title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Effect of the concentration of inducing agent on the output of lymphokines in the guinea pig. | The production of migration inhibition (MIF) and mitogenic (MF) factors by cultured guinea pig lymph node cells was examined as a function of the concentration of antigen or concanavalin A (ConA). Maximum output of MIF was achieved at comparatively low levels of antigen and was equal to the maximum output by ConA. In c... | 786,697 | [
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[Electron microscopic investigation following canine pulmonary transplantation with regard to functional effects (author's transl)]. | The function of alveolar macrophages in correlation with immunological stimulation, consequently also in pulmonary transplantation, are a subject of discussion. In this study the alveolar manifestations of rejection following pulmonary transplantation, are a subject of discussion. In this study the alveolar manifestati... | 786,710 | [
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[Experimental xenogenic immune pancreatitis. --Immunohistological, enzyme histochemical and ultrastructural studies (author's transl)]. | Repeated intraperitoneal injections of anti-mouse pancreas rabbit serum or of anti-mouse pancreas guinea pig serum produce a chronical sclerotizing pancreatitis. This study has the aim to contribute to the further elucidation of the changes which occur in the acinar cells, as well as to the etiology and pathogenesis of... | 786,715 | [
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Prostaglandins as determinants of vascular reactivity. | Prostaglandins are primarily local or tissue hormones that have their effects at, or near to, the site of synthesis. Some blood vessels synthesize prostaglandins intramurally, where their local release influences vascular tone and reactivity. Endogenous prostaglandins (primarily prostaglandin E2 (PGE2) participate in t... | 786,742 | [
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F' plasmids from HfrH and HfrC in recA- Escherichia coli. | We have isolated and characterized a number of clones resulting from matings of HfrH and HfrC cultures of Escherichia coli with auxotrophic recA- E. coli. As in Low's (1968) experiments, the recA- marker prevented integration of F' episomes into the vegetative chromosomes of the host. Both F'H F'C plasmids contained a ... | 786,778 | [
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Mapping of trichodermin resistance in Saccharomyces cerevisiae: a genetic locus for a component of the 60S ribsomal subunit. | Resistance to the protein synthesis inhibitor trichodermin in Saccharomyces cerevisiae has been studied. A single recessive nuclear gene was responsible for resistance. The resistance locus, tcm1 was found to be closely linked (1 centi-morgan) to the locus pet 17 on the right arm of chromosome XV. The mutation to trich... | 786,781 | [
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[Physiological and pathological aging of the brain]. | Also in the old age, the capability for a meaningful arrangement of life is dependent on the functional integrity of the brain. The processes of senile involution occurring physiologically do not exclude such a possibility. In normal aging, the reduction in the number of nerve cells and dendritic spines is small compar... | 786,827 | [
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Comparison of spontaneous and positive-pressure breathing in supine normal subjects. | Distribution of ventilation (V) and perfusion (Q) was studied with 133Xe in eight supine, normal subjects comparing spontaneous breathing (SB) and intermittent positive-pressure breathing (IPPB). Tidal volume, inspiratory flow, and breathing frequency measured during SB were closely matched during automatically trigger... | 786,972 | [
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Employing electric shock with autistic children. A review of the side effects. | The use of electric shock in a punishment paradigm has continued to be a highly controversial issue in the treatment of autistic children. While the experimental literature argues for the effectiveness of the procedure for reducing maladaptive behaviors, some clinicians and researchers have expressed fear of possible n... | 786,974 | [
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Convenient system for multiple screening of microbial carbohydrate metabolism. | A rapid technique for inoculating carbohydrate oxidation and fermentation media is described. This method employs 24-well tissue culture trays and a multi-inoculator. Other applications are discussed. | 787,007 | [
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Comparison of the sensitivity of two methods for isolation of Mycoplasma pneumoniae. | Throat swab specimens from 1,494 Marine Corps recruits were inoculated into vials containing diphasic (broth/agar) mycoplasma medium and also onto PPLO agar plates, which were subsequently overlayed with sheep erythrocytes in saline agar. Strains of Mycoplasma pneumoniae were isolated from 89 (6%) of the specimens by o... | 787,008 | [
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Cutaneous T-cell lymphomas: clues of a skin-thymus interaction. | The common cellular denominator of the neoplastic lymphocytes of the cutaneous lymphomas is the presence of membrane markers of T-cell identity. For this reason these disorders are grouped together as "cutaneous T cell lymphomas". These neoplastic T-cells have a characteristic tissue distribution (preferentially infilt... | 787,435 | [
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Clinical evaluation of tobramycin in urinary tract infections. | Twenty-one patients with urinary tract infections due to Pseudomonas and coli-form bacilli were treated with 80-120 mg of tobramycin per day in two daily doses. Of these patients, 14 (67%) were cured, one improved, three (14%) showed no improvement, and three (14%) showed a substitution of the original pathogen by anot... | 787,448 | [
