title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Nucleolus organizers in Mus musculus subspecies and in the RAG mouse cell line. | Silver staining has been used to detect active nucleolus organizer regions (NOR's). By this criterion six mouse chromosomes, numbers 12, 15, 16, 17, 18 and 19, can have an NOR. The number and distribution of chromosomes with NOR's vary among inbred strains of Mus musculus musculus (C57BL/6J, BALB/cJ, C3H/HeJ and C3H/St... | 69,563 | [
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Juvenile pernicious anemia associated with intestinal nodular lymphoid hyperplasia and immune deficiency state. Report of a case. | A 17-year-old girl with humoral immune deficiency state was observed, in whom pernicious anemia developed one year before her death. The patient died after a very severe diarrheal attack and respiratory tract infection. The necropsy revealed intestinal nodular lymphoid hyperplasia. The immunological evaluation showed d... | 69,572 | [
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[Clinical trial with long-term therapy of generalized plasmacytoma]. | The authors report on findings in long-term therapy made by means of a combination of cyclophosphamide as attack dosis (partially also with polychemotherapy--COP, COPP-scheme) and double plasmapheresis. Since 1967 33 patients have been treated in this way. A group (6 patients) only received cyclophosphamide in a attack... | 69,574 | [
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Some aspects of haematology of an Indian grass snake Natrix stolata in relation to sex and size. | Studies have been made on the erythrocyte counts per mm3 of blood, total differential leucocyte counts per mm3 of blood, concentration of haemoglobin per 100 ml of blood, haematocrit values and nucleocytoplasmic ratio in a common Indian grass snake, Natrix stolata, in relation to body weight of both the sexes in the sa... | 69,577 | [
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[Alcian blue induced mixed cell agglutination--short communication]. | Because of its specific affinity to negatively charged sites of the cell surface, alcian blue is suitable to effect mixed cell agglutination between human erythrocytes and peritoneal macrophages of guinea pigs. This effect could be inhibited by adding heparin molecules which were negatively charged as well. | 69,579 | [
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Further studies on passive peritoneal anaphylaxis in the rat. | Four compounds with H1 anti-histamine activity and four adrenoceptor stimulants, each given to rats prior to passive peritoneal anaphylaxis (PPA), inhibited extravasation of serum proteins into the peritoneal fluid at doses which had no effect on histamine release. In contrast, aminophylline and some non-steroidal anti... | 69,615 | [
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Effects of primary antiserum dilution on staining of "antigenrich" tissues with the peroxidase antiperoxidase technique. | The effect of primary antiserum dilution on staining results with the peroxidase antiperoxidase method were investigated using frozen sections of perfused rat cerebellum and optic nerve. Results comparable to formalin fixed and paraffin embedded tissue were attainable only when low antiserum concentrations were used. O... | 69,655 | [
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Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines. | Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that... | 69,670 | [
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Evaluation of an electronic device for gingival fluid quantitation. | A number of factors which might affect the readings of the HAR-600 GCFM were studied: 1. The readings were higher when the filter paper strips were placed between the fron halves of the upper and lower counterparts than when they were placed between the rear halves. No differences in readings were observed when the str... | 69,703 | [
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Distribution and expression in mammals of genes ralated to an endogenous type C RNA virus of Odocoileus hemionus. | An endogenous type C virus recently isolated from the Columbian black-tailed deer (Odocoileus hemionus) was used as a molecular probe to study the distribution of virus-related nucleotide sequences in cellular DNAs of mammalian species. By DNA-DNA hybridization, the most extensive homology was demonstrated between the ... | 69,718 | [
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Identification of the Gross cell surface antigen associated with murine leukemia virus-infected cells. | The Gross cell surface antigen (GCSA) is produced by cells that are either exogenously infected with murine leukemia virus (MuLV) or are expressing endogenous MuLV genomes. In immune precipitation assays, GCSA was resolved into two serologically distinct 85,000- and 95,000-dalton viral proteins. These antigenic compone... | 69,726 | [
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Inhibition of cholecystokinin-pancreozymin release by somatostatin. | To determine the effect of somatostatin on cholecystokinin-pancreozymin (C.C.K.) release, serum-C.C.K. concentrations were measured in normal volunteers after intraduodenal olive oil, with and without a simultaneous intravenous infusion of somatostatin. After instillation of the olive oil there was a rapid rise in seru... | 69,783 | [
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Disease-surveillance and decision-making after the 1976 Guatemala earthquake. | In the first 3 weeks after the 1976 earthquake in Guatemala a system for collecting, analysing, and disseminating information of medical importance was instituted in the disaster area. Data on cases of selected diseases, number of available hospital beds, and medical supplies were collected, and reported epidemics were... | 69,793 | [
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Suicide prevention by the Samaritans. A controlled study of effectiveness. | To test the hypothesis that Samaritan services prevent suicide, the trends in suicide-rates of county boroughs with Samaritan services have been compared with trends in matched control boroughs without Samarian services. The suicide-rate for both groups of boroughs has decreased progressively and to the same extent. Th... | 69,841 | [
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Detection of acute myocardial infarction by radioimmunoassay for creatine kinase MB. | A radioimmunoassay for the MB isoenzyme of creatine kinase (myocardial isoenzyme) has been developed based on an antibody to the B subunit. The antibody cross-reacts with MB but exhibits no cross-reactivity with MM C.K. even when present in 20 000 molar excess over MB C.K. unlabelled MB but not MM (up to 85 000 mI.U./m... | 69,933 | [
