title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Studies of folic acid compounds in nature. IV. Folic acid compounds in soybeans and cow milk. | Folate compounds in soybean and cow's mild were identified by Sephadex chromatography and differential microbiological assaymsoybean contained mainly monoglutamates (ca. 52%), some diglutamates (ca. 16%), and polyglutamates (pentaglutamates representing the major portion). 5-CHO-H4PteGlun(1-6) constituted 65-70% of tot... | 804,977 | [
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Fowl cholera; cross-protective turkey antisera and IgG antibodies induced with Pasteurella multocida-infected tissue bacterins. | Turkey antisera induced with formolized Pasteurella multocida-infected tissues (T antisera) passively cross-immunized 48 of 55 chickens against a challenge dose of P. multocida organisms, from which 0 of 15 controls survived. However, turkey antisera induced with formalin-killed, agar-cultured P. multocida cells (A ant... | 804,994 | [
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Qualitative assessment of midstream urine cultures in the detection of bacteriuria. | 3550 women attending cervical smear and family planning clinics have been screened for bacteriria. Suprapubic aspiration of urine was carried out in 131 patients from whom two consecutive midstream urine specimens contained either a pure growth of Gram positive cocci or a growth in which Gram negative bacilli predomina... | 805,012 | [
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Candida arthritis. A case report and review of the literature. | Candida albicans arthritis is uncommon. Although occasional instances of meningitis, osteomyelitis, endocarditis, pneumonia, and extensive visceral involvement due to Candida species have been reported, only 7 documented cases of arthritis caused by Candida albicans are found in the literature. The present case was an ... | 805,014 | [
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Primary meningococcal pericarditis presenting with tamponade. | An unusual case of a patient with primary meningococcal pericarditis presenting with tamponade is reported. tdespite repeated aspiration and appropriate antibiotic therapy with eradication of group C Neisseria meningitidis, pericardial effusion continued to reaccumulate. Institution of high-dosage corticosteroid therap... | 805,035 | [
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Bioconversion of ribostamycin (SF-733). II. Isolation and structure of 3-N-acetylribostamycin, a microbiologically inactive product of ribostamycin produced by Streptomyces ribosidificus. | The isolation and structure determination of 3-N-acetylribostamycin, a microbiologically inactive derivative, produced enzymatically from ribostamycin by Streptomyces ribosidificus is described. The location of the acetyl group was established by mass and NMR spectrometry of the new compound and its derivatives, and by... | 805,112 | [
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Interaction of Mg-2+ with peptidoglycan and its relation to the prevention of lysis of a marine pseudomonad. | Intact cells of marine pseudomonad B-16 (ATCC 19855) which have been washed with a solution of NaCl require only 0.001 M MgSO4 and 100 to 300 times this concentration of NaCl or KCl to prevent lysis. Conversion of intact cells to mureinoplasts, a process involving removal of the outer double-track layer (outer membrane... | 805,127 | [
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Cell-to-cell binding induced by different lectins. | The cell-to-cell binding induced by concanavalin A (Con A) and the lectins from wheatgerm, soybean, and waxbean has been analyzed by measuring the ability of single cells to bind to lectin-coated cells immobilized on nylon fibers. The cells used were lymphoma, myeloid leukemia, and normal fibroblast cells. With all lec... | 805,150 | [
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Acute haemolytic anaemia due to IgM penicillin antibody in a 3-year-old child: a sequel to oral penicillin. | A hitherto undescribed form of immune haemolytic anaemia due to penicillin antibody is described. The antibody, which was of the IgM class, fixed complement and caused acute haemolysis. Oral penicillin seems to have been responsible both for antibody production and, on subsequent exposure, for the haemolytic anaemia. | 805,165 | [
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Induction and properties of cytotoxic T cells specific for hapten-coupled tumor cells. | Techniques are reported for the induction and assay of cytotoxic effector cells capable of specifically lysing hapten-coupled EL4 leukemia targets. It is shown that EL4 cells survive coupling with TNP-sulfonic acid and retain the hapten on their cell surface for a prolonged period of time. Although TNP-EL4 cells are re... | 805,174 | [
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The role of cutaneous diphtheria infections in a diphtheria epidemic. | Twenty-four people with diptheria and 48 carriers were found in an isolated, circumscribed, rural area during a one-month period. Four patients had cutaneous lesions, which were similar to those of typical impetigo, form which Corynebacterium diptheriae was isolated. These cases constituted an epidemiologic focus from ... | 805,182 | [
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Susceptibility of chicks to experimental infections with Neisseria gonorrhoeae. | Chicks were given intracerebral inoculations of Neisseria gonorrhoeae of colony types 1 or 2 one to two days after hatching. Small numbers ofN. gonorrhoeae initiated lethal infection provided that the body temperature of the animals was not maintained at levels harmful to the microbes per se. The disease process, which... | 805,183 | [
