title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Microcalorimetry as a tool for evaluation of antibacterial effects of doxycycline and tetracycline. | The heat effects produced by a strain of Escherichia coli in the presence of doxycycline and tetracycline were determined by calorimetric measurements using batch and flow microcalorimeters of the heat-conduction type. There was a clear difference in the capacity of the two tetracyclines to suppress the metabolism of t... | 795,008 | [
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Doxycycline concentration levels in bone, soft tissue and serum after intravenous infusion of doxycycline. A clinical study. | As part of a longitudinal study, the influence of preoperative single dose doxycycline treatment on the overall incidence of early postoperative wound infections in orthopaedic surgery, 34 patients with various fractures were given an intravenous infusion of doxycycline 2-4 hours before the operation. The serum concent... | 795,010 | [
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Influence of pretransplant transfusions on kidney graft survival. | A study was made to elucidate the influence of transfusions on graft survival in 42 transplanted patients. In this series of multitransfused patients the number of units given was without significance, whereas transfusions given before onset of renal disease deteriorated graft prognosis. Possible explanations are discu... | 795,016 | [
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Country practice in the 1920's. | Experiences in a country practice in the Eastern Cape and later in small town practice during the 1920s are described. Economic circumstances compelled me to become a general practitioner. I had regrets in 1924, but nor since then. General practice has been a rewarding experience. | 795,053 | [
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A clinical and epidemiological study of gastro-enteritis. | Over a 13-year period, 2,903 Asian, Coloured and White children with gastro-enteritis were admitted to the Wilkins Infectious Diseases Hospital, Salisbury. During a pilot study of 250 patients conducted over the first 2 years, a definite seasonal variation in the occurrence of gastro-enteritis, with a peak incidence in... | 795,057 | [
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Precipitating antibody response to malarial S-antigens. | The gel diffusion test has been used to detect antibodies to malarial S-antigens. Sera were obtained from entire Gambian village communities, from young children with acute P. falciparum malaria, from children convalescent from such infections and from immune adults. In community studies, small selections of S-antigens... | 795,105 | [
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Pathology of liver transplantation. | Experience with renal transplantation indicates failure of the graft is usually due to immunological rejection. In a previous study of human liver transplantation, rejection was the major cause of transplant failure in 4 of 17 patients )24%); in this review of 76 liver transplantations, 64 of which survived the first p... | 795,113 | [
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A history of orthopedics in San Francisco and the West. | The unique development of early medical specialization in the West can be traced to California's geography and economic development. Such early specialization produced men with orthopedic inclinations. Early orthopedists founded the first medical school and the first modern teaching hospital, helped to found Stanford's... | 795,165 | [
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[The use of difluocortolone valerate in various dermatoses]. | Diflucortolone valerate was clinically investigated as a fatty ointment in 30 dermatological patients. Although this form of application is a special presentation for the treatment of very dry dermatoses, patients with not so dry and weeping dermatoses were also treated in this trial, the object being to include the ro... | 795,180 | [
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[Morphological changes using live vaccine from the suppressor S. typhimurium revertant in model experiments]. | The work of was aimed at the morphological study of the harmlessness and protective activity of the live salmonella vaccine prepared form the suppressor S. typhimurium revertant intended for the prophylaxis and treatment of carrier state after the sustained food poisoning. It was shown to model experiments on mice that... | 795,236 | [
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[Half a century since the discovery of tularemia in the USSR]. | The all-round and detailed study of tularemia carried out in the USSR for 50 years (1926-1976) offered a possibility to lay scientific foundation and to carry out an effective control of this infection in the whole country, providing a sharp and stable reduction of the incidence of this infection in man. By a number of... | 795,241 | [
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[Various data concerning the ultrastructure of Proteus spheroplasts]. | Spheroplasts were obtained under the action of penicillin on the same medium which was later used to obtain the L-forms. Spheroplast formation started 15 to 20 minutes after the addition of penicillin and reached the maximum in 2 hours. The first dividing forms were revealed at that time, and this division continued fo... | 795,247 | [
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[Properties of O-antigens of enterobacteria and construction of preparations for serological diagnosis of enteric infections by passive hemagglutination]. | Quantitative assessment of the main properties of the O-antigens of enterobacteria of significance in the reactions based on passive hemagglutination revealed the character of inter-relations between the antibody-binding, hemosensitive and specific agglutinating activity in various O-antigen preparations, and to lay fo... | 795,249 | [
