and proposed rule changes and gives citizens an opportunity for input into their development. Knowing how to use this publication should be part of any administrator's repertory of skills. | 365,703 | [
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0.002944063,
0.3111341,
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0.1200146,
0.1411519,
-0.01199864,
-0.03436... |
Alterations in the tRNA's of Escherichia coli recovered from lethally infected animals. | Escherichia coli grown in chemically defined iron-deficient media or in fluids containing the iron-binding proteins transferrin, lactoferrin, or ovotransferrin have well-characterized alterations in the chromatographic properties of tRNA's containing the modified nucleoside 2-methylthio-N6-(delta2-isopentenyl)-adenosin... | 365,754 | [
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-0.4349205,
-0.1516527,
0.1673359,
0.2254906,
0.09267423,
-0.463... |
Genetics of Treponema: characterization of Treponema hyodysenteriae and its relationship to Treponema pallidum. | Saturation reassociation assays with 125I-labeled treponemal DNAs show that Treponema hyodysenteriae is genetically unrelated to T. pallidum (Nichols), T. phagedenis biotype Reiter, and T. refringens biotype Noguchi. Pathogenic and nonpathogenic isolates of T. hyodysenteriae exhibited 28% sequence homology and had an e... | 365,767 | [
0.1240971,
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0.3069765,
0.1682077,
-0.1815003,
... |
Dose-response study of a new oral bronchodilator, NAB 365 (clenbuterol). | A new oral bronchodilator, NAB 365 (clenbuterol), at doses of 10, 20, 30 and 40 microgram, was studied in a double-blind placebo-controlled incomplete cross-over study in 10 patients suffering from chronic bronchitis who had reversible airway obstruction. The ventilatory response was assessed by measurement of the forc... | 365,800 | [
0.3161051,
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0.04160665,
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0.2814461,
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0.3657638,
-0.03247486,... |
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