title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Application of correspondance factor analysis to function testing of the thyroid]. | Biological data concerning 249 thyroid patients have been treated by using correspondance factor analysis. This statistical treatment has enabled us to compare 2 types of associated tests (in vitro, in vivo) and to evaluate their respective contribution to the diagnosis of different thyroid diseases. There appeared als... | 53,803 | [
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[Value of separation on ion exchange resins of plasma iodine fractions. Comparison with Werner's suppression test]. | This was a study of 71 patients suspected of hyperthyroidism who had undergone a tri-iodothyronine suppression test. A study of circulating protein-bound iodine after separation on ion-exchange resins had been carried out before triiodothyronine administration, on the same patients. The results showed that the radioact... | 53,805 | [
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Contamination of anti-immunoglobulin reagents with antibodies to beta 2-microglobulin and other unrelated antigens. Effects on immunofluorescence staining of human lymphocytes. | IgG fractions from three of four rabbit antisera to Bence Jones proteins of chi-type were found to contain antibodies to beta 2-microglobulin and to stain 80%-100% of human blood lymphocytes by indirect immunofluorescence. Antibody fractions from these sera, which contained anti-beta 2-microglobulin but not anti-Ig, st... | 53,879 | [
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Identification of tissue-specific antigens and concanavalin A receptors on rat epidermal cells using a radio-immunoprecipitation method. | Iodination with lactoperoxidase - 125I- - H2O2 was used to label surface components of rat epidermal cells. Lysis of the cells in non-idet P40 resulted in the solubilization of tissue-specific antigens and of concanavalin A receptors. These specificities were demonstrated using a radio-immunoprecipitation method. The t... | 53,900 | [
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Rhesus lymphocyte alloantigens. III. Identification of new antigens. | Rhesus monkey lymphocytotoxic alloantisera were tested in 437 random unrelated monkeys and in members of 19 pedigreed families. Groups of sera or individual sera identified 11 specificities. Genetic analysis of the associations of these antigens revealed behavior consistent with the current concept of the major histoco... | 53,903 | [
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Short-term and long-term effects of plasmapheresis on serum proteins and immunoglobulins. | In order to evaluate the short-term and long-term effects of plasmaapheresis on serum proteins and immunoglobulins, the levels of alpha1, alpha2, beta, and gamma globulins, and IgG, IgA, and IgM were measured and statistically evaluated in 41 active plasmapheresis donors donating 500 to 1,000 ml of plasma weekly for up... | 53,919 | [
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[Effect of passive immunity on subsequent vaccination against swine fever]. | Studied was the effect of a serum paratyph and Aujeszky gammaglobulin injected 10, 15, and 20 days prior to the crystal-violet and the lapinized vaccine. If the animals were infected with a pathogenic swine fever virus 10 to 15 days after their treatment with serum at the rate of 0.5 cu. cm per kg, part of them died, a... | 53,938 | [
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[The spontaneous NBT-test in granulocytes of patients with juvenile rheumatoid arthritis]. | 30 patients with definite seronegative juvenile rheumatoid arthritis and 3 patients with tendosynovitis and unclear arthralgia respectively were examined by the nitroblue tetrazolium (NBT) test (46 tests). A positive result could be obtained in 72 per cent of the examinations. Patients with a joint manifestation of juv... | 53,963 | [
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The adaptation of fluorescence microscopy for Nocardia asteroides: a preliminary report. | The Fluorescence Microscope is extremely effective in revealing the presence and morphology of Nocardia asteroides. This has been effectively demonstrated when the Auramine Fluorochrome was decolourized with 1% H2SO4 and the interval of decolourization was limited to two minutes and thirty seconds. When Nocardia astero... | 53,968 | [
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[Cultivation of Neisseria meningitidis serogroup A on semisynthetic liquid nutrient media]. | In cultivation of meningococcus of serological group A in fluid semisynthetic medium of simple composition prepared on the basis of purified acid casein hydrolysate with profound splitting there were obtained microbial cultures with a density of 4-5 x 10(9) microbial cells per 1 ml after 20-24 hours of cultivation with... | 53,974 | [
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A comparison of the unlabeled enzyme method with immunofluorescence for the evaluation of human immunologic renal disease. | The application of the unlabeled enzyme method to immunostaining of human renal biopsy material is described. The specificity and sensitivity of this technic were compared with those of standard immunofluorescent staining procedures. The unlabeled enzyme method, although a lengthier procedure, has proven to be as speci... | 53,996 | [
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Nuclear diagnosis of disseminated cancer of the breast. Results of liver-, brain-, and tumor-directed imaging studies. | Radionuclide imaging technics to identify metastases in liver and brain have preductive values that show the expected variation depending upon the prevalence of metastatic disease in the population studied. Liver scanning combined with peritoneoscopy may prove more accurate than either study alone for routine use in st... | 53,998 | [
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The prevention, inhibition, palliation, and treatment of endometriosis. | Endometriosis is a variable and enigmatic disease. In this article an attempt has been made to describe principles of management for different groups of patients who have varying manifestations of pelvic endometriosis. Different methods are described for prevention, inhibition, palliation, and treatment of endometriosi... | 54,001 | [
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Drusen of the iris: in advanced malignant choroidal melanoma. | Drusen were found in the iris between the layers of the pigment epithelium and the dilator muscle in an eye of a 52 year old patient that contained a large malignant choroidal melanoma. The significance of this unusual observation in comparison to the common drusen of Bruch's membrane of the choroid is discussed. | 54,006 | [
