title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Evidence for predominant involvement of the B-cell system in the inflammatory process in Crohn's disease. | The cellular infiltrate in the walls of resected ileum and colon specimens obtained from patients with Crohn's disease was analysed. Mononuclear cells in tissue sections were characterized by the use of surface membrane markers and immuno-histochemical and enzyme histochemical techniques. It was found that: [1] B cells... | 370,970 | [
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Fatal veno-occlusive disease of the liver after chemotherapy, whole-body irradiation and bone marrow transplantation for refractory acute leukaemia. | Rapid onset of liver failure with fatal outcome occurred in a young woman after successful bone marrow transplantation undertaken for refractory acute leukaemia. Centrilobular necrosis was demonstrated at autopsy and was attributed to prior cytotoxic chemotherapy, possibly potentiated by the total-body irradiation that... | 371,033 | [
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A family with allo-immune neonatal neutropenia: group-specific pathogenicity of maternal antibodies. | A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in t... | 371,130 | [
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On the problems of efficacy of separation of IgM and IgG by different methods. | Using ultracentrifugation, gel filtration, and ion exchange, an attempt was made to completely separate immunoglobulin IgM and IgG present in pooled human serum of blood group O. The quality of separation was studied by testing IgG fractions for the presence of IgM by a sensitive detection method. It is demonstrated by... | 371,131 | [
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[Contrast density and side effect rate in lumbar myelography--a clinical comparison of Meglumin-Iocarmate and Metrizamide]. | The author reports that side effects were somewhat more frequent after metrizamide than after meglumin-iocarmate, in the course of a comparative study carried out at the reporting hospital from the beginning of 1977, using the water-soluble x-ray contrast media Amipaque (metrizamide) and Dimer X (meglumin-iocarmate). | 371,174 | [
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[Morphological characteristics of Nocardia asteroides]. | Morphology--by growth phases-- was studied in the N. asteroides strain isolated from cows suffering from mastitis in Cuba. During the growth N. asteroides culture underwent a number of morphological cyclic changes; definite morphology was typical for each growth phase. There was a similarity between the structure of th... | 371,289 | [
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Repair of bone defects by bone inductive material. | Experimental fibular defects in 16 rats were filled with an acid decalcified homogenous bone matrix (bone inductive material). Autogenous bone grafts in corresponding defects in the other legs of the same rats served as controls. After 3 months, 11 of the 16 defects filled with bone inductive material healed with bony ... | 371,330 | [
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Insulin in portal, hepatic and peripheral venous blood after glucose, tolbutamide and glipizide stimulation. Indication of insulin release from peripheral tissues. | Insulin in portal, hepatic and/or peripheral venous blood was determined in 16 patients admitted to a surgical ward for various diseases. Portal venous blood was obtained via a catheter introduced into the portal vein either through the umbilical vein remnant or transhepatically. Four subjects were given a peroral load... | 371,340 | [
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A stroke unit in a medical department. Organization and the first 100 patients. | A non-intensive stroke unit of 10 beds has been started in the Medical Department, Serafimerlasarettet, Stockholm. The aim is to make diagnostic and therapeutic studies in unselected stroke patients. Patients with suspect cerebrovascular disease in the Casualty Department are admitted to the unit non-selectively and wi... | 371,341 | [
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Medical complications of drug abuse. | Because we do not fully understand the cause of drug abuse, we do not currently have specific therapy for the abuse phenomenon. It is likely that those patients who abuse drugs are not a homogeneous treatment group. The patients seen most frequently because of medical complications probably represent only a small perce... | 371,359 | [
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A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. | Oral trimethoprim/sulfamethoxazole (TMP/SMZ) therapy was investigated in the prophylaxis of infections in granulocytopenia. Hospitalized granulocytopenic patients were allocated at random to receive TMP/SMZ (group 1) or to a control group (group 2). The percentage of febrile granulocytopenic days was significantly redu... | 371,396 | [
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Potentiation of schistosome granuloma formation. By lentinan--a T-cell adjuvant. | Lentinan is a fungal polysaccharide which acts as a T-cell adjuvant. When this glucan was administered to thymus-intact mice by intraperitoneal injection, conspicuously enlarged lung granulomas formed in response to either Schistosoma mansoni or S japonicum eggs or to antigen-coated polyacrylamide beads. Liver granulom... | 371,408 | [
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Immunogenetic aspects of intracerebral skin transplantation in inbred rats. | This study was undertaken to evaluate the ability of intracerebral skin grafts transplanted across different genetic disparities in the major histocompatibility complex (RT1) to elicit an immune response in inbred rats, as determined by histologic examination and by the ability of the grafts to sensitize the recipients... | 371,412 | [
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Immunocytochemical localization of parathyroid hormone in bovine parathyroid glands and human parathyroid adenomas. | Light and electron microscopic localization of parathyroid hormone (PTH) in human and bovine parathyroid tissue has been achieved using an indirect peroxidase labeled antibody method. Granular deposition of the reaction product was found throughout the chief cell cytoplasm. There was no nuclear staining. At the ultrast... | 371,413 | [
