title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Studies on the prevalence of type C virus associated with gibbon hematopoietic neoplasms. | Gibbon malignancy frequently involves the hematopoietic system and can occur in clusters. Virus isolated from gibbon neoplasms possessed typical type C virus morphology, and the virion measured 100 nm in diameter with an electron-dense nucleoid measuring approximately 75 nm. The virus incorporated 3H-uridine into the n... | 51,628 | [
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Detection and characterization of RNA tumor virus-specific DNA in cells. | RNA tumor virus-specific DNA in cells can be detected by its capacity to 1) alter the reassociation kinetics of labeled double-stranded product of viral RNA-directed DNA polymerase; 2) anneal single-stranded DNA (cDNA) synthesized by viral polymerase; or 3) hybridize labeled viral 70S (genomic) RNA. Duplexes formed wit... | 51,630 | [
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Further studies on the antigenic properties and distribution of the putative bovine leukemia virus. | The C-type viruses found in long-term cultures. New Bolton Center (NBC) cell lines, of peripheral lymphocytes from leukemic cattle and in short-term cultures of bovine buffy coat(BC) cells share an immunofluorescent(IF)antigen detected in the cytoplasm of infected cells as well as an antigen demonstrable in gel diffusi... | 51,637 | [
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Analysis of inhibition of lymphocyte cytotoxicity in human colon carcinoma. | Serum inhibition of autochthonous lymphocyte cytotoxicity for tumour cells has been studied in 112 cases of colonic carcinoma. Addition of patient's serum to the lymphocyte tumour cell reaction mixture resulted in decreased cytotoxic reactivity of lymphocytes from 8 of 39 cytotoxic positive cases. It was also shown tha... | 51,647 | [
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Enzymatic modification of the transplant antigens (ABO system) on human tumor cells. | Blood group glycosyltransferases were used to modify HeLa cells of H specificity (O Group) into cells of A and B specificity. We also obtained the identical type of modification with lymphocytes from healthy subjects and leukemia patients. This method can be applied to tumor cells in general, and constitutes an attempt... | 51,681 | [
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A comparison of aldehyde fuchsin and alcian blue staining of neurosecretory material in Oncopeltus fasciatus. | The dynamics of the "A" cells of the parsintercerebralis of Oncopeltus fasciatus over the first eight days of adult life was studied by microspectrophotometry of sections stained either with aldehyde fuchsin or alcian blue 8 GX. The data show that the two stains differ in their selectivity as they record different even... | 51,687 | [
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[Scanning transmission electron microscopy of dendritic spines stained by the Golgi method]. | Scanning transmission electron microscopy of the dendritic spines of multipolar neurons in the cat inferior Colliculus was achieved on Golgi semi-thin sections. The three basic types of dendritic spines (ST, MS, TH) were identified. Scanning transmission electron microscopy provides a reliable method for a three dimens... | 51,692 | [
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[Metabolism and in vitro binding of several organochlorine and organophosphate pesticides to calf thymus DNA and rat liver microsomal proteins]. | The organophosphorus insecticide ethyl-parathion was transformed by rat liver microsomes into metabolites which were bound to calf thymus DNA, in large amount. When the rats were treated by phenobarbital or 3-methylcholanthrene, the metabolite binding to DNA was increased two-fold. By contrast, in the same conditions, ... | 51,693 | [
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Immunochemical studies of organ and tumor lipids XXI. Sensitivity and specificity of the cytolipin F - sheep erythrocyte system. | The sensitivity and specificity of the sheep erythrocyte - anti-sheep erythrocyte system to inhibition by pure cytolipin F has been studied with 5 antisera, in order to compare it with the rat erythrocyte-anti-rat lymphosarcoma system and its inhibition by pure cytolipin R. The cytolipin F - sheep erythrocyte system is... | 51,702 | [
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Visual cortex responses to abrupt changes in the periodicity of rapidly intermittent light. | Visually evoked potentials that are stimulated by period-jumps in a high-frequency modulated luminance have been detected and studied experimentally in monkeys. The visual responses are shown quantitatively by a Principal Components analysis to depend remarkably simply, in shape and in amplitude, on the period-jump sti... | 51,713 | [
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Mouse immunoglobulin genes: studies on the reiteration frequency of light-chain genes by hybridisation procedures. | The partially purified immunoglobulin light chain messenger RNA fraction from P3K (MOPC 21) mouse myeloma tissue-culture cells has been employed in hybridisation studies. Fragments of the messenger RNA were generated by alkali hydrolysis. 6-S fragments not containing poly(A) showed the characteristic biphasic hybridisa... | 51,793 | [
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Mechanism of action of rifamazine, a member of a new class of (dimeric) rifamycins. | 1. Rifamazine (AF/RP) a dimeric rifamycin, is active against bacterial DNA-dependent RNA polymerase and against viral RNA-dependent DNA polymerase. 2. Rifamazine is active also against DNA-dependent RNA polymerase extracted from rifampicin-resistant mutants of Escherichia coli. It does not interfere with enzyme-templat... | 51,795 | [
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Protein polymorphism in the Hanuman langur (Presbytis entellus). | 26 specimens of Presbytis entellus were examined for a variety of blood proteins. In contrast to previous studies of other species of leaf monkeys, our P.entellus sample proved to be very heterogeneous. Polymorphisms were found in the third component of complement, group-specific component, glycine-rich beta-glycoprote... | 51,813 | [
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Relative DNA content of human euchromatin and heterochromatin after G, C and Giemsa 11 banding. | Human chromosomes and interphase nuclei labeled with 3H-thymidine and treated with the ASG and trypsin technique for G banding show no DNA loss. However, after G 11 and C banding significantly more DNA is removed from euchromatin than from constitutive heterochromatin. | 51,823 | [