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Familial studies of type-I and type-II idiopathic diabetes mellitus. | A study of 296 diabetics demonstrated an association between the type of diabetes in the propositi and their first-degree relatives (aged 40 to 89 yr), the type of diabetes being defined as insulin-dependent (type I) or insulin-independent (type II). This association was significant at the 1% level and was still mainta... | 69,935 | [
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Munchausen syndrome by proxy. The hinterland of child abuse. | Some patients consistently produce false stories and fabricate evidence, so causing themselves needless hospital investigations and operations. Here are described parents who, by falsification, caused their children innumerable harmful hospital procedures--a sort of Munchausen syndrome by proxy. | 69,945 | [
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alpha-Fetoprotein is not a component of the estradiol receptor of the rat uterus. | In high-salt medium, cytosol from immature rat uteri displays two main high-affinity estradiol-binding peaks after ultracentrifugation in a sucrose gradient. The two components are the estradiol receptor which has a sedimentation coefficient of 5.5 S, and the alpha-fetoprotein which sediments at 4.5 S. The dissociation... | 70,036 | [
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Terminally repeated sequences in the avian sarcoma virus RNA genome. | The initiation of DNA synthesis in vitro by RNA-directed DNA polymerase (deoxynucleosidetriphosphate: DNA deoxynucleotidyltransferase, EC 2.7.7.7) of avian oncornaviruses requires a tRNAtrp primer molecule located close to the 5' end of the viral RNA genome. DNA transcripts, 100 nucleotides in length, initiated on the ... | 70,037 | [
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Structure of the gramicidin A channel: discrimination between the piL,D and the beta helix by electrical measurements with lipid bilayer membranes. | Measurements with different chemically modified gramicidins in lipid bilayer membranes were used to discriminate between the dimeric pi(L,D) helix proposed by Urry and the dimeric parallel or antiparallel helices proposed by Veatch and Blout. Evidence for the pi(L,D) helix was obtained on the basis of the different act... | 70,038 | [
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The study of human Aa-like specificities using antibody eluates from human lymphoblastoid cell lines. | Five sera from multiparous women were absorbed and eluted from the Daudi cell line devoid of HLA antigens. These eluates recognized a specificity, Ly-Lil, of the Ly-Li system. Further absorption of one eluate in Bjab or Raji cell line subdivided this specificity. Family studies showed that the five eluates from the Dau... | 70,057 | [
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Relation between HLA-DW and the b-lymphocyte specificities. | Homozygous DW typing cells were tested for six B-lymphocyte specificities. All four of the second locus specificities of B lymphocytes were strongly associated with the DW specificities. DW1 typing cells were B group 6, DW2 were B4, DW3 were B5, and LD107 were B3. The first B-cell locus antigens 1 and 2 tended to be un... | 70,058 | [
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Cellular distrubtion, purification, and molecular nature of human Ia antigens. | Human Ia antigens were extensively purified (1390-fold increase in specific activity) in 32% yield from BRI 8 cells, a lymphoblastoid B-cell line. Purification was monitored by using allogeneic antisera arising by foetal-maternal stimulation. The product, a glycoprotein fraction, contained the Ia antigens, the HLA-A an... | 70,062 | [
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Detection of HLA-D clusters using primed LD typing. | Using a set of 17 primed LD typing (PLT) cells tested on a panel of 35 unrelated cells, we showed that certain groups of PLT cells tended to detect similar unrelated cells. The PLT cells were grouped into seven clusters and these tended to correlate with the seven HLA-D specificities represented on the panel, as determ... | 70,067 | [
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Detection by three cellular immunological techniques of the antigenic determinants of the Ly-Li system, expressed on human B lymphocytes. | A clear correlation was observed between the presence of an Ia-like antigenic B-cell system Ly-Li, detected serologically, and three cellular immunological techniques: [1] mixed lymphocyte reaction (MLR) inhibition by an anti-Li antiserum; [2] level of restimulation of anti-Ly-Li in-vitro-primed lymphocytes; and [3] de... | 70,070 | [
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Cytochrome staining of leukocytes in urine sediment. Assessment of inflammatory state. | Urinary sediments with significant pyuria were supravitally stained to assess the inflammatory state. Clinic patients showed a significant correlation between acute urinary infection, inflammation, and the predominance of live polymorphonuclear leukocytes. Post-transurethral prostatic resection patients demonstrated to... | 70,100 | [
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Klinefelter syndrome in the aged. | Three cases of Klinefelter syndrome diagnosed late in life are reported with the clinical and post-mortem findings. The diagnosis was suspected owing to the absence of testes and the presence of associated varied clinical features. The urinary follicle-stimulating hormone levels were not elevated and were very low in t... | 70,164 | [
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Percutaneous transthoracic needle aspiration of the lung. Diagnosing Pneumocystis carinii pneumonitis. | Percutaneous transthoracic needle aspiration was performed on 228 occasions to obtain lung specimens from 202 patients with suspected Pneumocystis carinii pneumonitis. In 121 patients the diagnosis was established by identifying P carinii organisms in lung aspirates. Six patients whose aspirates did not contain P carin... | 70,167 | [
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0.4542974,
0.02076669,
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0.3031113,
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-0.102217,
0.4366243,
0.1599039,
0.3144192,
0.3... |