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The use of linear nonequilibrium thermodynamics in the study of renal physiology. | Classical formulations for the analysis of membrane transport processes, which ignored possible interactions between flows of diverse permeant species, often led to inconsistencies in the evaluation of permeability coefficients. For water flow induced by an osmotic pressure difference this difficulty was resolved by St... | 371,416 | [
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The efficacy of drugs and psychotherapy in the treatment of acute depressive episodes. | The efficacy of tricyclic antidepressants and various psychotherapies, in comparison with one another or in combination, has not been fully established in randomized clinical trials. The authors present a randomized controlled trial comparing the combination of amitriptyline and short-term interpersonal psychotherapy, ... | 371,421 | [
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Alcoholic liver damage is provoked by 4-methylpyrazole, which prolongs the influence of ethanol but reduces acetaldehyde levels. | Rats chronically fed ethanol developed liver injury only if they also received low doses of the alcohol dehydrogenase inhibitor, 4-methylpyrazole, suggesting that the consistency of the influence of ethanol and its metabolism, rather than the level of acetaldehyde or the degree of the metabolic effects, contributes to ... | 371,455 | [
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The broken wire suture. | The body is a hostile environment for wire sutures. Although the problems of electrochemical corrosion, direct chemical attack on the suture, and inflammation produced in reaction to the suture have been largley eliminated by the use of austenitic stainless steel wires, failure of the wires may still occur due to mecha... | 371,474 | [
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Bacitracin production by whole cells immobilized in polyacrylamide gel. | Whole cells of Bacillus sp., bacitracin-producing bacteria, were immobilized in polyacrylamide gel prepared by using 5% total acrylamide (95% acrylamide monomer and 5% N, N'-methylenebis acrylamide). Bacitracin production by the immobilized whole cells was examined by using various fermentation media. In starch-bouillo... | 371,538 | [
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Chloroquine resistance in malaria: accessibility of drug receptors to mefloquine. | The process of mefloquine accumulation was studied in mouse erythrocytes infected with either Plasmodium berghei CS (chloroquine susceptible) or P. berghei CR (chloroquine resistant). In both cases, mefloquine was accumulated by a saturable process with an apparent dissociation constant of 2.5 x 10(-6) M and an apparen... | 371,544 | [
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Clinical and radiologic remission in reticulum cell sarcoma of the brain. | Two patients with cerebral reticulum cell sarcoma (CRCS) are reported in whom neurologic abnormalities and radiologic (computerized tomographic [CT] scan) evidence of tumor remitted. In one patient, remission followed craniectomy and corticosteroid therapy and lasted for eight months. In the other patient, at least fou... | 371,595 | [
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Prosthetic valve endocarditis resulting from Nocardia asteroides. | Nocardia asteroides was isolated from the prosthetic valve of a 64-year-old woman who had died of endocarditis after aortic valve replacement. Multiple blood cultures had all been negative. This organism is increasingly being recognised as a pathogen and is usually sensitive to sulphonamides. These should be tried in c... | 371,642 | [
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Ergometrine or oxytocin? Blood loss and side-effects at spontaneous vertex delivery. | Blood loss and the frequency of vomiting were assessed at 88 spontaneous vertex deliveries. An i.v. injection of oxytocin 10 u was as effective as ergometrine 0.5 mg in controlling bleeding from the uterus after delivery. The continuous infusion of a dilute solution of oxytocin in the first stage of labour was not foll... | 371,650 | [
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Papular acrodermatitis of childhood and other papulo-vesicular acro-located syndromes. | Papular acrodermatitis of childhood (PAC), first recognized in Milan and described by Gianotti in 1955, is an infectious disease of childhood, of low infectivity, fairly widespread, and characterized by: (1) Non-relapsing erythemato-papular dermatitis localized to the face and limbs, lasting about 3 weeks. (2) Paracort... | 371,656 | [
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Circulating reticulin autoantibodies of IgA class in dermatitis herpetiformis. | Circulating reticulin autoantibodies of IgA class and anti-nuclear antigen antibodies were found in a high frequency in dermatitis herpetiformis patients as compared with age- and sex-matched controls. | 371,658 | [
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Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions. | The cysteinyl-tRNA synthetase from Escherichia coli only very slowly activates serine, alanine, and alpha-aminobutyrate, the possible competitors of cysteine. The upper limits on the values of kcat/KM for the amino acid dependent ATP/pyrophosphate exchange reactions, relative to that of cysteine, are less than 10(-8), ... | 371,674 | [
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Electrolyte effects on the activity of mutant enzymes in vivo and in vitro. | All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro. | 371,678 | [
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Searching the MEDLARS file on NLM and BRS a comparative study. | A comparison of the MEDLARS data base as it is currently available from the National Library of Medicine and Bibliographic Retrieval Services (BRS), Inc., is presented in chart format, and some major capability differences between the two systems are highlighted. The information inlcuded justifies the dual availability... | 371,721 | [
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-0.3258776,
-0.04643625,
-0.0876108,
0.2133278,
-0.04192026,
-0.28... |
Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation. | 1. Plasma exudation and blood flow changes induced by intradermal injection of prostaglandins E2 (PGE2), I2 (PG12), D2 (PGD2) and F2 alpha (PGF2 alpha) were measured in rabbit dorsal skin by the use of [131I]-albumin and 133Xe. 2. Little plasma exudation was produced by any of the prostaglandins when injected alone. 3.... | 371,730 | [