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Identification of interspecific translocation chromosomes in human-Chinese hamster hybrid cells. | Chromosome material of human and Chinese hamster origin can be stained differentially in human-Chinese hamster translocation chromosomes by use of the Giemsa-11 staining technique. | 51,825 | [
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The thyrotropin-stimulation test in patients with solitary hot nodules of the thyroid gland. | Thyrotropin (TSH)-stimulation tests were performed on 21 patients with solitary hot nodules in the thyroid gland. Twelve of the patients were euthyroid and nine were hyperthyroid. The average age of the euthyroid patients was 38 +/- 14 (SD) years, and that of the hyperthyroid patients, 55 +/- 8 years. Prior to TSH stim... | 51,842 | [
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The establishment of a venereal disease clinic: II. An appraisal of current diagnostic methods in uncomplicated urogenital and rectal gonorrhea. | Some of the diagnostic procedures for uncomplicated urogenital and rectal gonorrhea were studied in a university-based venereal disease clinic. On the basic of our results, recommendations are made concerning the types of media to be used, sites to be sampled, methods of obtaining specimens, and other diagnostic consid... | 51,845 | [
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How to make the diagnosis of rectal gonorrhea in men. | A simple quick method of diagnosing male rectal gonorrhea, applicable to office practice, is described using conventional staining techniques and microscopy. Photomicrographs of clinical smears serve as a guide line to practitioners. Neigon Jembec plates proved superior to Transgrow media for the culturing of isolates ... | 51,846 | [
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The contribution of phosphorylation and loss of COOH-terminal arginine to the microheterogeneity of myelin basic protein. | Two guinea pig myelin basic protein preparations which differed markedly in their contents of high pH electrophoretic or chromatographic forms were studied in an attempt to elucidate the causes of their microheterogeneity. Both total preparations and components isolated therefrom were examined for their amino acid comp... | 51,849 | [
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Histamine release from human leukocytes: modulation by cadmium ion. | The effect of cadmium on histamine release was studied in relation to the role of calcium. The antigenic histamine release from peripheral leukocytes of ragweed-sensitive patients was inhibitied in the presence of cadmium (greater than 10(-5) M). Spontaneous histamine release was not affected by cadmium except for an e... | 51,863 | [
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A contribution to immunological specificity of DNA in leukosis. | Active antisera containing antibodies to deproteinized DNA preparations of normal tissue and the spleen of cows suffering from myeloleukosis were obtained. The anti DNA sera to DNA preparations contained complement fixing antibodies related to gamma M globulins. In the study of leukosis and normal anti DNA sera in quan... | 51,870 | [
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The xenogeneic effect. I. Antigen and mitogen-stimulated human lymphocytes produce a non-antigen-specific factor which reconstitutes the antibody response of T cell-deficient mouse spleen cells. | Modified Marbrook culture vessels with two chambers separated by a 0.2-mu porosity membrane have been utilized to show that antigen-stimulated human lymphocytes produce a soluble factor(s) which restores the ability of thymectomized, irradiated, and bone marrow-protected mice to mount a primary IgM plaque-forming cell ... | 51,888 | [
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Studies on the induction and expression of T cell-mediated immunity. IV. Non-overlapping populations of alloimmune cytotoxic lymphocytes with specificity for tumor-associated antigens and transplantation antigens. | Two non-overlapping populations of alloimmune cytotoxic T cells with specificity for tumor-associated antigens (TAA) and for histocompatibility antigens (H-2) were characterized by two independent methods. The heterogeneity of cytotoxic cells was demonstrated in spleen cells derived from BALB/c (H-2d) mice sensitized t... | 51,889 | [
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Variants of N-tropic leukemia virus derived from BALB/c mice. | Clonal lines derived from cultures of NIH/3T3 cells infected with N-tropic leukemia virus from BALB/c mice differ in the amount and type of N-tropic virus they produce. Three biologically distinguishable N-tropic viruses were found: the large XC plaque-forming virus of hartley et al. (1969) (LP-N), A SMALL XC plaque-fo... | 51,938 | [
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An outbreak of hepatitis associated with intravenous injection of factor-VIII concentrate. | An outbreak of jaundice associated with three out of four batches of a commercial brand of freeze-dried factor-VIII concentrate occurred at the Bournemouth haemophilia centre between April and June, 1974. Seven cases of non-B hepatitis and four of hepatitis B occurred within 6 months of the first use of this product. T... | 51,975 | [
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Relevance of "significant bacteriuria" to aetiology and diagnosis of urinary-tract infection. | 28 of 74 female domiciliary patients who presented with urinary-tract symptoms did not fulfil the usually accepted laboratory criterion required for confirmation of urinary-tract infection (i.e., a urinary bacterial viable count in excess of 100 000/ml). The progress of the disease was similar in non-bacteriuric and ba... | 52,006 | [
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Trial of digoxin in mania. | A suggestion that mania is associated with an increased membrane transport of sodium has been investigated in a double-blind trial of a specific Na-K A.T.P.ase inhibitor (digoxin) in twelve female inpatients with mania. Digoxin had no effect. | 52,007 | [
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Simultaneous investigation and treatment of suspected acute adrenal insufficiency. | The increase in plasma-fluorogenic-corticosteroids in response to a single injection of tetracosactrin depot was measured in eleven patients with suspected acute renal insufficiency who were treated simultaneously with prednisolone and deoxycorticosterone acetate (D.O.C.A.). Acute adrenal insufficiency was excluded in ... | 52,051 | [
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0.3290455,