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Effectiveness of achievable urinary concentrations of tetracyclines against "tetracycline-resistant" pathogenic bacteria. | Hospitalized patients with urinary tract infections caused by Pseudomonas aeruginosa or other bacterial pathogens are frequently treated with parenteral antibiotics such as gentamicin. Many of these organisms are shown by Kirby-Bauer disk sensitivity testing to be resistant to tetracycline. One hundred seventy-one such... | 805,188 | [
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Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period. | The comparative development patterns of heme oxidation andof cytochrome P-450 dependent drug oxidation in rat liver were examined. High levels of heme oxygenase activity were present in whole embryo preparations at day 13 of gestation. At birth this enzyme activity in liver was approximately equal to that of normal adu... | 805,210 | [
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Development of ceruloplasmin in pigs during the neonatal period. | Colostrum-free newborn pigs were raised artificially to investigate the appearance of ceruloplasmin in the serum of piglets. The sensitivity of the p-phenylenediamine oxidase activity assay, commonly used as a measure of ceruloplasmin, has been increased 10-fold. Based on this activity, no evidence was found that this ... | 805,216 | [
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Heroin detoxification. A comparison of propoxyphene and methadone. | Propoxyphene napsylate and methadone hydrochloride were each administered under double-blind conditions to 36 outpatients for 21-day heroin detoxification. The initial dosage was 24 mg/day for methadone hydrochloride and 800 mg/day for propoxyphene napsylate. At these dosages, methadone more effectively suppressed the ... | 805,264 | [
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Dealkylation of 24-ethylsterols by Tetrahymena pyriformis. | When Tetrahymena pyriformis was incubated with sitosterol ([24R]-24-ethylcholest-5-en-3 beta-ol]) or its trans-delta22-derivative (stigmasterol), the C-24-dealkylated product, cholesta-5,7,trans-22-trien-3 beta-ol, was obtained in both cases. 24(S)-24-Ethylcholesta-5,7,trans-22-trien-3 beta-ol also was found to be a me... | 805,331 | [
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Ethosuximide in the treatment of absence (peptit mal) seizures. | Thirty-seven patients with previously untreated absence seizures were treated with ethosuximide. Seizures were completely controlled in 7 patients (19 percent); 90 to 100 percent control was achieved in 18 patients (49 percent) and 50 to 100 percent control in 35 (95 percent). Plasma ethosuximide concentration increase... | 805,382 | [
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Effect of aminoglutethimide on serum progesterone and estrogen in the pregnant baboon (Papio SP). | AG was administered orally twice daily for 1 or 3 days to six baboons whose duration of pregnancy ranged from 31 to 99 days. Serum progesterone levels were reduced to as little as 3.2% of the initial concentration in one animal and to 20% or less in four of the five remaining baboons. Serum estrogen levels were depre... | 805,433 | [
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Effects of a health careers program and family support for a health career on eighth graders' career interest. | The separate and combined effects of participation in a health careers program and of parental support for a health career on young people's interest in a health career were examined. Twenty-seven eighth graders participating in a health careers orientation program were matched by sex, race, and parental education with... | 805,452 | [
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Sternal changes following mediastinal irradiation for childhood Hodgkin's disease. | Sternal changes following mediastinal irradiation are described in 78 children with Hodgkin's disease. Incidence and severity of changes are correlated with total sternal dose. Megavoltage irradiation, with a nearly equal absorbed dose ratio between bone and soft tissue, and improved depth dose characteristics, has mar... | 805,461 | [
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Relative doses to skin and superficial nodes from 10 MV photons as a function of field size and distance from shadow tray. | Although low entrance dosea are desirable for cosmetic and tolerance reasons, they may leave the superficial nodes underdosed. Surface dose dependence on area and distance from the shadow tray for 10 MV photons was studied and comparisons made with 60Co and 4 MV energies. The use of 10 MV photons would leave superficia... | 805,462 | [
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Malfunction of linear accelerator dose monitoring systems. | Malfunctions of the dose monitoring systems of two linear accelerators were studied. A variation of plus or minus 2.5% over an air density correction factor range from 1.02 to 1.07 was measured, suggesting that the ionization-type monitor chambers were open to the atmosphere. An average variation of minus 2.0% was pres... | 805,463 | [
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Antibody responses to neonatal immunisation in calves. | Antibody responses were measured in colostrum-fed (CF) and colostrum-deprived (CD) calves immunised at ages varying from birth to four months using a variety of antigens with and without adjuvant. In addition immunoglobulin production in CD calves over the same period was compared with that of CF calves. A marked unres... | 805,467 | [
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Permanent panhypopituitarism associated with maternal deprivation. | A 15-year-old boy with a history of maternal deprivation since age 2 years had severe growth retardation and panhypopituitarism. After one year in an appropriate foster home, there were no changes in his growth rate and pituitary function. This appears to be a case in which panhypopituitarism, probably secondary to mat... | 805,525 | [
