title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations. | End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a smalle... | 71,960 | [
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Effectiveness of methods of teaching dental health to 9- to 10-year-old schoolchildren in the United Kingdom. | Dental health education employing five different teaching methods was given to classes of 9- to 10-year-old schoolchildren. A control class received no teaching. The dental health knowledge of the classes was assessed before teaching, and immediately, 1 week and 3 months after teaching by the use of a questionnaire. Al... | 71,966 | [
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A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. | A double-blind crossover trial of 200 mg flurbiprofen daily and 100 mg indomethacin daily, each given for 2 weeks separated by a 1-week placebo washout period, was carried out in 30 patients with rheumatoid arthritis. The results were analyzed for the 26 patients with complete records. No statistically significant diff... | 71,973 | [
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Flurbiprofen at night. | Three double-blind crossover trials were used to study the effects of single doses of flurbiprofen at night on pain at night, duration of morning stiffness and sleep disturbance in patients with active rheumatoid arthritis. Flurbiprofen (150 mg) was shown to be superior to placebo and 150 mg was no more effective than ... | 71,974 | [
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The interaction of Hoechst 33258 and BrdU substituted DNA in the formation of sister chromatid exchanges. | Sister chromatid exchanges (SCEs) are induced in cultured Chinese hamster cells by treatment with 5-bromodeoxyuridine (BrdU) or with Hoechst 33258 (H33258) plus BrdU. The SCE frequencies depend upon the number of H33258 molecules available per cell (or per base pair) and the number of brdU molecules available per cell,... | 71,978 | [
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Inflammatory cell count and identification in specific duodenitis. (Celiac disease, Whipple's disease and Crohn's disease). Comparison with jejunal findings. | The authors studied the count and identification of inflammatory cells in duodenal biopsies of specific duodenitis. In celiac disease there is an increase of lymphocytes in the epithelial layer, and rich population of plasmacells in the lamina propria of duodenal mucosa. In Whipple's disease the reticulum cell componen... | 71,989 | [
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An improved HRP method for the study of central nervous connections. | The HRP tract-tracing method has been modified by the introduction of cryoprotective agents, thereby allowing the enzymatic reaction to take place at sub-zero temperatures. By using cold temperatures the enzymatic reaction can be better controlled, which in turn makes it possible to "push" the method to its maximum wit... | 72,001 | [
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The influence of immunization on some functions of polymorphonuclear leucocytes in vitro. | Polymorphonuclear leucocytes (PMNL) obtained from immunized guinea pigs possess an affinity to antigen. The guinea pigs were immunized with human serum albumin (HSA) in complete Freund's adjuvant. The ability of PMNL to bind antigen was tested by means of the functional disorders induced by antigen after incubation wit... | 72,003 | [
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[The effect of extracorporeal blood radiotherapy on the peripheral blood T and B-lymphocytes in chronic lymphadenitis]. | B-lymphocytes and T-lymphocytes were determined before and after therapy in 12 patients with chronic lymphatic leukemia (CLL) treated with extracorporal blood radiation (ECIB). There was a significant decrease of B-lymphocytes (p less than 0.001) from 85.3 +/- 6.55% to 71.55 +/- 10.60% by ECIB, whereas no significant c... | 72,022 | [
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[The effect of the AcD-AG stabilizer on the survival time and surface properties of fluid preserved platelet concentrates compared to concentrates from fresh blood]. | In the present investigations the storage effect the AcD-AG stabilizer on thrombocytes is examined. The thrombocytokinetic parameters of 9 fresh blood concentrates and 15 concentrates of AcD-AG plasma containing platelets were determined. Storage time amounted to three days. The results show that storage with AcD-AG is... | 72,028 | [
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Interspecies-, species- and type-specific T antigenic determinants of human papovaviruses (JC and BK) and of Simian virus 40. | Immunofluorescence tests, absorption studies and quantitative analysis by a very sensitive 51Cr microcomplement fixation (CF) technique were used to define the degree of relatedness between the tumor (T) antigens induced by human papovaviruses, strain JC and BK, with simian virus 40(SV40) and mouse polyoma virus (PyV).... | 72,046 | [
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Immunological study of the regulation of cellular arylsulfatase synthesis in Klebsiella aerogenes. | Regulation of cellular arylsulfatase synthesis in Klebsiella aerogenes was analyzed by immunological techniques. Antibody directed against the purified arylsulfatase from K. aerogenes W70 was obtained from rabbits and characterized by immunoelectrophoresis, double-diffusion, quantitative precipitation, and enzyme neutr... | 72,063 | [
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The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. VI. The projection onto longitudinal zones of the paramedian lobule. | Microinjections (30-50 nl) of a horseradish peroxidase (HRP) suspension of 25% (wt./vol.) were made in different folia of the paramedian lobule of cats, and the sites of occurrence of labeled cells in the inferior olive were precisely determined. In each case only a small number of cells are labeled, aggregated in a mi... | 72,081 | [
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Immune responses to vaginal or systemic infection of BALB/c mice with herpes simplex virus type 2. | The temporal relationships among the humoral and cellular immune responses were defined in BALB/c mice after vaginal or systemic infection with herpes simplex virus type 2 (HSV-2). After vaginal infection, mice showed evidence of clinical vaginitis on days 4 to 6 and HSV-2 replication was detected locally in the vagina... | 72,115 | [
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Structural subunits of poliovirus particles by electron microscopy. | Electron microscopy of poliovirus particles and empty capsids under various conditions of specimen deposition and staining visualizes the dissociation products of these particles. The dissociation proceeds in steps; it begins with the expansion of particles and leads to the final product of the dissociation--a cluster ... | 72,129 | [