0.3113569,
0.2672609,
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... |
Quantitative separation of antigen-specific murine antibodies by anti-allotype chromatography. | The use of Sepharose-conjugated murine anti-Iga or anti-Igb allo-antisera allowed the quantitative separation of immunoglobulins of the two allotypes. After fractionation of mixtures of anti-(T,G)-A--L antisera obtained from congenic strains differing in immunoglobulin allotype, it was possible to measure the antigen-b... | 52,179 | [
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Antibody-dependent cell-mediated cytotoxicity: heterogeneity of effector cells in human peripheral blood. | We have compared antibody-dependent cell-mediated cytotoxicity (ADCMC) of human peripheral blood leukocytes (PBL) in three model systems. target cells were 51Cr-labeled mouse mastocytoma cells, chicken erythrocytes (CRBC), and human erythrocytes (HRBC) coated with appropriate heterologous or isologous antisera. Effecto... | 52,180 | [
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[Renaut's bodies and familial neuropathy of the Dejerine-Sottas type. Apropos of 2 anatomo-clinical cases]. | The authors report the pathological and clinical findings in two cases of familial Dejerine-Sottas neuropathy, including the peripheral nerve lesions of an unusual type producing extensive sub-perineural separation. In one case, there was onion bulb hypertrophy of the schwann layer and definite demyelinisation and abov... | 52,195 | [
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[The effect of health educational measures on the state of oral hygiene. 1. Relationship between intensity and effectiveness]. | The effectiveness of health educational measures increases with the time spent for them. A health education which motivates the patients towards personal activity is unequivocally superior to passive forms of health education such as information, instruction and demonstration. | 52,209 | [
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[Kanner's syndrome and childhood schizophrenia]. | The examination of 32 children with Kanner's syndrome of early infantile autism permits to assume that this syndrome in some of the cases is expressed only by inborn anomalies which correspond to constitutional psychopathy in adults. In most of the cases this syndrome forms the initial expression of child schizophrenia... | 52,249 | [
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Surgical treatment of paronychia granulomatosa hallucis. | Paronychia granulomatosa is a complication incident to unguis incarnatus; surgery for this complaint was performed on 26 patients with 52 granulomas. The operation was first described by Bartlett in 1937. The postoperative hospitalization was 3 days and the patients returned a week later to have the sutures removed. Af... | 52,265 | [
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... |
In vitro and in vivo release of histamine by contrast media in the rat. | Some contrast media are able to release histamine from isolated mast cells of the rat and produce degranulation of these cells. Such properties are fairly correlated with the ability to increase vascular permeability in vivo and to produce a drop in blood pressure. If histamine is similarly being released in humans man... | 52,284 | [
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0.1472... |
Tricuspid atresia: clinical course in 101 patients. | The clinical profile and course of 101 patients with tricuspid atresia seen at the Children's Hospital Medical Center, Boston, were reviewed; the electrocardiograms, hemodynamic data, associated anomalies, complications of the malformation and surgical results were outlined and a definition of anatomic types and radiol... | 52,296 | [
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Quantitative immunoelectrophoresis of proteins in human erythrocyte membranes. Analysis of protein bands obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. | 1. We have defined conditions that permit quantitative immunoelectrophoresis in agarose gels of dodecyl sulfate-solubilized erythrocyte membrane proteins. 2. Using human serum albumin, transferrin, MN-glycoprotein (glycophorin) and crude spectrin as test proteins, we found that accurate analyses are possible if samples... | 52,375 | [
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[Evaluation of cytochemical methods of studying the localization of alkaline phosphatase in B. subtilis]. | A study was made of a possibility of using the "lead" and the "calcium" methods for the determination of localization of alkaline phosphatase in the bacterial cells. Cytochemical medium containing lead nitrate could not be used for determination of the true localization of the alkaline phosphatase in the microorganisms... | 52,378 | [
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0.... |
Demonstration of two molecular variants of carcinoembryonic antigen by concanavalin A sepharose affinity chromatography. | The carcinoembryonic antigen (CEA) active glycoproteins from perchloric acid extract of liver-metastasized primary colon tumor have been separated by concanavalin A Sepharose (Con A Sepharose) chromatography. The CEA activities separated by Con A Sepharose chromatography were designated as loosely bound and tightly bou... | 52,402 | [
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... |
Arrhythmia prophylaxis: Long-term suppressive medication. | The author describes the notions that led to initiation of controlled trials of long-term medication with antiarrhythmic drugs following myocardial infarction, and reviews reports of controlled trials with diphenylhydantoin, alprenolol, and procaine amide. It is concluded that, so far as possible widespread prophylacti... | 52,418 | [
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Application of the patient-self (P-S) test to assess the specificity of hyposensitization with Allpyral-G. | Following hyposensitization with Allpyral-G5-grass mix the level of blocking antibody is assessed against the 5-grass mix, against Timothy (one of the grasses) and against Meadow Grass (not included in the five grasses) respectively and the results compared. The implications are that only very limited protection is giv... | 52,419 | [
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... |
Electroencephalographic correlates of myoclonus. | In order to overcome various drawbacks of the conventional polygraphic study of a relationship between myoclonus and EEG, the EEG preceding and following the myoclonic jerk was simultaneously averaged by the CNV program. The subjects were 7 patients presenting with myoclonus of various kinds. The conventional polygraph... | 52,438 | [