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Consequences of microbial contamination during extended intravenous therapy using inline filters. | A study was conducted to determine: (1) the effectiveness of 0.22-mum and 0.45-mum pore size membrane filters in retaining microorganisms over a period of 72 hours of intravenous fluid administration; (2) the growth and multiplication characteristics of microorganisms retained on the filter; and (3) the possibility of ... | 805,533 | [
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Dimethyl sulfoxide in central nervous system trauma. | Dimethyl sulfoxide has been tested in various experimental injuries of the central nervous system in relation to other therapies. It appears to be a useful drug in acute extradural mass-forming lesions, middle cerebral artery occlusion, respiratory anoxia, and spinal cord injuries, in rhesus and squirrel monkeys, dogs,... | 805,558 | [
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Neonatal necrotizing enterocolitis. Evolution of new principles in management. | Over a three-year period, we have operated on 30 infants with necrotizing enterocolitis. Because of the increased experience with this lesion, we have evolved reliable guidelines for both early diagnosis and operative treatment of necrotizing enterocolitis. Initial therapy was nonsurgical in most cases and included gas... | 805,575 | [
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Total intravenous nutrition with peripherally inserted silicone elastomer central venous catheters. | Long-term indwelling central venous catheters inserted peripherally for total intravenous nutrition have been complicated by thrombophlebitis in most instances. However, experiences with silicone elastomer catheters used in this manner have not been previously reported. In this investigation a crank introducer unit has... | 805,577 | [
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Antenatal screening for candidiasis, trichomoniasis, and gonorrhoea. | Gonorrhoea was not found to be a problem in antenatal patients. It was found in only one out of 625 women, thus confirming other British surveys which do not agree with the North American figures. Candidiasis is commoner than trichomoniasis (27.4 and 4.7 per cent. prevalence respectively) and culture of a high vaginal ... | 805,628 | [
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Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria. | This presentation deals with the historical development of the antifolate pyrimidines and related compounds, first as antimalarial substances and later as potent antibacterial agents. It describes the first quantitation of the combined action, through sequential blockade, of the substances with sulfonamides, and outlin... | 805,650 | [
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Comparison of penicillin and trimethoprim-sulfamethoxazole in the treatment of ear, nose and throat infections. | A double-blind trial of penicillin and the combination trimethoprim-sulfamethoxazole was undertaken in adult patients with active infection of the ears, nose or throat. The results indicated that the drug trimethoprim-sulfamethoxazole was as effective as penicillin in achieving clinical improvement and showed a broader... | 805,651 | [
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0.2043936... |
Immunoreactive LH-RH neurons in the hypothalamus identified by light and fluorescent microscopy. | The sites of luteinizing hormone-releasing hormone (LH-RH) neurons and their axonal pathways in the hypothalmi of rats and mice were studied by the immunoglobulin-peroxidase bridge technique and b) the immunofluorescent isothiocyanate technique, using rabbit antiserum to synthetic LH-RH. Both of these techniques give s... | 805,665 | [
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Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature. | The effect of meclofenamate and indomethacin on renal blood flow and renal vascular resistance was determined under basal experimental conditions and during renal ischemia in pentobarbital-anesthetized dogs. Renal blood flow was measured with an electromagnetic flowmeter and renal arterial pressure was recorded from a ... | 805,674 | [
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Carbonic anhydrase isoenzymes in the erythrocytes of new-born premature and full-term infants. | A specific and quantitative immunological method for the determination of human erythrocyte carbonic anhydrase isoenzymes B and C has been used to determine these enzymes in erythrocytes of umbilical cord blood. The investigations have shown a content of both isoenzymes less than 1:10 of that in adults. Premature infan... | 805,677 | [
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Gene flow and selection in a natural population of Drosophila melanogaster. | A marked genetic differentiation to the presence of alcohol in the environment has been shown to occur between inside cellar and adjacent outside sections of a vineyard population of D. melanogaster (McKenzie and Parsons 1974). Estimates of migration during the vintage period suggest considerable movement occurs from o... | 805,758 | [
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Resistance to infection with Nocardia asteroides. | Mechanisms of host resistance to Nocardia asteroides were studied in mice. Two to six weeks after intraperitoneal or intravenous immunization with viable N. asteroides, mice were significantly resistant to intraperitoneal challenge with LD50-100 of N. asteroides in gastric mucin when compared with control (unimmunized)... | 805,811 | [
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... |
[The valence of genetics and exogenous factors in epilepsies of childhood (author's transl)]. | Exogenous and genetic factors must be taken into consideration in the etiology of epilepsy. Exogenous lesions may arise pre-, peri- or postnatally. The effect of genetics on the etiology has previously been suggested by a markedly increased familial occurrence of epileptic patients with seizures, investigations of twin... | 805,908 | [
