title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Arthritis related to intestinal anastomoses]. | Jejuno-colic and jejuno-ileal anastomoses may provoke arthritis. The recently recognized physiopathology is that of arthritis due to immune complexes related to pullulation of Escherichia coli and of Bacilus fragilis. These cases of arthritis, usually sensitive to therapy, have, in some stutborn cases, required the re-... | 62,379 | [
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Subpopulations of human lymphoblastoid cell lines. Correlation with the expression of surface receptors and content of Epstein-Barr virus genome. | Forty lymphoblast cell lines derived from normal subjects, patients with infectious mononucleosis, leukemia, and Burkitt's lymphoma have been studied for surface receptors including surface Ig, complement receptors by the EAC rosette and fluorescent (Raji cell) techniques, and Fc (aggregate) receptor by direct and indi... | 62,390 | [
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The role of radionuclides in clinical oncology. | The major role of radionuclides in clinical oncology is, in the broadest sense, "tumor scanning". This includes evaluating specific organs for the presence of tumor (usually with different radiopharmaceuticals for each organ) or the entire body (generalized tumor searches with radiopharmaceuticals with 67Ga-citrate or ... | 62,399 | [
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Plasmin inactivation in plasma. | Inhibition and inactivation of plasmin is ascribed to alpha2-macroglobulin, alpha1-antitrypsin and c1-esterase inhibitor. In an "overall" inactivation test of plasmin in plasma, which comes perhaps closest to rapid inactivation of plasmin in the circulating blood, we only found a correlation between the immunological c... | 62,411 | [
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[Palliative surgery in bronchial carcinoma and surgery for metastases (author's transl)]. | Report on 54 patients with bronchial carcinoma, where a primary palliative resection of the tumor has to be done. Indications were central abscess of the carcinoma, bleeding of the tumor by arrosion, pain because of infiltration of chestwall, patient's demand on operation. Beneath lobectomy and pneumonectomy parietal p... | 62,412 | [
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Eight groups of human endothelial cell alloantigens. | Human endothelial cells were shown to express a new system of alloantigens. Using 63 selected sera eight specificities could be defined. Each group was characterized using two to seven sera which had high correlation coefficients among them. The distribution of the phenotypes among 30 cells gave the appearance of an al... | 62,419 | [
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Acid-fastness of Mycobacteri,m tuberculosis H37Rv following infection by mycobacteriophage DS6A. | Mycobacterium tuberculosis H37Rv demonstrates a loss of acid-fastness following exposure to specific mycobacteriophage DS6A. No effect was seen with another mycobacteriophage GS7 which does not lyse this organism. | 62,438 | [
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[Liver function tests under the influence of sequential treatment using ethinyl estradiol-norethisterone acetate and ethinyl estradiol-chlormadinone acetate]. | 30 young healthy women were investigated during the first therapy cycle with ethinyl-estradiol-norethisterone acetate and ethinyl-estradiol-chlormadinone acetate as a sequential regime. The following laboratory data were achieved by each of the investigated group of young women: serum aminotransferase (GOT and GPT), se... | 62,469 | [
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Species-common antigen of connective tissues. | Collagen-free extracts were prepared from bovine, porcine and canine hyaline, elastic and fibrous cartilages, articular capsule, tendon, aorta, cortical bone and regenerating articular surfaces. The extracts were investigated with antisera to bovine nasal septal cartilage, dog articular cartilage and non-collagenous pr... | 62,479 | [
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In vitro uptake of 5-hydroxytryptamine and dopamine by rat mast cells after exocytosis induced by antigen or compound 48/80. | Mast cells from the peritoneal and pleural cavities of actively sensitized rats were isolated and incubated with biogenic amines (5-hydroxytryptamine and dopamine) with or without pretreatment with specific antigen. An anaphylactic reaction resulting in the release of 20-25% of the histamine in the cells led to a sligh... | 62,489 | [
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Effect of polyamines on yeast cell-free protein synthesizing system. II. Increase stability of cell-free system in the presence of spermine. | The addition of spermine, at concentration which stimulates protein synthesis, to the yeast cell-free system significantly increases the thermal stability of the latter. Similar stabilizing effect of polyamine is observed for ribosome-poly U-ac-phe-tRNA complexes. These results suggest that the stimulatory effect of po... | 62,495 | [
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Determination of growth of aquatic bacteria by measurements of incorporation of tritiated thymidine. | Evaluation was made of a novel technique, combining semi-continuous culture on membrane filters and assessment of the incorporation of titrated thymidine. The optimal temperature of incubation is 20--25 degrees, the period of incubation--3 hours; the initial activity of tritiated thymidine--0.5 muC/ml. There is a linea... | 62,505 | [
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The depletion of the granules of argentaffin and argyrophile cells of monkey duodenum by reserpine. | The influence of reserpine (5 mg/kg) on the argentaffin and argyrophile cells has been studied in 4 monkeys, and in 4 controls. In the treated animals, there is a marked and obvious reduction in the number of argentaffin cells; the cells that remain also show signs of partial depletion. Reduction of the number of argyr... | 62,522 | [
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Antihistamines. Guidelines and implications. | Antihistamines may be used to maximum benefit for the allergic patient if the physician adheres to four guidelines. These guidelines are based upon 1) an appreciation of certain structural and pharmacologic differences among antihistamines, and 2) an understanding of their mechanism of action. Around the clock administ... | 62,547 | [