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Immunological and chemical correlation between alpha-fetoproteins from human and several mammalian species. | Alpha-Fetoproteins of several animals were purified and their molecular weights, amino acid compositions and peptide maps were compared, demonstrating the close similarities. These data indicated that the alpha-fetoproteins of mammalian species have closely related antigenical and chemical structures. Rabbits and horse... | 54,014 | [
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Clinical significance of alpha2H-globulin. | Incidences of alpha2H were investigated in sera from patients with various malignant and nonmalignant diseases. With counterimmunoelectrophoresis, alpha2H was detected in a wide variety of neoplastic diseases, and also in nonmalignant hematological disorders. Diagnostic significance was described regarding primary hepa... | 54,036 | [
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Alpha-Glycerophosphate dehydrogenase (insoluble) and lactic dehydrogenase activities in the skeletal muscles of two insects. | The flight muscle preparations of the dragonfly Pantala flavescens and the aquatic beetle Cybister confusus showed extremely low levels of lactic dehydrogenase activity and high levels of alpha-glycerophosphate dehydrogenase (insoluble) activity. The activities of these two enzymes in the leg muscle of the beetle were ... | 54,055 | [
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Effect of thermal stress and dehydration on plasma levels of glucose, free fatty acids and growth hormone in the pigeon. | Pigeons were subjected to high ambient temperature and water deprivation for 3 days (28 degrees C, 31 degrees C and 36.5 degrees C respectively). After 3 days of heat stress and dehydration, the plasma levels of glucose, free fatty acids (FFA) and growth hormone (GH) were measured. Although the level of plasma glucose ... | 54,065 | [
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[Hypothalamo-hypophysial-thymic axis in the rat]. | Thymic extracts, with proved immunologic properties, decrease, in vitro, RNA and DNA synthesis of hypothalamic fragments of adult rat and have no effect on hypophysis culture; we found a similar action in vivo. Growth hormone inhibits the nucleic acids synthesis of thymic fragments; no action is found with hypothalamic... | 54,122 | [
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Changes in metabolite concentration in the plasma, liver and muscle of feed restricted Japanese quail exposed to cold. | Quail fed ad libitum and 50% ad libitum were cold exposed for several weeks, during time control quail remained at 21 degrees C. The concentration of plasma glucose, FFA, and uric acid, tissue glycogen and carcass fat content was measured at the end of the cold exposure period. Quail fed ad libitum showed no significan... | 54,130 | [
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[Thymus changes in chicks following treatment with small doses of insecticides]. | Effects of small doses of insecticides (Fenclorfos and Heptaclor) upon the thymus of chickens were followed. Treatment began at the age of 3 weeks and continued during 4 or 8 weeks. Doses used were: 1 ppm for Heptaclor and 1 ppm and 0.5 ppm for Fenclorfos. Total nucleic acid, total protein, RNA, DNA, and amino acid nit... | 54,154 | [
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[Improvement of the method of staining cationic proteins of the lysosomes of polymorphonuclear leukocytes in laboratory animals and man]. | Some methodological drawbacks of the previously offered by the author method for speedy staining of lysosomal cation proteins have been eliminated. The method is shown to be applicable for histochemical staining of lysosome cation proteins of human polymorphonuclear leucocytes. Staining is carried out on blood smears a... | 54,156 | [
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Percutaneous absorption of 14C-9alpha-fluoro-11beta,21-dihydroxy-3,20-dioxopregna-1,4-dieno (17alpha,16alpha-d)-2'-methyloxazolidine-21-acetate (L 6400) in rats, pigs and humans. Comparison with 3H-triamcinolone acetonide. | 1. The percutaneous absorption of a novel oxazolino corticosteroid, 14C-9alpha-fluoro-11beta,21-dihydroxy-3,20-dioxopregna-1,4-dieno[17alpha,16alpha-d]-2'-methyloxazolidine-21-acetate (L 6400) and 3H-triamcinolone acetonide (TA) was compared in rats, pigs and humans after application of a cream formulation to the skin ... | 54,172 | [
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The immunological properties of pyruvate kinase. II. The relationship of the human erythrocyte isozyme to the human liver isozymes. | We have examined the hypothesis that the human erythrocyte isozyme of pyruvate kinase (EC 2.7.1.40) is a hybrid of the two isozymes present in liver. Rabbit antiserum against purified human erythrocyte pyruvate kinase inactivates the erythrocyte isozyme and the major liver isozyme from human tissue but does not inactiv... | 54,192 | [
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Bacterial blocking activity of specific IgG in chronic Pseudomonas aeruginosa infection. | A factor has been demonstrated in the serum of some patients with chronic Gram-negative infections which specifically blocks bactericidal activity against the infecting organism. Sera with this factor, that had been obtained from patients suffering from chronic Pseudomonas aeruginosa infections, were fractionated by Se... | 54,231 | [
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Sex-dependent differences in the biosynthesis of pyrimidine nucleotides in rat liver after repeated administration of alpha-hexachlorocyclohexane. | Utilization of [2-14C]orotic acid for the synthesis of the pyrimidine components of the free nucleotide pool and RNA from isolated cytoplasmic ribosomes was investigated in the liver of female and male rats. In females, labeled orotic acid is incorporated relatively more into uridine than into cytidine nucleotides; the... | 54,245 | [
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RNA-dependent DNA polymerase from a cell line derived from the bone marrow of a patient with polycythemia vera. | A RNA-dependent DNA polymerase was isolated from a human cell line derived from the bone marrow of a patient with polycythemia vera. The purification procedure included chromatography on phosphocellulose and oligo(dT)-cellulose, and glycerol gradient centrifugation. The enzyme could be distinguished from polymerase A b... | 54,257 | [
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... |