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The bioavailability of phenytoin. | The bioavailability of three commercial products of phenytoin (Epanutin, sodium salt; Phenhydan, calcium salt; Zentropil, free acid) was studied relative to a standard solution of sodium phenytoin. Each preparation was given for 14 days in a daily dose of 300 mg according to a cross over design. The three brands tested... | 72,133 | [
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Temperature dependence of normal sensory nerve action potentials. | Sensory conduction velocities of normal subjects are increasing linearly with rising temperature. The duration of the compound sensory action potentials recorded from the median nerve at the wrist and elbow shows a negative temperature coefficient. The peak-to-peak amplitude of these potentials increases from 22 degree... | 72,135 | [
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The relationship between histamine secretion and 45calcium uptake by mast cells. | 1. Unstimulated mast cells from the peritoneal cavity of the rat take up (45)Ca: the initial phase of rapid uptake being complete after 1 min incubation of the cells with the isotope. Stimulation of the mast cells with an antigen-antibody reaction, dextran or concanavalin A induces an increase in the uptake of (45)Ca w... | 72,146 | [
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Movement of strontium ions into mast cells and its relationship to the secretory response. | 1. Non-stimulated mast cells take up (89)Sr and (45)Ca. There is a rapid phase of uptake of both labels which is complete in 1 min and the (89)Sr uptake is similar in magnitude to the (45)Ca uptake. A further slower phase of uptake occurs in the period from 1 to 30 min of incubation. The magnitude of this slower phase ... | 72,148 | [
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Oral non-absorbed antibiotics prevent infection in acute non-lymphoblastic leukaemia. | 113 patients being treated for acute non-lymphoblastic leukaemia were investigated to determine the effect of suppression of body microbial flora on prevention of infection. They were randomly allocated to a control group or a group which received non-absorbed antibiotics by mouth and topical applications of cutaneous ... | 72,192 | [
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Morphometric changes in rabbit ventricular myocardium produced by long-term beta-adrenoceptor blockade. | In rabbits long-term beta-adrenoceptor blockade did not cause any change in the morphology of individual organelles in the ventricular myocardium. There were, however, striking and significant changes in their relative distribution: (1) the relative volume of the mitochondria was reduced and was replaced by an equivale... | 72,197 | [
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Immunological events at the surface of basophil granulocytes and mast cells which induce degranulation. | IgE molecules combine with basophil granulocytes and mast cells through the Fc portion and sensitize these cells for reaginic hypersensitivity reactions. The number of receptors for IgE per human basophil granulocyte is estimated to be 40,000 to 100,000 and those on rat mast cells is about 300,000. The binding of IgE w... | 72,408 | [
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Histocompatibility determinants in Israeli Jewish patients with multiple sclerosis. | The distribution of 24 HLA antigens of the A and B loci was investigated in 197 Israeli Jewish patients with multiple sclerosis (MS) from various Jewish ethnic origins including central and eastern Europe, countries bordering the Mediterranean, the Middle East and from native-born Israelis. The results were compared wi... | 72,427 | [
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[Short-term catheterization following electroresection of the prostate and adenomectomy]. | The catheter short-term treatment is used in altogether 500 patients in adenectomy as well as in TUR. Apart from the restoration of regular passage the reduction of the infection of the urinary tract is the most important aim of the surgery of the prostate gland. With the help of the short catheter follow-up treatment ... | 72,465 | [
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[Occurrence of pseudoisocyanine-positive endocrine cells in the midgut of the hamster (Cricelulus griseus) (author's transl)]. | Pseudoisocyanine-reacting cells could be identified in the intestinal glands of the upper duodenum of the hamster (Cricetulus griseus). These cells contain numerous granules as carrier substances of the colouring pigments. Presumable these cells are insulin-producing cells. | 72,477 | [
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Topochemical localization of lipids in dinosaur bone by means of Sudan B black. | A dinosaur bone was examined with the aim to demonstrate in it the presence of lipids and to determine their localization. Ground sections of the bone in question revealed the presence of substances yielding positive reactions on application of a histochemical method used for identification of lipids. Moreover, these s... | 72,479 | [
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NMR observation of gramicidin A' in phosphatidylcholine vesicles. | Dimyristoyl phosphatidylcholine was prepared with perdeuterated hydrocarbon chains and sonicated into bilayer vesicles together with gramicidin A'. The 1H NMR resonance from the tryptophan residues in the gramicidin has a linewidth of approximately 80 Hz, indicating significant local mobility for these residues. Parama... | 72,565 | [
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[Association of chemotherapy and radiotherapy in the treatment of advanced cancer of the head and neck]. | At the Head and Neck and Roentgentherapy Services of Fundaçao Antonio Prudente, São Paulo, Brazil, 38 patients with advanced cancer of the oral cavity and oropharynx, were divided into two groups: the first, submmited to treatment with Bleomycin and Linear Acelerator, and the second to isolated irradiation. Both groups... | 72,576 | [
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-0.1424078,
0.1317666,
0.06625018,
0.3877304,
-0.05233916,
0.07739189,
-0.2451497,
-0.234931,
-0.3009872,
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-0.05305012,
0.1188008,
0.2538109,
0.02651561,
-0.2919515,
-0.1292997,
... |
Electron microscopy of rapid identification of animal viruses in hematoxylin-eosin sections. | Routine hematoxylin-eosin stained, paraffin sections were processed for electron microscopy, using a rapid method for localization of animal viruses. Formalin fixation was effective in preserving DNA as well as RNA viruses, however cellular fine structural details and organelles were not well preserved. The procedure i... | 72,592 | [
0.02342123,