Cytochemical "normal" and "abnormal" eosinophils in acute leukemias. | Eosinophilic leukocytes may accompany a great variety of disorders and different types of acute leukemias. The most striking morphologic feature of eosinophils is their specific granules, but morphology alone often is insufficient to differentiate normal from abnormal eosinophils. Cytochemically, the eosinophils were c... | 70,168 | [
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Analysis of serum proteins and cerebrospinal fluid in clinically normal horses, using agarose electrophoresis. | Using agarose as a supporting matrix, electrophoresis was conducted on 50 serum samples and 20 cerebrospinal fluid samples from clinically normal horses (n = 50) of various ages and breeds. The technique was shown to be reliable. A positive correlation between age and gamma-globulin concentration was found in young hor... | 70,183 | [
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Maternal serum alpha-fetoprotein and spontaneous abortion. | The relationship between spontaneous abortion and maternal serum alpha-fetoprotein (AFP) levels was investigated between 9 and 25 weeks of pregnancy. Seven out of 126 (5-6 per cent) women who had spontaneous abortions had raised maternal serum AFP levels at their antenatal booking visit compared to 4 out of 247 (1-6 pe... | 70,212 | [
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Proton nuclear magnetic resonances study of bleomycin in aqueous solution. Assignment of resonances. | The 1H NMR spectrum of the glycopeptide antineoplastic antibiotic bleomycin has been examined in D2O solution (Fourier transform nuclear magnetic resonance, 270 MHZ) and in H2O solution (correlation nuclear magnetic resonance, 250 MHZ). Resonances have been assigned to specific hydrogens of the two most abundant congen... | 70,218 | [
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Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies. | The interaction of bleomycin A2 with DNA has been examined by fluorescence spectroscopy and proton magnetic resonance techniques. Fluorescence bands observed at 353 and 405 nm in the spectrum of bleomycin were assigned to the bithiazole and 4-aminopyrimidine rings, respectively. Quenching of bithiazole fluorescence by ... | 70,220 | [
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... |
[Substrate specificity and some properties of free and immobilized animal alpha-L-fucosidase]. | The effect of a partially purified preparation of pig kidney alpha-L-fucosidase on some glycoproteins--human and rabbit gamma-globulin, glycoprotein from sheep submaxillary gland and ceruloplasmin--was studied. It was shown that the action of the enzyme of the glycoproteins was not accompanied by a release of fucose. A... | 70,233 | [
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0.... |
Has small-scale audio-visual dental health education a viable future? | The achievement of an adequate oral hygiene status in large groups of people remains an unfulfilled objective of the dental profession. In this study an attempt was made to motivate 180 pregnant women by showing them a tape-slide program. The subjects were randomly allocated into four statistically equal experimental g... | 70,320 | [
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0.3... |
An electrophoretic investigation of the binding of 3-14C coumarin to rat serum proteins. | The binding of coumarin to serum proteins of the rat has been demonstrated. Of the total bound coumarin (37% of injected dose), 36% was bound to slow and fast oc1 globulins, 11% to the post albumins, 10% to globulin and 9% to albumin. | 70,376 | [
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0.09... |
Gastrin cell immunofluorescence in conventionally fixed and stained tissue sections. | We describe a method for visualizing gastrin cells by immunofluorescence that can be applied to tissues conventionally fixed and previously stained with hematoxylin and eosin. It results in a clear demonstration of surrounding structures. This technique permits the use of a broad of histological specimens for gastrin i... | 70,389 | [
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The RNA-dependent DNA polymerase of avian sarcoma virus B77. Binding of viral and nonviral ribonucleic acids to the alpha, beta2, and alphabeta forms of the enzyme. | The extent of binding of various RNA species to the three forms of avian sarcoma virus B77 RNA-dependent DNA polymerase was determined using a sensitive nitrocellulose filter binding technique which was capable of detecting binding reactions with association constants as low as 3 X 10(6) liters X mole-1. All three enzy... | 70,428 | [
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Flow system fluorescence polarization measurements on fluorescein diacetate-stained EL4 cells. | We have adapted a multiparameter cell sorter to measure the distribution of fluorescence polarization in cell populations. Measurements carried out on EL4 cells show that the percent polarization of fluorescein fluorescence decreases with increasing fluorescence intensity. This inverse relationship between polarization... | 70,456 | [
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Recognition of cells in mitosis by flow cytofluormetry. | Cells in mitosis may be distinguished from interphase cells based on difference in chromatin structure as revealed by two different methods of staining with acridine orange. In the first method, cells are heated and then stained at neutral pH; the difference in stainability between mitotic and interphase cells reflects... | 70,457 | [
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0.0284636... |
The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes. | Mice infected with herpes simplex virus develop little or no cytotoxic T lymphocyte (CTL) response. However, in lymph nodes (LN's) draining a local site infected with HSV, antigen-specific CTL precursors are sensitized, which upon transfer to in vitro culture conditions develop within 72 hr into effective CTL. The in v... | 70,478 | [
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Immunoregulation of experimental allergic encephalomyelitis: conditions for induction of suppressor cells and analysis of mechanism. | We determined requirements for the induction of immunoregulatory suppressor cells in experimental allergic encephalomyelitis (EAE) in Lewis rats. Pretreatment of rats with myelin basic protein (BP) in incomplete Freund's adjuvant (IFA) stimulates the proliferation of suppressor cells that localize in lymph nodes and sp... | 70,489 | [
