title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Mechanism of compact-colony formation by strains of Staphylococcus aureus in serum soft agar. | Compact-colony forming active substance (CCFAS), the material responsible for the compact colonies of Staphylococcus aureus observed in serum soft agar, was found to be an alkaline-stable, associated polysaccharide containing galactose, N-acetylglucosamine, ribitol, phosphorus and a small quantity of alanine. This subs... | 64,587 | [
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Erythrocyte-UFA (Eufa) mobility test for multiple sclerosis: implications for pathogenesis and handling of the disease. | Erythrocytes from patients with Multiple Sclerosis (MS) show a highly significant reduction in their absolute electrophoretic mobility in the presence of linoleic and arachidonic acids (LA; AA). Patients with other (destructive) neurological disease (OND) and normal subjects show an increased absolute mobility of their... | 64,595 | [
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Toxic polyneuropathies after sniffing a glue thinner. | In West Berlin in the autumn of 1975 through the following 5 months we observed 18 juvenile patients who had a toxic polyneuropathy and had sniffed a glue thinner. The neurological picture consisted of a symmetrical, progressive, ascending, mainly motor, polyneuropathy with pronounced muscle atrophy and characteristic ... | 64,597 | [
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Comparison of attitudes and cognitive achievement of nursing students in three instructional strategies. | This study is a comparison of the attitudes and the cognitive achievement of nursing students in three instructional strategies (the traditional lecture, black and white televised instruction, and independent color televised instruction via the Dial Access Information Retrieval System). Though only thirty-one percent (... | 64,603 | [
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Lymphocyte purine 5'-nucleotidase edficiency in primary hypogammaglobulinaemia. | The mean activity of purine 5'-nucleotidase (E.C.3.1.3.5) in lymphocytes was significantly lower in patients with non-familial adult onset "variable" primary hypogammaglobulinaemia than in non-hypogammaglobulinaemic control subjects. These findings suggest that 5'-nucleotidase activity is necessary for normal lymphocyt... | 64,699 | [
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Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia. Experience with 24 cases. | Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia was attempted in 24 pregnancies. Adequate amounts of fetal blood (for studying globin-chain synthesis) were obtained in 22 cases. 4 cases of homozygous beta-thalassaemia and 2 of sickle-cell anaemia were diagnosed. The difference between the homozygous and... | 64,802 | [
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Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia. | A soybean textured protein induced a 14% decrease of plasma-cholesterol levels after two weeks and 21% after three when substituted for animal proteins in a group of 20 patients with type-II hyperlipoproteinaemia. Comparison of soybean diet with a standard low-lipid diet in the same patients, according to a cross-over ... | 64,804 | [
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Concentrations of pregnancy-specific beta 1-glycoprotein in maternal blood in normal pregnancy and in intrauterine growth retardation. | A radioimmunoassay has been developed for pregnancy-specific beta 1-glycoprotein (S.P.1), a product of the human placenta. Circulating concentrations of S.P.1 were measured in 153 women in the third trimester of normal pregnancy and in 27 women who delivered children with birth-weight below the 10th centile of the norm... | 64,859 | [
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Ten model mutagens evaluated by the micronucleus test. | The following ten mutagenic compounds were subjected to the micronucleus bone marrow test (MNT) in the mouse: cyclophosphamide (CTX), thiotepa (TT), vincristin (VCR), colcemid (COLC), adriamycin (AM), bleomycin (BM), cytosin arabinoside (ARA C), 6-mercaptopurine (6-MP), methotrexate (MTX) and 5-fluorouracil (5-FU). Dos... | 64,925 | [
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Cytogenetic analysis of human chromosomes and its value for the estimation of genetic risk. | A short review of present-day contradictory opinions on the usefulness of human chromosomal analysis in the system of chemical mutagen testing is illustrated by examples of the results achieved by both conventional and banding techniques. The results include exposures of human chromosomes to ECHH and TEPA in vitro, and... | 64,926 | [
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Rates, sample sizes, and the neutrality hypothesis for electrophoresis in evolutionary studies. | It is shown that electrophoretic genetic distance estimates are highly correlated with albumin immunological distances between the same pairs of species. The bimodality of rates of electrophoretic differentiation at various loci is then documented and the electrophoretic clocks involved are calibrated. The differences ... | 64,931 | [
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An appraisal of symptom relief after coronary bypass grafting. | Subjective symptomatic improvement is experienced by 90% of patients after coronary bypass surgery. Objective exercise testing reduces this incidence to 70%. An analysis of the multifactorial genesis of pain relief based on data of non-randomized trials reveals that graft patency plays a dominant but not unique role in... | 64,978 | [
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Albumin phylogeny for clawed frogs (Xenopus). | Comparisons of albumin indicate that the frogs commonly used by North American molecular and developmental biologists under the name of Xenopus muelleri belong to another species, X. borealis. Phylogenetic analysis of the albumin data reveals two major groups of Xenopus species, one containing only X. tropicalis and th... | 65,013 | [
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Cell mediated lympholysis in man: an attempt to type with cytotoxic lymphocytes. | From approximately 3,000 CML combinations, originally established in order to evaluate the qualitative and quantitative influence of the serologically defined HLA-A, B, and C antigens on cellular, complement independent cytolysis, 12 combinations were selected yielding reproducible positive cytolysis on allogenic targe... | 65,022 | [