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Tobramycin sulfate: a summary of worldwide experience from clinical trials. | Tobramycin sulfate, a new bactericidal aminoglycoside antibiotic, has been evaluated in 3,506 patients. Its in vitro activity is similar to that of other aminoglycoside antibiotics, except that it is more active against Pseudomonas aeruginosa. Clincal studies have shown that tobramycin sulfate is well tolerated and eff... | 787,450 | [
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Aspects of the pharmacology and toxicology of tobramycin in animals and humans. | The pharmacology and toxicology of tobramycin in animals and humans are reviewed. After intramuscular and intravenous administration, tobramycin diffuses throughout most body tissues and tissue fluids. Therapeutic concentrations can be obtained by intravitreal or intradural injections. Dogs tolerate intracisternal dose... | 787,452 | [
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Studies on the prolonged bleeding time in von Willebrand's disease. | Three experimental models have been employed to investigate the mechanism of the prolonged bleeding time in patients with von Willebrand's disease (vWd). 1-deamino-8-D-arginine vasopressin (DDAVP), a synthetic analogue of the antidiuretic hormone, was administered to normal volunteers and patients with vWd in order to ... | 787,458 | [
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Abnormal luteinizing hormone response patterns to synthetic gonadotrophin releasing hormone in patients with polycystic ovarian syndrome. | Basal gonadotrophin and sex steroid levels and responses to an intravenous injection of 100 mug gonadotrophin releasing hormone (Gn-RH) have been studied in 15 patients with polycystic ovaries. Mean basal LH concentration was raised and an excessive, exaggerated and prolonged response was observed after Gn-RH treatment... | 787,466 | [
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Role of the general dentist in maxillofacial prosthetics. | Care of oral cancer patients requires the opinions and coordinated efforts of various consultants or therapists functioning as a multidisciplinary team to treat individual patients' physical, social, and economic problems. The modern medical concept of total treatment of the patient must include dentistry. Every dentis... | 787,508 | [
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The use of intraoral cores to repair complete and partial removable prostheses. | A technique has been described for repairing fractured dentures. The procedure entails use of an occlusal core to correctly position the broken pieces of the denture. This technique is also applicable for repair of removable partial dentures as well as complete dentures. When the cause of a fractured prosthesis can be ... | 787,510 | [
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Night medication in rheumatoid arthritis. | The efficacy of indomethacin 100 mg, diazepam 10 mg, and placebo in producing sleep, relieving night pain, and reducing the severity of morning stiffness, was compared in 18 patients in hospital with active classical or definite rheumatoid arthritis.There was no statistically significant difference in the preference of... | 787,518 | [
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Dielectric properties of yeast cells. | Dielectric measurements were made on suspensions of intact yeast cells over a frequency range of 10kHz to 100 MHz. The suspensions showed typical dielectric dispersions, which are considered to be caused by the presence of cytoplasmic membranes with sufficiently low conductivity. Since the conductivity of the cell wall... | 787,528 | [
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Shigellosis from swimming. | In Augsut 1974, 31 of 45 cases of Shigella sonnei infection in Dubuque, Iowa, were traced to swimming in an 8-km stretch of the Mississippi River. Comparison of the first case in each affected family with neighborhood controls showed a significant correlation between swimming and illness (P less than .0001). A signific... | 787,562 | [
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[Plexiglas (PMMA) in the anterior chamber. An experimental study on biological compatibility]. | For six months the anterior chambers of rabbits were examined at regular intervals with the slit-lamp photograph. The reactions of iris, aqueous, and cornea were observed after implanting one PMMA-disc (0.25 mm thickness and 1.5 mm diameter) through a lancet incision. At the place where the disc touched the iris one co... | 787,645 | [
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Expression of the guanine operon of Escherichia coli as analyzed by bacteriophage lambda induced mutations. | Studies were made on two guanine-requiring strains of Escherichia coli isolated independently as a result of insertion of prophage gamma into one of the structural genes of the guanine operon. These mutants do not exhibit any detectable guaB function but express the guaA function constitutively at a low level, presumab... | 787,758 | [
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Modulation of RNA polymerase specificity by ppGpp. | ppGpp alters the initiation specificity of RNA polymerase holoenzyme in vitro in a direction which mimics the stringent response in vivo. The transition temperature for opening rRNA promoters is increased by the nucleotide, that for opening phi80 promoters is unaffected. This implies that RNA polymerase can discriminat... | 787,760 | [
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Relation between drug-induced central nervous system effects and plasma levels of diazepam in man. | Pharmacodynamic effects and plasma levels of diazepam were studied in healthy male volunteers at different dose levels. Responses to diazepam were quantified, using instruments which measured body sway (statometry) and psychomotor performance (stressalyser tests). High dose-related correlations were obtained between dr... | 787,769 | [
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Vitamin C and acute illness in Navajo school children. | To evaluate earlier observations, including our own, showing usefulness of vitamin C for managing the common cold, we performed a double-blind trial of vitamin C versus placebo in 868 children. There was no difference in number becoming ill (133 versus 129), number of episodes (166 versus 159) or mean illness duration ... | 787,788 | [
