title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Urinary excretion of arylsulfatases in malnourished/vitamin A deficient children. | Serum vitamin A (retinol) levels were generally low in all malnourished children (6-15 microgram/100 ml) compared with control children (50 microgram/100 ml). A significant increase in vitamin A after appropriate therapy was observed in all malnourished groups. Dietary supplements of proteins and calories even without ... | 38,922 | [
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Drugs for inhibition of premature labor. | Effective inhibition of premature labor depends on prompt initiation of treatment. The author discusses factors initiating parturition, and the benefits and risks for mother and child of administration of alcohol, beta adrenergic agents, magnesium sulfate, and other agents that may counteract them. | 38,929 | [
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Catabolic effects of adrenaline and angiotensin II in the perfused liver of normal and genetically obese (ob/ob) mice. | 1. Rapid effects of hormones on the metabolism of glycogen and fatty acids were studied in the perfused liver of normal and genetically obese (ob/ob) mice. 2. In livers from normal and obese mice adrenaline and angiotensin II stimulated glycogenolysis. 3. These hormones inhibited the synthesis de novo of long-chain fat... | 38,934 | [
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The treatment of glaucoma: role of beta-blocking agents. | The sudden development of a red painful eye with blurred vision may be an acute attack of angle closure glaucoma which requires emergency attention. Once the attack is controlled with medication, surgical intervention with a peripheral iridectomy is indicated to relieve relative pupillary block. Eyes subject to angle c... | 38,956 | [
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Effects of 4 beta-adrenoceptor blocking drugs on blood pressure and exercise heart rate in hypertension. | The effects of 4 beta-adrenoceptor blocking drugs on blood pressure and on exercise tachycardia were compared in a within-patient study of patients with uncomplicated essential hypertension. Twelve patients were treated with propranolol, practolol and atenolol and 7 of the same patients also received oxprenolol. Each p... | 38,965 | [
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[Comparative characteristics of the effect of noninhalational narcotics on the reflex mechanisms of blood circulation regulation]. | It has been shown in experiments on cats with intact brain, as well as on decerebrated and spinal animals that chloralose, sombrevine and viadril exert no pronounced effect on initial electric activity in the renal nerve or baroreceptor inhibition of the neurogenous vascular tone, but inhibit vasomotor responses at sti... | 38,996 | [
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[Toxicity of lithium salts in combined use with neuroleptics]. | Experiments on white mice showed that in combined administration of LD16, LD50 or LD84 of aminazin, triphtazine or haloperidol with the same doses of lithium carbonate, chloride or hydroxybutyrate, the lethal dose exceeded the total lethal dose in the event the drugs were administered alone. Non-lethal doses of the lit... | 38,997 | [
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A double-blind comparison of prazepam with diazepam, chlorazepate dipotassium and placebo in anxious out-patients. | The study compared prazepam with diazepam, chlorazepate dipotassium, and placebo in the treatment of anxious out-patients. Patients were screened for participation in the study to be sure they met the criteria for inclusion. Patients were excluded if they had complicating physical or mental problems. All patients signe... | 39,012 | [
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Lactoperoxidase binding to streptococci. | There have been conflicting reports regarding the binding of lactoperoxidase to bacterial cell surfaces. We describe here the effects of cell-bound lactoperoxidase on acid production by suspensions of Streptococcus mutans (NCTC 10449) in the presence of hydrogen peroxide and thiocyanate. Saline suspensions of log-phase... | 39,032 | [
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Conformational stability of ribonuclease T1. I. Thermal denaturation and effects of salts. | The thermal transition of RNase T1 was studied by two different methods; tryptophan residue fluorescence and circular dichroism. The fluorescence measurements provide information about the environment of the indole group and CD measurements on the gross conformation of the polypeptide chain. Both measurements at pH 5 g... | 39,067 | [
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Improved procedure for transport of dental plaque samples and other clinical specimens containing anaerobic bacteria. | An improved transport system for samples containing anaerobic bacteria was developed. This system increased the recovery rate of anaerobic bacteria up to 28.8% as compared to a commonly used method. | 39,087 | [
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Kinetics and mechanism of chlorambucil hydrolysis. | The kinetics and mechanism of hydrolysis of the cytotoxic drug chlorambucil were investigated. A study of the reaction order and of the pH, dielectric constant, and ionic strength effects on the reaction rate revealed that the hydrolysis was a limiting unimolecular nucleophilic substitution, the rate-determining step b... | 39,159 | [
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Nucleoside phosphotransferase of chick embryo. | This paper describes a purification procedure and some properties of a nonspecific nucleoside phosphotransferase of chick embryo, an activity which catalyzes the transfer of chick embryo, an activity which catalyzes the transfer of the phosphate ester from a deoxyribonucleotide or a pyrimidine ribonucleotide to a deoxy... | 39,250 | [
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The effect of vanadate on human kidney potassium dependent phosphatase. | This study examined the effects of vanadate on the potassium dependent phosphatase activity present in purified human kidney microsomal (Na+ + K+)-adenosine triphosphatase. Vanadate anion inhibited the K+-dependent phosphatase at a K1 of 35 nM. This inhibition was noncompetitive with the substrate, p-nitrophenylphospha... | 39,261 | [