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[Action of different cell types in influenza antibody production. 5. Keeping the immunologic memory to influenza virus A serotype by B- and T-lymphocytes]. | The authors present data on the cooperation of the B- and T-lymphocytes in secondary immunological response to the antigens of influenza virus of serological type A. Cells of the spleen, bone marrow and the thymus in various combinations from the intact and immunized animals were transplanted to sublethally irradiated ... | 795,250 | [
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The prevention of hyaline membrane disease: new concepts and approaches to therapy. | New approaches to hyaline membrane disease have emerged in recent years. These developments are principally attributable to advances in our understanding of the following: (1) the pathophysiology and pathogenesis of HMD in relationship to pulmonary surfactant, (2) fundamental aspects of fetal lung development, includin... | 795,280 | [
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Acrocentric chromosome associations in man. | Heterogeneity among chromosomes was found to be a highly significant source of variation for association proportions, while culture, slide, and observer were negligible sources of variation for association proportions although important for numbers of associations. The consequences of these results for tests of group d... | 795,295 | [
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Dapsone chemotherapy of Mycobacterium leprae infection of the neonatally thymectomized Lewis rat. | In order to learn whether the neonatally thymectomized Lewis rat (NTLR) infected with Mycobacterium leprae could serve as a model for chemotherapeutic studies in a situation resembling that found in human lepromatous leprosy, NTLR inoculated with M. leprae either locally or intravenously 9 to 16 months earlier were tre... | 795,312 | [
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[Non-Hodgkin hematosarcomas. Classification of the Reference Center of the World Health Organization (WHO)]. | At the request of the Leukaemia and Haematosarcoma Reference Centre of the World Health Organisation (W.H.O.), one of the authors (G.M.) has suggested a classification taking into account the most recent knowledge and all parameters (histological, cytological and immunological) necessary for the categorisation of non-H... | 795,324 | [
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Naproxen in rheumatoid arthritis. Extended trial. | 121 patients with active rheumatoid arthritis, 91 of whom had proved intolerant of other nonsteroidal anti-inflammatory agents, were treated for a mean of 10 months with naproxen. A dosage of 250 mg twice daily produced sustained improvement in most of the standard clinical measurements. 28 patients complained of side ... | 795,386 | [
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Kinetics of ribosome dissociation and subunit association studied in a light-scattering stopped-flow apparatus. | The association-dissociation kinetics of ribosomes from Escherichia coli have been studied under various conditions in a light-scattering stopped-flow apparatus. The dissociation reaction at 2 mg/ml at 25 degrees C, induced by lowering the MgCl2 concentration from 18 to 3 mM, can best be described by three independent ... | 795,460 | [
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Endotoxaemia and renal failure in cirrhosis and obstructive jaundice. | An investigation into the possible role of endotoxins in the pathogenesis of renal failure in cirrhosis and obstructive jaundice showed the two to be closely related. None of the patients with cirrhosis who had endotoxaemia had other evidence of Gram-negative infection at the time of the study, and the endotoxaemia was... | 795,499 | [
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A miniaturized counting technique for anaerobic bacteria. | A miniaturized counting technique gave results as good as the pour-plate and Most Probable Number (MPN) techniques for enumeration of clostridia spp. and anaerobic isolates from the gut. Highest counts were obtained when ascorbic acid (1%) and dithiothreitol (0.015%) were added to the reinforced clostridial medium used... | 795,533 | [
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Porfiromycin in the management of epidermoid and transitional cell cancer: a phase II study. | Porifiromycin has been tested in many groups of patients over the past several years (1-7). This report is an analysis of greater than 100 patients with epidermoid and urinary tract transitional cell carcinomas treated with this agent. A review of these data and the available literature on this agent shows that porfiro... | 795,539 | [
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Leucocyte aggregation and lymphocyte transformation induced by mercuric chloride. | Leuco-aggregation tests carried out on normal subjects using the non-specific mitogen mercuric chloride produced micro-aggregates in the concentration range 2-100 mug/ml with a peaking effect at about 10 mug/ml. These results showed good correlation with lymphocyte transformation test thymidine uptake ratios which were... | 795,578 | [
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Sequence studies on D-serine dehydratase of Escherichia coli. Primary structure of the tryptic phosphopyridoxyl peptide and of the N-terminus. | An improved procedure for large-scale production of crystalline D-serine dehydratase (EC 4.2.1.14) from Escherichia coli is described. The N-terminal sequence of the enzyme (Mr 45500) was determined in a solid-phase sequencer as Met-Glu-Asn-Ala-Lys-Met-Asn-Ser-Leu-Ile-Ala-Gln-Tyr-Pro-Leu-Val-Lys-Asp-Leu-Val-Ala-LEU-Lys... | 795,658 | [
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Enzyme-linked sandwich immunoassay of macromolecular antigens using the rabbit antibody-coupled glass rod as a solid phase. | A highly sensitive sandwich immunoassay of macromolecular antigens using the rabbit antibody Fab' - beta-D-galactosidase complex and the rabbit antibody immunoglobulin-G-coupled glass rod as a solid phase is described. The Fab' fragments of rabbit antibody IgG are conjugated with beta-D-galactosidase from Escherichia c... | 795,669 | [
