title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Effects of phenethyl alcohol on Bacillus and Streptococcus. | The activity of phenethyl alcohol (PEA) on Bacillus cereus, B. megaterium, and Streptococcus faecalis was studied by electron microscopy of thin sections and by the assay of intracellular K+ leakage. S. faecalis was unaffected by PEA at concentrations up to 0.5%, B. cereus was severely damaged by 0.5% PEA, and B. megat... | 60,333 | [
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Lipid vesicle-cell interactions. III. Introduction of a new antigenic determinant into erythrocyte membranes. | The introduction of a new antigenic determinant, 2,4-dinitrophenyl-aminocaproyl-phosphatidylethanolamine (DNP-Cap-PE), into the surface membranes of intact human erythrocytes is described. Fresh cells were incubated in the presence of liposomes composed of 10% DNP-Cap-PE, 5% stearylamine, 20% lysolecithin, and 65% leci... | 60,342 | [
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Mobility restriction in vivo of the heavy ribosomal subunit in a secretory cell. | Analysis in insect (Chironomus tentans) salivary gland cells of labeled RNA as a function of time after precursor injection and its distance to the nuclear membrane, cytoplasmic zone analysis, could previously be used to demonstrate the presence of short-lasting gradients in newly labeled ribosomal RNA. Since the gradi... | 60,343 | [
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Single-strand nuclease action on heat-denatured spermiogenic chromatin. | The aim of this study was to compare the sensitivity of chromatin from representative cellular stages of spermiogenesis to a single-strandeded nuclease after heat denaturation. Thermal denaturation of chromatin was assayed in situ in fixed round, elongating and elongated spermatids and in testicular sperm from mice. Pr... | 60,438 | [
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Immune complex receptors on cell surface. I. Ultrastructural demonstration of macrophages. | A method is described for ultrastructural localization of immune complex receptors on the surface of viable peritoneal exudate cells. The technique entails incubation with a soluble complex of horseradish peroxidase (HRP) and specific antibody to HRP at 4 degrees C followed by exposure to diaminobenzidine and processin... | 60,441 | [
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Synthetic glycolipid adjuvants. | In the course of the organic synthesis of model compounds similar in some features to the lipid moiety of endotoxic lipopolysaccharide (LPS), Nacylated-D-glucosamine derivatives were prepared. One of these, N-palmitoyl-D-glucosamine, has been previously found to be mitogenic for athymic nude mouse B cells. This and oth... | 60,450 | [
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Cellular events in the induction of experimental allergic encephalomyelitis in rats. | Although both the T and B cells of the Lewis rat have immunoglobulin receptors for basic protein (BP) of myelin, and both cell types are required for antibody production to BP, the present results demonstrate that the T cells are the only cells required for the induction of experimental allergic encephalomyelitis (EAE)... | 60,461 | [
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Some chemical principles applicable to some silver and gold staining methods for neuropathological studies. | Some of the chemical principles involved in some silver and gold staining procedures for neuropathological studies are analyzed in the light of experience with methods for astrocytes, microglia, axons and reticulin fibers. The role of formalin fixation, and of treatment with ammonium bromide or oxidizing agents prior t... | 60,469 | [
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Vinyl acetate casts of emphysematous rat lungs. | Emphysema was induced in rats by chronic exposure to a papain aerosol according to established methods. The emphysematous changes were evaluated by previously described histological and biochemical parameters and by a new method employing infiltration of the lungs with vinyl acetate to make casts of the air spaces of t... | 60,483 | [
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Alterations in amounts and rates of serotonin transported in an axon of the giant cerebral neurone of Aplysia californica. | 1. The giant cerebral neurone of the sea hare, Aplysia californica, is a unipolar serotonergic cell. Its axon bifurcates, one branch travelling in the cerebrobuccal connective, the other in the posterior lip nerve. 2. I13H]serotonin was injected under pressure into the cell body of the giant cerebral neurone. We studie... | 60,486 | [
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Type C viruses from Kirsten sarcoma-transformed mink cells co-cultivated with primate cells and expressing p30 antigens related to feline leukemia virus. | Two type C viruses with new antigenic and biological properties were isolated by co-cultivating secondary cell strains established from the kidneys of a baboon (Papio papio) and a patas monkey (Erythrocebus patas) with mink cells non-productively transformed by Kirsten sarcoma virus. Both new isolates (designated PP-1R... | 60,495 | [
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Administration of human fibroblast interferon in chronic hepatitis-B infection. | One patient with hepatitis-B surface antigen (HBsAg)-positive chronic aggressive hepatitis, and two chimpanzee carriers of HBsAg, were each given seven doses of 10(7) I.U. of human fibroblast interferon over two weeks. The main differnce observed after treatment was a depression of the nucleocapsid hepatitis-0 core ant... | 60,513 | [
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Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity. Double-blind factorial trial. | The effects of timolol (10 mg thrice daily) and hydrochlorothiazide (50 mg/day) have been compared in a double-blind factorial trial in 20 patients with essential hypertension. There were four randomised test phases of 8 weeks each during which patients received timolol alone, hydrochlorothiazide alone, timolol plus hy... | 60,566 | [
