title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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RNA-metabolism in Streptomyces hydrogenans. Effect of 20beta-hydroxysteroid-dehydrogenase inducing dienediol on RNA-content and RNA-profile. | For the isolation of RNA and polysomes, logarithmically growing cells were disrupted by grinding with kieselgur. Other methods failed to produce undergraded m-RNA as shown by 10-50% sucrose gradient-centrifugation and electrophoresis in 2% mixed agarose-acrylamide gel columns. RNA was extracted by a modified phenol met... | 58,544 | [
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Bacillus subtilis RNA polymerase and its modification in sporulating and phage-infected bacteria. | Bacillus subtilis RNA polymerase holoenzyme consists of the subunits beta', beta, sigma, alpha, delta, and omega. In sporulating bacteria and in bacteria infected with phages SP01 and SP82, this enzyme undergoes changes in subunit composition and transcriptional specificity that could play a regulatory role in gene tr... | 58,549 | [
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Non-specific passive desensitization XX: two important technical details. | For non-specific passive desensitization to be effective two steps are necessary: (1) dialyze concentrated gamma globulin precipitated from plasma or serum by ammonium sulfate and (2) allow time for complete recovery from the initial reaction to antigen aerosols before giving the desensitizing dose of gamma globulin. | 58,571 | [
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Induction of tolerance in adult guinea-pigs by two antigen dosage levels and by antigenic competition. | The effect of prior injection of increasing doses of dinitrophenylated bovine serum albumin (DNP-BSA) mixed in Freund's complete (FCA) or incomplete (IFA) adjuvants on the antibody response to a subsequent challenge with an optimal immunizing dose of DNP-BSA in FCA has been examined and compared with the effect of comp... | 58,574 | [
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Antithymocyte globulin in renal transplant recipients. Report of a prospective randomized controlled trial. | Horse antihuman thymocyte globulin (HAHTG) combined with prednisone and azathioprine (lmuran) was used as immunosuppressive therapy in a randomized controlled sutdy in 50 renal allograft recipients. Side effects of HAHTG administration given intravenously were mostly mild. In the treated group, four patients out of 26 ... | 58,651 | [
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Progressive combined amyloid-elastic stain. | A progressive staining technique is described that will permit demonstration of elastic structures and amyloid deposits in the same section. It is satisfactory for animal as well as human tissues, and for both pericollagen and perirecticulin types of amyloidosis. | 58,656 | [
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[Change in lipid-protein interactions in the membranes of bacteria exposed to gramicidin S]. | Effect of cyclopeptide antibiotic gramicidin S on some enzymes and physical state of isolated Micrococcus lysodeikticus membranes is studied. Malate and lactate dehydrogenases were monotonously inhibited under the increase of gramicidin S concentration, while the activity of NADH-dehydrogenase firstly decreased and the... | 58,672 | [
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Use of the Brompton mixture in treating the chronic pain of malignant disease. | Physical, psychological, financial, interpersonal and spiritual factors all modify the appreciation of chronic pain. The Brompton mixture is a highly effective, flexible, safe and convenient means of controlling the chronic pain of malignant disease. The mixture is a solution containing morphine; the dose of narcotic c... | 58,709 | [
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Presence of blood group H antigen on a carcinoembryonic antigen, and its enzymatic modification into blood group A and B specificities. | A carcinoembryonic antigen (CEA-M) was purified from a hepatic metastasis obtained from a blood group O patient with cancer of the rectum. Using 125I-labeled carcinoembryonic antigen (CEA) and blood group antisera, H specificity has been found on the CEA-M. As the addition of anti-H to anti-CEA does not modify the exte... | 58,713 | [
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Precancerous changes in the stomach. | Intestinal metaplasia is often associated with human gastric carcinoma. Intestinalization seems to be a typical example of abnormal differentiation and is possibly a precancerous state. For investigation of intestinal metaplasia, a method for visualizing disaccharidases using Tes-Tape was developed; this method was app... | 58,722 | [
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Hyperthyroidism: diagnosis and treatment. | The clinical diagnosis in cases of suspected hyperthyroidism is very valuable. Laboratory diagnosis rests largely on measurements of circulating thyroid hormones, with radio-iodine studies playing only a minor part. No one test is infallible and some understanding of basic physiological considerations is essential if s... | 58,763 | [
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A glass-insulated "Elgiloy" microelectrode for recording unit activity in chronic monkey experiments. | A glass-coated microelectrode made of a stiff cobalt--nickel alloy is described. The thickness of the glass coating and the length of the uninsulated tip can be varied as desired. The electrode is stiff enough to insert through the relatively tough dura of the monkey in chronic experiments. Further, the recording site ... | 58,772 | [
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[The search for hematologic-immunological parameters with prognostic value in children with various tumors]. | In a total of 35 children affected with malignant sufferings (except leucaemias) the haematological-immunological parameters of children surviving for a short time are compared with those surviving for a long time. Compared with children surviving for a short time those surviving for long time had a more "normal" findi... | 58,813 | [
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Acid-fast properties and pyridine extraction of M. leprae. | The reportedly unique pyridine extractability of acid-fastness as an identifying characteristic for M. leprae was examined in the leprosy bacilli and in eight other strains of mycobacteria. The initial findings were, in general, in accord with previous reports except that M. smegmatis and M. phlei likewise demonstrated... | 58,845 | [
