title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Histochemistry of the duodenal glands of the cat and horse. | The duodenal glands of cat and horse were studied using PAS, Alcian blue, dialysed iron, aldehyde fuchsin-Alcian blue and high iron diamine stains. It was found that the duodenal glands of the horse reacted positively to Alcian blue, dialysed iron stains and also took the Alcian blue stain in the combined aldehyde fuch... | 74,185 | [
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Cultural and physiological characteristics of Clostridium botulinum type G and the susceptibility of certain animals to its toxin. | Strain 89 of Clostridium botulinum type G, isolated by Gimenez and Ciccarelli in 1969, was characterized culturally, biochemically, and toxigenically. It was motile, hemolytic asaccharolytic, weakly proteolytic, lipase and lecithinase negative, and it produced acetic, isobutyric, butyric, and isovaleric acids in pepton... | 74,236 | [
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Pemphigus-like antibodies in bullous pemphigoid. | A patient had clinical, histopathologic, and direct immunofluorescent findings compatible with a diagnosis of bullous pemphigoid. In addition, the patient's serum contained pemphigus-like antibodies with different antigenic specificities than true pemphigus antibodies. Absorption of the patient's serum with AB substanc... | 74,239 | [
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The surgical management of total atrioventricular canal lesions. | Between 1969 and 1976 sixteen children have had surgery for total atrioventricular canal lesions at the Royal Children's Hospital, Melbourne. Twelve infants had palliative banding of the main pulmonary artery to control heart failure and prevent the development of pulmonary hypertension, with two hospital deaths (17%) ... | 74,247 | [
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The effects of ionophores on the fluorescence of the cation 3,3'-dipropyloxadicarbocyanine in the presence of pigeon erythrocytes, erythrocyte 'ghosts' or liposomes. | 1. Pigeon erythrocytes, resealed lysed erythrocytes or liposomes derived from erythrocyte lipids were suspended in solutions containing up to 2 micrometer-3,3'-dipropyloxadicarbocyanine iodide. Gramicidin, valinomycin, nigericin or carbonyl cyanide p-trifluoromethoxy-phenylhydrazone, or combinations of these, were used... | 74,249 | [
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[Histamine and serotonin liberation and vascular permeability in a focus of acute aseptic inflammation]. | Degranulation of mast cells of albino rat peritoneal fluid and mesentery of the small intestine and the release of histamine and serotonin in acute aseptic peritonitis began the first minute after the damage and reached their maximum by the 5-th minute; by the 15-th minute the level of free amines did not differ signif... | 74,262 | [
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[Effect of cyngal on gastric secretion in rats]. | The authors studied the influence of gallic salt of cynoglossophin-heliosupin alkaloid (cyngal), extracted from Cynoglossum officinale L. on the gastric secretion of rats. Cyngal proved to stimulate the secretory function of the rat stomach, beginning from the dose of 0.25 mg/kg. This action is explained by the capacit... | 74,263 | [
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The effect of catecholamines on the in vivo and in vitro responses of the cat lung during anaphylaxis. | 1. Anaphylaxis in the lung of cats actively sensitized to Ascaris antigen has been investigated in vivo and in vitro. 2. In vivo there was a 100% increase in airways resistance and a 50% decrease in dynamic lung compliance following intravenous challenge with Ascaris antigen. Prostaglandin F2alpha induced similar chang... | 74,265 | [
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Cellular localization and concentration of bone cyclic nucleotides in response to acute PTE administration. | The cyclic AMP and cyclic GMP concentrations of alveolar bone of control and PTE-treated cats were measured by chemical and immunohistochemical methods. In the PTE-treated animals, alveolar bone osteoblasts stained intensely for cAMP, but very weakly for cGMP; the periodontal ligament (PDL) cells stained for cAMP simil... | 74,278 | [
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Effects of variations in renal function on the clinical pharmacology of bleomycin administered as an iv bolus. | The clinical pharmacology of bleomycin administered as an iv bolus has been studied in a homogeneous group of patients receiving a single regimen containing bleomycin, vinblastine, and cis-dichlorodiammineplatinum (II). These studies demonstrated that in patients with creatinine clearances greater than or equal to 35 m... | 74,282 | [
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[Combined doxorubicin and bleomycin treatment of metastasising thyroid carcinoma: results in 21 patients (author's transl)]. | The effectiveness of combined cytostatic treatment with doxorubicin and bleomycin was analysed in 21 patients with metastasising thyroid carcinoma which had progressed despite both surgical and radiotherapy. Tumour histology (anaplastic carcinoma in 50%), age and general condition of all patients pointed to a poor prog... | 74,313 | [
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Some peculiar changes in the pattern of respiration connected with REM sleep. A preliminary report. | In the course of polygraphic studies of night sleep the authors recorded respiration through the right and left nostrils by means of two thermoelements. They observed a peculiar and unexpected phenomenon: during the REM sleep phase of the 3rd sleep cycle of 4 healthy persons with 6 full night recordings, respiration th... | 74,319 | [
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Ultrastructure of isolated human mast cells during histamine release induced by ionophore A 23187. | In the presence of calcium, the ionophore A 23187 (10(-7) TO 10(-6) M) causes a dose-dependent histamine release from isolated human mast cells. The accompanying degranulation process is characterized by a formation of channels of fused mast cell granules and by an exocytotic extrusion of altered granule material. Simu... | 74,364 | [