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0.2028849,
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0.2218854,
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... |
The use of metronidazole in the preparation of the bowel for surgery. | A randomized trial was carried out in 120 patients undergoing colonic surgery mainly for carcinoma. Sixty-one patients received metronidazole and Thalazole and 59 received Thalazole alone. Sepsis occurred in 8 (13.1 per cent) of the 61 patients who received metronidazole, compared with 29 (49.2 per cent) of 59 patients... | 371,742 | [
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0.3942267,
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0.00574... |
A rose by any other name... on 'naming of neurones' by Rowe and Stone. | Rowe and Stone dispose of descriptive terminologies for retinal units as 'essentialist' and argue for a 'neutral' multifactorial system redefined from previous W, X. Y nomenclatures. It is argued here that descriptive terminology need not be either essentialist or undesirable and that the W, X, Y terminology is too con... | 371,750 | [
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0.2458165,
0.1749572,
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0.02... |
Recent advances in drug therapy for epilepsy. | Recent advances in drug therapy for epilepsy have contributed to the reduction in the proportion of persons whose epilepsy is uncontrolled. New knowledge of the pharmacokinetics of phenytoin has led to a better understanding of the drug's bioavailability and uses. Carbamazepine has recently been introduced for the trea... | 371,777 | [
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0.02884978,
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... |
Tube leukocyte adherence inhibition (LAI) assay in gastrointestinal (GIT) cancer. | Tumor-specific immunity to carcinoma of the colon, pancreas and stomach was assayed by tube LAI. Cancers of the colon, pancreas and stomach, were shown to possess organ-type specific neoantigens. In 115 patients with colon cancer, 100%, 75%, 61% with Dukes' A, B and C cancer were LAI positive, respectively. Even a micr... | 371,789 | [
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0.3040958,
0.3744971,
0.0678584,
0.002945796,
0.2... |
Phase II study of Leo 1031 (prednimustine) in advanced ovarian carcinoma. | Thirty-six patients with advanced ovarian carcinoma, 21 who had not responded to conventional surgery and irradiation therapy and 15 who had not responded to conventional surgery, irradiation therapy, and chemotherapy, were treated in a phase II study with Leo 1031. Objective responses were obtained in ten (28%) of the... | 371,798 | [
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0.1174681,
0.3829142,
-0.113045... |
Phytohemagglutinin (PHA) skin test. Characterization of immunological properties and clinical application. | Immunological properties of phytohemagglutinin (PHA) skin reaction were investigated by animal and clinical experiments. In the guinea pigs an intradermal dose of PHA-P produced erythema and induration with a maximal response at 24 hours after the injection. Histologically it was characterized by perivascular infiltrat... | 371,848 | [
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0.2222923,
... |
Concentration and separation of erythrocytes infected with Plasmodium falciparum by gradient centrifugation. | Concentration of infected erythrocytes was achieved in cell suspensions derived from long-term culture of Plasmodium falciparum growing asynchronously in human erythrocytes. This new procedure involves the slow centrifugation (at 33 g) of erythrocyte suspensions through 5% Ficoll solutions. Mature asexual erythrocytic ... | 371,850 | [
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0.3485132,
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0.1995043,
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... |
Changes in pituitary gonadotropins during the amenorrhoea-galactorrhoea syndrome due to sulpiride. | Sulpiride, a dopamine receptor blocker which raises prolactin, was given to six women with idiopathic amenorrhoea for 10 days and to eleven women with regular cycles for 3 to 6 months. The latter group developed galactorrhoea and amenorrhoea during treatment. Basal LH AND FSH concentrations showed no significant change... | 371,860 | [
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0.2899291,
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0... |
Further studies on the effects of dihydrotestosterone on gonadotrophin release induced by LH-RH in men. | In order to determine the effect of dihydrotestosterone on the feed-back mechanism of the hypothalamo-pituitary testis axis, seven men were subjected to LH-RH tests before and after treatment with dihydrotestosterone. Our results clearly show that DHT at least in pharmacological doses, inhibits directly basal LH-RH and... | 371,861 | [
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0.07538728,
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0.0967466,
0.3683234,
0.2039179,
0.1165734,
... |
Allergy in cystic fibrosis. | Forty-four patients with cystic fibrosis, sixty-seven parents, and thirty-nine controls were compared with regard to their immediate cutaneous hypersensitivity, total and specific serum IgE and serum IgG4 concentrations. The patients had increased prick test reactions and specific IgE to Aspergillus fumigatus. The deve... | 371,883 | [
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0.1879107,
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-... |
Measurement of anti-thyroid antibodies in dried blood spots. | The method for determination of anti-thyroid antibodies in extracts of dried whole blood on filter paper was described. Antibodies in dried blood were stable at room temperature for at least 1 month and were extracted well by overnight elution. This simple method requires only a minimal 30 microliter of venous blood an... | 371,886 | [
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0.2710329,
0.1047333,
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0.... |
Tooth loss, prosthetics and dental treatment habits in a group of Swedish men. | Dental history, dental status, the need for prosthetic treatment and dental treatment habits were studied in 389 men aged 21--54 years. The men were selected from a group undergoing military refresher training in the south of Sweden. One percent of the men were toothless. About 3% had full dentures in one or both jaws ... | 371,907 | [