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Glycoproteins of Sendai virus: purification and antigenic analysis. | Solubilized envelope antigens (glycoproteins) of Sendai virus were purified in a DEAE-Bio-Gel A column. Monospecific antisera were prepared against the antigens, designated HN and F glycoproteins. These glycoproteins are antigenically distinct. Immunodiffusion analyses of the envelope antigens of three representative p... | 58,850 | [
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Lipoprotein from the outer membrane of Escherichia coli: purification, paracrystallization, and some properties of its free form. | In the envelope of Escherichia coli, is a lipoprotein of molecular weight 7,200 as a major envelope protein. This lipoprotein was previously shown to exist in two different forms in the outer membrane of E. coli: the free form and the boundform, which is covalently linked to the peptidoglycau. The free form of the lipo... | 58,861 | [
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Importance of full size complementary DNA in nucleic acid hybridization. | The size of the DNA product synthesized by RNA-directed DNA polymerase (isolated from avian myeloblastosis virus) was found to be important for complementary DNA (cDNA)-mRNA hybridization reactions. Incomplete cDNA to rabbit reticulocyte globin mRNA formed poor hybrids and presumably lacked sequences needed for hybridi... | 58,864 | [
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The effects of glutaraldehyde treatment and horesradish peroxidase conjugation on the immunoreactivity of bovine myelin encephalitogenic protein. | The effects of the immunoreactivity of bovine myelin encephalitogenic protein (EP) of treatment with glutaraldehyde and conjugation with horeradish peroxidase (HRP) were investigated by complement fixation and immunohistochemistry. Both glutaraldehyde treatment and HRP conjugation of EP decreased but did not abolish th... | 58,926 | [
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Quantitative studies of Gm allotypes. I. Reappraisal of the method using an autoanalyzer. | In this study, various parameters for the autoanalyzer hemagglutination-inhibition circuit applied to Gm studies, were examined. Details are given of modifications of this circiut and related methodology, that improve its precision and the reproducibility of results: use of a cells counter, effects of temperature, PVP,... | 58,943 | [
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High density lipoprotein (HDL) polymorphisms in rabbit. III. Quantitative determination of HDL and the inherited Hl 1 and R 67 antigens. | Immunological quantification of HDL and the inherited antigens Hl 1 and R 67 was performed on serum samples from two rabbit populations (Dutch and Albino) comprising a total of 106 animals. The female animals were found to have a higher concentration of both antigens and of HDL than the male animals. The amounts of ant... | 58,950 | [
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Streptococcal M protein extracted by nonionic detergent. I. Properties of the antiphagocytic and type-specific molecules. | Group A streptococcal M protein was extracted with nonionic detergent and subjected to a number of physical, chemical, and immunological tests. M protein thus extracted was composed of multiple protein bands, ranging from 35,000 down to 6,000 daltons, all having type-specific precipitating activity. The anti-phagocytic... | 58,958 | [
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Electron microscopy of tobacco mosaic virus prepared with the aid of negative staining-carbon film techniques. | The negative staining-carbon technique has been applied to suspensions of freshly prepared type strain tobacco mosaic virus particles in high concentrations. Electron microscope images show that paracrystalline arrays of the virus were formed, in which large areas of rods could be viewed along their long axes and in pa... | 58,964 | [
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Protein synthesis in zinc deficient rats during tularemia. | The effect of zinc deficiency on protein synthesis in rats during tularemia was studied. Five weeks prior to infection with the live vaccine strain of Francisella tularensis, rats had been assigned to one of three dietary groups: zinc deficient (-Zn), pair-fed (PF) or ad libitum (AL). Within 4 weeks, zinc deficiency ma... | 58,980 | [
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Pigment containing lipid vesicles. I. Preparation and characterization of chlorophyll a-lecithin vesicles. | Vesicles obtained by sonication of chlorophyll a-lecithin mixtures dispersed in anaqueous medium closely resemble the well-characterized vesicles similarly prepared from pure lipids. They are bounded by one spherical lipid bilayer which contains the chlorophyll a. Appropriate conditions for sonication prevent substanti... | 58,996 | [
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Plasma-urate measurements in predicting fetal death in hypertensive pregnancy. | The relation of perinatal mortality to plasma-urate concentrations and blood-pressure was studied in 332 pregnant patients with hypertension. Perinatal mortality was markedly increased when maternal plasma-urate concentrations were raised, generally in association with severe pre-eclampsia of early onset. Plasma-urate ... | 59,013 | [
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Is lactase the receptor and uncoating enzyme for infantile enteritis (rota) viruses? | Rotaviruses are now regarded as important causes of diarrhoea in man, cattle, pigs, mice, and possibly other animals. Characteristically, disease occurs in newborn and young animals, and infection seems limited to the differentiated gut epithelial cells. The major surface polypeptide of the calf scours rotavirus is gly... | 59,021 | [
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Von Willebrand disease San Diego, a new variant. | A reduced level of factor XII has been observed in 9 of 39 patients with von Willebrand's disease. This apparent common variant of von Willebrand's disease has not previously been described, and its significance is not known. | 59,075 | [
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Effect of beta-adrenergic blockade on plasma-renin activity and intractable hypertension in patients receiving regular dialysis treatment. | The effect of propranolol has been studied in two patients with chronic renal failure and hypertension which remained refractory despite the removal of excess sodium and water by dialysis. Measurements of plasma-renin, exchangeable sodium, and blood-volume demonstrated that in both patients hypertension was due to exce... | 59,151 | [
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0.03764791,
0.3973702,
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0.05600268,
0.04996793,
0.0734084,
-0.09600... |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. | 60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only. Of 31 patients with 4-hour plasma-paracetamol concentrations greater th... | 59,181 | [