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Brain monoamines and parkinsonism. | In Parkinson's disease there is a derangement of the metabolism of at least 3 major brain monoamines, namely, dopamine (DA), norepinephrine (NE) and serotonin (5-HT). Of these alterations the severe deficiency of DA in the striatum is most characteristic, being (a) found in Parkinsonian syndromes of any etiology and (b... | 787,796 | [
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Alfred Werner's research in organic stereochemistry. | Although Werner is best known as the founder of coordination chemistry and the systematizer of structural inorganic chemistry, he was trained primarily as an organic chemist, and his interest in organic chemistry continued throughout his entire career. The present article briefly reviews some of Werner's contributions ... | 787,808 | [
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The use of freeze-dried bone in middle-third face advancements. | A considerable quantity of bone is required for grafting in most middle-third face advancements. In many patients, especially children, the additional surgery needed to obtain large quantities of autogenous bone adds considerable time and morbidity to the primary operative procedure. During the past 3 years we have uti... | 787,861 | [
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Pure red cell aplasia. | The so-called pure red cell aplasia or hypoplasia may occur in various instances: 1- Congenital form, usually occuring in childhood; 2-Drug-induced types; 3-The forms associated with thymoma, carcinoma and hypogamma-globulinemia; and 4-As an isolated syndrome. In the etiology of congenital PRCA some immune mechanisms a... | 787,896 | [
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Studies on the infectivity of tropical African strains of Plasmodium falciparum to some southern European vectors of malaria. | Preliminary experiments in Garki, Nigeria, with A. atroparvus from Italy have shown a refractoriness to infection with the local strain of P. falciparum. Comparative studies involving A. labranchiae and two strains of A. atroparvus, all from Italy, and one local strain of A. gambiae species B, were carried out at Kismu... | 787,897 | [
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[Preparation and biological trials of antimalarial sulfa embonates]. | With the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. Six of the seven embonates prepared showed activity against Plasmodiu... | 788,077 | [
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Dapsone in rheumatoid arthritis. | After a preliminary period of observation, 71 patients with consistently active rheumatoid arthritis (RA) were given dapsone 50 mg daily for one week, then 100 mg daily. There was a significant improvement in subjective clinical state and there were significant falls in serum C-reactive protein (CRP) and the ESR; the R... | 788,118 | [
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Antibacterial synergism: a proposal for chemotherapeutic potentiation between trimethoprim and sulfamethoxazole. | Sulfamethoxazole and other sulfa drugs are moderately potent inhibitors of Escherichia coli dihydrofolate reductase. They also significantly potentiate the inhibition of this enzyme by trimethoprim. The molecular basis for inhibition potentiation is the simultaneous binding of trimethoprim and sulfa by the enzyme. This... | 788,154 | [
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Fournier's gangrene of the penis. | Fournier's gangrene is a rare, fulminant, though generally localizaed disease of the scrotum and penis. Three cases are presented in which the sexual practices of the patients may have played a role in the etiology. Hospitalization, parenteral antibiotics, and appropriate surgical treatment are required. | 788,164 | [
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Closure of abdominal incisions with subcutaneous catheters. | Five hundred patients who underwent a variety of major abdominal operations had primary closure of their abdominal incisions. The technique of closure included the use of catheters in the subcutaneous space with suction, except when an antibiotic solution was being instilled every 8 hours of the first 9 days after oper... | 788,206 | [
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Ischemic versus cytotoxic damage in the white graft reaction. Its relationship to hyperacute kidney rejection. | "White" skin grafts on appropriately sensitized allografted mice are ischemic and necrotic. The ischemia occurs because of failure to form anastomoses between host and graft vessels. This failure is not due to altered host vascular function but correlated with obliterative (nonthrombotic, non-necrotizing) changes of gr... | 788,247 | [
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Hair growth cycles and wave patterns in "nude" mice. | Hair growth cycles and waves were studied through five generations of hair growth in C57BL/6Icr "nude" mice. One group of nudes received thymus grafts, a second group was composed of athymid nudes and a third consisted of heterozygous (nu/&) haired littermates. The results showed that hair growth cycles and wave pa... | 788,248 | [
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[Urological complications following renal transplantation (author's transl)]. | Between December 1964 and April 1974, 216 renal transplants were performed on 200 recipients at the University Clinic of the Cantonal Hospital at Zürich. The ureteroneocystostomy was performed in most cases, a pyeloureterostomy being done only five times. 12% of all recipients (24 patients) developed serious urological... | 788,283 | [
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[Contribution on the surgical correction of penile and penoscrotal hypospadias (author's transl)]. | The authors present a modification of the penoscrotal method of operation for the treatment of penile and penoscrotal hypospadias. The operating technique employed by the authors differs from the original method in that the urethra is formed from a strip of skin from the penis and scrotum. The so far good results are s... | 788,289 | [