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[Medical problems of longterm dialysis (author's transl)]. | The number of patients who can be kept alive with the aid of chronic intermittent dialysis increases each year all over Europe. Since the percentage of patients who have dialysis at home is increasing, the general practitioner also contact with the medical complications of these patients. The most common of these probl... | 806,001 | [
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Electrophoretic separation of Bacillus subtilis genes. | The cleavage of Bacillus subtilis DNA by EcoR1 restriction endonuclease produced segments which retain various degrees of genetic transforming activity. The active segments analyzed thus far, range in size from 23 to 3 kilobases and can be partially separated by agarose gel electrophoresis. Various markers can thus be ... | 806,078 | [
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Hammondia hammondi: A new coccidium of cats producing cysts in muscle of other mammals. | Predominant muscle parasitism, and an obligatory two-host cycle (cat-mouse-cat), distinguishes an otherwise similar organism from Toxoplasma. The presence of multiplicative stages in the cat gut separate it from Sarcocystis. Antibody that cross reacts with Toxoplasma antigen is developed in mice and other experimental ... | 806,116 | [
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Treatment of diabetic coma with low-dose hourly intramuscular insulin. | Ten diabetics with severe hyperglycaemia were treated with hourly low-dose intramuscular insulin injections. Five patients were keto-acidotic with a mean initial plasma glucose of 842 mg/100 ml and 5 were non-ketotic with a mean initial plasma glucose of 1 223 mg/100 ml. In every case there was an approximately linear ... | 806,121 | [
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Biologically effective doses from californium-252 intracavitary applications. | Californium-252 which emits fission neutrons and gamma rays is being investigated for applications in brachytherapy. From available experimental results, a value of 6.2 had been arrived at as the RBE for cell killing of californium neutrons relative to radium gavva rays for intracavitary applications based on the revi... | 806,142 | [
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Evaluation of domicilliary management of protein-calorie malnutrition. | An approach to tackle protein-calorie malnutrition through domiciliary management is described. Children suffering from moderate and severe protein-calorie malnutrition were managed using a food supplement containing low cost locally available foodstuffs and nutrition education. An evaluation showed that the anthropome... | 806,153 | [
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Acute retrolental fibroplasia. | A pathologic analysis of 19 cases of acute retrolental fibroplasia in autopsy eyes from paranatal infants is presented. The clinical profile of these subjects showed no clear-cut maternal factors. Infant factors included systemic congenital anomalies (14 cases); ocular congenital anomalies (1); birth weight--less than ... | 806,233 | [
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Betamethasone 17 valerate aerosol and disodium chromoglycate in severe childhood asthma. | Eleven children with severe perennial asthma and a poor clinical response to disodium cromoglycate were studied in a 4-month, double blind trial involving 1 month's treatment with placebo, disodium cromoglycate, betamethasone 17 valerate, and both drugs combined according to a predetermined random design. Each drug app... | 806,293 | [
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Delipidation and reactivation of UDPglucuronosyltransferase from rat liver. | UDPglucuronosyltransferase was solubilized by treating Wistar rat liver microsomes with deoxycholate. Chromatography of this preparation on Bio-Gel P-30 resulted in extraction of 92% of phospholipids and complete loss of enzyme activity. UDPglucuronosyltransferase was reactivated by dialysing this delipidated preparati... | 806,301 | [
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[Ribosomal apparatus of liver cells in the process of carinogenesis induced by 4-dimethylaminoazobenzene]. | A content of membrane-bound and free ribosomes, sedimentation distribution of total polyribosomes in a linear sucrose density gradient and their functional activity in a cell-free system of protein synthesis were estimated in liver of animals feeded with protein-poor rice diet containing a cancerogen, 4-dimethylaminoaz... | 806,307 | [
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Recognition of infection associated with intravenous catheters. | Four cases are described in which the patients suffered from bacteriaemia due to infected intravenous infusions. Although all the patients were pyrexial, the white cell count was normal in all 4 cases at diagnosis and the infusion site appeared innocent. Following removal of the intravenous catheter and the institution... | 806,318 | [
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Possible inhibition of N. gonnorrhoeae by C. albicans. A clinical study. | A probably sifnificant difference (p smaller that 0.05) in the occurrence of gonorrhoea was found between women with and without concomitant C. albicans infection. Although this difference could support the recently reported inhibitory effect by C. albicans on N. gonorrhoeae in vitro another explanation might be the po... | 806,326 | [
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... |
