title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Transplacental passage of cells from mother to fetus: experimental approach and initial results in the rat]. | The consequences of transfusion across the placenta of maternal cells to fetuses, supposed to elicit a Graft-Versus-Host-Reaction, are poorly investigated; the injection of pregnant rat whole blood cells to its own fetuses is proposed here as a convenient experimental model to improve the understanding of these consequ... | 45,257 | [
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Microspectrofluorometric studies on the formaldehyde-induced reaction product of 5-hydroxytryptamine. | A new model incorporating Sephadex G-25 as an inert carrier has been developed for studying the reaction between biogenic amines and formaldehyde vapour. Both the fluorescence yield and the spectral characteristics of the 5-HT formaldehyde reaction product are influenced appreciably by the relative humidity at which pa... | 45,274 | [
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[Sympathetic mediation of induced and spontaneous activity of the pelvis-ureter in vitro]. | The spontaneous activity of guinea-pig renal pelvis-ureter is regulated by the adrenergic system. Spontaneous rhythmic contractions, and contractions induced by Noradrenaline are inhibited by Dihidroergotamine and Phentolamine. Alpha-adrenergic blocking agents block also contractions induced by histamine, angiotensin a... | 45,305 | [
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[Postvaccinal encephalitis in adult. A case with anatomo-clinical report (author's transl)]. | While post-vaccinal encephalitis in children is unfortunately well known, its occurrence in adults is rather exceptional. The calendar of a poly vaccination situated so close to each other, most probably account for such an evolution. The case reported concerns a man of 27 years who presented 10 days after a polyvaccin... | 45,321 | [
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[The development of psychopharmacotherapy]. | Based on experiences during the longterm treatment with psychotropic drugs the following subjects are discussed: extrapyramidal side effects of neuroleptic drugs, cardiovascular side effects of antidepressants, side effects of Lithium, interactions with other medications, influence on laboratory tests and also the psyc... | 45,344 | [
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Viability of some Salmonella strains in Algerian eggs. | Whole-egg and egg-white were inoculated with S. typhi murium, S. dublin, S. oranienburg and S. oslo separately and were stored at - 1 degrees C, + 4 degrees C and 26-28 degrees C. pH value was determined every day as well as the survival of the different inoculated Salmonella strains till the end of the experiment. Sto... | 45,429 | [
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Isolation, cryopreservation, and autotransplantation of human stem cells. | We have used cryopreserved autologous hematopoietic cells to repopulate bone marrow of patients receiving intensive chemotherapy and radiation. We employed the technique of density step centrifugation to concentrate stem cells from whole bone marrow. The concentrate of cells was frozen in vials using dimethyl sulphoxid... | 45,456 | [
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Neuroendocrine modulation of calcitonin and parathyroid hormone in man. | Recent evidence suggests that of calcitonin (CT) and parathyroid hormone (PTH) is controlled by factors other than the ambient serum calcium concentration. We studied the effects of infusions of four neuroendocrine modulators upon CT and PTH levels: isoproterenol (beta-adrenergic agonist), methoxamine (alpha adrenergic... | 45,460 | [
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Failure of alpha-methyltyrosine to inhibit peripheral triiodothyronine formation. | To determine if the adrenergic nervous system, and specifically tyrosine hydroxylase, plays a role in the extrathyroidal conversion of T4 to T3, normal male volunteers were treated with T4 and subsequently with T4 and alpha-methyl-p-tyrosine (alpha-MPT), an inhibitor of tyrosine hydroxylase, for 2 weeks. The mean serum... | 45,464 | [
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The arteriographic manifestations of Takayasu's arteritis in children. | Eighteen cases of Takayasu's arteritis in children under 14 years of age are described, emphasising the arteriographic features and noting differences with other series. Renal artery stenosis resulting in renal hypertension was the most significant finding but widespread involvement of the aorta and its main branches w... | 45,479 | [
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Mandibular fractures. II. A follow-up study of 229 patients. | During the period 1964-73, 286 patients were treated for mandibular fractures. 229 patients (80%) attended the follow-up examination. The length of observation was from 1 to 9 years. The treatment and the follow-up evaluations in the 229 patients are described. Early fracture treatment has been the objective, also in p... | 45,484 | [
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Two pools of glycogen in Saccharomyces. | The effect of different extraction procedures on the yields of water-soluble and water-insoluble glycogen fractions from a number of Saccharomyces strains was studied by using a specific method for glycogen determination. The similarity of the yields obtained by the different procedures showed that neither form of glyc... | 45,487 | [
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The value of pulsus paradoxus in assessing the child with status asthmaticus. | The presence of pulsus paradoxus (PP) in 13 episodes of status asthmaticus in 12 children, ages 13 months to 15 years, was compared sequentially to a clinical score, peak expiratory flow rate (PEFR), heart rate, arterialized capillary pH, carbon dioxide pressure (PCO2), and the ratio of inspired oxygen to oxygen pressu... | 45,490 | [