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Transcanal tympanoplasty: a 15-year report. | The data presented would seem to support the following conclusions: 1. Transcanal tympanoplasty employing connective tissue underlay grafts, ossicular bone prostheses, and avoidance of mastoid exposure, unless irreversible disease is present, seems to meet contemporary standards of efficacy, safety, and long-term stabi... | 788,298 | [
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[Therapeutic problems in status epilepticus (author's transl)]. | A review is given of the present state of knowledge and current concepts of the causative factors involved in, and the pathological mechanisms underlying status epilepticus. A synopsis of the commonly-applied therapeutic methods is presented. A step-wise therapeutic procedure is advised for the different stages of stat... | 788,345 | [
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[Segmental wall movement of the left ventricle in healthy persons and myocardial infarct patients studied by a catheter-less nuclear medical method (camera-cinematography of the heart)]. | Camera-Kinematography is a nearly noninvasive method to investigate regional motion of the myocard, and allows evaluation of the function of the heart. About 20 min after injection of 15-20 mCi of 99mTC-Human-Serum-Albumin, when the tracer is distributed homogenously within the bloodpool, data acquisition starts. Myoca... | 788,387 | [
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Ontogeny of four cell types in fetal rat islets using histochemical techniques. | The pancreas of the fetal rat was collected from the first appearance of the pancreatic bud at 11 days of gestation, and every day thereafter until birth. After birth the neonatal pancreas was collected every day for one week, and at intervals thereafter. Fetal B-cells were stained with Gomori's aldehyde fuchsin at 16 ... | 788,427 | [
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The bactericidal action of benzoic acid and sodium acetate on the gram-negative flora of dialysis fluid. | Benzoic acid in concentrations from 0.18 per cent and upwards exerted a bactericidal action on the gram-negative flora of dialysis fluid at pH 4.75 in vitro. At a concentration of 0.32 per cent, a reduction of 10(5) was obtained with 24 hours. Sulphonamide resistance did not affect the bactericidal action. The killing ... | 788,461 | [
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Electron microscopic immunohistochemical localization of vasopressin and neurophysin in the median eminence of normal and adrenalectomized rats. | Using an immunoperoxidase technique at the ultrastructural level, vasopressin (VP) and neurophysin (NP) were localized in the axons of the median eminence of normal and adrenalectomized rats. Whereas VP and NP were generally found in 150-nm granules in the internal zone of the normal rat median eminence, in the adrenal... | 788,492 | [
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Federal health planning, part 1: legislative background. | U.S. federal health planning legislation is discussed. The Hill-Burton, Comprehensive Health Planning and Regional Medical programs--early legislative initiatives in health planning--are described, and their effectiveness is discussed. | 788,510 | [
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Controlled clinical trial of four 6-month regimens of chemotherapy for pulmonary tuberculosis. Second report. Second East African/British Medical Research Council Study. | A comparison has been made of the relapse rates between 7 and 30 months for four 6-month regimens. Streptomycin plus isoniazid plus rifampicin had a relapse rate of 2 per cent of 171 patients; isoniazid plus rifampicin had a relapse rate of 7 per cent of 164. An initial 2 months of streptomycin, isoniazid, rifampicin, ... | 788,570 | [
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Carcinoma arising in thyroglossal duct remnants. | Papillary adenocarcinoma arising in a thyroglossal cyst is described in a 38-year-old man to make a total of 83 cases in the literature. Most cases appear to be benign thyroglossal duct cysts. The malignant nature of the lesion was recognized only after the permanent pathology sections were reviewed. Paillary carcinoma... | 788,580 | [
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[Empirical research in psychotherapy. Recent studies in the English-language literature]. | Empirical psychotherapeutic research has much progressed in the last teen years. In that field the american-english workers afford a great number of meaningfull studies and papers. Very definite experimental work has been made in subjects like therapeutic situation, therapist ways, patient's reactions and outcome facts... | 788,603 | [
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[Severe epistaxis in hemorrhagic syndromes (excepting Rendu-Osler disease)]. | The existence of a general abnormality in haemostasis causes more copious and protracted haemorrhage but does not, in theory, cause epistaxis. Abnormalities in primary haemostasis are at the root of these serious haemorrhages (thrombocytopenia and Willebrand's disease). Haemophilia is more rarely the trigger for intrac... | 788,610 | [
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Influence of possible disinfectant transfer on Staphylococcus aureus plate counts after agar contact sampling. | Asbestos-vinyl tile floor panels were mopped with three types of chemical disinfectant product, as well as after contact, with the untreated control panel were prepared according to the manufacturer's label instructions. Similar floor panels were inoculated artificially with Staphylococcus aureus. RODAC (replicate orga... | 788,638 | [
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Characterization of microbial isolates from an estuarine ecosystem: relationship of hydrocarbon utilization to ambient hydrocarbon concentrations. | Water collected at 12 sites in the Neuse River estuary of North Carolina was analyzed for total viable counts on three isolation media (Trypticase soy agar [TSA], marine agar 2216, Sabouraud agar) and total hydrocarbons by fluorescence spectroscopy. Counts of 3.9 X 10(1) to 3.8 X 10(3) cells/ml were found for total het... | 788,639 | [
