title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Historical notes on computerized axial tomography. | The original experiments on computerized tomography at the Central Research Laboratories of EMI are discussed. Examples trace the history of improvement in definition and process time, leading to results from the first EMI Scanner which was installed in the Atkinson Morley's Hospital in September 1971. | 789,383 | [
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Studies on the mechanism of circus movement in dissociated embryonic cells of a teleost, Oryzias latipes: fine-structural observations. | The fine structure of lobopodia in dissociated embryonic cells of the freshwater fish, Oryzias latipes, was observed with the electron microscope in order to understand the mechanism of the circus movements which they display. Dense material (grandular or fibrillar) is present in the zone between the lobopodium and the... | 789,387 | [
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Improved medium for detecting pigment production by group B streptococci. | The production of pigment which can be used for presumptive identification of group B streptococci is sometimes weak and difficult to observe in Columbia agar stab cultures. A medium which is whiter and affords better visibility of this pigment is described. | 789,396 | [
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Immunological phenomena in the jejunum and serum after reintroduction of dietary gluten in children with treated coeliac disease. | Jejunal mucosal immunoglobulin-containing cells of all three major classes (IgA, IgM, IgG) were increased in coeliac children on gluten-containing diets but only IgM cell numbers were raised in those on gluten-free diets. Patients with subtotal villous atrophy had greater numbers of immunoglobulin-containing cells than... | 789,405 | [
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A brief review of some properties of alpha-methylnorepinephrine. | The research literature can be confusing because of the vast number of nonproprietary names used by various authors for a specific drug. An attempt is made here to clarify the ambiguity regarding the stereoisomer, (-) erythro-alpha-methylnorepinephrine. This agent is used in dentistry as a vasoconstrictor (Neo-Cobefrin... | 789,434 | [
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Ascorbic acid and fractures in children with myelomeningocele. | Ascorbic acid intake of sixty-seven patients with myelomeningocele, ages one through eight years, was evaluated in two groups, fracture and non-fracture, to compare their intake of ascorbic acid from food-plus-supplement, food-only, and supplement-only with the recommended allowances. Intake from food-plus-supplement e... | 789,440 | [
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[High risk factors of breast cancer]. | The authors analyse the various high-risk factors for breast cancer which have been described by many authors and their relative importance and intricacies. Some of these factors are concerned with the age of the patient, some with the time the periods started, some with the time the menopause occured and whether this ... | 789,446 | [
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Cenetic and immunological aspects of litter size in the mouse. | The effects of antigenic differences between mother and fetus on implantation number and on post-implantation mortality were studied. No evidence was found to support the hypothesis that these two measurements were affected by such antigenic differences or by prior immunization of the mother to paternal antigens. | 789,780 | [
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Lamellar ichthyosis: long-term graft studies on congenitally athymic nude mice. | Whole-skin grafts from a patient with lamellar ichthyosis were maintained on athymic nude mice for periods of 6 weeks to 4 months with excellent preservation of all gross and histologic features of the disease. In recombinant grafts composed of lamellar ichthyosis epidermis and normal dermis grown for periods up to 87 ... | 789,781 | [
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Dynamic mini-computer graphics analysis of long-term electrocardiographic tape recordings. | The full graphic capabilities of a minicomputer have been applied to rapid and versatile analysis of long-term electrocardiographic tape recordings. Interfaced to a standard Avionics tape analyzer, the system's multiple display options provide a powerful tool for arrhythmia detection in a reasonable amount of time. Det... | 789,802 | [
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Secretion of luteinizing hormone caused by continuous infusions of luteinizing hormone releasing hormone in the long-term ovariectomized rat: effect of oestrogen pretreatment. | Continuous infusions of luteinizing hormone releasing hormone (LH-RH) into phenobarbitone-treated long-term ovariectomized rats, resulted in patterns of LH secretion which were determined by the blood LH-RH concentration. Infusions of 52 ng LH-RH/h caused steadily increasing ple maintained for the rest of the experimen... | 789,806 | [
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The interrelationship between progesterone and luteinizing hormone during the ovulation cycle of the hen (Gallus domesticus). | The existence of a circadian rhythm in the sensitivity of the hypothalamus of the laying hen to stimulation by progesterone was investigated by injecting 0.5 mg progesterone subcutaneously during the proposed period of maximum insensitivity. Following this treatment increases in plasma concentrations of both LH and pro... | 789,807 | [
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Isolation of rough mutants of Klebsiella aerogenes and their synthesis of polysaccharides. | Two mutants which lacked both capsular and lipopolysaccharide O-antigen polysaccharides were isolated from Klebsiella aerogenes serotype 2 by phage selection; these were designated rough mutants. The polysaccharide fractions solubilized by partial acid hydrolysis of the lipopolysaccharide from both the wild type and mu... | 789,814 | [