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Assessment of clinical laboratory techniques in the measurement of oxygen saturation in whole blood. | The accuracy and advantages of determining percentage of hemoglobin oxygen saturation of whole blood by advanced instruments of oximetry, gas chromatography, and the computation of oxygen saturation from pO2 and pH data are compared with the Van Slyke-Neill manometric method. It was found that oximetry is extremely fas... | 45,493 | [
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Purification and properties of beta-lactamase from Bacteroides fragilis. | Beta-Lactamase activity was detected either biologically or using the chromogenic cephalosporin 87/312 in 20 clinical isolates of Bacteroides fragilis with penicillin G minimal inhibitory concentrations of 10 to 100 micrograms/ml. Strain AM78 (minimal inhibitory concentration, greater than 1,000 micrograms/ml) was used... | 45,494 | [
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Role of a radiologic technologist trained as a physician assistant in diagnostic radiology. | This article describes a program for physican assistants in diagnostic radiology at the University of Kentucky, currently the only one in the country. Available only to graduates of AMA-approved radiologic technology programs who have two years of field experience, it consists of two additional years of intensive educa... | 45,504 | [
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A perspective: the external degree as a viable educational model in nursing. | The external degree is not new in higher education. However it has not as yet been fully developed. Its usefulness has been demonstrated at the undergraduate level where students are able to move up the career ladder to licensure or degree. It appears to be a viable alternative for nurses seeking educations at the mast... | 45,509 | [
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Head-to-head association in bovine spermatozoa induced by catecholamines. | Noradrenaline, adrenaline, and isoproterenol induce head-to-head association in bovine spermatozoa in a Tris-HCl-buffered medium. Noradrenaline was the most and isoproterenol the least efficient. This effect was stimulated by Ca2+, Mg2+ and Mn2+, Ca2+ being more efficient than the other two ions. At 2 X 10(-6) M Ca2+, ... | 45,520 | [
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Glutamine synthetase in kidneys of monkey and man. | 1. The synthesis of gamma-glutamylhydroxamate from glutamate and hydroxylamine has been utilized as an approximation of glutamine synthetase activity in kidneys of rabbit, rat, dog, monkey and man. 2. Kidneys of rabbit contain glutamine synthetase in high activity; those of rat, in intermediate activity; and those of d... | 45,541 | [
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Preliminary characterization of the delta-9 desaturase of Tetrahymena pyriformis W. | 1. In vitro assay conditions have been defined for measurement of delta 9 desaturase activity in Tetrahymena pyriformis W. 2. The reaction depends on the presence of oxygen and a reduced pyridine nucleotide cofactor. FAD supports a low level of enzymatic activity. 3. Both stearyl-CoA and palmityl-CoA are acceptable sub... | 45,543 | [
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Characteristics of delta 1-pyrroline-5-carboxylate reductase from Drosophila melanogaster. | 1. Biochemical properties of delta 1-pyrroline-5-carboxylate reductase from d. melanogaster have been investigated. 2. The enzyme is stable below 4 degrees C. 3. the pH optimum of the enzyme is 5.7. It is rapidly inactivated below pH 5.4. 4. The Km values for NADPH and delta 1-pyrroline-5-carboxylate are 1.6 x 10-5 and... | 45,549 | [
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Alanine aminopeptidase activity and autolysis in the tails of Rana catesbeiana larvae during metamorphosis. | 1. Alanine aminopeptidase activity and autolysis increase concomitantly in tail tissue of Rana catesbeiana tadpoles during metamorphosis. 2. significant increases first appear at Taylor and Kollros state XX and coincide with the beginning of tail regression as determined by the tail wt body wt ration. 3. The results su... | 45,550 | [
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Biochemical studies of supernatant malate dehydrogenase allozymes in Drosophila melanogaster. | 1. A biochemical comparison was made among cytoplasmic malate dehydrogenase allozymic variants from Drosophila melanogaster. Experiments were carried out on enzyme extracted from six different genotypes: three homozygotes and their respective heterozygotes. 2. The allozyme forms (MDH A, MDH B, MDH C) were indistinguish... | 45,555 | [
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Metabolic changes in Crithidia fasciculata accompanying physiological adaptation to growth in the presence of carbonyl cyanide m-chlorophenylhydrazone. | 1. Crithidia fasciculata adapted to growth in the presence of 10(-5) M carbonyl cyanide m-chlorophenylhydrazone (CCCP), an uncoupler of oxidative phosphorylation, maintained adenosine phosphate pools and an adenylate energy charge comparable to those of control cells. 2. CCCP-adapted cells in the presence of the uncoup... | 45,556 | [
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Perspectives in chemotherapy of schizophrenic psychoses. | 1. The treatment of schizophrenic symptoms has not the same efficacy in acute and chronic phases of the disease and on the various target symptoms of schizophrenia. 2. The ideal antipsychotic drug might have different properties, sometimes contradictory, to be effective both on paranoid and hebephrenic symptoms which s... | 45,563 | [
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AHR-6646: a new, long-acting neuroleptic. | 1. AHR-6646 blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. 2. Conditioned avoidance responding in mice and cats was suppressed by AHR-6646 in doses that did not impair escape behavior. The duration of this effect was markedly prolo... | 45,570 | [