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[Hepatitis: an international problem (author's transl)]. | Three kinds of virus hepatitis are recognized today: hepatitis A, B, and "non A-nonB". Hepatitis A is transmitted mainly by the anal-oral route, hepatitis B and probably also the third form of hepatitis principally by direct inoculation or close physical contact. Normal human immune serum globulin protects against hepa... | 60,698 | [
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[Incidence of viral hepatitis in travelers in the tropics. Experiences with gamma globulin prophylaxis (author's transl)]. | The occurrence of virus hepatitis during their residence was determined in 2755 persons returning from the tropics in 1975. The incidence was particularly high in those returning from India, Pakistan and Afghanistan. There was also a greater risk of the disease for travelers in Ethiopia, the countries on the West coast... | 60,699 | [
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The development of the blood-CSF barrier after birth. | The serum/CSF concentration ratio of alpha-2-macroglobulin is used as parameter to follow the development of the blood-CSF barrier throughout childhood. The decline of the protein permeability within the first year of life has all characteristics of a maturation process. The tightening of the barrier is thought to be t... | 60,727 | [
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Social learning approaches to health education: utilization of infant auto restraint devices. | There has been little critical evaluation of which methods achieve the desired results in health education. Using purchase of proper infant auto restraint devices as an objective, we assessed the effectiveness of three educational approaches. Only 37% of control families had purchased an acceptable car seat, compared t... | 60,736 | [
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An evaluation of a procedure for the isolation of myelin basic protein (BP). | A detailed description and stepwise evaluation of a procedure that can be used to obtain myelin basic protein (BP) from whole brain is presented. The procedure involved the 0.001 MHC1 extraction of whole brain pre-treated in a sequential manner with chloroform-methanol (2:1 v/v), acetone, and deionized water. This is f... | 60,758 | [
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Prenatal detection of anencephaly. | Fetal anomalies were suspected clinically in 3 patients, during the second trimester of pregnancy, due to advanced maternal age, hydramnios and abnormal vaginal bleeding respectively. Sonography revealed anencephaly in all of them, confirmed by roentgenograms and also by high amniotic fluid leveal alpha-fetoprotein in ... | 60,775 | [
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HLA and juvenile chronic polyarthritis. | HLA antigen have been identified in patients with juvenile chronic polyarthritis (J.C.P.) (n = 35). In J.C.P. the incidence of antigen B27 (57%) was found to be higher than in a normal population (n = 1,000). On recent evaluation of the clinical status, serology and x-rays, the patients with juvenile chronic polyarthri... | 60,796 | [
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[Antigenic analysis and immunological studies of the uterotropic bacterial strains SH6 and 01 isolated from aborted cows]. | The uterotropic strains SH6 and O1 were studied immunoelectrophoretically to establish their antigenic relationship. The more readily diffusing component of the O-antigenic fraction of the strains proved immunologically identical with LPA of the R Brucella organisms, while the slower component showed common determinan... | 60,821 | [
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Cell-mediated immunity in lumphocytic choriomeningitis. I. The specificity of the cytotoxic T lymphocytes. | The specificity of cytotoxic T lymphocytes (CTL) generated during murine lymphocytic choriomeningitis (LCM) has been investigated. CTL were obtained from the spleens of mice injected i.p. with LCM virus. The cytotoxic activity of the CTL was tested in an in vitro 51Cr cytotoxicity assay using infected macrophages or fi... | 60,840 | [
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Mixed leukocyte reaction in rats. Effect of immunization with bovine encephalitogenic protein and Freund's complete adjuvant. | Rats of certain strains immunized with bovine encephalitogenic protein (EP) in Freund's complete adjuvant develop an impairment of the mixed leukocyte reaction (MLR) similar to that seen in rabbits with experimental autoimmune encephalomyelitis and in humans with certain diseases, including multiple sclerosis. The rats... | 60,845 | [
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[Effectiveness of specific treatment of rabies. II. Analysis of cases of human death from rabies following a complete course of treatment with specific agents]. | Of 79318 persons treated of rabies in the Uzbek SSR in 1968--1974 there were recorded 16 cases of death of clinically manifest rabies. The course of treatment included injection of rabies gamma-globulin in a dose of 0.5 ml per 1 kg of body weight and the maximal dose of rabies vaccine. The incubation period lasted from... | 60,857 | [
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[Isoelectric spectra of hepatitis B antigen antibodies to it]. | Isoelectric focussing in a stable pH-gradient of ampholines, serum and fraction 4-4, containing hepatitis B antigen demonstrated that the antigen occupied the pI 4.31--6.03 zone with the maximum activity at pI 4.31--5.56. The activity of antibodies to the hepatitis B antigen was revealed in a donor serum and in the gam... | 60,859 | [
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[Neurotropic activity of the gamma-globulin fraction in the serum of schizophrenic patients]. | The report is concerned with the influence of the blood sera of schizophrenic patients on the electric activity of neurons in snails and its 3 fractions containing respectively nonprotein compounds, gamma-globulins and the remaining proteins. It was established that the amount of neurotropic activity only of gamma-glob... | 60,860 | [