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Studies on the mechanism of transduction by bacteriophage phi gamma. I. Genetic characterization of the transducing segment. | The bacteriophage phi gamma, though related to the lambdoid phage phi80, has unusual features in its specialized transduction and is being investigated to determine the mechanism of the transduction process. Genetic analysis of the transducing element gives evidence for a relatively long and uniform linear segment, up ... | 795,713 | [
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[Mutator effect of suppressed amber-alleles of early genes of bacteriophage T4]. | The mutator effect of amber alleles of three early genes (43, 32, 47), which were suppressed by the bacterial suppressor gene, was studied. There are some advantages in using the suppressed amber alleles instead of ts, because in this case definite amino acid substitutions take place in the protein due to certain suppr... | 795,721 | [
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In vitro colony growth of acute myelogenous leukemia. | Colony formation in vitro by marrow cells from patients with untreated acute myelogenous leukemia (AML) and from patients in AML relapse is infrequent using the standard Robinson assay. A newly developed culture system has been described in which marrow from AML patients in these disease stages form leukemic cell colon... | 795,747 | [
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[New therapeutic methods in gastroenterology]. | Operative-therapeutic endoscopy offers new aspects concerning polypectomy, electro- and laser-coagulation of hemorrhages, papillotomy and sclerosing of oesophageal varices. Active and passive immunization in hepatitis A and B will soon become available for clinical trial. The successful synthesis of human gastrointesti... | 795,763 | [
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Coccidia of the pheasant. | The author reviews the literature on the coccidia of the pheasant. Ten species are described, of which three are associated with disease in the United Kingdom, Eimeria colchici, E. duodenalis and E. phasiani. | 795,759 | [
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Biopharmacology of syphilotherapy. | Data collected from experimental rabbit syphilis and from in vitro studies with nonpathogenic treponemes can be extended only with great caution to human syphilis. The following tentative conclusions may be drawn: penicillin acts on Treponema pallidum by interfering with cell wall synthesis. Concentrations of penicilli... | 795,799 | [
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Immunohistochemical identification of T- and B-lymphocytes delineated by the unlabeled antibody enzyme method. I. Anatomical distribution of theta-positive and Ig-positive cells in lymphoid organs of mice. | The unlabeled antibody enzyme method was used to delineate the anatomical distribution of lymphocytes positive with a MBtheta and a-MIg in tissue sections of thymus, spleen, lymph nodes and Peyer's patches of mice. The known T- and B-cell areas were established. Moreover, individual B-cells are detected in T-cell regio... | 796,387 | [
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Chemotherapy--one of the causes of transient loss of HLA antigens and lymphocyte polyreactivity in patients with blood diseases and malignancies. | Modifications of HLA antigens (transient loss or polyreactivity) were found in thirty-two of fifty-five examined patients with blood diseases (leukaemia, reticulosis, reticulo- and lymphosarcoma, lymphogranuloma, erythroblastoma) and malignant tumours. In two cases of acute myelosis transient alteration of HLA-A 2 anti... | 796,392 | [
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Effect of galactose and sugar substitutes on blood insulin levels in normal and obese individuals. | Eighteen male patients between the ages of 25 and 50 were given on a double blind randomized basis (A) 40 gms. galactose (B) 50 gms. arabinogalactan and 0.11 gm. sodium saccharin (C) 2 gm. methyl cellulose and 0.083 gm. sodium saccharin and (D) 4 gm. galactose, all in 200 ml water. Blood glucose, galactose and insulin ... | 796,401 | [
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Stereological method for estimating relative membrane surface area in freeze-fracture preparations of subcellular fractions. | Microsomal fractions from liver cells are a mixture of vesicles derived from a number of different cellular membranes. These can be differentiated on freeze-fracture preparations by their characteristic density of intramembranous particles. A stereological method is developed which allows the estimation of the relative... | 796,456 | [
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[Clinical results of esophagojejunoplication (author's transl)]. | Indications, surgical technique, and clinical results in esophagojejunoplication are shown. In 46 patients the indication for total gastrectomy in 20 cases was a benign disease and in 26 cases cancer of the stomach. An essential feature of this method is the construction of a jejunal cuff, which is drawn around the ana... | 796,600 | [
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[Viability of Escherichia coli cultures]. | In the logarithmic phase of batch cultures of E. coli B and MRE-600, a high percentage (upto 80%) of the cells did not grow. Viability of the cells was estimated by inoculation on plates, in agar drops, and on slides. As was established by mathematical planning experiments, the viability and growth rate of the culture ... | 796,631 | [
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Mutagenic evaluation of ronidazole. | Ronidazole was evaluated for mutagenic potential using in vitro microbial tests and in vivo studies in mice. The microbial test used the histidine requiring mutants of Salmonella typhimurium with and without a rat liver microsomal activation system (Ames test). The studies in mice included the dominant lethal test, mic... | 796,694 | [
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The utilization of in vitro mutagenesis techniques to explain strain, age and sex related differences in dimethylnitrosamine tumor susceptibilities in mice. | The carcinogen dimethylnitrosamine (DMNA) is known to exhibit a high degree of strain, organ, age, and sex related tumor specificity in mice. Using microbial mutagenesis assay coupled with mouse tissue microsomal enzyme activation systems, evidence has been obtained that demonstrated a close relationship between the le... | 796,707 | [
