title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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HLA-DW3 associated with coeliac disease. | 28 patients with coeliac disease (C.D.) were typed for the HLA-A, -B, and -D loci by several techniques. It was found that C.D. is primarily associated with the DW3 determinant and only secondarily with HLA-B8. The previously described association with HLA-B8 is explained by linkage disequilibrium between HLA-B8 and DW... | 55,781 | [
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Enhanced preservation of the ischaemic kidney with inosine. | The function of rat kidneys subjected to 60 minutes of warm ischaemia at body-temperature was notably protected by the prior administration of the purine nucleoside inosine as a 40 mg/ml solution maintained at 37 degrees C. With direct intrarenal arterial perfusion of the kidney at the onset of ischaemia or with intrap... | 55,837 | [
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The chemical nature of human atrial specific granules. | The nature of human auricular specific granules was assessed by a variety of cytochemical and histochemical methods. The specific granules were found to be argentaphobic when ultrathin sections of Araldite-embedded auricular appendages were stained according to the periodic acid-thiocarbohydrazide-silver proteinate tec... | 56,022 | [
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[Influence of nutrition on hormone secretion. I. Study in Agua Preta (author's transl)]. | A positive correlation between the circulating growth hormone levels and the nutritional status was reported in 9 children of both sexes, aged 1 to 6 years, suffering from 2nd degree malnutrition. The mean serum insulin levels, the mean urinary 17-KS and 17-OHCS levels were low before the dietary therapy. No significan... | 56,017 | [
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Induction of histamine release and desensitization in human leukocytes. | Histamine release from normal human leukocytes can be induced by anti-IgE or protein A from Staphylococcus aureus. After incubation in buffer at 37 degrees C for various time intervals or repeated washings with buffer, or both procedures, the leukocytes lose most of their reactivity to protein A, whereas the reactivity... | 56,030 | [
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[Lupus syndrome during treatment with isoniazid]. | In a young girl, aged 17 years, there occurred, 9 months after starting treatment with isoniazid and rifampicin, clinical signs of rheumatoid arthritis with facial erythema of vespertilio type. The presence of L.E. cells and antinuclear antibodies with a high titer, the rapid disappearance of all the clinical signs on ... | 56,040 | [
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HL-A8 and LD-8a in patients with myasthenia gravis. | The frequency of HL-A8 in myasthenia gravis is markedly increased in women (60-80%) but not in men. The MLC determinant, LD-8a, is frequently associated with HL-A8. Of the 37 female MS patients, 15 were LD-8a positive (41%), whereas of the males only one of seven was LD-8a positive. The frequency of HL-A8 was 68% in wo... | 56,059 | [
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[The effect of drugs on "sino-atrial conduction time" and on sinus-node automaticity in man]. | The effect of atropine, propafenone, and disopyramide on sinus node automaticity and "sino-atrial conduction" was tested in normal patients and patients with the sick sinus-syndrome. "Sino-atrial conduction time" was estimated indirectly by the extrastimulus technique. Atropine (n = 11) caused a significant increase in... | 56,094 | [
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[The influence of brain dysfunction on child development]. | In childhood and adolescence two forms of so-called ''psychoorganic syndrome" are distinguished. The early form, in the English and American literature called minimal brain dysfunction, impairs the entire development of the personality in its somatic and psychic aspects. It requires extensive therapeutic efforts. Early... | 56,104 | [
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Reversible inhibition of rapid axonal transport in vivo by lidocaine hydrochloride. | Rats were given standardized injections of 3H-L-proline into the trigeminal ganglion and 14C-lidocaine hydrochloride at the infraorbital foramen. The 3H-L-proline was always injected 2.5 h before removal of the nerve. Lidocaine, 1, 2, and 4%, produced a concentration-related inhibition of entry of 3H-labeled rapid axon... | 56,150 | [
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Gene dosage and antigenic expression on the cell surface of bovine erythrocytes. | Electron microscopic and serological techniques have been used to study the relationship between cell surface expression of bovine erythrocyte antigens and the genes coding for these antigens. Using cells which are genetically and serologically defined for their zygosity with respect to the Z allele, it was found that ... | 56,151 | [
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A trial of utilizing antibodies as carriers of alkylating agents. I. Influence of cyclophosphamide and chlormethine on antigenic properties of serum proteins. | Electrophorograms of human and rabbit sera before and after incubation with various concentrations of cyclophosphamide and chlormethine (Nitrogranulogen) were compared. Sera of rabbits injected with chlormethine and cyclophosphamide in therapeutic doses for humans were examined for antibodies reacting with homologous a... | 56,161 | [
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Antigenic determinants of hen egg-white lysozyme in delayed hypersensitivity. II. Antigenicity and immunogenicity of the N- and C-terminal peptide. | Various small fragments of (see article) which is one of the immunodominant groups of hen egg-white lysozyme (HL), were tested for macrophage migration inhibition (MMI) of peritoneal exudate cells (PEC) from guinea pigs immunized with HL. P17 was split in the middle with cyanogen bromide. The terminal portion of (see a... | 56,172 | [