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[Effect of Filatov's tissue preparation and and a globulin preparation on weight gain in calves]. | A comparitive experiment was carried out with 81 calves, aged 4-15 days, to establish the effect of a tissue preparation of swine embryos after Filatov, colostral lactoplasmin, and bovine gammaglobulin as prophylactic and therapeutic means, on the sera proteins. It was found that these preparations show no influence on... | 65,047 | [
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Adenylate energy charge and the steroid 11 alfa-hydroxylase activity in Monosporium olivaceum during growth and starvation. | During growth of Monosporium olivaceum its energy charge, E.C., (i.e. the adenylates ratio ATP + 0.5 ADP/ATP + ADP + AMP) increased from an initial value of 0.59 up to 0.85 after 25 hr of growth and then decreased to 0.51. The increase of energy charge was followed by the decrease of the activity of the 11 alpha-hydrox... | 65,105 | [
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Physiology and characterization of a fungal milk-clotting enzyme from Aspergillus flavus. | Aspergillus flavus produced extracellularly an active rennin-like enzyme when grown aerobically in whey media. The enzyme was detected at early stages of growth reaching a maximum after three to four days at 25 degrees. The activity was destroyed by heating to temperatures higher than 50 degrees, whereas the presence o... | 65,107 | [
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[Hydroxy-ethyl-starch as plasma substitute in transurethral prostatectomy with the "cold-punch" method (author's transl)]. | Each of 24 patients undergoing transurethral prostatectomy under spinal anaesthesia received 1000 ml HES and, depending from the clinical situation, some patients received blood-transfusion. Afterwards two groups were formed: group A (11 patients), who received HES only, and group B (13 Patients) with additional blood-... | 65,133 | [
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Immunological comparison of enzymes of the beta-ketoadipate pathway. | beta-Carboxy-cis,cis-muconate lactonizing enzyme and gamma-carboxymuconolactone decarboxylase catalyze sequential reactions in the beta-ketoadipate pathway; the subunit sizes of the enzymes from Pseudomonas putida, biotype A, are 40 000 and 13 000, respectively. The cross reaction of antisera prepared against the enzym... | 65,161 | [
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Heterologous specificity of reticulin RS antibodies. | Reticulin antibodies were detected by the indirect immunofluorescence technique in 1450 sera from miscellaneous patients. R1 pattern on human and rat tissues was found only in 2 cases with adult coeliac disease. Reticulin Rs staining, involving intrasinusoidal cells of rat liver as well as interstitial and endothelial ... | 65,175 | [
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Antigens in human glioblastomas and meningiomas: Search for tumour and onco-foetal antigens. Estimation of S-100 and GFA protein. | Extracts of glioblastomas and meningiomas were analysed by quantitative immunoelectrophoresis for the presence of foetal brain antigens and tumour-associated antigens, and levels of 2 normal brain-specific proteins were also determined. The following antibodies were used: monospecific anti-S-100 (glia specific); monosp... | 65,176 | [
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Reaction of peptide 89-169 of bovine myelin basic protein with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-bromoindolenine. | The C-terminal half of the bovine myelin basic protein, peptide 89-169, was treated with BNPS-skatole [2-(2-nitrophenylsulfenyl)-3-methyl-3'-bromoindolenine], and the products were isolated by repeated gel filtration through Sephadex G-50. They consisted of uncleaved peptide 89-169 in which approximately 30% of the tyr... | 65,177 | [
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Cytochemical aspects of Mercenaria mercenaria hemocytes. | The hemocytes of the hard clam M. mercenaria were of three types: an agranulocyte, a small, and a large granulocyte. The agranulocyte, with only a thin periphery of cytoplasm surrounding the nucleus, had no visible cytoplasmic granules in living preparations but did exhibit a few centers of nonspecific esterase activit... | 65,187 | [
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The place of radiation therapy in the treatment of non-Hodgkin's lymphomas. | The use of Hodgkin's disease as a model for the evaluation and management of the non-Hodgkin's lymphomas may not be appropriate. This latter group of different syndromes and diseases differs significantly in their clinical presentation from each other as well as from Hodgkin's disease. Survival must be separated from r... | 65,208 | [
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Eight-drug combination chemotherapy (MOPP and ABDV) and local radiotherapy for advanced Hodgkin's Disease. | Thirty-seven patients with advanced Hodgkin's disease have been treated for greater than or equal to 3 months with a protocol consisting of alternate monthly courses of MOPP (mechlorethamine, Oncovin [vincristine], procarbazine, and prednisone) and ABDV (adriamycin, bleomycin, DTIC, and vinblastine) with local radiothe... | 65,221 | [
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Ultrastructural studies on the secretory cycle of the neurosecretory cells and the formation of Herring bodies in the paraventricular nucleus of the rat. | The ultrastructure of the neurosecretory cells in the paraventricular nucleus of the normal male rat was studied by electron microscopy during various functional states. Four morphologically distinct types of neurosecretory cells were observed. It appears that they do not represent different classes of cells but differ... | 65,228 | [
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Further evidence for the existence of intralobular nerves in the rat liver. | In a recent study (Skaaring and Bierring, 1976) we found cholinesterase-positive nerve-like structures in the lobules of rat liver, and scanning electron microscopy revealed cords having a distribution pattern similar to that of the cholinesterase-positive structures. To obtain further evidence for an intralobular nerv... | 65,229 | [
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Hippocampal RSA (theta), apnea, bradycardia and effects of atropine during underwater swimming in the rat. | Hippocampal RSA (theta), neocortical EEG, and heart rate were recorded during surface and underwater swimming in the rat. RSA was present with slightly reduced frequency during the apnea, bradycardia, and vibrissae arrest associated with under water swimming. Atropine sulfate (50 mg/kg) blocked bradycardia did not affe... | 65,274 | [