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Antigen-, anti-F(ab')2- and anti-IgE-induced histamine release from rat mast cells. | The existence of IgE antibody molecules on peritoneal mast cells from rats immunized with dinitrophenylated ascaris extract was demonstrated by double antibody immunofluorescence staining and by histamine release induced by anti-IgE antibodies. Cross-linking of the IgE molecules, which are fixed to mast cells, by inter... | 74,366 | [
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[Peptidases. I. Histochemical investigations with 2-naphthylamides and hexazonium-p-rosanilin (author's transl)]. | Using fresh frozen (with and without semipermeable membranes), freeze-dried or sections from aldehyde fixed material and hexazotized p-rosaniline for simultaneous coupling more than 20 different unsubstituted or substituted L-amino acid naphthylamides are split especially in the microvilli and/or stereocilia of the sma... | 74,373 | [
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Plasma kallikrein activation and inhibition during typhoid fever. | As an ancillary part of a typhoid fever vaccine study, 10 healthy adult male volunteers (nonimmunized controls) were serially bled 6 days before to 30 days after ingesting 10(5)Salmonella typhi organisms. Five persons developed typhoid fever 6-10 days after challenge, while five remained well. During the febrile illnes... | 74,379 | [
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Particle--lamella complexes in a case of human benign prostate hyperplasia: brief communication. | Particle--lamella complexes (PLC's), described for the first time, were found in glandular epithelial cells of the hyperplastic prostate tissues from a patient with transitional cell carcinoma of the urinary bladder. PLC's observed in this patient were similar to those seen in human hematopoietic neoplastic cells. They... | 74,415 | [
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Demonstration of thymus-leukemia (TL) antigens on mitochondria of lymphoid cells by immunoelectron microscopy. | The presence of thymus-leukemia (TL) antigens on the surfaces of mitochondria isolated from TL+ cells, e.g., RADA 1 leukemia cells, and TL+ normal thymocytes, has been directly demonstrated by immunoelectron microscopy. Reagents used were TL alloantiserum and a hemocyanin conjugate of rabbit antibody to mouse IgG. No h... | 74,453 | [
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Disturbed oxidative metabolism in organic brain syndrome caused by bismuth in skin creams. | Two patients are described with an organic brain syndrome thought to be due to bismuth (Bi) absorbed from a skin cream. Both patients had intellectual impairment and memory loss punctuated by periods of confusion, tremulousness, clumsiness, difficulty in walking, and myoclonic jerks. A similar clinical picture has been... | 74,459 | [
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Variable adherence to normal human urinary-tract epithelial cells of Escherichia coli strains associated with various forms of urinary-tract infection. | The ability to become attached to normal epithelial cells from the urinary tract was much greater in Escherichia coli bacteria isolated from the urine of patients with acute symptomatic pyelonephritis or cystitis than in those isolated from the urine of patients with asymptomatic bacteriuria. Attachment of the bacteria... | 74,461 | [
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Osteomalacia after small-intestinal resection. | Histological examination of bone from 25 patients with small-intestinal resection showed that 9 (36%) had osteomalacia, which was severe in 5 and mild in 4. The serum-alkaline-phosphatase concentration was raised in all patients with severe osteomalacia, but serum calcium, phosphate, and alkaline-phosphatase concentrat... | 74,542 | [
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Rubella infection and diabetes mellitus. | The incidence of diabetes mellitus was increased in patients with congenital rubella. Experimental congenital rubella infection in rabbits caused histological changes in the beta-cells of the pancreatic islets similar to those found in mice made diabetic by the M variant of the encephalomyocarditis virus. It is conclud... | 74,564 | [
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Smoking and industrial pollution, and their effects on menopause and ovarian cancer. | The rodent ovary contains an enzyme system(s) capable of metabolising poly-cyclic aromatic hydrocarbons to reactive electrophilic intermediates known to cause cytotoxicity, mutation, and cancer. If the human ovary contains similar enzyme systems, metabolic activation of environmental chemicals could explain the earlier... | 74,610 | [
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Cholestasis in acute alcoholic liver disease. | 10 of a series of 108 patients with alcoholic liver disease presented with cholestasis associated with non-cirrhotic alcoholic liver disease and without evidence of extrahepatic biliary obstruction. In 7 patients liver histology and the associated conditions presenting as cholestasis were heterogeneous. However, in 3 p... | 74,724 | [
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Peripheral vascular disease in cigarette smokers and impaired hepatic metabolism of lipoprotein remnants. | The metabolism of very-low-density lipoproteins and chylomicrons includes the extrahepatic hydrolysis of their triglycerides by lipoprotein lipase. This results in cholesterol-rich "remnants" which are further metabolised by the liver. There is experimental evidence that in both patients with type-III hyperlipoproteina... | 74,734 | [
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Limitations of audiovisual aids and educational objectives in a clinical clerkship. | The several components of a clinical clerkship were analyzed and correlated with Part II National Board scores and career choice. No positive correlations could be made between fulfilling educational objectives, utilization of audiovisual aids, general satisfaction and the clerkship, and eventual career choice or perfo... | 74,817 | [
