title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Reactions of fluorescent probes with normal and chemically modified myelin basic protein and proteolipid. Comparisons with myelin. | Basic (encephalitogenic) protein and water-soluble proteolipid apoprotein isolated from bovine brain myelin bind 8-anilino-1-naphthalenesulfonate and 2-p-toluidinylnaphthalene-6-sulfonate with resulting enhancement of dye fluorescence and a blue-shift of the emission spectrum. The dyes had a higher affinity and quantum... | 50,085 | [
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Plasma proteins and immunoglobulins in penguins (Pygoscelis adeliae). | Total and fractionated proteins were evaluated in the serum of normal penguins. Four proteins with antibody activity, determined by passive haemagglutination, were isolated by Sephadex G-200 filtration and DEAE-cellulose chromatography, from the serum of penguins (Pygoscelis adeliae) inoculated with dinitrophenylated h... | 50,086 | [
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The monoclonal nature of lymphatic leukemia. | Monoclonal membrane-bound Ig were found by immunofluorescence on the lymphocytes in the vast majority of cases of chronic lymphocytic leukemia. The distribution of H and L chains among these patients reflected the distribution of surface Ig on normal lymphocytes and IgM was the predominant class. The importance of the ... | 50,095 | [
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Imbalances of IgG subclasses and gene defects in patients with primary hypogammaglobulinemia. | The chance mating of persons with structural or regulator gene abnormalities might be expected to result in individuals who lack the capacity to synthesize specific types of heavy chains and manifest as hypogammaglobulinemia. Disproportionate levels of IgG subclasses would then be expected since the heavy chains are sy... | 50,100 | [
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Tumour imaging radiopharmaceuticals. | 32P, 131I-labeleed human serum albumin, 75Se-seleno-methionine, 107Hg-chlormerodrin, 67Ga-citrate and labelled bleomycin compounds, among others are discussed with particular respect to their observed clinical characteristics and suggested mechanisms of uptake. It is shown that there are striking similarities in the ki... | 50,109 | [
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Modification of radiation injury to normal tissues by chemotherapeutic agents. | The effects of several cancer chemotherapeutic agents on radiation damage to normal intestine, esophagus, and lung tissue were evaluated in LAF 1 mice using quantitative endpoints. In all tissues tested, actinomycin D increased injury and BCNU did not. In the intestine, adriamycin enhanced radiation damage more than an... | 50,122 | [
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Reversible ultrastructural changes of arcuate neurons after vinblastine injection into the median eminence of the rat. | The ultrastructural effects of vinblastine on the arcuate neurons and median eminence were studied in the rat. The animals were stereotaxically injected with solutions of 1 mM and 5 mM vinblastine into the median eminence and killed 3, 8 and 21 days after injection. Eight days after injection of 1 mM vinblastine the ... | 50,135 | [
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Concealed ventricular extrasystoles due to interference and due to exit block. | Two cases of sinus rhythm with ventricular extrasystoles are reported in which extrasystoles arising from the same focus obey the rule of "comcealed bigeminy" and the "rule of bigeminy". In a comparatively rapid sinus rhythm, shortening of the sinus cycle favors the appearance of extrasystoles, and the extrasystoles ob... | 50,154 | [
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Sleep physiology at high altitude. | All night sleep EEG, EKG, and respiration were recorded from six young men during 2 nights at sea level and 4 nonconsecutive nights at high altitude (14.110 ft., 4301 m). Sleep at high altitude was chraacterized initially by a significant decrease in Stages 3 and 4, a significant increase in the number of arousals, and... | 50,171 | [
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Auditory evoked potentials during sleep in normal children from ten days to three years of age. | Auditory evoked potentials (AEPs) to clicks of moderate intensity were studied in 130 normal sleeping children from 10 days to 3 years of age. Latencies of the principal response components were found to decrease with log age, i.e., change was most rapid during the first year of life. From 15 days of age to 3 years, me... | 50,197 | [
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Single unit activity in basal ganglia of monkeys during performance of a delayed response task. | Single unit activity was recorded from the basal ganglia (caudate, putamen and globus pallidus) of monkeys during the performance of a delayed-response task. The task was divided into five epochs: stimulus onset, delay, pre-response, post-response and reqard. A high percentage of units recorded from the basal ganglia w... | 50,201 | [
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A simplified circuit for stimulus artifact suppression. | This note describes a simple electronic method of eliminating time-locked stimulus artifacts from recordings of cerebral evoked potentials. The hardware required for a 16-channel battery-powered suppressor system costs less than $80. The complete circuit can be fabricated from readily available components on a single 6... | 50,203 | [
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Oculomotor outflow and its relation to electrical activity of suprasylvian gyrus and pulvinar during paradoxical sleep in the cat. | During paradoxical sleep, single unit activity was recorded from the posterior part of the middle suprasylvian cortex together with the electrical activity of the medial rectus eye muscles and that of the pulvinar nucleus. Experiments were performed on unrestrained cats, which slept in a dark cage. The intervals betwee... | 50,205 | [
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The clinical significance of occipital spikes as a sole response to intermittent photic stimulation. | Forty-five patients who showed occipital spikes as a sole response to IPS have been studied over a 9 year period. Occipital spikes induced by IPS are non-specific, not constantly present and in themselves are not indicative of epilepsy. Occipital spikes alone are seen in a very small percentage of clinical photosensiti... | 50,206 | [