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Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization. | The effects of high frequency electrical stimulation of both diffusely projecting brain regions and regions of more restricted projection were studied on penicillin-induced cortical epileptiform focal activity in the cat. Results obtained were contingent on the level of focal activity present at the time of stimulation... | 52,443 | [
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EEG responses to photic stimulation in persons experienced at meditation. | The EEG responses to intermittent photic stimulation were examined in a group of subjects experienced in meditation, and compared with those of a control group. The meditators exhibited a significantly smaller decrement in alpha activity and alpha blocking over the course of the experiment than did the control group, a... | 52,446 | [
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The click-evoked post-auricular myogenic response in normal subjects. | The presence of the posterior auricular myogenic reflex was infectigated in healthy subjects. Click stimuli were delivered alternately to each ear and both ipsilateral and contralateral responses were recorded simultaneously. Smiling and head down position increased the number of responses. With this method, in contras... | 52,447 | [
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0.1348626... |
Isolation of parietal cells from guinea-pig gastric mucosa and the immunological characterization of their antigenic structure. | A method is described for the isolation of parietal cells from the gastric mucosa of the guinea pig by enzymatic digestion with collagenase. A suspension was obtained that contained 70-80% parietal cells. About 80% of the cells were viable immediately after incubation, but viability dropped sharply after one hour. Pari... | 52,572 | [
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... |
[Studies on the osmotic resistance and the viability of amidinated erythrocytes]. | The present studies are concerned with properties of amidinated erythrocytes. The reactions of dimethyladipimidate with proteins in solution and red blood cells, respectively, result in an intermolecular cross-linking. Following an amidination of human serum albumin or human gamma-globulin cross-linked products of incr... | 52,577 | [
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... |
[Morphological characteristics and pattern of hepatitis B antigen expression in liver tissue in acute and chronic forms of hepatitis (author's transl)]. | Immunofluorescent and electron microscopic methods allow the localization of hepatitis virus B-components at the cytologic and histologic level. The acute and chronic forms of viral hepatitis are re-evaluated in the light of these new findings. In HB-Ag-positive hepatitis four types of correlation between the expressio... | 52,591 | [
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Microphotometry of rat liver nucleoproteins during the cell cycle, and comparison of diploid nuclei in the G2 period with tetraploid nuclei. | The following facts were established with a microphotometric investigation of isolated nuclei from rat liver in different stages of the cell cycle. During the mitotic wave occurring in the liver of newborn animals after injection of casein it was found that the naphtol yellow S (NYS) protein content of the nuclei incre... | 52,641 | [
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Pre - proparathyroid hormone identified by cell - free translation of messenger RNA from hyperplastic human parathyroid tissue. | An 8-15S fraction of RNA isolated from hyperplastic human parathyroid tissue (primary chief-cell hyperplasia) and translated in a cell-free extract of wheat germ directs the synthesis of a protein that shares antigenic determinants and tryptic peptides with parathyroid hormone and its previously recognized immediated p... | 52,656 | [
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The effect of alloantisera on antigen-induced T cell proliferation. | In the guinea pig, alloantisera raised by cross-immunization of strain 2 and strain 13 animals are capable of specifically inhibiting the in vitro proliferative response of (2 X 13)F1 T lymphocytes to those antigens the response to which is controlled by Ir genes linked to the genes controlling the alloantigens against... | 52,669 | [
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... |
Histamine release from human leukocytes: relationships between cyclic nucleotide, calcium, and antigen concentrations. | The antigen-induced IgE-mediated release of histamine from human basophils has previously been shown to require calcium, to be inhibited by agents which raise cyclic AMP levels and by high antigen levels, and to be unaffected by cyclic GMP. The interrelationship between these phenomena has been studied. The major findi... | 52,671 | [
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Hepatitis B antibody in conventional gamma-globulin. | Recent lots of conventional gamma-globulin prepared from the plasma of outdated blood collected from voluntary donors in Massachusetts contain substantially more antibody (anti-HBs) to the hepatitis B surface antigen (HBs Ag) than do lots manufactured from plasma collected before 1970. Variations in titer of anti-HBs m... | 52,682 | [
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... |
Bifunctional major histocompatibility-linked genetic regulation of cell-mediated lympholysis to trinitrophenyl-modified autologous lymphocytes. | Murine thymus-derived lymphocytes can be sensitized in vitro to trinitrophenyl (TNP)-modified autologous spleen cells (1, 2). Cytotoxic effector cells were generated which were specific for TNP-modified target cells expressing the same H-2K and H-2D serological regions as the modified stimulator cells (3, 7). Spleen ce... | 52,685 | [
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[Indications for stereotaxic neurosurgery of patients with multiple sclerosis (author's transl)]. | The long-term results of 12 stereotaxic operations on 11 multiple sclerosis patients with incapacitating intention tremor were evaluated and compared with the experiences of other authors. The selection of the patients, the criteria applied for the success and the length of the follow-up period influenced the reported ... | 52,694 | [
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... |