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Rabbit collagenase. Immunological identity of the enzymes released from cells and tissues in normal and pathological conditions. | 1. The immunological cross-reactivity between rabbit collagenases from a variety of normal and pathological sources was examined. The specific antibody raised against collagenase secreted from normal rabbit synovial fibroblasts gave reactions of complete identity with collagenases secreted from fibroblasts derived from... | 56,176 | [
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Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions? | Histamine release by modified gelatin (Haemaccel) and dextran (Macrodex) has been demonstrated in volunteers by direct and indirect methods. In a pilot study of Haemaccel, histamine release was observed in six of seven volunteers. The highest plasma histamine concentration was 4.8 ng/ml, the lowest 1.7 ng/ml: two of th... | 56,183 | [
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Production of beta-(4-hydroxyphenyl)ethanol and beta-(4-hydroxyphenyl)lactic acid by Candida species. | Two crystalline compounds were isolated from the culture filtrates of Candida species grown in synthetic medium supplemented with L-tyrosine as the sole source of nitrogen. These compounds were characterized as beta-(4-hydroxyphenyl)ethanol (HOPEA) and beta-(4-hydroxyphenyl)lactic acid (HOPLA). The production of these ... | 56,213 | [
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Human nucleolar organizer chromosomes: satellite associations. | The D and G group chromosomes from cultured human lymphocytes exhibit single and multiple satellite associations when stained with silver. Unlike earlier methods this simple and highly repeatable procedure shows physical attachments between satellited regions of various acrocentric autosomes. After studying 1,000 satel... | 56,257 | [
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[EEG effects of sodium nitroprusside and hemodynamic references]. | A study was performed on baboons (Papio papio) of various hemodynamic and EEG effects of sodium nitroprussiate (SNP), substance with powerful vasodilator action. Three different procedures of drug injection were used: (1) in isolation, either in doses close to those used in clinical practice or in high doses; (2) after... | 56,263 | [
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Visual evoked response in senile and presenile dementia. | The visual cortical evoked response was studied in 19 patients suffering from a condition diagnosed as senile or presenile (type Alzheimer) dementia. When compared with a group of normal subjects used as reference group, the latencies of waves II through VI were increased or markedly increased in these patients, and th... | 56,264 | [
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Postnatal development of human brainstem potentials during the first year of life. | Average brainstem potentials evoked by auditory stimuli were recorded from the scalp's surface of human newborns and infants, 6 weeks, 3 months, 6 months and 1 year of age as well as from normal adults. The auditory processes related to peripheral transmission (PT) and central transmission (CT) were shown to mature at ... | 56,268 | [
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Specific immunological test for the rapid identification of members of the genus Histoplasma. | A sensitive and specific immunological method was developed for rapid identification of the mycelial forms of Histoplasma capsulatum var. capsulatum, H. capsulatum var. duboisii, and H. farciminosum and for separation of these pathogenic fungi from morphologically similar hyphomycetes and other fungal pathogens. This m... | 56,339 | [
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Quantitative fluorescence spectrophotometry of acridine orange-stained unfixed cells. Potential for automated detection of human uterine cancer. | After staining with acridine orange (AO), the nuclei of unfixed cells from the human female genital tract exhibited the same fluorescence behavior previously observed for human and murine leukocytes and mouse ascites tumor cells. With staining conditions chosen to assure saturation of the green-fluorescing AO-nucleic a... | 56,389 | [
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Dimethyl sulfoxide-lead tetraacetate method for histochemical oxidation of polysaccharides. | Oxidation of fixed tissues and unfixed peripheral blood smears by 1% (w/v) lead tetraacetate in dimethyl sulfoxide for 10 to 60 min resulted in facile induction of tissue carbonyls readily demonstrable with Schiff's reagent and by sodium bisulfite addition reaction, followed by toluidine blue staining at controlled pH.... | 56,394 | [
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Effect of proteolytic digestion on the structure and function of human properdin. | Human properdin (P) was found to be sensitive to the action of trypsin, chymotrypsin, pepsin, and Streptomycetes caesipitosus protease. Incubation of P with these enzymes resulted in loss of its functional activity and the production of antigenically deficient components compared to untreated P. Upon incubation with tr... | 56,403 | [
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Gangliosides as markers for murine lymphocyte subpopulations. | Antibodies to GM1 ganglioside were used to study murine lymphocyte populations. In A, AKR, and BALB/c mice, anti-GM1 reacts with thymocytes and peripheral T cells. This reactivity of anti-GM1, studied by immunofluorescence, is independent of Thy-1 type and appears to be related to the reactivity of cross-reacting antib... | 56,418 | [
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Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibody. | When the IgG1 fraction of anti-idiotypic antibodies raised in guinea pigs is injected into mice, sensitization of idiotypic T and B lymphocytes occurs (1-3). In the present study we analyze the genetic requirements for T-helper cell sensitization by anti-idiotypic antibody. This was done by measuring, in a suitable pan... | 56,419 | [
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Educational materials reviewed for AVLINE. | The need for a central source of information regarding the availability, suitability, and quality of educational materials has led to the development of AVLINE. AVLINE is a computer information service available through the MEDLARS system of the National Library of Medicine. The Association of American Medical Colleges... | 56,441 | [