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0.03398289,
0.121629,
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A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents. | Newer nonsteroidal antiinflammatory agents (NSAI's) such as ibuprofen, neproxen, fenoprofen, and tolmetin have broadened the therapeutic choice and increased the chances of providing optimum arthritis control, but require careful assessment of the possibilities for unwanted drug effects when long-term therapy is requir... | 371,938 | [
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0.3578254,
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0.07296392,
-0.184... |
Detection of thymosin 5 in calf and mouse thymus and in nude mouse dysgenetic thymus. | Thymosin 5 was traced in calf and mouse thymuses by fluorochrome-labelled rabbit anti-calf thymosin. The presence of thymosin 5 or its individual components was found 1. in groups of cortical epithelial cells in calf thymuses and in single cortical epithelial cells in mouse thymuses. 2. In some marginal (blastema) cell... | 371,994 | [
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0.2024661,
0.2789845,
0.1715077,
... |
Family formation and the life cycle. | Mathematical expressions are developed for certain life cycles when only the age-specific birth and death rates are known. The probability at birth that a woman will have a specified number of children and the expected length of time spent before the first birth, between the first and the last child, and between the la... | 371,997 | [
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0.5595298,
0.3890299,
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... |
[Cefazedone in infectious diseases in gynecology. Clinical tests on efficacy and tolerance]. | A clinical trial on efficacy and tolerance of Cefazedone, a new semisynthetic Cephalosporine-derivate, was carried out in a gynaecological clinic on 75 patients. In 38 of these cases, besides the gynaecological affection, urinary tract infections were determined microbiologically (E. coli, P. mirabilis, klebsiella or e... | 372,073 | [
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0.3958033,
0.109217,
0.1883044,
0.1013642,
-0.07... |
[Lipoid A, a factor in the pathogenesis of chronic pyelonephritis. Experimental and clinical studies of a lipoid A dependent pathological immune reaction]. | Lipid A injected into the temporarily occluded renal pelvis of adult dogs, persisted in the kidney tissue and induced an abacterial interstitial nephritis with positive anti-lipid A titers. This reaction was increased by a single dose of lipid A vaccine, reduced by four consecutive immunisations prior to the lipid A in... | 372,074 | [
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0.1754773,
0.2603726,
0.06227051,
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0.01... |
[Kidney transplantation in the treatment of hypertension]. | Renal autotransplantation seems to be of great value as a means of renal revascularization in hypertension of renovascular origin, especially in those cases in which the preceding angioplastic procedure have resulted in failure or in cases with peripheral or difficult stenoses of the renal artery. One case is reported ... | 372,139 | [
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0.3406576,
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... |
Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction. | The guanine insertion enzyme isolated from Escherichia coli (tRNA transglycosylase) catalyzed the incorporation of bases of Q (queuosine) precursors into E. coli undermodified tRNAAsn and tRNATyr. These bases of Q precursors were inserted in the first position of the anticodon of tRNASn and tRNATyr, replacing guanine o... | 372,186 | [
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0.01544897,
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... |
Sequence of the 16 S-23 s spacer region in two ribosomal RNA operons of Escherichia coli. | The transducing phages lambdadaroE and lambdadilv5, which carry the Escherichia coli ribosomal RNA operons rrnD and rrnX, respectively, have been mapped with the restriction endonucleases BamHI, EcoRI, HindIII, and Sma I. Using hybridization techniques, we have located the ribosomal RNA genes on these phage DNAs. The D... | 372,188 | [
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0.1558629,
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... |
Can a small blood vessel prosthesis be derived from heterologous foreign body reactive tissue? | This study investigated as a small diameter vascular replacement the tissue formed adjacent to an implanted cylindrical foreign body, heterologously transplanted. Grafts of 4 mm i.d. were grown in rabbits and transplanted to dogs as segmental carotid and femoral artery replacements. These maintained 50% patency after 3... | 372,194 | [
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0.07586795,
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0.2908214,
0.03289668,... |
Comparison of media and techniques for detection of group A streptococci in throat swab specimens. | Detection of group A streptococci in primary throat cultures was compared by using aerobic and anerobic incubation with selective nonselective media. Sheep blood agar plates incubated anaerobically detected 98% of the group A streptococci, whereas aerobically incubated blood agar plates which had been stabbed at the ti... | 372,227 | [
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0.06671622,
... |
A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue. | Using antisera raised against defatted human cream we have demonstrated a new antigen on the epithelial membrane. An indirect immunoperoxidase technique on routinely processed histological sections was used, and we describe results which show that this antigen has a widespread but highly selective distribution, being a... | 372,248 | [
-0.01486404,
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-0.03726539,
0.1734097,
0.1980226,
-0.2257023,... |
A formalin fixative for immunochemical and ultrastructural studies on gastrointestinal endocrine cells. | Using indirect immunofluorescence, indirect immunoperoxidase, and unlabelled antibody enzyme techniques, gastrin, pancreatic glucagon, insulin, and somatostatin were localised in sections of both wax- and resin-embedded tissues that had been fixed in a buffered formalin solution. Ultrastructural preservation of the res... | 372,249 | [
0.1882898,
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0.4171335,
0.1235589,