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Cytotoxic T-cell response to Ectromelia virus-infected cells. Different H-2 requirements for triggering precursor T-cell induction or lysis by effector T cells defined by the BALB/c-H-2db mutation. | The T(c)-cell response to ectromelia virus infection was studied in BALB/c-H-2(db) mice which carry a loss mutation in the H-2D region that results in the absence from cell surfaces of a molecule (D') bearing certain public H-2 specificities. When infected, these mice showed a poor response of T(c) cells that recognize... | 70,498 | [
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Plasmin inhibitor interactions. The effectiveness of alpha2-plasmin inhibitor in the presence of alpha2-macroglobulin. | alpha2-Plasmin inhibitor and alpha2-macroglobulin were allowed to compete for the protease plasmin. The binding of the enzyme to these inhibitors was assessed by two different but comparable methods. The interactions were completed in 10 s of incubation, and transfer of plasmin from one inhibitor to the other did not o... | 70,499 | [
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Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent activation of the associated RNase H. | Conditions are described that promote the efficient reverse transcription of most of Rous sarcoma virus (RSV) RNA sequences by avian myeloblastosis virus DNA polymerase in vitro. A detailed analysis of the reverse transcription reaction was carried out using two procedures: in situ analysis of the RNA sequences transcr... | 70,539 | [
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Possible effects of growth hormone on development of acute lymphoblastic leukaemia. | Growth hormone (G.H.) or a G.H.-dependent somatomedin may be involved in the process of acute lymphoblastic leukaemia (A.L.L.). Growth hormone has a trophic effect on lymphoid tissue and also specific receptors on lymphocytes, most probably T cells. Hypophycess. Resting concentrations of G.H. and somatomedin activity a... | 70,647 | [
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Gentamicin-resistant Klebsiella aerogenes in a urological ward. | A gentamicin-resistant strain of Klebsiella aerogenes was isolated from the urine of 17 patients out of 237 admitted to a male urological ward between Jan. 21 and May 9, 1977. The factors most frequently associated with K. aerogenes in the urine were catheterisation and antibiotic therapy. Often the epidemic strain (ty... | 70,654 | [
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... |
Circulating thymic-hormone activity in congenital immunodeficiency. | Circulating thymic-hormone activity was assayed by measuring Thy 1-2 antigen induction on null lymphocytes from athymic mice incubated with human plasma or serum. Plasma from 19 normal children aged under 10 had inductive activity equivalent to 10-6-16-2 ng thymopoitin/ml. Plasma from 15 infants were severe combined im... | 70,687 | [
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Frequency of eye complaints and rashes among patients receiving practolol and propranolol. | Among 71 patients treated with practolol by general practitioners, eye complaints were recorded in the case-notes of 14 (20%) during treatment, compared with 4 (6%) during equal periods before the drug was prescribed. Half the patients with eye complaints also had a rash while receiving practolol. These findings, which... | 70,688 | [
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Hypercapnia during oxygen therapy in acute exacerbations of chronic respiratory failure. Hypothesis revisited. | A modification is proposed to the well-known hypothesis which explains the development of progressive carbon-dioxide retention in patients with acute exacerbations of chronic respiratory failure when they are given supplementary oxygen to breathe. It is suggested that, in these patients, increased production of lactic ... | 70,692 | [
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0.02893599,
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Uses of percutaneous electrical stimulation of the nervous system. | Temporary percutaneous electrical stimulation of peripheral nerves and the spinal cord is a valuable screening technique. This approach will provide a much higher success rate for identifying those patients suitable for a permanently implanted stimulation system. The system appears to be the treatment of choice for ch... | 70,742 | [
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0.13... |
Serum alphafetoprotein in bladder carcinoma. | 112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capable... | 70,770 | [
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... |
[Bronchial carcinoma. Problems and treatment with special reference to radiotherapy (author's transl)]. | With reference to the recent literature, a representation of case-history, therapy and prognosis of bronchial carcinoma is made. Inhalation of tar products by smoking, as well as predominantly occupational dust are the important etiological factors for the increase in bronchial carcinoma. Because of the long occult pro... | 70,793 | [
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0... |
Adjunctive therapy in treatment for head and neck cancer. | Improvement in tumor-free intervals and cure rates of patients with cancer of the head and neck will almost certainly come from utilization of more than one type of treatment in the same patient. For example, in treatment for formidable lesions this might take the form of a short course of preoperative chemotherapy fol... | 70,846 | [
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... |
Alpha-fetoprotein and albumin in experimentally-induced exencephaly in the rat. | Alpha-fetoprotein and albumin were quantified in the sera and amniotic fluids from control, Vitamin A-treated non-exencephalic and Vitamin A-treated exencephalic rat fetuses. Exencephaly was associated with amniotic fluid alpha-fetoprotein concentrations which were significantly elevated over those of Vitamin A-treated... | 70,849 | [
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HLA antigens and myxedema. | In 22 cases of myxedema 22 HLA-A and B antigens were typed. In six out of eight patients with a history of subacute thyroiditis Bw35 antigen was demonstrated, while in none of 14 patients free from this disease in anamnesis could this antigen be found. This difference is statistically significant, and suggests classify... | 70,859 | [
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-0.1014825,
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0.1236245,
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0.07947053,
0.3262355,
0.4613819,
0.02898409,
-0.3766287,
