title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Effectivity control of medical postgraduate training courses (author's transl)]. | A pilot study of 185 participants of a seminar congress on psychosomatic gynecology was intended to examine how far effectivity controls are feasible. The seminar assessment was age-dependent e. g. with regard to presentation of material (p less than 0.01) and practical usefulness (p less than 0.05). The assessment was... | 105,282 | [
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Failure to thrive associated with renal disease. | Failure to thrive is a clinical syndrome usually associated with severely reduced increments in height and weight. It is commonly present in patients with chronic renal failure and occurs occasionally in patients with recurrent urinary-tract infections or tubular disorders. Renal osteodystrophy, protein-calorie malnutr... | 105,338 | [
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An unusual complication of subclavian vein catheterization for total parenteral nutrition. | A 25-year-old woman with diabetic ketoacidosis and esophagitis was given total parenteral nutrition to improve her nutritional status. A central venous catheter inserted in the right subclavian vein was well tolerated for three weeks, when infection developed. The line was replaced by a left subclavian line. Within an ... | 105,346 | [
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DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats. | Endonuclease EcoRI-digested DNAs from BALB/c mouse embryos and MOPC 321 (a kappa chain secretor) myeloma were fractionated by agarose gel electrophoresis, and the DNA fragments containing part or all of the MOPC 321 kappa chain structural gene sequences were visualized by the Southern gel blotting technique using as th... | 105,355 | [
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Plasmodium knowlesi-induced antigens in membranes of parasitized rhesus monkey erythrocytes. | Highly purified Plasmodium knowlesi schizonts were used to produce a hyperimmune anti-parasite serum in a rhesus monkey. Proteins of membranes from normal and P. knowlesi-infected erythrocytes, as well as purified schizonts, were solubilized in 1% Triton X-100 and analyzed by bidimensional electrophoretic techniques. O... | 105,359 | [
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Parenteral nutrition in toxic septic states. | An analysis is made of two groups each of 20 patients with toxic septic states and hypercatabolic renal failure, who were given parenteral nutrition for at least 3 days. Each group was divided into two subgroups, given glucose, 13--20 and 20--27 kcal. 24 h--1 kg--1 body weight; the second subgroup was also given nitrog... | 105,385 | [
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[Effect of polychlorinated biphenyls in the rat. III - PCB distribution, storage and elimination relation time (author's transl)]. | The study of accumulation and elimination of Phenoclor DP6 (a commercial PCB mixture) was carried out in three experiments : 1) Rats were fed diet containing 100 ppm of DP6 and were sacrificed after 1, 3, 8, 15 and 30 days. 2) Rats fed DP6 diet during 15 days were subsequently fed with a control diet and sacrificed 8, ... | 105,428 | [
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The McCormick Family Planning Program in Chiang Mai, Thailand. | The McCormick Family Planning Program is a private, single-purpose program that has been offering contraceptive services to women in largely rural Chiang Mai province in Northern Thailand since 1963. In addition to two clinics in Chiang Mai city, the program operates a mobile unit, which visits service points throughou... | 105,432 | [
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Purine nucleotide metabolism in promastigotes of Leishmania tropica: inhibitory effect on allopurinol and analogues of purine nucleosides. | The catabolism of adenosine 5'-monophosphate in promastigotes of L. tropica suggests the presence of a parasite specific pathway. In continuing the investigation on enzymes of this pathway two purine nucleoside cleaving enzymes have been found, adenosine phosphorylase and inosine nucleosidase. Various purine nucleoside... | 105,434 | [
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Ruthenium red binding to cell coat in neoplastic neurogenic cell lines in culture. | The cell coat of cultivated fetal rat brain cells as well as malignant rat neurogenic cell lines in culture were studied by transmission electron microscopy with the ruthenium red staining technique. Some of the transformed cell lines demonstrated alteration in the bindng properties of ruthenium red to the cell surface... | 105,464 | [
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[Platelet function during long term inhibition of labour by fenoterol/verapamil (author's transl)]. | Platelet function has been studied in 22 patients (methods according to Born and Breddin) during tocolysis with long term administration of intravenous Fenoterol/Verapamil. The extend and speed of platelet aggregation, according to the Born test, were constant in the following 12 days except for a small increase on the... | 105,482 | [
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Nitrates and ectopic ventricular activity in mitral valve prolapse: clinical and experimental data. | Three patients with mitral valve prolapse, high grade ventricular arrhythmias and a strong family history of sudden death were studied utilizing continuous Ecg monitoring and intracardiac stimulation and recording techniques. Analysis of 6-hour ambulatory Ecgs revealed frequent premature ventricular beats (PVBs) includ... | 105,483 | [
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[Treatment of impending and manifested respiratory distress syndrome in newborn infants using a simple nasal CPAP-system]. | The modification of a simple nasal CPAP-system is described. Results in therapy of respiratory distress syndrom with this method are discussed. | 105,508 | [
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Isolation and properties of enzymes involved in prostaglandin biosynthesis. | Prostaglandin (PG) endoperoxide synthetase was purified until homogeneity had been attained. The pure enzyme displays both cyclooxygenase and peroxidase activity, in accordance with the work of MIYAMOTO et al. (J. biol. Chem. 252, 2629--2636 (1976)). This enzyme therefore converts arachidonic acid into PGH2. Glutathion... | 105,525 | [
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Suppression of uterine motor activity by prostaglandin synthetase inhibitor Naproxen. | Rats were ovariectomized on day 16 of pregnancy and they were fitted with a pressure sensor uterine microballoon assembly and were given a daily dose of Naproxen-sodium. Daily uterine activity recordings were taken and subjected to statistical analysis and the rats were carefully checked for either aborting or deliveri... | 105,529 | [