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Excitation-contraction coupling in frog sartorius and the role of the surface charge due to the carboxyl group of sialic acid. | Frog sartorius muscle fibres were incubated with the enzyme neuraminidase which is known to remove surface-bound sialic acids. The sialic acid content of the incubation media was analysed, and the relationship between the threshold of contraction and the altered pH and divalent cation concentration was investigated. Th... | 39,290 | [
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Induction by thymic fractions of T cell subsets capable of modulating GVHR intensity. | Two thymic stromal fractions previously shown to have specific enhancing effects on anatomically distinct T cell populations were tested for their capacity to induce functionally distinct T cell subsets. Parental mice were injected with either soluble thymic fraction (STF) or insoluble thymic fraction (ITF), and their ... | 39,373 | [
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Fructose-1,6-bisphosphate aldolase from Vibrio marinus, a psychrophilic marine bacterium. | Fructose-1,6-bisphosphate aldolase (Fru-P2A) from a psychrophilic marine bacterium was found to be Class II aldolase based on activation by K+, activation by divalent cations, inactivation by EDTA, low molecular weight, and similar values for Km, Vmax, and Arrhenius activation energy. This enzyme was not markedly diffe... | 39,385 | [
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Disseminated intravascular coagulation related to outcome in head injury. | In 46 head-injured patients coagulation studies were performed immediately after admission. In 76% of all cases signs of disseminated intravascular coagulation (DIC) were found. DIC was related to the severity of the injury and outcome. It is suggested that DIC may be used as an important parameter in assessing cranioc... | 39,428 | [
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Fentanyl concentrations in brain and serum during respiratory acid--base changes in the dog. | It is a clinical impression that less fentanyl is needed for anesthesia during hyperventilation and hypocarbia. If true, it might be due to both increased penetration of fentanyl, a highly lipid-soluble agent, into the brain and increased brain tissue binding. Serum and brain concentrations of fentanyl were determined ... | 39,475 | [
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Pneumonia and pneumococcal infections, with special reference to pneumococcal pneumonia. The 1979 J. Burns Amberson lecture. | An etiologic classification of acute pneumonia was presented and the relative importance of some of the causative agents was briefly reviewed. The early developments of the therapy of pneumococcal pneumonia with type-specific antisera, sulfonamide drugs, and antimicrobial drugs were reviewed, mostly from the experience... | 39,481 | [
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Effects of pH of the medium on flagellation of Vibrio parahaemolyticus. | Formation of the lateral flagella by Vibrio parahaemolyticus was inhibited under an alkaline condition of the medium. However, flagellation of the polar monotrichous flagellum was not affected in the same condition. Flagellation of the lateral flagella depended on the pH of the medium. | 39,500 | [
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[Noisy circulation syndrome. Study of 28 cases]. | Twenty eight subjects with noisy circulation sindrome (NCS) defined as cases at least, with 4 murmurs in different arteries were studied. They were divided in groups A, B, C formed by 9 normal children, 9 peripheral vascular atherosclerosis adults and 10 Takayasu's arteritis cases, respectively. In the whole population... | 39,522 | [
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Interactions of small molecules with phospholipid bilayers. Binding to egg phosphatidylcholine of some organic anions (bromosulphophthalein, oestrone sulphate, haem and bilirubin) that bind to ligandin and aminoazo-dye-binding protein A. | 1. To assess the possible involvement of ligandin and aminoazo-dye-binding protein A in intracellular transport it is necessary to know how their ligands, most of which are molecules with hydrophobic moieties, interact with cellular membranes. To obtain such information we examined the interactions of bromosulphophthal... | 39,548 | [
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The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. | 1. The effects of Ca2+ (mainly by using EGTA buffers), pH, ATP and ADP on the activity of the 2-oxoglutarate dehydrogenase complex from pig heart were explored. 2. Ca2+ (about 30 micrometer) resulted in a decrease in the apparent Km for 2-oxoglutarate from 2.1 to 0.16 mM (at pH 7) without altering the maximal velocity.... | 39,549 | [
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The assay and partial characterization of macromolecular heparin depolymerase activity in rat small intestine. | Homogenates of rat small intestine can depolymerize macromolecular rat skin heparin (RS heparin) to products similar in size to commercial heparin [Horner (1972) Proc. Natl. Acad. Sci. U.S.A. 69, 3469--3473]. This activity is attributed to an enzyme provisionally named 'macromolecular heparin depolymerase'. An assay fo... | 39,552 | [
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Partial purification and properties of L-asparagine synthetase from mouse pancreas. | l-Asparagine synthetase was partially purified from mouse pancreas to a final mean specific activity of 0.10 unit/mg of protein. The enzyme exhibited an l-glutaminase activity which was not affected by l-asparate, NH(4)Cl, ATP-MgCl(2), l-glutamate, AMP (sodium salt) or sodium pyrophosphate. The l-glutamine-dependent l-... | 39,555 | [
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Microbiological activity of cefazedone as compared to cefazolin and cephalothin. | In a comparison of the antibacterial activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) as compared to other cephalosporins it can be seen that cefazedone possesses g... | 39,575 | [
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[Synthesis of several phenoxymethylphenyl derivatives with local-anesthetic activity (author's transl)]. | 1. Several 4-phenoxymethyl-procaine derivatives (IV) were synthetised in order to investigate the influence of the intermediate chain on the activity. 2. By replacing the CH2-CH2-group in fomocain by a COO-group we succeeded in doubling the efficacy of this local anesthetic. 3. The type and position of the hetero atoms... | 39,578 | [