[Staining of blood smears with rivanol in patients suffering from bronchogenic neoplasms]. | Blood smears of patients suffering from bronchiogenic lung cancer were stained with Rivanol and observed by means of the fluorescence microscope. The results were compared with those obtained by FEULGEN's method. It was found that a single intravenous infusion of cyclophosphamide 30 mg/kg did not change the picture of ... | 54,278 | [
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[Cytochemical studies in megakaryocytes in hematologic diseases]. | Bone marrow smears of 48 patients consisting of 12 normal cases, 36 patients with different haematological diseases-among them 9 cases of idiopathic thrombopenia, 4 cases of polycythaemia, and 9 cases of Hodgkin's disease - were examined cytochemically. Acid phosphatase, unspecific esterases, naphthol-AS-D-chloroacetat... | 54,299 | [
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0.0... |
[Cytochemical tests on sediment cells of malignant and benign exudates]. | In exsudate cells separated from serous body cavities of 29 tumour patients and 30 patients with inflammatory and congestive effusion in cardiac failure or liver cirrhosis respectively the activities of acid and alkaline phosphatase were determined. In addition to sudanophilia the cell content of glycogen and that of r... | 54,303 | [
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[Studies on the lipid composition in serum and lymphocytes in chronic leukemia]. | In 33 patients with chronic lymphatic leukaemia (CLL) the lipids were examined quantitatively and qualitatively in the serum and in the lymphocytes. Besides the 5 main categories of lipids, lysolecithin, sphingomyelin, lecithin and cephalin as well as cholesterol ester subfractions were determined according to their de... | 54,305 | [
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... |
Species specificity of thromboplastin. A phylogenetic study. | Having studied the influence of thromboplastin preparations derived from cold and warm-blooded species on the plasma of 12 vertebrates (carp, frog, turtle, hen, rabbit, rat, mouse, guinea-pig, ground squirrel, dog, sheep and man) we have established that among the species far from each other phylogenetically, the pheno... | 54,309 | [
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0... |
The preparation of the factors IX, II, and X concentrate by means of DEAE cellulos and its therapeutic effectiveness. | Starting from a plasma used for producing cryoprecipitate a concentrate was gained by means of adsorption on DEAE cellulose, the factor IX activity of which was six to thirteen times higher than that of the original plasma. Even the factors X and II are enriched to the same extent approximately. In patients with haemop... | 54,310 | [
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... |
[The effect of heating and drugs on HL-A antigens and their reactions with cytotoxins]. | In some instances the heating of lymphocytes for 2 to 3 minutes at 56 degrees C enhances HL-A antigens or makes it possible to detect these antigens by a twostage microlymphocytotoxic test on preheated lymphocytes only. Similar phenomenons are observed in some tannin (1: 40 000) or 0.1% phenol-treated lymphocytes and a... | 54,317 | [
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0.4281589,
0.3651767,
0.2999867,
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-0... |
Antigens of Streptococcus mutans: characterization of a polysaccharide antigen from walls of strain GS-5. | A cell wall-associated polysaccharide antigen was isolated from Streptococcus mutans GS-5 and appeared to determine serotype c specificity. Ouchterlony double-diffusion analysis of crude formamide extracts derived from purified cell walls of two serotype c strains (GS-5 and JC-2) showed complete identify when reacted w... | 54,338 | [
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... |
Preparation of carbon-14-labelled whole short ragweed pollen antigens. | A new method of labelling short ragweed pollen antigens with carbon-14 is described. The known ragweed antigens AgE, Ra3, Ra5 and several other antigens are radiolabelled. These components are biologically active, have a high specific radioactivity and a long half-life. | 54,344 | [
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... |
Flagellar hook protein from Salmonella SJ25. | From acid-disintegrated flagellar hooks of Salmonella SJ25 an immunochemically pure preparation of hook protein was obtained by column chromatography. The molecular weight of the protein determined by sodium dodecyl sulfate-gel electrophoresis was 43,000, whereas that of SJ25 flagellin was 56,000. The amino-terminal re... | 54,355 | [
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0.01... |
Mitotic chromosome condensation in the sperm nucleus during postfertilization maturation division in Urechis eggs. | Changes in the morphology of the sperm nucleus in the egg cytoplasm are mong the immediate events in nucleocytoplasmic interactions during early embryogenesis. Soon after its entrance into the egg cytoplasm, the sperm nucleus of various organisms increases in size with the transformation of condensed chromatin to a dif... | 54,357 | [
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0.01869279,
-0.2944... |
Transformation of cells by rous sarcoma virus: cytoplasmic vacuolization. | Chick embryo cells transformed by the Bryan "high titer" strain of Rous sarcoma virus (RSV-BH) are heavily vacuolated. A variety of microscopic techniques have been used demonstrating that the vacuoles are cytoplasmic, bounded by membrane, and are composed largely of water. Proteins, lipids, glycoproteins, glycolipids,... | 54,359 | [
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Effect of Bacteroides fragilis on the human erythrocyte membrane: pathogenesis of Tk polyagglutination. | Incubation of normal human erythrocytes with the supernatant of centrifuged culture of some strains of Bacteroides fragilis results in the exposure of Tk polyagglutination determinants on the erythrocyte membrane. These determinants are present on non papain-labile structures and are probably exposed by an enzyme mecha... | 54,368 | [
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0.3430663,
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Prenatal development of central optic pathways in albino rats. | The development of the central optic projections in albino rat fetuses has been studied using light and electron microscopic degeneration techniques and the horseradish peroxidase method for demonstrating axonal projections of neurons. The first optic axons to reach the region of the optic chiasm arrive at day 15. By d... | 54,370 | [
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0.3059578,