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[Pulse cytophotometrical investigations about the resistance of DNA against acid hydrolysis influenced by ageing and cortisol (author's transl)]. | The resistance of nuclear chromatin against acid hydrolysis with hydrochloric acid was studied in cell nuclei of different organs from young and old rats and after application of cortisol. Suspensions of cell nuclei from liver, spleen, kidney, heart muscle and mucosa from small intestine were stained with ethidium brom... | 105,551 | [
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[Some notes on the specifity of the fluorescence histochemical demonstration of GABA (author's transl)]. | The distribution of the GABA in the Purkinje cells of the rat cerebellum was demonstrated by means of modified fluorescence histochemical method according to WOLMAN (1971). Three types of Purkinje cells, with respect to their fluorescence intensity and GABA distribution, were evident. The GABA-fluorescence was striking... | 105,559 | [
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Preliminary results in the immunization of Irus monkeys against dental caries. | Twelve Irus monkeys were divided into four groups which were immunized with placebo, two cell wall preparations and one vaccine containing a glucosyltransferase preparation of S. mutans. After 310 days of challenge by a cariogenic diet, the caries score in all the immunized animals was below that of the controls. Furth... | 105,573 | [
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Stability of oral liquid penicillins in unit dose containers at various temperatures. | The effect of freezing on the stability of reconstituted, unit dose packaged oral amoxicillin trihydrate and ampicillin suspensions and penicillin V potassium solutions was studied. Powders for suspension or solution of the three penicillins were reconstituted according to manufacturers' directions to yield a concentra... | 105,636 | [
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[The emergency treatment of a recent burn of the oesophagus (author's transl)]. | The emergency treatment of an oesophageal burn consist of: -- avoidance of a certain number of measures which may be considered to be dangerous or useless: gastric lavage, emetic agents, neutralising agents or oesophageal antacids; -- the treatment of shock and of oesophageal and gastric complications, in cases of mass... | 105,660 | [
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Brucella cultures typed by the Who Brucellosis Centre at the Commonwealth Serum Laboratories, Melbourne. | Results of the typing of Brucella cultures received at the WHO Brucellosis Centre, CSL, Melbourne, from 1968-1976 are presented. The distribution of the biotypes of cultures recovered throughout Australia is shown on a host and State basis and atypical cultures are discussed. Cultures identified from Australia were Br.... | 105,700 | [
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Affinity labelling with a deaminatively generated carbonium ion. Kinetics and stoicheiometry of the alkylation of methionine-500 of the lacZ beta-galactosidase of Escherichia coli by beta-D-galactopyranosylmethyl-p-nitrophenyltriazene. | 1. beta-D-Galactopyranosylmethyl-p-nitrophenyltriazene is an active-site-directed irreversible inhibitor of Mg2+-bound and Mg2+-free lacZ beta-galactosidase from Escherichia coli. 2. The Mg2+-enzyme binds the inhibitor more tightly but the complex then decomposes less rapidly than is the case with Mg2+-free enzyme. 3. ... | 105,721 | [
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Extracellular labeling of growing secreted polypeptide chains in Bacillus subtilis with diazoiodosulfanilic acid. | Studies of the mechanism of protein secretion in a Gram-positive bacterium, Bacillus subtilis, yielded results very similar to those previously obtained with a Gram-negative organism: nascent chains protruding from protoplasts could be labeled extracellularly; the labeled chains could be recovered on polysomes isolated... | 105,750 | [
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Structural and antigenic studies of an idiotype-bearing murine antibody to the arsonate hapten. | Mice of strain A/J responded to repeated intraperitoneal injection of Limulus hemocyanin derivatized with arsanilic acid by producing large quantities (approximately 5 mg/mL of ascites fluid) of IgG antibodies specific for this hapten. The antibodies possessed a characteristic idiotypic determinant and exhibited restri... | 105,755 | [
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Early postoperative feeding with elemental diet. | The value of early postoperative feeding with an elemental diet was assessed in 30 patients after major gastrointestinal operations. The patients were allocated at random to conventional treatment (control group) or feeding with the elemental diet (ED group). The clinical and metabolic course of the 15 patients in the ... | 105,777 | [
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Origin of the fornix system in the squirrel monkey. | Wit the use of the horseradish peroxidase retrograde axonal transport technique this experiment attempted to identify the cell bodies of origin whose axons supply the septal area, mammillary bodies and the anterior thalamic complex in the squirrel monkey. It was noted that axons which innervate the anterior thalamic co... | 105,779 | [
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Nucleolar changes in response to dietary protein malnutrition in the neurons of the motor cerebral cortex and cerebellum of squirrel moneky Saimiri sciureus. | Nucleolo-cytoplasmic relationships have been studied in healthy squirrel monkeys and those subjected to a known degree of protein malnutrition. In the latter group, thirty-two pregnant animals starting from 35 days of gestation and 24 young adult animals were given a diet containing 7.5% and 2.0% protein content, respe... | 105,809 | [
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[Purfication and molecular weight of an RNA-dependant RNA polymerase from Brassicae oleracea var. Botrytis]. | An RNA-dependent RNA polymerase has been completely purified from Cauliflower inflorescences. Analysis of the purified enzyme on SDS-polyacrylamide gels showed one polypeptide chain with a molecular weight of 140,000 dalton. The enzyme is monomeric in its native state. The in vitro activity was completely dependent on ... | 105,817 | [
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0.01492196,
0.2338116,
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0.02000579,
0.1979298,
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-0.02637628,