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... |
Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using and indirect immunoperoxidase technique. | An immunohistologic study of 21 patients with germ cell tumors of the testis with measured serum levels of chorionic gonadotropin (HCG) and alpha-feto protein (AFP) was undertaken to correlate the various types of neoplasms with the presence of these tumor markers in the tissue and serum. AFP was demonstrated in mononu... | 72,596 | [
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0.1474241,
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0.154813,
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... |
Specificity of antisera produced against bleomycin. | The specificity of antisera produced in a goat or rabbit for use in bleomycin radioimmunoassay has been examined using competitive experiments employing several bleomycin analogs. These studies demonstrate that the antiserum distinguished alterations in both the nucleus and the terminal structure of the molecule. Remov... | 72,602 | [
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0.00245787,
0.4726512,
0.1517593,
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... |
Localization of gonadotrophic hormones in the dog pituitary gland. A study using immunoenzyme histochemistry and chemical staining. | Using the immunoperoxidase technique and antisera to the specific beta (beta) subunits of FSH and LH1, selective immunochemical staining was localized mostly in the same cell type in the pars distalis and pars tuberalis of the dog pituitary gland. However, some cells were consistently shown to react solely with antiser... | 72,609 | [
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0.01076456,
0.3000892,
0.0403968,
-0.2197737... |
Differential Giemsa staining of sister chromatids after extraction with acids. | Chromosomes of Chinese hamster strain cells were air-dried on slides after BrdU substitution for two or three rounds of replication. The preparations were treated with 20% PCA at 55 degrees C for 20-30 min, or 5N HCl at 55 degrees C for 15-20 min. After staining with Giemsa, unifilarly BrdU-substituted chromatids stain... | 72,637 | [
0.02644725,
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0.2898607,
0.1379071,
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... |
Modification of amygdalo-cortical evoked potentials by kindling and pentetrazol-induced generalized convulsions in cats. | Amygdalo-cortical pathways were studied in control cats, kindled cats and pentetrazol-injected cats by the evoked potential method. An increase in amplitude of suprasylvian cortical evoked potentials to stimulation of the amygdala was observed in the kindled group and in the pentetrazol group. Moreover, evoked potentia... | 72,647 | [
-0.03484206,
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0.250255,
0.3029592,
... |
Serum thyrotropin response to thyrotropin-releasing hormone and free thyroid hormone indices in patients with familial thyroxine-binding globulin deficiency. | The response in serum thyrotropin (TSH) to synthetic thyrotropin-releasing hormone (TRH) as well as serum free thyroxine index (FT4I) and free triiodothyronine index (FT3I) was investigated in six patients with familial thyroxine-binding-globulin (TBG) deficiency. The total serum thyroxine (T4) and triiodothyronine (T3... | 72,658 | [
-0.1105999,
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0.1416285,
0.0007222663,
0.1423577,
0.2015695,
0.3553334,
-0.02904912,... |
The possible role of vasoactive substances for the hemodynamic effects of rapidly injected antilymphocyte globulin. | A rapid intravenous injection of ALG into splenectomized dogs induced an almost complete elimination of lymphocytes and an extensive but partly reversible thrombocytopenia during which platelets were trapped in the lung. During this trapping there was a significant decrease in arterial blood pressure, pulmonary blood v... | 72,668 | [
-0.0296947,
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0.335241,
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0.6832432,
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0.2931643,
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... |
Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. IV. Selective tolerance and IgE response by DNP-levan conjugates. | Tolerance induction of IgE antibody-forming cells by dinitrophenylated levan (DNP-LE) conjugates was investigated in CBA mice. Antibody production was measured by passive coutaneous anaphylaxis on rat skin. Specific antibody neutralization was obtained with conjugates of different substitution degrees. Specific inhibit... | 72,672 | [
0.1174156,
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0.005516439,
0.2676911,
0.2407242,
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0.2169668,
0.1265713,
0.2167448,
0.3159911,
0.2123272,
-0.060455,
-... |
Preparation and assessment of antisera to ACTH. | Antisera to ACTH were produced in rabbits injected repeatedly at multiple intradermal sites with synthetic [Asp25, Ala26, Gly27]alphah-corticotropin-(1-28)-octacosapeptide-bovine gamma globulin conjugate (octacosapeptide is a sequence analogue of alphah1-28-ACTH). Antibodies to extracted human or porcine ACTH were dete... | 72,698 | [
-0.1883297,
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0.1512579,
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0.1369263,
0.5756816,
0.4146068,
0.1512517,
-0.0600205,
... |
Myocardial infarct size: clinicopathologic agreement and discordance. | An accurate postmortem method of planimetrically estimating the extent of myocardial infarction was employed in 16 cases. Delineation of necrotic myocardium was enhanced by a macroscopic staining technique, which utilizes a tetrazolium dye. Comparison of infarct size with peak serum creatine phosphokinase levels showed... | 72,721 | [
-0.1413538,
0.2571733,
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0.07352095,
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0.02429349,
0.2375135,
0.3546745,
0.2683323,
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-0.2643573,
-0... |
The control of specificity of cytotoxic T lymphocytes by the major histocompatibility complex (AG-B) in rats and identification of a new alloantigen system showing no AG-B restriction. | The regulatory influence of the rat major histocompatibility complex (MHC) (Ag-B complex) on the specificity of cytotoxic T lymphocytes was investigated. It was shown that the effector cells were specific for the original Ag-B phenotype in rat systems in which the responder and stimulator cell populations were unquesti... | 72,782 | [
0.01279894,
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0.2070225,
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0.09549654,
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0.1925041,
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0.1001007,