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Electroencephalographic signs of ethanol tolerance and physical dependence in the cat. | Spontaneous electrical activity was recorded from three cortical and five subcortical sites, via permanently implanted electrodes, in five conscious, freely-moving adult cats. Initial observations were made during and after an intravenous infusion of ethanol, 1 g/kg. The animals then received ethanol by gastric intubat... | 50,212 | [
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[Rhythmic slow waves and multi-unit activity during sleep-waking cycle in the rat ventral tegmentum]. | 1. Multi-unit activity (MUA) was recorded together with gross activity in different structures during various states of sleep in 43 rats. The records were made by means of telemetry from lateral hypothalamus, nucleus ruber, formatio reticularis, dorsal hippocampus and the ventral mesencephalic tegmentum (VMT) surroundi... | 50,215 | [
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Modification of the direct cortical response by taurine. | The effects of taurine on the direct cortical response have been studied in immobilized cats (with local analgesia). The primary negative component of the response was inverted in polarity by the topical application of 25 mM taurine while the later slow negative component was considerably augmented. These effects are i... | 50,228 | [
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Interactions of antiepileptic drugs. | Several interactions involving antiepileptic drugs are based on changes in the rate of their metabolism and elimination, with concomitant rise or fall of plasma levels. Thus, phenobarbital generally induces the production of the DPH metabolizing enzyme, but its presence inhibits the action of that enzyme. The net resul... | 50,232 | [
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Standardization of allergens by an improved skin-testing technique. | From the seemingly most appropriate methods for standardization procedures of allergen extracts, the most serious candidates are in sequence of age: the old atopic skin test, the histamine-release test, using human basophil cells and the radio-allergosorbent test. At the moment it is not yet certain which method gives ... | 50,244 | [
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Biochemical and cytogenetic studies on the nucleolus organizing regions (NOR) of man. II. A family with the 15/21 translocation. | The amount of ribosomal DNA (rDNA) was determined quantitatively by RNA-DNA hybridization in the genomes of a mother and her daughter, both with the karyotype 45,XX,t(15q21q). The saturation values found were 0.030% (mother), 0.023% (daughter), and 0.022% for the husband and father of the daughter. A detailed cytogenet... | 50,266 | [
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The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects. | The distribution of X-ray induced aberrations between trypsin-banded regions within human chromosomes has been studied in over a thousand cells from normal and abnormal individuals. An analysis of this data has been performed for each type of aberration separately, taking into account the relative amount of material at... | 50,279 | [
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Influence of interferon on the synthesis of virus particles in oncornavirus carrier cell lines. III. Survey of effects on A-, B- and C-type oncornaviruses. | The effect of interferon on the synthesis and release of A-, B- and C-type viruses by oncornavirus carrier lines was studied. Murine cell lines were selected which carry either of these viruses and are sensitive to the antiviral effect of interferon, as measured by inhibition of vesicular stomatitis virus. Release of C... | 50,292 | [
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Comparison of intracytoplasmic A particles and intracisternal A particles. | Intracytoplasmic A particles and intracisternal A particles are associated with mouse tumors of various types, and both can coexist in the cytoplasm of the same cell. The designation of both as A particles is based on the recognition that they share morphological similarities. A comparison of purified isolates of these... | 50,295 | [
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Storage granules of thyroid C cells in the dog: a cytochemical and ultrastructural study, in relation to the masked metachromasia reaction. | Masked metachromasia can be demonstrated in thyroid C cells, and other cells of the APUD series, by staining with a metachromatic basic dye after hydrolysis of suitably fixed tissue. The reaction is thought to be due to the presence of polypeptides with a high concentration of side-chain acidic groups. Since most APUD ... | 50,304 | [
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Aminoglycoside 3'-phosphotransferases I and II in Pseudomonas aeruginosa. | Aminoglycoside 3'-phosphotransferases I and II in three strains of Pseudomonas aeruginosa were studied in comparison with those in two strains of R factor-carrying Escherichia coli. The strain TI-13 of P. aeruginosa produced the former and strain H-9 the latter. Strain B-13 produced the both enzymes. The 3'-phosphotran... | 50,310 | [
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Further studies on telestability in DNA. The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20). | The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20) are described. Thermal denaturation studies on these DNAs in the absence and presence of actinomycin, which binds only to the GC portions of these molecules, have confirmed and extended our previous observati... | 50,322 | [
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Mutual modification of glucose-stimulated serum insulin responses in female rhesus monkeys by ethinyl estradiol and nortestosterone derivatives. | Changes in iv glucose tolerance (IVGTT) and serum insulin responses to glucose infusion have been measured in intact female rhesus monkeys treated per os with norethindrone or medroxyprogesterone acetate (500 mug/day) both alone and in combination with mestranol or ethinyl estradiol (10 mug/day) orally for 3 weeks. Whe... | 50,326 | [