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[Synthesis and H2-antihistaminic activity of ring methylated metiamide analogues. 4th communication: H2-antihistaminic agents (author's transl)]. | In studies on structure-activity relationships of histamine H2-receptor antagonists, the influence of different imidazole ring methylation on the H2-antagonist activity was investigated. 2-Methyl-, 5-methyl-, 2,5-dimethyl- and unsubstituted analogues of metiamide were prepared and tested. While 5-methyl- and unmethylat... | 39,579 | [
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A comparative study of the effects of prostaglandins and H2-receptor antagonists on gastric acid secretion, mucosal blood flow and ulcer formation. | The prostaglandins E2 and 16,16-dimethyl-PGE2 methyl ester were compared with the H2-receptor antagonists burimamide and metiamide for their effects on gastric acid secretion (GAS) and gastric mucosal blood flow (MBF) in rats and dogs, and on ulcer formation in rats. Orally, both 16,16-dimethyl-PGE2 methyl ester (20 mi... | 39,581 | [
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Dermatitis as a side-effect of long-term topical treatment with certain beta-blocking agents. | Three groups of glaucoma patients, treated topically with various beta-blocking agents, were studied for mucocutaneous side-effects of long-term therapy. In five of eleven patients with ocular and/or periocular dermatitis as an adverse reaction to long-term treatment with metoprolol eye drops a dermatitis, reproducible... | 39,586 | [
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Differential effects of pH and inositol hexaphosphate on the spectroscopic properties of the alpha and beta subunits in methemoglobins M Milwaukee and A. | The effect of pH and inositol hexaphosphate on the electron spin resonance spectra of the alpha-hemes (g = 6.0) and the beta-hemes (g = 6.7) has been measured in methemoglobin M Milwaukee and compared with that of methemoglobin A (g = 6.0). The beta-hemes are found to be comparatively insensitive to both effectors whil... | 39,622 | [
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The relationship between pH and the amount of calcium bound to glycerinated muscle fibers. | Variation of pH over the range 6.2--7.4 had no effect on the Ca2+ titration curve of glycerinated rabbit psoas muscle fibers. Thus the effect of H+ on muscle contraction is not due to a simple H+-Ca2+ competition for binding sites. | 39,630 | [
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[Allosteric regulation in the open futile cycle fructose-6-P--fructose-1,6-P2]. | The effect of fructosebisphosphatase inhibition and phosphofructokinase activation by fructose-1,6-bisphosphate on a parasite recirculation of substrates in the futile (energy-dissipating) cycle fructose-6-P in equilibrium fructose-1,6-P2 has been studied. Both the inhibition and activation have been shown to produce s... | 39,635 | [
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Phosphoester specificity of purified human liver alkaline phosphatase. | Kinetic parameters for the hydrolysis of a number of physiologically important phosphoesters by purified human liver alkaline phosphatase have been determined. The enzyme was studied at pH values of 7.0 to 10.0. The affinity of the enzyme for the compounds was determined by competition experiments and by their direct e... | 39,670 | [
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The stoichiometry and stability of the NADP complexes with manganese(II) ions as studied by electron paramagnetic resonance. | Magnetic resonance techniques have been applied to study the stability of the complexes formed between Mn(II) ions and NADP in aqueous solutions at a pH of 7.5 and 20 degrees C. The electron paramagnetic resonance (epr) data indicate that at low Mn(II) ion concentrations ([Mn(II)] less than 1 mM; [NADP] approximately 5... | 39,671 | [
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The effects of temperature, local anaesthetics, pH, divalent cations, and group-specific reagents on repriming and repolarization-induced contractures in frog skeletal muscle. | Contractures appear during repolarization of frog toe muscles in media containing perchlorate in place of chloride. These contractures were suppressed or delayed by certain procedures which retard the repriming of K contractures, i.e., by sufficient reduction in temperature or by alkaline pH in solutions lacking divale... | 39,672 | [
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Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one]. | The cardiotonic activity of a new, noncatechol, nonglycoside agent, amrinone, was investigated in vitro and in anesthestized and unanesthetized dogs. Amrinone (3-100 microgram/ml) caused a dose-dependent increase in papillary muscle developed tension and df/dt without significant changes in duration of the contractile ... | 39,684 | [
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Primary amniotic fluid cell, skin fibroblast and liver alpha-L-fucosidase and its relation to cystic fibrosis. | Cultured skin fibroblast and primary amniotic fluid cell alpha-L-fucosidase had a double optimum of pH 5.0 and 6.0. Alpha-L-fucosidase was largely bound as a single peak to DEAE-cellulose at pH 6.6. Sucrose density isoelectric focusing revealed up to seven components with pI values of 4.9, 5.2, 5.4, 5.8, 6.1, 6.5 and 7... | 39,687 | [
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Plasma gamma-glutamyl transpeptidase in heroin addicts. | Plasma gamma-glutamyl transpeptidase was measured in 25 heroin addicts. The purpose was to find out if the long term administration of heroin would lead to a stimulation of GGTP due to the detoxication of this drug in the endoplasmatic reticulum of the liver. In 10 patients the elevation of GGTP could be attributed to ... | 39,692 | [
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Interaction of alpha- and beta-adrenergic receptor blocking agents: circulatory effects in the conscious rat. | The alpha-receptor blockers phenoxybenzamine and phentolamine produced similar circulatory effects, e.g. hypotension and tachycardia in the conscious rat. The hypotension was more pronounced than that seen after an acute cervical transection of the spinal cord or after hexamethonium treatment. The tachycardia was block... | 39,712 | [