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0.1412349,
0.2956892,
0.1582956,
0.3416452,
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0... |
Laboratory characteristics of poxviruses isolated from captive elephants in Germany. | Proxviruses isolated from captive elephants in Germany have been characterized. Although related to vaccinia and even more closely to cowpox virus, the separate identity of elephantpox virus was established by both biological and serological methods. Elephantpox virus produces A-type inclusions in infected cells, as di... | 72,786 | [
0.1520063,
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0.02165867,
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0.2113499,
0.3030545,
0.1029974,
0.4041549,
-0.301486,
... |
Recurrent Bell's palsy. Etiology, frequency, prognosis. | The etiology, frequency and prognosis of recurrent Bell's palsy were studied in patients with peripheral paresis of n.facialis of various etiology. Fourteen (11.9%) of 117 patients with Bell's palsy had a recurrent paresis of n.facialis. Nine of these were of homolateral and five contralateral type. Seven recurrent fac... | 72,801 | [
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0.07229991,
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0.03950357,
0.0001669257,
0.07377528,
0.2091039,
-0.08964968,
-0.3121333,... |
Cerebral coenurosis. Report of a case with arteritis. | A case of the unusual clinical condition of cerebral coenurosis, the unique parasitic disease that is localized only in the CNS, is reported. The patient had repeated attacks of transient hemiparesis due to intracranial arteritis which was demonstrated by several angiographic studies. The CSF showed a discreet lymphocy... | 72,809 | [
-0.2345593,
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0.1843754,
0.1932702,
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0.2643647,
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... |
Influence of temperature on neuromuscular transmission in myasthenia gravis. | The effect of local cooling was studied in 28 patients with myastenia gravis. We stimulated the ulnar nerve with single stimuli and trains at 3/s for 2s and at 50/s for 1.5 s. The compound muscle action potential (MAP), the muscle twitch and the isometric tetanic force of the adductor pollicis were registered. 1. At 3/... | 72,810 | [
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0.1128701,
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0.1140599,
0.3884147,
0.2982116,
0.0451205,
0.... |
The effect of hydrocortisone on the serum creatine kinase activity of muscles diseases. | Intravenous administration of a single dose of hydrocortisone to patients with the Duchenne type of progressive muscular dystrophy, carriers of Duchenne dystrophy gene caused a short-lasting rise of the serum creatine kinase activity. Administration of hydrocortisone also raised the serum CPK activity in some carriers ... | 72,811 | [
-0.1417658,
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0.1359314,
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0.180005,
0.007977695,
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0.08678684,
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0.3253156,
0.2500152,
0.06602222,
-0.003005783,
-0... |
A surface antigen associated with Hodgkin's disease: brief communication. | We used an indirect immunofluorescence technique to detect a surface antigen that may be associated with Hodgkin's disease (HD). A heteroantiserum raised in a rabbit given an injection of cells obtained from an HD lymph node (Stage I, classification of Lukes and Butler) allowed us to detect an antigen on the surfaces o... | 72,826 | [
0.06476654,
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0.1706795,
-0.1398851,
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0.3035402,
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0.2769427,
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0.1650741,
-0.09161981,
0.0507315,
0.1638045,
0.06004238,
... |
Treatment of female stress incontinence with midodrine: preliminary report. | For 10 days 21 female patients with clinical stages I to III stress incontinence and 4 continent control female patients were treated with the alpha-sympathomimetic midodrine. Urethrometry revealed that alpha-adrenergic stimulation resulted in an increase in the urethral occlusion pressure of up to 30 per cent and, cys... | 72,832 | [
-0.1966186,
0.2588431,
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0.004853431,
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0.08001124,
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-0.06826296,
0.1255097,
-0.2300178,
0.1357832,
0.312782,
0.1068024,
0.2706501... |
Association between exaggerated responsiveness to thyrotrophin-releasing hormone and hypercholesterolaemia. | Thyroid-function tests were performed on one hundred patients with suspected premyxoedema and the results compared with those in twenty age and sex matched controls. The increase in thyroid-stimulating hormone (T.S.H.) in response to thyrotrophin-releasing hormone (T.R.H.) was exaggerated in eighty-eight of the hundred... | 72,952 | [
-0.13549,
-0.4596788,
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0.09065633,
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0.0671675,
0.3923132,
0.1721197,
0.02974438,
-... |
Antibiotic-induced colitis implication of a toxin neutralised by Clostridium sordellii antitoxin. | A toxin(s) has been demonstrated in the stools of two patients with antibiotic-associated colitis. This toxin(s) was heat-labile, was rapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not ... | 73,011 | [
0.0354547,
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0.3088048,
0.3312233,
0.03686929,
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0.07259471,
0.353241,
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0.1750586,
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0.08949467,
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0.01163176,
0.1910973,
0.1412468,
0.2256294,
-0.01270257,
0.0... |
Clofibrate increases lipoprotein-lipase activity in adipose tissue of hypertriglyceridaemic patients. | Clearance of plasma-triglycerides and activity of lipoprotein lipase in adipose tissue were studied in six hypertriglyceridaemic patients before and after a week of clofibrate therapy (2 g/day). Plasma-triglycerides decreased significantly from 6.85 +/- 1.1 to 2.66 +/- 0.29 mmol/l and triglyceride clearance increased s... | 73,012 | [
0.1366826,
0.2165753,
-0.3841797,
0.09282365,
0.08697608,
0.01561535,
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0.1509814,
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0.439599,
-0.07695111,
0.2778189,
-0.1934622,
-... |