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Type C oncornavirus isolation studies in systemic lupus erythematosus. I. Attempted detection by isopycnic sedimentation of 3H-uridine-labelled virions. | Type C oncornavirus isolation was attempted from cell cultures of tissues from 7 patients with systemic lupus erythematosus. Detection was based on the characteristic sedimentation of 3H-uridine-labelled virions at a density of 1-16 g/ml. Cultures positive by this method were negative by two other criteria for type C v... | 62,558 | [
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Herpetic corneal epithelial disease. | The clinical differentiation of corneal epithelial lesions due to herpes simplex or herpes zoster may be confusing. Practical clinical tests, including the use of topical ocular stains, are useful to differentiate corneal epithelial lesions caused by these two viruses. Two distinctive types of zoster corneal epithelial... | 62,568 | [
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Terminal deoxynucleotidyl transferase measurements in the differential diagnosis of adult leukaemias. | Terminal deoxynucleotidyl transferase (TDT) is an unusual DNA polymerase that does not use template information to synthesize new strands of DNA. It is normally found in high concentration in thymus (50 u/10(8) cells) and in low concentration in bone marrow (less than 5 u/10(8)). We report TDT measurements in the marro... | 62,584 | [
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Studies on J chain and binding site for secretory component in circulating human B cells. II. The cytoplasm. | About 0-3-1-1% of the lymphoid cells from peripheral blood of healthy adults contained cytoplasmic immunoglobulin (Ig). The class distribution of these B cells varied greatly among individuals, with a preponderance of the IgA (26-65%) or the IgG (15-66%) class. A remarkably high percentage of the Ig-containing cells we... | 62,631 | [
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Studies on the pathogenesis of enteric infections caused by invasive bacteria. | Salmonellae, shigellae and some Escherichia coli must invade the intestinal epithelial cell and multiply within the mucosa to cause disease. Although the bacterial cell most likely possesses several properties essential to this invasive ability, the nature of the cell envelope complex is at present the only characteris... | 62,646 | [
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Automated sleep EEG analysis applied to the evaluation of drugs: illustration by study of clorazepate dipotassium. | An automated sleep EEG analysis system was used to evaluate the effects of clorazepate dipotassium in normal subjects. Ten young-adult men slept 18 consecutive nights in the laboratory. On days 8-15 clorazepate (7.5 mg) was administered three times daily; on days 5-7 and 16-18 a placebo was administered in a similar fa... | 62,653 | [
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Correlation between confirmed sites of neurological lesions and abnormalities of far-field auditory brainstem responses. | Far-field auditory brainstem responses were recorded in ten patients in whom the distribution of pathology was defined at autopsy or at operation. The response normally consists of seven components in the initial 10 msec following click signals. Interruption of audiotory pathway at the junction of VII nerve with brains... | 62,654 | [
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Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone. | The anti-PC antibodies of BALB/c origin bear predominantly the idiotype characteristic of the phosphorylcholine (PC)-binding T15 idiotype than sera from adult mice, and, unlike the latter, they also contain detectable amounts of anti-T15 antibodies. By 2 weeks of age the anti-T15 antibodies are no longer detectable whi... | 62,670 | [
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Serum alpha-fetoprotein as a marker for the effect of post-operative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumour. | The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological exmination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, e... | 62,720 | [
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Fluorescent antibody localization of myosin in the cytoplasm, cleavage furrow, and mitotic spindle of human cells. | We have studied the distribution of myosin molecules in human cells using myosin-specific antibody coupled with fluorescent dyes. Rabbits were immunized with platelet myosin or myosin rod. They produced antisera which precipitated only myosin among all the components in crude platelet extracts. From these antisera we i... | 62,755 | [
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Effect of megestrol acetate (Megace) on steroid metabolism and steroid-protein binding in the human prostate. | Megestrol acetate (Megace), an antiandrogen, was administered in a dosage of 80 mg daily to 6 patients with benign prostatic hypertrophy (BPH) for 4 to 25 days prior to transurethral resection of the prostate (TURP). Surgical tissue from drug-treated patients was compared to untreated controls in regard to: 1) the enzy... | 62,759 | [
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Assessment of group B streptococcal opsonins in human and rabbit serum by neutrophil chemiluminescence. | The factors important in host defense against group B streptococci are not well understood. The role of antibody and complement in the prevention of serious infection by these organisms is not known because, to date, a reliable measure of functional opsonic activity has not been developed. Recently, it has been shown t... | 62,761 | [
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Use of food colourants as plaque disclosing agents. | The effectiveness of plaque disclosure by several liquid food colourants and disclosing agents was compared in a group of eight subjects. The subjects refrained from all forms of oral hygiene for a 48-hour period prior to rinsing with 5 ml of each dye in turn at weekly intervals. Kodachrome film records were taken and ... | 62,762 | [