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Metabolic studies and the evaluation of genetic risk from the viewpoint of industrial toxicology. | In recent years some important industrial chemicals, e.g. solvents, and monomers used in the production of plastics, have been found to be more dangerous than had been suspected. Some of them are mutagens and carcinogens. The active substance may be the compound itself, but more frequently it is a reactive intermediate... | 796,709 | [
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Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation. | Sister chromatid exchanges (SCE's) which are easily seen by "harlequin chromosome" techniques can be readily induced in cultured Chinese hamster ovary (CHO) cells by low concentrations of mutagen-carcinogens that do not require metabolic activation. If the cells are simultaneously treated with cyclophosphamide which do... | 796,721 | [
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Response to parenteral iron with and without androgen therapy in patients undergoing regular haemodialysis. | The effects of intravenous iron, with and without androgens, was studied in a group of 39 patients treated by regular haemodialysis, almost all of whom had normal serum iron concentrations. Intravenous iron 1-2 g every 4 months produced a significant rise in haemoglobin from 6.3 to 7.9 g/dl in 17 female patients with t... | 796,740 | [
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The spread of blood-borne metastases in malignant lymphomas of man. | An autopsy study was performed on 190 cases with Hodgkin's disease and on 134 cases with reticulum cell sarcomas. It was found that a cascade spread of metastases, as opposed to a random spread, was detectable in patients with Hodgkin's disease, but not in patients with reticulum cell sarcoma. Metastatic key-sites for ... | 796,773 | [
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[Practical interest of a micromethod for neuraminidase treatment of lymphocytes in transplantation immunology (author's transl)]. | Vibrio cholerae neuraminidase treatment increases the cell sensitivity to complement and antibodies cytotoxic action. This property can be applied to the microlymphocytotoxicity technic for antibodies study in dialysed and kidney transplanted patients and for pretransplantation cross-matches. The enzymatic treatment us... | 796,790 | [
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[Antibody coated bacteria in urinary sediment (author's transl)]. | The presence of antibody coated bacteria in the urinary sediment was correlated with the infection site in 151 patients. 86 patients were followed regularly and support sequential data. A positive test is noted in most of the chronic pyelonephritis cases in all the prostatitis cases and in some of the chronic infection... | 796,792 | [
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[Bone marrow's histopathology in tuberculosis of the hematopoietic organs (author's transl)]. | Through the reports of the literature, the histopathologic lesions of the bone marrow in tuberculosis of the hematopoietic organs are analysed. Whether the lesions are typical or not, it is necessary to have a bacteriologic proof of tuberculosis. Near these lesions, bone marrow's cellularity is often greater or lower, ... | 796,793 | [
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[Effect of phosphate upon calcium intestinal absorption (author's transl)]. | Adult rats receive 5 to 50 mM CaCl2 solutions in which glycerophosphate or sodium diacid phosphate may be added in variable quantity. These solutions are administered by gavage or in situ ligatured jejunal loop. The inhibition of calcium absorption dependent on simultaneously administered phosphate doses is well charac... | 796,796 | [
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Resection of malignant bone tumors. | Amputation is an unsatisfactory and depressing measure for the patient as well as for the surgeon. As long as operative removal of tumors in the extermities is indicated, the search for alternative solutions should be the most urgent task for every doctor involved in surgery. Resection would be the most equitable measu... | 796,920 | [
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Biochemical markers in cancer of the breast. | Currently, one could summarize this area by saying that we appear to be in a situation where three relatively nonspecific tests detect the majority of patients with metastatic disease, as well as those post-operative patients who are at high risk of relapse. The critical test of their utility for segregating those at r... | 796,922 | [
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Clinical evaluation of keto profen (Orudis) in rheumatoid arthritis: results of a multi-centre double-blind trial against phenylbutazone. | In a double-blind cross-over trial in rheumatoid arthritis, no difference was found between ketoprofen and phenylbutazone with regard to clinical efficacy at the dosages used. There was a higher incidence of side-effects reported during treatment with phenylbutazone. | 796,940 | [
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Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis: a double-blind cross-over comparison with indomethacin. | In a double-blind cross-over trial, ketoprofen was found to be as effective as indomethacin in the treatment of rheumatoid arthritis. Side-effects, particularly headache and vertigo, were less common in patients receiving ketoprofen. | 796,942 | [
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A clinical study of ketoprofen suppositories. | Ketoprofen administered via the rectal route seemed to be valuable when given at night to patients with various rheumatic syndromes and may be particularly useful for patients who show gastric intolerance of the capsules. Anal intolerance was noted in 12% of the patients. | 796,946 | [