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Cytology of serous effusions: a comparative study of two slightly different preparative methods. | A prospective study of 100 serous effusions was made by two slightly different technics of smearing cells from the centrifuged sediment onto glass slides. Those made with the cotton swab had greater cell concentration and better cell morphology than matching slides prepared by the pipette-"hematologic" two-slide techni... | 60,862 | [
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Statistical analysis of the different factors which could affect postextrasystolic potentiation in the human heart. | The effect of different coupling indices and intervals that could theoretically affect postextrasystolic potentiation has been investigated. A total of 150 ventricular premature beats corresponding to 20 patients submitted to routine cardiac catheterization were studied. Only single ventricular premature contractions f... | 60,878 | [
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0.08057102,
0.3383287,
-0.06036567,
-0.01... |
Protease inhibitors in plasma of patients with chronic urticaria. | The hypothesis that deficiencies of plasma protease inhibitors might play a role in the pathogenesis of chronic urticaria was evaluated. Plasma levels were measured in patients with urticaria and a matched control group for alpha1-antitrypsin, alpha2-macroglobulin, total trypsin-inhibiting capacity, kallikrein-inhibiti... | 60,915 | [
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Chemosurgery for skin cancer: fixed tissue and fresh tissue techniques. | Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed ... | 60,916 | [
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0.34... |
Lipoprotein lipase in the fat body of Triatoma brasiliensis. | Lipoprotein lipase activity was detected and characterized in the fat body of Triatoma brasiliensis one of the vector of Chagas' disease. The enzyme activity was close to a free fatty acid production of 47 mumol FFA mg protein-1-h-1 when assayed in the complete system. 2. The enzyme presented maximum activity at pH 8.... | 60,918 | [
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Effect of certain organic compounds on saliva secretion in sheep. | In two sheep fitted with esophageal cannulas the stimulation of resting saliva secretion by intrabuccal injections of volatile fatty acids (VFA) and of certain organic plant compounds was investigated. Volatile fatty acids, salicin and vanillin increased saliva flow rate by 100, 76 and 72% over 2.5 min after injection.... | 60,921 | [
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Susceptibility to insecticides of Lasioderma serricorne (F.) (Coleoptera anobiidae) grown on vitamin-deficient diets. | Variations in the susceptibility to pyrethrum and chlordane (two contact insecticides) of Lasioderma serricorne grown on different vitamin-deficient diets were studied and reasons for such variation were proposed. | 60,974 | [
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[Effect of curarization on sensitivity of chicken latissimus dorsi to electric current]. | (1.) To test the sensitivity to electric current of the latissimus dorsi and, therefore, its ability to yield action potential, we have studied the effect of curarisation on the amplitude of the isometric tetanus during "massive" stimulations by alternative current. (2.) Curarisation causes a considerable but reversibl... | 60,976 | [
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Post-tetanic changes of depressor responses evoked by stimulation of the aortic nerve. | The effect of changes in duration of the conditioning tetanus on the size of the testing depressor response was studied in rabbits anaesthetized with urethane. Depressor responses were evoked by stimulation of the aortic nerve. The interval between the conditioning and testing stimulation was fixed at 40 and 120 sec. ... | 60,979 | [
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[Morphological studies on cellfree induced sarcomas in syrian hamster (author's transl)]. | Morphological studies on sarcomas induced in syrian hamsters by cellfree transmission are described. The tumour tissue for the cellfree preparations stemmed from a sarcoma, containing C-particles. Basically, three histological groups have been distinguished: 1. neoplasms of the peripheral nerve-sheath, 2. undifferentia... | 60,983 | [
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... |
The similarity of changes in segmental contraction patterns induced by postextrasystolic potentiation and nitroglycerin. | Despite a fundamental difference in their underlying mechanisms, both postextrasystolic potentiation (PESP) and administration of nitroglycerin (TNG) have been utilized to predict reversibility of abnormal segmental wall motion in patients with ischemic heart disease. To determine whether these interventions induce the... | 61,073 | [
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Serum cholesterol and bile acid in primary hepatoma. | The close relationship between serum levels of cholesterol and bile acid has been confirmed in 46 patients with primary hepatoma. Serum levels of cholesterol and bile acid are roughly correlated with serum alpha-fetoprotein concentration. Because the relationship between serum cholesterol and bile acid did not exist in... | 61,074 | [
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The length of parallel fibers in the cat cerebellar cortex. An experimental light and electron microscopic study. | Experimental light and electron microscopic studies were carried out to determine the length of parallel fibers in the cat cerebellar cortex. Using a fine surgical knife, vermal and hemispheral folia were cut perpendicular to their long axis. The animals were sacrificed 1-10 days after the operation. Sections of the tr... | 61,126 | [
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Correlation of light and electron micrographs of human metaphase chromosomes after incorporation of BUdR and staining with "33258 Hoechst" and Giemsa. | Stained (Giemsa, "33258 Hoechst"1) and "33258 Hoechst" + Giemsa) and unstained metaphase chromosomes from human peripheral lymphocytes, after two rounds of replication in the presence of 5-bromodeoxyuridine (BUdR), have been prepared for electron microscopy. There is a positive correlation between light and electron mi... | 61,129 | [