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Comparison of histocompatibility antigens on cultured human tumor cells and fibroblasts by quantitative antibody absorption and sensitivity to cell-mediated cytotoxicity. | Human tumor and febroblast tissue culture cells were compared to determine the suitability of fibroblasts as control cells in experiments on human tumor serology and cellular immunology. Fibroblasts expressed the same HL-A antigen profile as did melanoma cells. Furthermore, the quantitative expression of the determinan... | 56,444 | [
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... |
Dissociation of alpha beta DNA polymerase of avian myeloblastosis virus by dimethyl sulfoxide. | The alpha beta DNA polymerase of avian myeloblastosis virus was treated with dimethyl sulfoxide to dissociate the enzyme subunits. The dimethyl sulfoxide treated enzymes were passed over phosphocellulose to purify and characterize the dissociated subunits as well as to remove the dimethyl sulfoxide. RNA-directed DNA po... | 56,461 | [
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Mechanism of interaction of avian myeloblastosis virus reverse transcriptase with avian myeloblastosis virus RNA. | The synthesis of DNA on avian myeloblastosis virus (AMV) RNA as the primer-template using AMV reverse transcriptase in vitro has been examined as a function of the concentrations of these components, as well as a function of the ionic strenth of the assay medium. The results are consistent with the hypothesis that two ... | 56,463 | [
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Effect of age and cigarette smoking on carcinoembryonic antigen levels. | Serum carcinoembryonic antigen (CEA) levels were determined by the Hansen-Z-gel technique in 276 healthy volunteers, of whom 154 were smokers and 122 nonsmokers. The mean CEA level was significantly higher in smokers (2.7 ng/ml) than in nonsmokers (1.9 ng/ml) (P less than .001), and a significantly higher percentage of... | 56,468 | [
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Reduction of menstrual blood-loss by prostaglandin-synthetase inhibitors. | Six patients with menorrhagia due to dysfunctional uterine bleeding and one patient with an intrauterine contraceptive device were treated with prostaglandin-synthetase inhibitors in an attempt to reduce their excessive menstrual blood-loss. Mefenamic acid (six patients) or flufenamic acid (one patient) taken during me... | 56,590 | [
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The activation of antigens of the basement membrane zone by proteolytic enzymes in vitro. | Following brief exposure of cryostat sections of human skin to the action of proteolytic enzymes (papain or trypsin), there was a pronounced increase in the antibody binding sites of the basement membrane zone, shown in indirect immunofluorescence by an increased intensity in fluorescence of the basement membrane zone ... | 56,855 | [
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Pharmacokinetics in drug therapy. I: Propranolol hydrochloride as adjunct therapy in the treatment of thyrotoxicosis. | A case study in which propranolol hydrochloride was used as adjunct therapy in the treatment of atrial fibrillation with rapid ventricular response, thyrotoxicosis and high output heart failure is presented to illustrate the pharmacokinetics of this drug. The relationship of propranolol dosage to blood levels, the effe... | 56,890 | [
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A new actinomycin complex produced by a Micromonospora species: fermentation, isolation, and characterization. | A species of Micromonospora, Micromonospora floridensis NRRL 8020, has been found to produce an actinomycin complex consisting of at least 25 active components. After solvent extraction of the complex, separation of the individual components was carried out by preparative thin-layer chromatography. Hydrolysis and subse... | 56,917 | [
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Chemically-induced temperature sensitive mutants of dengue virus type 2. I. Isolation and partial characterization. | Temperature sensitive (ts) mutants of dengue virus type 2 (DEN-2, TH-36 isolate) were induced by replication in primary hamster kidney cells treated with 5-azacytidine. Seven ts mutants were obtained from 138 clones isolated by an immunofluorescent cloning technique. Of these 7 ts mutants, 5 were sufficiently stable to... | 56,929 | [
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[An uncommon pseudo tumoral skin disease; the so-called Papillomatosis cutis carcinoides. A review (author's transl)]. | The review of the current literature on the subject is followed by the exposure of the clinical and histopathological data concerning a case of papillomatosis cutis carcinoides. The Authors conclude on the opportunity to maintain this nosographic pattern, to be enclosed among the cutaneous pseudo tumoral affections. | 56,941 | [
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Anaesthesia for cardioversion: a comparison of diazepam, thiopentone and propanidid. | Three groups of 50 patients were anaesthetized with diazepam 0.32 mg/kg or thiopentone 3.7 mg/kg or propanidid 4.6 mg/kg for elective carfioversion. Propanidid caused more hypotension than diazepam or thiopentone. Apnoea was most frequent following thipentone and excitatory side-effects were most prominent following pr... | 56,946 | [
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... |
Primary intracranial yolk sac tumor: immunofluorescent demonstration of alpha-fetoprotein synthesis. | An autopsy case of 20-year-old male with primary intracranial yolk sac tumor (endodermal sinus tumor) is reported. Whereas the biopsy specimen obtained from the pineal region showed diffuse proliferation of atypical tumor cells, the metastatic subdural tumor removed from lumbar spinal region had the characteristic hist... | 56,986 | [
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Production of antisera with specificity for malignant melanoma and human fetal skin. | Complement-dependent cytotoxic antibodies to common cell surface antigens of cultured melanoma cells were produced in guinea pigs. At appropriate dilution, melanoma antisera were cytotoxic only to melanoma target cells. Following absorption with pooled lymphoid cells, additional absorption with melanoma cells but not a... | 56,991 | [