-0.07609933,
0.2417238,
0.2531506,
-0.02279353,
0.538421,
-0.0008289808,
-0.427647... |
[Experimental cholera in monkeys]. | The immune response to Vibrio cholerae was studied in baboons, rhesus monkeys and marmosets inoculated by the oral, intraintestinal or intravenous route with various strains of V. cholerae. Sera were collected from all animals on days 2, 6, 10, 17, 24, 32, 45 and 60 after infection. Serum protein, immunoglobulins (IgA,... | 105,813 | [
0.01404306,
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0.03875661,... |
Pharyngocutaneous fistulae following total laryngectomy. | Postoperative pharyngocutaneous fistula formation is a troublesome complication in head and neck surgery and occurred in 8 out of 53 patients following a total laryngectomy (15%). The incidence falls within the lower range of that reported in the literature (6-66%). Different factors which may influence the formation o... | 105,826 | [
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... |
Comparison of placebo, nitroglycerin, and isosorbide dinitrate for effectiveness of relief of angina and duration of action. | Each of 13 patients with angina had either chewable isosorbide dinitrate, nitroglycerin (sublingual therapy), or placebo administered on each of three different days when mild anginal pain had been induced by walking on a treadmill. Both therapy with isosorbide dinitrate and therapy with nitroglycerin were effective in... | 105,834 | [
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0.2599159,
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0.1940763,
0.1084933,... |
Effect of somatostatin on parathyroid hormone and calcitonin secretion. | This study evaluated the effect of somatostatin on immunoreactive parathyroid hormone (iPTH) and calcitonin (iCT) secretion in vivo in rats and monkeys and on iPTH secretion in vitro by normal bovine parathyroid tissue and by a human parathyroid adenoma. Somatostatin infusion promptly (within 0.5 h) suppressed both iPT... | 105,871 | [
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0.08423431,
0.1888626,
0.1767534,
0.4798613,
0.07832001... |
Gonadotropin releasing hormone release from the rat hypothalamus: dependence on membrane depolarization and calcium influx. | Release of gonadotropin-releasing hormone (GnRH) was studied by incubating individual rat hypothalami for 60 min, after a 30-min preincubation period, and measuring GnRH in the medium by immunoassay. During the 1 h of incubation, endogenous GnRH release was linear and exogenous GnRH was not destroyed. Membrane depolari... | 105,888 | [
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0... |
The effect of L-DOPA administration on thyrotropin (TSH) and thyrotropin releasing hormone (TRH) levels in serum in primary or pituitary hypothyroidism. | The effect of acute administration of L-DOPA on TSH and TRH levels in serum was studied in primary or pituitary hypothyroidism. TRH levels in serum fell and then returned to initial levels after L-DOPA administration in primary or pituitary hypothyroidism. TSH levels in serum fell and then returned to initial levels af... | 105,899 | [
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0.06843807,
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0.1567741,
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The relation between insulin and adipocyte insulin receptors during treatment of human obesity. | Seventeen obese patients were submitted to 1 week's severe then 3 months moderate dietary restriction. The glycaemic and insulinaemic response to oral glucose was measured at baseline, after 1 week and at 3 months, and the results related to adipocyte insulin receptors estimated from fat biopsies taken on each occasion... | 105,908 | [
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0.1183375,
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Studies on the turnover of endogenous cathodal trypsinogen in man. | The concentration in serum of cathodal trypsinogen has been studied in certain clinical and experimental situations. The concentration correlated with pancreatic amylase activity. Low levels were found in patients with malabsorption due to exocrine pancreatic insufficiency. The concentration rose after endoscopic retro... | 105,910 | [
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0.09255492,
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0.2865457,
-0.094588... |
Blood-brain barrier permeability during shortlasting intravascular hyperosmolality. | Blood-brain barrier permeability for 24Na+ and 36Cl- ions and for 3HOH was studied during isoosmolality and during shortlasting intravascular hyperosmolality in twenty-five patients using the double indicatir single injection method. Hyperosmolality was induced by a rapid injection into the internal carotid artery of 8... | 105,911 | [
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0.2788725,
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0.05768168,
0.1988325,
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Effect of muscle spasms on blood gases and acid-base status in tetanus patients. | Blood gas tensions and acid-base status were determined in six patients with tetanus before and after the onset of severe muscle spasms. Hypoxaemia and metabolic acidosis present in all the patients, were worsened by muscle spasms. It is suggested that frequent measurements of blood gases should be carried out where su... | 105,916 | [
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0.1885224,
0.1345876,
0.201911,
0.2124117,
-0.1380082... |
I. Functional properties of neurons in lateral part of associative area 7 in awake monkeys. | The lateral part of area 7, area 7b, of alert, behaving macaque monkeys was investigated using transdural microelectrode recording technique. Two hundred twenty-eight cells from five hemispheres of four monkeys were isolated and studied. The functional properties of 2% of the cells isolated remained unidentified. Funct... | 105,918 | [
-0.03196942,
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0.01753643,
0.06852917,
0.4888967,
0.2377345,
0.0505390... |
The cingular vocalization pathway in the squirrel monkey. | In 39 squirrel monkeys (Saimiri sciureus), the effects of various brain lesions on vocalizations elicited from the precallosal cingulate gyrus were tested. It was found that lesions abolishing the "cingular vocalization" completely can be traced from the stimulation site continuously down to the laryngeal motoneurons i... | 105,921 | [
-0.08810735,
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0.2763922,
0.2345362,
0.02799242,
... |