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Teichoic acids of group D streptococci with special reference to strains from pig meningitis (Streptococcus suis). | Immunoelectrophoresis revealed in phenol extracts from S. faecalis and S. faecium a mixture of free and lipid-bound teichoic acids, both reactive with Group D antisera. In phenol extracts from S. suis only lipid-bound teichoic acid, also reactive with Group D antiserum, was seen. This difference probably accounts for t... | 45,589 | [
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The homogeneity of the faecal coliform flora of normal school-girls, characterized by serological and biochemical properties. | The homogeneity of fecal coliform flora in 52 schoolgirls was studied by serotyping and biotyping 10 randomly selected colonies in one fecal culture from each child. Ninety-eight clones were identified and of these 52 were dominant and 46 were minor strains. The probability of including at least one isolate of the domi... | 45,599 | [
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0.2854342,
0.04126514,
0.3091656,
0.2649955,
0.4451137,
0.007934311,
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A comparison of staphylococcal nasal carrier rates in Germany and Poland. | Frequencies of different staphylococcal nasal carrier classes were studied in groups of students of nursing and of laboratory personnel in Cologne, West Germany, and in Krakow, Poland, by six consecutive samplings of their nasal vestibules. The general number of persistent carriers of S. aureus appeared to be lower tha... | 45,603 | [
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Metabolism of oestradiol by human mammary tumour 800 x g supernatants pretreated with dihydrolipoic acid. | Incubation of human mammary tumour 800 x g supernatants with [3H]oestradiol after preincubation for 10 min at 0 degrees C with 10 mM dihydrolipoic acid resulted in metabolism of oestradiol. This was noted in 12 malignant tumours, 8 of which contained measurable oestrogen receptor levels. In 2 benign tumours lacking mea... | 45,733 | [
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Effect of cardiotonic and vasoactive drugs on transmural flow distribution and ventricular volume in the fibrillating heart on cardiopulmonary bypass. | Subendocardial hemorrhagic necrosis in an important cause of death following cardiopulmonary bypass. The transmural distribution of flow across the left ventricle (LV), septum (SP), and right ventricle (RV) is a complex interaction of vascular resistance and myocardial compressive resistance. We studied the change in t... | 45,821 | [
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0.008... |
Histochemical and biophysical study of cuticle sclerotization in Pycnoscelus surinamensis L. (Blattaria). | The problem of melaninogenesis and quinone tanning of the cuticle was examined by histochemical and biophysical methods (electroparamagnetic resonance: EPR) on normal subjects of Pycnoscelus surinamensis and on subjects with abnormal cuticular colour. The cuticle of abnormal subjects showed a lower content of polypheno... | 45,833 | [
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Evaluation of cardiovascular and pulmonary changes during meperidine-diazepam anesthesia. | Studies were conducted in 189 oral surgery out-patients to evaluate the combination of meperidine hydrochloride and diazepam for anesthesia and to determine its effect on the cardiovascular and pulmonary systems. Results showed that neither ventricular cardiac arrhythmias nor clinically significant respiratory depressi... | 45,841 | [
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Normal and altered phenotypic expression of immunoglobulin genes. | Genetically controlled intraspecific differences between immunoglobulins (allotypes) provide valuable markers for the study of the quantitative expression of allelic and nonallelic alternative forms of immunoglobulins (Igs) during the normal development of rabbits. Heterozygous rabbits are mosaics of cells expressing d... | 45,857 | [
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Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents. | The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative ... | 45,881 | [
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Human sleep and EEG through a cycle of methadone dependence. | The effects of oral methadone on EEG and sleep were studied in 6 male postaddicts. Continuous nocturnal measurement of EEG, EMG and EOG was used to define sleep patterns. Period analysis and power spectral analysis were performed on each 8 min sample of daytime (eyes closed) EEG. Both sleep and EEG were studied during ... | 45,902 | [
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[An electrophysiological study of direct occipito-frontal connections in centrum semi-ovale of Papio papio]. | 1. Evoked responses to single visual stimuli (VEP) and driving by intermittent light stimulation (ILS) were recorded with macroelectrodes from the central white matter (centrum semiovale) of 12 Papio papio baboons. 2. Two types of VEP were identified: VEPs with constant morphology, localized in the long associative bun... | 45,946 | [
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Selective averaging of the intracerebral click evoked responses in man: an improved method of measuring latencies and amplitudes. | Individual click evoked responses recorded in the right and left frontal lobe in man have been correlated with different templates, that is, particular wave shapes of evoked responses, and from the maxima of the cross correlation functions individual estimates were obtained of amplitude and latency. Averages were then ... | 45,950 | [
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Bacterial colonisation of jejunal mucosa in acute tropical sprue. | Fifteen of sixteen Caucasians with acute tropical sprue were founc to have numerous aerobic bacteria closely associated with the mucosal layer of the proximal jejunum. Four species of Enterobacteria were grown in eleven patients, and concentrations were higher in the mucosal patients than in the jejunal fluid. Only one... | 46,020 | [