[Orbicularis oculi reflexes and evoked response of orbicularis oris muscle in Bell's palsy. A prognostic study (author's transl)]. | In 84 patients with idiopathic, clinically complete Bell's palsy the electrically induced blink reflexes with their two components (OOR I and II) were electromyographically recorded on both sides using skin electrodes. In 67 of these patients the evoked responses of the orbicularis oris muscle were also studied. The la... | 52,696 | [
0.1044833,
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0.08219852,
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0.12196,
0.1609923,
0.02585389,
0.5601922,
-0.1236837,
-0.2128974,
0.009... |
Preliminary investigations of intrinsic and extrinsic optical activity as purity criterion for human serum albumins. | Induced circular dichroism measurements were made to follow the binding of four acidic drugs to two lots of crystalline and two lots of fraction V human serum albumins. The magnitude of the induced circular dichroism varied with all lots of albumin, suggesting a strong sensitivity of the phenomenon to small changes in ... | 52,705 | [
-0.2167766,
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Isolation of an endogenous C-type RNA virus from Mus musculus molossinus. | We isolated a type-C RNA virus from the Japanese field mouse, Mus musculus molossinus. M. musculus musculus and M. musculus molossinus are two different subspecies of Mus and thus only distantly related. The virus grew only on cells foreign to the host, was xenotropic, and readily rescued the murine sarcoma (MuSV) geno... | 52,716 | [
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Host range studies of FLOPC-1 murine myeloma C particles. | The host range of the C particle produced by FLOPC-1 myeloma cells, FLOPC-1 murine myeloma-associated virus (FL-MuMAV), was assessed in terms of its ability to productively infect and/or induce new viral antigens in a variety of different cell lines. Production of C particle-like structures by cells exposed to FL-MuMAV... | 52,724 | [
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... |
Symptomatic care of patients with amyotrophic lateral sclerosis. | Until a definitive treatment is found for amyotrophic lateral sclerosis, there will continue to be a need to provide symptomatic care. Experience with caring for a large number of patients has proved that symptomatic therapy can be based on rational principles. Treatment should be limited to procedures that are simple ... | 52,730 | [
0.02903374,
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... |
A new type of familial hypercholesterolaemia. | Two members of a family (proband and daughter) with hypercholesterolaemia have an abnormal low-density lipoprotein which fails to suppress the activity of a rate-determining enzyme for cholesterol biosynthesis (3-hydroxy-3-methyl glutaryl-CoA reductase) in leucocytes of the patients and controls. However, the proband's... | 52,771 | [
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0.2262671,
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Isolation of "speckled" nuclear antigen reactive with autoantibodies in patients with cancer and autoimmune diseases. | An antigenic substance reactive with autoantibodies found in patients with cancer and autoimmune diseases was isolated from calf thymus. The purification procedure included extraction of the tissues with acetone powder, batch and column chromatography on DEAE-resins, ammonium sulfate precipitation, gel filtration on Se... | 52,888 | [
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Plastic sectioning for light microscopy of Pyrenomycetes. | In preparation for light microscopy, ascocarps of Sordaria fimicola Ces. & DeNot. were embedded in Spurr's medium and sectioned at 1-1.5 mum on an ultramicrotome. Sections were floated on Giemsa staining solution at 60 C for 10-30 min, washed in distilled water, affixed to slides by drying, and mounted in immersion... | 52,918 | [
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0.2410746,
0.1344925,
-0.0903... |
Thin layer chromatography of certain preformed metal complex dyes used in biological staining. | Thin-layer chromatographic systems are described for the analysis of various performed metal complex dyes (aluminon-chromium (III), carminic acid-aluminum, carminic acid-chromium (III), carminic acid-iron (III), celestine blue-chromium (III), gallamine blue-chromium (III), gallocyanin-chromium (III), hematein-aluminum,... | 52,919 | [
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0.0641894,
0.7208921,
0.05448146,
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... |
Urinary excretion of 5-S-cysteinyldopa in patients with primary melanoma or melanoma metastasis. | Urinary excretion of 5-S-cysteinyldopa was studied in 9 patients with primary melanoma. All had 5-S-cysteinyldopa excretion in the normal range. In 8 of the patients excretion values decreased after removal of the tumour. Twenty-four patients with clinical signs of melanoma metastasis were examined for 5-S-cysteinyldop... | 52,967 | [
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... |
Treatment of psoriasis with oral psoralens and longwave ultraviolet light. Therapeutic results and cytogenetic hazards. | The purpose of the present investigation was to study the usefulness of oral treatment of psoriasis with psoralens and longwave ultraviolet light and the possible cytogenetic hazards of this therapy. 8-methoxypsoralen (8-MOP) in doses between 15 and 60 mg orally followed 2 hours later by UVA irradiation of one side of ... | 52,973 | [
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0.3084999,
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... |
Light and electron microscopic studies of the pulmonary alveolar surfactant. | 22 methods of light and electron microscopy have been tested for the identification of the pulmonary alveolar surfactant. Among the non electron microscopic methods Romhányi's anisotropic staining with toluidine blue was the most serviceable. In addition to simple performance it allows the identification of the smalles... | 52,986 | [
0.2665828,
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0.2580903,
0.09496896,... |
Influence of carbonates and other salts in tissues on the Schiff's reagent. | Application of the Schiff's reagent on fresh and undecalcified cuticle of crustaceans such as Emerita asiatica and Ocypoda platytarsis showed positive results with their calcified layer which led to suggest that salts of calcium account for the staining. In vitro studies with carbonate and other salts furnished confirm... | 52,990 | [
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0.06076178,
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... |