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Demonstration of a tumor-associated surface antigen in Marek's disease. | Surface antigenic markers were detected on three classes of Marek's disease (MD) tumor cells, i.e., MD lymphoma cells, cultured cells of the MSB-1 lymphoblastoid cell line, and JMV lymphoblastic leukemia cells, by indirect membrane immunofluorescent staining with serum from chickens immunized with JMV cells or from rab... | 50,345 | [
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Antigenicity of carcinogen and viral induced sarcomas in inbred and random bred guinea pigs. | A tumor specific transplantation antigen (TSTA) has been detected in a methylcholanthrene (MCA) induced guinea pig tumor. It was possible to induce resistance to rechallenge with the tumor by immunization with irradiated cells in CFA. In contrast, the same technique failed to detect TSTA in two viral (Kirsten strain mo... | 50,348 | [
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Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization. | Addition of high molecular weight dextran to culture medium prevents the initiation of T lymphocyte-mediated killing by holding the cytolytic T lymphocytes (CTL) and target cells in suspension and preventing intercellular contact. Suspension in 10% dextran was used to interrupt the ongoing formation of adhesions betwee... | 50,350 | [
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Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs. | The resistance of Strain 2 guinea pigs to experimental allergic encephalomyelitis (EAE) induced by inoculation with whole CNS tissue in complete Freund's adjuvant (CFA) has been confirmed. The resistance is even more pronounced when myelin basic protein (BP) is used in attempts to induce EAE. Strain 2 guinea pigs are a... | 50,359 | [
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Class, amounts and affinities of anti-dinitrophenyl antibodies in chickens. I. Production of 7S and 17S antibodies of equal affinity by intravenous injection of antigen. | Repeated intravenous injections of maximally coupled dinitrophenylated bovine gamma-globulin elicited both 7S and 17S anti-dinitrophenyl antibodies in chickens. Only antibodies of low affinity were produced regardless of the priming dose, the interval between injections, and the number of injections. The 7S and 17S ant... | 50,371 | [
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Immunologic effects of morphine administration in rabbits. | Long-term effects of morphine administration or immunologic test responses were studied in female rabbits. Implantation of morphine-containing pellets was found to be more effective than injection of morphine sulfate solutions in promoting increased serum binding of 140-morphine. A large part of the increased morphine ... | 50,375 | [
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Isolation of hepatitis B surface antigen (HBsAg) by affinity chromatography on antibody-coated immunoadsorbents. | Hepatitis tb surface antigen (HBsAg) was isolated from human serum by two steps of affinity chromatography on antibody-coated gels. HBsAg-positive serum was passed through a column packed with guinea pig anti-HBsAg antibodies covalently bound to CNBr-activated beaded agarose gel. The majority of non-specifically bound ... | 50,379 | [
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Determination of antibody avidity at the cellular level by the plaque inhibition technique: effect of valence of the inhibitor. | Inhibition of plaque formation by multivalent and univalent ligands was compared as an assay of avidity of antibody produced by PFC. Multivalent ligands are much more effective as inhibitors and their use tends to impart an appearance of lack of heterogeneity and high avidity to the PFC populations being studied. It is... | 50,381 | [
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Microfilaments in the external surface layer of the early amphibian embryo. | A comparison was made by transmission electron microscopy of the microfilaments in the surface layers of the early embryos of Triturus alpestris and Xenopus laevis at stages of development up to neurulation. Actin-like filaments which bound heavy meromyosin (HMM) were found in cell extracts of all stages, but were comp... | 50,397 | [
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Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis. | Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the... | 50,401 | [
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[Long-term treatment with L-DOPA in a case of torsion dystonia (authors transl)]. | A 36-year old woman had been able to move from place to place only by crawling until 1971 after she had been treated with L-DOPA, the dose of which was increased to a maximum of 2.5 g daily. Within 4 weeks there was a diminution of her increased muscle tone and she experienced a dramatic improvement in her daily living... | 50,417 | [
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On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis. | The effect of phospholipase A1 of human brain on 1,2-diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1 or 2 position, was determined in subacute sclerosing panencephalitis. An increase of approximately 40% in the specific activity of phosp... | 50,420 | [
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[A case of Guillain-Barré syndrome following cholera vaccination (author's transl)]. | A 45-year-old woman developed bilateral ascending flaccid paralysis after cholera vaccination, 15 days after the first and 1 day after the second injection. The clinical course resulted in nearly complete paralysis of the lower limbs, paresis of the upper limbs and partial involvement of the cranial nerves. There was o... | 50,424 | [
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Inhibition of granulation tissue growth by histamine. | Granulomas were induced in rats by subcutaneous implantation of formalin-soaked filter-paper disks. Daily subcutaneous injection of histamine at doses of two times 0.05 mg/kg and above inhibited the growth of granulation tissue as measured by a marked decrease in the dry-defatted granuloma weight and of the hydroxyprol... | 50,437 | [