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An optoelectronic slide identifier. | An inexpensive optoelectronic slide identifier that uses binary code is described. It can be attached to most automatic projectors and provides for automatic indexing of up to two-hundred and fifty-five different coded slides, while each slide is being projectd. | 74,822 | [
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A technique for the simultaneous staining of both nucleolar organizer regions and kinetochores of human chromosomes with silver. | Pretreatment of human metaphase chromosomes with NaOH at a pH of 8.5, followed by staining with silver nitrate, differentially stains both the nucleolar organizer regions on the 10 acrocentric chromosomes as well as the kinetochore centers on all 46 chromosomes. | 74,868 | [
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0.03574078,
0.01316732,
0.2196462,
0.08359307,
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0.1645459,
-0.1772224,
-0.07626636,
0.5283145,
0.1301619,
0.1822547,
... |
Stabilization and preservation of the antigenic specificity of Trypanosoma (Trypanozoon) brucei variant specific surface antigens by mild fixation techniques. | Living bloodstream trypansomes fixed by suspension in a 1% formalin solution maintain both their morphology and the immunological specificity of their variant specific surface glycoprotein, so allowing precise identification of the variant types present in a trypanosome population by direct or indirect immunofluorescen... | 74,941 | [
0.1575538,
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0.07283513,
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0.274027,
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0.1572739,
-0.2189588... |
[Study of various serum proteins in lung cancer. Immunoglobulins A, G, M, haptoglobin, alpha-1-antitrypsin, alpha-2-macroglobulin]. | A statistical study of the plasma concentration of immunoglobulin, alpha-1-antitrypsin, haptoglobin, and alpha-2-macroglobulin in 153 patients with primary carcinoma of the lung showed a strong increase in alpha-1-antitrypsin, haptoglobin and A and C immunoglobulins, whilst alpha-2-macroglobulin increases very moderate... | 74,964 | [
0.0590404,
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0.085384,
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0.2378258,
0.4366544,
0.2971759,
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-0.2831607,
0.08... |
[Pattern of suspended particles in the air of an urban zone]. | Measurements of suspended particulates have been carried out throughout one year in a fixed station located in a street with medium-high traffic intensity, in a urban area of Rome. Determinations have been made by gravimetric method on samples obtained by filtration through micropores membrane filters. Monthly patterns... | 74,965 | [
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0.2999017,
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0.1643065,
0.1126854,
0.4116325,
0.09977727,
0.0436565... |
Disc-electrophoretic separation of water soluble proteins from scales of different forms of ichthyosis. | In extracts of scales of different forms of ichthyosis, disc-electrophoretic separation of water soluble proteins was performed. Number and position of the protein bands correspond with number and position of the bands of extracts of normal keratin and psoriatic scales. However, in comparison to normal keratin, all exa... | 74,983 | [
-0.03589625,
0.08490146,
0.009657282,
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0.06425463,
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0.1219301,
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0.4472559,
0.2700233,
-0.0935... |
A spectroscopic investigation of the metal binding site of bleomycin A2. The Cu(II) and Zn(II) derivatives. | Using a combination of ultraviolet-visible absorption, 1H NMR and ESR techniques we have established that N(1) of the imidazole and N(1) of the pyrimidine residues of bleomycin A2 bind to Cu(II) and Zn(II). The observations coupled with the earlier results that the alpha-amino group of the alpha-amino carboxamide funct... | 75,023 | [
0.1117055,
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0.2352249,
0.4378632,
0.1138438,
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-0.... |
Zinc uptake by isolated rat liver parenchymal cells. | Primary cultures of rat liver parenchymal cells maintained as a monolayer in serum-free culture medium were used to investigate the characteristics of zinc accumulation in vitro. Liver parenchymal cells accumulated zinc by a temperature-dependent, saturable process that was inhibited by cyanide, azide, oligomycin, N-et... | 75,027 | [
-0.1676783,
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A Golgi study of the hypothalamus of actinopterygii. | The preoptic area of a primitive actinopterygian, the polypteriform, Calamoichthys calabaricus Smithi, and of the teleost, Anguilla anguilla L., have been studied by Golgi and other neurohistological and histochemical methods. In the preoptic area two regions can be recognized: a cell rich median region and a lateral o... | 75,069 | [
-0.007946691,
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0.005064187,
0.008358615,
0.6368674,
0.08441459,
0.1127... |
HLA antigen frequencies in allergic bronchopulmonary aspergillosis. | The frequency of HLA antigens in twenty-two Caucasian patients with allergic broncho-pulmonary aspergillosis (ABPA) and sixty-nine unrelated Caucasian controls was determined. The results indicated that there was no increased frequency of a specific HLA antigen in patients with ABPA. Moreover, studies in thirteen famil... | 75,074 | [
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0... |
Spinal evoked potential in the cat: effects of asphyxia, strychnine, cord section and compression. | Averaged evoked potentials to sciatic nerve stimulation and to direct stimulation of the cervical spinal cord were recorded from the dura and skin over the spinal cord and cauda equina in bipolar and common reference leads in cats and compared. Response waveform and conduction characteristics are described. The effects... | 75,092 | [
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0.3494266,
0.1749174,... |