Ultraviolet-mediated antibiotic activity of species of Compositae caused by polyacetylenic compounds. | A survey of North, Central, and South American composites, and of certain polyacetylenic compounds occurring in them, confirmed that the ultraviolet-mediated antibiotic activity against Candida albicans can be ascribed to the presence of particular polyacetylenes and their thiophene derivatives. Leaves, stems, roots, a... | 73,121 | [
0.1641967,
0.2473449,
0.2423233,
0.1443349,
0.02954197,
0.04310576,
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0.5315704,
0.2425354,
0.1409021,
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0.03734012,
0.1954533,
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0.02915223,
0.3502494,
0.2517703,
0.7071607,
0.3110497,
-0.06643008,
0.1... |
Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid). | Poly (2-azaadenylic acid) [(aza2A)n] and poly(2-azainosinic acid [(aza2I)n], two newly synthesized analogues of (A)n and (I)n, in which CH-2 of the purine ring is replaced by a nitrogen atom, have been evaluated in various biological assay systems. (Aza2A) n formed a complex with (U)n and (br5U)n, and (aza2I)n formed a... | 73,166 | [
-0.2380638,
-0.04012755,
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-0.1315667,
0.6180198,
0.05034892,
0.008108236,
0.3024874,
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0.07309169,
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0.4284671,
0.5199434,
0.09194366,
-0.08145... |
Antigen-specific purification of blocking factors from sera of mice with chemically induced tumors. | Serum from mice with growing tumors can prevent ("block") the destruction of tumor cells by immune lymphocytes, as measured in a microcytotoxicity assay. Factors responsible for this blocking activity were purified by binding to immune adsorbents that had been prepared from antibodies obtained by immunizing BALB/c mice... | 73,182 | [
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-0.04024972,
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0.1157796,
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0.09194355,
0.5183774,
0.170969,
0.01977709,
-0.3285761,
... |
Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | We have developed a simple and rapid system for the denaturation of nucleic acids and their subsequent analysis by gel electrophoresis. RNA and DNA are denatured in 1 M glyoxal (ethanedial) and 50% (vol/vol) dimethyl sulfoxide, at 50 degrees. The glyoxalated nucleic acids are then subjected to electrophoresis through e... | 73,185 | [
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0.3637995,
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0.1268004,
0.2562012,
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0.3... |
Histochemistry of free and esterified cholesterol in human atherosclerotic arteries. | The described technique provides a sensitive, specific and accurate method for the nondestructive localization of cholesterol in tissues. The staining patterns observed closely correspond to those obtained with oil red O, but allow discrimination between sites where free and esterified cholesterol is present. | 73,194 | [
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0.3180585,
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0.007611287,
0.2711... |
Hepatitis B "e" antigen: an apparent association with lactate dehydrogenase isozyme-5. | Serums containing the "e" antigen of hepatitis B virus were subjected to electrophoresis in polyacrylamide gel. An extra band appeared in the lactate dehydrogenase isozyme pattern, but this band was undetectable in serums containing antibodies to the e antigenic determinant. Prior separation of the lactate dehydrogenas... | 73,221 | [
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A new endoprosthesis for nonoperative intubation of the biliary tract in malignant obstructive jaundice. | A method for palliative treatment of obstructive jaundice due to malignant growths consists of an indwelling tube, endoprosthesis, inserted percutaneously transhepatically under local anesthesia. A permanent bile drainage was established in 12 patients with inoperable obstructions of the bile duct, and in seven, a temp... | 73,227 | [
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[Evaluation of the results of treatment of Graves' disease by synthetic antithyroid drugs]. | A study of 43 case records of Grave's disease followed up for at least two years after stopping treatment with synthetic antithyroid drugs, revealed 7 patients who did not relapse, 12 cases of rebound, (less than six months after stopping treatment), and 21 cases of recurrence (more than six months) of 10 cases (23%) h... | 73,224 | [
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Improved staining boxes for fast, uniform staining of ultrathin sections on grids. | A standard LKB (LKB-Produkter Ab. S-161, 25 Brommma 1, Sweden) grid storage box is converted into several grid staining boxes by sawing the body of the box into segments along rows of its grid storage cavities. The staining boxes can be cut out to any required size or shape. The polymethyacrylate storage box cover is d... | 73,234 | [
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An unusual case of benign mucous membrane pemphigoid. | This case of benign mucous membrane pemphigoid (BMMP) is unusual in that blistering, scarring lesions were confined to the skin for 15 years before mucous membranes were involved. The onset of this disorder at the age of 38 is also unusual. Detailed immunological investigation was performed on this patient but the resu... | 73,315 | [
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Reticular erythematous mucinosis syndrome: report of a case. | A 47-year-old man with erythematous, maculopapular rash on the chest and the back. Histology showed perivascular infiltration of lymphocytes, especially around hair follicles, and alcian green positive deposits in the dermis. Some improvement was achieved by treatment with 200 mg oxychloroquine sulphate (Plaquenil, Win... | 73,318 | [
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Acid alpha-naphthyl acetate esterase staining of T lymphocytes in human skin. | T lymphocytes were stained in order to disclose alpha-naphthyl acetate esterase activity (ANAE staining) by adopting the method described by Mueller et al. In ANAE-staining of frozen sections from human lymph nodes, more than 90% of the lymphocytes in paracortical areas (T cell areas) were ANAE-positive, but in cortica... | 73,323 | [
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[Detection of a new lipoprotein: Lp(a). Its occurrence in atherosclerosis with or without hyperlipemia]. | Detected using a method involving gradient electrophoresis on polyacrylamide gel, the presence of a high level of an Lp(a) was demonstrated in 17% of control subjects and 39% oh hyperlipidaemic subjects explored. The difference appeared to be particularly significant in subjects with a pure hypercholesterolaemia (type ... | 73,359 | [