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Application of immunofluorescence to detection of antibody in Leishmania infections. | Indirect immunofluorescence was used for determination of antibody in human cases of cutaneous leishmaniasis, mice infected with Leishmania tropica and guinea pigs infected with L. enriettii. Results indicated that antibody in mice is detectable 23 days after infection with L. tropica. The antibody titre correlates wel... | 788,659 | [
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... |
Relaxation training: effects on the communicative ability of aphasic adults. | A verbal test battery (VTB) of four 15-item tests was administered to 16 aphasic adults following a period of relaxation training and a control period. Results indicate that verbal communication of aphasic persons is positively influenced by relaxation training. Subjects had significantly higher overall VTB scores and ... | 788,675 | [
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... |
Space flight effects on the hemopoietic function of bone marrow of the rat. | The 22-d orbital flight of rats onboard the Cosmos-605 biosatellite was followed by inhibition of erythroblastosis, alteration in the morphology of megakaryocytes, and stimulation of myelopoiesis. These changes returned to normal 27 d postflight. The colony-forming capacity and pattern of differentiation of hemopoietic... | 788,697 | [
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Design of metabolic and enzymic machinery to fit lifestyle and environment. | Biochemical theory, spectacular as its growth has been in the last half-century, finds its experimental basis in a remarkably few organisms. The rat, the ox, the pig, the hen plus a few micro-organisms consitute the primary source of biochemistry's experimental material, while, by contrast, modern systematics estimates... | 788,718 | [
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Preliminary assessment of flutiorex, a new anorectic drug, in man. | 1 The effects of +/--flutiorex, a new anorectic agent, on food intake, the sympathetic nervous system and the central nervous system were compared to those of fenfluramine and a placebo in a double-blind trial involving six healthy volunteers. 2. Flutiorex exerts a singificant anorectic effect and was shown to be appro... | 788,737 | [
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Determination of the optimum dose of subcutaneous salbutamol in asthmatic patients. | Saline and salbutamol (250 mug, 500 mug, 750 mug, and 1000 mug) injections were administered under double-blind conditions to seven chronic stable asthmatic patients. The response on the respiratory system (FEV1, FVC) and cardiovascular system (pulse rate, blood pressure and ECG) was monitored for 3 hours. Increasing t... | 788,745 | [
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Hydrallazine or phentolamine as adjuncts to beta-adrenoceptor blockade/thiazide therapy in hypertension. | Ten patients not maximally controlled on an oxprenolo/cyclopenthiazide regimen for moderately severe hypertension were treated in a double blind crossover trial with either hydrallazine (75-150 mg/day) or phentolamine (60-120 mg/day) or placebo in addition to their other therapy. Additional phentolamine therapy did not... | 788,759 | [
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A trial of brolitene in the treatment of spasticity. | A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6 weeks, using a fixed dose of six tablets (1200 mg brolitene) per day. Clinical assessment failed to show any therapeutic eff... | 788,760 | [
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Alternative pathway complement activation:a possible mechanism inducing skin lesions in benign gonococcal spesis. | In order to elucidate the pathogenesis of the skin lesions in 'benign gonococcal sepsis' direct immunofluorescence of an early macular lesion and routine histopathology of a mature papulopustular lesion in a patient with septic gonococcal dermatitis have been performed. Histopathology of the mature skin lesion revelaed... | 788,766 | [
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Serum prolactin and the suppression of lactation. | Bromocriptine (2 bromo-alpha-ergocryptine), stilboestrol, clomiphene citrate, testosterone propionate and a placebo were given to 75 postpartum women for the suppression of puerperal lactation. An additional 15 women who breast-fed their babies served as a control group. Blood samples were taken for the determination o... | 788,774 | [
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Physical characterization of a ribosomal nucleoprotein complex. | The complex between ribosomal protein L24 and its RNA binding site (that region of the 23S RNA which the protein protects from ribonuclease digestion) has been studied by various physicochemical methods. The RNA is composed of two fragments of about 160 and 140 nucleotides which interact with each other to form the L24... | 788,777 | [
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Changes in rotational motion of a cell-bound fluorophore caused by colicin E1: a study by fluorescence polarization and differential polarized phase fluorometry. | The stationary fluorescence polarization and the differential phase delay of the polarized components of the fluorescence of 1-phenylnaphthylamine in Escherichia coli suspensions were measured before and after addition of colicin E1. Both sets of measurements register an increase in the rotational relaxation time of th... | 788,778 | [
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DNA repair and recovery in Escherichia coli after psoralen and angelicin photosensitization. | The correlation between DNA repair and recovery of biological functions was studied using three wild type strains of Escherichia coli and two skinphotosensitizing furocoumarins, psoralen and angelicin, which are well known specific reagents of the pyrimidine bases of DNA. In addition to mono-adducts psoralen is able to... | 788,785 | [