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[Experiences with the CM snap attachment]. | An experience report is given on 250 CM Snap attachments. The retention of these precision attachments is due to the coil spring and cylinder. This system has proven to be exceedingly lasting. The range of indication is wide because of the many types available. The smaller types may even be used in cuspid teeth, since ... | 796,979 | [
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[Hygiene at the treatment area in the dental office]. | The state of hygiene in a dental office in the canton of Bern was examined. 22 bacteriological tests were made on the surfaces around the treatment area. Also, the water from the sprays and the most important instruments were tested. Before cleaning and disinfection the test objects showed an average of 110 microorgani... | 796,980 | [
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T and B lymphocytes in sarcoidosis: a clinical correlation. | Immunological abnormalities in sarcoidosis have been previously described. Cutaneous anergy to a wide variety of antigens first prompted the suggestion that the underlying defect may be of importance in the aetiology or pathogenesis of the disorder. The thymus derived lymphocytes appear to be particularly affected, and... | 797,043 | [
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Response of proliferative diabetic retinopathy to xenon-arc photocoagulation. A multicentre randomized controlled trial. Second interim report. | Patients with proliferative diabetic retinopathy had one eye chosen by a randomization procedure to have treatment by xenon-arc photocoagulation. 100 patients were followed for at least 1 year, 58 patients for 2 years, and 23 for 3 years. The patients form roughly two equal subgroups: those with new vessels on both opt... | 797,067 | [
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A study of two twice-weekly and once-weekly continuation regimen of tuberculosis chemotherapy, including a comparison of two durations of treatment. 1. First report: the results at 18 months. | The controlled clinical trial reported here was undertaken in Central Bohemia, West Slovakia and Prague. Patients in whom pulmonary tuberculosis had been newly diagnosed and confirmed bacteriologically were given standard triple chemotherapy with streptomycin, PAS and isoniazid for 6 weeks or 3 months. Continuation che... | 797,075 | [
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[Hazards in the operative treatment of Ductus Botallo (author's transl)]. | Possible errors and risks in operations of the ductus Botallo are discussed by using the experience from 282 operations. In young patients and adults the operative closure has to be decided upon according to the degree of the pulmonary vascular resistance. In newborns the closure of the ductus should be performed when ... | 797,176 | [
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[Experimental study of the stability of avirulent properties and the immunogenicity of suppressor revertants of streptomycin-dependent salmonella mutants]. | The authors aimed at the experimental confirmation of avirulent properties of suppressor revertants of streptomycin-dependent salmonella mutants and also at the study of their immunogenicity. Stability of the loss of virulence by the suppressor revertants was established by studying the virulence of the subcultures iso... | 797,191 | [
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In vitro-metabolism of 3H-progesterone in human testicular tissue: I Adult males. | Androgen biosynthesis in the male gonads may be analysed in some detail by means of in vitro incubation of minor testicular biopsy specimens with various radiolabelled steroid precursors. We have investigated nine adult human male voluteers without apparent gonadal dysfunction with regard to their in vitro metabolism o... | 797,210 | [
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Turku sugar studies X. Occurrence of polysaccharide-forming streptococci and ability of the mixed plaque microbiota to ferment various carbohydrates. | Dental plaque samples collected from the subjects during the last 20 months of the 2 year trial were subjected to quantitative and qualitative analysis of the occurrence of S. mutans, S. sanguis, S. salivarius and the total growth on phenol red agar. Lyophilized plaque samples were homogenized and incubated on a sucros... | 797,222 | [
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The alpha-helix as an electric macro-dipole. | A polypeptide chain is found to form an electric macro-dipole in solution when it is folded to take the alpha-helical conformation. This is due to the polar peptide residues, all of which are oriented to have their moment in the axial direction in its regular helical conformation. This remarkable electric nature of the... | 797,240 | [
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Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes. | An attempt has been made to provide a description of the mammalian alpha-keto acid dehydrogenase multienzyme complexes, especially with respect to the structure, assembly and function of PDC and OGDC based on the investigation carried out in this laboratory over the last 14 years. Special efforts have been focused on t... | 797,242 | [
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Clinical use of the LH-RH in assessing gonadotropic reserve in children with idiopathic precocious puberty, premature thelarche and premature adrenarche. | Serum LH and FSH were assayed in 31 girls with normal pre puberty, precocious puberty, premature thelarche, and premature adrenarche, aged 2 to 9 years. The effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on serum gonadotropins was evaluated in eleven of them. In all girls with precocious puberty, ser... | 797,330 | [
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[Intracellular organisation of bacteriophage tail-like bacteriocins of group A in Serratia marcescens (author's transl)]. | The biosynthesis of a phage tail-like Bacteriocin by cells of the group A-bacteriocinogenic (bA+) Serratia marcescens strain no. 16 after induction with mitomycin C (MC) was examined electron-microscopically. This bacteriocin (total length 117 nm) consists of a hollow core and a contractile sheath. At 60 min following ... | 797,334 | [