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The skin-reactive antigens of Mycoplasma pneumoniae. | Guinea pigs experimentally infected with Mycoplasma pneumoniae or immunized with the orgnaism in combination with Freund's complete adjuvant developed a delayed hypersensitive skin reaction following on intradermal injection of the M. pneumoniae antigen. The amount of protein necessary to produce the delayed skin react... | 50,469 | [
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[The so-called inoperable rectal carcinoma. Simultaneously, a contribution to the prognosis of rectal carcinoma]. | Rectal cancer is quite easy to identify. Simple methods of investigations and early symptoms should allow a good prognosis. This is patholphysiologically supported by slow increasement and relatively late filialisation along long metastatic roads. Therefore it is to be regretted, that of 632 patients, suffering from re... | 50,554 | [
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The peripheral odontogenic fibroma. | An extensive review of the English-language literature has produced only five undoubted cases of peripheral odontogenic fibroma. This article reports ten new cases. The age and sex of the patients and the distribution by site and histology of the lesions are compared with those of other cases of bifrous tumors and neop... | 50,585 | [
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Posttranslational protein modifications, with special attention to collagen and elastin. | It is apparent that significant progress has been made in our understanding of the biosynthesis, modifications, and maturation of collagen and elastin. We now recognize and partially understand special reactions involved in hydroxylations within the cell and complex cross-linking processes occurring outside the cell. R... | 50,603 | [
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Secretory and structural changes in the parotid salivary gland of sheep and lambs after parasympathetic denervation. | The effect of the parasympathetic nerve supply on the development of the parotid gland in the immature lamb and its maintenance in the adult sheep has been investigated by unilateral postganglionic denervation. Seventy-seven to ninety-three days after denervation secretory activity of the gland was examined and materia... | 50,604 | [
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[Determination of urinary total proteins and some protein fractions]. | In unconcentrated specimens measurements have been made of total proteins, by DOETSCH gel-filtration method, and of albumin, transferrin and of alpha-2-macroglobulin, by LAURELL electroimmunodiffusion technique. The results confirm that the gel-filtration method provides specific, reliable measurement of proteins in am... | 50,609 | [
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Third HL-A segregant series: genetic analysis and molecular independence on lymphocyte surface. | Five sera which detect two alleles of the third HL-A locus (T2 and T4) are described. Statistical analysis of a panel of 220 donors gave gene frequencies in a French Parisian population which are comparable to the results of Scandinavian authors. Segregation observed in 50 families emphasized the linkage disequilibriu... | 50,634 | [
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Direct cell mediated lympholysis. A test of allograft-rejection in human kidney recipients. | In kidney transplanted patients a clear coincidence was observed between clinical signs of allograft rejection and the presence in the peripheral blood of killer cells able to lyse either PHA lymphoblasts from the actual donor or selected unrelated individuals. In recipients with non-immunological complications such as... | 50,635 | [
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An analysis of the 4c complex of HL-A based on Indian populations. | Sera detecting part or all of the 4c group of HL-A antigenic specificities were compared in two American Indian populations, the Ixils and the Pimas, and in one Spanish-Indian hybrid population, the Mestizos of Peru. Several new variants appeared. These were not identical to HL-A5, W5 or W18. Two of the variants appear... | 50,643 | [
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An inclusion analysis for studying HL-A specificities. | INCLAN (Inclusion analysis) is a computer program which provides a systematic search for the subtypic variants of a given serological specificity. This routine was found especially useful for the HL-A serology whose complexity often needs automatic displays. A detailed description of its structure is presented in this ... | 50,645 | [
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Donor HL-A incompatibility and lymphocytotoxic antibody response in human renal allotransplantation. | When 81 recipients of primary renal allografts were examined for the influence of donor HL-A incompatibilities (DIC) on the survival of allografts, an association was found between greater DIC and not only an increased loss of allografts in the 1st year, but also a decreased survival of transplants in the subsequent ye... | 50,657 | [
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[Morphology of the clinical stage O of the prostatic carcinoma (incidental carcinoma) (author's transl)]. | 141 prostatic carcinomas of the clinical stage O (incidental carcinoma) have been analyzed morphologically. The tumors were highly differentiated carcinomas in 41.8% of the cases as compared to only 11.8% in the whole material of 989 carcinomas of all clinical stages in our prostatic carcinoma registry. In 42 cases (29... | 50,661 | [
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[Effect of gamma globulin on reactivity of the organism. V. Types of biological activity of gamma globulin preparations]. | Biological activity of 110 series of commercial gamma-globulin preparations was studied; they were found to contain placental antigens, group-specific blood substances, gonadotropic hormones and antibodies to them. Placental antigens were found in 12% of placental and abortive gamma-globulin batches in titres of 1 : 2-... | 50,682 | [
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Gastrointestinal investigations in dermatitis herpetiformis. | Thirty-seven patients with dermatitis herpetiformis (DH) have been investigated for gastric and small intestinal abnormalities. Evidence of an enteropathy was found in 86% of the patients who had IgA deposits in uninvolved skin. Villous atrophy of the small intestine was found in 29 patients. About one-half of the pati... | 50,693 | [