0.0987774... |
Conjugation methods in immunofluorescence. | We have described methods of labeling antibody preparations with FITC, TMRI, and RBI. The degree of labeling with FITC can be precisely controlled by using well-defined conjugation procedures and FITC of a known degree of purity. Our experience shows that relatively high F/P ratios of the order of 20 to 25 mug/mg are d... | 54,374 | [
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0.08894791,
0.0007311536... |
Application of fluorescent antibody methods in the analysis of plaque samples. | Direct FA staining for S mutans serotypes may be performed on smears made from plaque or strain isolates and on colonies attached to agar plates of black membrane filters. Staining with single conjugates directed to S mutans serotypes (a to e) as well as with polyvalent a-, b-, d-, f-fluorescein label and c-, e-rhodami... | 54,380 | [
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0.530646,
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0.1... |
Allergy to insect stings. II. Phospholipase A: the major allergen in honeybee venom. | In order to determine the proteins of major allergenic importance in honeybee venom (Apis mellifera) it was chromatographed on G-50 Sephadex. The four major protein peaks eluted were identified as hyaluronidase, phospholipase, melittin, and apamin. Testing these preparations on the leukocytes of 6 honeybee-sensitive pa... | 54,382 | [
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... |
Antigenic determinants of adenovirus capsids. II. Homogeneity of hexons, and accessibility of their determinants, in the virion. | We have tested the two principal theories which explain the previous finding that small amounts of type-specific antibody to the adenovirus hexon can neutralize infectivity, whereas even large amounts of cross-reactive antibody do not. a) It has been suggested that the type-specific determinants are especially prominen... | 54,389 | [
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Comparative pharmacokinetics of coumarin anticoagulants XV: relationship between pharmacokinetics of dicumarol and warfarin in rats. | The distribution, elimination, and anticoagulant effect of dicumarol and warfarin were determined in adult males rats following intravenous injection of single doses of these drugs in crossover experiments. The biological half-life of dicumarol ranged from 5 to 28 hr; that of warfarin ranged from 9 to 30 hr. There was ... | 54,415 | [
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0.1697125,
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0... |
Assay in the mouse for delayed-type hypersensitivity to murine leukemia virus. | Delayed-type hypersensitivity (DTH), assayed by footpad swelling, was induced in 6- to 8-week-old BALB/cCr mice immunized with formalin-inactivated, sucrose-banded murine type-C viruses. The DTH response was inducible with as little as 11.25 mug sensitizing antigen, was greatest after sc sensitization as compared to im... | 54,434 | [
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... |
Apparatus for patient-controlled administration of intravenous narcotics during labour. | The intermittent intravenous administration of narcotic analgesics had advantages over intramuscular administration, but is often impracticable. The design of a prototype apparatus is described, from which analgesic, pethidine, can be self-administered intravenously during labour. The apparatus consists of a syringe pu... | 54,518 | [
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0.2678655,
... |
Mycoplasma T strains and perinatal death. | In 23 out of 290 perinatal deaths in Addis Ababa, mycoplasma T strains were the only organisms responsible for congenital pneumonia and death. All but 2 of the infants were stillborn, 16 dying during the last six weeks of gestation. Infections apparently occurred through intact fetal membranes. | 54,632 | [
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... |
T and B lymphocytes in breast cancer stage relationship and abrogation of T-lymphocyte depression by enzyme treatment in vitro. | B and T lymphocytes have been measured in 100 women--71 patients with breast cancer and 29 controls--using sheep-erythrocyte rosetting techniques. Compared with controls (healthy women or patients with benign breast disease), there is a highly significant depression of T-cell percentage in all stages of breast cancer e... | 54,739 | [
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Healing of gastric ulcer during treatment with cimetidine. | 10 patients with benign gastric ulcer were treated with cimetidine 0-8 to 1-6 g/day for six weeks. Relief of symptoms was rapid. Endoscopy at the end of treatment showed that all the ulcers had healed. Healing was not associated with an improvement of acute atrophic gastritis nor with any change of gastric mucosal pote... | 54,742 | [
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0.01227888,
0.1654512,
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-0.10016... |
[Blood picture changes following single and prolonged oral application of ALG in the dog]. | Mongrel dogs were orally treated with 20 mg/kg ALG or NHG respectively. A significant decrease of the peripheral lymphocyte count was observed not only during 6 hours after the application of ALG but also during longtime observation. This lymphocytopenia was found to be between 30% and 50%. The effect of ALG after oral... | 54,847 | [
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[Carcinoma of the pancreas: palliative surgery (author's transl)]. | Among 1146 patients with diseases of the pancreas observed over a 15-year period, there were 234 cases of malignant duodeno-pancreatic tumors. This report concerns the intraoperative diagnostic methods and the various palliative operations available. There was a ratio of 13 males to 10 females, and the average age was ... | 54,854 | [
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... |
A rapid and simplified staining of juxtaglomerular granules with aqueous crystal violet. | The method described allows staining of juxtaglomerular granules in a deep purple colour against faint purple background and deep purple erythrocytes. Paraffin sections of mouse kidney fixed in 10% formalin buffered with phosphate are brought to water, stained 3 min in 0.01% crystal violet, rinsed in tap water (or stai... | 54,861 | [
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... |
Studies on bacteriophage T7 DNA synthesis in vitro. II. Reconstitution of the T7 replication system using purified proteins. | DNA synthesis in vitro using intact duplex T7 DNA as template is dependent on a novel group of three phage T7-induced proteins: DNA-priming protein (activity which complements a cell extract lacking the T7 gene 4-protein), T7 DNA polymerase (gene 5-protein plus host factor), and T7 DNA-binding protein. The reaction req... | 54,868 | [