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Antigen-specific and nonspecific mediators of T cell/B cell cooperation. IV. Development of a model system demonstrating responsiveness of two T cell functions to HGG in vitro. | Previous work in this laboratory has defined two functionally distinct T cell subpopulations (viz., antigen-specific helper) and characerized some of the parameters of these subpopulations derived from the keyhole limpet hemocyanin (KLH)-primed mouse spleen. Characerization of further parameters such as relative suscep... | 62,797 | [
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0.4139254,
0.2298456,
0.258197,
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0.3176737,
0.07390427,
0.402554,
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-0.1379294,
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0.2106551,
0.1121762,
-0.02548555,
-0... |
Lipid storage myopathies. A review of metabolic defect and of treatment. | Various cases of lipid storage myopathies have been described. The biochemical defect could be determined in only some of these cases. The syndromes identified to date are as follows: carnitine deficiency (type I lipid storage myopathy), carnitine-palmityltransferase (CPT) deficiency and pyruvate-decarboxylase deficien... | 62,824 | [
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-... |
[Demonstration of a factor in cerebrospinal fluid with inhibitory activity for electrophoretic cell mobility in multiple sclerosis (author's transl)]. | Inhibition of electrophoretic cell migration using cerebrospinal fluid (CSF) directly was investigated by the modified MEM (macrophage electrophoretic mobility) and TEEM (tanned sheep erythrocyte electrophoretic mobility) tests, respectively. An inhibitory activity of macrophage slowing factor (MSF)--one of in vivo lym... | 62,827 | [
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0.3849163,
0.1348925,
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-0.14231... |
Muscle enzymatic changes induced by blockage of axoplasmic transport. | The activity of malic dehydrogenase, pyruvic kinase, and phosphorylase b was measured in the geniohyoid muscle of the cat after injection of 10 10 mM colchicine into the hypoglossal nerve. Experiments performed 1-60 days after the injection showed that the activity of the three enzymes gradually decreased (day 4-5), re... | 62,830 | [
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0.0133706,
0... |
Differential transmission in the superior cervical ganglion of the cat. | Mechanisms in the superior cervical ganglion resulting in contraction of the nictitating membrane (NM) and dilation of the parasympathectimized pupil were studies in anesthetized cats. Frequency-response curves were obtained following pregangionic stimulation with NM and pupillary responses recorded simultaneously in ... | 62,832 | [
-0.2037744,
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0.1821441,
0.08979699,
... |
Evidence for prevention of borderline leprosy reactions by dapsone. | 68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups... | 62,998 | [
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Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid. | Thirteen patients with keratinising dermatoses were treated for 2-17 weeks with oral 13-cis retinoic acid. There was near complete clearing of the skin lesions beginning within 2 weeks of starting treatment in all five patients with lamellar ichthyosis (including two cases of non-bullous congenital ichthyosiform erythr... | 62,999 | [
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0.06503244,
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0.2840717,
0.2607535,
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The primary enzyme defect in hereditary coproporphyria. | The activity of coproporphyrinogen oxidase (E.C. 1.3.3.3) in cultured skin fibroblasts from three patients with hereditary coproporphyria (H.C.) was approximately half that in fibroblasts from normal subjects and patients with other types of porphyria. It is suggested that this is the primary defect in H.C., which is i... | 63,041 | [
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0.1076216,
0.2226284,
0.376349,
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0.03... |
Where do all the tablets go? | Barium sulphate tablets, identical in size and shape to those of aspirin, were given to 98 consecutive patients during routine radiological studies of the upper gastrointestinal tract. In 57 patients the tablets remained in the oesophagus for longer than five minutes. Delay in passage of the tablets was particularly li... | 63,055 | [
-0.0599557,
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0.03484759,
0.1... |
Differential localisation of substance P and motilin. | Motilin, and Substance P, have previously been shown to be present in enterochromaffin (EC) cells in the gut mucosa. By comparing a specific immunofluorescence stain for Substance P with an immunoperoxidase reaction for motilin, applied sequentially to the same tissue section, it is possible to demonstrate that the two... | 63,140 | [
-0.2139337,
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0.2068716,
0.2597041,
0.1900126,
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-... |
[Diagnostic laparotomy and palliative surgery in jaundice caused by tumors of the pancreato-duodenal zone]. | The remote results of palliative operations for tumors of the pancreatoduodenal zone in 266 patients were analysed. Among palliative procedures cholecysto-jejunoanastomosis was most frequently employed in the clinic. 72 patients died. An acute hepatic insufficiency and cancerous intoxication was the main cause of the m... | 63,175 | [
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0.1349542,
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0.5087392,
0.2878238,
-0.1815753... |
[Air pollution by motor vehicles along the freeways]. | Total mass particulates and benzopyrenes have been determined to evaluate the specific pollution by vehicles on a section (6 km) of a highway. The traffic density generated an increase of 30% mass particulates in nighttime and 44% during daylight. Concentrations of benzopyrenes in air have doubled compared to the perio... | 63,193 | [
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0.1883505,
0.09134953,
0.2543735,
0.1357531,
0.1085832,
... |