Signal to noise ratio and response variability measurements in single trial evoked potentials. | Techniques were developed for measurement of signal to noise ratio and response variability in single trial evoked potentials. These techniques were extended and verified using a digital computer simulation of signal plus noise trials. When applied to real data the measures appear to have high reliability and to demons... | 75,094 | [
-0.06825761,
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0.1337948,
0.06543165,
0.238627... |
[Recurrence-free phases and survival times in children with cytochemically varying acute lymphatic leukemias. Note on the prognostic evaluation of leukemias]. | The recidive-free phases, survival times and the number of long surviging patients were recorded in 64 children with cytochemically differentiated ALL. A significantly more favourable course of ALL of PAS type could be observed as compared with the undifferentiated type and partially with the esterase type, too. Accord... | 75,131 | [
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0... |
[Geophagia sideropenica]. | The authors describe two cases of geophagia (45 years old mother and her 25 years old daughter). Both suffered from an anaemia of medium degree only (case 1: 3.77 million of erythrocytes, Hb 8.5 g%; case 2: 3.34 million of erythrocytes, Hb 10 g%), there was a serious iron deficiency (46 and 35 microgram % respectively ... | 75,133 | [
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0.308285,
-0.2898017,
0.1793992,
-0.06929397,
0.1606103,
0.1505799... |
[Hepatogenic polyglobulinemias and polycythemias]. | The authors distinguish three kinds of hepatogenous polyglobulia: Polycythaemia caused by Budd-Chiari syndrome, polycythaemia caused by a Mosse syndrome (cirrhosis without liver venous thrombosis) and polyglobulia caused by liver tumours. In all three cases the same mechanism is likely to induce polycythaemia or polygl... | 75,134 | [
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0.1652861,
0.07262091,
0.3400252,
0.189395,
-0.03465397,
-0.0... |
The requirement of specific antibody for the killing of E. coli by the alternate complement pathway in bovine serum. | Experiments using the selective divalent cation chelator, ethylene glycol tetraacetic acid (EGTA) showed that the alternate complement pathway was involved in the bactericidal action of bovine serum on two strains of E. coli. The bactericidal system was shown, in experiments involving EGTA and epsilon-amino caproic aci... | 75,177 | [
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0.08134251,
0.2976119,
0.149814,
-0.1756824,
... |
Specific suppression of the immune response by a factor obtained from spleen cells of mice tolerant to human gamma-globulin. | An antigen-specific suppressive factor was extracted from spleen cells of mice made tolerant by injection of deaggregated human gamma-globulin (HGG). The active material could be prepared from T cells, obtained by passaging spleen cells through an anti-immunoglobulin column, although not from cells adherent to the colu... | 75,224 | [
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0.03521948,
0.4074408,
0.1314209,
0.1154765,
-0.30860... |
On the cross-reactivity of staphylococcal enterotoxins A, B, and C. | Strong cross-reactions were demonstrated for staphylococcal enterotoxins B (SEB) and C1 (SEC1) by antigen-binding capacity and by competitive binding ability. Both SEB and SEC1 combined completely with the heterologous antibody although requiring four times as much antiserum as the homologous enterotoxin and both displ... | 75,229 | [
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0.2095687,
0.1140213,
0.4163087,
0.1279847,
-0.1645053,... |
Electrophysiological recovery after compression ischemia of the rat brain. | Cerebral ischemia of 15 min was produced in rats by increasing intracranial pressure above the systolic blood pressure level by infusing artificial cerebrospinal fluid into the cisterna magna. Pulmonary edema was prevented by blocking the vasomotor response with a ganglioplegic agent, and reducing the fluid load by per... | 75,250 | [
0.2282837,
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0.3714323,
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0.04397458,
0.1019123,
... |
Electrophysiological studies on the "stiff-man" syndrome. | In addition to anamnestic and clinical data electrophysiological and pharmacokinetic investigations may be necessary for the diagnosis of stiff man syndrome. Continuous activity of motor units with superimposed bursts during muscular spasms was found by electromyography in the two patients reported. Rigidity and contin... | 75,257 | [
0.1050608,
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0.3427535,
0.4850181,
0.01877821,
0.1227756,... |
Morphologic and cytochemical comparison of human lymphoblastoid T-cell and B-cell lines: light and electron microscopy. | Human lymphoblastoid cell lines characterized as T- or B-cells by various markers were compared morphologically and cytochemically by light and electron microscopy. Distinct differences in nuclear morphology, amount of cytoplasm, pyroninophilia, and periodic acid-Schiff (PAS) staining enabled us to discriminate between... | 75,268 | [
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0.5329745,
0.1471716,
-0.06685847,
-0... |
Effects of passive antibody in bee venom anaphylaxis. | Twelve patients allergic to honeybees were challenged by injections of bee venom; five responded systemically to the venom, with symptoms ranging from angioedema to respiratory distress. These patients were given intramuscular or intravenous infusions of gamma-globulin obtained from the plasma of hyperimmune beekeepers... | 75,280 | [
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-0.4603312,
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0.04178455,
0.246466,
0.2861771,
0.143991... |
[Quantitative estimation of cationic leukocyte antigen (cla) and lysozyme in leukaemic leukocytes (author's transl)]. | Cationic lysosomal proteins such as cationic leukocyte antigen (CLA) and lysozyme were estimated in leukocyte lysates of acute and chronic leukaemics using quantitative enzymatic and immunoprecipitation techniques. The studies demonstrate that both lysosomal conponents are markers of non-lymphatic leukaemias. Therefore... | 75,285 | [
0.3934654,