[Piecewise Fourier analysis of images and the role of the occipital, temporal and parietal cortex in visual perception]. | On the basis of previously published data, a neuronal scheme of organization of the visual perception in the cerebral cortex, is suggested. An idea of neuronal module is introduced: a cylinder of cortical neurons whose receptive fields are directed towards the same area of the visual field and respond to different spat... | 105,939 | [
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0.09250479,
0.3303353,
0.3407845,
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... |
Regulation of newly evolved enzymes. IV. Directed evolution of the Ebg repressor. | In Escherichia coli, the wild-type repressor of ebg (evolved beta-galactosidase) enzyme synthesis, specified by the ebgR+ gene, responds very weakly to lactulose (fructose-beta-D-galactopyranoside). Selection for a functional repressor that responds strongly to lactulose as an inducer reveals the existence of ebgR+L mu... | 105,963 | [
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0.4903059,
0.1358912,
-0.17137... |
Inhibition of photo-induced Trichoderma viride conidiation by inhibitors of RNA synthesis. | The photo-induced conidiation of Trichoderma viride is suppressed by ethidium bromide, acriflavin, lomofungin and 8-quinolinol at concentrations which do not inhibit the colony growth of this deuteromycete. | 105,976 | [
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0.3735546,
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0... |
Canada's NHI: a physician's evaluation. | A physician in Manitoba reports that a national health care system has worked well in Canada, particularly for poor people and for governments concerned about the equitable and universal delivery of health care, as well as about rising health costs. Physicians, however, find the greatest problems are their own low sala... | 105,983 | [
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0.1559022,
0.20... |
Microscopic characterization of rabbit lung damage produced by Pseudomonas aeruginosa proteases. | The intratracheal administration of highly purified Pseudomonas aeruginosa proteases (ca. 10 to 100 microgram) elicited extensive, grossly observable rabbit lung damage by 3 h postinjection. Light and electron microscopic characterization of the lesions revealed: (i) progressive injury and necrosis of type I epithelial... | 106,001 | [
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0.5940137,
0.07870943,
-0.02495839,
0.4300796,
0.06891... |
Anticomplementary activity of tuberculin: relationship to platelet aggregation and lytic response. | Experiments were performed to examine the interaction of tuberculin with platelets and complement. Hemolytic complement titrations show that tuberculin consumes complement in human, rabbit, and guinea pig serum. Evidence in support of classical pathway activation was provided by observation of C1 consumption and failur... | 106,002 | [
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0.4764399,
0.3897897,
0.3934288,
-0.008122... |
Defective cellular immunity to gram-negative bacteria in cystic fibrosis patients. | In vitro lymphocyte responses to Pseudomonas aeruginosa have been found to be impaired in cystic fibrosis patients with advanced clinical disease. The responses to Klebsiella pneumoniae, Serratia marcescens, and Proteus mirabilis were studied in a similar group of cystic fibrosis patients and normal individuals. Cystic... | 106,011 | [
-0.001865447,
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-0.05979778,
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0.2007317,
-0.03615639,
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0.1048537,
0.03864807,
0.380508... |
Implications of aldose reductase in cataracts in human diabetes. | Cataracts removed intracapsularly by cryoprobe technique from human diabetics were analyzed for sugars and polyols by gas liquid chromatography. The contents of sorbitol and fructose of lenses followed blood glucose levels at least up to 250 mg/dl. Studies indicate that human lens is capable of synthesizing substantial... | 106,020 | [
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0.02825816,
-0.256071,
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0.1238716,
0.05292882,
0.3043908,
0.5080438,
-0.02487483,
... |
Preservation and storage of pathogenic Neisseria. | Pathogenic species of Neisseria, especially N. gonorrhoeae are notoriously difficult to maintain in a viable state for long storage periods. Frequent transfer of cultures on artificial media and storage at 4 to 8 C quickly leads to loss of viability and virulence and to changes in antigenicity. Freeze-drying has been r... | 106,024 | [
-0.3128679,
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0.2431379,
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... |
Lack of response to vitamin D therapy in a patient with hypoparathyroidism under anticonvulsant drugs. | Case report of a 16-year-old boy suffering from idiopathic hypoparathyroidism with severe seizures who erroneously and unsuccessfully had received anticonvulsive therapy for 12 years. When the correct diagnosis was made, treatment with massive doses of vitamin D2 was started. However, this treatment became effective on... | 106,028 | [
-0.3340812,
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0.00949397,
-0.01741763,
-0.1982869,... |
Two forms of nitrogenase from the photosynthetic bacterium Rhodospirillum rubrum. | Acetylene reduction by nitrogenase from Rhodospirillum rubrum, unlike that by other nitrogenases, was recently found by other investigators to require an activation of the iron protein of nitrogenase by an activating system comprising a chromatophore membrane component, adenosine 5'-triphosphate (ATP), and divalent met... | 106,042 | [
-0.1807285,
-0.08939866,
0.07242657,
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-0.3066577,
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-0.007255211,
0.05780958,
0.09580944,
0.1283177,
-0.01029006... |
Regulation of RNA synthesis in Tetrahymena pyriformis: secretion of regulatory factors. | The rate of ribosomal RNA synthesis varies greatly with the population density in both exponentially and synchronously growing populations of Tetrahymena pyriformis. Shortly after inoculation of the population - at relatively low cell densities - a gene-dose effect dominates the picture, and a doubling in the gene numb... | 106,059 | [
-0.1682363,
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0.1757961,
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0.1861181,
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0.2219624,
0.6013248,
0.2278019,
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0.0... |
Mechanisms of cellular adhesion. IV. Role of serum glycoproteins in fibroblast spreading on glass. | We have investigated the exogenous factors required for the transition from the round shape of suspended fibroblasts to the characteristic spread shape on serum-coated glass. Following the evidence of others that the transition is facilitated by adsorbed component(s) related to CIG/LETS (cold-insoluble globulin/large e... | 106,061 | [