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0.00854254,
0.1655171,
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0.04699174,
0.3329934,
0.1450136,
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... |
Warty dyskeratoma. | A case is reported of a 53-year-old woman, who had had for one year a wart-like papillomatus lesion on the alveolar process in the region corresponding to m The remaining mucosa exhibited a normal clinical picture. The patient's general health was satisfactory and no skin manifestations of interest were apparent. The l... | 50,698 | [
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Incontinentia pigmenti achromians (Ito). | A case of incontinentia pigmenti achromians syndrome with associated abnormalities occurring in a 21-year-old woman is reported. Since birth she has had whorling macular, hypopigmented areas on the skin of the lateral, anterior, and posterior aspects of the trunk. Histopathological picture: the melanocytes in the depig... | 50,700 | [
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[The biomechanics of hyaline cartilage under distension stress]. | The mechanical properties of costal cartilage specimens from cattle were tested under periodical compressive loads. The specimens were put between the compression plates of an electronic materials testing machine and were exposed to defined deformations and deformation rates. On the basis of these induced periodical de... | 50,705 | [
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... |
Experimental rheumatoid arthritis-like features induced by prolonged sensitization with focal antigens. | Prolonged sensitization with emulsion of an autologous or isologous subcutaneous abscess of Arthus type induced by injection of hen egg-white was performed in 34 rabbits which were divided into (high responder and intermediate responder groups (H- and M-groups) according to individual difference of immune responses. Th... | 50,712 | [
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Alcoholic hyalin-like bodies found in the pancreatic acinar cells and nerve cells of the brain. | The presence of hyalinoid body as an eosinophilic, dendriform to irregularly shaped mass was noted in the cytoplasm of pancreatic acinar cells of 13 among a series of approximately 150 autopsy cases of alcoholism examined. Similar subcellular structures were also demonstrable in nerve cells of the brain in 2 of these ... | 50,713 | [
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Effect of long-term administration of different hard liquors and red wine on the rat liver. A histological and biochemical study. | Male rats were given 50 per cent of calories as ethanol, whisky, brandy, gin and red wine for 8-9 months together with moderate or low protein and vitamin supply. Histological studies at sacrifice failed to detect signs of hepatotoxicity, but biochemical studies indicated that at least red wine and whisky produced more... | 50,714 | [
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The ultrastructure of cultivable treponemes. | Cells of Treponema genitalis were studied in the electron microscope by means of negative staining and ultrathin sectioning techniques. All cells were covered by a regularly structured surface layer. This layer appeared to consist of pairs of thin fibrils attached to an amorphous layer. This amorphous layer in turn is ... | 50,715 | [
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Effects of adenosine-5'-triphosphate (ATP) on rat mast cells: influence on anaphylactic and compound 48/80-induced histamine release. | Anaphylactic histamine release from mast cells isolated from actively sensitized rats was inhibited by pre-incubation with micromolar concentrations of ATP. The inhibition was reversible under various experimental conditions and was counteracted by the presence of calcium in the incubation medium. Histamine release ind... | 50,722 | [
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Light dependence of osmium reactivity in mouse photoreceptor cells. | Mouse photoreceptor cells exhibit local accumulations of osmium deposits after prolonged osmic staining at slightly elevated temperatures. Deposits were evident along the membranes of outer segment lamellae, Golgi cisternae and vesicles, nuclear envelopes, and synaptic vesicles. Other membranes within the photoreceptor... | 50,727 | [
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... |
The detection of hepatitis B antigen in hepatic parenchyma by the fluorescent antibody technic. | Tissue sections from 42 specimens of liver were examined by indirect immunofluorescence microscopy for the presence of hepatitis B antigen (HB Ag). In all cases the serologic status of HB Ag was known. Fourteen of the specimens were also examined by electron microscopy. In four biopsies from three patients positive cyt... | 50,731 | [
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0.2974237,
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Isolation of arboviruses (Kemerovo group, Sakhalin group) from Ixodes uriae collected at Macquarie Island, Southern ocean. | Eighty-nine pools of ticks (Ixodes [Ceratixodes] uriae White) collected at Macquarie Island (54 degrees 30' S, 159 degrees E) in the Southern Ocean yielded 16 strains of 2 viruses, 1 a "new" member of the Kemerovo group and 1 a "new" member of the Sakhalin group. The names "Nugget" and "Taggert" are proposed for them. ... | 50,749 | [
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[Bacterial cytostimulation by specific antibodies (author's transl)]. | Antibodies bound to the surface of Escherichia coli cells stimulate the rate of growth of these bacteria in proportion to their quantity. This "cytostimulation" of the bacteria is confirmed by (1) the increase in optical density, (2) colony counts and (3) increase in the beta-galactosidase activity of a constitutive st... | 50,758 | [
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0.09454995,
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[Isolation and characterization of a high molecular weight placental protein (PPg)(author's transl)]. | The isolation and characterization of a high molecular weight protein (PP6) from human placentae is described. The protein which apparently has some steroid-binding properties shows the mobility of an alpha1-globulin and has a molecular weight of around 1 X 10(6) daltons. The molecule is composed of several different s... | 50,830 | [