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The long term bonding of a polymeric fissure sealant to stannous fluoride treated enamel. | A report is presented of extended studies of tensile bond strength of Nuva Seal to fluoride-treated enamel 1 week, 3 months and 9 months after application. The differences in strength were not statistically significant. The use of stannous fluoride as the topical agent did not lead to any marked evidence of enamel stai... | 789,831 | [
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Marginal leakage with different composite restorative materials in vitro. Effect of cavity design. | In this preliminary study the degree of marginal leakage was assessed for different cavity designs using both ultra violet-curing and self-curing composite restorative materials and sealants. Butt joint restorations placed in etched and sealant primed cavities failed to prevent leakage. Both saucer-shaped and funnel-sh... | 789,832 | [
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Theophylline pharmacokinetics in premature infants with apnea. | The pharmacokinetics of theophylline were examined in eight low-birth-weight infants (gestation: 26-32 weeks: birth-weight: 887-1,480 gm), who received the drug for treatment of primary apnea. The drug was assayed by high pressure liquid chromatography. The final dosage was 1 to 3 mg/kg/6 hour at 25 to 37 days of age. ... | 789,845 | [
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Superconductivity--a possible mechanism for non-thermal biological effects of microwaves. | Recent evidence for high temperature superconductivity in lipids and in a protein and for a role for superconductivity in growth and nerve processes, combined with experimental demonstration of microwave effects on probable superconductive tunneling in carbon films at room temperature, suggest the possibility that non-... | 789,890 | [
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Properties and synthesis of tubulin in neuroblastoma cells. | Cloned neuroblastoma cell lines derived from the spontaneous mouse tumor C-1300 were used to study nerve cell differentiation. Our findings included a) morphologic and electrical differentiation was induced by the addition of dimethyl sulfoxide to the culture medium of some of the neuroblastoma clonal lines; b) a contr... | 789,906 | [
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[Cardiac insufficiency in ischemic heart disease]. | The presented analysis deals with the physiopathological mechanisms of the debelopment of postinfarction cardiac insufficiency and the clinical peculiarities of its manifestations. It is emphasized that the leading cause of cardiac insufficiency consists in a reduction of the contractile function of the left ventricula... | 789,966 | [
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Medical treatment of gastric and duodenal ulcer. | Antacids prove ready if only temporary relief of the symptoms of ulcers. Physicians have been able to increase the rate of healing of gastric ulcers by advising patients to stop smoking and then either admit them to hospital for bed-rest, or use carbenoxolone sodium as an outpatient therapy. The early trials of some ot... | 790,009 | [
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Structure-function relationship: immunologic. | It is suggested that the antigenic site of glucagon for the specific sera is located within the 24-29 section of the molecule and within the 2-23 section for the fully cross-reacting sera. Biologically inactivated glucagon may retain immunoreactivity in spite of the loss of receptor-binding activity. | 790,083 | [
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The role of mitochondria in carbon catabolite repression in yeast. | The role of mitochondria in carbon catabolite repression in Saccharomyces cerevisiae was investigated by comparing normal, respiratory competent (RHO) strains with their mitochondrially inherited, respiratory deficient mutant derivatives (rho). Formation of maltase and invertase was used as an indicator system for the ... | 790,158 | [
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Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions. | We investigated an immunologic mechanism that might explain the apparent "tolerant" state of the mother during pregnancy. Cellular-immune reactivity in vitro to paternal alloantigens was demonstrated in multigravid women by production of lymphocyte migration inhibitory factor. Serum from normal multigravid women contai... | 790,183 | [
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Possible mechanisms of combination effects in chemical carcinogenesis. | In order to understand variations in thresholds to chemical carcinogens, it is important to appreciate, besides the genetic determinants, those many environmental factors which are at play, at all times, modifying the thresholds for chemical carcinogenesis. An understanding of the mechanisms of action of these factors ... | 790,249 | [
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Brass intraocular foreign body: early intervention and combined surgical approach. | The rapid development of suppurative reaction in response to a copper-containing intraocular foreign body disposes the eye to a poor prognosis. An intraocular brass foreign body case involving cornea, iris, lens, vitreous and retina was satisfactorily managed by early foreign body removal and corneal transplantation fo... | 790,251 | [
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The salivary secretions in health and disease. | The potential usefulness of analysis of the salivary secretions in diagnosis and prognosis is beginning to be explored in depth. The preliminary work already undertaken indicates that modern methods applied to this secretion may provide information that is different from that obtained in other body fluids. Saliva is co... | 790,252 | [
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[Polycystic kidney treated by iterative hemodialysis and kidney transplantation. 25 cases]. | Between January 1968 and December 1975, 25 patients (13 men and 12 women) were treated in the dialysis and transplantation unit of the Brugmann Hospital for terminal renal insufficiency secondary to polycystic disease. Nine patients (36%) underwent repeated surgery in order to ensure adequate successful vascular access... | 790,320 | [