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0.04498438,
-0.0517262,
0.009935645,
-0.01661699,
0.4073614,
0.1398876,
-0.3144824... |
[Cytochemical study of different stages in the life cycle of Toxoplasma gondii. I. Nucleic acids and proteins in endozoites]. | Using the Feulgen technique in addition to the methyl green-pyronin and gallocyanin-chromalum staining, nucleic acids were detected in Toxoplasma gondii of strains SS-119 and RH DNA was revealed in the nuclei of both intracellular and free individuals examined on various days (2--6) after mouse inoculation. A high RNA ... | 70,874 | [
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0.2599621,
0.1659016,
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-... |
[Prenatal diagnosis of genetic defects from the amniotic fluid. Report of experiences]. | 42 pregnancies were monitored by transabdominal amniocentesis followed by karyotyping. Biochemical assays of cultured amniotic fluid cells, 50 analysis of alpha1-fetoprotein and estimations of the number of y-bodies in the amniotic fluid cells was also made. One chromosomal aberration (47, XY, + 18) was found in 13 pre... | 70,907 | [
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0.08021754,
0.451441,
0.2899944,
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Spectral characteristics of metachromatically stained cartilage: effects of enzymatic degradation and dehydration. | When a microspectrophotometer was used to study cartilage, stained metachromatically with Azure A and Safranin O, the following 3 points were made: 1. the absorption maximum of stained cartilage matrix is identical to that reported for solutions of these dyes containing chondroitin sulfate; 2. partial enzymatic degrada... | 70,941 | [
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... |
Characterization of extract of dog hair and dandruff from six different dog breeds by quantitative immunoelectrophoresis. Identification of allergens by crossed radioimmunoelectrophoresis (CRIE). | An extract of mixed dog hair and dandruff from six different dog breeds (alsatian, boxer, collie, poodle, and long-haired and short-haired dachshund) was obtained by mild extraction, centrifugation, dialysis and freeze-drying. Extract of hair and dandruff from the individual dog breeds was obtained in the same way, but... | 70,943 | [
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An in vitro assay for the quantitation of phagocytic cells of different anatomic origin. | The survival of peritoneal exudate macrophages after 3 to 10 days in culture was examined by measuring the numbers of phagocytes per culture. This was determined by letting the cultured cells phagocytize Latex particles. The number of Latex particle-containing cells was taken as a measure of the survival of phagocytes.... | 70,958 | [
0.1601599,
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0.1231584,
... |
Adenocarcinoma of the proximal third of the stomach. Pitfalls in surgical management. | Adenocarcinoma of the proximal third of the stomach is a florid tumor with a high propensity for esophageal extension limphagitic invasion, and hepatic dissemination. Treatment results in 117 consecutive cases indicate that cure rates may be improved by a closer attention to the esophageal margin of resection. | 70,997 | [
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Carcinoma of the pancreas. | Pancreatic carcinoma remains a difficult problem in surgery. High mortality and overall discouraging results of pancreaticoduodenectomy misled some physicians to believe that surgery is ineffective in management of pancreatic carcinoma. Patients with pancreatic carcinoma in two major hospitals from 1963 through 1976 we... | 70,998 | [
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0.1357183,
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Toxicity and bioconcentration of BHC and lindane in selected estuarine animals. | Flow-through, 96-hr bioassays were conducted to determine the acute toxicity of technical BHC and lindane to several estuarine animals. Test animals and their respective 96-hr lindane LC50 values were: mysid (Mysidopsis bahia), 6.3 microgram/L; pink shrimp (Penaeus duorarum), 0.17 microgram/L; grass shrimp (Palaemonete... | 71,023 | [
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0.3145633,
... |
[Relationship between cardiac arrhythmia and elevated concentrations of free fatty acids in plasma after an acute myocardial ischemia in dogs]. | The influence, on the heart rhythm, of an acute myocardial ischemia produced by a coronary occlusion, is studied in ten opened chest dogs. After elevation of plasmatic free fatty acids, the consequence of a second occlusion on the cardiac rhythm is analysed. There is no significant correlation between the appearance of... | 71,034 | [
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... |
[Method of combined detection of nerve fibers and blood vessels in nerve trunks]. | A new method for investigation of neuro-vasal relationships in nerve conductors is proposed based on a combination of the fine injecting of their blood vessels and staining the nerve fibres. The vessels are injected with the chloroform emulsion of finely ground Paris blue (5-10 g per 100 g of solvent). Pieces of nerves... | 71,133 | [
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0.1133... |
Immunological identification of complex proteins resolved by sodium dodecyl sulfate polyacrylamide disc gel electrophoresis. | Immunological identification of an antigen resolved from a protein complex by sodium dodecyl sulfate polyacrylamide gel electrophoresis has been attained. The identification is based on the formation of immunoprecipitin lines after the antigen diffuses laterally from acrylamide gel transverse slices into a surrounding ... | 71,164 | [
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Radiation therapy of carcinoma of gallbladder and biliary tract. | Fourteen patients with carcinoma of the gallbladder of biliary tract were treated with radiation therapy. Some patients received definite palliative benefit and there were several long term survivors. Patients with bile duct carcinomas responded more often (50%) than did those with gallbladder carcinomas (20%). Only on... | 71,193 | [
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The prognostic value of acute phase reactants in patients with neuroblastoma. | As part of a more extensive study of the immune response in children with neuroblastoma, serum immunoglobulin and alpha-glycoprotein levels were measured in 58 patients. Twenty-nine children were studied at diagnosis, 18 at some time during the first 2 years of treatment, and 11 who were apparently cured after treatmen... | 71,194 | [