The fine structure of the branched alpha-D-glucan from the blue-green alga Anacystis nidulans: comparison with other bacterial glycogens and phytoglycogen. | The fine structure of the glycogen from the blue-green alga Anacystis nidulans has been examined. After selective hydrolysis of all (1 yields 6)-alpha-D linkages by a bacterial isoamylase, the resulting mixture of linear chains was subjected to gel permeation chromatography. For purposes of comparison, the glycogens fr... | 806,344 | [
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[Action of carbon tetrachloride on the quality of hepatic collagen]. | The collagen, abundantly accumulated in the liver of carbon tetrachloride treated rats, is highly resistant to dissociative agents, indicating a stron cross-linkage. However, even after a very long treatment, such collagen can be resorbed. | 806,392 | [
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Biphasic reaction after inhalation of Haemophilus influenzae in patients with chronic nonspecific lung disease. | In patients with chronic nonspecific lung disease (CNSLD), who had precipitins against Haemophilus influenzae (HI), a biphasic bronchial obstructive reaction is described after inhalation of killed HI bacteria. There was an early obstructive reaction, occurring immediately after the inhalation and lasting for 1 hr, fol... | 806,400 | [
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A brief argument in opposition to the Orgel hypothesis. | The Orgel hypothesis receives considerable attention as a possible explanation for the phenomenon of senescence. Experimental observations which argue in favor of the Orgel hypothesis are discussed, and critized in part. This is followed by a presentation of experimental data which argue in opposition to the notion. On... | 806,486 | [
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Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects. | Using a duodenal perfusion technique, the biliary output of bile acids, phospholipid, and cholesterol was measured hourly during three meals and an overnight fast in seven Caucasians with radiolucent gallstones in a functioning gallbladder, and in seven health controls without gallstones, closely matched for age, sex, ... | 806,491 | [
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0.1883522,
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Characterization of a non-type-specific antigen(s) associated with group A streptococcal type 12 M protein. | The sharing of one and possibly two or more non-type-specific antigens by most strains of groups A, C, and G streptococci is described. With the exception of a single strain of Proteus mirabilis, this antigen(s) was not found among strains of groups B and D streptococci, coagulase-positive staphylococci, Escherichia co... | 806,525 | [
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Studies on Gonococcus infection. IX. In vitro decreased assocation of pilated gonococci with mouse peritoneal macrophages. | Pili, in addition to enhancing attachment of gonococci to tissue culture cells, appear to reduce association (attachment/ingestion) of Neisseria gonorrhoeae with mouse peritoneal macrophages in vitro. | 806,529 | [
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Two pancreas "tissue-specific" antigens in normal human urine, one being and esterase. | Hyperimmune antiserum to human pancreas was exhaustively absorbed with plasma, kidney, and submaxillary gland. The resulting antiserum showed up to seven antigens in pancreas extracts by gel diffusion methods, but failed to react detectably with extracts of 17 other organs and tissues. However, this apparently "tissue-... | 806,537 | [
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... |
The effects of sex and age on serum IgE concentrations in three ethnic groups. | Serum IgE concentrations were measured using a radio-radial immunodiffusion method in 4,440 blood donors resident in the Western Cape Province, South Africa, and the following differences were observed. Firstly, in all three ethnic groups studied, that is the Whites, the Cape Coloureds and the Africans, there was a ten... | 806,538 | [
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Alterations in the lipid content of rat palatal epithelium during carcinogenesis. | The hard palates of 150 female albino rats of the Sprague-Dawley strain were painted 3 times a week either with the fat-soluble carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) for 11 months with inhibited secretion of saliva or with the water-soluble carcinogen 4-nitrochinoline N-oxide (4NQO) for 8 months with intact ... | 806,567 | [
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Pattern formation in the imaginal wing disc of Drosophila melanogaster: fate map, regeneration and duplication. | Fragments of the wing disc of Drosophila (fig. 2) were either injected into mature third instar larvae for immediate metamorphosis, or cultured in adult abdomens for seven days before being transferred to larvae for metamorphosis. The structures differentiated during metamorphosis were then analysed. The results of the... | 806,653 | [
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Differential ability of colonial types of Neisseria gonorrhoeae to produce infection cutaneous perforated plastic chambers in guinea-pigs and rabbits. | Perforated plastic chambers implanted subcutaneously in guinea-pigs and rabbits became encapsulated and filled with sterile transudate. When these chambers in guinea-pigs were inoculated with various strans of Neisseria gonorrhoeae, persistent infections were achieved without the use of anti-inflammation agents and in ... | 806,688 | [
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Acute tropical polyarthritis in Sri Lanka patients. | This paper described the clinical manifestations and laboratory findings in 20 patients with an unusual form of arthritis. All but two were above the age of 20 years (range 14-79). There were eight males and 12 females. The majority of them had fever. All had multi-joint involvement. The erythrocyte sedimentation rate ... | 806,697 | [