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0.2333787,
0.5228418,
0.08546013,
-0.390999,... |
Genetic activity of niridazole in yeast. | Niridazole, one of several drugs presently known to be of value in the treatment of human schistosomiasis, was tested for its activity in inducing mitotic recombination in yeast. It was found that niridazole is genetically active when the treatment of yeast cells is performed in a rich medium (YPG-medium) under growing... | 54,875 | [
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Partial purification of a serum factor that causes necrosis of tumors. | Tumor necrosis can be induced in transplanted mouse methylcholanthrene-induced sarcoma by a tumor necrosis factor in the serum of mice infected with bacillus Calmette-Guérin and given bacterial endotoxin. Sera from normal mice, endotoxin-treated mice, and mice infected with bacillus Calmette-Guérin do not contain this ... | 54,919 | [
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On the chemical basis of chromosome banding patterns. | A comparative study of the staining characteristics of four reagents for human chromosomes has been carried out. The four reagents are: (I) quinacrine mustard, as an alkylating agent, (II) the dihydroxy derivative of quinacrine mustard, (III) quinacrine, and (IV) 9-amino-6-chloro-2-methoxyacridine. The last reagent doe... | 54,951 | [
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Influence of light and mounting medium on the fading of Feulgen stain. | Serial microspectrophotometric estimations of the absorbance of Feulgen-stained interphase nuclei of human fibroblasts were made on slides mounted in a variety of mounting media and stored in light or in darkness. All preparations showed some fading, at rates which varied with different mountants, were greater in the l... | 54,953 | [
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Primary antibody response against K and D regions of the H-2a and H-2d haplotypes. | The capacity of D and K antigens of the H-2d and H-2a haplotypes to induce primary IgM response was evaluated in host-donor combinations using congenic recombinant strains of mice. Host animals were immunized with an i.p. injection of 2 X 10(7) allogeneic spleen cells. Direct plaque-forming cells appearing in immune sp... | 54,966 | [
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[Age profile of the antihemagglutinins and antineuraminidase antibodies in type A influenza (author's transl)]. | Antineuraminidase and antihemagglutinating antibody studies were carried out in parallel in sera from subjects born in Bulgaria in 1968-1972, 1956-1960, 1946-1950, 1925-1935 and 1917-1920. It was found that the amount of both antineuraminidase and antihemagglutinating antibody in sera from normal subjects could vary de... | 54,996 | [
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[Urocytogram in the treatment with bleomycin]. | Even though Bleomycin is excreted in the urine in high concentrations, side effects in the urinary tract due to the chemical nature of this compound are seldom observed. With respect to treatment of gynecological carcinomas, it is, therefore, important to examine the effect that Bleomycin when treatment involves the us... | 55,014 | [
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[Use of the oblique illumination method for characterizing N. meningitidis cultures]. | The authors used the method of oblique illumination for detection of the state of the population of meningococcus cultures. In studying 48 strains there were revealed three types of fluorescence of the colonies: bright orange with a transition into greenish-light blue along the lower margin (the I type), bright light b... | 55,019 | [
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[The role of microsocial and psychological factors in the development of stable psychological changes in children]. | The author conducted a clinical study of 305 children with epilepsy, the results of which were correlated with stable psychic changes, microsocial, psychological factors and identical heredity. It was established that pathological personality traits in the parents, a situation of conflicts in the family and a wrong rea... | 55,024 | [
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Embryology of the epidermis: ultrastructural aspects. III. Maturation and primary appearance of dendritic cells in the mouse with mammalian comparisons. | The epidermis of mice ranging in age from prenatal day 17 through postnatal day 4 and, in addition, postnatal day 18, was studied with the electron microscope. In the 17 day fetus, the periderm may or may not be present and a stratum corneum is developing in the latter case. The cells of the strata spinosum and granulo... | 55,035 | [
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... |
Plasma cell granulomas in non-lipemic xanthomatosis: apparent induction by indomethacin. | A 71-year-old man with non-lipemic, generalized, plane xanthomas developed nodules and tumors within one month of starting indomethacin therapy. These enlarged and spread during 5 months of daily indomethacin but promptly and spontaneously involuted when the indomethacin was discontinued. Within 4 months, the nodules a... | 55,044 | [
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Localization of hepatitis B surface antigen in conventional paraffin sections of the liver. Comparison of immunofluorescence, immunoperoxidase, and orcein staining methods with regard to their specificity and reliability as antigen marker. | Hepatitis B antigen (HBAg) has been demonstrated in conventional formalin-fixed paraffin-embedded liver tissue by peroxidase and fluorescent immunostaining as well as by orcein. Complete locational and morphologic identity is seen between material stained by specific immunologic methods and by orcein. The antigen is re... | 55,076 | [
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[Do immunization of rabbits by N-acetylgalactosamine and a disaccharide linked to a protein produce anti-microbial antibodies (author's transl)]. | Rabbits were immunized with N-acetylgalactosamine linked to bovalbumine. They produced antibodies which precipitated this same sugar linked to human gamma-globulins but did not agglutinate Salmonella johannesburg which carry a side chain of N-acetylgalactosamine. The same immunization enhanced the titre of "natural" an... | 55,093 | [