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Biotransformation of azapetine to oxazapetine in rat and rabbit liver fractions. | The biotransformation of azapetine (I) to a lactam metabolite, oxazapetine (II), has been investigated in rat and rabbit hepatic subcellular fractions. In the presence of NADPH, II was produced from I in incubation mixtures containing 9000 g supernatant fraction or combined microsomes and cytosol, but not in mixtures c... | 39,720 | [
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[Neuropharmacological data on the striatum]. | The striatum constitutes the most voluminous basal ganglia in man. It is issued from ganglionic eminences which are very early bound by limbic kernels. If the cortical and reticulo-spinal projections have been first described the existence of anatomical connexions with the limbic system offers a large number of functio... | 39,737 | [
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Intrauterine devices: medicated and nonmedicated. | The main benefits of intrauterine devices (IUDs) are a lack of adverse systemic effects, excellent effectiveness, high continuation rates and the single act of motivation required for use. First year failure rates range from 2% to 3%, but decline steadily thereafter to a cumulative annual failure rate of less than 1% a... | 39,813 | [
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Teenagers and contraception. | Early sexual activity in young women has created new problems in contraception and gynecologic pathology for physicians. None of the existing birth control methods seems ideally adapted to the young: oran contraceptives, the only infallible method, may present adverse effects. Intrauterine devices may result in expulsi... | 39,828 | [
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Aerobic and anaerobic cervical flora of healthy Thai women. | The bacteriologic study of the cervical flora in 50 healthy women revealed that 70% harbored mixed aerobic and anaerobic organisms. Aerobic organisms alone were recovered in 15 women (30%). Polymicrobial organisms were found in all but five women (in these only one aerobe was isolated per patient). The majority of pati... | 39,833 | [
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Rheumatic heart disease diagnosed during pregnancy: a 30-year follow-up. | One hundred one patients originally diagnosed as having rheumatic heart disease (RHD) during the years 1945-1948 were reevaluated in 1975 to determine the natural history of the disease. Twenty patients (19.8%) showed no sign of RHD. Of the patients with confirmed RHD, 56 (70.0%) had their original lesion confirmed, wh... | 39,838 | [
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Euhypnos Forte (temazepam) in insomniac patients: a clinical trial in general practice. | In an open evaluation, soft gelatin capsules containing 20 mg temazepam (Euhypnos Forte) were administrated in doses of 40--60 mg to 134 patients from twenty-two general practices. The patients selected by the general practitioners werethose known to require hypnotics but in whom conventional doses had proven unsatisfa... | 39,856 | [
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[Risk of incompatibility reactions in the repeated use of contrast media in urography]. | In a prospective study 260 urographies were evaluated regarding clinical compatibility. In altogether 11% of the patients mild incompatibility reactions were observed (heat sensation, urticaria, nausea, vomiting). 29% of the patients with known prior contrast agent incompatibility suffered from anaphylactoid symptoms m... | 39,885 | [
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Production of heat-stable, methanol-soluble enterotoxin by Yersinia enterocolitica. | Seven isolates of Yersinia enterocolitica serotype 0:8, recovered during an outbreak of gastrointestinal illness, were examined for enterotoxin production. All seven strains were enterotoxigenic in the suckling mouse model, and three of five isolates tested produced keratoconjunctivitis in the guinea pig eye model (Ser... | 39,891 | [
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Evidence for pili-mediated adherence of Klebsiella pneumoniae to rat bladder epithelial cells in vitro. | The possible role of pili in the pathogenesis of urinary tract infections caused by Klebsiella pneumoniae was studied in an in vitro mixture of a phosphate-buffered saline suspension of rat bladder epithelial cells and phosphate-buffered saline-washed K. pneumoniae. Nonpiliated and piliated populations derived from a s... | 39,895 | [
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Murine lymphoma alkaline phosphatase: a cell membrane carcinofetal enzyme. | Alkaline phosphatase (APase) has been shown to have a membrane-bound localization in the murine fetal thymus, in murine thymic lymphoma and in adult spleen. Since it was suggested from these previous experiments that the lymphoma APase might represent an embryonic function, a detailed biochemical comparison of the lymp... | 39,898 | [
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Variable pH dependence of the myosin-ATPase in different muscles of the rat. | For the histochemical demosntration of the Myosin-ATPase (EC 3.6.1.3) the pH of both the preincubation and the incubation medium was varied in steps of 1 within a range: 10.2 to 10.5 and 9.3 to 9.9, respectively. The optimum combinations of both pH values, defined as the ones providing most consistent contrast among th... | 39,907 | [
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... |
Enzyme-linked immunosorbent assay for detection of Streptococcus pneumoniae antigen. | An enzyme-linked immunosorbent assay (ELISA) was developed for the detection of Streptococcus pneumoniae polysaccharide antigen in cerebrospinal fluid and serum. Sensitivity and specificity were determined for purified antigen preparations. Specificity was also evaluated in the rabbit meningitis model, and the sensitiv... | 39,946 | [
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Inheritance of lysozyme deficiency in rabbits. | The phenotypes of 273 offspring of 56 matings of various genotypes of lysozyme-deficient and normal New Zealand white rabbits were analyzed. It was determined that lysozyme deficiency of rabbits is inherited as an autosomal recessive with complete penetrance. The symbol ld is suggested for the gene for lysozyme deficie... | 39,955 | [