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Ribosomal subunit entry into polysomes in yeast. | The kinetics of entry of newly synthesized 40 S and 60 S ribosomal subunits into yeast polysomes is described. The entry times for 40 S and 60 S subunits were found to be 3 and 8 min, respectively. The kinetics of entry of 40 S subunits into large polysomes is found to be different from the kinetics of entry of 60 S su... | 788,786 | [
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Effect of antihistamines and chlorpromazine on the calcium-induced hyperpolarization of the Amphiuma red cell membrane. | 1. It has previously been demonstrated that an increase in extracellular Ca2+ conce-tratio- induces a trandient increase in K+ permeability and associated hyperpolarization of the red cell membrane of the giant salamander, Amphiuma meand. This phenomenon is analogous to the Ca2+-induced KCl loss observed in ATP-deplete... | 788,791 | [
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X-ray small-angle studies of the pyruvate dehydrogenase core complex from Escherichia coli K-12. II. Subunit structure of the core complex. | The interpretation of X-ray small-angle data of the pyruvate dehydrogenase core complex from E. coli K-12 reveals the fine structure of the complex. Specific inner surface (7.07-10(-2 A-1), inner surface (7.60 - 10(5) A2), MEAN TRANSVERSAL LENGTH (56.6 A), coherence length (123.5 A), structural factor (1.1), and cohere... | 788,805 | [
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Evaluation of library service to rural physician associate program students. | Medical students participating in the Rural Physician Associate Program in Minnesota enjoy a unique educational experience, but local library resources are not adequate to support the program. To rectify this deficiency a library service program has been initiated, with the computer-based bibliography and photoduplicat... | 788,816 | [
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Respiratory activity as a determinant of radiation survival response. | Respiration is depressed in irradiated bacteria reaching a minimum level in most strains at 1-3 h after exposure when incubated in growth medium. Since a delay in response is observed, direct action on respiratory enzymes is unlikely. The dosage response of respiration varies widely in the strains studied with Do's fro... | 788,873 | [
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Factors influencing survival of children with nonmetastatic neuroblastoma. | A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphocy... | 788,890 | [
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Sequential and combination chemotherapy of advanced gastric cancer. | One hundred and forty-six previously untreated patients with advanced gastric cancer were assigned at random to therapy with the following regimens: 1) Methyl CCNU alone; 2) Methyl CCNU with cyclophosphamide induction; 3) 5-fluorouracil (5-FU) + methyl CCNU; and 4) 5-FU + methyl CCNU with cyclophosphamide induction. Cy... | 788,891 | [
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Mechanism of Bacillus Calmette-Guérin-induced suppression of metastases in a poorly immunogenic fibrosarcoma. | Bacillus Calmette-Guérin (BCG) reduces the rate of spontaneous pulmonary metastases from a poorly immunogenic fibrosarcoma. To be effective, BCG (1 X 10(6) organisms) must be given in admixture with (1 X 10(6)) tumor cells at the time of transplantation. Reduction of metastasis at this dosage of BCG occurs without a ch... | 788,897 | [
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Control of plasma aldosterone in terminal renal failure before and after nephrectomy and after renal transplantation. | In two patients with terminal renal failure the night-day rhythm of plasma aldosterone (PA) renin activity (PRA) and plasma cortisol (PC) were examined before and after bilateral nephrectomy and after renal transplantation. Before nephrectomy changes in abnormally high PA coincided with PC whereas no significant correl... | 788,978 | [
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Radionuclide angiography with 99m technetium-RBCs. | When properly labeled 99mTc-RBCs are injected into a patient, these labeled cells are fairly stable in the circulation thus allowing scintigraphic studies on cardiovascular system. Among various modified techniques published for 99mTc-RBCs labeling, incubation of RBCs with 99mTc pertechnetate then with tin yielded 99mT... | 789,011 | [
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Circadian variation in 5-hydroxytryptamine levels in human blood. | This study investigates, on a circadian basis, the variation in blood serotonin for a group of 64 healthy persons (volunteers of a Bundeswehr-Ausbildungskompanie); a pronounced circadian rhythm of 5-HT has been found. The variation in daily absolute levels is influenced by novelty stress; by this we refer to the stress... | 789,033 | [
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... |
Pancreatic beta cell replication: effects of hexose sugars. | Neonatal rat pancreatic monolayer cultures were utilized to investigate the effects of various hexose sugars on insulin release and beta cell replication. Sugars tested were D-glucose, L-glucose, 3-O-methyl-D-glucose, D-mannose and D-fructose. These agents were added at varying concentrations to a control medium contai... | 789,054 | [
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Control and management of insect populations by chemosterilants. | Chemosterilants, i.e., chemical compounds that interfere with the reproduction potential of sexually reproducing organisms, can be used in three new approaches to insect control. In the sterile-insect release technique, the principal problem is to develop compounds and methods for their application that would not resul... | 789,057 | [
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Coal hydrogenation and environmental health. | Planning of coal hydrogenation processes, such as liquifaction and gasification, requires consideration of public health implications. Commercial plants will require coal quantities greater than or equal to 20,000 tons/day and the large size of these plants calls for careful consideration of the potential health hazard... | 789,066 | [