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Denture sore mouth. Aetiological aspects and treatment. | Seventy-four patients wearing full upper and lower dentures were examined in the study; 37 exhibited varying degrees of denture sore mouth (DSM) while the remaining 37 patients acted as controls. Denture trauma was more common in the DSM group. Candida was grown from 73 per cent of patients with DSM but only from 22 pe... | 797,370 | [
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Local and systemic effects in the non-specific tumour resistance induced by attenuated Salmonella enteritidis 11RX in mice. | Suppression of growth of a number of different murine tumours, injected subcutaneously or into the foot pad, was induced by prior intraperitoneal or intravenous immunisation with Salmonella enteritidis 11RX. The effect of immunisation on tumour growth was relatively minor, but could be enhanced by addition of 11RX anti... | 797,377 | [
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Drug protein binding and the nephrotic syndrome. | A reduction in plasma albumin concentration, as seen in patients with the nephrotic syndrome, is usually associated with a decrease in plasma protein binding of highly bound drugs. Therefore, the fraction of the unbound drug increases, but the absolute free concentration remains essentially unchanged due to a compensat... | 797,490 | [
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Propranolol disposition in chronic liver disease: a physiological approach. | The pharmacokinetics of propranolol can be quantitatively explained on a physiological basis from a knowledge of the effects of four biological determinants: (1) the activity of the drug metabolising enzymes (intrinsic clearance); (2) hepatic blood flow; (3) drug binding, and (4) the anatomical arrangement of the hepat... | 797,499 | [
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Clinical pharmacokinetics of levodopa in parkinson's disease. | Although levodopa has provided a major advance in the treatment of parkinsonism, its maximum benefits have not yet been realised, in part because of its complicated pharmacokinetics. This review summarises that available pharmacokinetic data involving levodopa, especially as it relates to therapeutic response of parkin... | 797,502 | [
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Deposition and clearance of inhaled particles. | Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans and animals, as determined principally by particle size, density, respiratory rate and flow parameters. Various models of inhaled particle deposition make use of convenient appro... | 797,567 | [
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A double-blind study comparing Daktacort, miconazole and hydrocortisone in inflammatory skin infections. | In a 4-week double-blind trial, Daktacort cream was compared with each of its constituents (i.e. miconazole 2% and hydrocortisone 1%) in a total of 63 patients (aged 12-60 years) with inflamed skin infections of bacterial or mycotic origin. Daktacort treatment induced a significant improvement of all symptoms within 1 ... | 797,593 | [
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Basic physiotherapy of spina bifida. | Physiotherapy for children with spina bifida uses very basic techniques which include prophylactic and therapeutic 'stretching', training to walk, supervision of calipers, and instruction to the parents. Success or failure of treatment very largely depends on the ability of the physiotherapist to teach and encourage th... | 797,604 | [
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Heterotopic dorsal-root ganglion cells around the spinal cord in children with spina bifida aperta. | Sixty-three of 95 cords from children with spina bifida aperta had associated heterotopic ganglion cells, usually located in dorsal nerve roots posterior or lateral to the cord. Heterotopic cells were more common in cords with complete or partial diplomyelia, and the largest number was found in the upper sacral region.... | 797,611 | [
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Types of neurogenic bladder in children with spina bifida, and response to treatment with phenoxybenzamine. | Seventeen children with spina bifida and neurogenic bladder were treated with phenoxybenzamine, an alpha-blocking agent, and in 15 cases the treatment was successful. It is suggested that in certain types of neurogenic bladder the need for urinary diversion can be avoided by treatment with phenoxybenzamine; only if thi... | 797,618 | [
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Improved compatibility of ALG therapy by application of aggregate free globulin. | Horse anti-human lymphocyte globulin (ALG) solutions contain, like human gamma-globulin preparations, a varying amount of IgG aggregates, which increase during longer periods of storage. Aggregate formation does not impair the immunosuppressive potency of ALG, as has been shown by prolongation of skin allograft surviva... | 797,668 | [
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An immunological investigation of a family with chronic mucocutaneous candidiasis. | Chronic mucocutaneous candidiasis in two siblings of consanguineous parents suggested an autosomal recessive transmission of the disease. We evaluated the two affected persons and 21 members of their kindred for an inherited immunological defect. Six members of the kindred, including both patients, had negative skin-de... | 797,672 | [
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A study of nerve regeneration and neuroma formation after nerve suture by various techniques. | The effectiveness of epineurial, perineurial, and a combined epiperineurial methods of nerve suture in the severed sciatic nerve of rabbits was studied by biochemical assay of the collagen just distal to the neuroma and the collagen and myelin of the posterior tibial nerve. Repairs were done both immediately after seve... | 797,699 | [