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Conversion of beta-galactosidase to a membrane-bound state by gene fusion. | We have isolated a series of strains in which the lacZ gene has been fused to one of the maltose operons, such that the synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) is inducible by maltose. The most frequent event that generates such fusions results in strains in which an intact la... | 790,385 | [
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The functional repressor parts of a tetrameric lac repressor-beta-galactosidase chimaera are organized as dimers. | The chimaeric protein repressor-galactosidase, in which fully active lac repressor is covalently linked to the active enzyme beta-galactosidase, was used as a system for probing the quaternary structure of lac repressor. Electron micrographs revealed repressor-galactosidase to be a tetrameric aggregate. When lac repres... | 790,390 | [
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[New diagnostic strategies in psychiatry by means of video-technique. I. The use of time-blind video analysis for the evaluation of antidepressant drug trials (author's transl)]. | The use of audio-video methods allowed the decrease of subjective factors influencing ratings of psychopathological phenomina. TV-stored interviews, recorded at separate days, may be compared almost simultaneously. In this study a rating of severity of depression was made of patients under antidepressive medication on ... | 790,410 | [
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A double blind comparison of lithium carbonate and ludiomil in the prophylaxis of unipolar affective illness. | A double-blind prospective study was carried out comparing the prophylactic effect of maprotiline and lithium carbonate over a period of 1 year in patients suffering from recurrent affective disorders. The average Affective Morbidity Index was lower, but not significantly so, in patients treated with lithium. A further... | 790,412 | [
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Pitfalls in the measurement of cerebral blood volume with computed tomography. | The use of contrast material and computed tomography (CT) to measure cerebral blood volume (CBV) is valid only if the agent does not egress into cerebral tissue. Since disruption of the blood/brain barrier is common in cerebral disease states, this raises serious doubt as to the validity of this technique. Studies in e... | 790,453 | [
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[Dietotherapy in the diseases of the gastrointestinal tract in infancy (author's transl)]. | The AA are proposing a dietotherapy in the diseases of the gastrointestinal tract in infancy, characterized from acute diarrhoea. A slow hydrolysis product of casein is used for this purpose. The AA after description of the very good results obtained, are calling the attention on the fact that the advantage was realize... | 790,522 | [
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Surface forces in respiratory bronchioles during a first breath-model experiment and some theoretical considerations. | In a physical sense the terminal bronchioles are capillaries, and the air-liquid interface descending through them during the first breath will therefore have a spherical curvature with a radius identical to that of the airway. Air will reach the alveolus if the liquid-coated bronchiolar wall proximal to the air-liquid... | 790,559 | [
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Animal models of peritonitis. | A reproducible animal model of peritonitis has been developed. It uses standard animals, standardized cultures of bacteria and simple techniques. Use of this model would facilitate comparison of data from workers in this field. The use of small rodents permits the use of comparatively large populations for statistical ... | 790,613 | [
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Subclavian artery laceration due to migration of a Hagie pin. | Injuries to subclavian artery are infrequent and usually occur due to gunshot or stab wounds and occasionally by blunt trauma to the chest. An early diagnosis and control of hemorrhage is essential to prevent death which may occur due to exsanguinating hemorrhage. A case of injury to the subclavian artery due to migrat... | 790,622 | [
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A review of the world epidemiology of rabies. | A number of countries throughout the world have been free from rabies for many years; some are reported to have eliminated the disease and in others it has reappeared after variable periods of time. Apart from these minor variations, however, the global distribution of rabies over the last five to ten years appears unc... | 790,669 | [
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Histopathology of rejection in DLA-identical canine orthotopic cardiac allografts. | The process of chronic rejection is the limiting factor in long term survival after cardiac transplantation. As part of a study of this process in experimental orthotopic heart transplantation, morphological changes during the course of rejection are described in DLA-identical beagle littermates, obtained by serial per... | 790,691 | [
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Transfusion-induced malaria from an asymptomatic carrier. | An asymptomatic malaria carrier who satisfied the currently recommended standards and criteria of the American Association of Blood Banks for blood donation was the source of the transfusion-induced malaria in this study. The risk of transfusion-induced malaria remains a very real threat in the United States. Any case ... | 790,686 | [
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Manipulation of allograft immunogenicity by pretreatment of cadaver donors. | The experimental basis forming the rationale for the reduction of allograft immunogenicity prior to transplantation is described. This is based on the hypothesis that ""passenger leucocytes'' are a major immunogenic stimulus in rejection. Donor pretreatment with high doses of methylprednisolone and cyclophosphamide can... | 790,729 | [