The influence of genotype on the development of glomerular lesions in mink with Aleutian disease virus. | In an attempt to document progression rate differences in the development of glomerular lesions in mink infected with Aleutian disease virus (ADV), the glomeruli of Aleutian and non-Aleutian mink experimentally infected with ADV were evaluated by light, fluorescent, and electron microscopy. The animals were also examin... | 53,016 | [
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Cytochemical localization of catalase activity in methanol-grown Hansenula polymorpha. | The localization of peroxidase activity in methanol-grown cells of the yeast Hansenula polymorphia has been studied by a method based on cytochemical staining with diaminobenzidine (DAB). The oxidation product of DAB occurred in microbodies, which characteristically develop growth on or methanol, and in the intracrista... | 53,039 | [
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0.4234689,
0.2837527,
0... |
Palliation of tricuspid atresia. Potts-Smith, Glenn, and Blalock-Taussig shunts. | Aortopulmonary (Potts-Smith), subclavian-pulmonary (Blalock-Taussig), and cavopulmonary (Glenn) shunts are the commonly performed operations for palliation of tricuspid atresia. A total of 104 patients with tricuspid atresia have undergone these procedures, either alone or in combination over a 28-year-period at the Ho... | 53,043 | [
0.02585088,
0.2473089,
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0.3788346,
0.2138551,
... |
[Disodiumcromoglycate and histamine liberation by cotton dust extract in the rat (author's transl)]. | 1. Disodiumcromoglycate (DSCG) had no influence on the microscopical appearance of rat peritoneal mast cells either by i.p. injection (2 times 10(-5) g/ml) or by i.v. infection (10 mg/kg) nor by local application (2 times 10(-5)/1 times 10(-4) g/ml). 2. A particular effect of DSCG (2 times 10(-6)/2 times 10(-5) on the ... | 53,054 | [
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0.3727987,
0.4762335,
0.02879901,
0.5032516,
-0.001100... |
A new assay for the measurement of total progressive antithrombin. | A new rapid method for assaying total antithrombin activity has been developed based on the inactivation of thrombin incorporated into an agarose gel, during the radial diffusion of plasma in the gel. The area of thrombin inactivation is subsequently observed by the coagulation of fibrinogen in a separate agarose gel l... | 53,064 | [
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0.2203981,
0.4841942,
0.1308898,
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The oxyphil and C cells of the human thyroid gland. A cytochemical and histopathologic review. | The C and oxyphil cells of the human thyroid are analyzed in the light of recent advances in cellular biology, cytochemistry, and histopathology. The C cell is present in the normal human thyroid, where its identification is cardinally by means of argyrophilic cytoplasmic granules. The morphology, topography and argyro... | 53,094 | [
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0.1017895,
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Nutrition and experimental carcinogenesis: a review. | Restriction of the total diet or the number of calories fed to rats and mice inhibits the formation of tumors in several tissues. Unless animals are fed equivalent levels of food, or attain equivalent body weights, it is difficult to assess the significance of the effect of other nutritional modifications on carcinogen... | 53,097 | [
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... |
Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretroy system of the rat. | Immuno-enzyme histochemical investigations showed that, in the magnocellular hypothalamo-hypophysial neurosecretory system of the rat, vasopressin and oxytocin are synthetized in separate neurons. Both the vasopressin neurons and the oxytocin neurons are present in both the supraoptic and the paraventricular nuclei in ... | 53,102 | [
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[Histopathological picture of acute disseminated intravascular coagulation]. | The paper deals with histological analysis of 72 cases characterized by the finding of capillary microthromboses characteristic of acute disseminated intravascular coagulation (DIC). It has been stressed that, in addition to the usual fibrillary fibrin deposits, DIC is also characterized by the occurrence of globular f... | 53,107 | [
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0.03696001,
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[Immunologic comparison between some Wolbachiae and research of antigentic community with other members of the order of Rickettsiales]. | The antigenic relationship between some rickettsiae of arthropods, which do not transmit germs pathogenic to vertebrates was investigated by agglutination and immunofluorescence techniques. The comparison of R. melolonthae, R. tipulae, R. cetonidarum, R. grylli and of the rickettsiae of the scorpion Buthus occitanus sh... | 53,109 | [
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0.145337,
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0.1411293,
0.2100744,
0.1789818,
0.1960616,
-0.287079,
-0.00... |
Simple differential Giemsa staining of sister chromatids after treatment with photosensitive dyes and exposure to light and the mechanism of staining. | The essential steps of the 33258 Hoechst-Giemsa method for differential chromatid staining consist of (1) 33258 Hoechst treatment, (2) exposure to light, and (3) Giemsa staining. The staining was shown to be a function of the concentration of 33258 Hoechst and the light exposure. The dye was successfully replaced by va... | 53,133 | [
0.1039717,
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0.06206684,
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0.2152287,
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Sleep-waking cycle in rabbits after cerebral ischemia. | In rabbits experimental cerebral ischemia of 4-6 min was followed by degradation of the electroencephalographic sleep-waking cycle, as determined from 3 h afternoon records: I. Hyposomnia i.e., reduction of slow wave and paradoxical sleep lasting for about 2 days, was seen, with gradual normalization in case of surviva... | 53,146 | [
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0.06606934,
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0.1484801,
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[Investigations on the influence of Rh immunoglobulin prophylaxis on the immune response to postpartum rubella vaccination (author's transl)]. | A preliminary investigation showed that patients with rubella HHT antibody titres of 1:8 or greater did not show a significant rise in the antibody titre following rubella vaccination. The rubella antibody titre was determined in 651 obstetric patients. Of these, 43 (6.6%) had no significant antibodies to rubella (HHT ... | 53,168 | [