-0.1065989,
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0.4153627,
0.3939444,
0.4198188,
-0.4446899,
0.0... |
Heterotopic free skeletal muscle autotransplantation with utilization of a long nerve graft and microsurgical techniques: a study in the primate. | In six monkeys the lateral head of the gastrocnemius muscle was transplanted to the dorsum of the forearm after removal of the extensor muscles to the fingers. Microsurgical techniques were used to anastomose the artery and vein of the transplant to vessels in the forearm, and a 12 cm sural nerve graft was used to conn... | 106,084 | [
0.005286063,
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0.126118,
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0.05409396,
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-0.006528412,
-0.05934382,
0.2225455,
0.08716915... |
Fetal heart rate during a maternal grand mal epileptic seizure. | Although maternal ingestion of antiepileptic drugs is strongly suspected of causing congenital defects, particularly oral clefts, the effect of epilepsy itself or a combined effect of drug intake and epilepsy have not been excluded as etiological factors. Very little is known about fetal oxygenation during a maternal g... | 106,102 | [
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0.3848498,
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0.006316483,
0.2391779,
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Blood chemical and haematological changes in diarrhoeic baboons (Papio ursinus). | Blood was collected for blood chemical and haematological determinations from untreated surviving and non-surviving diarrhoeic baboons. The significance of changes in blood chemical and haematological values is discussed and the importance of supportive treatment is emphasized. | 106,115 | [
0.07769816,
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-0.424256,
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0.1116265,
0.14,
-0.02807293,
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0.2038707,
0.3437137,
-0.0264715,
0.05461118,
-0.0696503,
0.02544772,
-0.2092204,
0.1201606,
0.03507588,
0.3805537,
-0.09908263,
0.0638257,
-0.345656,
-0.2... |
Remote afterloading endocurie therapy for carcinoma of the cervix. | Since October 1975, 41 cancer patients were treated with a remote afterloading device using fractionated high dose-rate intracavitary radiation. Nineteen of these 41 patients were treated for carcinoma of the cervix. Remote afterloading high dose-rate fractionated intracavitary radiation was given in combination with e... | 106,133 | [
-0.2048994,
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0.01722148,
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0.4097092,
0.1216019,
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0.... |
[Experimental verification of the results of the mathematical modeling of the process of formation of alpha-amylase-nonproductive mutants of Bacillus subtilis under continous cultivation]. | When Bacillus subtilis produces alpha-amylase in the course of continuous cultivation, it is difficult to maintain the activity at a constant level. This may be due to the formation of nonproductive mutants. Individual cells in the population have been analysed in the course of the continuous process. The composition o... | 106,225 | [
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0.2242939,
0.601932,
0.1464657,
0.03415095,
0... |
[Problems of alloplastic joint replacement (author's transl)]. | Nowadays artificial joint substitution can be assessed as a definite part of orthopedic surgery. The good primary results must not obscure the fact that in spite of great progress in the field of endoprosthesis, numerous problems must still be considered unsolved. Most important are the problems associated with anchori... | 106,248 | [
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0.07901588,
-... |
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. | A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin gamma1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing studies showed that the three protein domains and the hinge region are encoded in separate DNA segments. | 106,304 | [
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[Catheterisation of the internal jugular vein for parenteral nutrition (author's transl)]. | The technique consists of surgical exposure of the vein, its isolation by two threads and the introduction of a soft prethoracic exit. This technique avoids the complications inherent in any blind puncture of a large vessel. By virtue of the type of catheter (soft silicone) and the long subcutaneous course. It may be l... | 106,363 | [
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0.01297343,
0.07563581,
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0.155977... |
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. | We have isolated a myeloma genomic DNA clone containing the variable and constant regions of a mouse alpha chain. Restriction enzyme analyses and electron microscopic R loop mapping have demonstrated that the variable region is separated from the constant region by 6.8 kilobases of intervening DNA. In addition, two int... | 106,394 | [
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Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond. | Reduction of the single disulfide bond between heavy chains in the hinge region of rabbit IgG antibody causes destabilization of the CH2 region of the molecule. Our studies indicate that reduced antibody molecules undergo a large change in quaternary structure in the CH2 region upon aggregation with a small bivalent ha... | 106,398 | [
-0.02332841,
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0.2153445,
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0.09931532,
-0.0386112... |
Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera. | We present evidence for a role of I-A subregion-encoded determinants in syngeneic tumor immunity. In animals rendered immune to the S1509a fibrosarcoma, daily treatment with microliter quantities of antisera directed against Kk and I-Ak determinants expressed on lymphoid cells of host origin decreased the capacity for ... | 106,399 | [
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0.2124241,
0.1517556,
0.01571391,
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0.1... |
Complications of total abdominal and spleen irradiation in patients with lymphomas. | Fifty patients with non-Hodgkin's lymphoma were treated with total abdominal irradiation to a dose of 3000 rad by anterior and posterior fields treated the same day. Fourteen patients developed complications, four with intestinal obstruction due to stenosis and three with total or partial intestinal irradiation damage.... | 106,446 | [