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[Effect of gramicidin C on the formation and germination of Bacillus brevis var. GB (P+-variant) spores]. | The effect of gramicidin C added to the medium at various periods of cultivation in concentrations of 20, 40 and 100 gamma/ml on sporulation of P+-variant of Bac. brevis var. GB was studied. The most effective increase in the sporulation rate and percentage of the cells germinating into the spores was observed on addit... | 55,097 | [
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Cross-reactive antigens and lectin as determinants of symbiotic specificity in the Rhizobium-clover association. | Cross-reactive antigens of clover roots and Rhizobium trifolii were detected on their cell surfaces by tube agglutination, immunofluorescent, and radioimmunoassay techniques. Anti-clover root antiserum had a higher agglutinating titer with infective strains of R. trifolii than with noninfective strains. The root antise... | 55,100 | [
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Endodontic education. | Undergraduate endodontology is taught in Australian Universitiies in Restorative or Conservative departments. Courses generally consist of twelve lectures, three seminars and technique courses. Average clinical experience is six to eight endodontic treatments in anterior and posterior teeth. Comparison with American an... | 55,118 | [
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[Isolation of the pregnancy specific beta-glycoprotein (SP1) and antigen-related proteins by means of immunoadsorption]. | Purification of human pregnancy-specific beta1-glycoprotein (SP1) and antigenically related proteins of sub-human primates (chimpanzee, rhesus monkey, cynomolgus and baboon) was achieved by means of an immunoadsorbent technique. The immunoglobulins of a rabbit antiserum to human SP1 were isolated on DEAE-cellulose and ... | 55,283 | [
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[Electronmicroscopic and immunohistochemical studies on human lymphocytes]. | Lymphocytes from the blood of healthy individuals and of patients suffering from CLL were investigated by electron microscopy and peroxidase-immunohistochemistry. B-lymphocytes were labelled by heterologous, peroxidase-conjugated antisera directed against the Id-determinants of their membranes. T-lymphocytes were label... | 55,285 | [
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Blood group MN precursors as human breast carcinoma-associated antigens and "naturally" occurring human cytotoxins against them. | Blood groups MN active substances were found in benign and malignant human mammary glands. However, the precursor T (Thomsen-Friedenreich) antigen, as determined with human sera, occurred in all cancerous breast tissues tested but not in the benign mammary glands. Anti-T antibody, which is present in all human sera, wa... | 55,297 | [
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Immunologic approaches to the diagnosis of cancer. | A variety of immunologic approaches can be applied to the diagnosis of human cancer, and these have the potential advantages of specificity and sensitivity. Many tumor distinctive markers have been detected in the circulation of cancer patients. Cancer patients frequently have detectably depressed immune competence, bu... | 55,303 | [
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... |
Characterization of a new antigen-antibody system associated with hepatitis B. | The occurrence of a new antigen-antibody system was recently described in hepatitis B surface antigen (HBsAg) positive sera with different specificities, one of which was designated e. These specificities are related as demonstrated by the presently utilized e reagents not discriminating between them in immunodiffusion... | 55,324 | [
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... |
Method for the determination of mean densitometric profiles of chromosomes: application to human chromosomes stained by quinacrine mustard, ethidium bromide or by the Feulgen reaction. | When comparing the densitometric profiles of corresponding chromosomes registered from different metaphases or homologous pairs, one is always faced with the variability of their length and overall height. This makes difficult the quantitative comparison of a given chromosome treated by various staining procedures.--A ... | 55,336 | [
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The scalp topography of potentials associated with missing visual or auditory stimuli. | Averaged potentials time-locked to regularly presented visual and auditory stimuli and to the occasional random deletion of a stimulus were recorded from a scalp electrode array overlying the left hemicranium. The major components of visual and auditory evoked potentials and of the potentials associated with missing st... | 55,346 | [
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Maturation of the somatosensory evoked potentials in normal infants and children, with special reference to the early N1 component. | The early components of the somatosensory evoked potential (SEP) were analysed in 39 normal newborns in REM sleep, 35 normal awake children between 1 month and 9 years and 16 normal awake adults. Electrical pulses were delivered at random intervals to fingers of the contralateral hand. The SEP were averaged from severa... | 55,347 | [
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... |
Spatio-temporal organization of EEG in premature infants and full-term new-borns. | Inter- and intrahemispheric EEG relationships were studied as a function of maturation in new-born infants. The spatio-temporal organization of EEG activity obtained during the two stages of sleep described in new-born infants - quiet sleep and active sleep - was analysed in 9 full-term new-born infants and 5 premature... | 55,356 | [
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Detection of cyclic sleep phenomena using instantaneous heart rate. | The development of the Heart Beat Domain and the Fourier transform of the Heart Beat Domain (which we call the Beatquency Domain) has provided new and useful tools for the quantitative analysis of sleep level patterns. This method of analysis has produced remarkable intersubject as well as intra-subject consistency and... | 55,357 | [
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Levels of beta-trace protein and lysozyme in human amniotic fluids. | The levels of beta-trace protein and lysozyme were estimated in amniotic fluids from normal fetuses and from fetuses with neuraltube defects. The values of these proteins in normal amniotic fluids were found to be similar to those detected in fetuses with anencephaly and spina bifida. The levels of lysozyme were shown ... | 55,367 | [