Oat-cell bronchial carcinoma. Identification of cells in pleural fluid. | An analysis is made of the accuracy of diagnosing oat-cell (small cell) carcinoma of the lung from the cytology of pleural fluid. All the material over a 22-year period has been reviewed. Air-dried smears were used, stained with May-Grünwald-Giemsa. Of 91 cases in which oat-cells were specified in the written report, 9... | 63,205 | [
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0.4278046,
0.17955,
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... |
Five new Escherichia coli K antigens, K95, K96, K97, K98 and K100. | Five Escherichia coli strains were established as antigenic test strains for five new polysaccharide K antigens: K95, K96, K97, K98 and K100. K95 to K98 served already as test strains of O antigens O75, O77, O81 and O107 respectively. F147, which is test strain of K100, had O antigen O75. | 63,221 | [
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0.213935,
0.1289012,
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0... |
The impact of HLA-A, B or HLA-D identity on the MIF production in MLC. | The relative influence on MIF release in MLC of different parts of the HLA region was studied in 1) MLCs between cells from HLA-A and B identical (probably HLA-D unidentical) unrelated persons and 2) MLCs between cells from HLA-D identical, HLA-A and B unidentical unrelated persons. It was found that the HLA-D part of ... | 63,222 | [
-0.09719095,
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0.1061839,
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0.4031463,
0.4468609,
0.09119917,
-0.1864... |
Antigenic properties of a DNA-preparation from calf thymus used for the demonstration of anti-DNA. | It was attempted to evaluate passive haemagglutination of antigen coated, tanned erythrocytes as a test by which to demonstrate anti-DNA in systemic lupus erythematosus. The antigens was prepared using a minimum of procedures in order to produce a native preparation. The resulting material had most of the criteria appl... | 63,225 | [
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0.1239833,
0.3576615,
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0.378... |
Radioimmunoassays for prostaglandin metabolites. | Radioimmunoassays were developed for the main plasma and urinary metabolites of PGF2alpha in the human, viz., 15-keto-13,14-dihydro-PGF2alpha and 5alpha, 7alpha-dihydroxy-11-ketotetranorprosta-1,16-dioic acid. The methods allowed assay of unextracted samples and had a sensitivity of 5 pg and 2 pg, respectively. The ass... | 63,236 | [
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0.2459386,
0.2678715,
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Studies on the characteristics of poliovirus type 3. II. Characteristics of "hot" clones. | Markers d, IST, EA1(OH)3, rct (at sub- and supraoptimal temperatures) and neurovirulence were determined for clones isolated from two lots (S2 and S3) of vaccines containing poliovirus strain Leon 12a1b. Changes of markers rct, d and neurovirulence were observed in several clones isolated from S2 vaccine. No changes we... | 63,237 | [
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0.548609,
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A light microscopic, autoradiographic study of axoplasmic transport in the optic nerve head during ocular hypotony, increased intraocular pressure, and papilledema. | Cyclocryotherapy of the monkey eye reliably produces transient increased intraocular pressure followed by prolonged hypotony, during which papilledema occurs. Axoplasmic transport was studied while the intraocular pressure was both increased and decreased after cyclocryotherapy by autoradiography following the intravit... | 63,246 | [
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0.1240522,
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Removal of blood group determinants from bovine erythrocyte membranes. 3. Action of proteolytic enzymes on intact cells. | Bovine erythrocyte treatment with chymotrypsin, trypsin, pronase, papain, or ficin eliminated or weakened the reactivity of 18 of the 47 blood group factors which were examined. Thirteen of the affected factors were from the B system, and one each was from the C, FV, L, M, and R'S' systems. Variation attributable to ph... | 63,256 | [
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0.1120172,
0.299881,
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-0.015475... |
Histological characteristics of chronic hepatides and primary biliary cirrhosis with special reference to orcein positive hepatocellular accumulations. | The histological criteria of chronic hepatides (chronic persistent and aggressive hepatitis) and primary biliary cirrhosis are well characterized and documented in the literature. Histology forms the diagnostic basis for chronic hepatides. Diagnostic changes are seen, however, only in some cases of primary biliary cirr... | 63,264 | [
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0.08494111,
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0.3142402,
0.1496958,
0.1763649,
0.08637581,
0.281... |
The prevention of viral hepatitis. | Studies with heat-inactivated MS-2 serum have indicated that active immunization against hepatitis B infection can be achieved even though the virus has not been cultivated in tissue culture. The development of new biophysical, biochemical and immunological techniques has increased knowledge of the hepatitis B virus an... | 63,266 | [
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... |
Palliation of infants with truncus arteriosus through creation of a pulmonary artery ostial stenosis. | A surgical procedure for palliation of infants with truncus arteriosus and excessive pulmonary blood flow (types I, II, and III) is described. The technique involves the production of ostial stenosis of the pulmonary artery from within the truncus using cardiopulmonary bypass. This method has advantages over pulmonary ... | 63,271 | [
0.001396994,
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0.3190428,
0.05770589,
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... |
Density of mucous glands in the normal adult nasal septum. | The entire mucosa from 13 normal nasal septa was stained by the PAS-alcian blue whole-mount method, and the mean density of glandular orifices in 13 localities was determined quantitatively by counts in 4 mm2 fields. The median density within the entire material was 8.4 glands/mm2, with an interindividual variation of ... | 63,279 | [
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0.04964635,