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Effect of anti-alpha1-fetoprotein on alpha1-fetoprotein-producing rat tumors in vivo and in vitro. | Active or passive immunization of rats to alpha1-fetoprotein (AFP) does not consistently inhibit the growth of AFP-producing transplantable hepatomas in vivo, and anti-AFP does not kill these hepatomas in vitro. However, 3 of 14 rats in 1 experiment responded to passive immunization by reversal of tumor growth as evide... | 56,992 | [
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Isolation and characterization of an antigen of the bovine C-type virus. | By means of gel filtration and isoelectric focusing, an antigen of the bovine C-type leukemia virus was isolated in a highly purified form from extracts of infected cells. The antigen has a molecular weight of approximately 25,000 daltons and an isoelectric point of 6.4 to 6.6. In immunodiffusion experiments, the antig... | 56,993 | [
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Ultrastructural study of pulmonary bleomycin toxicity. | Ultrastructural manifestations of bleomycin A2 toxicity in the human lung were studied in three patients. In addition to the appearance of nucleolar fibrillar centers, an increase in membranous, beaded, and granular nuclear bodies was found in nuclei of type 1, type 2 alveolar epithelial cells, and interstitial fibrobl... | 56,994 | [
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Reference interval for maternal serum alpha-fetoprotein. | Maternal serum alpha-fetoprotein (AFP) concentration was measured in 237 samples taken throughout the pregnancies of 28 normal pregnant women who all gave birth to normal infants. The patterns from these 28 individuals curves were compared graphically with an earlier published non-parametric 90% reference interval base... | 57,017 | [
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Thalamic evoked potentials to somatosensory stimulation in man. | Thalamic somatosensory evoked potentials (ThSEPs) were recorded by averaging technique from various thalamic structures during 59 stereotactic operations. From 372 records, response patterns and latency characteristics were analysed in relation to the intrathalamic localization. The findings can be summarized as follow... | 57,036 | [
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[Contingent negative variation in 10-year-old children. Relations with the type of performance in a task of spatial localization]. | CNV magnitude was studied in a task involving spatial localization and discrimination Subjects were 18 children 10 years of age. The CNV amplitude of half the subjects increased when the performance decreased and, in the other half, CNV amplitude decreased when the performance decreased. However, it seems that CNV magn... | 57,043 | [
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Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes. | This study addresses itself to the problem of antibody formation in vitro by mouse splenic B lymphocytes enriched for reactivity to the hapten NIP by the hapten-gelatine binding and melting technique of Haas and Layton (1975). Small numbers of NIP-gelatine-bound B cells were placed in microcultures either by bulk dispe... | 57,094 | [
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Antigenicity of the M proteins of group A hemolytic streptococci: further evidence for shared determinants among serotypes. | Shared antigenic determinants between M proteins of group A streptococci appear to be widespread among serotypes. This is demonstrated by the ability of purified M proteins to absorb opsonic antibody from a variety of heterologous antisera prepared against whole cells or purified M proteins. This absorption procedure h... | 57,101 | [
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[A new instruction theory: possibility of a reverse flow of information from polypeptide sequences to RNA particularly in antibody synthesis, and the mechanisms of tolerance induction and immunosuppression (author's transl)]. | A new instruction theory for antibody formation is presented. The reverse flow of information from the amino-acid sequences of small antigenic determinants to an antideterminant RNA (aRNA) seems feasible. Prerequisites are specific activating enzymes, tRNAs, ATP as well as some kind of membrane assembling the anticodon... | 57,102 | [
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0... |
Histochemical localization of estrogen induced sulfated glycoprotein in rabbit uterus. | Histochemical localization of the estrogen-induced sulfated glycoproteins was made in the estrogen-treated rabbit uterus. Biochemical studies by a group of Endo et al, affirmed these particular glycoproteins were PAS-positive and metachromatic as stained with TB. No sign of digestion, however, has been detected in a se... | 57,108 | [
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Role of a lipopolysaccharide gene for immunogenicity of the enterobacterial common antigen. | It is known that only certain strains of the family of Enterobacteriaceae, notably rough (R) mutants with the type R1 or R4 core, evoked antibodies in high titers against the common enterobacterial antigen (CA) after immunization of rabbits with heated cell suspensions. The present investigation deals with genetic and ... | 57,114 | [
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The preparation, use, and evaluation of recorded material for teaching ultrasonics in a university Master of Science course in medical physics. | The potential value of using recorded instructional material in a university Master's course module in medical ultrasonics is discussed. The procedure for preparation and evaluation of a program of slides with synchronized audio tape is reported. The evaluation indicates that the flexibility of this form of recorded ma... | 57,123 | [
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Inhibition of antigen-induced histamine release by ouabain. | The effect of ouabain, a specific sodium-potassium dependent adenosine triphosphatase (Na+-K+-ATPase) inhibitor, on antigen-induced histamine release was studied using guinea pig lung fragments sensitized in vitro with rabbit antibodies against bovine serum albumin. Histamine was assayed spectrofluorometrically. When s... | 57,130 | [