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Cytochemical study of pseudoisocyanine stained human chromosomes. | Human meiotic and mitotic chromosomes were studied with N-N' diethyl pseudoisocyanine stain. Following methylation and oxydation, the staining allowed microscopic observation of slides with both monochromatic light and fluorescence. In addition, stained preparations can be permanently conserved. Preceeded by diverse me... | 55,377 | [
0.1231975,
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0.000005584834,
0.06745511,
0.05752242,
0.02905229,
-0.1741881,
-0.06935225,
0.5125878,
0.1767928,
0.1897902,
-0.003606783,
-0.09967732,
0.1524019,
-0.7526163,
-0.09332501,
-0.06637208,
0.2255501,
0.2224812,
0.1347274,
0.5229397,
0.2218908,
-0.119544... |
Inhibition of allergic reactions by chromoglycate and by a new anti-allergic drug (10-chloro-1,4,6,9-tetrahydro-4,6-dioxopyrido (3,2-g) quinoline-2,8-dicardoxylic acid). I. Activity in rats. | A new inhibitor of IgE-mediated allergic reactions has been studied in rats. This new inhibitor is chemically quite different from cromoglycate and shows qualitative and quantitative advantages over it. This new inhibitor possesses no bronchodilator or end-organ antagonism activity, but as cromoglycate acts by inhibiti... | 55,394 | [
0.08546913,
0.1288873,
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0.07646927,
0.02966133,
0.05960023,
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0.1272373,
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EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients. | After removal of SRBC rosette-forming T-cells from the peripheral blood, the residual, largely B-lymphocyte fraction of five infectious mononucleosis patients was found to contain 0.5-2% blast cells, positive for the EBV-determined nuclear antigen (EBNA). There was a rough parallelism between the presence of large lymp... | 55,396 | [
-0.1354002,
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0.001330045,
0.5176275,
0.1003492,
0.0252292,
... |
Glycoproteins in membranes of secretory granules of the anterior pituitary gland. | Rat anterior pituitary glands were examined by electron microscopy after staining with five different histochemical stains. Histochemical reactions were observed in the cell coat, cell membrane and the membrane surrounding the secretory granules in all anterior pituitary cells following staining with phosphotungstic ac... | 55,405 | [
0.2815408,
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0.04119886,
0.161718,
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0.1048771,
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... |
Light microscopic demonstration of myoid material in nuclei. | During the development of configurational staining methods for proteins of the myosin-fibrin group, nuclei showed staining properties similar to those of myofibrils. This dye binding could be attributed to nuclear alpha-helical proteins. More recent chemical and electron microscopic studies demonstrated actomyosins in ... | 55,409 | [
0.05166994,
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0.02311443,
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0.2303065,
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0.2448287,
0.8062368,
0.3280503,
-0.4010467,
-0... |
Fractionation of cells on a discontinuous Ficoll gradient. Study of subpopulations of human T cells using anti-T-cell antibodies from patients with systemic lupus erythematosus. | Patients with active systemic lupus erythematosus (SLE) had a decrease in a subpopulation of cells (fraction D) when peripheral blood lymphocytes were separated on a discontinuous Ficoll gradient. Preincubation of SLE cells at 37 degrees C for 30 min led to a marked decrease in this fraction, composed primarily of thym... | 55,418 | [
0.05050439,
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0.05527085,
0.3800816,
0.2181285,
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0.08428285,
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0.1384399,
0.1057789,
0.2115013,
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0.652158,
0.3494484,
0.1831632,
-0.2229391,
0.1... |
Polymerized ragweed antigen E. IV. The analysis of the stability of molecular size and antigenic reactivity of the polymer. | Ragweed antigen E polymerized by treatment with glutaraldehyde offers a potentially improved method for immunotherapy of human IgE-mediated pollinosis because studies have demonstrated that the polymer retains antigenic reactivity but has decreased ability to release histamine when these functions are compared on a wei... | 55,428 | [
0.08676296,
0.1438816,
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0.1488791,
0.2689441,
0.267561,
0.1053954,
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0.2155294,
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0.1846739,
-0.06843753,
0.2807618,
-0.0529653,
... |
T cell memory for the cytotoxic response to hapten-modified target cells. | This study describes the development of memory and cytotoxic murine T cells against syngeneic haptne N equals[N-(3-nitro-4-hydroxy-5-iodophenyl-acetyl)-Beta-alanylglycylglycyl] associated antigen. Memory activity in this system had the following characteristics. a) In vitro challenged cells primed in vivo resulted in a... | 55,441 | [
-0.3073955,
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0.2361014,
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0.3111853,
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0.3572108,
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0.4207,
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0.1043582,
0.06101046,
0.583681,
0.4225998,
0.1978658,
-0.07852663,
-0... |
Immunochemical analysis of water-soluble antigens of chick retina in the course of embryogenesis. | Water-soluble antigens of chick retina were investigated using rabbit antisera to total extract and to individual electrophoretic fractions of retinal extract by methods of immunoelectrophoresis and Ouchterlony precipitation test. In the retina of the adult chick six serum and eleven tissue antigens were demonstrated. ... | 55,449 | [
0.08229247,
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0.461154,
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0.4451681,
0.00976022,
0.3699943,
0.2378961,
0.09651286,
0.2690611,
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0.1015189,
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0.2202114,
0.02664402,
-0.0606751,
0.2103429,
0.2731041,
-0.1583298,
-... |
Modulation of regulatory mechanisms operative in the cyclical production of antibody. | Modulation of the cyclical response in rabbits to aggregated human gamma globulin (AHuIgG) was investigated in order to study some of the parameters involved in self-regulation of the immune response. Several mitogens (lipopolysaccharide [LPS], phytohemagglutinin [PHA], and concanavalin A [Con A]), when injected simult... | 55,457 | [