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0.3403552,
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0.140067,
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Bony metastases from carcinoma of cervix. Occurrence, diagnosis, and treatment. | Fifty-five patients treated for cervical carcinoma developed bony metastases between January 1, 1961 and December 31, 1973. Roentgenograms were diagnostic in all but 2 of the patients. In 15 patients, a combination of radioactive scans and roentgenograms was used to establish the diagnosis. The most common mechanism of... | 50,873 | [
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0.3992846,
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In vitro biochemical and cytotoxicity studies with 1-beta-D-arabinofuranosylcytosine and 5-azacytidine in combination. | The effect of 1-beta-D-arabinofuranosylcytosine (ara-C) and 5-azacytidine (5-aza-C), alone and in combination, on DNA synthesis and cytotoxicity in hamster fibrosarcoma cells has been studied. After a 2-hr exposure of S-phase cells to ara-C at concentrations of 2 to 200 muM, the cells required about 4 to 6 hr to recove... | 50,882 | [
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[Presence of the H blood group antigen on a carcinoembryonic antigen (CEA). Enzymatic transformation of H to A and B specificities]. | The carcinoembryonic antigen (CEA-M) was purified from a hepatic metastasis obtained from a blood group O patient with a cancer of the rectum. Using 125I-labelled-CEA and blood group antisera, H specificity was found on the CEA-M; the addition of anti-H to anti-CEA does not modify the binding of labelled-CEA-M to its a... | 50,886 | [
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0... |
The etiology of osteosarcoma. A review of current considerations. | Various agents have caused osteosarcoma in several experimental animal systems. These agents or initiators may be classified as chemicals, radiation, viruses, and miscellaneous. Zinc beryllium silicate with beryllium oxide in rabbits and FBJ virus in mice are two such initiating agents. The relevance of these animal ex... | 50,894 | [
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Synthesis, structure and function of avian sarcoma virus-specific DNA in permissive and nonpermissive cells. | We have reviewed our recent evidence for the following scheme for synthesis and integration of viral DAN after infection of permissive cells by ASV: Within the first 3 hours of infection, duplex, virus-specific DNA the length of a subunit of the viral genome (3 times 10(6) daltons) is synthesized in the cytoplasm of in... | 50,903 | [
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FSH stimulation of testicular androgen binding protein (ABP): comparison of ABP response and ovarian augmentation. | Production of testicular androgen binding protein (ABP), ceases following hypophysectomy and can be stimulated by FSH. Within 24 h after the administration of FSH, ABP can be measured in caput epididymis supernatant and by 4 days after FSH treatment, the concentration of ABP reaches a plateau. In a 3-day assay, ABP pro... | 50,922 | [
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Noble metals: a toxicological appraisal of potential new environmental contaminants. | The public health benefits expected by reducing known hazardous emissions from mobile sources should not be compromised by increasing levels of other potentially hazardous unregulated emissions. Catalytic converters are going to be used to meet the statutory requirements on carbon monoxide and hydrocarbon emissions fro... | 50,939 | [
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0.3110059,
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... |
An objective measurement of nonspeaking children's performance with a computer-controlled program for the stimulation of language behavior. | A method is described for recording a child's performance with a computer-controlled audio-visual device designed to stimulate language behavior in nonspeaking children. From the recorded data a child's position can be estimated on a curve derived from normal children. This position could be of value in planning treatm... | 51,018 | [
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0.08614387,
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Proteinase C (carboxypeptidase Y) mutant of yeast. | A mutant of yeast lacking proteinase C (carboxypeptidase Y) activity has been found by using a histochemical stain to screen mutagenized colonies. This defect segregates 2:2 in meiotic tetrads. Cell extracts lacked the esterolytic, amidase, and proteolytic activities associated with proteinase C. The absence of protein... | 51,020 | [
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0.2996326,
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0.02400... |
Experimental exophthalmos. Binding of thyrotropin and an exophthalmogenic factor derived from thyrotropin to retro-orbital tissue plasma membranes. | Biologically active preparations of 125I-thyrotropin, [3H]thyrotropin, and the [3H]exophthalmogenic factor derived from thyrotropin by partial pepsin digestion have been used to study the binding properties of the thyrotropin receptor on guinea pig retro-orbital tissue plasma membranes. In regard to the optimal conditi... | 51,021 | [
-0.03795342,
-0.5021123,
-0.4532436,
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0.09966872,
0.3448933,
0.2866087,
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... |
Hyperthyroidism in Tasmania following iodide supplementation: measurements of thyroid-stimulating autoantibodies and thyrotropin. | Serum thyroid-stimulating autoantibodies (LATS and LATS protector) and thyrotropin (TSH) concentrations were measured in the serum of 30 patients with hyperthyroidism living in Tasmania who developed their disease following correction of iodine deficiency by addition of iodate to the bread. Patients were grouped accord... | 51,028 | [
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0.3336115,
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0.4... |