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Effects of the liver homogenate obtained following partial hepatectomy on cirrhosis of the liver. | The authors studied the influence of liver homogenates as a whole and collected at various intervals after partial hepatectomy on cirrhosis of the liver. The lyophilized homogenates were administered over a period of 6 weeks to various groups of albino rats pretreated with CCl4 for a period of 6 months. The normal live... | 61,133 | [
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The chemical structure of capreomycin. | The chemical structure of capreomycin, antituberculous peptide antibiotic, was revised from the results of NMR-analysis in comparison with tuberactinomycins. Capreomycin IA and IB were concluded to possess the similar amino acid sequences in their cyclic peptide moieties to those of tuberactinomycins. | 61,134 | [
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[Rhinosporidiosis: clinical aspects, epidemiology and ultrastructural studies on Rhinosporidium seeberi]. | The author revises the main clinical aspect of the disease as well as its dignosis and its treatment. Rhinosporidium seeberi, first described by J.R. Seeber in 1900, then exhaustively investigated by J.H. Ashworth in 1923, has been accepted up to now as a phycomycete. Inside of the sporangial bodies, part of the polyp ... | 61,137 | [
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[New aspects and methods in gastroenterological diagnosis]. | Advances in the diagnosis of gastrointestinal diseases are achieved by development of new methods and by an improved analysis of the obtained data. New aspects of screening examinations for gastrointestinal cancer in high risk groups concern endoscopic-bioptic methods, the endoscopic retrograde cholangio-pancreaticogra... | 61,155 | [
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... |
Reverse plaque formation by hog cholera virus of the GPE-strain inducing heterologous interference. | A simple and rapid plaque procedure was developed for the assay of hog cholera virus (HCV) of a particular strain, GPE-, based on its intrinsic interference with vesicular stomatitis virus (VSV) on the primary swine testicle cells and on an established swine kidney cell line; the procedure is called the reverse plaque ... | 61,176 | [
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Results of virological and serological studies of three influenza A Hong-Kong epidemics in Leningrad. | An analysis of morbidity of the population in the course of 3 influenza A/Hong-Kong epidemics showed a pronounced decrease in influenza affection of adult population in the last epidemic in 1971--1972. Comparative studies of the diagnostic value of CFR and HIT demonstrated identical sensitivity of CFR as a method of in... | 61,243 | [
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Effect of cyproterone acetate on androgen-dependent synthesis of alpha2u globulin in rats. | Cyproterone acetate (CA, 2-5 mg/100 g body wt) inhibited androgenic induction of alpha2u globulin in spayed rats. In mature male rats, which normally produce alpha2u globulin, ten daily injections of CA did not inhibit synthesis of this protein. Long-term treatment of mature male rats (two injections every week for 12 ... | 61,248 | [
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... |
Recovery curves of the blink reflex during wakefulness and sleep. | The paired shock technique was used to study the effect of sleep on the excitability of the short latency R1 and long latency R2 components of the electrically elicited blink reflex. During wakefulness, R1 returned, after transient potentiation, to its original level in about 150 ms following the conditioning stimulus.... | 61,259 | [
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[Electric-sensoric examination and EEG to localize the focus of symptomatic epilepsy (author's transl)]. | Somatosensory cortical evoked potentials (SRAP) have been studied in normal subjects and in epileptic patients. The value of this method with regard to intracerebral localization was compared with the results obtained by EEG, scintigraphy, arteriography and surgical exploration. Contralateral evoked potentials were rec... | 61,261 | [
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Rat alpha-fetoprotein: isolation, radioimmunoassay and fetal-maternal distribution during pregnancy. | A method is described for the isolation of mg quantities of two forms of rat alpha-fetoprotein (AFP) from amniotic fluid by preparative disc-gel column electrophoresis using a continuous elution system. AFP isolated by this method is suitable for use as an antigen, can be labelled for use in a radioimmunoassay and serv... | 61,274 | [
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Mouse virulent strain of Staphylococcus epidermidis. Relation of antiphagocytic activity to the protection-inducing antigen. | Using 10(9) or 10(7) colony-forming units of a strain of Staphylococcus epidermidis (strain 1142) in saline or 5% mucin, respectively, 90 to 100% of mice died within 24 to 48 hr after intraperitoneal challenge infection. These organisms gradually multiplied in the peritoneal cavity when injected intraperitoneally into ... | 61,300 | [
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A suppressor T-cell defect in tropical splenomegaly syndrome. | Serum-IgM is always abnormally high in tropical splenomegaly syndrome. It is postulated that patients with this disease have an abnormal immunoglobulin response to malaria because they lack effective T suppressor cells. This defect may be genetically determined, thus explaining the tribal and familial aggregation of th... | 61,346 | [
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Rational choice of penicillins and cephalosporins based on parallel in-vitro and in-vivo tests. | Because of the unavailability of strictly comparable data, seven representative penicillins and the five cephalosporins currently used in Britain were evaluated in parallel, both in vitro and in vivo. Penicillin sensitive and resistant strains of Staphylococcus aureus and Proteus mirabilis were the main test organisms.... | 61,353 | [