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Selective renal angiography: its value in renal transplantation. | To date angiography has been the most precise diagnostic modality for the evaluation of a transplanted kidney. In the immediate postoperative period angiography can clearly demonstrate the integrity of the vascular anastomoses, and in most cases helps to differentiate between acute tubular necrosis and acute rejection.... | 790,734 | [
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Animal, vegetable or cerebral: brains in agricultural production. | Recent developments in brain research seem to have passed unnoticed in veterinary and agricultural circles. Yet they have transformed views on the subject and, Dr Cross argues, made study of the brain mandatory for future advance in animal health and production. | 790,753 | [
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[Immunoglobulin level in herpes gestationis]. | At a patient with herpes gestationis the immunoglobulins IgG, IgA and IgM as well as the proteins albumin, transferrin and coeruloplasmin were determined in the serum. The relation of this illness of pregnancy with immunological factors is in discussion. | 790,844 | [
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[Phagocytosis of enteropathogenic escherichiae of serogroup 0124:K72(B17)]. | Experiments with phagocytosis of E. coli O124 in the macrophage tissue culture demonstrated a different phagocytability of the S- and R-forms of these bacteria determined by their concentration in the medium. The ingestive and digestive capacity depended on the bacterial virulence. Since R-forms of E. coli O124 lost th... | 790,871 | [
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[Distribution of carotenoids in the tissues of high altitude rodents]. | Carotenoid distribution has been investigated in the organs of the ground squirrels Citellus suslicus and C. pygmaeus, as well as of the vole Microtus majori inhabiting high mountain regions. It was shown that with the increase of the altitude of habitat the level of carotenoids in the brain and liver increases in the ... | 790,866 | [
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On the metabolic radioprotection. | The effect of different factors (0.025 mol/l of cysteine, 0.0003 mol/l of iodoacetamide, 0.328 mol/l of hydroxyurea, deprivation of glucose or essential amino acid and uracil from the medium) on the resistance to gamma rays was studied in the cells of E. coli TAU- during the logarithmic phase. The resistance to gamma r... | 790,872 | [
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[Long-term treatment of nasal polyps with beclomethasone dipropionate aerosol. III. Morphological studies and conclusions]. | Morphological studies during the treatment of patients with nasal polyps with beclomethasone dipropionate aerosol for one year showed a trend towards a decrease in the number of eosinophils in nasal smears and falls in the increased concentrations of albumin, IgG and IgE in the nasal secretion. No change in the histolo... | 790,892 | [
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Immunoglobulins and complement in chronic myocardial disease. A myocardial biopsy study. | Autoimmune mechanisms have been suggested to be of significance in chronic myocardial diseases. However, the frequency and importance of these factors are unknown. In the present study, endomyocardial biopsy specimens from 21 patients with chronic myocardial disease have been examined by direct immunofluorescence for t... | 790,898 | [
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Laboratory and clinical evaluation of a new synthetic absorbable suture for ophthalmic surgery. | A new synthetic absorbable suture, a copolymer of two simple hydroxy acids, glycolic acid and lactic acid, was evaluated in a laboratory and clinical study for its usefulness in ophthalmic surgery. The glycolactide was compared with chromic collagen of similar size. The 8/0 glycolactide showed 30% greater initial stren... | 790,910 | [
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The cardiovascular effects of lithium in man. A review of the literature. | The medical literature since 1900 has been reviewed to determine the nature of lithium's cardiovascular effects. In therapeutic doses, lithium produces reversible T wave flattening and inversion in the electrocardiogram: rarely, it may cause sinus node dysfunction or ventricular arrhythmias. Patients with lithium toxic... | 790,953 | [
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Post-transplant malignant lymphoma. Distinctive morphologic features related to its pathogenesis. | Malignant lymphoma developed in two patients after renal transplantation. In both, the central nervous system was involved. Histologic study of the tumors showed that they were composed of a monomorphous proliferation of cells characterized by a large vesicular nucleus, prominent basophilic nucleolus and strongly pyron... | 790,955 | [
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Primary tumors of the mandible. A study of 49 cases. | Forty-nine cases of primary tumors of the mandible have been reviewed. The anatomic location, pathologic features, sites of metastases, survival rates, and treatment methods were evaluated. Lesions studied included ameloblastoma, osteogenic sarcoma, reticulum cell sarcoma, fibrosarcoma, chondrosarcoma, myxosarcoma, epi... | 790,985 | [
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Human oral defenses against gram-negative rods. | Gram-negative rods are unusual pharyngeal isolates in normal man, which suggests the presence of effective oral defense mechanisms against these organisms. To understand this protection better, we studied the elimination of gram-negative rods from the mouth after gargle challenge. Suspensions of Escherichia coli, Klebs... | 791,034 | [