-0.07427467,
-0.3050002,
... |
Uveitis and cerebral reticulum-cell sarcoma (large-cell lymphoma). Case report. | A patient with a peculiarly refractoy uveitis and vitritis was later found to have an infiltrative mass lesion of the posterior portion of the corpus callosum. The histopathological diagnosis of reticulum-cell sarcoma (large-cell lymphoma) was made after study of vitreous tissue obtained by pars plana vitrectomy of the... | 372,501 | [
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0.2861273,
-0.02065186,
0.02... |
Idiopathic rapidly progressive glomerulonephritis with C3 nephritic factor and hypocomplementemia. | A 7-year-old boy with mild renal failure and signs and symptoms of acute poststreptococcal glomerulonephritis including severe hypocomplementemia had, by renal biopsy, numerous crescents but no deposits in the glomerular capillary loops. Instead, deposits identical in location and composition to those described for chi... | 372,512 | [
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0.2207181,
0.02129835,
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0.1712957,
0.03960602,
-0.08071077,
-0.166632... |
The variable response of bacteria to excess ferric iron in host tissues. | The enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. Systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. Systemic iron, by an apparently anti-inflammatory action, d... | 372,534 | [
-0.1510159,
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0.02098437,
0.2650669,
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0.02413458,
-0.1964572,
0.2027589,
0.07625122,
0.1186978,
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-0.4797339,
-0.3855533,
0.1427927,
0.2177729,
0.2861034,
0.1156952,
0.5120102,
0.006384566,
-0.... |
Chromosomal location of the attachment site for the PA-2 prophage in Escherichia coli K-12. | The chromosomal attachment site for the PA-2 prophage is located between dsd and aroC at the approximately 50 min on the Escherichia coli K-12 genetic map. The attachment site is designated attPA-2. | 372,562 | [
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0.5161915,
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Respiratory failure in cancer patients. | A review of 180 cancer patients requiring mechanical ventilation disclosed that 26% survived to extubation, and 13% and 7% were alive at two and six months, respectively. Mortality was related to several factors individually and the cumulative number of organ systems dysfunctioning in a given patient. Compared with gen... | 372,604 | [
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Initial National Cancer Institute studies on mutagenesis as a prescreen for chemical carcinogens: an appraisal. | The efficacy of several in vitro and in vivo assays to detect carcinogens from a list of compounds was evaluated. Salmonella and polymerase A-deficient Escherichia coli in vitro were the most effective systems studied. Together they detected 82% of the organic carcinogens tested. Potential prescreening systems, which w... | 372,660 | [
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Introduction of an active enzyme into permeable cells of Escherichia coli: acquisition of ultraviolet light resistance by uvr mutants on introduction of T4 endonuclease V. | Plasmolysed cells of Escherichia coli N212 (uvr A recA) acquired ultraviolet resistance when the cells were exposed to high concentrations of T4 endonuclease V. With increasing concentrations of T4 enzyme, survivals of plasmolysed cells after ultraviolet irradiation increased while colony-forming ability of unirradiate... | 372,739 | [
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Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system. | The current status of the L5178Y/TK+/- leads to TK-/- mouse-lymphoma mutagenicity assay is described. Dose-survival-mutagenic response data are shown for 43 chemicals. Mutagenicity and cytotoxicity in the presence or absence of non-induced and/or Aroclor-induced rat-liver S-9 are compared for most of these chemicals, 2... | 372,791 | [
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0.006513955,
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Photodynamic effects of dyes on bacteria. III. Mutagenesis by acridine orange and 500-nm monochromatic light in strains of Escherichia coli that differ in repair capability. | In the presence of acridine orange (AO) and monochromatic 500-nm light, the recombination-deficient strain of Escherichia coli, WP10 (recA), showed a 15-fold increase in mutation rate over the wild-type (WP2) strain. Under the same conditions, strain Bs--1 (uvrB lexA lon) showed a 5-fold increase in mutation rate over ... | 372,792 | [
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The identification of soluble adult antigen on the tegumental surface of juvenile Fasciola hepatica. | An antiserum was raised in rabbits against a soluble extract of fresh homogenized adult Fasciola hepatica of rat origin and was then absorbed with rat and mouse tissue antigens. This antiserum reacted specifically with the surface coat of adult flukes, of both rat and mouse origin, by indirect immunofluorescence to sho... | 372,892 | [
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0.3314053,
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A fiberoptic reflection densitometer with cardiac output calculator. | A catheter-tip densitometer for indocyanine green is described consisting of a cardiac catheter containing optical fibers, an incandescent light source, a light detection unit and a processing unit. Half of the optical fibers guide the light to the blood at the tip of the catheter, the other half the back-scattered (re... | 372,921 | [
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0.1120556,
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A method for subtraction of the extrarenal "background" in dynamic 131I-hippurate renoscintigraphy. | Using a Toshiba GC-401 gamma camera with MDS computer Trinary a new method was developed for subtracting the extrarenal (extracanalicular) "background" from the count rate recorded over the kidneys after intravenous administration of 131I-hippurate. Mean subtraction factors of the "blood" activity curve were calculated... | 372,922 | [
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[Experiences with a new hypouricemic diuretic (tienilic acid): comparison with hydrochlorothiazide]. | A new hypouricemic diuretic (tienilic acid) was compared with hydrochlorothiazide in a double-blind study in 8 patients with mild essential hypertension. After a two-week placebo period the patients received either 250 mg tienilic acid or 50 mg hydrochlorothiazide in a single daily dose for 3 weeks. After a second plac... | 373,100 | [