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0.2239572,
0.5743194,
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-0.1592588,... |
[Differential diagnosis of congenital lipidoses by lipid analyses of body fluids, biopsy and autopsy tissue]. | 1. Presentation of the commomly used procedures for the extraction and separation of total lipids, glycolipids and phosholipids from fresh and formalin-fixed organs tissues (brain, liver, spleen, kidney) as well as from serum, CSF and urine. II. Description of the qualitative and quantitative analysis of individual lip... | 53,174 | [
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0.3577531,
0.2891102,
0.4871066,
-0.11933... |
Oxidase (donor: oxygen oxidoreductase) activity by peroxidase and alpha2-macroglobulin interaction. | The interaction between peroxidase (donor: hydrogenperoxide oxidoreductase, EC 1.11.1.7) and human alpha2-macroglobulin has been studied by employing starch gel electrophoresis and spectrophotometric assay analysis. | 53,181 | [
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-0.4124838,
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-0.1355098,
0.02603464,
-0.01367072,
0.1504909,
0.300221,
0.07702095,
0.147140... |
Anti-thymocyte serum may enhance or suppress the response to the same antigenic determinant. | Treatment of BALB/c mice with heterologous anti-thymocyte serum (ATS) increases their response to the C-polysaccharide of a rough strain of Pneumococcus, R36A, but suppresses their response to a vaccine of the whole organism. Phosphorylcholine is the major antigenic determinant for both the C-polysaccharide and vaccine... | 53,195 | [
-0.009985719,
0.0570529,
-0.3748831,
-0.1758623,
-0.09007806,
0.09081154,
0.04296587,
0.391104,
0.1611605,
0.3000185,
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0.1744645,
0.0665138,
0.1429131,
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-0.3077992,
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0.2304942,
0.3126455,
-0.05188832,
-0.2567551,
... |
Cytoplasmic antigens unique to the mycelial or yeast phase of Candida albicans. | Crossed immunoelectrophoresis with absorption in situ was used to distinguish the cytoplasmic antigens unique to the mycelial or yeast phase of Candida albicans from cytoplasmic antigens shared by both phases. The soluble cytoplasmic extracts of each growth phase had at least six distinct antigenic constituents not sha... | 53,205 | [
-0.1085164,
-0.06678817,
-0.03089835,
-0.1823624,
0.06416035,
-0.08680768,
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0.1024474,
0.2646781,
0.2178559,
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0.1252589,
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-0.5240215,
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0.09056946,
-0.07084,
0.4108326,
0.182135,
-0.07945774,... |
Defense mechanisms against bovine herpesvirus: relationship of virus-host cell events to susceptibility to antibody-complement cell lysis. | The interaction of infectious bovine rhinotracheitis virus and susceptible host cells was examined to determine whether an infected cell could be destroyed by humoral immune mechanisms before or after the transmission of virus to susceptible adjacent cells. Viral antigens were detectable on cell membranes at 6 h postin... | 53,206 | [
-0.1706428,
-0.3595662,
0.008058077,
-0.1410356,
0.0330455,
-0.2741302,
0.1270625,
-0.008331172,
0.09168345,
0.07830536,
0.08638288,
0.07452129,
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-0.330571,
0.01422558,
0.09813353,
0.07523401,
0.04033682,
0.1135617,
-0.031548... |
3alpha-Reduction of dihydrotestosterone in human normal and hypertrophic prostatic tissues. | The activity of 3alpha-reduction of dihydrotestosterone was located in both the particulate and the soluble fractions of human prostatic tissues. Activity of 3alpha-reduction was higher than that of 3beta-reduction under the incubation conditions employed; therefore, the main reductive metabolic pathway of dihydrotesto... | 53,218 | [
-0.2151242,
0.02312677,
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0.1240976,
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-0.3106753,
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0.1549624,
0.07477625,
0.3635733,
0.5127263,
-0.189666... |
Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein. | Pharmacological evidence is presented for the involvement of microtubules in the process of fast axoplasmic transport. A quantitative measure of the inhibition of axoplasmic transport in an in vitro preparation of rat sciatic nerve is described. The alkaloids colchicine, podophyllotoxin, and vinblastine, which are know... | 53,233 | [
0.02342488,
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0.01064279,
-0.2819635,
-0.01241585,
0.2678922,
0.1364952,
0.15458... |
Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies. | Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of antibodies that are spec... | 53,257 | [
-0.1836684,
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-0.01530323,
-0.09642085,
0.3337049,
0.2010113,
0.2293018,
-0.15744... |
Enhancement of human interferon production by neutral red and chloroquine: analysis of inhibition of protein degradation and macromolecular synthesis. | Two lysosomotrophic drugs, neutral red and chloroquine, enhance polyinosinic:polycytidylic acid-induced interferon production by a strain of diploid human fibroblasts (FS-4). Treatment of cells with neutral red or chloroquine between 2.5 and 3.5 h after induction increases interferon yields 16- to 64- and 4- to 16-fold... | 53,261 | [
-0.2617125,
0.09110413,
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0.1388559,
0.5313296,
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0.1174212,
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0.0200384,
0.4056893,
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0.06234894,
-0.1682161,
-0.230119,
0.2016782,
0.1523051,
0.1890728,
-0.1401442,
0.06... |
Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells. | The mechanism of alloantigen-activated spleen cell suppression of mixed lymphocyte reaction (MLR) is explored in this report. Activated murine suppressor spleen cells elaborated a soluble noncytotoxic factor which suppressed MLR responses by 55-95%. Generation of suppressor factor required both in vivo alloantigen sens... | 53,264 | [
0.02378125,
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0.2137012,
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0.3136348,
0.3653104,
0.04520467,
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-0.3689802,
0.2009737,