-0.2872188,
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Electron microscopic studies of viral agents in Crohn's disease. | Viral agents isolated from ileal filtrates of patients with Crohn's disease have been successfully cultivated in continuous rabbit ileum tissue-culture and grown to titres sufficient to allow electron microscopic characterisation. Electron microscopic studies showed clusters of viral particles only in tissue-cultures i... | 59,238 | [
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Swine influenza virus and the recycling of influenza-A viruses in man. | Sera collected in 1967 and 1972 from people in the 0-100 age-group showed haemagglutination-inhibition (H.I.) antibody to swine virus A/Iowa/15/30 (Hsw1N1) in greatest number and with highest titre in people born before 1918. A slight decrease was observed from 1967 to 1972 in the number of sera with antibody to swine ... | 59,252 | [
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Alpha-fetoprotein in the serum of patients with neoplasms of the gastrointestinal tract. | Serum alpha-fetoprotein was estimated in 61 patients with neoplasms of the gastrointestinal tract, 29 healthy controls and 10 pregnant women. Almost half ot the patients had increased values of alpha-fetoprotein and no parellelism between alpha-fetoprotein and liver metastasis was found. Decreasing of the alpha-fetopro... | 59,318 | [
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0.0... |
Protein histochemistry methods for colloid identification to metastases of thyroid carcinoma. | Evidence for a thyroid origin of tumorous metastases may be facilitated by a histochemical determination of colloid. It is supported by the presence of proteins, demonstrable especially by the reaction for tyrosine, and a simultaneous absence, or only traces of acid mucosubstances. Contrary to existing literary reports... | 59,319 | [
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Origin of amniotic fluid alpha-fetoprotein in normal and defective pregnancies. | Alpha-fetoprotein was determined by electroimmunodiffusion and radioimmunoassay in 109 neonatal urine samples and 94 amniotic fluid samples. The samples were obtained from newborns and from pregnancies ranging in gestational age from 20 to 40 weeks. When alpha-fetoprotein values of neonatal urine and amniotic fluid wer... | 59,326 | [
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... |
Combination chemothereapy with cis-diamminedichloroplatinum (II) and bleomycin in tumors of the head and neck. | 28 patients with head and neck tumors not suitable for definitive treatment with radiation or surgery were treated with cis-diamminedichloroplatinum (II) and bleomycin in combination. Of 24 adequately treated patients, there were 3 partial remissions lasting for 3,3 and 6 months, respectively. Toxicity of the regimen a... | 59,332 | [
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Gastrointestinal changes in patients with hypogammaglobulinemia. | Three cases of hypogammaglobulinemia are described. In all cases the first symptoms of disease manifesting as pneumonia were preceded by diarrhea. In gastric biopsy there was atrophic gastritis with lack of plasmocytes. All patients demonstrated gastric achylia and symptoms of malabsorption syndrome. The causes of gast... | 59,351 | [
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Prostatic tissue cell growth and assessment. | The potential for use of cell and organ culture systems in the study of prostatic tumors is high. The nature of this organ and our lack of basic information about it limit the usefulness of in vitro techniques at present but these shortcomings can be overcome by concerted effort of interested investigators. At the pres... | 59,386 | [
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Alien cancers of the duodenum. | Invasion of the duodenum by contiguous cancer or an isolated metastasis can manifest itself with the signs and symptoms of primary cancer of the duodenum. Fourteen patients were identified with this type of diagnostic confusion. All of their tumors were in the second or third portion of the duodenum. Although the media... | 59,394 | [
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Cell mediated lympholysis in man. The impact of HLA-C antigens. | From a population of individuals, all HLA-A, B, and C tissue typed in relation to the Sixth International Histocompatibility Workshop, an experimental investigation has been performed to study the influence of the HLA-Cwl, w2, w3, w4, and w5 antigens in the Cell Mediated Lympholysis (CML) test. The average cytolysis ob... | 59,406 | [
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Hydroxyethyl lactamide, a dye solvent useful in vital staining. | In a search for new vital stains to reveal the microanatomy of nudibranch mollusks, the slow or very low solubility of many dyes in sea water posed a serious problem. Preliminary dissolution in tap water proved impractical. Hydroxyethyl lactamide, an odorless liquid and dye solvent was found ideal since it permits imme... | 59,418 | [
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... |
Improved microradiographic contrast for bone stain-historadiography. | Microradiographs of 5-micron sections of methyl methacrylate embedded undemineralized bone show poor resolution, but prestaining with silver nitrate increases the radioopacity of the calcified tissues to soft x-rays without masking regional differences in microscopic mineralization. Identical results are achieved using... | 59,423 | [
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Further evidence of heterogeneity within the Kidd blood group system. | Serological studies on blood of selected individuals show that red blood cells from individuals genetically JkaJk and JkbJk give single dose agglutination reactions with anti-Jka and anti-Jkb respectively, but react as strongly with anti-JkaJkb as do cells from random individuals. A Jk(a+b-) Oriental person has been fo... | 59,434 | [
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[Improvement of parenteral feeding through the additional administration of a serum protein solution]. | On 7 days - 5 postoperative - patients undergoing Billroth I or Billroth II were continuously infused apparatively witn an amino acid mixture of 100% and a glucose-xylitol-solution of 25% (group I). One group (group II) additionally received a serum protein solution. From the first preoperative day to the fifth day of ... | 59,474 | [
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0.02088789,
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... |