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Surgical correction of longitudinal median or paramedian incisional hernia. | A new surgical technique for the correction of longitudinal median and paramedian incisional hernia uses the hernial sac itself, a tissue of good resistance and healing properties, to cover raw areas, remake the abdominal wall anatomy, propitiate tensionless sutures and render unnecessary the use of prosthetic material... | 373,143 | [
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0.0147... |
Aphakic glaucoma. | The cause of aphakic glaucoma should always be determined because treatment must be directed towards the aetiological mechanism. We have defined early aphakic glaucoma as that occurring within the first 6 postoperative weeks and late aphakic glaucoma as occurring at any later time. Of the various causes of glaucoma in ... | 373,170 | [
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[Antitumor action of preparation No. 31 in malignant tumors of the ovaries (a clinical cytological study)]. | The authors have analysed clinico-cytological findings to estimate the efficacy of the preparation No 31 therapy in 18 primary patients with ascites forms of malignant epithelial tumors of the ovary. This preparation was found to be a highly effective chemotherapeutic agent possessing a marked cytolytic effect on tumor... | 373,239 | [
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... |
Fibrinogen or its derivatives in the Kurloff cells. | We have investigated the occurrence of fibrinogen or its derivatives in the Kurloff bodies of female guinea pigs by means of immunofluorescence, histochemistry and ultrastructural analysis. The Kurloff bodies are fluorescent after incubation with anti-guinea pig fibrinogen immuno-globulins coupled with fluorescein isot... | 373,282 | [
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0.0141168... |
[Detection of receptors for the IgG Fc fragment as well as for the C3 component of complement in the spleen T-lymphocytes of CBA mice]. | The presence of receptors to the Fc fragment of IgG and to the C3 component in the complement of T lymphocytes in the spleen of CBA mice was studied. The study was made by the method based on Coons's indirect immunofluorescence test with the use of antithymocytic globulin, in combination with EA and EAC rossette-format... | 373,339 | [
0.3153659,
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Isolation of ribosomes from Escherichia coli by chromatography on methyl-albumin-kieselgel. | The present communication shows that ribosomes isolated by differential centrifugation retain their composition and biological activity during subsequent methyl-albumin-kieselgel (MAK)-chromatography. The data obtained were used to develop a novel chromatographic procedure for the isolation of ribosomes from E. coli ly... | 373,347 | [
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... |
Treatment of chronic osteomyelitis by free grafts of cancellous autologous bone tissue. A preliminary report. | Chronic osteomyelitis was treated by free grafts of autologous bone tissue in 13 consecutive patients aged 18 to 81 to years. In all patients the osteomyelitis was located in the leg, and Staphylococcus aureus was the causative organism. Seven had an infected non-union. The duration of the osteomyelitis varied from les... | 373,367 | [
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0.1641422,
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Diagnosis of Salmonella bacteria: antibodies against synthetic Salmonella O-antigen 8 for immunofluorescence and co-agglutination using sensitized protein A-containing staphylococci. | An antiserum against the synthetic disaccharide abequose 1 leads to 3 alpha rhamnose (AR), representative of Salmonella O-antigen 8, coupled to bovine serum albumin (BSA) was used for diagnosis of Salmonella bacteria by indirect immunofluorescence (IFL) and by co-agglutination (COA) using sensitized protein A-containin... | 373,381 | [
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0... |
Clinical comparison of dipivalyl epinephrine and epinephrine in the treatment of glaucoma. | Dipivalyl epinephrine, 0.1%, though slightly less effective in decreasing intraocular pressure, showed significantly fewer side effects than epinephrine hydrochloride, 2%. Seventeen patients with symmetrically increased intraocular pressures who completed a six-month double-masked crossover study showed a significant d... | 373,450 | [
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0.000613... |
The visual status of diabetic patients after renal transplantation. | To determine the effect of renal transplantation on visual status, we studied 134 eyes of 67 diabetic patients prospectively for one to seven years, with a mean of three years, after surgery. The best-corrected visual acuity and retinopathy status were determined at the time of surgery and annually thereafter. Useful v... | 373,454 | [
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0.02381226,
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0.6304823,
0.068751... |
Stridor in pediatric patients. | We have presented a classification scheme to help in evaluating the diagnosis of stridor in the pediatric patient. The correct diagnosis can usually be arrived at on the basis of a careful and complete history, physical examination, appropriate radiographic studies and bronchoscopy. The anesthesiologist should be aware... | 373,502 | [
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0.08786044,
0.08684903,
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0.2126737,
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-0.094247... |
Pathologic findings in guinea pigs inoculated intraperitoneally with the Legionnaires' disease bacterium. | Tissues from guinea pigs inoculated intraperitoneally with the Legionnaires' disease (LD) bacterium were studied with light, immunofluorescent, and electron microscopy. The principal gross lesion was diffuse peritonitis of varying severity. Microscopically, the peritonitis of covered by a mixed inflammatory infiltrate ... | 373,550 | [
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0.08919521,
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0.3616769,
0.027921... |