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... |
Non-cross-resistant combinations in stage IV non-Hodgkin's lymphomas. | Two triple-drug combinations (cyclophosphamide, vincristine, and prednisone [CVP] and adriamycin, bleomycin, and prednisone [ABP]) were randomly tested in 57 consecutive patients with pathologic stage IV non-Hodgkin's lymphoma. No statistical difference was observed in the incidence of complete remission (CR) (48% vs 5... | 71,209 | [
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... |
Team approach to management of non-Hodgkin's lymphomas: past and present. | A detailed review of our results of radiotherapy for stage I and II non-Hodgkin's lymphomas has been presented as background for our current multidisciplinary approach which uses multiple-agent chemotherapy, radiotherapy, and immunotherapy for nodular and diffuse stage I, II, and III lymphomas of the poorly differnetia... | 71,210 | [
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0.1111347,
0.08665164... |
Recording of drug prescriptions in the county of Jämtland, Sweden. III. Drugs presented for blood donors in a 5 year period. | Drug prescriptions in the county of Jämtland, Sweden, have been examined in order to estimate drug exposure of blood donors. During the period 1970-74 a donor group (n = 292) purchased significantly more drugs than non-donors matched for age, sex and residential area in the county. This was true for most drug categorie... | 71,237 | [
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Effect of heat on antigenicity and immunogenicity of the antigenic determinant shared by Haemophilus influenzae type b and Escherichia coli K100. | Escherichia coli K100 produces an antigenic determinant similar to, or identical with, the capsular antigen of Haemophilus influenzae type b. Studies of the effects of heat on the immunogenicity, erythrocyte-modifying capacity, and antigenicity of this cross-reacting antigen (CRA) revealed the following findings. Immun... | 71,269 | [
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... |
Separation of the Moloney leukemia virus-determined cell surface antigen (MCSA) from known virion proteins associated with the cell membrane. | Cell membranes of Moloney lymphoma cells (YAC, of strain A origin) were solubilized by NP40. The antigenicity of the solubilized protein fraction was assayed by inhibition of the corresponding cytotoxic reaction against YAC target cells. The Moloney leukemia virus (MLV)-determined cell surface antigen (MCSA) was detect... | 71,277 | [
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0.176165,
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Peroxidase and pseudoperoxidase reactions in relation to sudanophilia. | A selective staining of hemoglobin in erythroid cell series was achieved by use of Sudan Black B (modified method of Sheehan and Storey) if optimal amount of hydrogen peroxide was added to the staining mixture. The effect of some inhibitory agents (KCN, wet heat, pH) on this staining as well as on the Lepehne's pseudop... | 71,289 | [
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... |
Does diaminobenzidine demonstrate prostaglandin synthetase? A study on polyunsaturated fatty acid-induced DAB oxidation in sheep vesicular glands and rabbit kidney medulla. | A method histochemical localization of prostaglandin synthetase using DAB, potassium cyanide and polyunsaturated fatty acid has been revised. The arachidonic acid-induced DAB oxidation observed in the secretory epithelium of sheep vesicular glands and in collecting tubules as well as intersititial cells of rabbit kidne... | 71,290 | [
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0.129... |
[Alpha fetoprotein and neonatal jaundice. Contribution to the study of a physiopathologic mechanism]. | The increase in the maternal plasma A.F.P. level is due to an hypoxia of the foetus. The prospective study of 851 single pregnancies shows that there is a significant rise in the A.F.P. levels during the last days of the pregnancy if the babies are going to exhibit a so-called physiological jaundice at birth: the decre... | 71,311 | [
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The beta 2-microglobulin content of the cerebrospinal fluid in neurological disease. | Beta 2-Microglobulin levels in the CSF and serum of 125 neurological patients were determined. The concentration of beta 2-microglobulin in CSF and serum is approximately the same, ranging from 0.6--2.3 mg/l. No clear relationship could be found between the CSF beta 2-microglobulin level on the one hand and the total p... | 71,341 | [
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0.3501569,
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0.04476655... |
The coelomocytes of the earthworm Lumbricus terrestris: morphology and phagocytic properties. | The coelomocytes of Lumbricus terrestris have been classified and described, based on Wright's stained preparations and on living cells. The five major categories consist of basophils, acidophils, neutrophils, granulocytes and chloragogen cells. Both the acidophil and chloragogen cell groups contain two subgroups. Gran... | 71,353 | [
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0.1023808,
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Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis. | Virions isolated from warts of 2 siblings with epidermodysplasia verruciformis (EV), a rare disease characterized by the lifelong growth of warty skin tumors containing papova-like virions, were compared to isolates of human papillomavirus (HPV) from 3 pools of plantar and common hand warts. The length of relaxed, circ... | 71,354 | [
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0.05530617,
0.2467266,
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0.100... |
[Effect of chronic exposure to carbon monoxide on the biochemical composition of human blood]. | Protein, lipid and carbohydrate metabolism of men was investigated during their prolonged exposure to a closed atmosphere containing carbon monoxide at a concentration of 20-10 mg/m3. A 30-day exposure of test subjects to carbon monoxide at a concentration of 20-15 mg/m3 caused an increase of albumin, beta-globulins, t... | 71,368 | [
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... |
Key antigenic determinants in regulation of the immune response. | The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A cyanogen bromide peptide of beta-galactosidase, CB2, mimics the suppression seen wit... | 71,736 | [