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0.04125524,
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-0.04779373,
-0.1401876,
... |
In-vitro synthesis of anti-acetylcholine-receptor antibody by thymic lymphocytes in myasthenia gravis. | Cultures of thymic tissue or thymic lymphocytes from nine patients undergoing thymectomy for myasthenia gravis were examined for evidence of anti-acetylcholine-receptor-antibody synthesis. One of four thymic tissues and three of five thymic lymphocyte preparations synthesised this antibody. | 75,339 | [
0.1154845,
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0... |
A double-blind controlled crossover trial of an antigen-avoidance diet in atopic eczema. | 20 out of 36 children (aged two to eight years) with atopic eczema completed a twelve-week, double-blind, controlled, crossover trial of an egg and cows' milk exclusion diet. During the first and third four-week periods, patients on an egg and cows' milk exclusion diet received a soya-based milk substitute (trial perio... | 75,438 | [
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0.1088383,
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Plasmapheresis in Raynaud's disease. | Understanding of the pathogenesis, clinical course, and treatment of Raynaud's disease is confused and unsatisfactory, and no success in treatment can be promised. Five patients with severe Raynaud's disease, who had not responded to other forms of treatment, were treated by plasmapheresis, which produced a striking im... | 75,444 | [
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0.02740042,
0.... |
Susceptibility to diphtheria. | Schick tests and antitoxin titrations have been carried out to investigate what percentage of individuals in each of 9 small groups were susceptible to diphtheria. Overall, 33% were susceptible: 26% among those below and 44% among those above 35 years of age. These results suggest that about 35% of the population of th... | 75,453 | [
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0.07346915,
0.3287654,
0.1413691,
0.12231,
... |
Amniography in the prenatal diagnosis of neural tube defects. | Amniography for the visualization and confirmation of suspected neural tube defect was performed in 9 midtrimester gravidas. In all cases, amniotic fluid alpha-feto protein (AFP) was abnormally elevated. Four cases of anencephaly and one of spina bifida were demonstrated by amniography. These pregnancies were terminate... | 75,528 | [
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0.3898283,
0.006900726,
-0.1546317,... |
Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. | A tridecamer oligodeoxynucleotide, d(A-A-T-G-G-T-A-A-A-A-T-G-G), which is complementary to reiterated 3'- and 5'-terminal nucleotides of Rous sarcoma virus 35S RNA, is an efficient inhibitor of the translation of proteins specified by the viral RNA in the wheat embryo cell-free system. The inhibition specificity for on... | 75,546 | [
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-0.5977216,
0... |
Immunogenicity of cows' milk in man. (Influence of age and of disease on serum antibodies to five cows' milk proteins). | Passive haemagglutination has been used to measure serum antibodies to the five proteins of cows' milk--bovine serum albumin, bovine gamma-globulin, alpha-lactalbumin, beta-lactoglobulin and casein. Titres of antibodies to these proteins, and a composite cows' milk antibody (CMA) score, have been measured in 1,087 sera... | 75,562 | [
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Mixed lymphocyte culture search for HLA-D homozygous typing cells in the Hungarian inbred population of Ivád. | Six functionally HLA-D homozygous typing cells were identified by a restricted investigation into the Hungarian inbred population of Ivád. These putative HLA-D homozygous typing cells were then tested against a highly selected Scandinavian population sample of 60 individuals previously typed by histocompatibility refer... | 75,586 | [
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HLA and mycobacterial infection: increased frequency of B8 in Japanese leprosy. | A total of 60 leprosy patients, 28 of lepromatous and 32 of tuberculoid form, and 70 active tuberculosis patients was compared with a control of 184 for 34 HLA specificities. The most interesting finding was an increased frequency (10.0%) for HLA-B8 (corrected P = 0.062, relative risk = 20.3) in the leprosy patients as... | 75,590 | [
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Evaluation of the antigen specific to the mycelial phase of Candida albicans in the serodiagnosis of candidiasis. | We demonstrated 2 different antibodies against Candida albicans in patients' sera, the detection rates were proportional to the severity of candidiasis. One antibody was directed toward antigen shared by Candida in both blastospore and mycelial phases and the other was directed against antigen found only in the myceli... | 75,594 | [
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[Use of viscous dye solutions for the vital staining of lymphnodes]. | Animal-experimental and clinical results after applications of viscous solution with Fluorescein-Sodium and Erythrosin for representation of lympho-nodes and lymphatic ducts were published. In the frame of lymphography this application in form of a second infusion becomes possible preoperatively as well as intraoperati... | 75,622 | [
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[Antigenic characteristics and various biological properties of glycoprotein from Neisseria meningitidis of serological group A]. | It was shown that the antigen determining the group specificity of meningococcus belonging to serological group A was of mixed polysaccharide-protein nature. Carbohydrate component is responsible for the interaction with the group-specific antibodies in this antigen. Glycoprotein can be isolated both from the cells and... | 75,626 | [
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Failure to detect circulating IgG or IgM antibodies to basal cell carcinoma by immunofluorescence. | Immunofluorescence techniques failed to reveal evidence of anti-tumour antibody in the sera of patients with basal cell carcinima. Although the presence of such antibodies has previously been associated with the absence of metastasis in malignant melanoma, other explanations for the low metaststic potential of basal ce... | 75,642 | [