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Fiber types and metabolic potentials of skeletal muscles in sedentary man and endurance runners. | This description of some of the present knowledge on skeletal muscle fibers, their metabolic potentials, and their interplay with the degree of physical activity has revealed that skeletal muscle of man has a very large capacity for adaptation. Moreover, this adaptability appears to be of utmost importance for the meta... | 73,362 | [
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The potential advantages and requirements of live attenuated influenza virus vaccines. | Live attenuated influenza A virus vaccines are potentially the most efficient and effective method of immunization against epidemic influenza, and offer the only feasible means of mass vaccination at a socially acceptable cost. The advantage of live virus vaccines are described and compared with killed virus vaccines i... | 73,370 | [
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Heparin cofactor activity during and after extracorporeal circulation with bubble and membrane oxygenators. | Heparin cofactor activity as measured by an amidolytic method has been investigated in 48 patients undergoing cardiac surgery with extra-corporeal circulation (E.C.C.). Heparin cofactor activity is reduced soon after the start of E.C.C., due to hemodilution but it returns towards initial levels at the completion of the... | 73,390 | [
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Metastatic orchioblastoma: alpha1-fetoprotein in diagnosis and combination chemotherapy in treatment: a case report. | A case in which orchioblastoma metastasised to a lymph node at the left renal hilum is described. The metastasis was not detected by bipedal lymphography, but was associated with a rise in the serum level of the alpha1-fetoprotein. The metastasis responded to combination chemotherapy, including adriamycin, and residual... | 73,396 | [
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Serum dihydrotestosterone in patients with benign prostatic hypertrophy. | Serum dihydrotestosterone (DHT) and testosterone were measured by radioimmunoassay in 24 normal men aged 60 to 80 years and in 25 patients with benign prostatic hypertrophy in the same age range. There was a significant increase in the level of dihydrotestosterone in patients with prostatic hypertrophy but no significa... | 73,397 | [
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Serum alphafetoprotein in cystic fibrosis of the pancreas. | Serum alphafetoprotein concentrations were measured by three different types of radioimmunoassay in 30 patients with cystic fibrosis of the pancreas and in 55 controls. The highest value obtained in cystic patient was 10.2 ng/ml and in a control 10.8 ng/ml. These are within published normal limits. Previously reported ... | 73,432 | [
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Intra-vital staining as an aid to parotid gland surgery. | Successful parotid surgery depends on the careful identification and dissection of the facial nerve, and to prevent recurrence all tumours should be excised with a wide margin of normal tissue. These two requirements are facilitated by the technique of intra-vital staining of the parotid gland with 2.5% methylene blue ... | 73,435 | [
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Inhibition of antibody production in plasmacytoma cells by antigen. | Tissue culture-adapted MOPC 315 mouse plasmacytoma cells which secrete monoclonal anti-DNP IgA antibody, were cultured with a variety of DNP-carrier conjugates and the production of IgA measured by pulse labeling with [3H]leucine and by plaque-forming cell assays. DNP-coupled bovine, human and rabbit gamma-globulins (c... | 73,462 | [
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Cell-mediated immunity in vasectomized rhesus monkeys. | Cell-mediated immunity in rhesus monkeys that had been vasectomized for 2, 4, 7, or 11 years was measured by lymphocyte blastogenesis following stimulation with concanavalin A, phytohemagglutinin (PHA), and pokeweed mitogens. Several of the 7- and 11-year vasectomized animals had significantly reduced PHA reactivity wh... | 73,480 | [
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Immunohistochemistry of carcinoembryonic antigen: characterisation of cross-reactions with other glycoproteins. | In the course of demonstrating carcinoembryonic antigen (CEA) in normal human small intestine cross-reactivity of specific antiserum against red blood cells, vascular endothelium, and Paneth cell granules was noted. Pretreatment of sections with periodic acid eliminated these cross-reactions without affecting the stain... | 73,495 | [
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Antigens in penicillin allergy. I. A radioimmunoassay for detection of penicilloylated protein contaminants in penicillin preparations. | This communication presents a sensitive and discriminative method for detection of protein impurities in penicillin preparations. Antibodies against various penicilloyl derivatives of high avidities and specificities raised in rabbits were coupled to microcrystalline cellulose. The amount of penicilloyl antigen present... | 73,504 | [
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Stimulation of heme accumulation and erythroid colony formation in cultures of chick bone marrow cells by chicken plasma. | A fibrin clot culture system with high plating efficiency is described for the growth of erythroid cells from chick bone marrow. Erythroid colonies grown in the absence of adult chicken plasma (spontaneous colonies) were either benzidine-negative or weakly benzidine-positive. Colonies grown in the presence of chicken p... | 73,544 | [
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Clinical evaluation of commercial conjugates for direct immunofluorescence of herpes simplex virus. | Commercially prepared antibody conjugates that are now available allow extensive application of direct immunofluorescence for diagnosing herpetic infections. Five of these conjugates--Microbiological Associates bivalent herpes antiserum (MBA-bivalent), MBA anti-herpes types 1 (MBA-1) and 2 (MBA-2), and Flow Laboratorie... | 73,546 | [
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Human papovavirus in Papanicolaou smears of urinary sediment detected by transmission electron microscopy. | A technique is described whereby inclusion-bearing cells identified by light microscopy in stained smears of urinary sediment were reprocessed for examination in the electron microscope. The nuclei of the abnormal cells were found to contain numerous virus particles, 35 nm in diameter, which morphologically resembled p... | 73,550 | [
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Polymeric cryoprotectants in the preservation of biological ultrastructure. III. Morphological aspects. | Two high molecular weight polymers, polyvinylpyrrolidone (PVP) and hydroxyethyl starch (HES), have been used as cryoprotectants for preparing specimens to be freeze fractured. Solutions of 25% (w/w) suppress the formation of intracellular ice in single cells and tissue blocks from both plants and animals to the extent ... | 73,593 | [