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Homosexuals and the death penalty in colonial America. | This article traces the legislative history of statues prescribing the death penalty for sodomy in 17th-century New England and in the other American colonies. New England and some middle colonies broke with English legal tradition by adopting explicitly biblical language. After the Revolution, Pennsylvania took the le... | 798,008 | [
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Improved resolution in cathodoluminescent microscopy of biological material. | This paper continues work reported in an earlier paper on modification of a Cambridge Stereoscan Mk IIA to improve the quality of cathodoluminescent micrographs of biological material. In the work presently described the microscope gun has been offset laterally by 2 mm, to prevent light from the filament passing down t... | 798,027 | [
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Simple magnetic holders for critical point drying of microspecimen suspensions. | Microspecimens can be critical point dried from suspension in holders consisting of three magnets and two filters. These holders are inexpensive, require no construction, and are easily assembled and disassembled. | 798,028 | [
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Elantrine in the treatment of parkinsonism. | A new drug, elantrine, blocks the tremorogenic effect of exotremorine, nicotine and harmine in animals. A double blind study compared elantrine with trinhexyphenidyl and against a baseline placebo period, in a group of Parkinson patients. Both, elantrine and trihexyphenidyl treatment, reduced tremor scores at the concl... | 798,127 | [
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Infections of the urinary tract during pregnancy: use of fluorescent antibody technic as an aid in patient evaluation. | Over a 22-month period, the fluorescent antibody (FA) technic was used to evaluate 195 patients with urinary tract infections (UTI) during pregnancy. Postpartum intravenous pyelograms (IVP) were obtained for 86 patients. The results were correlated as to the site (upper or lower urinary tract) of infection. Regardless ... | 798,291 | [
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0.2464539,
0.5386286,
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-0.2510445,
-0.5366169,
-0.6927306,
0.3727968,
-0.2374277,
-0.2054692,
0.119201,
0.2499616,
-0.249859,
... |
Contribution to the neurohaemal organs in pterygote insects. | In this review a comprehensive account of anatomy and various cell types occurring in the neurohaemal organs in Pterygote insects has been given. The chemical nature and composition of neurohaemal secretions and the mechanisms of liberation of neurosecretory material (NSM) from neurohaemal organs (NHO) have been descri... | 798,435 | [
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0.09511407,
0.2788023,
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0.114274,
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The lipid metabolism of the arterial wall and its abnormalities in diabetes. | Arteries are not simply conduits for the transport of blood, but consist of metabolically active tissue which has the capacity to synthesize all the components of the atherosclerotic lesion. The smooth muscle cell appears to be the most important metabolically active cell in the arterial wall. There is little informati... | 798,461 | [
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0.1684961,
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0.3365216,
0.02918091,
0.1326246,
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Renal prostaglandins and the regulation of blood pressure and sodium and water homeostasis. | In addition to its well known prohypertensive role in various states of experimental and human hypertension, the kidney has also been shown to exert an antihypertensive "endocrine" function. According to this hypothesis, certain forms of experimental and human hypertension might not solely be the result of an excess in... | 798,489 | [
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0.1034189,
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... |
[Interprétation of the gonadtropin response after LHRH in adult (author's transl)]. | The response to LHRH is never characteristic of a given hypothalamo-hypophysial gonadal axis except in the cases of severe gonadal disturbances, but reflects the functional states which can be observed under various circumstances. The same functional state may be found in different diseases and in contrast one disease ... | 798,537 | [
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0.04033868,
0.1828226,
0.3697991,
0.05659715,
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0... |
[Preliminary results of a cooperative clinical study of the new antitumor antibiotic, carminomycin]. | The clinical trials of karminomycin, a new Soviet antitumor antibiotic in treatment of different malignant tumors showed that the drug had a pronounced antitumor activity against the soft tissue sarcomas of various histogenesis, lympho- and reticulosarcoma, acute leukemia and some other neoplasms. | 798,543 | [
-0.03267321,
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0.03888813,
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0.3394582,
0.4350663,
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[Experimental study of the effect of a number of chemotherapeutic preparations on the intracellular growth of dysentery bacteria, and their interaction with epithelial cells]. | The effect of some chemotherapeutics on intercellular growth of Sh. sonnei and their capacity for penetration into cells Hep-2 and primarily triptinized cells of the monkey kidneys was studied. By the character of their effect the drugs were divided into 3 groups. The drugs of the first group, i.e. furazolidone had no ... | 798,546 | [
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0.0888185,
0.2578343,
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0.1284491,
0.49049,
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... |