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Observations on laryngeal disease, laryngeal behavior and voice. | This discussion accepted the hypothesis that every laryngeal sound is produced by its unique type of vocal cord vibration. The production of vocal sound is not capricious, it follows certain laws many of which are not known. Research into the behavior of the larynx has produced some interesting and perhaps, useful find... | 791,049 | [
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... |
Tracheostenosis and bronchial abnormalities associated with pulmonary artery sling. | Three patients with aberrant left pulmonary artery (sling artery) are reported to illustrate associated tracheobronchial abnormalities. The clinical picture was that of severe episodic or progressive respiratory distress without dysphagia in early infancy. Striking narrowing of the trachea by complete "ring cartilages,... | 791,050 | [
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Educational training in endoscopy. | An educational training need has developed as a result of the recent rapidly increasing acquisition of endoscopes. This acquisition has been occurring at a rate faster than training programs can acquaint physicians with their use. A Veterans Administration (VA) feasibility study has determined that color television-end... | 791,053 | [
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Kinetics of the actions of tetracyclines on Escherichia coli as studied by microcalorimetry. | Microcalorimetry was used to study the kinetics of the actions of various tetracyclines on a strain of Escherichia coli. Differences in the capacity to suppress the metabolism of this bacterium were observed. When the antibiotic was present from the start of the experiment, a heat production of 2.0 muW/ml was registere... | 791,106 | [
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In vitro comparison of gentamicin, tobramycin, sisomicin, and netilmicin. | The antimicrobial activity of gentamicin, tobramycin, sisomicin, and netilmicin (Sch 20569) was compared against 150 strains of organisms. Netilmicin was shown to be the least effective against Pseudomonas strains but to have slightly better activity against Staphylococcus aureus and Escherichia coli than the other age... | 791,111 | [
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Mercurial toxicity in yeast: evidence for catabolic pathway inhibition. | Evidence that the mechanism of mercurial toxicity is a blockage of catabolic metabolism is presented. Yeast cells (Saccharomyces cerevisiae) were found to cease respiratory activities within 1.5 min of contrast time with culture mercurials (as HgCl2). This cessation was followed by the rapid depletion of endogenous ade... | 791,121 | [
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Auranofin. New oral gold compound for treatment of rheumatoid arthritis. | Eight patients with rheumatoid arthritis were treated with SK & F D-39162 (auranofin), a new oral gold compound which was effective in suppressing adjuvant-induced arthritis in rats. Clinical and humoral parameters were studied during a 3-month period of drug administration followed by a 3-month period under placeb... | 791,161 | [
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Renal transplantation: a twenty-five year experience. | Boston has played a significant role in the development of renal transplantation. In Boston was performed the first successful isograft between identical twins (1954) the first successful allograft between fraternal twins (1959) and the first successful allograft from a cadaveric donor (1962). An immunosuppressive drug... | 791,162 | [
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[Mixed cultures of heterotrophic, sulfate-reducing and sulfur phototrophic bacteria (author's transl)]. | In mixed cultures, carbon and electron sources for Desulfovibrio desulfuricans are excreted by Escherichia coli from glucose fermentation. Desulfovibrio produces substrates for Chlorobium strain. | 791,172 | [
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[Deanol in tardive dyskinesia: a double-blind study (author's transl)]. | Tardive dyskinesia following long-term application of neuroleptics is resistant to treatment. According to the hypothesis of a relative central nervous system acetylcholine lack as the underlying mechanism 20 patients were treated with dimethylaminoethanol (Deanol) in a double-blind study. Deanol is known to be a direc... | 791,197 | [
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Silicone-loop repair of the torn canaliculus. | Internal splinting with silicone tubing is now a well-established principle of lacrimal canaliculus repair, but fixation of the tubing ends is often unsatisfactory. The use of an internal suture allows this tubing to be converted into a small, continuous loop that is inconspicuous, cannot be inadvertently pulled out, a... | 791,211 | [
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Heat treatment of cast restorations. | A survey of commercial dental laboratories in Brisbane indicates that hardening heat treatment of cast restorations, while not always prescribed by the dentist, is performed in most dental laboratories. | 791,219 | [
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Automatic determination of systolic time intervals. | Systolic time intervals (STI), measured non-invasively and during uninterrupted exercise, may contain information about cardiac function. A processing system was developed, which determines STI automatically from 8-sec recordings at each load level. A preprocessing unit provides automatic recording and optimal signal-t... | 791,258 | [
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Cell-mediated immunity in subacute sclerosing panencephalitis. | The cell immune response, in vivo and in vitro, was investigated in eight patients with subacute sclerosing panencephalitis. Although the disease had been diagnosed at different stages and despite the persistently high titers of humoral antibodies, a definite deficiency of cellular immunity, as indicated by skin reacti... | 791,299 | [