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A course in emergency care for first-year medical students. | A 52-hour course in emergency medicine for first-year medical students was developed from the Department of Transportation's (DOT) training program for emergency medical technicians (EMT). The objective of the course was to train students to provide life support and emergency care in the field at the level of competenc... | 73,603 | [
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Reduced active thyroid hormone levels in acute illness. | In acute and subacute disease the active thyroid hormones, triiodothyronine (T3) and tetraiodothyroacetic acid (tetrac), are decreased while serum-thyroxine (T4) levels tend to be slightly reduced. Conversely, the inactive metabolite, reverse triiodothyronine (reverse T3), is increased indicating a diversion of T4 meta... | 73,636 | [
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0.1197334,
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A controlled study of therapeutic portacaval shunt in alcoholic cirrhosis. | A controlled study of therapeutic end-to-side portacaval shunt was carried out from 1968 to 1971 in 89 patients with alcoholic cirrhosis. Recurrent gastrointestinal bleeding was less common and chronic hepatic encephalopathy was more common in patients with shunts than in patients without shunts. The survival-rate was ... | 73,637 | [
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Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases. | It is suggested that the mechanism of muscle-cell necrosis in various muscle diseases is explained by an increased net influx of calcium into cells which triggers a "vicious cycle" of mitochondrial calcium overloading and energy depletion. If correct, this hypothesis may offer the basis of a more rational treatment of ... | 73,643 | [
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Changes of vasopressin in hypertension: Cause or effect? | Plasma concentrations of arginine-vasopressin (antidiuretic hormone) have been measured in 40 patients with benign essential hypertension and 12 patients with malignant-phase hypertension. Values tended to be low in the benign phase and high in the malignant phase. 5 normal subjects were infused with synthetic arginine... | 73,691 | [
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0.1121121,
0.2360744,
0.1659339,
0.2890837,
-0.2450178,
0.05531267,
-0.3720211,
-0.2743705,
-0.03632937,
0.1319133,
0.1908908,
-0.04761431,
0.2392279,
0.1782673,
-0.06696953,... |
A pseudohemipharetic form of Parkinson's disease. | Parkinson's disease can present as a progressive hemiparesis without tremor. The presence of mild cogwheel rigidity in a hemiparetic patient may suggest the diagnosis, as may the normal findings on brain scan and electroencephalogram in a patient with gradually evolving hemiparesis. The response to appropriate medicati... | 73,743 | [
-0.2106864,
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0.1461902,
0.05196827,
-0... |
Cimetidine in the treatment of active duodenal and prepyloric ulcers. | 44 patients with endoscopically confirmed duodenal (36) or prepyloric (8) ulcers have received in a double-blind trial either the histamine H2-receptor antagonist cimetidine (30 patients) or placebo (14 patients) for six weeks. At three weeks 67% of patients treated with cimetidine and 17% of those receiving placebo ha... | 73,792 | [
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0.07105304,
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0.1169406,
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Host resistance to lipopolysaccharides in the pathogenesis of multiple sclerosis and membranoproliferative glomerulonephritis. | Host resistance against bacterial lipopolysaccharides (L.P.S.) and especially against its toxic part lipid A has earlier been demonstrated in biological assays. In this paper an aryl-esterase is shown to be associated with alfa-1-lipoprotein (ArE) and is probably responsible for the detoxification of L.P.S. in man. Fur... | 73,807 | [
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0.1192439,
0.410547,
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0.3375594,
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0... |
Salivary phenytoin concentrations in epilepsy and in chronic renal failure. | Plasma total, plasma unbound (free, therapeutically active), and salivary phenytoin concentrations have been measured in seventeen epileptics and in seven patients with chronic renal failure on long-term phenytoin therapy. Patients with chronic renal failure had low plasma total, but disproportionately high plasma free... | 73,850 | [
0.02177421,
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0.1072537,
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0.05336824,
-0.1953296... |
An automated test for the detection of significant bacteriuria. | A fully automated technique for the rapid detection of significant bacteriuria is described. The method, which depends on the detection of bacterial adenosine triphosphate (A.T.P.) by bioluminescence, was found to have better sensitivity than a conventional cultural technique which uses a standardised loop. Results wer... | 73,857 | [
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0.1989555,
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0.567351,
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0.2... |
Bacterial overgrowth syndrome without "blind loop": A cause for malnutrition in the elderly. | Probable bacterial contamination of the small bowel without an anatomical sump occurred in 5 elderly patients (age 68--94). They presented with severe general deterioration in health rather than with obvious features of malabsorption. This syndrome has not been clearly described before. Bacterial deconjugation of bile ... | 73,899 | [
0.09022664,
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0.3760945,
0.2406696,
0.123648,
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0.2981508,
0.1942315,... |
Metabolic immunodepression which increases the risk of cancer. | When some metabolic changes occur--namely, when blood levels of free fatty acids (F.F.A.), insulin, cholesterol, or triglycerides rise--cellular immunity becomes depressed. These metabolic changes also promote the division of somatic, non-lymphoid cells, which in turn increases the possibility of malignant transformati... | 73,905 | [
-0.193362,
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0.3975115,
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0.2075051,
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-0.1238568,
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0.1909685,
0.4643624,
-0.2266651,
0.1655877,
-0.1637253,
... |