Cellular immune response to peripheral nerve basic protein in idiopathic facial paralysis (Bell's palsy). | Lymphocytes from patients with Bell's palsy were shown to undergo significant stimulation when cultured in vitro in the presence of a purely neuritogenic basic protein (P1L) isolated from human peripheral nerve myelin. No sensitization was observed to other neural antigens, namely, another periperal nerve myelin basic ... | 51,046 | [
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0.04981247,
0.1070547,
0.05004042,
... |
Racial predilection in multiple sclerosis. | Comparisons between the geographic distribution of multiple sclerosis and the habitats of various racial groups showed that racial factors alone could not explain the increase in prevalence of the disease with latitude. Racially similar groups living in different areas had different frequencies of multiple sclerosis. C... | 51,065 | [
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... |
[X-ray studies of the brain as a basis for stereotaxy (author's transl)]. | All attempts to reconstruct the topography of the brain in the living from studies of animal material are handicapped by technical difficulties. The best method is to compare exact X-ray pictures, which have been taken under stereotactic conditions. From a large collection of such X-rays the authors have composed conto... | 51,075 | [
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0.103762,
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0.2196587,
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-0.... |
An alcian blue-phloxine method for the gross demonstration of squamous metaplasia in the larynx. | A macroscopic method using the dyes Alcian blue and phloxine is described for the investigation of squamous metaplasia in the larynx. The method also demonstrates an intermediate type epithelium about which little is known. The gross staining of the tissues is based upon the differential penetration of the dyes through... | 51,082 | [
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0.3891751,
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0.1425917,
0.2521229,
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0.07030414,
0.2333702,
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0.526585,
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0.175641,... |
Ultrastructure of the invasion of Eimeria magna sporozoites into cultured cells. | Monolayers of bovine kidney cells were overlaid with Eimeria magna sporozoites and observed with phase-contrast optics until penetration of the cells by the parasites had begun. Cells and penetrating parasites were fixed with glutaraldehyde and OsO4-containing ruthenium red, dehydrated, and embedded in situ. Cells be... | 51,083 | [
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0.1882972,
0.381056,
0.2667128,
... |
Detection of a TL(+) murine leukemia cell line that resists the cytotoxic effects of guinea pig complement and specific antiserum. | RADA-1 cells [H-2a thy-1b; thymus-leukemia (TL) 1, 2, 3], a radiation-induced murine leukemia cell line maintained by serial transfer in histocompatible recipients, resisted lysis by guinea pig complement (GPC) and TL 1, 3; TL 2; or TL 1, 2, 3 antiserum. The cells expressed TL antigenic specificities as determined by i... | 51,085 | [
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0.4042755,
0.5593171,
0.07707331,
-0.086798... |
Cell-mediated and humoral immunity in mice: cross reaction between lysozyme and S-carboxymethylated lysozyme studied by a modified footpad test. | The mouse sensitized by subcutaneous (sc) injection of lysozyme in emulsion of Freund's complete adjuvant (FCA) was shown by a modified footpad test to develop three kinds of hypersensitivities. Injecting lysozyme in 2.5-mul emulsion of Freund's incomplete adjuvant (FIA) into the footpad elicited strong footpad swellin... | 51,109 | [
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0.05217542,
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0.3993521,
0.03228897,
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Surgery of the thyroid. | The sophistication of current surgical treatment of thyroid disorders reflects a better understanding of the pathophysiology. The development of more methods of therapy with antithyroid drugs, beta-adrenergic blocking agents, thyroid hormones, and radioactive isotopes as well as external irradiation has had an importan... | 51,140 | [
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0.1657854,
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0.03655928,
0.2749132,
0.3295448,
-0.306158... |
Maternal effects of regular salicylate ingestion in pregnancy. | 6.6% of all Australian patients attending an antenatal clinic were found to be taking salicylate preparations regularly, most commonly in powder form and almost always as self-medication. In this group of salicylate takers there was an increased incidence of anaemia, anti-partum and post-partum haemorrhage, prolonged g... | 51,142 | [
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0.0338898,
0.5250839,
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... |
Fetal effects of regular salicylate ingestion in pregnancy. | The babies of 144 mothers who took salicylates regularly in pregnancy are described. These babies had a significantly reduced birth-weight compared with controls; many of them had a raised cord-blood salicylate level but had no clinical evidence of bleeding or hypoglycaemia. Their perinatal mortality was increased, but... | 51,143 | [
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0.1082209,
0.03438383,
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0.2501674,
-0.1296076,... |
Micrococcal urinary-tract infections in young women. | In a prospective study in young women, novobiocin-resistant subgroup-3 micrococci were the second commonest cause, after Escherichia coli; of acute urinary infections. Proteus mirabilis was the only other causative organism. Symptoms, pyuria, or possible aetiological factors were the same in micrococcal and coliform in... | 51,404 | [
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0.4351496,
0.4107857,
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... |
Biodegradation of alpha-hexachlorocyclohexane. IV. The extent of degradation of single doses in vivo. | 1. Urine and stools were collected daily of 4 adult rats kept in single cages and injected once i.p. with alpha-hexachlorocyclohexane (alpha-HCH; dose per animal 126-150 mumoles), labelled uniformly with 14-C (10.8-14.0 X 10(6) dpm per animal). 2. In 4 weeks, 65% of the label was excreted through the kidneys and 16% by... | 51,480 | [