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Organization of sequences of avian globin mRNA. | Formamide polyacrylamide gel electrophoresis shows that chicken globin mRNA contains about 6.50 nucleotides, and since only 435 of these code for globin, a further 215 are not translated, and their function and position are not known. This work has produced the following conclusions. 1. 45-50 of these untranslated nucl... | 65,281 | [
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Argyrophilic cells in the larynx of the guinea-pig demonstrated by the method of Grimelius. | Argyrophilic cells with branching processes are shown in both the surface epithelium and in the glands in the larynx of adult guinea-pigs using the Grimelius silver technique after GPA fixation. When Bouin's fixative or neutral formalin were used as fixatives argrophilic cells could not be identified. | 65,349 | [
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Study of the pituitary-thyroid functions at high altitude in man. | The alterations in serum levels of T3, T4, TSH and TBG, TSH response to 100 mug iv TRH, and urinary excretion of T3 and T4 were studied in 8 healthy men at sea level (SL), on days 1, 2, 4, 8 and 16 after arrival by air at high altitude (3,700 m, HA), and during days 5 to 7 after their return to SL. No significant alter... | 65,358 | [
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The organization of the facial nucleus of the brush-tailed possum (Trichosurus vulpecula). | The facial nucleus of the brush-tailed possum has been studied using Nissl staining and the horseradish peroxidase (HRP) retrograde tracing technique. In Nissl stained sections the nucleus is seen to comprise five distinct subnuclei. Injections of HRP into individual facial muscle groups have shown that these subnuclei... | 65,363 | [
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Temperature and acid concentration in the search for optimum Feulgen hydrolysis conditions. | Exposure and removal of aldehyde groups during Feulgen acid hydrolysis were studied at a wide range of temperature and acid concentrations. Temperatures between 9 and 75degreesC were found to influence only the rate of the hydrolysis reaction over the entire range from high (6 M) to low (0.05 M) HCl concentrations. The... | 65,418 | [
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Antigen recognition: the specificity of an isolated T lymphocyte population. | Guinea pig lymph node lymphocytes were separated into T and B cell fractions on immunoabsorbent columns. Separated cells were functionally distinct: T cells proliferated in response to ConA, PHA, soluble and alloantigen, whereas anti-Ig reagents only stimulated B cells. The in vitro proliferative response of guinea pig... | 65,426 | [
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An antigenic subunit present in rotavirus infected faeces. | It has been found by immune electron microscopy that rotavirus-infected faeces, calf or human, contain an antigenic subunit associated with the inner of the two virus capsids. This internal component represents the group specific antigen for the rotavirus group and the subunit reacts with both homologous and heterologo... | 65,444 | [
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Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow up of 110 patients for 2-6 years. | 140 MS patients were treated with intensive I.V. cyclophosphamide immunotherapy and 110 were followed over 2-4 years. Annual relapse rate incidence was calculated over a period of 2 years before and after treatment and repeated neurological scores were made during this period. The conclusions are that 62% of the patien... | 65,452 | [
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Comparison of radiolabeled bleomycins and gallium citrate in tumor-bearing mice. | Radioiodinated bleomycin is a chemically stable radiopharmaceutical that can be prepared with high specific activity using 123I. Its pharmacokinetics were compared with those of 99mTc,- 111In-, and 57Co-bleomycin, and 67Ga citrate in mice bearing a transplanted KHJJ tumor. The in vivo kinetics and stability of 123I- an... | 65,460 | [
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Hyalin material bounding dystrophic calcification in the epithelial lining of odontogenic cysts. | Areas of dystrophic calcification present in the epithelial lining of two apical periodontal cysts have been shown to exhibit an outer layer of hyalin material. Similar calcific areas in the connective tissue walls do not show hyalin boundaries. Hyalin material has been found around muscle fibers present in the epithel... | 65,463 | [
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... |
Prevention of Fatal Postoperative pulmonary embolism by low doses of heparin. Reappraisal of results of international multicentre trial. | The results of a multicentre trial, designed to assess the efficacy of low-dose heparin in preventing fatal postoperative pulmonary embolism, were published in July 1975. In view of inconsistencies which have now become apparent in the data from one of the twenty-eight centres which took part in the trial, the results ... | 65,660 | [
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A fluorescence staining method for the examination of microorganisms on natural substrates. | A fluorescence staining technique is described which uses the magnesium salt of 1-anilino-8-naphthalene sulfonic acid as a protein stain. At a concentration of 2.5 or 3.0 mg ml-1 in distilled water or phosphate buffer the compound does not fluoresce under ultra-violet or far blue illumination until it is bound to a pro... | 65,720 | [
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Chemical modification of DNA polymerase phosphoprotein from avian myeloblastosis virus. | Fractionation of purified avian myeloblastosis virus DNA polymerase, after phosphorylation in vitro, revealed the presence of a small acidic proten, a phosphate acceptor polypeptide with high specific activity. Its presence in the phosphorylated form with the polymerase resulted in as much as a 10-fold increase in the ... | 65,734 | [