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The management of stillbirth: coping with an unreality. | With about 1 stillbirth occurring in every 80 deliveries, stillbirth is a common tragedy. Yet it is an event which, by common consent, is cloaked in secrecy, and which by its very nature seems unreal. There are thus strong forces operating on the bereaved mother and her family, and on the professionals who care for the... | 61,354 | [
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"Anabolic" effects of methandienone in men undergoing athletic training. | After failure to confirm an anabolic action of testosterone and its derivatives in rats, methandienone ('Dianabol', an "anabolic steroid" used by athletes) has been given to 11 athletic men during a course of weight-training, in a double-blind, crossover experiment. The dose of methandienone was 100 mg/day for 6 wk. Bo... | 61,389 | [
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-0.01041079,
... |
Extra-amniotic prostaglandin E2 and the unfavourable cervix. | A small dose of prostaglandin E2 suspended in a viscous medium was instilled as a single application into the extra-amniotic space of patients with unfavourable induction features the day before planned induction in an attempt to improve the condition of the cervix. Two groups of 15 patients were studied, one receiving... | 61,394 | [
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0.0828047,
... |
HLA antigens and atopic features in steroid-responsive nephrotic syndrome of childhood. | Atopic systems were more common in children with steroid-responsive nephrotic syndrome (S.R.N.S.) than in matched controls, and HLA-B12 was more common in children with S.R.N.S. than in adult controls. Atopic symptoms (particularly hayfever), positive prick tests with grass pollen antigens, and a higher mean serum conc... | 61,442 | [
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An integrated view of the metabolic and genetic basis for obesity. | The propensity to obesity in animals and man identifies those individuals who are genetically favoured to survive when food supplies are scarce. Obese subjects are limited in their ability to produce heat, either in a cold environment or after food, because of a reduced activity in skeletal muscle of a "futile" cycle i... | 61,444 | [
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Amine metabolism and the small bowel in uraemia. | Intestinal intubation was carried out in 21 subjects: 9 with end-stage renal failure, 2 with early renal insufficiency, 7 untreated patients with blind-loop syndrome, and 3 normal volunteers. All 9 patients with uraemia had significantly raised duodenal dimethylamine (D.M.A.) concentrations compared with the other grou... | 61,496 | [
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Propranolol in the treatment of thyrotoxicosis: a review. | The clinical manifestations of hyperthyroidism have suggested to physicians for many years that the sympathetic nervous system may be involved in their production. Despite this, the precise interrelationship between the thyroid gland and the sympathetic nervous system has never been defined but controlled investigation... | 61,585 | [
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An RNA-dependent DNA polymerase, different from the known viral reverse transcriptases, in the chicken system. | The properties of an RNA-dependent DNA polymerase (an RNA-dependent DNA nucleotidyltransferase), which occurs ubiquitously in the allantoic fluid of uninfected, leukosis-virus-free eggs, are described. It is shown that the enzyme can synthesize faithful transcripts from natural RNA (globin mRNA). By biochemical and imm... | 61,587 | [
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... |
[Programmed typing in a school for the physically handicapped - testing a new audiovisual learning system (author's transl)]. | Within the framework of a test performed at a school for the physically handicapped, 10 pupils with disabilities varying in type and degree of severity completed a typing programme which was adapted to their individual physiological possibilities. The deliberate use of audiovisual media contributed both to an adaptatio... | 61,606 | [
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Effect of organ culture on the survival of thyroid allografts in mice. | Mouse thyroid can be maintained in organ culture for 4 weeks. Uncultured BALB/c thyroid is rejected 10-15 days after transplantation under the kidney capsule of H-2 disparate recipients (C57BL, CBA). Organ culture of thyroid tissue prior to transplantation prolongs allograft survival. This prolongation of graft surviva... | 61,634 | [
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Immunological enhancement of rat renal allografts using rabbit antisera with specificity for rat transplantation antigens. | Rabbits immunized with particulate and soluble preparations of rat lymphoid tissue of the HO strain produced antisera which reacted without strain specificity on rat lymphocytes. Absorption of the sera with tissue from the AS strain of rat removed the antibodies reacting with AS tissue leaving activity against HO cells... | 61,635 | [
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0.07703... |
Ultrastructural study on the meiotic prophase nucleus of rat oocytes. | Rat oocytes in the meiotic prophase are studied by means of classical techniques of electron microscopy, preferential staining methods for DNA and RNA and specific enzymatic hydrolysis. The axial cores in leptotene and the lateral arms in the pachytene synaptonemal complex are composed by fibrils that keep a positive c... | 61,697 | [
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0.08463497... |
Immunological cross reactivity of four enzymes involved in the biosynthetic pathway of lysine, methionine and threonine in Escherichia coli K12. | In Escherichia coli K12 the biosynthetic pathway of lysine, methionine and threonine is characterized by three isofunctional aspartokinases and two homoserine dehydrogenases. A single polypeptide chain carries the threonine-sensitive aspartokinase and homoserine dehydrogenase (AK I-HDH I), and a different polypeptide c... | 61,712 | [