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... |
Coexisting ventricular and blocked atrial parasystole. | A rare instance showing non-conducted atrial parasystole coexisting with ventricular parasystole is presented and a related subject is briefly discussed. The importance of recognizing parasystole is again emphasized because the ordinary extrasystoles, particularly ventricular in origin, are frequently digitalis-induced... | 57,203 | [
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Quantitative electromyography in the detection of the carriers in Duchenne type muscular dystrophy. | The quantitative EMG technique was used to detect Duchenne muscular dystrophy carriers. The tests were carried out, measuring the parameters of M.U. potentials (the duration, the phase, and the 0 index according to Van den Bosch, modified by Gardner-Medwin), and using the Willison analyzer, in a group of carriers and n... | 57,226 | [
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0.102228,
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The Paneth cell population of the small intestine of the rat-effects of fasting and zinc deficiency on total count and on dithizone-reactive count. | The distribution of Paneth cells in the rat small intestine was found to be approximately one per crypt in the duodenum, two to three per crypt in the jejunum and four to six per crypt in the ileum. The ileum has more Paneth cells containing dithizone-reactive zinc than the duodenum and jejunum. Zinc deficiency had no ... | 57,232 | [
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... |
Effects of ethanol on the permeability of toad urinary bladder epithelium. | Ethanol (9%) decreases the potential difference across the toad bladder when present at the mucosal surface, the short-circuit current was unchanged. The electrical resistance decreased indicating a change in ion movements across the bladder. Unidirectional 22Na and 36Cl flux measurements showed an increase in the move... | 57,235 | [
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0.01242172,
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Enhancement of encephalitogenic activity by the formation of myelin basic protein-brain acidic protein complex. | Encephalitogenic protein fraction (BEC) was isolated from bovine brain tissue by extraction with salt-ethanol mixture at neutral pH, instead of employing dilute mineral acid. The fraction BEC was separated into two fractions. An acid-soluble protein was encephalitogenic and the major component was very alike to the bas... | 57,252 | [
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0.1188171,
0.00169603... |
Doxorubicin/B.C.N.U. chemotherapy for multiple myeloma in relapse. | A combination of doxorubicin ('Adriamycin") and B.C.N.U. (1,3 di[2-chloroethyl]-1-nitrosourea) (30 mg/m2 of each intravenously every 3-4 weeks) was used to treat thirteen multiple-myeloma patients who did not respond or were in relapse after remission produced by alkylating-agent/prednisone therapy. All cases were stag... | 57,335 | [
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0.1823788,
0.1966077,
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0... |
Relation between postphlebitic changes in the deep veins and results of surgical treatment of venous ulcers. | 41 patients with venous ulceration, investigated by ascending phlebography, had operations to ligate incompetent calf perforating veins. Recurrent ulceration developed within five years of operation in all 23 patients with evidence of deep-vein damage on the initial phlebograms. Only 1 of the seventeen patients with no... | 57,339 | [
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0.246193,
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Man in transit: Biochemical and physiological changes during intercontinental flights. | Fifteen members of the passengers and crew of a plane flying from Buenos Aires to London have been studied, before, during, and after the 20-hour flight. Even allowing for circadian variation, there were clear rises in the urinary excretion of noradrenaline in the first part of the flight, and of both noradrenaline and... | 57,437 | [
-0.2093044,
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0.2675188,
0.035868... |
Breast and thyroid cancer and malignant melanoma promoted by alcohol-induced pituitary secretion of prolactin, T.S.H. and M.S.H. | In interview data from the U.S.A.'s Third National Cancer Survey, alcohol ingestion was associated with a higher occurrence of cancers of the breast, thyroid, and amlignant melanoma. Data from other studies support the first two associations. A unifying hypothesis to explain these seemingly diverse associations suggest... | 57,445 | [
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0.3913834,
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Place of azathioprine for Crohn's disease. | The clinical effects of azathioprine have been compared with those of corticosteroids in a group of 112 patients who have come under the care of a single unit between 1963 and 1975. There is no clear evidence that azathioprine alters the course of the disease in the long term; it is of value in obtaining a remission, p... | 57,449 | [
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0.2187311,
0.1085847,
0.1881775,
0.18568... |
Variable response to long-term 1alpha-hydroxycholecalciferol in haemodialysis osteodystrophy. | Ten uraemic patients on regular haemodialysis were treated with 1alpha-hydroxycholecalciferol (1alpha-H.C.C.) for 5 to 14 months. Five patients who had histological osteitis fibrosa with or without osteomalacia responded well, with resolution of musculoskeletal pain, return of raised serum-alkaline-phosphatase concentr... | 57,505 | [
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0.1695855,
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Comparison of antibody responses and reactivity of "Alice" and WRL 105 strain live influenza vaccines. | Groups of 45 adult volunteers were vaccinated intranasally with a single dose of either "Alice" or WRL 105 strain live influenza vaccines. Seroconversion rates against A/Scotland/840/74 were significantly greater following administration of WRL 105 but seroconversion rates against A/England/42/72, A/Port Chalmers/1/73,... | 57,520 | [