0.518075,
0.1082847,
0.04144764,
-0.1257873,
-0.... |
Induction of cytotoxic T lymphocytes against I-region-coded determinants: in vitro evidence for a third histocompatibility locus in the mouse. | Determinants controlled by the I region of the murine H-2 complex provoked the generation of cytotoxic T lymphocytes (CTL) in both a secondary and primary mixed lymphocyte culture. The stimulating determinants appeared to be controlled by loci within the I-A subregion. The target antigens of the CTL generated were pres... | 53,265 | [
0.01540953,
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0.00931625,
-0.04151225,
0.3634151,
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0.3747056,
0.3021496,
0.2688623,
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0.2247706,
0.08083677,
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-0.2241836,
0.0677625,
0.05742831,
0.4418476,
0.09484814,
-0.0037310... |
Cell-mediated lympholysis of N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-beta-anaylglycylglycyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by the H-2K and H-2D serological regions of the murine major histocompatibility complex. | Splenic lymphocytes from four C57BL/10 congenic mouse strains were sensitized in vitro to N(-3-nitro-4-hydroxy-5-iodophenylacetyl)-beta-alanylglycylglycyl-(N) modified autologous lymphocytes. The effector cells generated after 5 days of culture were assayed on a series of either N-modified phytohemagglutinin-stimulated... | 53,266 | [
-0.1317953,
-0.3597454,
0.04817873,
-0.06013332,
0.3561759,
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0.3965178,
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-0.6639519,
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-0.009953064,
0.4038103,
0.2793799,
0.1697982,
-0.2347423,
... |
[Antigens of the human placenta (author's transl)]. | The immunologic relations between mother, foetus and placenta are discussed and those antigens of the human placenta already characterized by their physico-chemical and immunochemical properties described. In diagnostics the detection and determination of placental proteins is used in pregnancy tests, for the evaluatio... | 53,318 | [
0.2221492,
0.004171595,
-0.03853536,
0.2261881,
0.148738,
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0.3722232,
0.3372093,
0.1506205,
0.1382968,
0.07899975,
0.2382019,
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-0.3390372,
0.2558948,
-0.1280018,
0.2659701,
0.3503266,
0.2631359,
-0.1666486,
0.1113... |
Early syphilitic hepatitis. | 17 out of 175 cases of early syphilis had clinical, biochemical, and immunological evidence of liver damage. Before penicillin therapy the histological appearance of the liver was abnormal in 14 of the 15 patients from whom biopsy specimens were obtained. In 7 cases, treponemes were seen in the liver. After two months'... | 53,374 | [
-0.01692719,
-0.03893544,
-0.2113232,
0.02957067,
0.1430785,
-0.363981,
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0.009815085,
0.2089217,
0.1880229,
0.2391983,
0.004188532,
0.2237095,
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0.02059486,
-0.02385854,
-0.1299084,
0.2414396,
0.3868379,
0.2389266,
0.07252384,
... |
Selective screening for breast cancer in Guildford. | A preliminary survey has been carried out to test the feasibility of screening a high-risk group of women for breast cancer, using clinical examination and low-dose mammography, before the establishment of a two-tier screening system of basic well-woman clinics for the over-25s, and breast screening clinics for those o... | 53,384 | [
-0.04932094,
0.1307819,
-0.208973,
-0.3817215,
-0.1368456,
-0.1156075,
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-0.1358244,
0.02829341,
0.3667097,
0.1287,
0.2196154,
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-0.1665029,
0.05142925,
0.13762,
-0.2919894,
0.5145146,
0.5112414,
0.0987609,
0.5977688... |
Decreased serum cholesterol-binding reserve in premature myocardial infarction. | Incubation of human serum with crystalline cholesterol which had been pulverised by sonication resulted in a measurable uptake of cholesterol by the serum. This uptake was designated "serum cholesterol-binding reserve" (S.C.B.R.). Among more than 200 men and women examined, S.C.B.R. values varied from less than 10 to o... | 53,493 | [
-0.2402359,
0.004972894,
-0.03615072,
-0.2529433,
0.1958152,
-0.1356024,
0.02727817,
0.05123425,
0.1533388,
-0.0826532,
0.166859,
0.2236394,
-0.2387404,
0.05143739,
0.02501186,
-0.381808,
-0.5445626,
-0.3632426,
0.140091,
0.2721517,
0.05433423,
0.3839694,
-0.2183028,
-0... |
Antigenic relationship between the surface antigens of avian and equine influenze viruses. | Influenza virus Equine 1 (A/equine/Prague/56) has a hemagglutinin which is antigenically related to the hemagglutinin of fowl plague virus strain Rostock (FPV) and a neuraminidase which cross-reacts with the enzyme of virus N (A/chick/Germany/49). After a single injection of chickens with Equine 1 virus no hemagglutina... | 53,781 | [
-0.3967075,
-0.2517451,
-0.07631132,
-0.3251519,
0.004036023,
-0.3218887,
-0.2904632,
0.141558,
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0.174349,
0.2114156,
0.01157369,
0.1682107,
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-0.075307,
-0.08917765,
-0.112369,
0.006157129,
-0.07164562,
0.2694066,
0.2322813,
0.1661933,
-0.5703548,
... |
DNA-synthesis on giant nuclear RNA by AMV DNA polymerase. | The reverse transcription of pre-mRNA isolated from rat liver or mouse Ehrlich ascites carcinoma cells with the aid of hot phenol fractionation technique is described. Pre-mRNA isolated at 85 degrees C is a more active template than the 65 degree C fraction. The addition of oligo(dT) as a primer strongly stimulated the... | 53,784 | [
-0.1513221,
0.06557626,
-0.4963125,
0.0770556,
0.4121296,
-0.1202646,
-0.1234433,
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0.3080043,
0.1961836,
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0.1592754,
-0.2635871,
0.2445988,
0.4230345,
-0.2255621,
-0.3036749,
... |
Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver. | Alpha-hexachlorocyclohexane (alpha-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two alpha-HCH dechlorinating enzymes at least; one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated... | 53,794 | [
-0.2796162,
0.1339392,
-0.09451825,
-0.06609181,
0.11428,
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0.2416043,
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0.289169,
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0.2227206,
0.3444307,
-0.09158254,
-0.08591508,
0.357508,
-0.01388667,
0.2... |
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