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0... |
Specific suppression of MLC and CML by anti-idiotypic antibodies in the mouse. | Rabbit antisera directed against idiotypic determinants of alloreactive mouse CBA anti-C57BL/6 T blasts were raised in the following manner: first, a rabbit serum directed against nonspecific CBA blasts cells was prepared by injecting CBA concanavalin A blasts three times at monthly intervals into a rabbit. Second, spe... | 71,758 | [
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-0.07646412,
0.2788841,
-0.1272736,
0.05232571,
-0.3735447,
-0.1616619,
-0.2246493,
0.07409002,
0.398711,
0.02757132,
-0.1040748... |
A new aspect of voiding dynamics: the relationship between flow rate and the frequency of drops in the external urinary stream. | The method of drop spectrometry gives the possibility of registering the instantaneous trend drop frequency and the instantaneous trend flow rate. By plotting the flow rate against the frequency, patterns are obtained which depend on the flow and the elasticity of the external meatus. | 71,776 | [
-0.1098857,
0.1782736,
0.04838781,
-0.04419097,
0.06960284,
-0.2666139,
-0.2622137,
0.07731944,
0.05271744,
-0.03417871,
0.0497272,
0.001809438,
0.110198,
0.1749103,
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-0.2477948,
0.0257809,
-0.03768888,
-0.1169999,
0.3122383,
-0.09484472,
-0.0429916... |
[Comparative characteristics of influenza virus A/USSR/02/76 and swine influenza virus]. | Comparative studies of the biological properties, antigenic structure and ultrastructure of influenza A viruses isolated in the USSR, A/New Jersey/8/76 and A/swine/31 were carried out. Antigenic differences between A/USSR/02/76 and A/swine/31 strains as well as A/New Jersey/8/76 strain were found in the hemagglutinatio... | 71,790 | [
-0.04393781,
-0.114003,
-0.01114213,
-0.1464234,
0.2215915,
-0.06202368,
-0.3050475,
0.1696028,
0.1457684,
0.1284629,
-0.005361838,
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0.1402583,
-0.3020613,
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0.005475463,
0.1123167,
-0.1230156,
0.1133402,
0.3962247,
0.06000433,
-0.401391... |
Isolation of Neisseria meningitidis in urogenital/rectal infections. | In 9 cases (6 men, 3 women) during 1975 we have isolated N. meningitidis from routine samples from urogenital/rectal locations to be examined for gonococci by culture. One of the men harboured meningococci in the rectum, the other 5 in the urethra. Two of the women had meningococci in the cervix and one in the urethra.... | 71,815 | [
-0.2426031,
-0.1554472,
-0.02555644,
-0.1054446,
-0.1783236,
-0.2982621,
-0.3510539,
-0.4878485,
-0.2589391,
0.07034414,
0.2846325,
0.2699389,
0.03261851,
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-0.2128408,
0.1657938,
-0.1700019,
-0.01112593,
0.4276208,
0.3106193,
0.1852716,
... |
In vitro growth of mouse hair root. | Hair roots from mouse dorsal skin continued to grow in culture medium for 10 h or more after isolation. Under observation by time-lapse cinematography, the cultured hair roots appeared to grow downward. We observed both the downward growth of the cultured hair roots as well as the transfer of melanosomes from melanocyt... | 71,824 | [
0.03214305,
-0.6050073,
-0.4519252,
-0.02229959,
0.1665548,
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0.09443744,
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0.1095613,
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0.1350837,
0.002752436,
-0.1476759,
0.4850332,
0.1189799,
-0.0177652,... |
Increased succinate dehydrogenase activity of lymphocytes in eczema. | Succinate dehydrogenase activity has been studied in the peripheral blood lymphocytes from controls and patients with a variety of skin and other diseases. Increased activity has been found in eczematous dermatitis and dermographism, and also in one patient with chronic lymphatic leukemia. Normal levels were found in p... | 71,826 | [
0.2158398,
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-0.1555141,
0.2271216,
-0.1062771,
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0.1398921,
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0.09175958,
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0.0981928,
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0.3214319,
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-0.5197167,
0.1340656,
-0.2138352,
0.2530144,
0.1837145,
0.191193,
0.1715399,
0.150... |
Complement as an essential factor for indirect immunofluorescence in cases of pemphigoid. | Hitherto in the literature no proof has been published of a complement activation on the basement membrane in cases of pemphigoid. In this paper, for the first time, it is demonstrated, even if only in vitro, that complement, whose presence in the region of the basement membrane has long been known, plays an active rol... | 71,828 | [
0.01383469,
-0.3546467,
0.1190515,
0.05818347,
0.1058646,
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0.04192888,
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0.1543216,
-0.1824344,
0.1039838,
0.2019718,
-0.3770223,
0.158565,
-0.1206289,
-0.6124896,
0.1764283,
-0.401429,
-0.04511382,
0.3462577,
0.2757722,
-0.3314017,
0.0... |
An in vitro study of depressed cell-mediated immunity and of T and B lymphocytes in atopic dermatitis. | Lymphocyte transformation tests, E binding(T) rosette assay and immunofluorescent preparations of B cells were studied in patients with atopic dermatitis, and also in healthy controls. Most of the patients were found to have high levels of IgE in serum. The patients were studied both during severe bouts of dermatitis a... | 71,829 | [
0.1199377,
-0.2825813,
-0.1302289,
0.01456918,
-0.02310615,
-0.211578,
-0.1389289,
0.2485533,
-0.1191789,
0.2784297,
0.336024,
0.1527372,
0.08757503,
0.2765338,
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0.02337384,
0.08815514,
0.2903901,
0.005309192,
0.327565,
0.03674052,
0.2158085,
-0.009434706,
-0... |
Hydrocortisone (cortisol) concentration and penetration gradient. | Hydrocortisone (Cortisol) was incorporated into four different ointments at four concentrations (0.1% 0.3%, 1%, and 3%) and the amounts of the drug penetrating from these preparations into the different layers of excised skin were investigated. The effect of removing the horny layer on the penetration was also determin... | 71,836 | [
0.1383966,
-0.03077161,
-0.471325,
-0.0978434,
0.1469739,
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-0.0400261,
0.05310857,
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0.2996331,
-0.3825403,
0.2814131,
0.008426025,
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0.06025124,