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0.3155691,
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0.4563679,
0.02317899,
... |
The VkVI subgroup of rabbit light chains: complete amino acid sequence of a third variable region (K29-213). | The amino acid sequence of the variable region of a rabbit anti-streptococcal A-variant antibody light chain was determined. By using a combination of different cleavage methods, the sequence was established. Large peptides were sequenced in an extensively modified Beckman sequentor. Light chain K29-213 belongs to a ra... | 106,464 | [
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0.283... |
Carcinoma in diverticulum of female urethra. | A case of female urethral diverticulum is reported by the authors. It is a rare disease and about 31 cases have previously been described. An analysis is made in relation to the diverticulum of the urethra and to female urethral carcinoma. Emphasis is given on the semiology and the recently acquired diagnostic procedur... | 106,501 | [
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0.3633771,
0.1304356,
-0.068009... |
[Role of metal ions in the catalytic activity of Aspergillus oryzae aminopeptidase]. | The paper deals with the role of metals in the catalytic action of Asp. oryzae aminopeptidase. Cobalt ions are more specific activators than Mn2+ and Mn2+ and evoke its maximal activity. Sinergic activation of Co2+ in combination with Mn2+ and Mg2+ was not found in contrast to some aminopeptidases of animal origin. Act... | 106,499 | [
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0.5049517,
0.481113,
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0.... |
[Determination of aflatoxins in cheeses]. | To investigate cheeses for the presence of aflatoxins we chose the very sensitive method of Tuinstra and Bronsgeest (1975) used for the determination of aflatoxin M1 in milk. The method was slightly modified and the presence of aflatoxins was determined in 54 samples of different cheeses. Aflatoxin M1 was found out in ... | 106,514 | [
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0.1918855,
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-0... |
[Epidemiological evaluation of the serological grouping of meningococci]. | Use of the precipitation and hemagglutination inhibition tests to determine the serological group of 114 meningococcus strains which cannot be grouped by agglutination slide permitted to establish the serological group of 56% of the strains, this pointing to the greater diagnostic value of these tests. Nevertheless, 70... | 106,606 | [
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0.03149109,
0.08542289,
0.02283818,
0.1706668,
0.5131902,
-0.02696628,
-0.03661... |
Interferon therapy in multiple myeloma. | A woman with multiple myeloma relapsed after 6 years of satisfactory tumor control with melphalan therapy. When progression then occurred, she was given exogenous human leukocyte interferon, 3 x 10(6) reference units twice daily i.m., as the sole therapy. Side-effects of the interferon therapy consisted of fever reacti... | 106,625 | [
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0.3415546,
0.3484971,
-0.130613,
-0.03590... |
Balanced intraintestinal nutrition. A preparation for intraintestinal no-residue nutrition. | The investigations were carried out on dogs and male Wistar rats using the method of isolated intestinal loops. The absorption of nitrogen from a preparation was studied. The protein component of the preparation was an enzymatic hydrolysate of whey proteins, milk proteins, casein and a 7% bovine blood hydrolysate manuf... | 106,624 | [
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0.3722253,
0.0881538... |
Sequential CT observations of irradiated intracranial germinomas. | Computed tomography (CT) has improved the accuracy of preoperative diagnosis of intracranial tumors. CT findings of germinoma are a mass of isodensity or of slightly increased density with significant, homogeneous enhancement after intravenous contrast injection. These findings are characteristic but not pathognomonic,... | 106,637 | [
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0.05397148,
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0.08323227,
-0.05495525,
0.09677646... |
Radiography of glycogen storage diseases. | Sixty-three patients with glycogen storage disease were evaluated. Findings on plain film examinations, excretory urography, barium gastrointestinal studies, ultrasonography, and angiography were categorized by type of glycogen storage disease. In type I findings include hepatomegaly with hepatic dysfunction, renomegal... | 106,640 | [
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0... |
Radiology of the pterygoid plates and pterygopalatine fossa. | The pterygopalatine fossa is a major distribution center for the parasympathetic innervation and vascular supply of deep facial structures. Through eight bony canals or foramina, this fossa communicates with the nasal and oral cavities, infra-temporal fossa, orbit, pharynx, and middle cranial fossa. Therefore this impo... | 106,641 | [
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0.3028065,
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0.2444693,
0.1922115,
-0.120087... |
Radiographic features of eosinophilic gastroenteritis (allergic gastroenteropathy) of childhood. | The child with eosinophilic gastroenteritis has failure to thrive, a history of allergy or asthma, iron deficiency anemia, and peripheral eosinophilia. This type of eosinophilic gastroenteritis has earned the designation "allergic gastroenteropathy." Pathologic change in the gastric antrum of six children with this dis... | 106,689 | [
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Ultrasound of gallbladder wall thickening and its relation to cholecystitis. | A prospective ultrasound study of gallbladder wall thickness in patients with suspected gallbladder disease was performed over a 9 month period. Gallbladder walls thicker than 3 mm in fasting patients whose gallbladders were wider than 2 cm were considered abnormal. Gallstones were documented by ultrasound in 62 patien... | 106,690 | [
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0.2778506,
0.05487191,
-0.005044276... |
Esophageal diverticula. | Congenital, neuromuscular and motor abnormalities of the pharynx, esophagus and diaphragm, coupled with intra- and extraluminal factors, play roles in the pathogenesis of esophageal diverticula. Principal presenting symptoms are regurgitation, obstruction, aspiration, pneumonitis and esophagitis. Cineradiography and ma... | 106,716 | [
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0.3212452,
0.1045569,
-0.1001696... |