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Chemistry, biological activity, and uses of formamidine pesticides. | The formamidines, a relatively new group of acaricide-insecticides, are novel both in their range of biological activities and in their mode of action, which is presently unknown. This paper is a review of the historical development, properties, structures, uses, and chemistry of this group of pesticides, with particul... | 789,070 | [
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Properties and actions of bridged diphenyl acaricides. | The properties and actions of the bridged diphenyl acaricides are discussed. These pesticides, which are more or less structurally related to DDT, were the first of the specific acaricides to be developed. They exhibit remarkable properties of specificity, being primarily toxic to phytophagous mites but of very low tox... | 789,071 | [
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Comparative survey on enzyme localization, ultrastructural arrangement and functional organization in the optic tectum of non-mammalian vertegrates. | The histochemical localization of some enzymatic activities is surveyed in the optic tectum of vertebrates from cyclostomes to birds. These data are compared with results arising from ultrastructural and experimental works in order to outline some possible connections between enzyme localization and functional organiza... | 789,106 | [
0.09983141,
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-0.3290769,
-0.4391071,
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-0.2154496,
0.3173848,
0.06808,
0.1709622,
-0.4057568,
-0.08882958,
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-0.3189684,
0.1566896,
-0.6120117,
0.3996308,
0.1421333,
0.1715004,
0.2769489,
0.2585824,
-0.02110836,
-... |
Behavior of the lysosomal system during organ perfusion. An inquiry into the mechanism of hepatic proteolysis. | In this chapter we have attempted to provide some insight into a mechanism(s) of protein degradation in liver which we believe is implicated in the physiological regulation of free amino acid pools. The association we have observed between regulatory effects of insulin and amino acids in the perfused rat liver and phys... | 789,126 | [
-0.04941592,
-0.200882,
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0.07228402,
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0.1312623,
0.1223822,
-0.03486274,
-0.062... |
Secretion of lysosomal enzymes induced by immune complexes and complement. | Immune complexes react with neutrophils and macrophages by way of surface membrane Fc receptors. Alternatively, after fixation of complement, interaction may be with membrane C3b receptors. As a result, phagocytosis is induced. A consequence of this process is the liberation to the extracellular medium of lysosomal con... | 789,129 | [
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0.1833976,
0.1582612,
0.2102454,
0.3509881,
-0.1314899,
-0.030... |
Ultrastructural studies of human acute pancreatitis. | The pancreatic tissue from a patient with acute hemorrhagic necrotizing pancreatitis was studied by routine electron microscopic observation. The remarkable change was the destruction of pancreatic acinar units. 1) The acinar lumen was dilated with filling of fibrillar materials, which occasionally contained degenerate... | 789,168 | [
0.01414329,
0.1893905,
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0.2205033,
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0.05021867,
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0.2662167,
0.02620737,
0.03771805,
... |
[Antimicrobial effectiveness of sisomicin. I: In vitro activity of sisomicin compared with gentamicin, tobramycin, amikacin and kanamycin (author's transl)]. | The aminoglycosides sisomicin, gentamicin, tobramycin, amikacin and kanamycin are highly active against staphylococci including the penicillinase-positive strains. Sisomicin is more effective than amikacin and kanamycin. Mixed infections with staphylococci and Enterobacteriaceae or Pseudomonas aeruginosa are thus on in... | 789,246 | [
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0.2699964,
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0.07575773,
0.3178785,
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0.441... |
Effect of active and passive immunizations with lipid A and salmonella minnesota Re 595 on gram-negative infections in mice. | The capacity of lipid A, a structure common to the lipopolysaccharide cores of all gram-negative bacteria, to serve as an active immunizing agent in mice and to protect these animals against gram-negative infections was investigated. Active immunization experiments were also performed with the Re mutant of Salmonella m... | 789,248 | [
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0.06275848,
0.1481083,
0.3495214,
0.2988654,
0.4028281,
-0.051... |
Colonization of caesarean section babies by Excherichia coli. | Eight babies all delivered by Caesarean section were observed for evidence of colonization by E. coli from birth until discharge from hospital 10 to 14 days later. Faecal specimens were cultured daily for E. coli as were swabs from the rectum, groin, umbilicus, head, hands und mouth. Different serotypes of E. coli were... | 789,249 | [
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-0.2780235,
0.3199308,
0.2982065,
0.10792... |
Double-blind comparison of phlebitis associated with cefazolin and cephalothin. | In a double-blind, crossover study in 28 patients having infections susceptible to cephalosporins (mostly Staphylococcus or Streptococcus), phlebitis developed in twice as many patients (46.4%) receiving intravenous cephalothin within 48 hours, as in patients (21.4%) receiving intravenous cefazolin over the same time p... | 789,268 | [
0.271404,
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0.08128691,
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0.2838397,
0.1182799,
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-0.2018031,
-0.1822492,
0.1736384,
-0.02580239,
-0.02623174,