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The small-intestinal mucosa in cow's milk allergy. | Two infants investigated for allergy to cow's milk proteins exhibited a local reaginic reaction in the small intestine after ingesting cow's milk, as shown by increased mucosal IgE plasma-cells and degranulation of mast cells. IgM plasma-cells and the staining of connective tissue and basement membranes with antisera t... | 46,052 | [
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Mucosal histochemistry in secretory otitis. | Mucosal biopsies were taken from 20 ears with secretory otitis media (glue ear) and histochemical stainings were made for comparison with data obtained from biochemical analysis of the fluids. Acid phosphatase, lactate dehydrogenase (LD), and malate dehydrogenase (MD), the activity of which in the ear fluids was 20 to ... | 46,141 | [
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Biological importance of retrograde axonal transport of nerve growth factor in adrenergic neurons. | Previous studies have shown that nerve growth factor (NGF) produces a selective induction of tyrosine hydroxylase (TH) in peripheral adrenergic neurons and that NGF is transported retrogradely with a high selectivity from the adrenergic nerve terminals to the perikaryon. In order to investigate the biological importanc... | 46,156 | [
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Concealed extrasystolic ventricular bigeminy with interpolation. | The first reported case of concealed extrasystolic ventricular bigeminy with interpolation is described. This arrhythmia is characterized by the presence of both interpolated ventricular extrasystolic beats and a presumed persistent and continuous bigeminal ectopic rhythm with exit block. The distributional pattern of ... | 46,194 | [
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Purification, characterization and radioimmunoassay of thyrocalcitonin from rat thyroid glands. | A highly purified preparation of rat thyrocalcitonin (TCT) has been obtained from lyophilized thyroid glands by gel chromatography following acid-acetone extraction. Biological activity of Sephadex G-50 eluates appeared in two peaks. The TCT in the major peak was concentrated, and applied to a Bio-Gel P-6 column, and a... | 46,198 | [
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Transposition with ventricular septal defect and pulmonary stenosis: the Rastelli operation. | A total of 52 Rastelli operations have been performed at the Mayo Clinic for transposition of the great arteries with ventricular septal defect and pulmonary stenosis. Of the 43 patients over four years of age, two died (5%). A much higher mortality among younger children, in our earlier experience, led to a policy of ... | 46,225 | [
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Energy coupling in the uptake of hexose phosphates by Escherichia coli. | Several methods were used to study the source of energy in the uptake of hexose phosphates by Escherichia coli K12. The uptake was sensitive to inhibition by agents that affect electron transport, such as lack of oxygen, cyanide, and heptylhydroxyquinoline-N-oxide, and by agents that affect ATP utilization, such as dic... | 46,228 | [
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IgA and IgA diphtheria antitoxin responses from human tonsil lymphocytes. | Human tonsil lymphocytes were stimulated with diphtheria toxoid and then cultured in a Marbrook culture system so that antibodies could be measured in the culture supernatant. Specific antibodies were measured with excess radiolabeled antigen and antisera specific for each immunoglobulin class. Good IgG and IgA diphthe... | 46,260 | [
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Complement-mediated release of histamine from human leukocytes. | Activation of either the alternative or classical pathway of complement generated a factor which induced release of histamine from both non-allergic and allergic human basophils. This factor probably is derived from the complement system since 1) its formation was associated with loss of C3 activity in human serum, 2) ... | 46,261 | [
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Antigenic characterization of type C RNA virus isolates of gibbon apes. | Type C RNA viruses initially isolated from a lymphosarcoma of a gibbon ape and from a fibrosarcoma of a woolly monkey are very closely related immunologically. However, recent studies have shown that these viruses are distinguishable in a radioimmunoassay for the 12,000-molecular-weight polypeptide (p12) of the woolly ... | 46,280 | [
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RNA-dependent DNA polymerase activity of RNA tumor viruses. V. Rous sarcoma virus single-stranded RNA-DNA covalent hybrids in infected chicken embryo fibroblast cells. | RNA-DNA covalent hybrids containing viral RNA have been isolated from nuclear fractions of Rous sarcoma virus-infected chicken embryo fibroblast cells shortly after virus infection. The formation of covalent hybrid structures depends upon a functional reverse transcriptase in vivo, since its appearance in cells is temp... | 46,286 | [
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George Washington University technique for surgical correction of post-prostatectomy incontinence. | We have described a procedure with long-term followup and modification for the correction of post-prostatectomy incontinence. The procedure involves the combined principle of rigidly placed support under the urethra to which is attached an inflatable, adjustable pillow, allowing for fine control of the urethral resist... | 46,289 | [
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Incidence and nature of cytoplasmic hepatitis B antigen in hepatocytes. | Hepatitis B antigen (HB Ag) in the hepatocytic cytoplasm is detected by immunofluorescence after reaction with fluoresceinated antiserum to HB Ag or by electron microscopy as numerous 20- to 30-nm. tubular and circular structures in dilated cisternae of excess endoplasmic reticulum. On light microscopy, these hepatocyt... | 46,330 | [