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The effect of halothane and thiopentone on ventilatory responses mediated bythe peripheral chemoreceptors in man. | The activity and responsiveness of the peripheral ventilatory chemoreflex were assessed by the transient depression of ventilation following two breaths of oxygen in air-breathing subjects, and the differing times of onset of the ventilatory response to i.v. sodium bicarbonate in subjects breathing either air or oxygen... | 791,311 | [
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The effect of positive end expiratory pressure on lung mechanics and arterial oxygenation after open heart surgery in young children. | The effect of positive end expiratory pressure (PEEP) during mechanical ventilation of the lungs was measured in 10 young children, aged 3 weeks to 30 months, who were being ventilated artificially after cardiopulmonary bypass surgery. Changes in the end-tidal lung volume were measured directly using a jacket plethysmo... | 791,312 | [
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Double-blind trial of labetalol. | 1 A new anti-hypertensive agent (labetalol) with alpha- and beta-adrenoreceptor-blocking properties has been assessed in 30 patients in a general practice. 2 Significant reduction in blood pressure and pulse rate occurred at a dose of 400 mg/d. A further significant reduction in blood pressure but not of pulse rate occ... | 791,329 | [
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The effects of the fenoterol hydrobromide (Partusisten) aerosol on uterine activity and the cardiovascular system. | Fenoterol hydrobromide (Partusisten) aerosol was used in a placebo-controlled, double-blind, double crossover trial to study its effects on oxytocin-induced uterine contractions and the maternal cardiovascular system. The active and placebo aerosols were each administered a total of ten times or twice each in five pati... | 791,351 | [
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Analysis of the kinetics of photoinduced crosslinkage of the protein and RNA components of the Escherichia coli 50 S ribosomal subunit. | The kinetics of photoinduced crosslinkage of the protein and ribosomal RNA components of the Escherichia coli 50 S ribosomal subunit were determined by two-dimensional gel electrophoresis. One group of ribosomal proteins was found to be reactive in the crosslinkage reaction at doses of 254 nm radiation of 2.9 X 10(3) e... | 791,370 | [
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Bacteriological studies of contamination of hydrophilic contact lenses with Staphylococcus epidermitis. | An attempt was made to contaminate hydrophilic contact lens material with Staphylococcus epidermitis. This study was initiated as a result of some clinical investigations which had revealed the presence of coagulase-negative staphylococcal infection in eyes fitted with this type of contact lens. It was though particula... | 791,428 | [
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Endotoxin, bile salts and renal function in obstructive jaundice. | It is generally agreed that there is an increased incidence of postoperative renal failure in patients with obstructive jaundice. The proposition that this may be due to endotoxin, and that the endotoxin may be absorbed from the patient's own bowel flora, has been investigated. The study was conducted in patients and i... | 791,436 | [
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Chemoimmunotherapy of advanced breast cancer: prolongation of remission and survival with BCG. | Forty-five patients with disseminated breast cancer were given a trial of combination chemotherapy consisting of fluorouracil, adriamycin, and cyclophosphamide (FAC) and immunotherapy with BCG given by scarification. The results were compared with those in a comparable group of 44 patients treated with FAC alone immedi... | 791,447 | [
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Observations on occult malignant lymphomas in the skin. | Six patients with malignant cutaneous lymphomas are described to show the diversified clinical patterning that may occur. None of the lesions, which ranged from solid nodules, through inflammatory infiltrative sesions, to gangrene, could be identified as malignant lymphoma at the time these patients sought medical atte... | 791,475 | [
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Types of anticancer agents isolated from plants. | The active compounds which have been isolated from plants and tested in the chemotherapy program of the National Cancer Institute since the inception of the plant program (as part of the Cancer Chemotherapy National Service Center) are listed, classified into types, and discussed in terms of their activity in experimen... | 791,481 | [
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Novel plant-derived tumor inhibitors and their mechanisms of action. | The activity-directed isolation of new tumor inhibitors of plant origin has yielded many novel compounds with significant growth-inhibitory properties. A large proportion of the new compounds contain highly electrophilic functionalities and chemical and biochemical studies are yielding a growing body of evidence to sup... | 791,483 | [
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Thyroiditis in T cell-depleted rats: suppression of the autoallergic response by reconstitution with normal lymphoid cells. | Qualititive, quantitative and functional differences were found in lymphoid cells of female thymectomized and irradiated (Tx-X) PVG/c strain rats as compared to normal females of the same strain. Tx-X rats were lymphopenic and had reduced numbers of cells within spleen and cervical lymph nodes, depressed transformation... | 791,546 | [
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Human sperm antigens and antisperm antibodies. II. Age-related incidence of antisperm antibodies. | Naturally occurring human antisperm antibodies (ASA) detectable by immunofluorescence, were found to have a peak indicence of 90% in both sexes before puberty. Thereafter, the incidence declined to about 60% and persisted through life. This age-related incidence resembled that for foreign and not self antigens. The nat... | 791,547 | [