[In vitro culture of human tumours and individual antineoplastic drug sensivity (author's transl)]. | The paper summarizes preparations of cell suspensions (mechanical, fermentative, by chemical agents) and from explant cultures. Several techniques of cell and tissue culture and determination of cell damage are described. The use of these techniques and the evaluation for individual testing of antineoplastic drug sensi... | 798,560 | [
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0.07182898,
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0.2231559,
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0.6264479,
0.4416668,
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0... |
[Antibacterial activity of the derivatives of dehydro-and deoxy-colic acids (author's transl)]. | The synthesis of derivatives of dehydro-and deoxy-colic acids with L-lysine and Lysil-lysine with antibacterial activity, is here described. Results show no antibacterial activity of dehydrocolic acid derivatives, while deoxycol-lys-OH-HCl, and particularly deoxycol-lys-NH2-2HCl, seem to be very effective on Gram-posit... | 798,554 | [
0.1349729,
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0.302541,
0.14145,
0.3284803,
0.5751302,
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0.009318456,
0.... |
Leukocyte inhibiting factor (LIF) production from human lymphocytes stimulated by bacterial lipopolysaccharides. | Leukocyte inhibiting factor (LIF) release from lymphocytes cultures stimulated by bacterial lipopolysaccharides (LPS) has been investigated. Human lymphocytes cultured in the presence of E, coli or S. enteritidis LPS were able to release in the supernatants a substance with the following properties: a) same elution pat... | 798,596 | [
0.008418944,
0.06480844,
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0.2632335,
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0.3761573,
0.1586343,
0.08085217,
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Is the antioxidant butylated hydroxytoluene a depigmenting agent in man? | Because of the allegation that butylated hydroxytoluene produced depigmentation in man, a prospective study was performed. Sixteen adult darkly pigmented males received daily occlusive applications for 60 days. Depigmentation was not observed. | 798,654 | [
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0.2890909,
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0.05260991,
0.1790345,
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... |
Columnar cells of the parietal layer of Bowman's capsule and their relationship with the sexual cycle in normal female mice. | The tubule-like cells (TLC) are present also in the parietal layer of the Bowman's capsule of the renal corpuscles in normal female mice kidney. These cells are morphologically similar to the cells of the proximal convoluted tubule. Further, significant variations of the TLC were present according to the phase of the s... | 798,696 | [
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0.04313124,
0.01988644,
0.09715188,
0.4634319,
0.06690207,
-0.08662... |
[Evaluation and comparison of five antianginal treatments by means of a bicycle ergometer exercise test (author's transl)]. | The antianginal effect of three drugs (isosorbide dinitrate-nifedipine-oxprenolol) and of two drug associations (isosorbide dinitrate-oxprenolol; nifedipine-oxprenolol) was studied in six patients, by means of a bicycle ergometer exercise test. The study was double blind; placebo was also included in the test. Treatmen... | 798,709 | [
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0.366919,
0.01513252,
0.2536873,
0.03474185,
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0.0249989,
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0.1227705,
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0.3876418,
0.2390983,
0.04830697,
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0... |
Immunotherapy of human lung cancer with BCG cell-wall skeleton. | Effect of BCG cell-wall skeleton (BCG-CWS) on the recovery of responsiveness of lymphocytes and the survival period was studied in patients with lung cancer. (a) Responsiveness of lymphocytes as demonstrated by proliferative response to phytohemagglutinin (PHA) or microcytotoxicity test with cultured cells of a broncho... | 798,710 | [
0.1532939,
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0.0875087,
0.515034,
0.006621201,
0.338437,
0.5709872,
0.2906159,
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-... |
Current clinical problems of intensive husbandry. | The author performs an examination of the concept of pathocenosis, diseases of groups, and the consequences of the continually increasing unification of microbial populations on a world level. Then the current problems of veterinary assistance on intensive farms are examined and discussed with particular reference to t... | 798,717 | [
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0.2321902,
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0.2938685,
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0.01214548,
0.1362381,
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0.329787,
-0.169510... |
Machine milking: experimental observations on the life of teat-cup liners. | The useful life of neoprene teat-cup liners used in milking machines was determined by physico-mechanical, optical and microbiological studies. The various tests showed that after more than 1,000 hrs' use, that is the milking time plus disinfection time, there were physico-mechanical and biological changes that could h... | 798,719 | [
0.2944824,
0.1192744,
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0.3065107,
0.4602829,
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0.0... |
Clofazimine binding studies with deoxyribonucleic acid. | 1. The antileprosy drug, clofazimine, formed stable complexes with DNA and transfer RNA. A quantitative study was made of the spectral red shifts that occurred when clofazimine interacted with DNA. The red shift appeared specific for clofazimine binding to nucleic acid polymers. 2. The degree of clofazimine interaction... | 798,729 | [
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0.2196601,
0.2531969,
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-0.06211863,
-0.2... |
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