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[Evaluation of the relations between serum proteins electrophoresis and other laboratory tests in monoclonal gammopathies (author's transl)]. | We have considered interesting to determine monoclonal gammopathies incidence, in 2191 serum proteins electrophoresis performed in our laboratory from January to December 1974. We have found 15 cases of monoclonal gammopathies, some cases combined with Mieloma (3 cases), some other with other with non specific diseases... | 65,779 | [
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[Is there any bimodality of the age distribution of male mammary cancer (author's transl)?]. | The authors study the pattern of the curve concerning breast cancer incidence in males as a function of age. The demonstration is made that such a curve is bimodal and, more precisely, could be satisfactorily considered as being made up of the juxtaposition of two normal distribution curves. The interval thus individua... | 65,784 | [
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[A vertebral body implant for use in palliative surgery of spinal tumors (author's transl)]. | A newly developed vertebral body implant is discussed which is used to support and stabilize the spine after surgical removal of a vertebra in spinal tumors. | 65,845 | [
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[The influence of zink and lead on the formation of antibodies (author's transl)]. | Female NMRI-mice were injected intraperitoneally and subcutaneously with zinc chloride and lead chloride as well as with a mixture of both. The mice were also immunized with foreign-proteins. To demonstrate the interconections, the heavy metals and the proteins were injected separately, as was the heavy-metal-protein-s... | 65,877 | [
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Effect of encephalitogenic protein on migration in agarose of leukocytes from patients with multiple sclerosis. Variable effect of the antigen in a large dose range, with a literature review. | The literature on in vitro test of sensitivity to brain antigen in multiple sclerosis is summarized in the tables. A study is presented using leukocyte migration in agarose as test system and a wide range of concentration of bovine encephalitogenic protein as antigen. Definite reactivity was seen in 12 out of 28 patien... | 65,893 | [
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Molecular interactions in human atherosclerotic plaques. | Most plasma proteins appear to be present in intima at concentrations that are a linear function of molecular weight and concentration in the plasma. Thus low density lipoprotein (LDL) (molecular weight, 2 X 10(6)) has the greatest retention relative to its plasma concentration, whereas the relative retention of albumi... | 65,917 | [
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Further evidence for a central regulation of free fatty acid mobilization in the rat. | Previous studies have shown that anterior hypothalamic deafferentation in rats completely suppresses the increase in plasma free fatty acid (FFA), but not the hyperglycemia induced by administration of 2-deoxyglucose, suggesting a specific central regulation of FFA mobilization. The physiological importance of this fin... | 65,918 | [
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[Effect of prolonged glucidic starvation on the contents of starch and tannins of Blechnum brasiliense L. gametophytes]. | Some Blechnum brasiliense gametophytes have been maintained in darkness, in a purely mineral medium, for the purpose of investigating the effect of prolonged glucidic starving on the amount of tannins and starch that they contain. During the first two months the tannin contents undergoes a fast decrease. The starch var... | 65,957 | [
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[Decrease in maximum consumption of oxygen after blockage of beta-andrenergic receptors]. | VO2 max, maximum oxygen uptake, has been measured in 4 normal young men, before and after beta-adrenergic blockade (0.5 to 5 mg Pindolol by mouth). Pindolol induces bradycardia and reduces VO2 max. A statistically significant positive correlation appears between posology of Pindolol and bradycardia, this posology and r... | 66,035 | [
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[Free amino acids in sera of Cymothoidae (crustacean, isopods, parasites of fishes) and some teleosts]. | The free amino-acid composition of the sera of 4 species of Isopods Cymothoidae (Meinertia oestroides, Meinertia parallela, Emetha audouini, Anilocra physodes) are very similar, and present the same characteristics, both quantitatively and qualitatively, as those of free marine Isopods of the family Sphaeromatidae and ... | 66,040 | [
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[Free amino acids of hemolymph of marine isopods, Sphaeroma hookers Sphaeroma serratum (Flabellifera) and Idotea balthica (Valvifera)]. | The total concentration of the free amino acids in the hemolymph is higher (about twice the amount in three species of marine Isopods (Sphaeroma hookeri, S. serratum and Idotea balthica) than in Decapods. In the three species so far studied, the proportions of glycine and taurine are always rather high. In the Sphaerom... | 66,041 | [
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... |
Osmium dependent argentaffin reaction in the pancreatic islet. | By applying at the ultrastructural level the silver methenamine impregnation method to glutaraldehyde-osmium fixed pancreatic tissue of Snell-Bagg mice it was found that two islet cell types show deposition of reduced silver on their secretory granules: B cells and another cell type. Histochemical analyses indicate tha... | 66,046 | [
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... |
Pharmacodynamic actions of midodrine, a new alpha-adrenergic stimulating agent, and its main metabolite, ST 1059. | Pharmacodynamic actions of alpha-(2,5-dimethoxyphenyl)-beta-glycinamido-ethanol-hydrochloride (midodrine, Gutron) and alpha-(2,5-dimethoxy-phenyl)-beta-aminoethanol (ST 1059), the main metabolite of midodrine, were investigated in various experimental procedures. Midodrine raises arterial blood pressure both after pare... | 66,056 | [
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... |
[Properties and the protein composition of lymph and blood in burns]. | Experiments conducted on 25 dogs demonstrated that burn was accompanied by a regular redistribution of plasma proteins between the fluid media of the organism and an intensification of lymphogenic resorption. Properdin, albumin, and alpha2-globulin retardation in tissues in case of burn was demonstrated indirectly. The... | 66,073 | [
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0.2247802,
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0.01528668... |