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T-cell helper response to antigens of Schistosoma mansoni in CBA mice. | It is believed that a T-cell helper response against the schistosome surface is a necessary prerequisite for the development of protective immunity in schistosomiasis. Accordingly, the carrier effect has been used to assay eleven antigenic preparations of Schistosoma mansoni for their helper T-cell priming against surf... | 791,552 | [
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Absorption and metabolism of phenytoin from tablets and capsules. | Crossover studies were conducted to compare plasma levels of phenytoin and urinary throughput of the major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), after ingestion of single 250-mg oral doses as tablets or as capsules. Plasma levels of phenytoin did not differ significantly for the 2 formulations excep... | 791,565 | [
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Double-blind trial of prostaglandin F2alpha and oxytocin in the induction of labour. | In a random double-blind trial in 28 pregnant women at term, labour was induced with either prostaglandin F2alpha or oxytocin given by intravenous infusion. The results showed that prostaglandin F2alpha was as active as oxytocin and induction was successfully carried out in 24 patients; 3 patients had a caesarean secti... | 791,584 | [
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Taking science where the diarrhoea is. | With attack rates exceeding two episodes per year in the young diarrhoea with attendant dehydration is by far the major single killer in the developing world. An invariable accompaniment of the more insidious and chronic protein-energy malnutrition (PEM), diarrhoea is itself an acute form of malnutrition: fluid-electro... | 791,598 | [
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[Zinc oxide-eugenol as dental material (1)]. | Zinc oxide-eugenol cements are considerably better tolerated by tissue than other dental materials. As they alleviate pain and are bacteriostatic and antiseptic, they are well tolerated by patients. The cements are good insulators and possess better sealing properties than zinc phosphate cements. Because of their poor ... | 791,630 | [
0.09848143,
0.4105651,
0.2724764,
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Long-term organ culture of rat anterior pituitary glands. | An organ culture system for neonatal rat anterior pituitary glands has been developed in which cellular integrity and responsiveness to LH releasing hormone (LHRH) are maintained for at least 4 days. Anterior pituitary glands from Sprague-Dawley rats were cultured individually at 37 C in an atmosphere of 95% O2-5% CO2 ... | 791,638 | [
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0.1690883,
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0.4663494,
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... |
Correlation of the pituitary response to synthetic LH-RH to the estradiol levels in anovulatory and ovulatory women. | This paper describes the LH and FSH responses to synthetic LH-RH in 81 anovulatory women and 37 ovulatory women at various estradiol (Ed) levels. Besides, effects of mestranol of releases of LH and FSH in response to LHrh were examined in 4 anovalatory women. Subjects were divided into 3 groups: low Ed group, moderate ... | 791,640 | [
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0.08943142,
0.02774734,
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Active transport by membrane vesicles from anaerobically grown Escherichia coli energized by electron transfer to ferricyanide and chlorate. | Active transport of amino acids by membrane vesicles from Escherichia coli, grown anaerobically on glucose in the presence of nitrate, can be energized under anaerobic conditions by electron transfer in the nitrate respiration system with formate as electron donor and nitrate as acceptor. A high rate of amino acid tran... | 791,648 | [
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0.02547083,
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0.04037296,
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Selective breeding of mice for antibody responsiveness to flagellar and somatic antigens of salmonellae. | Selective breeding has been performed in mice for their high or low antibody responsiveness to Salmonella antigens (Ag). Two noncross-reacting Salmonellae (S. typhimurium and S. oranienburg) have been alternately used to immunize successive generations in order to avoid interference of maternally transmitted antibody. ... | 791,654 | [
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0.03726634,
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0.3984278,
0.145231,
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-... |
Effects of morphine on the turnover of brain catecholamines and serotonin in rats-acute morphine administration. | Morphine increased the rate of brain dopamine (DA) depletion when given before alpha-methyl-p-tyrosine (AMT) or alpha-propyl-dopacetamide, but not when given after AMT. No effect of morphine was found on the rate of depletion of brain noradrenaline (NA) or serotonin (5-HT) after the two synthesis inhibitors. The accumu... | 791,658 | [
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0.01805707,
0.4795346,
0.3957941,
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0.01980115,
0.01838987,
-0.047350... |
[Insulin receptors-a review (author's transl)]. | The first step in insulin action is interaction of the hormone with specific receptors on the plasma membrane of target cells. The receptor site is defined by its functional properties: it binds insulin with a high degree of specificity and affinity; the specific binding sites are finite in number; hormone binding is r... | 791,721 | [
0.03431202,
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0.04122097,
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0.3698171,
0.07713054,
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0.008388484,
0.1361303,
0.5473419,
0.1986127,
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... |