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Current status of the surgical treatment of truncus arteriosus. | Persistent truncus asteriosus is now correctable surgically in patients with favorable anatomy. Given pulmonary arteries of reasonable size arising from any source, successful correction is possible so long as irreversible pulmonary vascular disease has not occurred. Although the majority of children with this defect d... | 46,332 | [
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The essential role of glucagon in the pathogenesis of diabetes mellitus. | The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatect... | 46,337 | [
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Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins. This finding supports existing evidence that H.D.L. facilitates the uptake of cholesterol from peripheral tissues and its transport to t... | 46,338 | [
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... |
Mechanical deficiencies in scintillation counters, scanners, and gamma cameras. | After an accident involving a scintillation counter, the machanical integrity of scintillation counters and their stands, rectilinear scanners, and gamma cameras was examined. An alarming proportion of these divices were found to be poorly designed with consequent danger to patients and staff. This class of equipment s... | 46,346 | [
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... |
New approach to management of intracranial aneurysms. | In six cases an attempt was made to relieve the tension on intracranial aneurysms by temporarily clamping the internal carotid artery in the neck, so as to increase the expansibility of the artery. This approach was based on the concept (or "A principle") that haemorrhage is caused by the aneurysm having to bear the fu... | 46,379 | [
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Insulin responses to oral carbohydrate in true prediabetics and matched controls. | The definition of prediabetes by genetic criteria alone has limitations since not all such subjects progress to overt diabetes. Sequential oral glucose tolerance testing in a population has enabled the identification of 14 "true prediabetic" subjects with baseline two-hour plasma glucose levels smaller than 160 mg. pe... | 46,445 | [
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Person-to-person spread of Salmonella typhimurium after a hospital common-source outbreak. | In September, 1973, diarrhoea caused by Salmonella typhimurium developed in 32 people in a Maine hospital. Both epidemiological and microbiological evidence indicated that raw egg beaten in milk ("egg-nog") was responsible for the infection. However, 6 patients and 8 employees had not had egg-nog, and their illness d... | 46,457 | [
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Alveolar rhabdomyosarcoma of the ethmoid sinus. | A case of the alveolar rhabdomyosarcoma originating in the left ethmoid sinus was reported. Despite treatment by radical excision of the tumor, irradiation and chemotherapy, the patient died of generalized metastases of the tumor six months after surgery; however, no local recurrence of the tumor was found at an autops... | 46,581 | [
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Chemotherapeutic drugs increase killing of tumor cells by antibody and complement. | When the ascitic forms of two antigenically distinct guinea pig hepatomas induced by diethylnitrosamine are treated in vitro with chemotherapeutic drugs, their sensitivity to killing by xenogeneic antibody plus guinea pig complement increases. The effect is dependent on drug dose, is reversible, and does not appear to ... | 46,622 | [
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Use of peroxidatic-enzyme staining to enhance resolution of cultured mammalian cells under phase microscopy. | Staining of glutaraldehyde-fixed mammalian cells with peroxidatic enzymes (horseradish peroxidase or horse heart cytochrome c) greatly enhances resolution of their structure under phase microscopy. The topography of cell processes and regions of intercellular contact and overlapping is resolved precisely, even in dense... | 46,631 | [
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Cytological differentiation of asymptomatic pancreatic islet cell tumours in autopsy material. | In eleven cases thirteen pancreatic islet cell adenomas were found in autopsy material from 1366 adult cases. Ten of the adenomas were solitary, while 3 small adenomas were observed in a single case. Another four possible solitary adenomas were observed, but their identity was uncertain owing to marked fibrosis. All th... | 46,649 | [
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Limitations of the usefulness of the d-xylose absorption test. | The results of the conventional 5-hour d-xylose absorption test were surveyed in 38 subjects with disease of the jejunal mucosa, giardiasis or bacterial overgrowth, or no small-bowel disorder. The test was in error in 20-40% of cases, depending on the disease category, and the error for the entire group was 30%. We con... | 46,695 | [
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Changes in the ratio between serum and "specific" levels of human chorionic gonadotropin in different trimesters of pregnancy. | Sixty-one sera from different trimesters of pregnancy were analyzed by two 125-I-NIH-HCG assay systems, employing anti-intact HCG serum and anti theta-HCG serum, respectively. The ratios of the levels measured in the two assay systems changed with the duration of pregnancy. The ratios during trimesters 1,2, and 3 were ... | 46,715 | [
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Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. | Radioimmunoassays and bioassays based on the reactions of the native molecule of human chorionic gonadotropin (HCG) fail to differentiate HCG from pituitary luteinizing hormone (LH). An assay based on the beta-subunit of HCG which detects HCG exclusively has been used in our laboratory to monitor patients undergoing ch... | 46,716 | [