Classification and audiovisuals. | The University of Connecticut Health Center Library's substantial investment in audiovisuals has prompted careful examination of its organization of the AV collection and its effectiveness in answering user needs. While an accession number system worked for a small collection, increased size quickly generated access pr... | 66,078 | [
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Mean velocity of optically detected intraaxonal particles measured by a cross-correlation method. | A method which uses by the cross correlation of optical signals is described for the determination of the mean velocity of somatopetally moving particles within nerve fibers. The method was validated by simulation experiments and by comparing the results with those obtained by averaging collections of velocities of ind... | 66,091 | [
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Far field somatosensory potentials in the rat. | Averaged somatosensory evoked potentials (SEPs) in the rat were recorded from skull electrodes. The cortical component of the SEP was preceded by at least three low amplitude potentials. Surface distribution of these potentials, correlation with depth recording from posterior columns, posterior column nuclei, inferior ... | 66,129 | [
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... |
New sphenoidal electrode assembly to permit long-term monitoring of the patient's ictal or interictal EEG. | A new sphenoidal wire electrode is described which greatly increases the clinical and diagnostic usefulness of sphenoidal electrode recordings. These very fine wire electrodes are easy to insert; they are comfortable and acceptable to the patient. In contrast to sphenoidal needle electrodes they expose the patient to n... | 66,141 | [
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Immunoglobulin-like messenger RNA in a mouse T cell lymphoma. | RNA-driven complementary DNA (cDNA) hybridization experiments have been carried out in order to detect complementary sequences in RNA prepared from a mouse T cell lymphoma line (EL4). In conditions where efficient hybridization of L-chain cDNA with homologous P3 myeloma mRNA was observed, poor hybridization was observe... | 66,149 | [
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The macrophage electrophoretic mobility test: Results on carcinoma of the colon and rectum. | The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reductio... | 66,210 | [
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0.1067921,
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RNA-dependent DNA polymerase of avian sarcoma virus B77. I. Isolation and partial characterization of the alpha, beta2, and alphabeta forms of the enzyme. | Three forms of the RNA-dependent DNA polymerase were isolated from highly purified avian sarcoma virus B77 grown in duck embryo fibroblasts, using sequential chromatography on DEAE-cellulose, phosphocellulose, and poly(U)-cellulose. One form, which sedimented with about 5.2 S, contained only one species of polypeptide,... | 66,234 | [
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Inhibition of the mixed lymphocyte culture response with anti-Lyb-4.1 serum 1,2,. | C57BL/Ks anti-L1210 serum, which recognized a non-H-2-linked B cell alloantigen, designated Lyb-4.1, specifically blocked the mixed lymphocyte culture (MLC) response to allogeneic cells that expressed the Lyb-4.1 determinant. Anti-Lyb-4,1 serum blocked the MLC response across H-2 and MLC disparities. To test that this ... | 66,278 | [
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Genetics of cell-mediated lympholysis in man. | Cell-mediated lympholysis (CML) was studied in a family containing two siblings in who genetic recombinaiton had occurred in the HLA comples. In one sibling, recombination occurred between the HLA-A locus and the HLA-B locus. In the second sibling recombination occurred between the HLA-B locus and the HLA-D locus. Stro... | 66,285 | [
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Antigen-binding lymphocytes in guinea pigs. I.B cell expansion to the monovalent antigen L-tyrosine-p-azophenyl trimethylammonium (tyr(TMA)) in the absence of antibody production. | The monofunctional antigen L-tyrosine-p-azophenyltrimethylammonium chloride, tyr(TMA), and the polyfunctional antigen, TMA-human gamma-globulin (TMA-HGG), were used to investigate the antigen structural requirements necessary for clonal proliferation of B cells. This clonal expansion was characterized with respect to r... | 66,287 | [
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Ionic selectivity, saturation and block in gramicidin A channels: I. Theory for the electrical properties of ion selective channels having two pairs of binding sites and multiple conductance states. | A model for the gramicidin A channel is proposed which extends existing models by adding a specific cationic binding site at each entrance to the channel. The binding of ions to these outer channel sites is assumed to shift the energy levels of the inner sites and barriers and thereby alter the channel conductance. The... | 66,317 | [
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Studies on an adrenal antigen common to man and different animals. | Precipitating adrenal antibodies, originally described by Andrada et al., are often associated with patients suffering from the moniliasis-polyendocrinopathy syndrome. The syndrome may include contemporarily several organ-specific autoimmune diseases such as hypoparathyroidism. Addison's disease, thyroiditis, perniciou... | 66,422 | [
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Treatment of severe intermittent claudication by controlled defibrination. | Fifteen patients with severe intermittent claudication were treated by therapeutic defibrination with subcutaneous injections of ancrod for 5 weeks. Mean plasma-fibrinogen was maintained below 50% of the initial value throughout the treatment period. This reduction in plasma-fibrinogen was accompanied by a parallel fal... | 66,429 | [
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Heart-rate variability in brain-damaged adults. | To test whether or not the characteristics of the adult heart-rate reflect the condition of the central nervous system (as they seem to do in the fetus), ten patients with neurological deficits of acute onset were studied. No patients had received drugs and none was hypoxic. The findings indicate that the normal cyclic... | 66,430 | [