[Comparative studies on influences of physical and psychological strain on the ECG in coronary disease patients]. | In 7 patients suffering from heart infarction the electrocardiogram was telemetrically registered during telecast of the world championship in football 1974. The same patients were tested on a bicycle ergometer with standardized loads of 50, 75, 100 and 125 Watt for 3 minutes. Heart rate under psychial strain did not e... | 59,480 | [
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Assessment of the mid systolic click late systolic murmur syndrome by noninvasive methods. | In patients with the mid systolic click/late systolic murmur syndrome (MSC/LSM Sy) a ballooning, billowing or aneurysmal protrusion of one or both mitral leaflets has previously been described in angiographic studies. It is accepted that besides angiography noninvasive methods such as dynamic electrocardiography, phono... | 59,481 | [
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0.1... |
[Variable stainability of Purkinje cells]. | The author refers about different staining of the Purkinje-cells with luxol-fast-blue, gallocyanin, thionin and toluidin blue, chrom-alum-hematoxylin-phloxin, impregnation according to Palmgren, lithium and iron-hematoxylin, combination of the staining with phloxin and the Palmgren-impregnation and about the different ... | 59,483 | [
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... |
Histogenesis of mucin in follicular mucinosis. An electron microscopic study. | Many dilated cystic ergastoplasms, including their granular, filamentous contents, the developed Golgi apparatuses, and vesicles were observed in the cytoplasm of affected root sheath cells, which were accompanied by much amorphous agglutination of fine granular or flocculent materials in the interstices. These extrace... | 59,502 | [
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0... |
Apoptosis in lichen planus and several other dermatoses. Intra-epidermal cell death with filamentous degeneration. | In hyperplastic conditions of the skin, eosinophilic bodies are often observed in the epidermis and upper dermis. These have been named variously Civatte body of lichen planus and dyskeratotic cell of actinic keratosis. In the present studies, it was found that (i) these cells commonly contain whorls of distinct filame... | 59,504 | [
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... |
Molecular order of carbohydrate components in cell walls of bacteria, fungi and algae according to the topo-optical reaction of the vicinal OH groups. | Selective topo-optical staining of vicinal OH groups with aldehyde-bisulphite-toluidine blue (ABT) has been used for studying the molecular structural order of polysaccharide components in microbial cell walls and capsules. (i) By intensive metachromatic staining in the light microscope, the method demonstrates carbohy... | 59,521 | [
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0.07253493... |
The effect of rhizobiophages on the effectiveness of Rhizobium meliloti in symbiosis with lucerne. I. Effect of various strains of R. meliloti and rhizobiophages on the yield and nitrogen fixation in lucerne. | Pot and test-tube experiments were carried out on the effect of phages on yield and nitrogen fixation in lucerne inoculated with effective and non-effective strains of Rhizobium meliloti. It was found that some strains of R. meliloti became activated by the phages, which was reflected in an increase in yield and in cru... | 59,525 | [
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... |
Studies of blood clotting system during anaesthesia for prostatectomy. I. Epidural analgesia. | The studies were carried out on 20 patients operated on for prostatic adenoma under epidural analgesia. It was observed that activation of the fibrinolytic system is due to trauma to the prostate and is connected with release of plasmin activators into circulating blood. Epidural analgesia has no effect on the blood cl... | 59,555 | [
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Surgical management of carcinoma of the junction of the main hepatic ducts. | Twenty-six patients are reviewed who had primary carcinomas involving the junction of the hepatic ducts. The majority had had an initial procedure of palliative biliary diversion elsewhere and were referred for further treatment. In three cases, en bloc resection of the tumor with total hepatectomy and orthotopic liver... | 59,580 | [
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Creatine phosphokinase levels in children with severe developmental disturbances. | Serum creatine phosphokinase (CPK) levels were studied in individuals: 40 psychotic children suffering from childhood autism, atypical personality development, and childhood schizophrenia; five children with childhood aphasia; 22 children with severe personality disorders; 29 normal children and normal siblings of psyc... | 59,582 | [
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HLA typing. | I present an overview of HLA typing, a method of evaluating donor-recipient compatibility. The major histocompatibility system in man, the HLA region, considered to control the immunologic response to transplantation and perhaps to certain diseases, is discussed in relation to chromosomal location, chromosomal mapping,... | 59,584 | [
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Inhibition of denaturation of human gamma globulin by a mixture of L-histidine, L-cystine, and copper, and its clinical implication in rheumatoid arthritis. | A mixture of histidine, cystine, and copper mimicked gold thiomalate, N-ethylmaleimide, and p-chloro-mercuribenzoic acid in inhibiting sulfhydryl-disulfide interchange-mediated denaturation of human gamma globulin, bovine serum albumin, and diluted human serum. Measurable inhibitory effects were obtained with a mixture... | 59,600 | [
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A kinetic study of the inhibition of human and bovine trypsins and chymotrypsins by the inter-alpha-inhibitor from human plasma. | Human plasma inter-alpha-inhibitor forms 1:1 inactive complexes with human and bovine trypsins (EC 3.4.21.4) and chymotrypsins (EC 3.4.21.1). The association and dissociation rate constants as well as the equilibrium dissociation constants (Ki) of the complexes formed of inter-alpha-inhibitor and the four proteases hav... | 59,607 | [
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0.07229868,
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0.1024064,
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0.1796723,
0.08658494,
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0.06071001,
0.09738674,
0.1475045,
-0.3120985,
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-0.6851091,
0.009657698,
-0.01568228,
0.01719951,
0.05560813,
0.3881981,
-0.0996884... |