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Genetic studies in the Markham Valley, northeastern Papua New Guinea: gamma globulin (Gm and Inv), group specific component (Gc) and ceruloplasmin (Cp) typing. | Genetic studies in the Markham Valley, northeastern Papua New Guinea; Gamma globulin (Gm and Inv), group specific component (Gc) and ceruloplasmin (Cp) typing. M. S. Schanfield, Eugene Giles and H. Gershowitz, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48104. Immunoglobulin allotyping was... | 46,722 | [
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The roentgenographic and clinical findings in Whipple's disease. A review of 8 patients. | Out of 8 patients with Whipple's disease, 7 had roentgenographic findings consisting of slight dilatation of the small bowel, with thickening of the mucosal folds. The eighth patient had no abnormality on roentgenographic study. This series represents the first in which the roentgenographic changes have been quantita... | 46,724 | [
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Affinity of cellular constituents of two bacteria for fluorescent brighteners. | Two fluorescent brighteners were used to stain an isolate of Bacillus cereus var. mycoides and soil pseudomonad. The stained organisms were fractionated by two procedures to determine which cellular constituents were reacting with the brighteners. Both fractionation procedures provided evidence that the brighteners w... | 46,739 | [
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Cultivation of leukemic human bone marrow cells in diffusion chambers implanted into normal and irradiated mice. | In order to elucidate the question of whether the maturation defect in vivo in acute leukemia is due to environmental or cellular factors, we have cultured human leukemic cells in a nonleukemic milieu, i.e., diffusion chambers implanted into the abdominal cavity of normal and irradiated mice. For each harvest, the cell... | 46,761 | [
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An adrenergic component of the nervous apparatus of the aortic reflexogenic zone. | The structural organization of the adrenergic (sympathetic) component of the autonomic innervation of the depressor zone of the cat aortic arch was studied by luminescence microscopy of the catecholamines. A terminal adrenergic plexus, branching extensively in the connective-tissue basis of the depressor area of the ao... | 46,763 | [
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Time course of development of supersensitivity to topical acetylcholine in partially isolated cortex. | In alert monkeys the time course for development of supersensitivity to topical acetylcholine in partially isolated frontal cerebral cortex was determined. Thresholds for paroxysmal discharge fell progressively and markedly during 3 weeks, further in 5 and somewhat more after 6 months. ACh supersensitivity was demonstr... | 46,800 | [
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EEG correlates of visual-motor practice in man. | Special analysis of EEG signals was performed for 15 subjects engaged in three motor tasks of differing difficulty. A measure of average weighted coherence (C) was computed between the six possible combinations of four scalp areas: Oz, C3, C4 and Fz. In all subjects, regardless of task, scalp recordings over cortical a... | 46,821 | [
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Use of the analytical electron microscope (AEM) in cytochemical studies of the central nervous system. | Central nervous tissues (median eminence and arcuate nucleus) were studied by means of energy dispersive x-ray analysis using electron optical systems (analytical electron microscopy). These studies were conducted after the tissue had been treated specifically for localized biogenic amines (BA). The results indicate th... | 46,860 | [
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Optical versus radiographic magnification for fine-detail skeletal radiography. | Fine-detail radiographic techniques for peripheral skeletal imaging have gained wide clinical acceptance. In this study, the imaging properties and clinical applications of the optical magnification technique, which employs fine-grain industrial film and a large focal spot, are compared quantitatively and qualitatively... | 46,857 | [
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Role of the eosinophil in the allergic reactions. I. EDI-an eosinophil-derived inhibitor of histamine release. | An inhibitor of histamine release was found to be associated with the human eosinophilic leukocyte. This eosinophil-derived inhibitor (EDI) was released from eosinophil-rich fractions upon sonication or interaction with immune reactants (specific allergens or anti-IgE). EDI was found to exert its inhibitory action at t... | 46,900 | [
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Amines, anticonvulsants, and epilepsy. | Concentrations of 5-hydroxyindoleacetic acid (5-H.I.A.T.) in cerebrospinal fluid (C.S.F.) were significantly raised in twenty-seven anticonvulsant-treated epileptic patients compared with fifteen untreated epileptics and twenty-two neurological controls. This rise was not seen until therapeutic blood-levels of phenobar... | 46,954 | [
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Assessment of outcome after severe brain damage. | Persisting disability after brain damage usually comprises both mental and physical handicap. The mental component is often the more important in contributing to overall social disability. Lack of an objective scale leads to vague and over-optimistic estimates of outcome, which obscure the ultimate results of early m... | 46,957 | [
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Costs of detecting and treating cancer of the uterine cervix in North-East Scotland in 1971. | In 1971 the Aberdeen cytology service handled 22,291 cervical smears--threequarters from women participating in a screening programme and the rest from women with symptoms who were referred to hospital. As a result of screening, 56 preclinical cases of cancer of the cervix uteri were treated in hospital; 13 others wer... | 47,092 | [