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... |
[Tumor antigens in the diagnosis of gastroenterological diseases (author's transl)]. | History, biochemical properties, techniques and normal range of carcino-embryonic proteins and their applications in clinical diagnosis are reviewed in detail. The importance of alpha1-fetoprotein, colon embryonic antigen, fetal sulfoglycoprotein, alpha2H-globulin and Regan-isoenzyme of alkaline phosphatase is discusse... | 57,561 | [
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0.0... |
[Experiments with splenohepatoplasty in the rat]. | The physiopathological premises for various methods of hepatic revascularisation are described and results wiht splenohepatoplasty in 40 rats are presented. This operation involves insertion of the upper pole of decapsulated spleen in the left hepatic lobe to create a new parenchymal supply and regenerate the liver cel... | 57,580 | [
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0.03087406,... |
Efficacy of tri-tab (T3 uptake diagnostic kit) under extreme temperature conditions. | A new surface adsorbent technique has been compared with the widely used resin sponge T3 uptake method. The new technique has the desired attributes, correlates very highly with the resin sponge method (r = 0.93) and has been accepted as a simple, rapid and reliable method under normal temperature conditions. However, ... | 57,627 | [
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... |
Serologic differences in strains of Sporothrix schenckii. | To obtain evidence that Sporothrix scheneckii enters the body by contact with contaminated materials, the antigenic property of strains from different sources was investigated. The reciprocal absorption test of the antisera against a soil isolate and a human isolate (KO 4606) showed that the absorbed antisera against K... | 57,646 | [
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[Lipodystrophia intestinalis (Whipple's disease)--a rare origin of a sprue syndrome]. | An own case of lipodystrophia intestinalis (Whipple's disease) of a male patient who was 41 years old at the time of the first admission is reported and discussed using literature. The biopsy of the small intestine is of decisive importance for the establishment of the diagnosis as well as for the long-term therapy wit... | 57,673 | [
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0.06217112,
0.2430593,
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[Reflex-dystrophic pseudo-arthritis or Sudeck syndrome (author's transl) ]. | Local bone- and tissue dystrophies identical with Sudeck's syndrome and progressing in 3 stages are called reflex dystrophies. In the 1st and 2nd stages complete recovery is possible, in the 3rd stage only irreversible dysptrophic-ankylosing defect-healing. Etiologic significance of causal factors discussed is not cert... | 57,675 | [
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0.1908092,
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[Sub-ppm determination of thiouraciles applicated as thyreostatics in meat by high pressure liquid chromatography (author's transl)]. | The thyreostatics 2-thiouracile, 4-methyl-2-thiouracile, and 2-propyl-2-thiouracile were extracted from meat and determined by High Pressure Liquid Chromatography to a limit of about one ppb. | 57,680 | [
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Mortality after laparotomy. A 10-year series. | The Department of Surgery at the University Hospital, Linköping has 133 beds and serves a population of 130000. During the 10-year period 1962-1971 35039 in-patient operations were performed, of which 16719 (48%) were laparotomies. If fracture surgery and urological operations are excluded (during the relevant period t... | 57,687 | [
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... |
Malignant lymphomas of the salivary glands. Review of the literature and report of 33 new cases, including four cases associated with the lymphoepithelial lesion. | Malignant lymphomas involving major salivary glands have been reported to occur in 31 cases. To these, we add 33 cases, 17 of which were studied in detail from the points of view of clinical presentation, classification (Rappaport), staging (Ann Arbor), therapy, and subsequent course. The parotid gland was involved muc... | 57,714 | [
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0.2689651,
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0.15824... |
Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations. | A case of acute monocytic leukemia (AMoL) studied by cytologic, histologic, cytochemical, ultrastructural, and cytogenetic technics is reported. The immature monocytes were characterized by strong fluoride-sensitive nonspecific esterase activity. Nuclear irregularity, prominent nucleoli, erythrophagocytosis, and pinocy... | 57,715 | [
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0.06506944,
0.2549381,
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Senile ectropion and entropion: a comparative histopathological study. | A microscopic histopathological study was done on 500 full-eyelid-thickness surgical specimens: 25 with the diagnosis of senile ectropion and 25 with that of senile entropion. Five different staining techniques were used. There appears to be significantly more orbicularis and Riolan's muscle ischemia, atrophy, and coll... | 57,735 | [
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0.05651614,
-0.044... |
Observations on the automated calculation of radioimmunoassay results. | Radioimmunoassay standard curves derived by four different automated calculation methods are compared with those derived manually for five assays of clinical importance (thyroxine, triiodothyronine, thyrotrophin, alphafetoprotein, and human growth hormone). The three curve fitting methods (linear or cubic regression on... | 57,737 | [
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0... |
Production, isolation, and properties of azetomycins. | Streptomyces antibioticus synthesizes five actinomycins that differ in the "proline site" of the molecule. When cultured in the presence of azetidine-2-carboxylic acid (AzC), antibiotic synthesis was stimulated 40 to 50%, synthesis of actinomycin IV was inhibited, and one or both prolines were replaced by AzC. AzC inco... | 57,738 | [