[Study of the complex between porcine plasmin and alpha2-macroglobulin (author's transl)]. | Porcine plasmin (EC 3.4.21.7) is obtained from plasminogen activated by human urokinase. This enzyme can bind, in an equimolecular ratio, to an alpha2-macroglobulin isolated from porcine serum. The number of active sites of plasmin has been determined through a burst titration of nitroaniline during the presteady-state... | 59,608 | [
-0.2383142,
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0.5218127,
0.6791242,
0.2116573,
-0.047164... |
Membrane characteristics of established human T- and B-cell lines. Cross-reactivity of human T-antigenic determinants with peripheral lymphocytes of non-human primates and the presence of MLC antigens on cultured T-cell lines. | Human T-cell lines (MOLT-4 and SOMMER-T) were injected into rabbits and monkeys (stumptail and squirrel monkeys). Rabbit anti-MOLT serum was absorbed with human liver and cultured B cells. Absorbed anti-MOLT serum was cytotoxic to lymphocytes of baboons and stumptail monkeys. Rabbit anti-MOLT and SOMMER-T sera after ab... | 59,650 | [
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0.4409136,
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Determinant competition during the immune response to N-acyl derivatives of ox insulin in the Hartley guinea-pig. | Subgroups of female Hartley guinea-pigs were immunized with N-carbamylated ox insulin, N-maleylated ox insulin, N-phthaloylated ox insulin, or with the crystalline ox insulin from which the N-acylated insulins had been prepared. The immunogens were administered in water-in-oil emulsions containing pertussis vaccine as ... | 59,652 | [
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... |
Serum alpha1-fetoprotein in cystic fibrosis. | In 38 children and adolescents with cystic fibrosis, in 19 normal children and 62 healthy adults the serum alpha1-fetoprotein concentrations were measured by radioimmunoassay. In cystic fibrosis patients 97.5% and in normal children 95% of the alpha1-fetoprotein values were within the normal range for healthy adults (1... | 59,665 | [
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0.1130772,
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Immunological investigations of antigenicity and specificity of soluble collagen fractions. IV. Anaphylaxis and allergy experiments. | Collagen prepared from rat, calf, or pig skin was tested on guinea pigs for active cutaneous anaphylaxis. Only one fraction of calf skin collagen gave a slight, positive reaction. No positive reactions were observed in 21 subjects submitted to patch tests and 12 subjects submitted to scratch tests with pig skin collage... | 59,667 | [
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0.1034098,
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Immunity after infections with Myxoviruses. | Influenza, parainfluenza and respiratory syncytial viruses cause respiratory infections in man with consequent transient and sometimes imperfect against reinfection. Humoral immunity and probably cell-mediated immunity contribute to resistance. Whereas circulating antibodies are more important for influenza viruses, se... | 59,707 | [
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... |
Somatic cell hybrids between human lymphoma lines. II. Spontaneous and induced patterns of the Epstein-Barr virus (EBV) cycle. | The regulation of spontaneous, IUDR-induced and P3HR-1 virus-induced EA and VCA production patterns was studied in two new somatic hybrids between human lymphoma lines. The hybrid 8A was derived from the crossing of the non-producer Raji with the spontaneous producer Daudi line. The second hybrid, 83, was produced by t... | 59,708 | [
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0.... |
Further characterization of phosphatase activities using non-specific substrates. | The demonstration of non-lysosomal acid phosphatase has been the subject of a number of recent investigations. In the present study we compared the enzyme activities in rat liver and kidney that are revealed after incubation in the presence of either beta-glycerophosphate, p-nitrophenylphosphate or phenylphosphate at v... | 59,721 | [
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0.4429429,
0.1134899,
0.1185197,
0.05038711,
... |
IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release. | Total secretory IgA and specific anti-antigen E (AgE) antibodies (ab) in the IgA and IgG classes were measured in concentrated nasal washings from ragweed allergic and normal individuals by antigen binding or anti-alpha-radioimmunoassays. Virtually all the allergic patients had significant IgA (45/49) and IgG (46/49) a... | 59,737 | [
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0.2994562,
0.1352642,
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-0.11525... |
Rosette formation between human lymphocytes and sheep erythrocytes. Inhibition of rosette formation by specific glycopeptides. | Rosette formation with unsensitized sheep erythrocytes is a characteristic of human thymus dependent lymphocytes. Release of glycopeptides from the sheep erythrocyte by trypsin reduces rosette formation. These tryptic glycopeptides inhibit rosette formation by untrypsinized sheep erythrocytes; this suggests that rosett... | 59,739 | [
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... |
X-ray microanalysis of zinc and calcium in ultrathin sections of human sperm cells using the pyroantimonate technique. | X-ray microanalysis of pyroantimonate-fixed sperm cells indicates the retention of calcium and zinc subcellularly in similar proportions to air dried cells. The ultrastructure is well preserved and is corelated with the analysis. Sodium, potassium and chlorine are all removed during the fixation. CAlcium and zinc are f... | 59,774 | [
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0.1429072,
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0.045... |
Histamine release by chemotactic, formyl methionine-containing peptides. | Certain formyl dipeptides and tripeptides containing methionine released histamine from human basophils at concentrations of 10(-4) to 10(-7) M. However, N-formyl amino acids did not release histamine. Tripeptides, in general, were more active than dipeptides. An acyl group was required for histamine release although a... | 59,783 | [
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0.07237215,
0.2024589,
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0.0921739... |
Humoral immune responses in Rana catesbiana frogs and tadpoles. | Rana catesbiana adult frogs and tadpoles were immunized with the bacteriophage F2, 0X-174, and T4 and the haptens 2,4 dinitrophenyl (DNP) and fluorescein (FTC). The haptens were conjugated with bovine serum albumin (BSA), bovine gamma globulin (BGG), or horsehoe crab hemocyanin (Hycn). Sera were obtained from immunized... | 59,790 | [
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0.00446877,
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... |