Evaluation of a gonococcal serologic test. | The fluorescent gonorrhea test--heated (FGT-H), an indirect immunofluorescent method for detecting the presence of antigonococcal antibodies in serum, was evaluated in 1,000 women referred to a private clinic for the termination of pregnancy, 202 women treated at a municipal venereal disease clinic, and six women hospi... | 106,719 | [
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0.2896388,
0.2964331,
0.41307,
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0.166060... |
Raised intracranial pressure: its management in Neisseria meningitidis meningoencephalitis. | Further reduction in morbidity and mortality from bacterial meningitis is unlikely to stem from innovations in antibiotic management. Emphasis must therefore be directed toward prevention, more rapid diagnosis, and improved therapy for maintaining the integrity of the CNS. Raised intracranial pressure is frequently ass... | 106,721 | [
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-0.03548123,
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-0.1254095,
0.1722311,... |
[Change in heart function in Duchênne de Boulogne myopathies at the severe progressive stage]. | Left ventricular function was studied in 15 patients with rapidly progressive Duchenne de Boulogne muscular dystrophy. Only one patient had a previous history of cardiac failure. All patients had typical electrocardiographical changes. Haemodynamic and angiographic investigation was performed in all patients. Three gro... | 106,797 | [
-0.5645612,
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0.1016863,
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... |
Implications of malnutrition in the surgical patient. | The substantial prevalence of malnutrition in the hospitalized patient population has only been recently recognized. Preoperative nutritional and immunological assessment was performed prospectively on admission in 64 consecutive surgical patients. Factors measured included weight loss, triceps skinfold, midarm muscle ... | 106,804 | [
-0.02501878,
-0.3039921,
-0.1648865,
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0.09859836,
0.04251386,
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0.4113949,
-0.09... |
[Various immunomorphological tests of cellular immunity in lymphogranulomatosis]. | Diffusion chambers were used to study the migration activity and blast transformation of lymphocytes in fragments of lymph nodes from untreated patients with lymphogranulomatosis of various histological variants and stages of the disease. Early in the disease, and particularly at its peak, a progressive decrease in the... | 106,807 | [
-0.07167547,
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-0.3153657,
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0.09728325,
0.4323338,
0.4927503,
-0.02958569,
0.18035... |
Epilepsy. | Epilepsy is a common disorder affecting approximately one in every two hundred people, from all walks of life, and presenting in addition to the seizure disorder itself, varying social, psychological and economic problems. A simple classification of epilepsy is described, and the concept of 'seizure threshold' introduc... | 106,817 | [
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-0.0298399,
0.05498322,
-0.05402127,
-0.2035013,
0.3095648,
0.02311409,
0.06188095,
-0.3897263,
0.1381537,
-0.1626... |
[Release of antigens into the culture medium by LS fibroblasts in culture]. | LS fibroblasts cultivated for 1 or more days in unsupplemented Eagle's MEM release antigens into the medium, without showing any evidence of lysis, but on the contrary continuing to proliferate. These antigens give up to three precipitation lines when tested by means of immunodiffusion and immunoelectrophoresis against... | 106,863 | [
-0.2586332,
-0.3717965,
0.1303926,
-0.01658264,
0.1515683,
-0.3342108,
-0.3806568,
0.1153236,
0.1099129,
-0.09581294,
-0.1239301,
0.2041402,
0.06100028,
0.01282009,
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-0.5218844,
-0.2797704,
-0.1646876,
0.5179499,
0.3567954,
-0.2933564,
-0.3067352,
... |
[Vascular thrombosis after catheterization of the umbilical artery]. | Two newborns with vascular thromboses due to catheterization of the umbilical artery are reported; one of them died and in the other one it was necessary to amputate the leg. Considerations are made on the predisposing factors for this complications, as well as the indications and precautions for this technic. | 106,862 | [
-0.1440724,
0.04595482,
-0.0730183,
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0.1459265,
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0.09380182,
0.3022461,
0.1922453,
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-0.4400414,
0.1232322,
-0.1951088,
-0.01049929,
0.355804,
-0.07148195,
0.07020624... |
Proton irradiation of malignant melanoma of the ciliary body. | This is our first case of malignant melanoma of the ciliary body treated with proton beam irradiation, a technique that we developed for irradiating choroidal melanomas. After 21 months of follow-up no growth of the tumour has been observed, and shrinkage of the tumour was noted on the follow-up photographs and by ultr... | 106,873 | [
-0.4340656,
-0.06347147,
-0.4030864,
0.1291394,
0.02120418,
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0.1337585,
0.2855006,
0.0952666,
0.1328781,
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0.05490916,
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0.2905287,
-0.01216592,
-0.1351087,
0.5838811,
-0.07183634,
0.1209207,
... |
Cell-free protein synthesis in lysates of Drosophila melanogaster cells. | A procedure is described for preparing cell-free protein synthesizing lysates from Drosophila melanogaster tissue culture cells and embryos. Preparation of translationally active lysates from tissue culture cells is dependent on the presence of rat liver supernatant during cell lysis to inhibit ribonuclease activity. A... | 106,888 | [
-0.0178778,
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-0.04493773,
0.1379002,
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0.09216616,
0.4001658,
0.1502357,
0.1484755,
0.2196753,
0.2424137,
0.1952537,
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0.2991752,
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-0.07083659,
-0.06222446,
0.2149343,
0.4587812,
0.0846429,
-0.3278656,
0.... |
Phase changes of cardiolipin vesicles mediated by divalent cations. | Small unilamellar vesicles were prepared from cardiolipin and produced the hexagonal II phase when dialyzed against CaCl2 or MgCl2. Upon removal of the cation by dialysis against EDTA large unilamellar vesicles were formed. The events of the transition from the lamellar to hexagonal phase and back to the lamellar phase... | 106,890 | [
-0.3651449,
0.2424875,
-0.5171,