0.07478405,
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0.4983998,
0.2039563,
0.1969451,
0.1872636,
... |
Movement of horseradish peroxidase in the cornea, sclera and the anterior uvea. | The anterior chambers of rabbit, monkey and human eyes were perfused with horseradish peroxidase. The perfusion was started immediately after enucleation of the monkey and human eyes, while the rabbit eyes were perfused in situ after the animals had been killed. Comparative results were obtained after 1 h or perfusion ... | 71,844 | [
-0.003911665,
-0.1401163,
-0.2988223,
0.2393064,
-0.2540635,
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0.02365376,
0.163986,
0.2226236,
0.07290102,
0.3798103,
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0.07025681,
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0.2300274,
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-0.6642984,
0.0718632,
0.1982621,
-0.1482134,
0.07418387,
0.2288228,
0.1121909,
0... |
The appearance of the outflow apparatus of the eye after staining with ruthenium red. | The outflow apparatus from adult baboon and rabbit eyes was stained with the inorganic dye ruthenium red. The ruthenium reaction product coated the surface of the trabecular meshwork cells and the canalicular endothelial cells. Deposits also impregnated the various connective tissue elements within the trabeculae and t... | 71,846 | [
-0.01637512,
0.2218202,
-0.2307703,
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-0.153728,
0.3355445,
0.2356984,
-0.06986121,
0.2100562,
0.310822,
0.06151407,
... |
Diagnosis of acute leukemia. Variability of morphologic criteria. | The diagnosis of acute leukemia depends on the morphologic appearance of Romanowsky-stained blast cells. Three commonly used and accepted criteria for distinguishing among blast cells of different acute leukemias are (1) nuclear chromatin pattern, (2) appearance of nucleoli, and (3) nuclear-cytoplasmic ratio. It is som... | 71,855 | [
0.04630254,
0.2173999,
-0.127348,
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0.244132,
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0.2996183,
0.190256,
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0.06445959,
-0.1562187,
0.1391835,
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-0.2592825,
0.04597335,
-0.1026522,
-0.01521782,
0.6449499,
-0.1303604,
0.04972103,
... |
Prevention of mental retardation: the role of medicine. | In the past 100 years striking progress has been made in the prevention of mental retardation. Since mental retardation is a symptom rather than a distinct disease entity, its prevention requires attention to many different areas. Heterozygote detection, specific factors of pregnancy, the current status of newborn scre... | 71,859 | [
-0.1260175,
0.09284597,
0.1711086,
-0.1914951,
0.2065504,
0.0208833,
-0.2986972,
-0.2062517,
0.09326676,
-0.02854014,
0.2855613,
0.3972279,
0.0770578,
0.2836795,
-0.2691699,
0.02986299,
-0.386506,
0.106637,
-0.02361222,
0.0869353,
0.1448738,
0.153228,
-0.2385528,
-0.039... |
[Side effects of antibiotics in patients with thermal burns]. | The possibilities of antibacterial therapy in the clinics of burn diseases has at present decreased because of increasing microflora resistance to antibiotics. This phenomenon is one of the most often causes of antibacterial drug side effects in burn patients. For control of infections complications in burn patients wh... | 71,876 | [
-0.0006655095,
-0.3859469,
-0.4628845,
0.08688267,
-0.05942931,
-0.1461545,
-0.3980208,
-0.1901533,
0.140395,
0.2767745,
-0.1674707,
-0.198466,
0.2598408,
0.05019759,
0.06090835,
-0.067948,
-0.2448781,
-0.1649877,
0.4060634,
0.3178745,
0.562249,
0.3345309,
-0.1023399,
0... |
Characteristics of the immune response in a patient with Whipple's disease. | A patient with Whipple's disease has been studied to examine the effect of antibiotic therapy on the immune status of the patient, and the specific immune response to a cell wall deficient form of an alpha-haemolytic streptococcus (alpha HS) isolated from this patient. T lymphocyte numbers were reduced, and cutaneous a... | 71,895 | [
0.10397,
-0.5134624,
-0.002374818,
-0.267744,
-0.05710546,
-0.1932135,
-0.1183184,
0.1477378,
0.2710414,
0.1684686,
-0.007105238,
0.2127824,
0.0200649,
-0.1421546,
-0.3332366,
0.1150013,
-0.2809909,
-0.3724658,
-0.3894919,
0.2872612,
0.5179027,
-0.1556205,
0.08161519,
-... |
Monocytic differentiation of cluster cells in agar culture of normal human bone marrow. A cytochemical investigation. | A cytochemical investigation was carried out on the cells that make up the clusters forming in agar cultures of normal human bone marrow after 3, 4, and 5 days of incubation. All the clusters were found to comprise young monocytes that were PAS, peroxidase, Sudan Black, and alpha-naphthyl and naphthol-ASD-acetate ester... | 71,925 | [
0.2435366,
-0.0217503,
-0.2215912,
-0.2397233,
-0.04902743,
-0.03930863,
-0.5093491,
0.1370549,
0.01445487,
-0.3693086,
-0.3662475,
0.3686655,
0.0772033,
0.1092041,
-0.3884335,
0.2820569,
-0.5973164,
0.03971259,
0.1119527,
0.4625418,
0.4277855,
0.02880141,
-0.1766639,
-... |
[Induction of transplantable leukemia-like syndromes in mice by administration of antigens and immunostimulants]. | Splenomegaly characterised by myeloid metaplasia was induced in BALB/c mice by the injection of antigens and immunostimulants. In difference from leukemoid reaction, this syndrome was transmissible both by the plasma and by the splenic cells. Small virus-like particles (30--50 nm) were revealed in the plasma, and RNA-c... | 71,928 | [
-0.164541,
-0.05562796,
-0.08261435,
-0.1472843,
0.358118,
-0.2350176,
-0.1644923,
-0.1795338,
-0.04385703,
0.28717,
-0.04969333,
0.09552252,
0.05443801,
0.227489,
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-0.01440193,
-0.2167328,
0.09875447,
0.1892704,
0.2580854,
0.1043268,
-0.03528625,
... |
[Modified Giemsa technique for the study of characteristic chromosomes of leukemic C57Bl mice]. | G-banded karyotypes have been studied in C57Bl control mice and in animals developing leukemia after i.p. injection of acellular extract of spleen or lymph nodes from isologous animals showing radiation induced leukemia. No visible differences could be detected with respect to the number, size and position of the G-ban... | 71,940 | [
-0.04569418,
-0.02249547,
0.06013264,
0.04645102,
0.1296277,
-0.2528288,
-0.1126983,
-0.2184421,
0.1043968,
0.1443071,
-0.01427943,
0.2013284,
-0.02888207,
0.1363643,
-0.8278618,
-0.05376776,
-0.3272999,
0.04034019,
-0.08124933,
0.474755,
0.262834,
0.03882491,
-0.03763602... |
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