Measurement of diphenylhydantoin and phenobarbital by enzyme immunoassay and gas-liquid chromatography. | A new enzyme-multiplied immunoassay technique (EMIT) was compared with Kupferberg's gas-liquid chromatography (GLC) for the determination of diphenylhydantoin and phenobarbital. 116 plasma samples of patients with epilepsy were examined simultaneously by EMIT and GLC. The precision of repeated determinations was simila... | 59,797 | [
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0.06705871,
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0.4343282,
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0.1424668,
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0.022... |
The fatty acid composition of major glycosphingolipids (cerebrosides and sulfatides) in human cerebral white matter measured by a simple micromethod. | A micromethod for the investigation of the fatty acid composition of myelin glycosphingolipids (cerebrosides and sulfatides) suitable for general application in the investigation of neurological disorders, especially demyelinating diseases, is presented. Using the lipids extracted from 1 g of material these are freed o... | 59,798 | [
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0.2460475,
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0.1980097,
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... |
Interaction of human Waldenström's IgM proteins with guinea pig and human complement. | The activity of purified human Waldenström's IgM protein to fix complement of human and guinea pig origins was compared at different temperatures using the polystyrene latex particle-adsorption method. It was shown that the interaction of the IgM proteins with complement differed depending on the source of complement a... | 59,830 | [
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0.3561701,
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0.00001130283,
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Persistent gastrointestinal bleeding due to angiodysplasia of the gut in von Willebrand's disease. | Gastronintestinal vascular dysplasia as a cause of persistently recurring melaena is reported in two patients with von Willebrand's disease. Colonic wall vasculature was affected in one patient, the abnormality being demonstrated both radiologically and at operative hemicolectomy undertaken to control bleeding. Abnorma... | 59,851 | [
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0... |
"Self": standard of comparison for immunological recognition of foreignness. | It is suggested that the markers of biological individuality--i.e. the HLA antigens--may serve as the standard profiles against which foreignness is directly compared. | 59,859 | [
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... |
Appraising current therapy for breast cancer. 2. Irradiation. | The best combination of methods for managing primary breast cancer may not yet be known. Radiation therapy has been proved effective in decreasing the incidence of local and regional recurrence following mastectomy. Thus, until a superior regimen is established, I recommend local and regional irradiation for patients a... | 59,923 | [
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0.01881141,
0.08525565,
0.3281168,
-0.055... |
Euflavine: effect on brain heavy metal content and staining pattern, and on shuttle box behavior in goldfish. | Goldfish were exposed to euflavine in doses of 7-100 mg/l for 1h-14 days. The treatment resulted in a reduced stainability of the brain with the Timm histochemical procedure for "heavy metals". In contrast, analysis by flameless atomic absorption spectrophotometry showed no significant changes in the concentrations of ... | 59,934 | [
-0.3766169,
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0.3748857,
0.140034,
0.4659475,
0.1722108,
0.... |
Radiotherapy of metastases of mammary carcinoma. | Radiotherapy is a very successful way of treating localized metastatic or recurrent breast cancer. The success of treatment depends largely on the site of the metastasis and the dose applied. It is not a substitute for systemic treatment, but superior in the treatment of localized disease. | 59,936 | [
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0.04097794,
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0.2129632,
0.07701984,
0.002399423,
0.2906136,
0.1423234,
-0.01104... |
HLA antigen (A & B loci) frequency in Addisonian pernicious anaemia. | Sixty-six patients with Addisonian pernicious anaemia have been HLA typed and compared with 86 controls of the same ethnic group. No deviation in antigen frequency was found to be specific for the disease group as a whole. The most significant deviation found was an increased frequency of HLA-B8 in those patients with ... | 59,964 | [
-0.2285492,
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0.05512286,
0.09805161,
0.2237218,
-0.368158... |
[Blood group specific properties of leucocyte nuclei (author's transl)]. | The absorbing and precipitating capacity of leucocyte nuclear suspensions derived from conserved blood of various blood groups was examined with anti-A-, anti-B-, anti-H, anti-M-, anti-N-, and anti-CDE-, and anti-D-sera as well as with anti-AHP- and Evonymus-extracts. Nuclei of blood group A absorbed anti-A, but not an... | 60,008 | [
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0.4558285,
0.4402448,
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-0.4002459,
-0.2129... |
[The concentration of antibodies to several exoenzymes of beta-hemolytic streptococci in commercial preparations of gamma globulin]. | For the purpose of possible use of commercial preparations of homologous gamma-globulin in the outbreaks of streptococcus affections the authors studied the content of antibodies to some streptococcus antigens, namely to O-streptolysin, streptohyaluronidase and streptokinase. High antibody titres to streptokinase were ... | 60,017 | [
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0.2025922,
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0.4302167,
0.1424902,
0.8164586,
0.02408967,
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... |
[The effect of D-penicillamine on experimental allergic arthritis in rabbits]. | The effect of D-penicillamine on experimental allergic arthritis in rabbits (16 with arthritis and 15 controls) was investigated. After 40 days of treatment with D-penicillamine (intravenous) the arthritis had receded to a large extent. At the same time a maturation inhibition of the hematopoietic marrow had occurred i... | 60,013 | [
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0.2442882,
0.3176741,
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0.09782644,
... |
Intestinal absorption of L-tryptophan in scleroderma. | The purpose of this investigation was to study the intestinal absorption of L-tryptophan and to assess the absorptive function of the intestine in scleroderma. The oral L-tryptophan loading test was performed in 31 cases of systemic scleroderma (progressive systemic sclerosis, PSS) and 3 cases of localized scleroderma.... | 60,020 | [