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Leptospirosis in Ethiopia: a serological survey in domestic and wild animals. | Seven hundred and fifty-eight serum samples from domestic and wild animals in Ethiopia were tested for leptospiral antibodies by the microscopic agglutination test. The following percentages of seropositivity were obtained: horse (91.3 per cent), cow (70.7 per cent), pig (57.1 per cent), goat (47.3 per cent), sheep (43... | 806,698 | [
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External-bean megavoltage radiation therapy in the treatment of post-radical prostatectomy residual or recurrent tumor preliminary results. | High dose, external-beam megavoltage radiation therapy was administered to 21 patients because of incomplete excision (11 patients) or palpable local recurrence (10 patients) following radical prostatectomy. Of the 21 patients 8 were alive without clinical evidence of cancer for 29 to 97 months after radiation therapy.... | 806,707 | [
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Alpha 1-acid glycoprotein in gastric cancer juice. | Gastric juice was neutralized (nGJ) in vivo by 80 ml of a phosphate buffer containing radiolabelled vitamin B12 as dilution indicator. Unprocessed nGJ was analyzed in the double gel diffusion technique for the presence of serum proteins using monospecific antisera. Alpha1-Acid glycoprotein (AGP) was found in a high inc... | 806,743 | [
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Chemical determination of protein neighbourhoods in a cellular organelle. | Experimental procedures developed for the identification of near-neighboring proteins in a complicated organelle are described in this paper. The specific system studied here is the ribosome of Escherichia coli; however, the techniques and reagents described should have a wide range of applications. We have used three ... | 806,784 | [
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[Determination of blood alcohol in persons with blood diseases and secondary distrubances of the blood pictures]. | The distribution of alcohol in the blood is determined by the water content of serum and whole blood. In order to verify the conversion factor qu for the establishment of the "blood alcohol concentration" from the alcohol content of the serum, the serum protein content, the hematocrit and the water content of the serum... | 806,786 | [
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Influence of glyceryl trinitrate on force of contraction and action potential of guinea-pig myocardium. | 1. The inotropic effect of glyceryl trinitrate (GTN) was studied in guinea-pig papillary muscles and atrial strips by analysing the isometric contraction curve and the monophasic action potential (AP). 2. GTN, 7X10(-5)M in papillary muscles and at 1.4x10(-4)M in atrial strips. The maximum of the contractile force was r... | 806,816 | [
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[Clinical results of an extensive gut resection in newborn infants]. | Clinical experience over the last 20 years in neonates and infants with the short-gut syndrome is reviewed. In this period there has been considerable development with respect to the problem. Today one can say that, basically, all children (even those with only a few cm of small intestine) can be kept alive by means of... | 806,874 | [
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[Nosema sp. in white rats]. | In 14 days after the intraperitoneal infection of mice with 30% brain emulsion of white mice or of newly-born rats in the peritoneal liquid there were found spores of Nosema sp. 5.37 plus or minus 0.88 x 3.04 plus or minus 0.07 in size. The subsequent attempts to passage this organism on the mice by adminestering into ... | 806,876 | [
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0.110268... |
[Cytophotometric studies of the nuclear cycle of Sphaeromyxa elegini]. | The cytophotometric investigation of DNA content in the nuclei of Myxosporidia Sphaeromyxa elegini Dogiel 1948 was made. It was found that not only nuclei of sporoplasm but also capsulogenic nuclei are haploid. The fact makes us leave apart, as far as these species are concerned, the scheme of nucl eic cycle according ... | 807,002 | [
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Cytochemical localization of adenyl cyclase in the rat colonic mucosa. | Adenyl cyclase has been demonstrated in the colonic mucosa with the aid of adenylyl-imidodiphosphate as a specific substrate. Coarse precipitates are located mainly in the basement membrane and in the junctional area between two epithelial cells and on the brush border of all epithelial cells of the descending colon. H... | 807,029 | [
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Myelodysplasia. Problems of long-term survival and social function. | Problems of ninety-eight patients with myelodysplasia, ages 13 to 72, were reviewed. They were grouped as follows: Those having thoracic and high lumbar level (L(2) upward arrow) lesions and confined to wheel chairs, those with intermediate paralysis (L(3-5) nerve roots) as walking with aids and those with less paralys... | 807,042 | [
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0.0265528... |
Observations on the histomorphology of sarcosporidian cysts of some East African game animals (Artiodactyla). | The histomorphology of formalin-fixed micro and macrosarcosporidian cysts of Grant's, Thomson's gazelle, impala, wildebeest, Bubal hartebeest, Cape eland, red duiker, Kirk's dik-dik, defassa waterbuck, Bohor reedbuck, African buffalo, giraffe, warthog, and giant forest hog is described. The wall of microsarcosporidian ... | 807,047 | [
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[Typing of pseudomonas aeruginosa by pyocine production. Experiments with a simplified method using four indicator strains (author's transl)]. | A further differentiation of strains of Pseudomonas aeruginosa which have been isolated from clinical material is desirable because of the increasing frequency of hospital infections caused by this species. Only by such a procedure cross infections which require hygienic measures can be distinguished from autoinfection... | 807,054 | [