Oxygen transfer rate, respiration and yields in batch and chemostat cultures of Klebsiella aerogenes. | The effect was studied of oxygen supply on the changes in total and specific rate of oxygen consumption by the cells, oxygen transfer rate, saturation concentrations of dissolved oxygen and the yields of batch and continuous cultivations. Experiments were done on the microorganism Klebsiella aerogenes CCM 2318 growing ... | 791,773 | [
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0.1293594,
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0.4217514,
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-0.02528502,
0.1872188,
0.0172932,
-0.06893472... |
[Alrheumum in the daily practice]. | The new antirheumatic drug Ketoprofen (Alrheumun) has been tested by an open trial in 100 out-patients and the activity and tolerance have been evaluated under practice conditions. A daily dose of 3 capsules Alrheumun proved to have a good activity in patients with rheumatoid arthritis, osteoarthrosis and soft tissue c... | 791,783 | [
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0.0648999,
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0.5145304,
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0.2869355,
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0.2173,
0.1676641,
0.03244323,
-0.1156033,
0.13... |
Localization of catalase A in vacuoles of Saccharomyces cerevisiae: evidence for the vacuolar nature of isolated "yeast peroxisomes". | The subcellular distribution of catalase A in the yeast Saccharomyces cerevisiae has been investigated. The enzyme was found to be bound to large particles, whereas most of the activity of catalase T was located in a 38 000 X g supernatant. Under various isolation conditions catalase A always showed a distribution amon... | 791,790 | [
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0.4009811,
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0.5896678,
0.1065438,
0.08353792,
0.2033958,
-0.1260128,
... |
Unification and technical aspects of total t, active t and b lymphocyte rosette assays. | Conditions for rosette formation of human adult T and B lymphocytes with unsensitized and complement coated SRBC respectively, have been examined in this collaborative study. Modified procedures for identifying, by rosette formation, the total T, active T and B-RFC lymphocytes are described. The procedures reported her... | 791,851 | [
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0.2370218,
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0.2127501,
0.01231544,
0.0... |
In vitro growth inhibition of mastitis-causing coliform bacteria by bovine apo-lactoferrin and reversal of inhibition by citrate and high concentrations of apo-lactoferin. | Bovine apo-lactoferrin (apo-Lf) was added to in vitro cultures of eight strains of coliform bacteria associated with bovine mastitis. As little as 0.02 mg of APO-Lf per ml resulted in marked inhibition of growth of all coliforms. Growth inhibition was lost if saturated Lf or iron plus apo-Lf was added to the synthetic ... | 791,866 | [
-0.04408642,
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0.1042994,
0.2823741,
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0.3183281,
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0.5002822,
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-0.06158506,
-0.1232115,
-0.1523973,
0.1146499,
-0.2156388... |
Desoxymethasone: a new topical corticosteroid. | In a double-blind controlled trial, desoxymethasone was compared with betamethasone valerate in 50 patients with bilateral acute dermatitis using a "within patient" type of comparison. The topical efficacy of desoxymethasone was somewhat greater than that of betamethasone valerate. It was well tolerated and produced no... | 791,872 | [
-0.1247638,
-0.005276525,
-0.07215868,
-0.1119998,
0.006523102,
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0.135806,
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0.1022114,
0.2530319,
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0.1340901,
-0.224765,
0.06086741,
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0.3380307,
-0.1674807,... |
Epidemics of Mycoplasma pneumoniae infection in Denmark from 1958 to 1974. | The study is a retrospective and prospective serological investigation of the incidence of Mycoplasma (M.) pneumoniae infection in Denmark during a 17-year period. By least square multiple regression analysis it was shown that four major outbreaks or epidemics had occurred which culminated at regular intervals of four ... | 791,875 | [
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0.06048425,
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-0.06247149,
0.3738487,
0.5162759,
0.1751228,
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0.1177112,
-0.2327081,
0.07912975,
0.06306988,
-0.001598161,
-0.13321... |
The role of denervation in renal transplantation on renal function in the dog. | The role of denervation in renal transplantation on renal function in the dog was assessed in a controlled study. There was no significant difference between innervated and denervated kidney with regard to effective renal plasma flow, glomerular filtration rate, and urinary potassium excretion. However, urinary sodium ... | 791,890 | [
0.01245959,
0.07059384,
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0.03959851,
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0.0702986,
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0.1835929,
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0.01928966,
0.03629746,
0.06421489,
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-0.08323005,
0.2455159,
0.0365701,
... |
Immunofluorescent localization of hepatitis B antigens in chimpanzee tissues. | Three chimpanzee chronic carriers of hepatitis B surface antigen (HBs Ag) were examined by immunofluorescent techniques to determine the localization of HBs Ag and hepatitis B core antigen (HBc Ag) in their tissues. All specimens were quick-frozen in liquid nitrogen and stored at -70degrees until sectioned. Frozen sect... | 791,892 | [
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0.1574308,
0.1552302,
0.1993526,
0.4247643,
-0.2350653,
0.2... |
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