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0.3348802,
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... |
Tricuspid atresia: results of treatment in 160 children. | Experience in managing 160 patients with tricuspid atresia is reviewed. The majority of these children require operative treatment in the 1st year of life. Clinical management of this rather complex anomaly is simplified by classifying each child according to total pulmonary blood flow. An overall plan of management fo... | 60,052 | [
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0.1993576,
0.3935314,
0.289208,
0.01119835,
... |
Improved staining method for differentiating immature germ cells from white blood cells in human seminal fluid. | A new staining method for differentiating WBCs from immature germ cells in seminal fluid has been studied. It is a combination of Bryan's sperm stain, which particulary stains the acrosomal cap of the spermatozoa and the spermatid, and Leishman's blood stain which stains the WBCs in the same way as found in blood smear... | 60,068 | [
0.1615954,
0.06920493,
-0.1825099,
0.08406816,
0.2041468,
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0.1104443,
0.1113798,
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0.183439,
0.2769898,
0.4101101,
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-0.04352545,
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-0.03001521,
0.4351478,
-0.01367632,
0.202084,
... |
Primary carcinoma of the liver. | Primary carcinoma of the liver is rare in Western countries but it is a common malignant tumour in many parts of the tropics. Much has been learnt in recent years about its pathology, manifestations, and aetiology that is relevant to the whole field of oncology. The important distinction between carcinomas of liver-cel... | 60,075 | [
-0.0213791,
-0.2994359,
-0.04212286,
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0.07257161,
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0.2452632,
0.07211259,
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0.1986318,
0.1019717,
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-0.1488654,
0.0670933,
0.2285592,
-0.009573875,
0.1564955,
0.1651612,
-0.3730... |
A colour reaction for the differentiation of ascomycetous and hemibasidiomycetous yeasts. | Seventy yeast strains, representative of twenty-six ascogenous genera, four saprobic hemibasidiomycetous genera and thirteen genera of the Cryptococcales were tested for their reaction with the stabilized aromatic diazonium compound, Diazonium Blue B salt. An aqueous, buffered solution of this compound gave a character... | 60,081 | [
0.094458,
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0.5383654,
0.1570696,
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0.3125043,
0.06623772,
-0.03879637,
... |
Attempts to identify viruses in rheumatoid synovial cells. | Synovial fibroblast cell strains derived from the synovial membranes of 7 patients with rheumatoid arthritis were examined for the presence of viruses, in particular leucoviruses. Seven similar synovial strains derived from patients with other arthritic conditions were used as a control group. Evidence of the presence ... | 60,087 | [
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0.05784638,
0.2896252,
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0.3867806,
0.3730701,
-0.2022595,
-0.08719712... |
Influence of the adrenal glucocorticoids on the stimulation of synthesis of hepatic ribonucleic acid and plasma acute-phase globulins by leucocytic endogenous mediator. | An injection of unpurified leucocytice endogenous mediator into rats results in an increased incorporation of [6(-14)C]orotate into hepatic RNA, an increase in the concentration of RNA associated with the bound ribosomal fraction of liver, and increases in the concentrations in serum of acute-phase proteins such as al... | 60,101 | [
-0.1020304,
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0.151721,
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0.05768579,
-0.3695672,
0.01798576,
0.2541027,
0.166274,
-0.01143651,
-0.239815... |
Observations on the pyridoxal 5'-phosphate inhibition of DNA polymerases. | Pyridoxal 5'-phosphate at concentrations greater than 0.5 mM inhibits polymerization of deoxynucleoside triphosphate catalyzed by a variety of DNA polymerases. The requirement for a phosphate as well as aldehyde moiety of pyridoxal phosphate for inhibition to occur is clearly shown by the fact that neither pyridoxal no... | 60,130 | [
-0.3288045,
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0.171144,
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0.2554745,
0.0599282,
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0.1554694,
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0.3913477,
0.2312461,
-0.05341772,
-0.2197726,
0.10... |
Alpha-foetoprotein and oestrogen metabolism. I. -Influence of alpha-foetoprotein on the metabolism of steroids by rat liver microsomes in vitro. | Rat alpha-foetoprotein (AFP) was shown to inhibit the formation of water soluble metabolities of oestrone and oestradiol by incubation with microsomes from rat liver in the presence of NADPH. The results support the proposal that in young animals the low activity of enzymes responsible of oestradiol metabolism may be d... | 60,142 | [
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-0.1592067,
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0.1002125,
0.1788092,
0.2880928,
0.2635065,
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-0.4654111,
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-0.2250292,
0.1209605,
0.03284729,
0.1606708,
-0.189424... |
Mesangial cell dysfunction detected by accumulation of aggregated protein in rats with streptozotocin induced diabetes. | Diminished renal glomerular mesangial phagocytic function has been found in rats with streptozotocin induced diabetes. Similar impairment was produced by high dose cortisone and growth hormone, whereas oestrogen had a stimulant effect. The findings could be relevant to the understanding of human diabetic nephropathy. | 60,145 | [
0.05781461,
0.01915742,
0.005561463,
0.02430496,
0.02504861,
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0.04862416,
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0.04304176,
-0.2086319,
0.1010219,
0.05718356,
0.1333204,
0.2126906,
0.1987482,
0.225507... |
The subcellular localization of calcium in vertebrate smooth muscle; calcium-containing and calcium-accumulating structures in muscle cells of mouse intestine. | The intracellular localization of calcium by means of cytochemical techniques was studied in smooth muscle cells of mouse intestine. When the lead acetate method according to Carasso and Favard (1966) was used calcium was found in mitochondria and sarcoplasmic reticulum and occasionally between the myofilaments. The ac... | 60,177 | [