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Insoluble PHA- A B-cell mitogen in man? | Blood lymphocytes of normal individuals and of patients with chronic lymphocytic leukemia were evaluated for their blastogenic response to insoluble PHA. In at least preferential stimulation of normal B-lymphocytes was observed, whereas leukemic lymphocytes were almost insensitive. This result supports the hypothesis o... | 807,072 | [
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Lymphocytes devoid of T and B cell markers in chronic lymphatic leukemia. | Peripheral lymphocytes of 16 patients with chronic lymphatic leukemia were studied for B and T cell markers with peroxidase-labelled anti-immunogloulin antisera and complement and spontaneous rosetting techniques. Increased numbers of B cells and normal numbers of T cells were noted. A significant observation was the p... | 807,073 | [
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... |
[A case of atypical myeloblasts; a RNA leukemia]. | In a 53-year-old female patient, a tumor localized in the nasopharyngeal cavity together with hematologic features of acute paramyeloblastic leukemia were observed. More than 70% blast cells contained giant intracytoplasmic inclusions which have been found to be strongly pyroninophilic. The electron-microscopic study r... | 807,075 | [
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Cross-linking and coupling of rabbit muscle aldolase and glyceraldehyde-3-phosphate dehydrogenase by glutaraldehyde. | The mode of cross-linking of rabbit-muscle aldolase and glyceraldehyde-3-phosphate dehydrogenase by glutaraldehyde was studied. The about 5 A long reagent can partly cross-link subunits within the tetramers, whereas it is readily able to make intermolecular cross-links producing polymeric enzyme species. Of the two enz... | 807,079 | [
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Plasma vitamin A, retinol-binding protein and prealbumin concentrations in protein-calorie malnutrition. III. Response to varying dietary treatments. | Plasma vitamin A, retinol-binding protein, and prealbumin concentrations have been studied in 38 northern Thai children with protein-calorie malnutrition (PCM). The 4-week study period consisted of 1 week of stabilization followed by 3 weeks of treatment with formula diets varying in their protein and calorie content. ... | 807,094 | [
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... |
Experimental production of elevated serum folate in dogs with intestinal blind loops. II. Nature of bacterially produced folate coenzymes in blind loop fluid. | Jejunal and ileal blind loops were constructed in separate groups of dogs and the folate coenzymes present in these loops were investigated. Although only those dogs with high blind loops had appreciably elevated folate levels active for Lactobacillus casei but not Streptococcus faecalis, every blind loop appeared to c... | 807,096 | [
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Meningococcal pneumonia. | A patient with meningococcal pneumonia which developed following therapy for an earlier episode of pneumococcal pneumonia is presented. This entity is most frequently associated with an antecedent viral respiratory illness and/or a concurrent infection with Hemophilus influenzae or diplococcus pneumoniae. The character... | 807,105 | [
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New hominids from East Rudolf, Kenya, I. | Important new hominid fossils from the Plio-Pleistocene sediments of Lake Rudolf, Kenya, are described. They include: a partial, adult cranium with most of the calvaria and some of the facial skeleton preserved; a complete right femur; and bones of a single left lower limb--femur and upper and lower parts of the tibia ... | 807,114 | [
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The emergency management of diabetes mellitus. | Some of the acute metabolic derangements of unstable diabetes have been discussed. The management of patients undergoing surgical operations has also been considered. No problems are usually encountered in diabetic patients treated with diet alone or with oral hypoglycaemic compounds, although chlorpropamide may need t... | 807,120 | [
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Serum complement and immunoconglutinin in malnutrition. | Serum haemolytic complement activity and C3 were significantly decreased in 35 malnourished children. The changes were more pronounced in those with infection. Electrophoretically altered forms of complement C were detected in 14. There was an inverse correlation between C3 levels and immunoconglutinin titres. Nutritio... | 807,166 | [
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Studies on stimulation and properties of antiglobulin antibodies. I. Influence of heatig at 56 degrees C and 60 degrees C on antigenicity. | The autoimmunogenic properties of whole rabbit serum heated at 56 degrees C and 60 degrees C were studied in rabbits. Autologous rabbit serum heated 20 min at 60 degrees C was immunogenic. The state of induced immunity manifested itself by the appearance of antibodies to antigens of heterologous sera: human, goat and g... | 807,178 | [
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Successful long-term intravenous hyperalimentation in the hospital and at home. | Experience with long-term intravenous hyperalimentation in the hospital and at home in one patient over a 22-month period is reported. After multiple operative procedures the patient was left with only her stomach, duodenum, and 5 cm of the proximal part of the jejunum. During a 12-month period in the hospital, despite... | 807,181 | [