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0.2852343,
0.03704673,
-0.039415... |
Antibody-like activity to polyacrylic acid in normal rabbit sera. | Most unimmunized rabbit sera agglutinate acrylic particles coated with polyacrylic acid. The factor responsible for the agglutinating activity turned out to be a 2-mercaptoethanol-resistent immunoglobulin, present in low concentration. It was tentatively classified as "natural antibody". This is assumed to have arisen ... | 63,297 | [
-0.08402786,
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0.2992248,
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-0.13... |
Common tumor rejection antigens in methylcholanthrene-induced squamous cell carcinomas of mice detected by tumor protection and a radioisotopic footpad assay. | Seven transplantable lines of squamous cell carcinoma of the skin initiated in BALB/c mice by skin painting with methycholanthrene were systematically tested for cross-reactivity of their tumor rejection antigens in a 7 X 7 matrix. As determined by decreased tumor frequency after tumor cell challenge, each line was imm... | 63,329 | [
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0.7294382,
0.3363367,
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... |
Separation of primary and secondary cardiovascular events in systemic anaphylaxis. | The purpose of this investigation was to differentiate primary cardiac participation in systemic anaphylaxis from a cardiac reaction secondary to respiratory distress. Hemocyaninsensitized guinea pigs were anesthetized with sodium pentobarbital and artifically ventilated. The chest was opened and the left ventricle can... | 63,338 | [
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0.1863456,
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0.2037089,
-0.2696... |
alpha1-Antichymotrypsin interaction with cationic proteins from granulocytes. | Human granulocytes contain cationic proteins with chymotrypsin-like activity. These proteases showed a higher relative affinity for alpha1-antichymotrypsin than for alpha1-antitrypsin but the highest affinity for alpha2-macroglobulin. The complexes between cationic protein and alpha1-antichymotrypsin migrate as beta-gl... | 63,339 | [
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-0.005636372,
-0.... |
Preliminary amino acid sequences of transplantation antigens: genetic and evolutionary implications. | Preliminary amino acid sequence data on the transplantation antigens of mouse and man have led to provocative hypotheses about the genetic organization and evolution of genes coded by the major histocompatibility complex of mammals. New microsequencing techniques should permit a detailed analysis of these gene products... | 63,354 | [
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... |
Characterization of Drosophila heterochromatin. II. C- and N-banding. | The C- and N-banding patterns of D. melanogaster, D. simulans, D. virilis, D. texana, D. ezoana and D. hydei were studied in comparison with quinacrine and Hoechst banding patterns. In all these Drosophila species the C bands correspond to the heterochromatin as revealed by the positive heteropycnosis in the prometapha... | 63,359 | [
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... |
Nature of cross-reaction between hCG and anti-oLH serum and development of a radioimmunoassay to measure hLH specifically in the presence of hCG. | Immunological cross-reaction between hCG and anti-oLH sera has been demonstrated using radioimmunoassay techniques. The results indicate that this cross-reaction is incomplete and that the anti-oLH sera used have the ability to distinguish between LH and hCG. Following absorption with purified hCG, anti-oLH serum was u... | 63,368 | [
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... |
Morphological types of hepatocellular hyalin in Indian childhood cirrhosis: an ultrastructural study. | Morphological variants of intrahepatocytic hyalin in Indian childhood cirrhosis have been analysed by electron microscopy. This structure, morphologically identical with Mallory's alcoholic hyalin, is encountered in three different forms. The most common one is composed of randomly oriented fibrils. The next common typ... | 63,414 | [
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An improved technique for selective silver staining of nucleolar organizer regions in human chromosomes. | A reliable technique for staining human chromosomal nucleolar organizers (NOR's) with silver solutions is described. The NOR's can be selectively stained dark brown by silver solutions leaving the chromosome arms unstained and available for counterstaining with orcein or Giemsa dyes. Unequivocal identification of chrom... | 63,440 | [
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0.17... |
Segmentation of human chromosomes induced by 5-ACR (5-azacytidine). | The 5-ACR (5-azacytidine) introduced in human lymphocyte cultures induces a lack or a delay of condensation of some chromosome segments corresponding to the G-bands. The resulting R-banding is very similar to that obtained with a 7-h treatment by BrdU, although the segmentation may be much stronger (pulverization) with... | 63,442 | [
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0.3806039,
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Influence of Q- and G-banding on the Feulgen-stainability of human metaphase chromosomes. | In this paper, model experiments on chicken red blood cell nuclei are described concerning the influence of methanol-acetic acid fixation and irradiation at different wavelengths, with and without prior Atebrin staining on subsequent Feulgen-stainability. In addition, data are reported on the influence on Feulgen-stain... | 63,454 | [
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... |
Light-induced exchange of nucleotides into coupling factor 1 in spinach chloroplast thylakoids. | The method of centrifugation of chloroplast thylakoids through silicone fluid, previously used to estimate the uptake of solutes by thylakoids, is shown to be an excellent method for measuring binding of nucleotides to thylakoids. This binding, which is probably an exchange (Harris, D. A. and Slater, E. C. (1975) Bioch... | 63,460 | [
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... |