Legionnaires' disease: one person's perspective. | Since July 1976 when an outbreak of severe, acute respiratory disease of unknown origin occurred among attendees at the 58th Annual Convention of the American Legion in Philadelphia, great progress has been made, including identification of the causative organism, Legionella pneumophila. Clinical features include not o... | 373,555 | [
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Limitations of the Moeller lysine and ornithine decarboxylase tests. | A total of 40 fecal and environmental isolates, including 26 Escherichia coli strains, 9 members of the genus Klebsiella, and 5 members of the genus Enterobacter, were tested by enzyme assay for their endogenous and induced levels of lysine decarboxylase and ornithine decarboxylase when grown in Moeller decarboxylase m... | 373,624 | [
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0.1947891,
0.1901977,
0.09572303,
0.4... |
Beaded fluorescence pattern of FTA-ABS test associated with malignancy. | A beaded pattern of immunofluorescence (IF) occasionally occurs in routine FTA-ABS testing. This phenomenon strongly correlates with false-positive reactions in patients with SLE. We report on this IF finding in association with carcinoma of the colon. | 373,636 | [
0.09543312,
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... |
Polymorphic pemphigoid. | We describe 20 patients with a chronic polymorphic eruption; they shared clinical, histopathological, and therapeutic features of both dermatitis herpetiformis and bullous pemphigoid (BP). In 14 of these 20 cases, direct and indirect immunofluorescence studies corresponded to BP. The remaining six patients showed IgA d... | 373,638 | [
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0.1393859,
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0.1856294,
0.1680944,
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... |
Neurological complications of anticoagulation therapy: a neurologist's review. | Anticoagulant-induced bleeding may involve the brain, spinal cord, or peripheral nerves. It may occur with either coumarin or heparin anticoagulants, in the absence of trauma, and while prothrombin times, clotting times, or partial thromboplastin times are in accepted therapeutic ranges. Bleeding involving the brain oc... | 373,657 | [
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0.04940944,
0.1154... |
Apparent cure of intracranial Nocardia asteroides infection by minocycline. | Currently preferred therapy for CNS Nocardia infection is high-dose sulfonamide coupled with surgical drainage. Neither of these could be used in our patient; this led to therapy with minocycline alone. Several months after completion of minocycline therapy, the patient apparently is cured. His favorable outcome probab... | 373,660 | [
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0.1087494,
0.2975885,
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0.2668943... |
[Plasma vasopressin in premature infants on mechanical ventilation]. | A systematic study has been undertaken to improve the understanding of water regulation in premature babies who are artificially ventilated. Thirty nine premature babies, 16 normal (Group N, GA 31.4 weeks, B/W 1622 g) and 23 with respiratory distress syndrome who were ventilated with or without continuous positive pres... | 373,663 | [
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0.2629901,
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0.2226159,
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Immune processes induced by dysentery bacilli in mice. | Studies on immune reactions induced by dysentery bacilli revealed that mice immunized orally or intravenously develop the specific general resistance against reinfection with the microorganisms. Antibodies circulating against bacilli were the indicators of humoral immune response and the activated T lymphocyte detected... | 373,684 | [
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0.06694756,
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0.2612826,
0.04196284,
-0... |
In vitro proliferation of hematopoietic stem cells circulating in blood of patients with kidney allografts. | The in vitro formation of lymphoid (L-CFU) and myeloid (GM-CFU) colonies derived from progenitor cells circulating in blood of patients bearing kidney allografts was studied upon a stimulation with PHA and Colony Stimulating Factor. In patients undergoing acute rejection a marked reduction of L-CFU and GM-CFU was found... | 373,694 | [
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0.1161014,
0.04140517,... |
The microscopic characterization of multinucleated giant cells formed on polymeric surfaces perfused with blood. | Multinucleated, foreign body giant cells were formed by the fusion of blood monocytes on polymeric membranes perfused with blood during extended extracorporeal circulation. In the current study, heparinized blood, flowing in an arteriovenous shunt in a sheep, perfused polycarbonate, polypropylene and silicone rubber me... | 373,721 | [
0.03332155,
0.380455,
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0.2530127,
0.1086265,
0.2234777,
0.2444973,
0.1670672,
-0.0... |
Occurrence of Escherichia coli in feces of psittacine birds. | The feces of 125 psittacine birds, representing 12 species, were cultured on selective media to determine the presence of Escherichia coli. Only 13.6% (17) of the birds yielded E. coli. | 373,742 | [
-0.1922621,
0.1240247,
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0.08829658,
0.2765887,
0.1932113,
0.021899... |
[The respirophonogram as a means of drug screening (author's transl)]. | Respirophonography is an objective method of measuring respiratory and adventicious sounds. Current techniques make a perfect, albeit somewhat tedious registering of these respiratory murmurs possible, which can then be analysed for frequency. In this paper the method is investigated for its applicability to drug scree... | 373,778 | [
0.08341184,
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0.205538,
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0.0573549,
0.4685529,
-0.09204262,
-0.0660723... |
Phenylalanyl-tRNA synthetase of Escherichia coli K 10. Multiple enzyme-aminoacyl-tRNA complexes as a consequence of substrate specificity. | The interaction between Phe-tRNA(Phe) or other acyl-tRNA derivatives thereof and phenylalanyl-tRNA synthetase of Escherichia coli K 10 has been investigated by nonequilibrium dialysis, by fluorescence titration in the presence of 2-p-toluidinylnaphthalene-6-sulfonate, by the kinetics of the aminoacylation of tRNA(Phe),... | 373,798 | [
0.03953807,