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0.009509343... |
[Experimental malakoplakia in the kidney]. | Malakoplakia in kidney of rats was caused experimentally by injection of large quantities of not purified endotoxin-antigen complex of Escherichia coli 0 75 (O. coli 127 97 CDC 0 group 75; American Type Culture Collection, Eight Edition 1968, page 24). The extract in the beginning became surrounded by leukocytes, later... | 47,145 | [
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0.2220263,
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Induction of translocations by cyclophosphamide in different germ cell stages of male mice: cytological characterization and transmission. | Cytological and fertility tests were performed in F1 male mice derived from different germ-cell stages of male parents treated with cyclophosphamide (350 mg/kg body weight). The objectives of the present experiment were: (I) to determine the sensitivity of the male germ-cell stages to the induction of translocations by... | 47,147 | [
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Double-blind study of the analgesic effect of indoprofen (K 4277). | In a double-blind study, indoprofen was superior to placebo in decreasing pain in patients with primary and metastatic cancer and with neuralgia. A single oral dose of 200 mg was more active than a 100-mg dose. The preferences of patients proved to be a more sensitive parameter in this study than scores of pain intensi... | 47,280 | [
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0.1879811,
0.0851418... |
Retardation of development including immunogenic expression of histocompatibility antigens in mice--by postnatal administration of antiandrogenic steroid. | A specific antiandrogenic steroid cyproterone acetate was administered daily to mice of three different inbred strains starting from the day of birth until the age of 30 days. The total dose per mouse was 17.2 mg. This treatment resulted in developmental retardation which was manifested in a number of ways: at the age ... | 47,300 | [
0.09539729,
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-0.186... |
Genetic control of sensitization to structurally unrelated antigens and its relationship to histocompatibility antigens in guinea-pigs. | Five strains of guinea-pigs homozygous for GPL-A and 2/13 histocompatibility antigens were sequentially immunized with seven structurally unrelated antigens (TGAL, BPO-BGG, ASAN, BPO-PLL, phenetidine, horseradish peroxidase and DNP-dodecapeptide). Considerable differences in the immune response were observed, as measur... | 47,308 | [
0.6105852,
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0.1842835,
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0.3882141,
0.2306785,
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Release of extracellular enzymes from Bacillus amyloliquefaciens. | Washed-cell suspensions of Bacillus amyloliquefaciens secrete significant amounts of the extracellular enzymes alpha-amylase and protease for about 15 min in the almost complete absence of protein synthesis. This apparently represents release of preformed enzyme en route to secretion. The release was independent of ene... | 47,325 | [
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0.02790934,
0.02756142,
0.00796652,
0.6542459,
0.04854821,
-0.282082... |
Orcein staining of hepatitis B antigen in paraffin sections of liver biopsies. | Liver biopsies from 97 hepatitis B antigen (HBsAG)-positive patients were stained by a modified orcein method described by Shikata et al (1974) in order to detect the antigen in liver tissue. The results were consitently negative in acute hepatitis, but positive in nearly two-thirds of biopsies from 53 patients with ch... | 47,336 | [
0.1338624,
0.08021693,
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0.2638956,
0.09511319,
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0.2... |
Competition for antigen by cell populations having receptors with the same specificity but of different idiotype. | All normal A/J mice immunized with keyhole limpet hemocyanin-p-azophenylarsonate (KLH-Ar) produce anti-Ar antiboides, some of which share a cross-reactive idiotype. The present results indicate that the biosynthesis of antibody molecules bearing this idiotype does not occur in mice having an excess of lymphoid cells wi... | 47,356 | [
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0.008424463,
0.1123553,
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0.566327,
0.04407654,
-0.02436716... |
In vitro response of mouse spleen cells to the solid phase immunogen DNP-O-Bio-Gel. | The in virto immunogenicity of the solid-phase hapten, dinitrophenyl-ornithine-Bio-Gel (DNP-O-Bio-Gel), was investigated in cultures of mouse spleen cells. Appropriate combinations of cells and immobilized hapten were determined. Large numbers of direct anti-hapten plaque-forming cells (PFC) were generated when 1 times... | 47,361 | [
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0.2965157,
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0.1152339,
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0.2445013,
0.007130819,
... |
Neglected coeliac disease. | A review has been carried out of patients diagnosed as having coeliac disease some years previously and subsequently lost to follow-up. Most were unaware of the need for continuing treatment and had returned to a normal diet. The resulting morbidity was slight, although one patient had died of a small-bowel lymphoma. I... | 47,419 | [
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0.01379757,
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0.02332506,
-0.0207829,... |
Needle biopsy for muscle chemistry. | Needle biopsy can readily provide samples of human skeletal muscle for biochemical analysis. Muscle metabolites are measured by enzymic microanalytical techniques and electrolytes by neutron-activation analysis. This paper summarises the methods of analysis, gives the normal ranges for muscle contents of metabolites an... | 47,494 | [