Delta5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal men and women. | Using the constant fusion and single injection technique the metabolic clearance rates (mean +/- SEM) for delta5-androstene-3beta, 17beta-diol (delta5-idol) were measured for 19 normal men (1311 +/- 67 1/24 h) and 10 normal women (858 +/- 63 1/24 h). The constant infusion technique yielded values for the conversation r... | 63,469 | [
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... |
The specificity of cellular immune responses II. The structure of antigenic determinants leading to T-lymphocyte stimulation. | T cells from guinea pigs immunized with the hapten 2,4-dinitrophenyl (DNP)-coupled directly to mycobacteria are of interest since they recognize and respond to DNP conjugated to many but not all carriers. The experiments reported here further analyze the structure of the complex, chemically defined antigenic determinan... | 63,530 | [
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Qualitative patterns of protein synthesis in the mouse oocyte. | Mouse oocytes were found to synthesize proteins actively at the germinal vesicle, metaphase I, metaphase II, and pronuclear (6 hours post-fertilization) stages. The qualitative pattern components being synthesized in vitro, as demonstrated using polyacrylamide gel electrophoresis, changed throughout maturation and fert... | 63,535 | [
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Xenotropic properties of an isolate from murine Rauscher leukemia virus in primates. | Murine Rauscher leukemia virus (MuRLV) from BALB/c plasma consisting of a mixture of an ecotropic and a xenotropic virus could be separated out by a selection process when propagated in human and simian cell cultures. This hypothesis is supported by obtaining consistently lower infectivity titers of human cell propagat... | 63,554 | [
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Interaction analysis of selective and nonselective cell-mediated cytotoxicity. | The coexistence of selective and nonselective cytotoxic cells in effector suspensions required a method of separating the two effects before specificities in cell-mediated cytotoxicity could be investigated. A method of analysis was derived which used the average cytotoxicity for each effector and target to estimate se... | 63,558 | [
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Combined cystometric, sphincter electromyographic and uroflowmetric studies before and after transurethral resection of the prostate. | Detrusor and urethral function was studied in 10 patients before and 3 months after transurethral resection of the prostate by means of flowmetry, and simultaneous gas cystometry and integrated sphincter electromyography. THE PATIENTas cystometry and integrated sphincter electromyography. The patient had no clinical s... | 63,571 | [
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0.3098563,... |
Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial. | 40 adult outpatients with active endoscopically proven duodenal ulceration, who would otherwise have merited elective ulcer surgery, entered a double-blind trial of either cimetidine (1g/day) or placebo. After twenty-eight days, 17 of 20 (85%) patients receiving cimetidine showed ulcer healing, compared with 5 of 20 pa... | 63,673 | [
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-0.114520... |
Plasma-exchange and immunosuppression in the treatment of fulminating immune-complex crescentic nephritis. | Nine patients with fulminating immune-complex crescentic nephritis were treated by a regimen of intensive plasma-exchange, steroids, and cytotoxic drugs. In five patients with severe renal failure there was early and rapid improvement in renal function; in one patient an early but extensive focal necrotising glomerulit... | 63,710 | [
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... |
Evidence that endogenous calcitonin protects against renal bone disease. | Plasma concentrations of calcium, phosphate, alkaline phosphatase (A.P.), immunoreactive calcitonin (iC.T.), and immunoreactive parathyroid hormone (iP.T.H.) were measured in fifty-two patients with chronic renal failure on maintenance haemodialysis. On the basis of a bimodal distribution of values for plasma-A.P. the ... | 63,802 | [
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0.102068,
0.271199,
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0.0537... |
Amniography for the early detection of neural tube defects. | Among the methods available for the midtrimester diagnosis of neural tube defects, it has been suggested that amniography be used to determine the presence of meningomyelocele. Twelve studies are reported in which the procedure was utilized. In 3 cases, a neural tube defect was present but was not detected by this meth... | 63,927 | [
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Silver deposition in mouse glomeruli. | Administration of 6 mM silver nitrate in the drinking water of mice resulted in deposition within the glomerular basement membrane of silver granules which were detected on electron microscopy after 12 days. Larger aggregates were detected in the basement membrane and mesangium when silver ingestion was extended to 14 ... | 63,934 | [
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Binding of triton X-100 to diphtheria toxin, crossreacting material 45, and their fragments. | Binding of the nonionic detergent [3H]Triton X-100 by diphtheria toxin, by the nontoxic serologically related protein crossreacting material (CRM) 45, and by their respective A and B fragments has been studied. If first denatured in 0.1% sodium dodecyl sulfate, all of the proteins with the exception of fragment A bind ... | 63,947 | [
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0.016... |
Immunological crossreaction between alpha-fetoprotein and albumin. | Alpha-fetoprotein (AFP), a fetal protein associated with certain tumors, and serum albumin did not corssreact immunologically in native form. Unfolding of their polypeptide chains by reduction of the disulfide bonds followed by carboxamidomethylation produced derivatives with immunochemical properties different from th... | 63,951 | [
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[Diagnostic methods in drug allergies]. | Immunological exploration of a patient following an allergic complication is based on tests in vitro, which are free of danger. At the present time it remains very difficult, on the one hand on the basis of the antigenic radicle responsible, secondly because of the characteristics of the immune response which it induce... | 63,984 | [