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On the possible mode of action of serotonin in neurotransmission and brain dysfunction. | Criteria necessary to classify a substance as neurotransmitter are used to determine whether disturbances in neurotransmitter function are involved in brain disorders. Six rather stringent criteria for a neurotransmitter are satisfied by the biogenic amine 5-hydroxytryptamine (5-HT): 1. the availability of 5-HT within ... | 39,972 | [
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Tripeptide analogues of melanocyte-stimulating hormone release-inhibiting hormone (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor. | Fourteen di- and tripeptide analogues of MIF, Pro-Leu-Gly-NH2, have been synthesized and assayed for inhibition of oxotremorine-induced tremor. Replacement of Pro by HCO-Pro or cyclopentanecarboxylic acid gave inactive analogues, while some peptides of the general structure less than Glu-Leu-Gly-NR1R2 were highly activ... | 40,028 | [
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On two-dimensional passive random walk in lipid bilayers and fluid pathways in biomembranes. | The lateral mobility of pyrene, pyrene decanoic acid, and 1-palmitoyl-2-pyrene decanoyl-phosphatidyl choline (pyrene lecithin) in lipid bilayers is determined by the excimer formation technique. This method is applied to vesicles of lecithins differing in chain length and in the degree of saturation of the hydrocarbon... | 40,032 | [
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0.03808076,
0.001797... |
Specificity and mode of cleavage of the pH 4.0 endonuclease from adenovirus type 2 - infected KB cells. | Adenovirus type 2 or lambda DNA was digested with the pH 4.0 endonuclease, purified from adenovirus 2-infected KB cells. The enzyme produces a limit digest of approximate size in the range of 140-210 base pairs long. The termini of the DNA fragments generated by the endonuclease digestion had 3'-P and 5'-OH groups. The... | 40,209 | [
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Oral complications of bone marrow transplantation in adults with acute leukemia. | In recent years bone marrow transplantation has become increasingly feasible for treating adult acute leukemia unresponsive to chemotherapy. However, the technique is not without significant intrinsic morbidity. The mouth is a singularly sensitive reflector of the cytotoxic, infectious, and hemorrhagic complications an... | 40,210 | [
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The laminar organization of optic nerve fibres in the tectum of goldfish. | Potentials in the tectum of large (12--20 cm) goldfish, evoked by stimulation of the optic nerve, were recorded extracellularly with double-barrelled electrodes (d.c., saline and a.c., Woods metal--Pt). Four fibre groups (E, M1, M2, M3) were recorded at latencies of approximately 2, 3, 5 and 8 ms after stimulation (con... | 40,252 | [
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The need for sublethal studies. | In problems of waste management, the preoccupation of the would-be manager is the means whereby waste may be released to the environment without impairing the health of the biota inhabiting the receiving waters. In such a situation, measurements based upon acute poisoning are unhelpful since they tell nothing of the im... | 40,270 | [
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Biological variables, especially skeletal deformities in fish, for monitoring marine pollution. | When considering principles for selection of indicators, i.e. biological variables, for monitoring marine pollution, it must be regarded as important to search for effects on the highest possible level of organization. For a global monitoring programme there are, however, many practical limitations in the number of use... | 40,272 | [
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Pollution-induced changes in populations. | The effects of pollution by organic matter, oil or industrial waste on marine communities are remarkably similar. Diversity values fall, biomass and numbers of organisms initially rise and then fall as the pollution load is increased. Diversity indices are, however, insensitive to pollution-induced changes and have to ... | 40,277 | [
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The osmotic fragility of red blood cells: a re-evaluation of technical conditions. | The osmotic fragility of red blood cells is influenced by even modest environmental changes. Consequently, the technical procedure must be strictly standardized. This implies that temperature equilibrium of the buffered salt solutions should be reached prior to the addition of blood. Furthermore, since erroneous statem... | 40,304 | [
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Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal ulcer patients. | The significance of antral pH for the basal serum level of immunoreactive gastrin and for the release of gastrin during insulin hypoglycemia has been studied in duodenal ulcer (DU) patients. To permit paired comparisons, 14 DU patients underwent two or three tests with insulin. Venous blood samples were collected at fi... | 40,312 | [
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[The effect of large burns in ruminants on the edibility of meat]. | The effect of non-contact burns was studied on a model of a slaughter ruminant. The study included the examination of the penetration of germs into the blood stream and into the meat and of the main changes characterizing the ripening of the obtained meat. The tests were conducted with two groups of animals, killed 1) ... | 40,336 | [
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Developments in understanding the physiology and pharmacology of parkinsonism. | While the era of major advances in understanding and treating parkinsonism seems to be over, steady progress is being made in elucidating physiological and pharmacological aspects of extrapyramidal function. The dramatic impact of levodopa therapy has been followed by the recognition of serious limitations to its long-... | 40,381 | [