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0.2260269,
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... |
Association of foot lesions with retinopathy in patients with newly diagnosed diabetes. | A proportion of newly diagnosed diabetic patients have features so characteristic that they form a distinct syndrome. The patients are predominantly male and present with a foot lesion which is often long established. They are subsequently found to have diabetes mellitus and diabetic retinopathy. In addition, many of t... | 47,532 | [
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0.359201,
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0.1377257,
0.04336636,
0.3023086,
0.0088271... |
Physiological mechanisms for cardiac control by nutritional intake after early maternal separation in the young rat. | Series of analytic experiments are presented that explore possible physiological mechanisms for the control of cardiac rate by nutritional intake in the pre-weanling rat. The essential properties of the nutrient and the first site of action were studied by using fluids of different pH, osmolality and chemical compositi... | 47,639 | [
0.1292329,
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0.03859513,
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0.3124534,
0.1318416,... |
[Orthorhythmic pacemaker and salvo-like cardiac stimulation. New procedure aiming at the suppression and prophylaxis of cardiac arrhythmia and the determination of electrophysiological measurement magnitudes in vivo]. | The orthorhythmic pacemaker (ORPM) represents a new apprach in cardiac stimulation. The use of conventional demand pacemakers is essentially limited to the treatment of bradycardic arrhythmias. The principle of the ORPM consists in early stimulation after premature beats, taking into account the R-R interval of the pre... | 47,644 | [
-0.4140394,
0.09424432,
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0.2291199,
-0.05403279,
-0.1976664,
0.1511753,
0.002442515,
0.116534... |
Recent results in the surgical treatment of Fallot's tetralogy. | Tetralogy of Fallot consists essentially of two abnormalities: a large, unrestrictive ventricular septal defect and severe obstruction to the outflow of the right ventricle. A clear understanding of the principles described in this article should result in a mortality of under 5% after complete correction of tetralogy ... | 47,651 | [
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0.2596447,
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-0.07187886,
0.1802542,
0.4337454,
-0.0917056... |
Soluble proteins of bronchopulmonary secretions from patients with cystic fibrosis, asthma, and bronchitis. | The concentrations of nine plasma proteins were determined by quantitative immunoelectrophoresis in sputum specimens from 29 patients with cystic fibrosis (CF) and from 24 patients with severe asthma and chronic bronchitis. The results suggested that the population of CF patients could be divided into two groups in spi... | 47,656 | [
0.09058467,
0.02497946,
0.0002110092,
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0.008053144,
0.09281918,
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0.1845212,
-0.010... |
[Reproduction of leukovirus RD-114 in diploid and heteroploid human cells]. | The capacity of leukovirus RD-114 to replicate in human embryo lung diploid cell cultures and continuous human angiosarcoma cell cultures (AS and 709 lines). Differences in the capacity to support the virus reproduction were observed in the two strains of human embryo lung cells (HEL-1 and HEL-3) and the two continuous... | 47,667 | [
-0.3202759,
0.08637443,
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0.02195978,
0.281536,
0.3034397,
-0.0915473,
... |
Characterization of spermatozoal auto-, iso- and allo-antigens. | Three approaches are utilized to study and characterize spermatozoal antigens. An immunological approach has demonstrated the presence of spermatozoal auto-, iso- and allo-antigens. Spermatozoal auto-antigens studies by several authors are able to induce the whole spectrum of immune reactions (delayed hypersensitivity,... | 47,684 | [
0.05663489,
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0.1286702,
0.2254277,
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0.3410926,
0.1525719,
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0.... |
HL-A, fertility and natural selection. | The antibodies occasionally produced in gravid females usually cause no adverse effects and the mother may become hyporesponsive. Exceptions may occur in some cases of abortion where frequency of antibodies appears to be unduly high. Sperm antigens in the mouse include T locus alleles as well as H-2 and H-Y. The T locu... | 47,686 | [
0.06923345,
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0.1864247,
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0.156238,
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0.313973,
0.3539664,
-0.2770383,
0.... |
Acute viral hepatitis: factors possibly predicting chronic liver disease. | A number of clinical, biochemical, immunological and morphological variables were recorded at first admission of 500 consecutive patients with biopsy verified acute viral hepatitis in the period February 1969-June 1972. In February 1973, 28 of these patients had a morphologically documented chronic liver disease: 4 cir... | 47,692 | [
-0.02427256,
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0.4026847,
0.4333796,
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... |
Nucleolar size in benign and malignant plasma cell proliferation;. | Nucleolar and nuclear size of bone marrow plasma cells has been studied in 26 cases of myeloma, 19 of benign essential monoclonal gammapathy (BEMG) and 9 without an M-component. Bone marrow smears were Feulgen-stained to visualize nucleoli and nuclei. Nucleolar area, nuclear area and the ratio nucleolar area/nuclear ar... | 47,698 | [
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0.130032,
0.1339894,
0.1238238,
0.6368973,
0.1049857,
0.1468131,
... |
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