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... |
Sterilized hepatitis B (surface) antigen for production of specific antisera. | The combined treatment with beta-propiolactone and ultraviolet rays described for the sterilization of HBsAg-positive sera does not interfere with the purification procedures for the production of HBs antigen. The immunogenicity of the HBs antigen is retained. | 64,018 | [
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0.... |
[Cellular immunity responses in studies of the specificity of leukocyte hepatitis virus]. | Hypersensitivity of a delayed type to leukocyte hepatitis virus (LHV) was established in patients with virus hepatitis. The results of the skin tests with the LHV antigen were positive in 15 out of 20 patients with active chronic hepatitis, in 17 out of 20 convalescents and in 3 out of 20 patients in the acute stage of... | 64,028 | [
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[Epidemiological and laboratory criteria in the assessment of meningococcus carrier state]. | A study was made of the duration of meningococcus carrier state, immunological indices and group-specific properties of meningococci isolated from them. The periods of meningococcus discharge were studied in 738 persons. Three categories of the carrier state were revealed: a single discharge (67% of the carriers), of a... | 64,094 | [
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0.4773073,
0.1333352,
0.1578153,... |
[The effect of homologous gamma-globulin on nonspecific factors of antiviral immunity in prophylactic and therapeutic application]. | Administration of homologous gamma-globulin for prophylactic purpose promoted an increase in the interferon-synthesizing activity of leukocytes. The therapeutic use of this preparation in tick-borne encephalitis produced no stimulating effect on this index. | 64,096 | [
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Comparative studies of the incorporation inhibition of radioactive nucleotides and amino acids in vitro under the influence of adriamycin, bleomycin, and sodium arsenate. | The incorporation of 14C-marked nucleotides and amino acids into the nucleic acids and into the cellular protein of PHA-stimulated human lymphocytes was inhibited variably by increasing doses of Adriamycin, Bleomycin and Na2HAsO4. The findings, which were obtained with the aid of the liquid scintillation counter and pa... | 64,130 | [
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The role of IgE in the immune response to neoplasia: a review. | The role of IgE in the immune response to neoplasia has received little attention despite suggestive evidence for an IgE response to tumor specific antigens. A complex interrelationship is known to exist between basophils, eosinophils, histamine, complement, and T cells. The latter cells are known to play a central rol... | 64,292 | [
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0.1045693,
0.1961751,
0.071061,
-0.01746104,
0.2133132,
-0.1983113... |
Treatment of cancer of the ovary. | This chapter has stressed the importance of early diagnosis in the treatment of cancer of the ovary with suggestions as to achieving this goal by a more aggressive approach to the accurate diagnosis of pelvic tumours. The combined use of surgery with radiation therapy and/or chemotherapy has also been discussed with th... | 64,330 | [
0.1190301,
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... |
Treatment of cystic ovarian disease in dairy cattle. Comparative observation of the effects of an intramuscular injection of corticosteroids and an intravenous injection of a combination of human chorionic gonadotropin and progesterone. | Of 67 cows with cystic ovarian disease (COD), 34 were injected intramuscularly with 20 mg of betamethasone of 10 mg of dexamethasone (CC) and 33 intravenously with a combination of 3,000 IU of human chorionic gonadotropin and 125 mg of progesterone (HCG -P). Pregnancy rates and intervals between treatment and conceptio... | 64,331 | [
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0.210224,
0.3651634,
0.1042894,
0.09560785,
0.1611269,
-0.093517... |
The definition of waking stages on the basis of continuous polygraphic recordings in normal subjects. | Polygraphic examinations were made during the day on 6 normal subjects. Simultaneous evaluation of EEG, EOG and EMG was carried out over 30 sec epochs. The data thus obtained were correlated with the various types of behaviour and activities during the day and then interpreted. Six conditions could be defined correspon... | 64,349 | [
0.1606752,
0.1812106,
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0.5291195,
0.2542891,
0.07137597,
0.3507807,
0.1731665,
0.1076828,
-0.1... |
Cellular subclasses in human leukemic hemopoiesis. | Cellular organization and communication in leukemic hemopoiesis may be compared with its counterpart in normal hemopoiesis. Results obtained using cell culture methods have provided some support for the view that leukemic hemopoiesis, like normla hemopoiesis, may involve 3 levels of differentiation: leukemic stem cells... | 64,380 | [
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0.02609208,
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[Results of palliative operations in infants with pseudotruncus arteriosus (author's transl)]. | A palliative procedure in patients with pulmonary atresia with VSD should improve arterial oxygen saturation, allow growth and development, and promotes a uniform dilatation of the pulmonary arteries. Thirty-three severely symptomatic patients, ranging from 5 days to 24 mths of age and from 2,4 to 11 kg of weight under... | 64,373 | [
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0.109577,
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... |
Filtrability of erythrocytes in "hypersplenic" rats. | The values of haemoglobin, reticulocytes and half-times of the filtrability of non-washed and washed erythrocytes were examined in male albino rats, Wistar strain, after i.p. injections of methylcellulose (MC) and compared with controls. In individual experiments the rats received 2 to 32 injections of MC. In injected ... | 64,395 | [
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0.0314264,
0.1761949,
-0.1200028,
0.09079087... |