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... |
Histological localization of nervous-system antigens in the cerebellum by immunoperoxidase labeling. | The indirect immunoperoxidase method was used to localize histologically on sagittal sections of mouse cerebellum antigenic determinants detected by the following antisera: anti-NS-2, anti-NS-3, anti-NS-4 rabbit anti-bovine corpus callosum, rabbit anti-mouse brain, rabbit anti-glial fibrillary acidic protein, and rabbi... | 61,794 | [
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... |
Gene activation of molecules with carcinoembryonic antigen determinants in fetal development and in adenocarcinoma of the colon. | "Fingerprints" of 0.9% NaCl solution extracts obtained from fetal guts and individual adenocarcinoma of the colon show a randomized pattern of expression of carcinoembryonic antigen (CEA) determinants by CEA radioimmunoassay and isoelectric focusing. All CEA-containing antigens found in a pool of 20 primary adenomas we... | 61,812 | [
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... |
Cell surface antigens. IV. Immunological coorespondence between glycophorin and the a1 human cell surface antigen. | A stable human-Chinese hamster ovary cell hybrid has been produced which, in addition to the complement of Chinese hamster ovary (CHO-K1) chromosomes, contains only one human chromosome, No. 11. The human cell-surface antigens whose expression is controlled by human chromosome 11, and are expressed by this hybrid, have... | 61,843 | [
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0.4750622,
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0.... |
Effect of Hoechst 33258 on Chinese hamster chromosomes. | Cells of the Chinese hamster strain C-125 were treated for different time intervals with H 33258, a bibenzimidazole derivative. The same compound was used to stain fixed cells of the same strain. H 33258 induced in cells in culture specific areas of reduced spiralization on the metaphase chromosomes of some cells. Thes... | 61,845 | [
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... |
Activity of neuronal populations of human subcortical structures during sleep. | Multi-unit activity of 14 subcortical structures was studied during drowsiness and sleep in patients with depth electrodes implanted in the brain for therapeutic purposes. The mean firing rate of the multi-unit activity was found to decrease during "slow-wave" sleep in each cycle. The multi-unit activity was sharply in... | 61,850 | [
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0.01190... |
Sleep patterns of the laboratory cat. | The effects of feeding schedule and external stimuli on sleep patterns were investigated in cats fed to maintain their mean body weight. The ECoG, EOG and EMG wer recorded from 3 male cats fed once daily and under a 12:12 light--dark schedule. The results for 15 working days were compared with those obtained at week-en... | 61,852 | [
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... |
Conditioned EEG desynchronization and seizure occurrence in patients. | Five patients with seizures poorly controlled by standard anticonvulsant medication, underwent EEG operant conditioning. The operant paradigm reinforced the production of low voltage fast activity while decreasing frequencies below 10 c/sec. Seizure frequency decreased in 2 patients, seizure severity was attenuated in ... | 61,854 | [
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Identification of the triploid genome by the C-banding method. | We report on cytogenetic studies of a malformed fetus, whose clinical symptoms indicated the diagnosis of triploidy. This was confirmed by chromosome analysis of peripheral lymphocytes of cord blood. Using the C-banding method it was possible to identify the origin of the extra haploid set: marker chromosomes indicate,... | 61,860 | [
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Deletion of hinge region of human myeloma IgG1 molecule (protein LEC) associated with nonexpression of G1m (3) and Km (1, 2) allotypes. A possible genetic explanation at the DNA level. | In this paper we report the structural basis for the nonexpression of G1m(3) and Km (1,2) allotypes in an IgG1 (kappa) human myeloma protein (protein LEC). Heavy and light chains spontaneously dissociate in sodium dodecyl sulfate polyacrylamide gels. Light chains appear to be covalently S-S bonded. Analysis of cysteine... | 61,877 | [
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... |
Effect of bilateral adrenalectomy and parenteral betamethasone on gastric mucosal mast cell population in albino rats. | The histamine-laden mast cells of gastric mucosa in albino rats are shown to degranulate on administration of Betamethasone, but they increase in number in adrenalectomized rats. It is concluded that Betamethasone, and also adrenal glucocorticoids increase gastric secretion by liberating histamine from mast cells and h... | 61,891 | [
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Experimental allergic encephalomyelitis: role of fibrin deposition in immunopathogenesis of inflammation in rats. | The immunopathogenesis of experimental allergic encephalomyelitis (EAE) is reviewed with special focus on the role of central nervous system fibrin deposition in the inflammatory cascade characterizing this autoimmune disease. Among rats sensitized to whole spinal cord or myelin basic protein of either guinea pig or bo... | 61,895 | [
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Effects of injury on the concentration of alpha1-macroglobulin and alpha2-macroglobulin in the plasmas of male and remale rats. | The effects of injury on the concentration of alpha1-macroglobulin and alpha2-macroglobulin in the plasmas of male and remale rats has been investigates. At 5 days after injury to the male rats the alpha1-macroglobulin concentration increased to 131% of its preinjury value. The alpha2-macroglobulin concentration increa... | 61,894 | [
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... |