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Effect of cyproterone acetate on skin surface lipids. | Skin surface lipids in female patients with acne were examined before and after treatment with the oral contraceptive SH 209 AB (2 mg cyproterone acetate and 0.05 mg ethinyl estradiol) by direct extraction with petrol ether and photometrical determination. A significant reduction in the skin surface lipids was seen, to... | 75,644 | [
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Malignant histiocytosis. Histiocytic medullary reticulosis. | Three cases of malignant histiocytosis occurring in children aged 2 months, 10 months and 14 years, are described. In all children the diagnosis was based on anaemia, granulocytopenia or thrombocytopenia, splenomegaly and marked erythrophagocytosis by bone marrow and lymph node atypical histiocytes. Two children aged 1... | 75,657 | [
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Anti-tumor virus activity of copper-binding drugs. | Several, structurally different, copper-binding ligands can inhibit the RNA-dependent DNA polymerase of Rous sarcoma virus (RSV) and can inactivate the ability of the virus to malignantly transform chick embryo cells. These ligands include the anti-microbial agents, thiosemicarbazones, 8-hydroxyquinolines, isonicotinic... | 75,679 | [
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Inflammation inhibiting properties of rat alphaM foetoprotein (rat-alpha2 macroglobulin), an acute phase reactant. | alphaMFoetoprotein of the rat (rat alpha2macroglobulin) is present in serum during foetal development. After birth, alphaMFP declines rapidly, but the protein returns after injury. The injury we used consisted of skin and muscle incision, laparotomy, BaSO4 i.p. The protein occurs also during liverregeneration, livercar... | 75,682 | [
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Neutral red supravital staining for cellular elements in the semen. | Human seminal fluid besides spermatozoa often contains other cellular elements. A supravital staining method designed to differentiate the above mentioned cellular elements was described. Amongst the spermatogenic cells only spermatocytes were stained with Neutral Red. They displayed two peculiar structures designated ... | 75,699 | [
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An analysis of the problem-solving process of third year medical students. | The recognition of pertinent cues and the use of clinical data generated by Junior medical students has been shown to be inconsistent. | 75,707 | [
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The diagnostic problem in multiple sclerosis (M.S.): two specific laboratory tests. | In the present paper are discussed the diagnostic problems in M.S., there has been difficulty in certain diagnostic on the first modest signs in a proportion perhaps as high as 20% and the absence of a specific and reliable laboratory test has long been felt. This study describes two specific laboratory tests in M.S. T... | 75,734 | [
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Sclerotherapy of bleeding oesophageal varices by means of endoscopy. | From 1.1.1969 up to 1.11.1977, 640 patients with hemorrhage from gastro-oesopheal varices were managed by sclerotherapy of the oesophageal wall. In 90% this method succeeded in stopping hemorrhage or preventing a new bleeding during the next four months. Only 43 patients of the total number were treated because of impe... | 75,791 | [
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Observations on 1,000 Millin prostatectomies. | 1,000 Millin prostatectomies were performed under general anaesthesia and normal conditions of blood pressure (without hypotension) over a period of 6 years. Observations were made as to the blood losses (Davillas and Miliaressis, 1972), the length of hospitalization, the various complications and the death causes in 1... | 75,793 | [
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Prevention of experimental allergic encephalitis in guinea-pigs with spinal cord protein: optimum pretreatment schedules and appraisal of plausible mechanisms. | Pretreatment of Hartley guinea-pigs with three injections of 100 microgram of the purified bovine spinal cord protein, (SCP), protected tham from clinical experimental allergic encephalitis (EAE) when they were subsequently challenged with 50 microgram of purified bovine myelin basic protein (MyBP) in Freund's complete... | 75,839 | [
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Induction of interferon synthesis in mice by fractions from Nocardia. | Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h a... | 75,845 | [
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Possible role of IgG4 in discordant correlations between intracutaneous skin tests and RAST. | Comparison of intracutaneous skin tests and RAST in 2 groups of patients, one consisting of 16 individuals having multiple allergies to pollen, mold and animal dander and the other of 10 patients allergic to mold only, revealed that skin tests were more sensitive than RAST. Skin reactions of 3+ to 4+ were frequently as... | 75,853 | [
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Detection of circulating tumor antigens in mice carrying a highly metastatic pulmonary squamous--cell carcinoma. | Recently we reported that the highly metastatic MSC-10 (mouse squamous carcinoma) is incapable of inducing transplantation immunity. Studies reported here were undertaken to determine whether or not the tumor is devoid of tumor-associated antigen. We found that sera from MSC-10 tumor-bearing mice contain soluble protei... | 75,859 | [
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Cytochemistry of the skin of patients with mucopolysaccharidoses. | The distribution of complex carbohydrates has been investigated at the light and electron microscope levels in sweat glands of normal subjects and patients with Hurler's or Hunter's disease. Normal sweat glands examined with a battery of light microscopic histochemical methods revealed sulphated complex carbohydrate in... | 75,871 | [