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0.0939446,
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0.399623,
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0.4120505,
0.2597484,
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... |
Study of the cytoplasmic and outer membranes of Escherichia coli by deuterium magnetic resonance. | The cytoplasmic and outer membranes of Escherichia coli were studied between 0 and 40 degrees C by deuterium magnetic resonance quadrupolar echo spectroscopy. The L51 strain of E. coli was used to incorporate perdeuterated palmitic acid into the membrane phospholipids. The cytoplasmic and outer membranes were separated... | 373,801 | [
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0.3908134,
0.2660816,
0.02... |
Urinary tract infections after renal transplantation: do they matter? | The effect of urinary tract infections on renal function was assessed in 86 patients with renal allografts that had functioned for more than one year. Follow-up periods ranged from one to 10 years. Recurrent or persistent urinary sepsis was quite common in these long-term survivors but had no observable effect on graft... | 373,842 | [
0.2356205,
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0.3943462,
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0.215698,
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0.03868547,
0.1526873,
0.2261297,
-0.04405059,
0.007... |
Clinical involvement of Aeromonas hydrophila. | Aeromonas hydrophila has for some time been regarded as an opportunistic pathogen in hosts with impaired local or general defence mechanisms. Infections in such individuals are generally severe. The organism is also being isolated with increasing frequency throughout the world from a variety of focal and systemic infec... | 373,876 | [
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0.2240276,
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0.1293626,
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0.01682374,
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0.07215049,
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0.2382516,
-0.129... |
The fluoropyrimidines: biochemical mechanisms and design of clinical trials. | Our understanding of the biochemical events of fluoropyrimidine-induced cytotoxicity remains incomplete. However, we have a good perception of the activation and degradation pathways of these agents. Additionally, from studies performed in vitro we are gaining a new appreciation of the interactions between methotrexate... | 373,913 | [
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0.009533493,
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0.0490057,
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0.5668266,
0.2941241,
0.2927438,
0.02081289,
... |
Enzyme immunoassay of estrogen-like substances in plasma, with polyethylene glycol as precipitant. | We devised an enzyme immunoassay for plasma estrogen-like substances in pregnancy, using estriol covalently linked to horseradish peroxidase. Free and bound steroid were separated by use of polyethylene glycol reagent. The assay satisfies the normal criteria of specificity and precision. Results obtained by radioimmuno... | 373,925 | [
0.1078007,
0.247779,
0.005043852,
0.07591256,
0.04158044,
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-0.3407154,
0.09142212,
0.1658527,
0.298267,
0.1388647,
0.183543,
0.06085412,
0.121283,
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0.04165975,
-0.3825656,
0.5053573,
0.2020606,
0.07224786,
0.364776,
-0.002494536,
-0.1973283,
-0.067... |
Terminating a trial -- the ethical problem. | A comparative clinical trial will often lead to the conclusion that one regimen is clearly better than another. Should the estimated difference in the regimens be large and precisely determined, continuation of the trial would constitute abuse of the participants. Some earlier proposals for ethical decision making on c... | 373,945 | [
-0.1621672,
0.4582261,
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0.2435312,
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0.09840673,
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0.1061842,
0.1626802,
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0.3952261,
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0.2535754,
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0.4692948,
0.1403012,
0.1425603,
0.1399453,
0.086... |
Quality assurance of clinical data: diagnostic standardization. | Diagnostic standardization requires substantial effort, including detailed specification of procedures in a written protocol and training of examiners in such procedures. Success is neither automatic nor assured. It is essential to monitor performance through replicate examinations and/or computation of examiner varian... | 373,959 | [
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0.07035239,
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0.1628879,
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0.03577724,
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0.02663714,
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0.1813865,
0.1776594,
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-0.2353199... |
Quality assurance of clinical data: internal monitoring: patient and study management at the clinic. | Adquate methods to assure the quality of data collected at the clinic need to be developed. A full understanding of the limitations of physicians as information processors and reasonable performance expectations for physicians during peak information periods will result in concentrated planning for patient visits and w... | 373,960 | [
-0.1874432,
0.1992721,
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0.05306382,
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0.4134895,
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Comparative trial of co-trimoxazole and tetracycline in the treatment of lower respiratory tract infection. | One hundred and twenty-six adult patients with acute lower respiratory infection were studied in a double-blind trial. One group was treated with co-trimoxazole (480 mg trimethoprim and 2400 mg sulphamethoxazole) per day and the other group with tetracycline 2 g per day. The results showed that co-trimoxazole was signi... | 373,988 | [
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0.04924097,
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0.1650945,
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0.1526562,
0.002138841,... |
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