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Treatment of symptomatic diverticular disease with a high-fibre diet. | The therapeutic value of increasing the daily dietary fibre intake was assessed over 3 months in a double-blind controlled trial of 18 patients. Significantly greater symptomatic relief was obtained by those on a high fibre regimen than by those in the control group, despite a marked initial placebo effect. The effecti... | 66,471 | [
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Cadmium and hypertension. | The cadmium concentration of renal tissue from 82 patients who had died at the age of 45-65 years has been determined by atomic absorption spectrophotometry; 43 were normotensive and 39 hypertensive. Renal cadmium concentration was higher in normotensives than in hypertensives. When smoking habits were taken into accou... | 66,476 | [
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[Distribution of certain enzymes in totally stained Cestode preparations]. | The distribution of succinic dehydrogenase, HApi-diaphorase, glucose-6-phosphatdehydrogenase, alkaline and acid phosphatases and glucose-6-phosphatase was studied by means of the incubation of whole cestodes. Succinic dehydrogenase, NAD-diaphorase and glucose-6-phosphatdehydrogenase are connected in general with the fi... | 66,656 | [
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Expression of antigenic crossreactivity to RD114 p 30 protein in a human fibrosarcoma cell line. | An antigen crossreacting with the 30,000-molecular-weight protein (p30) of the feline endogenous oncornavirus (RD114) was detected in a well-characterized human fibrosarcoma cell line, HT1080, by indirect immunofluorescence. Three antisera against RD114 p30 gave similar positive results, while two antisera prepared aga... | 66,679 | [
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Histamine-releasing effect of a corticotrophin derivative. I. Histamine-releasing effect of a nonadecapeptide in comparison with that of other histamine liberators. | The histamine-liberating properties of a synthetic polypeptide (an a synthetic polypeptide (an alkylprolyl derivative of beta1-19-corticotrophin) were investigated under a variety of experimental conditions. It was found to be more potent in this respect than Compound 48/80, Melittin and Triton X-100. The degree of cel... | 66,701 | [
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The absence of a human thymus lymphocyte antigen (HTLA) on basophils and mast cells. | Basophilic granulocytes and mast cells of different species have been reported to originate from thymocytes and other lymphocytes. These observations were recently confirmed when evidence was given that thymic antigen is present on rabbit basophilic granulocytes. In the study reported here, human leukocytes were tested... | 66,740 | [
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Some characteristics of Mozambican Shangaans with primary hepatocellular cancer. | Certain characteristics of 328 Mozambican male Shangaans with primary hepatocellular cancer (PHC) have been compared with those of 163 Shangaan men with hepatomegaly from causes other than PHC and with those of 122 Black Southern African men with the same tumour but who belonged to tribes other than the Shangaan. Shang... | 66,757 | [
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Further evidence for the involvement of base and base sequence in the antigenic determination of thermally denatured DNA. | The antigenic determinant of thermally denatured salmon sperm (ss) DNA was extensively investigated with a radioimmunoassay technique using the ssDNA immune system. It was demonstrated that mixed sequences of purines and pyrimidines play a key role in the antigenic determination of DNA. On the other hand, the importanc... | 66,773 | [
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Duplication of the haemoglobin alpha-gene. | Gene duplication is one of the basic processes underlying evolutionary changes. The gamma-chains of human foetal haemoglobin is coded by multiple structural genes. The delta-chains of Hb A2 can be regarded as a duplication of the beta-locus. We have presented the first evidence for the presence of two major alpha-chain... | 66,838 | [
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Atypical stromal hyperplasia of the prostate gland. | Hyperplastic lesions of the prostatic stroma with atypical changes are presented and discussed. One lesion was a leiomyoma with atypical organization and a limited area of nuclear pleomorphism without mitotic figures. One was a lesion which in many portions was histologically indistinguishable from leiomyosarcoma. It, ... | 66,868 | [
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[Triggering of human peripheral blood B cells by supernatants of activated T cells: the role of Ia-like determinants]. | Human peripheral blood B lymphocytes, isolated by Sephadex G-200 anti-Fab column chromatography, were non specifically induced by either pokeweed mitogen (PWM) or soluble products of antigen stimulated T cells, to differenciate into plaque directed against human Ia-like antigens (anti-p 23-30) inhibited the differencia... | 66,895 | [
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Experimentally induced bleomycin sulfate pulmonary toxicity: histopathologic and ultrastructural study in the pheasant. | Morphological alterations in the lungs of pheasants after prolonged high-dosage administration of bleomycin sulfate were studied by light and electron microscopy. Nontreated birds acted as controls, and their lungs showed no abnormalities. Lungs of bleomycin-treated pheasants revealed collapse alternating with overexpa... | 66,910 | [
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Alpha-foetoprotein and carcinoembryonic antigen in germ cell neoplasms. | Serum alpha-foetoprotein (AFP) and serum carcinoembryonic antigen (CEA) levels were measured, serially whenever possible, in 70 patients attending the Institute of Radiotherapy, Rotterdam, on account of testicular (65) or ovarian (4) germ cell tumours or, in one case, an endodermal sinus (yolk sac) tumour in the medias... | 66,925 | [
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0... |
The secondary structure of myelin basic protein extracted by deoxycholate. | Because of the implication of myelin basic protein in some neurological diseases its in vivo structure is of particular interest. The protein is usually isolated using organic solvents and acid solutions and has previously been shown to contain little alpha-helical or beta-structure; but it is not known how the extract... | 66,935 | [
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0.06771161,