Effect of coronary bypass surgery on longevity in high and low risk patients. Report from the V.A. Cooperative Coronary Surgery Study. | There is considerable uncertainty about the effects of bypass surgery on the longevity of patients with coronary-artery disease and angina. The Cleveland Clinic has reported improved survival after surgical treatment; the Duke University study indicated improvement in a high-risk subgroup only. The Veterans Administrat... | 73,949 | [
-0.003642763,
0.05912428,
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0.1016744,
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0.423038,
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-0.2613653,
0.1276916,
0.4967081,
0.09037459,
0.3341239,
0.3107985,
-0.08634111,... |
Inhibition of phagocytosis in vitro by obligate anaerobes. | A variety of species of obligate anaerobes have been shown to interfere with the phagocytosis and killing of Proteus mirabilis and other aerobic bacteria in vitro. Although all the obligate anaerobes examined showed this activity, the effect was greatest with strains of Bacteroides melaninogenicus and B. fragilis. In c... | 73,952 | [
-0.223489,
0.2526586,
-0.06380762,
0.2674483,
-0.0793214,
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-0.2413108,
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0.2427105,
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-0.3165729,
-0.4301071,
-0.04258005,
0.1189358,
-0.1054064,
0.114757,
0.03085154,
0.1279676... |
Immune response in dog. 3. Antibody formation in dogs and rabbits to human serum proteins and keyhole limpet haemocyanin. | Antibody formation in dogs and rabbits to human serum proteins and keyhole limpet haemocyanin (KLH) following primary, secondary and multiple stimulation was analysed. Primary injection of human serum stimulates the formation of precipitin antibodies to beta2 lipoprotein in dogs, beta2 lipoprotein and beta globulin in ... | 74,005 | [
0.03687409,
-0.0607351,
-0.3302247,
-0.1577289,
0.09577841,
-0.1939331,
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0.1385488,
0.3040341,
0.1597105,
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0.01211142,
0.2069354,
0.1408449,
0.2957924,
0.1720024,
-0.07336243,
... |
[Palliative treatment of primary and metastatic tumors of the pancreas]. | In primary carcinomas of the pancreas the palliative intervention shows worse results than the radical operation according to our experiences. Deviation is only justified with local irresectable tumours as a symptomatic procedure. In cases of metastatic tumours in the pancreas palliative resection may be the only way i... | 74,057 | [
0.05633792,
0.00771237,
-0.1572279,
-0.1364588,
-0.09813524,
-0.3019048,
-0.06247346,
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0.08909876,
0.08153963,
0.2125971,
0.05141156,
-0.2104446,
-0.4160578,
-0.3278418,
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-0.2648571,
0.1619747,
0.3498251,
0.3012675,
0.2467751,
-0.09689825,
-0.1023646... |
Studies on the neutralization of rabbit antibodies to human factor VIII. | The capacity of normal and haemophilic cryoprecipitates to neutralize the anticoagulant effect of rabbit antibodies to human factor VIII (anti-VIII) was assessed using a quantitative estimation of antibody. About 4 times as much anti-VIII could be neutralized by normal factor VIII as was required to neutralize clotting... | 74,103 | [
-0.05272105,
0.3002359,
-0.2021252,
0.1480799,
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-0.1024582,
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0.114866,
0.2052402,
0.1783755,
0.02022206,
-0.1067027,
... |
Primary liver cell carcinoma (PLCC) in the Northern Guinea Savanna of Nigeria. | There is a high prevalence of primary liver cell carcinoma in the Guinea Savanna country of Nigeria, one of the highest frequencies in the world. The highest frequency of the tumour was among males aged 20 to 49 years. The clinical and laboratory findings are similar to those found in other series in Africa. Alpha1-foe... | 74,110 | [
0.07534459,
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-0.2715765,
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0.02882165,
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0.07225896,
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0.06931569,
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0.009739703,
0.3431526,
0.2264994,
0.2136021,
0.372071,
-0.3861971,
... |
[Further study of spontaneous virus production using transplantable HEp-2 cells as a model]. | Two maxima of optic density were observed at zones of gravity 1.27 g/ml and 1.15-1.16 g/ml by sedimentation equilibrium in sucrose gradient of cultural fluid, obtained from the transplantable cells of the HEP-2 strain and concentrated by ultracentrifugation. These fractions thus isolated were tested for presence of RNA... | 74,126 | [
-0.07411218,
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-0.1260092,
0.09046142,
0.2492667,
0.6010057,
-0.1157237,
-0.3984617,
0... |
Studies on carrier protein in contact dermatitis: macrophage migration inhibition by soluble epidermal substances as carrier proteins. | The migration of peritoneal exudate cells from picrylchloride-sensitive guinea pigs can be inhibited by the water-soluble proteins present in the picrylchloride-treated guinea pig epidermis. Further examination of these proteins revealed that antigens were present in fractions with the molecular weights ranging between... | 74,164 | [
0.0490903,
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0.2526071,
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0.03614809,
-0.05774643,
0.1440666,
-0.2094295,
0.1566281,
-0.04694407,... |
Lichen planus: an ultrastructural study. | Ultrastructural features of skin lesions are described in 11 patients with lichen planus. Keratinocytes and melanocytes in the basal layer show loss of nuclear membrane, disappearance of nucleoli, homogenization of nuclear material, and aggregation of tonofilaments around the nucleus to resemble cells in the late proph... | 74,169 | [
-0.1418392,
0.04964387,
0.1768247,
0.181146,
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0.1929886,
-0.0655576,
0.1935194,
0.349957,
-0.1115405,
-0.19396... |
A haemorrhagic bullous eruption of the hands caused by phenylbutazone: a report of 3 cases. | Three patients developed a haemorrhagic eruption on the hands after taking phenylbutazone. The reaction appeared within two weeks of taking the drug and is probably an allergic capillaritis. All patients showed generalised capillary fragility with a positive Hess test which became negative within a week of stopping the... | 74,176 | [
0.08852376,
0.07779291,
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0.007169394,
0.1777814,
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0.4526265,
-0.09918711,
0.1372345,
0.1213277,
0.1171296,
0.02807585,
... |
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