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... |
[Subtypes of serum hepatitis B antigen]. | Rheophoresis improved gel diffusion technique was used for the determination of subtypes of HB antigen (HBAg) according to D (ad + y) and Y (ay +, d--) specificity. Although the relative small number of carriers of antigen was investigated, it seems that the distribution of subtypes is somewhat different from the resul... | 57,774 | [
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... |
Excitability of human motoneurones after discharge in a conditioning reflex. | A new method of exploring the H reflex excitability cycle is proposed which permits the exploration of motoneurones that discharged in response to the conditioning shock. This is made possible by using a test stimulus supramaximal for the alpha motor fibres of the nerve, which causes a collision in the alpha fibres bet... | 57,856 | [
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0.3565769,
0.06367021,
0.2947... |
Regulation of slow potential shifts in nucleus reticularis thalami by the mesencephalic reticular formation and the frontal granular cortex. | Novel stimuli or electric stimulation of the mesencephalic reticular formation (MRF) produced large positive slow potentials (SPs) in rostral nucleus reticularis thalami (RVA) that accompanied the negative SPs known to occur in frontal cortex. SP durations (20-30 sec) were similar to the periods of unit inhibition that... | 57,857 | [
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Further studies on the possibility of differential demonstration of radicals of sulphur-containing amino-acids. | The authors showed that in rat liver and brain sections with blocked SH groups and split S-S bonds mercury orange stains some tissue structures after treating the sections with BAL. Considering that the blockade of SH groups with N-ethylmaleimide in is stable the authors set forth the hypothesis that the use of BAL may... | 57,909 | [
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0.03475... |
A neutral subtilopeptidase inhibitor from porcine serum some evidence for alpha2-macroglobulin. | An inhibitor of neutral subtilopeptidase [EC 3.4.24.4] was purified from porcine serum by salting out with (NH4)2SO4, chromatography on anion exchange sephadex, gel filtration with Sepharose 6B, and isoelectric focusing. The preparation was homogeneous by electrophoretic and ultracentrifugal criteria, and was shown to ... | 57,960 | [
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-0.2998715,
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-0.2822853,
-0.2522505,
-0.0127019,
0.1500982,
-0.04138862,
0.0347176,
0.1488867,
0.3240251,
-0.1704346,
-0.1021409,
0.2579003,
-0.1094091,
-0.1386294,
0.1568528,
0.3023423,
0.03706241,
0.1859609,
-0.141726,
0.0... |
Immunoassay of human TSH using dried blood samples. | A sensitive, semi-quantitative radioimmunoassay method to screen for elevations of TSH concentration in blood is described. The method requires two 0.32 cm dots of dried blood-impregnated filter paper (equivalent to 3 mul plasma) and a 3-day incubation. Separation of bound and free is obtained using polyethylene glycol... | 57,965 | [
-0.06858287,
0.08701761,
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0.03782519,
0.4492701,
-0.1239237,
-0.139856... |
Volatilization of lindance from water in soil-free and flooded soil systems. | Volatilization of 14C-lindane from water in planchets and under flooded soil ecosystem was investigated. Lindane disappeared faster than parathion from planchets. More rapid loss of both insecticides occurred from water than from chloroform. Loss of lindane and parathion was related to measured losses of water by evapo... | 57,974 | [
-0.09398925,
0.1965619,
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0.01999525,
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0.3673759,
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0... |
Early diagnosis of neonatal bacteremia by buffy-coat examination. | This study demonstrates the value of the buffy-coat smear examination in the early diagnosis of neonatal bacteremia. It is inexpensive, easy to perform, and relatively efficient. In most situations large numbers of bacteria could be seen in each positive smear. Unfortunately, the presence of a positive buffy-coat smear... | 58,058 | [
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0.04463677,
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0.1448714,
0.1025668,
... |
Mechanism of release of active alpha subunit from dimeric alpha beta avian myeloblastosis virus DNA polymerase. | Storage of the dimeric (alphabeta) form of avian myeloblastosis virus (AMV) DNA polymerase in glycerol resulted in the release of the smaller alpha subunit, as detected by glycerol gradient sedimentation. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of enzyme stored in glycerol showed the conco... | 58,080 | [
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0... |
Radiommunoassays for the 70,000-molecular-weight glycoproteins of endogenous mouse type C viruses: viral antigen expression in normal mouse tissues and sera. | Genetic information coding for type C RNA viruses is transmitted within the DNA of mouse cells. At least three endogenous viruses have so far been immunologically distinguished by radioimmunoassays for their 12,000-molecular-weight polypeptides (p12). In the present study, the 70,000-molecular-weight glycoproteins (gp7... | 58,081 | [
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0.0949449,
0.01110294,
0.1330332,
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-0.15594... |
[Recent details of the frequency and immunologic reactivity of sympathetic ophthalmia (author's transl)]. | When giving details of the frequency of Sympathetic Ophthalmia a clear distinction must be made between this disorder and the Phacogenic Ophthalmia also affecting the second eye. The latter is found with lens damage, whereas genuine Sympathetic Ophthalmia in relation to enucleation, eye damage and eye opening surgery a... | 58,086 | [
0.08400203,
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0.06744608,
0.2475712,
0.3036686,
0.2676756,
0.3244483,
-0.2199631,
0.12... |