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0.009705159,
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0.3386545,
-0.0... |
[In vitro and inhibition of anaphylactic reactions 1-methyl-3-isobutylxanthine]. | 1-methyl-3-isobutylxanthine (MIBX), a potent antiphosphodiesterase drug, inhibited the anaphylactic reactions both in vitro and in vivo: anaphylactic histamine release from the isolated mast cells of rats, anaphylactic contracture of the isolated trachea of guinea pigs, passive cutaneous anaphylaxis (PCA) in mice and a... | 66,950 | [
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0.2231646,
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0.3950713,
0.3756118,
0.2495802,
0.0123451,
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The effect of cations on C-band formation in human chromosomes. | A number of salt solutions were tested for their ability to replace 2 X SSC in the production of C-bands with the so-called CT technique. Those containing monovalent cations, except for the ones with Ag+ ions, were capable of inducing C-bands in Ba(OH)2-pretreated human chromosomes. Cesium cations were the most effecti... | 67,010 | [
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0.1158499,
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0.3464091,
0.545253,
0.1765234,
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-... |
Pathophysiology of generalized penicillin epilepsy in the cat: the role of cortical and subcortical structures. I. Systemic application of penicillin. | The mechanism of precipitation of generalized epileptiform discharges in feline generalized penicillin epilepsy, a model of human generalized corticoreticular ('centrencephalic') epilepsy, was studied in acute and chronic experiments in cats with implanted skull and intracerebral electrodes. Single shock and low freque... | 67,024 | [
0.1325733,
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0.1255463,
0.07907543,
-0.06613692,
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0.09497055,
0.2115132,
-0.2441565,
0.002434915,
0.04643598,
0.2677601,
0.1762178,
-0.4... |
General-purpose timer from transistor logic to auxiliary equipment. | This paper describes a low-cost circuit for the control and timing of auxiliary experimental equipment by a variety of signals from 5 V, integrated-circuit logic. The circuit is designed for variable timing and switching up to 240 AC V at 3 A, with two independent timing parameters, delay and duration, in response to p... | 67,033 | [
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0.08727569,
0.05713207,
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0.06841363,
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0.194399,
0.1282828,
0.1504438,
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0.08434918,
0.1378167,
0.002868177,
0.02718627... |
Comparison of diagnostic accuracy of different peripheric parameters of thyroid function. | Diagnostic value of a scope of peripheric parameters of thyroid function was assessed in an unselected group of untreated patients with suspected thyroid disorder, further in untraeted selected patients (without cardiac involvement) and in treated patients. Comparison of relative values of individual tests was perform... | 67,035 | [
-0.0008498667,
-0.2232122,
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0.5825855,
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0.3286496,
0.1979632,
0.2109648,
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0.1060054,
-0.07801945,
0.2282673,
0.4568311,
0.1699812,
-0.1906102,
... |
Multiple sclerosis: a clinico-biological study of 100 cases in Spain. | A study was carried out on 100 cases with the clinical diagnosis of multiple sclerosis. Several clinical and analytical factors were considered and correlated. Special attention was paid to data obtained from cerebrospinal fluid (CSF) electrophoresis. The degree of severity of the disease does not affect the selective ... | 67,039 | [
-0.005480799,
-0.09207841,
0.09999508,
0.01592106,
0.1122985,
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0.2890659,
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0.1475244,
0.1041552,
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0.07035372,
-0.04720871,
0.2181882,
0.1472988,
-0.03195338,
0.3865972,
0.01890... |
Fluorescent C bands of human chromosomes with 33 258 Hoechst stain. | Air-dried preparations of human metaphase chromosomes normally exhibit a Q band fluorescence pattern with 33 258 Hoechst stain while the C band regions of 1,9,16, and most acrocentric short arms appear dull. If these stained and mounted slides are stored at room temperature in the dark for several days, a spontaneous c... | 67,076 | [
-0.1372877,
0.200765,
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0.2167004,
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0.06030709,
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0.2492037,
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0.1435367,
0.3971443,
0.269956,
-0.1147386,
-0.01... |
Immunological properties of ampicillin polymers. | The immunologic effects of ampicillin polymers were studied in mice and rabbits. Polymerized ampicillin--in contrast to monomers--had a suppressive effect on the antibody response to penicilloylated proteins. Unfractionated ampicillin polymer, and high molecular weight fractions were found to have an immunogenic effect... | 67,086 | [
0.1711628,
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0.2218537,
0.08134307,
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0.09896068,
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0.04913332,
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0.3201177,
0.09014802,
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0.2301461,
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0.3023435,
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0.314016,
0.37625,
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0.06445805,
-0... |
Failure of increased intracranial pressure to affect rapid axonal transport at the optic nerve head. | In owl monkeys, elevation of intracranial pressure to 500 mm. saline for 4 to 7 hours failed to cause an accumulation at the optic nerve head of protein carried by rapid axonal transport. This suggests that the block of rapid transport observed by others during papilledema may be the result of axon swelling, not its ca... | 67,095 | [
0.1121655,
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0.08037887,
0.161631,
0.1175156,
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0.03476561,
0.1059398,