A comparative study of the effects induced by MCN-A-343 and acetylcholine on the isolated toad rectus abdominis. | McN-A-343 (McN), a non nicotinic ganglionic stimulant, induced slow contractile responses of the toad rectus abdominis. A relaxation was also observed when large doses were added in the presence of a contraction caused by acetylcholine (Ach). The relaxation induced by McN could not be overcome by increasing Ach concent... | 61,902 | [
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... |
Practical approach to the diagnosis of sudden unexpected death of cardiac origin. | Experiences concerning the practical demonstration of recent myocardial lesion (infarction) with various conventional and enzyme-histochemical methods are explained. It has been found in our laboratory that besides careful inspection of the heart, additional useful information can be obtained with ordinary H-E staining... | 61,930 | [
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0.4323438,
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The use of non-deparaffinized tissue sections for staining leprosy bacilli. | Reduced acid-fast staining of leprosy bacilli occurs during the dewaxing of paraffin sections by xylene and alcohols; the older and more decrepit bacilli being especially affected. By the use of non-deparaffinized sections, the leprosy bacilli which could not be stained with the usual carbol fuchsin are strongly staine... | 61,950 | [
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-0.315809... |
[Alpha feto protein. Normal pregnancies and maternal diseases. Apropos of 3,010 radioimmunologic determinations]. | Using an immunological technique limits of normal levels of AFP in maternal blood have been worked out during pregnancy from a series of 3010 samples of blood. Comparing mean curves for the levels of AFP in mothers suffering from anaemia and diabetes with normal curves shows that there is a significant rise in these le... | 61,982 | [
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... |
Nucleoside specificity in the carrier IgG-dependent induction of tolerance. | Induction of tolerance to nucleoside haptens in BALB/c mice with isologous IgG conjugates bearing four nucleosides simultaneously (A, G, C, T)-IgG was confirmed. A mixture of separate nucleoside-IgG tolerogens (A-IgG, G-IgG, C-IgG, and T-IgG) was as effective or more effective that the (A, G, C,T)-IgG form in suppressi... | 61,997 | [
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0.08284274,
0.07450633,
0.1126103,
0.126872,
0.1260212,
0.2829033,
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-0.02674361,
-0.1132369,
0.2931454,
0.3733935,
-0.04735185,
-0.2870817,
... |
Tryptic cleavage of antibody binding sites from hepatitis B surface antigen particles. | The sedimentation of radiolabelled 22 nm hepatitis B surface antigen particles was unaffected by treatment with either trypsin or SDS alone, but combined treatment disrupted the particulate nature of the radiolabelled material. Considerable antibody binding activity by the group-specific determinant (a) was preserved a... | 62,023 | [
-0.06078805,
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0.2496136,
0.04208995,
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... |
Plasma membranes of muscle in experimental myotonia in rats. | Determinations of protein and phospholipid composition, as well as enzymatic activity, were carried out in plasma membranes isolated from the muscle of rats, after different periods of 20,25-diazacholesterol administration. A decrease in the level of phospholipids, and in the total amount of plasma membrane proteins, c... | 62,035 | [
-0.3217447,
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0.07057985,
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0.01972979,
-0.08920809,... |
Anatomical analysis of ventrolateral thalamic input to primate motor cortex. | 1. The origin and topographical organization of input to the arm area of the primate motor cortex from the ventrolateral thalamus were examined using the method of retrograde transport of horseradish peroxidase (HRP). 2. A thin, continuous slab of labeled neurons was found in the ventrolateral thalamus followingmultipl... | 62,039 | [
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0.... |
Comparison of graphical and computerized methods for calculating binding parameters for two strongly bound drugs to human serum albumin. | The determination of drug-protein binding parameters (n's and K's) can lead to important information on the required therapeutic dosage regimen and possible clinical complications associated with competitive displacement of one drug by a concurrently administered agent. Graphical and computer estimates of the data are ... | 62,049 | [
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Purification of the alpha subunit of avian myeloblastosis virus DNA polymerase by polyuridylic acid-sepharose. | The alpha subunit of the avian myeloblastosis virus DNA polymerase could be readily purified to near homogeneity using a polyuridylic acid-Sepharose column chromatography step. | 62,057 | [
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... |
New temperate bacteriophage for Bacillus subtilis, rho 11. | A new temperate bacteriophage, rho11, isolated by J. Hoch, has been characterized. This new phage is very similar to the temperate phage phi3T in size (380 nm), host range, homoimmunity, DNA buoyant density (1.694 g/ml), antigenicity, and molecular weight (around 6.0 X 10(7)) as determined in gels. Like phi3T, rho11 co... | 62,060 | [
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Radioisotope investigation of continuous bladder irrigation after transurethral resection. | Radioisotope studies using 131I serum albumin were performed on 20 patients to investigate the possibility of intravascular absorption of the irrigating solution during continuous bladder irrigation after transurethral resection of the prostate. In only 5 of 20 patients was a minimal absorption of 1 to 34 cc observed. ... | 62,061 | [
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0.0644078,
... |