-0.3186686,
0.08066711,
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0.2807779,
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0.3321576,
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0.03530843,
0.31843,
0.5389445,
-0.02791155,
0.4733389,
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0.... |
Alpha globulin intracytoplasmic hepatocyte globules in round heart disease in turkeys, visualized by immunofluorescent technique. | The intracytoplasmic hepatocyte globules described in round heart disease of turkeys were found by immunofluorescent technique to contain alpha globulins. The diagnostic value of this method is discussed. | 51,495 | [
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0.05522132,
0.3477747,
0.1452818,
0.089774... |
Inhibition of 4,alpha-dimethyl-m-tyramine (H 77/77)-induced hypermotility in rats by single and repeated administration of chloropromazine, haloperidol, clozapine and thioridazine. | The effect of H 77/77 (5 mg/kg s.c.) on motility of rats kept in a familiar cage was investigated. H 77/77 produced hypermotility, which was reduced by oral pretreatment with chlorpromazine, haloperidol, clozapine and thioridazine. The 4 neuroleptics were administered acutely and for a 14 day period. H 77/77 was given ... | 51,502 | [
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0.128608,
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0.1140205,
0.08912056,
0.07408199,
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0.06896411,
0.1447282,
... |
The reflex sympathetic dystrophy syndrome. A comprehensive analysis using fine-detail radiography, photon absorptiometry, and bone and joint scintigraphy. | Nine patients with reflex sympathetic dystrophy were examined. Clinical manifestations suggesting arthropathy were supported by radiographic demonstration of juxta-articular and subchondral bone erosions and by radionuclide demonstration of increased activity localized in the joint regions. Aggressive demineralization ... | 51,504 | [
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0.123039,
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0.03788076,
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... |
[Myelin sheath staining (author's transl)]. | In Loyez-Woelcke's myelin sheath staining the author studied the effect of the tanning time, that of the ripening grade of hematoxylin as well as the effect of the staining time. In case of a determined staining time a certain proportion must be present between the ripening grade (or the quantity of the oxidizing agen... | 51,548 | [
0.2038935,
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0.1248318,
0.108622,
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0.0472864,
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0.1462206,
0.7063918,
0.2191337,
-0.1048649,
0.1... |
[Sensitization against the antigens of the brain after experimental vaccinia infection. I. Evidence for cell-mediated immune response to brain-antigens (author's transl)]. | Vaccinia virus infection was performed by scarification of the shaved skin (5 times 5 cm2) on the back of Pirbright guinea pigs. The macrophage migration inhibition test was performed with peritonealexudate cells 7, 11, 14 and 21 days after infection. Macrophage migration inhibition occurred after exposure of the cells... | 51,549 | [
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0.135281,
0.03358827,
0.4966009,
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0.2745625,
-0.1887026... |
Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma. | A series of 191 patients with bronchial asthma were treated with menaquinone for not less than one year to investigate the clinical effects of the drug. The clinical effect may be summarized as follows: 1) The therapy with menaquinone only gave an effective rate oo 90.9% (a markedly effective rate of 42.4%) in mild pat... | 51,576 | [
0.07471865,
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0.009457633,
-0.163187,
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0.1164715,
0.0009962338,
0.23384,
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0.1045526,
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0.08957784,
0.4986241,
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0.1645969,
0.22835,
0.1001644,
-0.07633876,
0.0631... |
Salivary secretion in three species of tsetse flies (Glossinidae). | The study of the mechanism and process of salivation in tsetse flies is of paramount importance towards a fuller understanding of the transmission of trypanosomiasis and nagana diseases. Gordon, Crewe and Willett (1956) made direct observations, through a microscope, of the haustellum of G. morsitans as it penetrated i... | 51,581 | [
0.06714424,
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0.2150184,
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0.04128594,
0.14841,
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0.134473,
0.04517167,
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0... |
Perivascular and intervascular reticular fibers of the retina. | We demonstrated the existence in the retina of an argyrophilic perivascular membrane comparable in all respects to that which exists throughout the vascular system. We compared our findings by light microscopy with those previously reported. We identified, by electron microscopy, the normal general location of the netw... | 51,589 | [
-0.06936511,
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0.06829318,
0.1985155,
0.2276195,
... |
Preparation of monospecific antiserums against porcine immunoglobulins, using agarose-linked immunosorbents. | Immunoglobulins IgG, IgA, and IgM were isolated from porcine serum and milk, and antiserums against the 3 immunoglobulin classes were prepared. Monospecificity of the antiserums for the gamma-, alpha-, and mu-chains was obtained by absorbing them in agarose-linked immunosorbent columns. These immunosorbents were prepar... | 51,601 | [
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0.1282836,
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0.3857536,
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-0.3686838,
-... |
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