-0.1434966,
0.03354889,
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0.4692989,
0.1372017,
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0.0004866837,
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0.09514468,
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0.1099372,
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0.2098324,
0.4704711,
0.2938485,
-0.09164382,
0... |
Enzymatic in vitro synthesis of globin genes. | Full-length, single-stranded rabbit globin cDNA, synthesized by AMV reverse transcriptase, apparently contains a small double-stranded sequence (hairpin) at the 3' terminus. This cDNA can serve as template-primer for E. coli DNA polymerase I, which synthesizes a strand complementary to the cDNA and covalently bound to ... | 60,178 | [
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0.02409862,
0.1391558,
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0.1687632,
0.0757395,
0.1111756,
0.1603514,
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0.05296742,
-0.6730698,
-0.008745563,
-0.02221598,
-0.06861955,
0.4164446,
-0.1855635,
-0.38614... |
[Morphological findings in the liver tissue of Australia antigen carriers]. | In twenty-four blood-donors were performed, after the average period of seventy-four days following the evidence of HB Ag in blood, the punction biopsies of the hepatic tissue. In microscopical examination one finding corresponded with the picture of a moderate, chronically persisting hepatitis, and in the twenty-first... | 60,181 | [
-0.0587529,
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-0.02997995,
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-0.4655101,
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0.01586304,
0.03653103,
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-0.07389072,
0.464781,
-0.00461009,
0.01930099,
0.2553212,
-0.... |
Hepatitis-B: a review. | The recent literature on various aspects of hepatitis-B is reviewed with emphasis on the interrelationships of viral structure, antigenic components, and host immune response in acute, chronic, and asymptomatic carrier states of the infection. The mode of replication and mechanisms of transmission are discussed. Specia... | 60,200 | [
-0.3220253,
0.06184687,
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0.1386863,
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0.1856175,
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0.2345015,
0.1058141,
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0.08960221,
0.4202596,
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-0.04592874,
0.1560487,
0.2209,
0.03706414,
-0.1577781,
-0... |
Contingent negative variation and the distraction--arousal hypothesis. | Thirty-two normal volunteers were tested in three conditions: (1) a constant-foreperiod reaction-time situation consisting of a flash--tone--key-press sequence (control condition); (2) the addition of a short-term memory task consisting of four letters presented within the flash--tone interval with the requirement that... | 60,215 | [
-0.1843849,
0.077069,
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0.4195827,
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0.3079083,
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0.07299861,
0.02609396,
0.3110177,
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-0.3172692,
-0.2002284,
0.09762738,
0.06697769,
0.01905939,
0.2274687,
-0.02598122,
0.01907383,
... |
Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602). | On account of the conflicting data concerning the action of 5-HTP on human sleep, repeated high doses were administered to three healthy subjects. The paradoxical sleep time and percentage tend to show a decrease during the 2nd week of treatment, followed by a rebound effect after the end of the treatment. In two subje... | 60,227 | [
-0.1434097,
-0.02622696,
-0.2078669,
-0.1895931,
0.1231807,
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-0.3778136,
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0.06580454,
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0.05609907,
0.333448,
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0.2137946,
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-0.4605949,
0.01103661,
-0.01299811,
-0.03708427,
-0.2528863,
0.2472901,
-0.108321... |
Paromomycin and dihydrostreptomycin binding to Escherichia coli ribosomes. | Paromomycin binds specifically to a single type of binding site on the 70-S streptomycin-sensitive Escherichia coli ribosome. This site is different from that of dihydrostreptomycin since paromomycin binds to streptomycin-resistant ribosomes and sine dihydrostreptomycin does not compete for paromomycin binding. Paromom... | 60,235 | [
-0.07051798,
0.3141775,
0.09640045,
0.0005958216,
0.03962089,
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0.1771305,
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0.186378,
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0.05544157,
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0.1037523,
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0.1135478,
-0.304485,
-0.0882949,
0.2349614,
-0.08925629,
0.2012958... |
[Identification of simian chromosomes by the differential staining method with Romanovskii-Giemza stain. II. Papio hamadryas]. | By means of differential staining with the Romanovsky - Gimsa dye the distribution of G-bands was studied in chromosomes of bone marrow cells and of cultured peripheral blood lymphocytes in Papio hamadryas. All the homologous chromosome pairs were identified. It was shown, as compared Papio hamadryas karyotypes with th... | 60,271 | [
0.1172367,
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0.03106351,
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0.1319036,
0.001348871,
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0.07283913,
0.06642044,
0.1179565,
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0.1043877,
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-0.350107,
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-0.07400315,
0.0963399,
0.6910245,
-0.1279073,
-0.0903767... |
The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve. | Axonal transport in primate optic nerve axons was studied by autoradiography, scintillation counting, and electron microscopy under conditions of short-term intraocular pressure elevation. With elevation of intraocular pressure to 30 mm. Hg below mean arterial blood pressure, blockage of transport was detected within 2... | 60,300 | [
0.1011439,
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0.02638189,
-0.01712491,
0.1861257,
0.09957938,
0.3750184,
0.1230944,
... |
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