Pneumocystis carinii pneumonia. Diagnosis by examination of pulmonary secretions. | To determine if examination of respiratory secretions is useful in diagnosing Pneumocystis carinii pneumonia, smear preparations of expectorated sputum, tracheal aspirates, and transtracheal aspirates stained by the Gomori methenamine silver nitrate method were examined. Pneumocysts were observed more frequently in mat... | 62,065 | [
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0.01603004,
0.2987852,
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0.3127585,... |
[Ventricular fibrillation and asystole precursors in myocardial infarct]. | Ventricular fibrillation and asystole are a frequent cause of death in myocardial infarction. The data of continuous monitoring the heart in 134 patients with acute myocardial infarction and ventricular fibrillation and asystole. The immediate precursors of ventricular fibrillation were predominantly ventricular extras... | 62,076 | [
-0.2406904,
0.1307845,
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0.2493933,
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0.03650016,
0.3283225,
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Experimental induction of hepatocellular hyalin (Mallory bodies) in mice by griseofulvin treatment. 1. Light microscopic observation. | Griseofulvin (GF) feeding of mice resulted in protoporphyria, liver cell damage, bile duct alterations, and finally hepatoma formation. In addition, hepatocellular hyalin developed, resembling in its morphology classic Mallory bodies (MB) as seen in alcoholic and nonalcoholic liver disorders in man. Liver cells contain... | 62,098 | [
-0.08281848,
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-0.04636817,
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0.01439081,
0.2620245,
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0.08819391,
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... |
Warfarin sodium in prevention of deep venous thrombosis and pulmonary embolism in patients with fractured neck of femur. | In a prospective controlled randomised trial, the prophylactic value of warfarin sodium (in doses aimed at maintaining a "Thrombotest" value of 10% and given from the day of admission until independent mobility had been achieved or for 3 mo, whichever was the sooner) was assessed in 160 elderly patients who had sustain... | 62,111 | [
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0.1887812,
0.04363032,
0.4545787,
0.1207494,
0.1512326,
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0... |
Active specific immunotherapy for ovarian cancer. | Ten patients with advanced or recurrent ovarian cancer were treated with a combination of chemotherapy and active specific immunotherapy after tumour stasis had been induced. They were inoculated with irradiated allogeneic cryopreserved tumour cells and B.C.G. once monthly in addition to receiving conventional chemothe... | 62,114 | [
-0.06526694,
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0.08209823,
0.3453675,
0.3086216,
0.4623634,
-0.201... |
Pathogenesis and phenotypes of an X-linked recessive lymphoproliferative syndrome. | A new X-linked recessive lymphoproliferative syndrome has variable phenotypes: fatal infectious mononucleosis (I.M.), agammaglobulinaemia after I.M., American Burkitt's lymphoma, histiocytic lymphoma, immunoblastic sarcoma of B cells, or plasmacytoma. An immunodeficiency to rubeola and the Epstein-Barr virus probably e... | 62,116 | [
-0.3133012,
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0.3168598,
0.09810803,
0.02215115,
0... |
Pulsatile blood-flow in arterial grafts. | The distensibility of arterial wall is an important factor in the haemodynamics of pulsatile blood-flow. Autogenous-vein grafts have a dynamic response to the arterial pressure pulse (compliance) which approaches that of normal arterial wall, whereas synthetic prostheses are generally incompliant, or become so shortly ... | 62,175 | [
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0.08213545,
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0.06588776,
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0.2155524,
0.3539549,
-0.1315272,
-0.07195063... |
Initial treatment of stage IIIA Hodgkin's disease. Comparison of radiotherapy with combined chemotherapy. British National Lymphoma Investigation. | 117 patients with stage IIIA Hodgkin's disease were randomly allocated for treatment in a multicentre trial comparing the results of total nodal irradiation (T.N.I.) with those of combination chemotherapy. Staging procedures for most patients included laparotomy; a few patients whose staging did not include laparotomy ... | 62,265 | [
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0.17782,
0.4999323,
0.3024105,
0.09467859,
0.4404485,
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0.... |
Antenatal diagnosis of neural tube defects. | One hundred women with pregnancies at risk for the recurrence of neural tube defects have entered our monitoring programme of echography and alphafetoprotein estimation (AFP) on amniotic fluid and maternal serum during the second trimester. The results of these pregnancies, the application of the programme, sources of ... | 62,270 | [
-0.1981837,
-0.1983292,
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0.3740279,
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0.06908186,
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0.2196899,
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0.09040234,
0.09754395,
0.09427474,
-0.09069745,... |
Stepwise biosynthesis in vitro of globin genes from globin mRNA by DNA polymerase of avian myeloblastosis virus. | Two approaches have been explored for the synthesis of double-stranded DNA from single-stranded DNA template complementary to rabbit 9S globin mRNA (cDNA). (i) cDNA was elongated with dCMP or dTMP homopolymeric tracts using terminal deoxynucleotidyltransferase (EC 2.7.7.31; nucleosidetriphosphate:DNA deoxynucleotidylex... | 62,360 | [
-0.3532726,
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0.2084781,
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0.3809071,
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-0.4676628,
-0.0475386,
-0.0937461,
0.3212683,
0.5839525,
-0.0480237,
-0.2207763... |
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