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Structural and genetic studies on chicken 7S immunoglobulin allotypes. IV. The presence of an unexpected chicken immunoglobulin heavy chain allotype: subclass or pseudoallele? | Low concentrations of allotypic specificity CS-1.1 were detected in the sera of two inbred chicken lines [University of California, Davis (UCD) 7 and Regional Poultry Research Laboratory 15I4] previously reported to lack this specificity. The CS-1.1 alloantigen in 15I4 chickens has the same specificity as the major all... | 75,924 | [
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Parkinsonism and dementia with acoustic neurinomas. Report of three cases. | Three cases of acoustic neurinoma with parkinsonism and dementia are reported. The characteristics of parkinsonism seen in these cases consisted of the rapid development of symptoms and symmetrical rigidity. In all cases there was a marked enlargement of the ventricular system and transient improvement in their mental ... | 75,963 | [
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Lymphocyte stimulation by acetylcholine receptor in polymyositis. | Lymphocytes of twenty-seven patients with polymyositis were incubated in vitro with cholinergic receptor rich membranes obtained from the electric organs of Torpedo Marmorata. Lymphocytes of polymyositic patients were slightly stimulated; positive responses were present mainly in patients affected from more than a year... | 75,964 | [
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The hygiene standard for chrysotile asbestos. | Previous studies, including the analysis on which the current 2 fibres/cm3 hygiene standard is based, may have underestimated the risk of morbidity or mortality following exposure to low levels of asbestos dust. Accurate dose-response data at levels below 2 fibres/cm3 are unlikely to be available for the foreseeable fu... | 76,030 | [
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Reduction in incidence of rheumatoid arthritis associated with oral contraceptives. Royal College of General Practitioners' Oral Contraception Study. | Analyses of the frequency of reporting of rheumatoid arthritis have been undertaken as part of the continuing major prospective survey of oral contraceptives. The rate of reporting in oral-contraceptive users (takers) is half of the rate in non-users (controls). The rates for ex-takers and controls are not materially d... | 76,118 | [
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Value of bile-acid binding agents in post-vagotomy diarrhoea. | Cholecystectomy increases the incidence of post-vagotomy diarrhoea. The effect of agents which either bind bile acids or prevent their action on the colonic mucosa has been studied in 31 patients with post-vagotomy diarrhoea--15 had had vagotomy and pyloroplasty alone and 16 vagotomy and pyloroplasty and cholecystectom... | 76,170 | [
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Glucose-induced hyperkalaemia: A hazard for diabetics? | The intravenous injection of glucose as a "therapeutic test" in comatose diabetics is reviewed in the light of evidence that it may evoke a paradoxical rise in plasma-potassium in the insulin-deprived diabetic. The plasma-potassium rose promptly after a drink of 50 g glucose in 8 insulin-dependent diabetics who had not... | 76,227 | [
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0.01586869,
0.2978958,
... |
[Complement system in disseminated lupus erythematosus]. | The levels of C3, C4 and CH50 in patients with lupus erythematosus disseminatus (LED) were lower than in the controls. However, although in many patients these levels were below the normal values, there was no statistically significant difference between the two group. The levels are reduced during the acute phases and... | 76,330 | [
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... |
The efficacy of showers for control of ectoparasites of sheep. | Ectoparasites of sheep in Britain include the tick Ixodes ricinus, the blowfly, Lucilia sericata, the ked, Melophagus ovinus and the lice, Damalinia ovis and Linognathus ovillus. The most important ectoparasite, however, is the mite Psoroptes communis ovis which causes sheep scab. This notifiable disease was eradicated... | 76,363 | [
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0.4561926,
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... |
Xanthosis, an abnormal pigmentation of cattle. | Xanthosis is seen in cattle in the abattoir. It is characterised by a dark brown colour of the heart muscle and certain skeletal muscles such as the masseter because of the presence of lipofuscin pigment. In a survey of its prevalence in 1000 cattle of varying breeds xanthosis was identified in about 25 per cent of Ayr... | 76,364 | [
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... |
[Resorption of colostral gamma-globulins and detection of antibodies to Bact. rhusiopathiaesuis, S. cholerasuis and beta-hemolytic Esch. coli in newborn pigs]. | Traced was the resorption of colostral globulins and the production of antibodies against Bacterium rhusiopathiae suis, S. choleraesuis, and beta-hemolytic Escherichia coli organisms in newborn pigs. It was found that in the newborn pigs that had not yet started sucking there were no gamma-globulins and specific antibo... | 76,366 | [
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Immunofluorescence of the skin in allergic diseases: an investigation of patients with contact dermatitis, allergic vasculitis and atopic dermatitis. | Skin biopsies for immunofluorescent studies were taken from patients with contact dermatitis (positive patch tests), atopic dermatitis and allergic vasculitis for comparison with normal-appearing skin from the same patients, and from healthy controls. A variety of deposits of immunoglobulins, complement components and... | 76,388 | [
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Plasma levels of 8-methoxypsoralen and phototoxicity studies during PUVA treatment of psoriasis with meladinin tablets. | A new tablet formulation of 8-methoxypsoralen was used in PUVA treatment for psoriasis. The 8-Mop plasma level showed a maximum at about 1 hour after ingestion (mean values: 1/2 hr, 284 microgram/1; 1 hr, 275 microgram/1; 1 1/2 hr, 198 microgram/1; 2 hrs, 129 microgram/1). Phototoxicity tests showed the optimal time fo... | 76,395 | [