[Fibrinolytic properties of a heparin-ocrase complex]. | The obtained heparin-ocrase complex includes properties of inhibiting coagulation and a high fibrinolytic activity in vitro and in vivo. The fibrinolytic activity of the heparin-ocrase complex is higher than the equivalent amount of ocrase. The fibrinolytic activity of the complex is not only evident on non-stabilized ... | 64,397 | [
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0.06936502,
0.2927568,
0.2992858,
0.4032888,
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-0.3358243,... |
[Studies on cryoprecipitates. 6. Osmolality and electrolyte conductivity]. | By measuring the osmolality of plasma and the cryoprecipitate gained by it as well as by measurements of conductivity the previously reported observations about the enrichment of electrolytes in cryoprecipitates could be confirmed. The findings show that these preparations represent hyperosmolic solutions. This fact sh... | 64,399 | [
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0.1995726,
0.278015,
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0.012353... |
[The transplantability of bone marrow and spleen cells after filtration through silon tissue]. | Investigations were carried out on the separation of haematopoietic stem cells from suspensions of the bone-marrow and spleen by means of filtration with silon tissue. The presence of stem cells in the filtrates was determined by the spleen colony test according to the method of Till and McCulloch in irradiated mice. T... | 64,407 | [
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0.1521053,
0.440408,
-0.1818255,
0.084769... |
[Blood morphology of the European eel (Anguilla anguilla). II. Studies on granulopoiesis]. | It was found that the granulocytes for Anguilla anguilla mainly form in the kidney. The stem cell of granulocytes is the large hemocytoblast. Sequences of development were established for the heterophil, cosinophil and basophil granulocytes. Myeloblasts, promyelocytes, metamyelocytes, mature red-shaped and segmented fo... | 64,409 | [
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0.02850613,
0.08466794,
0.2311796,
0.4654398,
0.2609232,
0.2560312,
-0.0806167... |
[The spontaneous lymphocyte transformation rate in newborn infants at risk]. | The lymphocyte transformation test was performed in 32 risk newborns and 32 comparative persons (17 adults, 15 children). In the void controls without antigen addition the newborns had a significantly higher spontaneous blastic reaction than the control group. The phenomenon may be explained by lymphatic stem cells in ... | 64,428 | [
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0.001155123,
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0.2428142,
0.5350958,
0.04812282,
-0.0256606... |
Hb Lepore and (haemo-) blastomata. | The still increasing amount of carriers and anemics by thalassemia (Th) and other Hb-pathies (approximately 4,000 among approximately 48,000 investigated people) have shown that Campania is the most affected world area by all Hb Lepre conditions. Among 161 people with heterozygous Hb Lepore we have noticed 10 cases ass... | 64,434 | [
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0.5347035,
0.07399801,
0.5858477,
0.3618258,
-0.02376474,... |
Survival and fertility of antibiotic-treated bovine spermatozoa. | Motility of spermatozoa stored at 5 C with up to 1000 units or mug of chloramphenicol, polymyxin, kanamycin, tylosin, ampicillin, lincomycin, spectinomycin, erythromycin, novabiocin, or terramycin per ml of extender was compared to that with penicillin plus dihydrostreptomycin. Novabiocin and terramycin were toxic, but... | 64,480 | [
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0.1038943,
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0.1243762,
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0.1765339,
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0.02061266,
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0.2627608,
0.23104,
... |
Harvester ant sensitivity: in vitro and in vivo studies using whole body extracts and venom. | Harvester ant stings by Pogonomyrmex maricopa (Pm) or Pogonomyrmex rugosus (Pr) resulted in serious reactions in 8 patients, 4 with generalized reactions and 1 with large local reactions. Exposure to one species in the genus Pogonomyrmex (P) appeared to cross-sensitize ant-sensitive patients to other species in the sam... | 64,481 | [
0.2496429,
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0.336134,
0.3990267,
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0.1623422,
0.169035,
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-0.... |
A general method for the rapid separation and specific detection of antigenic meterial by immunoelectrofiltration using multispecific antisera. | A general technique is described for the separation and detection of specific antigens from complex antigen mixtures, by their electrophoresis through antibody-containing gels. The method does not require purified reagent antigen or fuctionally monospecific antisera and should have a wide applicability in the detection... | 64,569 | [
-0.09744626,
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0.1814272,
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0.1855904,
0.3690726,
-0.1223491,
-0.07682806... |
The ethanol fractionation of mouse serum. | A method for the ethanol fractionation of normal mouse serum has been developed which is rapid and simple to perform. The method was shown to be effective in purification of IgG1, IgG2 and gammaM-gammaA globulins. Gel filtration and zone electrophoresis proved to be effective in separating the gammaM-gammaA globulin co... | 64,570 | [
-0.08941125,
0.07627439,
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0.3877813,
0.1514512,
-0.2866251,
-0.02216757,
-... |
Cross-antigenicity and immunogenicity between capsular polysaccharides of group C Neisseria meningitidis and of Escherichia coli K92. | Antibodies to capsular polysaccharides of group C Neisseria meningitidis are often found in sera of young adults despite infrequent nasopharyngeal carriage and low rate of attack of N. meningitidis in the United States. Thus, experiments were designed for detection of bacteria cross-reactive with N. meningitidis. Among... | 64,575 | [
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0.1343524,
0.3455683,
0.1520193,
-0.2636372,
... |
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