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-0.2836736,
0.005531482,
-0.168785,
-0.1708104,
0.1724842,
-0.003210112,
0.07177003... |
Bladder wall tension in benign prostatic hypertrophy. | Two hundred forty-three synchronous urinary flow and intravesical pressure recordings were carried out on 51 men all of whom were over 50 years of age. They consisted of 12 normal subjects and 39 patients with benign prostatic hypertrophy in various stages of bladder outlet obstruction. Bladder wall tension was determi... | 67,098 | [
-0.1204998,
0.03210144,
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0.05207784,
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0.1532008,
0.03000385,
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0.06051622,
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0.2064847,
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-0.402542,
0.4921587,
0.04850817,
-0.042317... |
Specificity of the Tumor-specific transplantation antigen induced by JC virus, a human polyomavirus. | The specificity of the tumor-specific transplantation antigen (TSTA) induced by JC virus was investigated by cross protection tests in weanling hamsters. Hamsters immunized with JC virus, BK virus, or SV40 were challenged 5 weeks later with known numbers of JC virus- or SV40-induced hamster tumor cells. Both the JC vir... | 67,106 | [
0.1131924,
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-0.2777482,
0.1140897,
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0.2959768,
0.2103149,
0.1902923,
0.2802989,
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0.01776175,
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-0.3050072,
0.01840275,
0.1829075,
0.04263401,
0.05394451,
0.08641578,
-0.2028326,
... |
Microfluorometric analysis of cellular DNA following incorporation of bromodeoxyuridine. | Bromodeoxyuridine (BrdU) incorporation into cellular DNA has a differential effect on the cell-associated fluorescence of several DNA-specific dyes. After cells were treated with BrdU, flow microfluorometry was used to study the relative increase or decrease influorescence of stained cells. Bromodeoxyuridine incorporat... | 67,119 | [
-0.1369506,
-0.1042488,
-0.2149104,
0.2724287,
0.3306296,
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0.1203734,
-0.06131474,
0.3194716,
0.1232066,
0.01295223,
0.1064429,
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0.2674655,
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0.290154,
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0.4652745,
0.7827652,
-0.09107629,
0.06289607,
-0.2... |
A comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain. | The relative analgesic potency of oxymorphone by rectal suppository and intramuscular injection was evaluated in a double-blind, twin-crossover comparison of graded single doses in 136 patients with postoperative pain. The time-effect curves of the two routes of administration differed substantially; rectal resulted in... | 67,128 | [
0.04575193,
-0.1014379,
-0.2178436,
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0.1127453,
0.02121779,
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0.0667671,
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0.002634826,
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0.2177496,
-0.003375735,
0.3452469,
0.2519356,
-0.0117... |
Experimental infection with Ancylostoma caninum larvae in mice. IV. Serum protein pattern during primary infection. | Serum protein of Swiss albino mice infected with Ancylostoma caninum larvae, were analysed electrophoretically. Twenty mice were infected with a dose of 1000 larvae and the alterations in serum protein during an infection period of 30 days were recorded and compared with uninfected controls. The result showed a signifi... | 67,139 | [
-0.08530621,
-0.05894589,
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0.1947278,
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0.03425523,
0.3006755,
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0.09541423,
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-0.3398819,
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-0.04692513,
0.0668788,
-0.03270369,
0.234703,
-0.0976... |
Murine plasma cells secreting more than one class of immunoglobulin heavy chain. II. SAMM 368--a plasmacytoma secreting IgG2b-kappa and IgA-kappa immunoglobulins which do not share idiotypic determinants. | SAMM 368 is a BALB/c plasmacytoma which secretes IgG2b-kappa and IgA-kappa paraproteins. Immunofluorescence studies of ascites cells from the tumor with purified, heavy chain class-specific antiglobulins demonstrate that single cells contain both IgG2 and IgA heavy chains. Idiotypic antisera prepared in mice and rabbit... | 67,144 | [
-0.01589386,
-0.2488643,
-0.3178326,
-0.587781,
0.1773185,
0.08134417,
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0.1711539,
0.2499943,
0.3028636,
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0.001732667,
0.2804851,
0.02180355,
-0.2655861,
... |
Studies on H-2 specificities on mouse tumour cells by a new microradioassay. | Seven mouse tumour cell lines of different aetiology and origin were tested for the expression of surface alloantigens using twenty-four well defined H-2 alloantisera and anti-Thy 1.2. We used a new radioassay that involves antibody-complement treatment of the tumour target cells followed by postlabeling the surviving ... | 67,153 | [
-0.05791733,
-0.3120157,
-0.4249478,
-0.1476114,
-0.02549529,
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0.2477768,
0.2038293,
0.2360325,
0.04402355,
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0.2335941,
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0.2058649,
0.3819517,
0.3306782,
-0.2703129,... |
Effect of combinations of penicillin and aminoglycosides on Streptococcus faecalis: a comparative study of seven aminoglycoside antibiotics. | The 50% inhibitory concentrations (IC50) of benzylpenicillin, streptomycin, sisomicin, gentamicin, tobramycin, kanamycin, amikacin, and butirosin were determined for 58 clinical isolates of Streptococcus faecalis, 28 of which were recovered from cultures of blood samples from patients with endocarditis. The IC50 of str... | 67,159 | [
0.09754729,
0.1839723,
-0.4392507,
0.04667508,
0.1402447,
0.04283586,
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0.3504658,
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0.01894511,
0.09588633,
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0.05243064,
-0.1742348,
0.5934464,
0.1399088,
0.004641317,
0.2633283,
... |
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