Death in acute upper gastrointestinal bleeding. Can endoscopy reduce mortality? | In a retrospective analysis of 64 deaths from acute upper gastrointestinal bleeding in Edinburgh Royal Infirmary, 46 of the patients (72%) were found to have been over 60 years of age. Recurrent or continuous bledding occurred in 24 cases; after exclusion of deaths from sudden exsanguination (9) and from bleeding varic... | 58,212 | [
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0.1357666,
0.1699187,
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0.06628956,
0.2189005,
-0.379459... |
Pathogenesis of essential hypertension. | It is proposed that essential hypertension is an exaggeration of the tendency for blood-pressure to rise with age, that it results from a repeated sequence in which a small rise in pressure, possibly resulting from an autonomic nervous overactivity, produces changes in the kidney which maintain the rise of pressure and... | 58,262 | [
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0.03486624,
0.02163757,
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0.1362371,
-0.210774... |
Evidence of an agent transmissible from ulcerative colitis tissue. | Five New Zealand White rabbits were injected intracolonically with homogenates (100 mum) of ulcerative-colitis tissue. Histological changes closely similar to those seen in the human donors were present in the mucosa and submucosa of the large intestine of four of these rabbits 3-12 months later. Similar changes were s... | 58,307 | [
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0.4469194,
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0.5399358,
-0... |
Localization of alpha-fetoprotein in liver tissue of rats during postnatal development: comparison of the immunofluorescent and autoradiographic methods. | Localization of alpha-fetoprotein has been followed in the liver of rats of the Wistar strain from birth up to 37th day of life, and its presence was detected by means of the immunofluorescent and the autoradiographic methods. The former has shown alpha-fetoprotein to be localized in hepatocytes and the number of posit... | 58,388 | [
0.07304955,
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0.09674234,
0.01653167,
0.1596754,
0.2615413,
-0.08027... |
Labelling of bleomycin with cobalt-57, indium-111, technetium-99m, mercury-197, lead-203, and copper-67. | The radiochemical purity of the cobalt-57 complex of bleomycin could be enhanced by adjusting the pH of the final product to a value between 5 and 6. This radiopharmaceutical appeared to have better tumor visualizing properties compared to the not neutralized preparation. The clinical use of the cobalt-57 bleomycin com... | 58,409 | [
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0.2748664,
0.2258518,
0.6774459,
0.4546177,
-0.05653402,
0.3... |
Human pituitary growth hormone: restoration of full biological activity by noncovalent interaction of two fragments of the hormone. | The NH2-terminal 134 amino-acid fragment of the reduced-carbamidomethylated human somatropin molecule is found to react noncovalently with the COOH-terminal 51 amino-acid fragment in solutions of pH 8.4 at 2 degrees to restore full biological activity as evidenced by the rat tibia and pigeon crop-sac assays. In additio... | 58,417 | [
-0.2380404,
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0.3767887,
0.356233,
0.079721,
0.0083555... |
The 1971-72 epidemic of acute viral hepatitis in Godthaab, Greenland. | Viral hepatitis has been known to occur among the Greenland population endemically as well as in smaller and larger epidemics. A large epidemic of acute hepatitis comprising around 9% of the entire population, viz. more than 4000 notified cases, swept through Greenland between October 1970 and December 1972. 996 verif... | 58,437 | [
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0.02877482,
0.0733524,
0.1312194,
0.09148344,
0.1005801,
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0.1... |
The DNA provirus hypothesis. | I have discussed the observations and experiments that led to the formulation and establishment of the provirus hypothesis and the DNA provirus hypothesis, which includes RNA-directed DNA synthesis for the formation of the provirus. I have also discussed some aspects of the present status of our knowledge of the mechan... | 58,444 | [
-0.2400565,
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0.4907427,
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0.05381936,
0.04134621,
0.4181852,
0.06960761,
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... |
Assay of androgen binding sites by exchange with methyltrienolone (R 1881). | Methyltrienolone (R 1881 - 17beta-hydroxy-17alpha-methyl-estra-4,9,11-trien-3-one) binds specifically to androgen receptor in rat prostate cytosol where, unlike androstanolone, it is not metabolized. By exchanging bound endogenous hormone in rat prostate cytosol with labelled R 1881, it is possible to measure total (fr... | 58,452 | [
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0.3214989,
0.2415092,
-0.1463114,
... |
[Karyotypic analysis of human cell lines (CaVe and HeLa) by the method of differential staining of chromosomes]. | Karyological analysis of CaVe (human stomach cancer) and HeLa cell lines was carried out by means of differential Giemsa staining. In the CaVe cells 12 marker chromosomes were revealed, seven of them similar to those found in our HeLa cell strain. Four markers in our HeLa subline and seven in CaVe cells were similar to... | 58,478 | [
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0.1129487,
0.5384406,
0.167228,
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0.140761... |
[Sensitivity of m. kansasii strains to various antibiotics and chemotherapeutics in vitro and in vivo (author's transl)]. | Sensitivity of 40 strains of M. kansasii (var. luciflava) to various antibiotics and chemotherapeutics in vitro and in vivo was examined. The strains showed considerable individual variability in their susceptibility in vitro, most were more resistant to isoniazid and PAS and about one half of the investigated strains ... | 58,490 | [
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0.2398781,
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0.09970585,
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0.7462942,
0.3217103,
0.02913052,
-0.08193059,
-0.1... |
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