0.2792402,
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0.4710476,
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0.1199701,
0.2681922,
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0.08790488,
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0.2114122,
0.1416543,
0.2447999,
0.3816791,
0.03901226,
... |
3H-thymidine autoradiography of the CSF cells in cases of non-neoplastic disease. | Human CSF cells in cases of non-neoplastic disease of the central nervous system (CNS) were examined in vitro by 3H-thymidine autoradiography. Immediately after withdrawl by lumbar or ventricular puncture, the CSF was incubated in a sedimentation chamber at 37 degrees C for 1 hr with an admixture of 3H-thymidine at a c... | 55,487 | [
-0.3357166,
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0.004337748,
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0.1609816,
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0.2093527,
0.03126057,
0.2846021,
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0.0940425,
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0.3057745,
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0.3862828,
0.5718429,
0.1275787,
0.1724072,
0.0... |
Neuropsychiatric symptomatology with chronic renal insufficiency in the stage of compensated and decompensated retention. II. Peripheral nerve disturbances. | 80 strictly selected patients with chronic renal insufficiency with plasma creatinine values of 1.4-14.5 mg% were examined for clinical and electrophysiological signs of nephrogenic polyneuropathy. The motor symptoms complained of were cramps in 43.8% of the patients, "restless leggs" in 18.7%, muscular twitchings in 1... | 55,492 | [
0.02288594,
0.1431228,
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0.03329396,
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0.04590225,
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0.152843,
0.2883736,
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0.04885099,
-0.5012683,
0.01106534,
-0.04070031,
0.1514563,
0.117449,
0.2708401,
0.007886638,
... |
[The EEG after frontal and frontobasal skull and brain injury (author's transl)]. | Eighty-eight patients with confirmed frontal and frontobasal lesions were examined. The EEG changes were investigated according to type and frequency both after recent trauma and in the later stages (Fig. 1). The general changes showed mainly slight (Fig. 2B) and only rarely severe, dysrhythmias (Fig. 3A) which, howeve... | 55,493 | [
-0.2720666,
0.1083169,
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-0.2031646,
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0.3948189,
0.1389267,
0.003088787,
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0.3188178,
0.1271093,
0.1454531,
0.2331646,
0.2849173,
0.3714028,
-0.1613381,
... |
Failure of somatostatin to correct manifest diabetic ketoacidosis. | Juvenile diabetic patients were studied 60-72 hours after insulin withdrawal when moderate ketoacidosis had developed. Somatostatin infusion for 4 hours in five patients resulted in almost complete suppression of plasma pancreatic glucagon and growth hormone, a fall in plasma-cyclic-adenosine-monophosphate (A.M.P.) con... | 55,530 | [
-0.4548348,
-0.1044794,
-0.2325172,
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0.481424,
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0.2262971,
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0.002672254,
0.2833523,
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0.1955631,
0.05218649,
0.05293474,
0.1630188,
0.2143419,
-0.08251867,
-0.1871408,... |
Autoantibodies to Tamm-Horsfall protein, a tool for diagnosing the level of urinary-tract infection. | In sera from ten girls with acute pyelonephritis, antibodies of the IgG-class to Tamm-Horsfall protein were found in significantly increased titres; in contrast, titres in sera from six girls with acute cystitis did not differ from those of healthy controls. The results suggest that determination of Tamm-Horsfall antib... | 55,534 | [
-0.008251776,
-0.03804887,
-0.2135739,
-0.1979908,
0.007138197,
-0.1171492,
-0.3504634,
0.1048262,
-0.1779398,
0.06852243,
0.1233032,
0.4295531,
0.2562137,
0.117553,
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-0.2765622,
0.01287766,
-0.1588959,
-0.2991911,
0.03233676,
-0.1270339,
-0.2143863... |
Hyperprolactinaemia and luteal insufficiency. | Prolactin interferes with the function of the corpus luteum, as was demonstrated by repeatedly finding a short luteal phase in the ovulatory cycles of two hyperprolactinaemic women after prolactin supression by bromocriptine had been discontinued. In hyperprolactinaemic ovulatory cycles excretion of pregnanediol in uri... | 55,535 | [
-0.06310767,
0.0633731,
0.02925933,
-0.1838183,
0.1585624,
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0.01850092,
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0.06071253,
0.1596519,
0.2408328,
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0.2226458,
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0.1028769,
0.01831187,
-0.09055366,
0.1003258,
0.1921716,
-0.0871956,
0... |
Anticonvulsants and parental epilepsy in the development of birth defects. | The results of two studies, one in Finland and one in the U.S.A., raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself. In the U.S.A., drug-exposure information was collected before delivery in a cohort of 50... | 55,587 | [
0.03341605,
0.3367512,
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-0.0674623,
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0.05019195,
0.100133,
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0.3859038,
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0.3192512,
0.03522089,
0.07689858,
-0.2500052,
... |
Menstrual blood-loss with intrauterine devices. | The effect of three intrauterine contraceptive devices (I.U.D.)-Lippes D, Dalkon Shield, and Copper 7-on menstrual blood-loss has been studied serially by objective methods in 279 women. All the women had a minimum of two cycles following delivery, abortion, cessation of lactation, or previous pill or I.U.D. use. All p... | 55,650 | [
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0.1168592,
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0.1085008,
0.2073377,
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0.3439532,
0.2469701,
0.01899375,
0.1332932,
0.2899216,
-0.03591123,
-0.4126537,
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-0.04579836,
-0.08438527,
0.03062845,
0.1549079,
0.1261613,
-0.03408483,
0.0000300... |
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