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Uptake of putative neurotransmitters in the organ of Corti. | In vitro uptake of putative neurotransmitters into the organ of Corti of the guinea pig was studied by autoradiography. After incubation in 3H-glycine the label was heaviest over the inner hair cell, but was not confined to the synaptic region of the cell. After incubation in 3H-GABA, 3H-glutamate and 3H-aspartate, hea... | 40,384 | [
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[Institutional and personnel obstacles to the realisation of co-determination by old-age home inhabitants (author's transl)]. | Following the intentions of the "Heimgesetz" partizipation of the residents does not only concern a better protection of their interests, but also a change in the traditional, hierachical structure of organization of the homes for the aged. A realization of this aim is not only faced by the position of power of the man... | 40,445 | [
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[Therapy groups with patients and nursing staff in a geriatric hospital (author's transl)]. | Within a very short time the non-demented, chronically hospitalized old person turns into a hospital-activity-oriented patient. He thereby gives up a considerablle part of his personality. In order to understand this process, special attention has to be paid to the intertwining of the dynamics of the chronic geriatric ... | 40,446 | [
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Sexual development and activity of men with disturbances of somatic development. | By means of Questionnaires HTDM and SAM the heterosexual development and sexual activity were investigated in the following groups of males: 1. the control group consists of 345 married men from sterile marriages, who were adequately developed somatosexually, had normozoospermia in the ejaculate and a good potency; 2. ... | 40,461 | [
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[Postoperative analgesia by constant flow injection of lignocaine in obstetrical and gynecologic surgery]. | 154 surgical patients were given post-operative analgesia by peridural injection at a constant flow in the post-operative period after obstetric or gynecological surgery. These patients received 536.2 +/- 105.3 mu mol.h-1 (145.2 +/- 28.5 mg.h-1) of lignocaine for 46.97 +/- 15.56 h through a catheter omserted between L1... | 40,489 | [
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Effect of socio-environmental isolation on brain biochemistry, behaviour and psychoactive drug activity. | Isolation has been widely described to induce a strong aggressive behaviour in many animal species and especially in rodents. A deeper analysis of this altered behaviour induced by isolation, allows for the identification of several other changes involving numerous peripheral, behavioural and neurochemical functions. A... | 40,500 | [
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[Acute toxoplasmosis with necrotizing vasculitis (author's transl)]. | Acute toxoplasmosis was diagnosed in a Japanese woman aged 31 years after the discovery of a raised lysis titre and agglutinins resistant to 2-ME, as well as early increases in specific IgM followed later by increases in specific IgG. A high fever was present and signs of mainly distal polymyositis. The muscle lesion w... | 40,506 | [
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Isolation, characterization and the role of rabbit testicular arysulphatase A in fertilization. | Arysulphatase A was purified from rabbit testis. The purification was accomplished by a four-step procedure involving (NH4)2SO4 fractionation, chromatography on DEAE-cellulose, SP(sulphopropyl)-Sephadex and affinity chromatography on concanavalin A-Sepharose. The specific activity of purified preparation was 135 mumol/... | 40,545 | [
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Limited-turnover studies on proton translocation in reconstituted cytochrome c oxidase-containing vesicles. | We have investigated ferrocytochrome c-induced proton ejection from reconstituted cytochrome c oxidase-containing vesicles using careful control of the number of enzyme turnovers. Ferrocytochrome c caused the appearance of protons at the vesicle exterior, and this could be abolished by using a protonophore. In addition... | 40,547 | [
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Antianginal and haemodynamic effects of a new beta-blocking agent, SD 1601. | Seventeen patients suffering from angina pectoris were submitted to bicycle ergometer test until an ST ischemic segment of typical pain occurred. Before and during the effort the ECG was recorded: before and after the exercise, the systolic intervals were calculated and arterial pressure measured. The T.P. index, namel... | 40,567 | [
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Proestrus and metestrus rat uterus, a rapid and simple in vitro method for detecting histamine H2-receptor antagonism. | The antagonism caused by metiamide and cimetidine on histamine-induced inhibition of spontaneous and electrically stimulated isometric contractions of superfused rat uterine horns from proestrus and metestrus stages was studied in vitro. Histamine depressed smooth muscle "twitch" responses of spontaneously contracting ... | 40,581 | [
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Studies on the nature of the catalytically essential ionizing group of plasmin with pK 8.4. | A fully carbamylated derivative of plasminogen having no free amino groups has been prepared and converted by urokinase to an active enzyme, called carbamyl plasmin A, with a single free NH2-terminal amino group (Val-561). Carbamyl plasmin A was shown to possess a catalytically essential ionizing group having pK 8.6. C... | 40,605 | [
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... |
Purification and properties of a proteinaceous metallo-proteinase inhibitor from Streptomyces nigrescens TK-23. | A novel metallo-proteinase inhibitor which is capable of inhibiting the activities of metallo-proteinases such as the thermolysin, was isolated from the culture filtrates of Streptomyces nigrescens TK-23. The inhibitor was purified batch-wise from the culture filtrate by Amberlite IRC-50 and column chromatographies on ... | 40,611 | [
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... |
The effects of histamine on responses of the rabbit ear artery to electrical stimulation and to exogenous noradrenaline. | 1 The effects of a subconstrictor dose of histamine (9 x 10(-7) mol/l) on the responses of the isolated perfused ear artery of the rabbit to electrical stimulation (E.S.) and to exogenous noradrenaline (NA) were investigated.2 Both intraluminal (I/L) and extraluminal (E/L) histamine potentiated responses to E.S. and to... | 40,650 | [