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Role of cell membrane galactosyltransferase in concanavalin A agglutination of erythrocytes. | It has been previously observed that rabbit erythrocyte cell surface galactosyltransferase appears to play a role in concanavalin A agglutination of these erythrocytes (Podolsky et al., 1974). Further, a correlation between the occurrence or level of cell surface galactosyltransferase and concanavalin A agglutinability... | 807,201 | [
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Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. | 1. The interaction of insulin and isometric exercise on glucose uptake by skeletal muscle was studied in the isolated perfused rat hindquarter. 2. Insulin, 10 m-i.u./ml, added to the perfusate, increased glucose uptake more than 10-fold, from 0.3-0.5 to 5.2-5.4 mumol/min per 30g of muscle in hindquarters of fed and 48h... | 807,202 | [
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Feto-maternal haemorrhage following successful and unsuccessful attempts at external cephalic version. | In the present study, 6 out of 100 patients who had an attempted or actual external cephalic version (ECV) showed significant feto-maternal haemorrhage, the amount being greatest in patients with "failed" external versions. Thus ECV may be a source of rhesus iso-immunization in a rhesus negative mother with a rhesus p... | 807,231 | [
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Bovine adrenal medullary chromogranin A: studies on the structure and further evidence for identity with dopamine-beta-hydroxylase subunit. | 1. Chromogranin A was purified by the use of polyacrylamide gel electrophoresis. The amino acid composition of chromogranin A appeared to be nearly identical to that reported by other investigators and, moreover, was confirmed to be similar to that of dopamine beta-hydroxylase. 2. Dansyl-end group analysis revealed the... | 807,250 | [
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Studies on DNA repair in Bacillus subtilis. I. A cellular factor acting on gamma-irradiated DNA and promoting its priming activity for DNA polymerase I. | Initiation of new DNA synthesis was observed in B. subtilis cells upon gamma-ray irradiation followed by toluene treatment and incubation in the presence of the four deoxynucleotide triphosphates and Mg2+. This DNA synthesis took place in the absence of ATP and was refractory to 6-(p-hydroxyphenylazo)-uracil which is a... | 807,254 | [
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The effect of sulphide on cytochrome aa3. Isosteric and allosteric shifts of the reduced alpha-peak. | 1. Sulphide, like cyanide, is a slow-binding inhibitor of cytochrome aa3 with a high affinity (KD smaller than 0.1 MUM). 2. Unlike cyanide binding, the binding of sulphide is apparently independent of the redox state of components of the oxidase other than cytochrome a3 and shows no anomalous kinetics during complex fo... | 807,256 | [
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Fluorescence induction in intact spinach chloroplasts. | Under conditions in which the Photosystem II quencher is rapidly reduced upon illumination, either after a preillumination or following treatment with dithionite, the fluorescence-induction curve of intact spinich chloroplasts (class I type) displays a pronounced dip. This dip is probably identical with that observed a... | 807,257 | [
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Clinical and immunologic features of selective IgA deficiency. | Selective absence of serum and secretory IgA is probably the most common form of human immunodeficiency. High frequencies of recurrent sinusitis, otitis media, pneumonia, and atopy were noted among a group of 75 such patients, all but 4 of whom were Caucasian. Seven instances of familial absence of IgA were detected am... | 807,270 | [
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Uteroglobin and other proteins in rabbit blastocyst fluid after development in vivo and in vitro. | Rabbit embryos were grown in vitro from the 2- and 4-celled stage to expanded blastocysts. Proteins from the blastocysts were analyzed for specific uterine proteins as well as for bovine serum albumin (BSA), a constituent of the medium. Immunological methods revealed the presence of rabbit albumin and larger amounts of... | 807,328 | [
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[The effect of prostaglandins E1 and A2 on the proliferation and phagocytosis of mouse peritoneal macrophages in culture]. | The action of prostaglandins E1 and A2 was studied on the proliferation and the phagocytosis of mouse peritoneal macrophages in culture. The proliferation was not stimulated by prostaglandins E1 and A2, but the phagocytosis was increased by prostaglandin A2 and decreased by prostaglandin E1. These actions could be corr... | 807,345 | [
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[The sex-trapping of Sterrha biselata (Hufn.) (Lepidoptera Geometridae, Sterrhinae) by acetoxy-1 dodecadiens-7 E, 9Z, the sex pheromone of Lobesia botrana (Schiff.) (Lepidoptera Tortricidae, Olethreutinae)]. | 7E, 9Z dodecadienyl acetate, a sex-heromone for Lobesia botrana, is selectively attractive, in vineyards, for males of this species. By testing this compound in woods and orchards, we have found that it was also selectively attractive for males of a geometrid moth; Sterrha biselata. This is one of the first examples wh... | 807,350 | [
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[Plasma testosterone and LH levels in the male lamb from birth to puberty]. | In peripheral plasma of male lambs testosterone increase was linear from birth to 100 days; after it reached a plateau without clear relationships with puberty. Plasma LH pattern was also linear during the first 70 days. During this period testosterone and LH were significantly correlated (r equals 0,85). | 807,351 | [
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