-0.1093568... |
Salmonella and Aspergillus infections in common loons overwintering in Florida. | During a 5-year period (1970-1975), 190 common loons (Gavia immer) from overwintering populations on the east and west coasts of Florida were examined for evidence of infectious diseases. Salmonella spp (representing 8 serotypes) were isolated from 27 (14%) of the loons, and lesions typical of those produced by Aspergi... | 789,314 | [
-0.304671,
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0.1487814,
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0.2469853,
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-0.5052468,
0.04503736,
0.3020348,
-0.1799858,
-0.03791351,
0.07436322,
-0.22750... |
Regulation of ribonucleic acid synthesis in spheroplasts, cold-shocked cells, and toluene-treated cells of Escherichia coli. | The effects on the stringent control of ribosomal ribonculeic acid synthesis of the removal of cell wall, cold-shock treatment of cells, LiCl treatment of toluene-treated cells, and hypotonic treatment of spheroplasts were examined using Escherichia coli rel+ cells. Neither the removal of cell wall with penicillin or l... | 789,328 | [
0.1518579,
0.0456693,
0.3301278,
0.09337272,
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0.5175509,
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-0.2833965,
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-0.0498938,
0.4690719,
0.08225511,
-0.2148549,
... |
Characterization of the hybridization between purified 16S and 23S ribosomal ribonucleic acid and ribosomal deoxyribonucleic acid from Escherichia coli. | An assay to distinguish specifically between 16S and 23S ribosomal ribonucleic acid (rRNA) has been developed. The assay involves hybridization of radioactive rRNA to deoxyribonucleic acid (DNA) from lambdailv5 transducing phage, which carries an rRNA transcription unit. Radioactive 16S or 23S rRNA can be specifically ... | 789,334 | [
-0.1840469,
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0.03643226,
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0.2601283,
-0.2755425,
0.2182928,
0.4931445,
0.1099846,
0.00694074... |
Growth response of Escherichia coli to nutritional shift-up: immediate division stimulation in slow-growing cells. | When Escherichia coli 15T- cells growing exponentially at 70- to 80-min doubling times are subjected to a nutritional shift-up via glucose addition, cell division continues at the preshift rate for about 70 min (rate maintenance). The same cells growing at doubling times of 120 min or longer, however, begin to divide a... | 789,337 | [
-0.3072706,
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0.08153329,
-0.1098535,
0.1405367,
0.4238135,
0.4198223,
-0.1147723,
... |
Escherichia coli ornithine carbamolytransferase isoenzymes: evolutionary significance and the isolation of lambdaargF and lambdaargI transducing bacteriophages. | Among the Enterobacteriaceae, Escherichia coli K-12 is the only strain known to have two structural genes (argF and argI) for ornithine carbamoyltransferase. The two gene products interact to form a family of four functional isoenzymes, respectively designated FFF, FFI, FII, and III. The FFF and III isoenzymes exhibit ... | 789,338 | [
-0.1069201,
0.2899452,
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0.2211984,
0.1602065,
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0.06624002,
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0.2081954,
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0.1480651,
0.03955266,
0.01205732,
0.2100719,
-0.4915997,
0... |
Cysteine and methionine content of the Escherichia coli ribonucleic acid polymerase subunits. | We describe a procedure that allows cysteine and methionine content to be determined on microgram amounts of partially purified protein. The only requirements are that the protein can be obtained as a pure band after electrophoresis on a polyacrylamide gel and that some data on amino acid content be available. This met... | 789,343 | [
0.06565649,
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0.1228664,
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0.1411889,
0.2761667,
0.394395,
-0.04116321,
-0.190265... |
Iron-requiring mutant of Escherichia coli carrying a deletion in the aroG-nadA region of the chromosome. | A mutant of Escherichia coli K-12 carrying a deletion in the aroG-nadA region of the genome requires a high concentration of iron for growth. The strain is chromium sensitive, and in the presence of citrate lower concentrations of iron support cell growth. The deletion mutant lost a gene between aroG and nadA that is r... | 789,353 | [
-0.1305342,
0.08227247,
0.1207079,
0.4600856,
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0.2170562,
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0.1591262,
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0.02670606,
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0.3716915,
0.1610097,
-0.2660781,
... |
Protoplast formation in Escherichia coli. | A procedure for protoplast formation in Escherichia coli is described. Removal of the cell wall was confirmed by examination of cells in thin-section preparations. | 789,360 | [
0.005488104,
0.00325224,
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0.09319787,
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0.06689144,
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0.1364758,
0.4693426,
0.34975,
0.03234921,... |
Sugar transport. 2nducer exclusion and regulation of the melibiose, maltose, glycerol, and lactose transport systems by the phosphoenolpyruvate:sugar phosphotransferase system. | The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) can repress the synthesis of certain catabolic enzyme systems in Salmonelly typhimurium and Escherichia coli. The present studies are concerned with an explanation of PTS-mediated repression by studying induction of the catabolic systems required f... | 789,370 | [
0.2853701,
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0.119754,
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-0.06124843,
0.4823464,
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-0.2473015,
-0.... |
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