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-0.1294165,
0.01516976,
-0.2769769,
-0.1927819,
-0.2631609,
0.00704508,
0.1849348,
-0.1684165,
0.4361441,
0.1042837,
-0.2296524,
-0.4095896,
0.006134151,
-0.5457335,
0.192858,
-0.226457,
0.1271437,
0.001045827,
-0.1163974,
0.2136129,
... |
A comparison of the effects of gamma-hydroxybutyrate and gamma-butyrolactone on cerebral carbohydrate metabolism. | The metabolic effects of 60-min exposure to 250-2000 mg gamma-hydroxybutyrate (GHB) per kilogram or 150-1200 mg gamma-butyrolactone (GBL) per kilogram were studied in rats by measurement of the cerebral hemisphere contents of energy phosphates and glycolytic-Krebs' cycle metabolites. A general pattern of increased glyc... | 40,677 | [
-0.03324125,
0.1154798,
-0.266401,
0.05122356,
0.1330063,
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0.257905,
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0.5293909,
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0.325855,
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0.3064609,
0.3218186,
... |
Fine-needle aspiration of the breast: diagnoses and pitfalls. A review of 3545 cases. | Fine-needle aspiration is now a recognized diagnostic tool. In the past eight years we have studied 3545 aspirates from the breast, including both cystic and solid masses. All were prepared according to the method of Papanicalaou. The cellular findings are described and discussed. Abnormal cells were found in the aspir... | 40,687 | [
-0.06236201,
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0.0892599,
0.168691,
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0.3853517,
0.1120844,
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... |
Characterization of an established cell line from human renal carcinoma. | A cell line, designated as OUR-10, has been established from a renal carcinoma in a Japanese woman. This cell line forms monolayers of polygonal epithelial cells with scattered round or dendritic cells and exhibits multilayering. With electron microscopy, differentiated surface structures that resemble the microvilli c... | 40,693 | [
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0.1131214,
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0.2086022,
0.3756967,
0.2118716,
0.3138873,
0.2748555,
-0.1132167,
0.22... |
A controlled study on the preventive effect of ketotifen, an antiallergic agent, on methacholine-induced bronchoconstriction in asthmatics. | We studied the preventive effect of ketotifen, an oral drug with antianaphylactic and antihistaminic properties on methacholine-induced bronchoconstriction in controlled cross-over experiments in twenty-six adult patients with extrinsic asthma. Both a single dose of 1 mg ketotifen and 4 weeks treatment of ketotifen, 1 ... | 40,709 | [
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0.1244779,
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0.1136507,
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0.06144838,
-0.1433052,
0.04651842,
-0.1065124,
0.04820175,
0.00241... |
Human erythrocyte thiol methyltransferase: radiochemical microassay and biochemical properties. | A radiochemical microassay for the measurement of thiol methyltransferase (TMT) activity in human red blood cell (RBC) membranes has been developed. Both 2-mercaptoethanol and dithiothreitol were used as substrates for the enzyme. The pH optimum of the reaction was approximately 9.0 when glycine NaOH was used as a buff... | 40,715 | [
-0.129594,
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0.6291063,
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0.08282768,
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... |
A rare cause of ischemic colitis: polyarteritis nodosa. | This paper details the first case report of a patient with fulminant, gangrenous, ischemic colitis caused by polyarteritis nodosa which was successfully treated surgically. Ischemic colitis is a rare complication of polyarteritis nodosa. It should be suspected in patients with a past history of polyarteritis nodosa who... | 40,759 | [
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0.06280918,
0.08615174,
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0.2554982,
0.3441932,
-0.195397,... |
Role of enterohepatic circulation in the analgesic action of 1-alpha-acetylmethadol in the rat. | The enterohepatic circulation of 1-alpha-acetylmethadol (LAAM) was investigated in the rat. Bile containing 3H-LAAM metabolites was collected from a biliary cannulated donor rat after administration of 3H-LAAM (5 mg/kg, 15 muCi/kg, sc) and infused into the intestine of a double biliary-cannulated recipient rat for 1 hr... | 40,771 | [
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0.09082478,
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0.2257064,
0.1257993,
0.1724642,
-0.1059483,
... |
Metabolic fate of phenobarbital in man. N-Glucoside formation. | 1-(beta-D-Glucopyranosyl)phenobarbital was identified as the major metabolite of phenobarbital in man. Proof of structure was based on the comparison of the UV, NMR, and mass spectrometry and TLC data for the acetylated metabolite with an authentic compound. The previous erroneous structure assignment of this metabolit... | 40,773 | [
0.07499042,
0.3796973,
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0.5061496,
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0.214766,
0.2237125,
0.4600197,
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-0.... |
Blood pressure and plasma noradrenaline during single high-dose beta adrenoceptor blockade. | The acute effects upon blood pressure and sympathetic outflow of two beta adrenoceptor blocking drugs, propranolol and atenolol, are described in five healthy normotensive subjects. Supine blood pressure, heart rate, plasma noradrenaline, and urinary catecholamine excretion were measured before and at intervals for 24 ... | 40,797 | [
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0.07636666,
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0.07023228,
0.003787406,
0.1597999,
-0.04722343,
0.2708124,
0.00659427... |
Consultation evaluation: I. Psychotropic drug recommendations. | A follow-up chart review was undertaken of 100 consecutive patients seen in psychiatric consultation for whom psychotropic medication was recommended. Significant differences in implementation (P less than 0.01) by class of drugs (neuroleptics, tricyclics, benzodiazepines) were found. Most often no discernible reason f... | 40,844 | [