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0.4612307,
0.3884178,
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Chlamydia trachomatis urethritis in men attending a venereal disease clinic: a culture and therapeutic study. | Urethral specimens from 459 male patients attending a venereal disease clinic were studied for presence of Chlamydia trachomatis and Neisseria gonorrhoeae. Of the 459 patients, 362 had symptoms suggestive of urethritis. In these 362, gonorrhoea was diagnosed in 78 (22%), while 88 (24%) harboured C. trachomatis; 15 harb... | 76,400 | [
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0.1028949,
0.1... |
Nerves and nerve endings in the skin of tropical cattle. | The nerves and nerve endings in the skin of tropical cattle were studied using histological and histochemical techniques. Many nerve trunks and fibres were present in the reticular and papillary dermis in both hairy and non-hairy skin sites. In non-hairy skin locations such as the muzzle and lower lip, encapsulated end... | 76,410 | [
0.1126821,
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0.2546418,
0.1590388,
0.08098163,
0... |
Histomorphometric analysis of normal bone from the iliac crest. | Bone specimens from a standardized area of the iliac crest were obtained at autopsy in 105 individuals after sudden unexpected death and at biopsy in 30 living volunteers. Seven micron thick sections of the plastic embedded undecalcified material were produced and stained. The amount of cancellous and cortical bone and... | 76,415 | [
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Interaction of 4'-(9-acridinylamino)methanesulfon-m-anisidide with DNA and inhibition of oncornavirus reverse transcriptase and cellular nucleic acid polymerases. | 4'-(9-Acridinylamino)methanesulphon-m-anisidide (AMSA) (NSC 141549), an acridine derivative with activity against a variety of laboratory tumors in vivo, is presently undergoing Phase 1 clinical evaluation. The interaction of AMSA with DNA and its effects on nucleic acid-polymerizing enzymes were examined in an attempt... | 76,512 | [
-0.4794596,
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0.... |
[Temporal organization of paroxysmal discharges in the child. I. Biotelemetric recordings during wakefulness]. | Based on telemetric recordings performed on 6 children, a study of the time distribution of intra-clinical paroxysmal discharges was carried out. It was tested whether this distribution is stochastic, and if not so, whether is depends upon an internal biological rhythm or upon environmental and behavioural factors. Th... | 76,535 | [
-0.1146198,
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0.2234178,
0.1179511,
0.08052813,
0.1767443,
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A self-powered, preprogrammable, constant current, electronic stimulator for implantation in conscious and unrestrained, small animals. | A completely implantable electronic brain stimulator was designed and constructed using commercially available Complementary Metal Oxide Semiconductor digital, integrated circuits. All stimulation parameters were preprogrammed prior to implantation. They included bipolar pulse width (0.5 msec), constant current intensi... | 76,549 | [
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0.03593134,... |
A new concept of triggering mechanisms of IgE-mediated histamine release. | It is generally accepted that an initial step of reaginic hypersensitivity reactions is a bridging of mast cell--bound IgE antibody molecules by antigen. Since IgE molecules are firmly bound to receptors on mast cells, bridging of cell-bound IgE molecules probably brings receptor molecules into close proximity. A hypot... | 76,642 | [
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0.08518074,
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0.01765029,
0.100156,
0.3004148,
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... |
Mechanism of the antipsychotic effect in the treatment of acute schizophrenia. | In a double-blind trial in which 45 patients with acute schizophrenia took part the alpha-isomer of flupenthixol (which blocks the dopamine receptor) was found to be significantly more effective than both beta-flupenthixol (which does not) and placebo. The drug effect was confined to the "positive" symptoms--delusions,... | 76,797 | [
-0.06975739,
0.0898856,
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0.5949619,
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0.04595577,
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0.195694,
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... |
A life-threatening complication of the infusion pump. | Serious disturbances in respiration and venous return developed in 2 infants in whom infusion into a central vein was controlled by a peristalic pump. The effects were the result of extravasation which led to build-up of pressure in the medistinum. | 76,799 | [
-0.2253872,
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0.2160568,
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Antithrombin-III transfusion in disseminated intravascular coagulation. | Three patients with a severe bleeding disorder and disseminated intravascular coagulation were effectively treated with human antithrombin-III concentrates. This treatment, followed by administration of prothrombin complex and platelet suspensions, resulted in a normal haemostasis, which was maintained during clinical ... | 76,800 | [
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0.3401589,
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0.02954386,
... |
Passive transfer of diabetes mellitus from man to mouse. | Lymphocytes extracted from peripheral-blood samples from each of six patients with newly diagnosed insulin-dependent diabetes mellitus were transplanted into arthymic nude mice. At one or more sampling times (in the thirty-day study) blood sugar was higher in mice which had received lymphocytes from diabetic patients t... | 76,848 | [
-0.2678435,
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0.1227641,
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0.2648279,
0.1312496,
0.1576446,
0.1039362,... |
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