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0.2242317,
0.045728,
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0.2418004,
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0.2983173,
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0.4310625,
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0.2478712,
-0.1731135,
-0.09926796,
-0.1075272,
-0.... |
Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone. | Prostaglandin synthetase activity in rectal biopsy specimens from patients with ulcerative colitis has been shown to fall on treatment with sulphasalazine, local steroids, and codeine phosphate. In vitro studies have shown that sulphasalazine is an inhibitor of prostaglandin synthetase, although less potent than indome... | 40,848 | [
-0.1179598,
-0.08959187,
-0.1823731,
0.1418249,
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0.0662306,
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0.02687073,
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0.2872495,
-0.03140768,
-0.0937264,
0.4473299,
0.1074314,
0.1030302,
0.02216574,
... |
Human platelet arylsulphatases: identification and capacity to destroy SRS-A. | Arylsulphatases IIA and IIB have been separately identified in human platelets by use of anion exchange chromatography and gel filtration. Arylsulphatase IIA had a molecular weight of 160,000 and a pH optimum of 4.5. Arylsulphatase IIB had a molecular weight of 60,000 and a pH optimum of 5.5. Both arylsulphatases IIA a... | 40,872 | [
0.009782543,
0.1212707,
-0.4451916,
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0.2122456,
0.06915819,
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0.06738622,
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0.1097939,
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0.0215541,
0.05141073,
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-0.3892686,
0.3499131,
0.1639924,
0.1416825,
-0.03417889,
-0.0415... |
Immunochemical cross-reactions between type III group B Streptococcus and type 14 Streptococcus pneumoniae. | Serological cross-reactions between certain streptococci and some serotypes of Streptococcus pneumoniae have been reported. These studies detail the serological cross-reactivity observed between hot HCl-extracted group b streptococcus type III (GBS III) antigens and S. pneumoniae type 14 (Pn 14) polysaccharide. Similar... | 40,876 | [
-0.1098804,
0.1450361,
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0.177463,
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0.2424352,
-0.2138626,
0.1158799,
0.3233864,
0.2498014,
-0.2603195,
... |
Large-scale production and physicochemical characterization of human immune interferon. | Large-scale production of crude high-titered (10(2.3) to 10(4) U/ml) human immune interferon (type II) was carried out in roller bottle cultures of human peripheral lymphocytes by using the T-cell mitogen staphylococcal enterotoxin A. Over 99% of human immune interferon was destroyed by pH 2 or heat at 56 degrees C for... | 40,881 | [
-0.1522495,
0.1566036,
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0.1540287,
0.08730756,
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0.5030406,
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0.132549,
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0.06319721,
0.4487571,
0.509975,
-0.05652387,
-0.1317399,
... |
Attachment pili from enterotoxigenic Escherichia coli pathogenic for humans. | Pili from enterotoxigenic Escherichia coli pathogenic for humans have been isolated by adsorption to the surface of erythrocytes followed by thermal elution. The pili are composed of two protein subunits with molecular weights of 13,100 and 12,500 as determined by sodium dodecyl sulfate-gel electrophoresis. These pili ... | 40,882 | [
-0.2408523,
-0.02823907,
-0.1789909,
-0.03623238,
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0.0416134,
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0.1409947,
0.2366678,
0.3848241,
-0.2169... |
A calorimetric study of the interaction of ATP with rabbit muscle phosphofructokinase. | The heat of interaction of ATP with phosphofructokinase from rabbit muscle was determined at 25 degrees C in 0.1 M potassium phosphate, pH 7.0 and 8.0. The limiting value of the enthalpy change at high ATP concentrations was found to be -11.5 kcal mol of enzyme polypeptide chains. Since phosphate and imidazole have ver... | 40,994 | [
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0.02837652,
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0.2975115,
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0.009364011,
0.0790657,
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0.02204564,
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0.08151215,
0.5416558,
0.04117347,
0.0008801294,
... |
Precise spectrophotometry of small quantities of drugs in the presence of irreproducible quantities of impurities. | A variety of methods of spectrophotometric assay of compounds in the presence of one or more irrelevant impurities have been recently described, employing, for example, the use of Legendre polynomials and trigonometric functions. The use of least-squares solutions of overdetermined systems (Scheid 1968) in spectrophoto... | 41,037 | [
-0.02624597,
0.205908,
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0.04257009,
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0.3360071,
0.3696475,
-0.1442465,
0.02112469,
0.082... |
The use of phospholipid liposomes for lithium administration. Polydipsic effect and tissue distribution of lithium. | Administration of lithium entrapped in phospholipid liposomes increased the lithium-induced polydipsia, but did not accelerate the onset of this effect. It also resulted in a larger accumulation of lithium in the liver, kidney and spleen, but not in the brain. The time course of polydipsia suggests that it depends on t... | 41,065 | [
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0.08701625,
0.3879983,
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0.1581185,
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0.2937122,
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0.1409833,
0.03474037,
0.02079164,
0.3354262,
0.2612039,
-0.04745692,
... |
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