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0.02539864,
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-0.2066065,
0.1152125,
0.1072548,
0.09321664,
0.09553273,
0.2810434,
-0.1049562,
0.2396398,
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-0.2158318,
0.01143114,
-0.1180543,
0.1236924,
0.003390727,
0.1909863,
0.1379676,
0.1... |
[Production of vitamin B 12 by a blue-green alga]. | In this study, we have been able to demonstrate the production and liberation of vitamin B12 (up to 16.5 pg/ml after 31 days of growth) by a blue green alga. Anabaena flos-aquae, in non-axenic and axenic cultures. This finding has a relevant ecological significance since it shows that, like bacteria, blue green algae m... | 106,945 | [
-0.336059,
-0.1844637,
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0.05637061,
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0.01172162,
-0.2202948,
-0.3635996,
-0.0820725,
0.4518125,
-0.1066345,
-0.04864484,
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-0.2113477,
-0.3781727,
0.3273757,
0.02940412,
0.09129098,
0.4277963,
0.3630233,
-0.2959896... |
Irradiation alone or in combination with surgery in stage IB and IIA carcinoma of the uterine cervix: A nonrandomized comparison. | This is a report of a nonrandomized comparison of treatment results of 244 patients with stage IB carcinoma of the uterine cervix treated by radiation alone and 92 treated with preoperative radiation and surgery and 77 patients with stage IIA treated by radiation alone and 24 treated with a combination of radiation and... | 106,953 | [
0.0100558,
-0.08710514,
-0.2793482,
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0.05145276,
-0.2881477,
0.09930134,
-0.2632087,
0.1972279,
0.1846841,
-0.1752315,
-0.1040118,
-0.1272263,
-0.1336315,
-0.3019678,
-0.3621435,
0.1973281,
0.1796474,
0.0186253,
0.3288865,
0.2831118,
0.383116,
-0.1407821,
0.3... |
Comparative randomized study of protected environment plus oral antibiotics versus oral antibiotics alone in neutropenic patients. | A series of 24 patients with severe neutropenia, most of whom had acute myeloblastic leukemia, were treated in an isolation unit with oral nonabsorbable antibiotics and were compared to 21 similar patients receiving oral antibiotics alone. The frequency of bacterial infections was lower in the patients receiving both i... | 106,963 | [
-0.06727824,
0.04612429,
0.1082996,
-0.0006518774,
-0.241883,
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-0.2513532,
-0.3300428,
0.04291058,
-0.2305426,
-0.001812277,
0.2158033,
0.08994974,
0.150967,
-0.1664919,
-0.3236476,
-0.1369607,
0.04955492,
-0.3573801,
0.09484007,
-0.06837778,
0.05357747,
0.1147... |
Production, purification, and properties of dextransucrase from Leuconostoc mesenteroides NRRL B-512F. | The production of dextransucrase from Leuconostoc mesenteroides NRRL B-512F was stimulated 2-fold by the addition of 0.005% of calcium chloride to the medium; levansucrase levels were unaffected. Dextransucrase was purified by concentration and dialysis of the culture supernatant with a Bio-Fiber 80 miniplant, and by t... | 106,966 | [
-0.06676668,
-0.1409346,
-0.2326889,
0.1468295,
0.1433884,
-0.1316574,
-0.2336337,
0.2275121,
-0.06206774,
0.2353716,
-0.1880229,
-0.291315,
0.2327859,
0.2269136,
-0.4724537,
0.01511984,
-0.1368961,
0.0667785,
-0.1192714,
0.3013214,
0.3598809,
0.37326,
-0.09047188,
0.35... |
[Evidence of a circadian sequence of photogonadsensitivity in the ferret]. | Using "skeleton" photoperiods with a primary photofraction of 3 hrs. 30 min. and secondary photofraction of 30 min. located at various intervals after the onset of darkness, the occurrence of a photoinducible phase in the androgenic function has been evidenced in the Ferret. This photo-inducible phase seems to be locat... | 106,984 | [
-0.02689858,
-0.1162738,
-0.04319238,
-0.2474571,
0.05828762,
-0.3614178,
-0.3850812,
-0.124228,
0.1758415,
-0.1706609,
0.1835725,
-0.1252671,
0.1714333,
-0.3052942,
-0.3501602,
-0.3125848,
-0.2483869,
0.2428929,
0.1292658,
0.05214779,
0.3299352,
0.1072476,
-0.1416785,
... |
Effects of nitroglycerin on echocardiographic measurements of left ventricular wall thickness and regional myocardial performance during acute coronary ischemia. | The effects of nitroglycerin on regional left ventricular performance, assessed by echocardiographic techniques, were investigated in anesthetized, open-chest dogs during acute myocardial ischemia. During transient occlusion of the left anterior descending coronary artery, there was end-diastolic thinning and marked re... | 106,986 | [
-0.1534868,
0.3469273,
-0.3817381,
-0.1830438,
0.05274043,
-0.236503,
0.2207035,
-0.4056213,
0.08279312,
-0.2008629,
0.088616,
-0.0856868,
-0.2628497,
0.03753947,
-0.1523912,
-0.02716816,
-0.479701,
0.347806,
-0.04696339,
0.04319543,
0.03888467,
-0.00020091,
0.04871649,
... |
[Long-lasting EEG abnormalities in alkylphosphat intoxication (author's transl)]. | In the reported case of a severe alkylphosphate poisoning the first EEG-observation at the twentieth day after intake showed marked abnormalities although there was a complete physical and humoral recovery. Progressive normalization of the EEG occured in the following six weeks. Psychopathological symptoms of a mild ap... | 107,015 | [
-0.2632463,
-0.1116304,
-0.2618607,
-0.2421252,
0.08876254,
-0.08437926,
-0.4725021,
0.04911155,
-0.09797783,
-0.08590189,
0.1811658,
0.2887939,
0.06505519,
0.2255241,
-0.2779965,
0.006303652,
-0.4174434,
0.2591009,
0.2385541,
0.4018574,
0.06771659,
0.08711074,
-0.0916685... |
Serum estradiol, testosterone and dihydrotestosterone in male monkeys treated with testosterone propionate. | Serum estradiol (E2), testosterone (T) and dihydrotestosterone (DHT) were measured in juvenile (pre-pubertal) male rhesus monkeys injected with either 8 mg or 80 mg of testosterone propionate (TP). After one week, the three steroids were elevated and remained essentially unchanged for the duration of the study. There w... | 107,019 | [
-0.01533281,
-0.002111023,
-0.255035,
-0.2892156,
-0.1845947,
-0.3347928,
-0.1709497,
0.2249911,
-0.1869946,
0.1512786,
0.1950765,
0.2218338,
0.0499655,
0.06702274,
-0.6248636,
-0.3904624,
-0.03055751,
0.1024188,
0.03967897,
0.213589,
0.1385444,
0.226432,
-0.05605857,
-... |
Effect of active and passive antibacterial immunization on skin allograft survival in rabbits. | The effect of active and passive antibacterial immunization on transplantation immunity was investigated in rabbits. Immunization with dead bacterial vaccines prepared from E. coli, Proteus mirabilis and Pseudmonas aeruginosa had no effect on skin allograft survival, whereas immunization with vaccines prepared from str... | 107,050 | [
-0.1565113,
0.02222444,
-0.3908993,
-0.07162424,
-0.01611313,
-0.2639251,
-0.2788908,
0.194013,
-0.1736125,
0.03669819,
0.1238722,
0.117928,
-0.1054284,
0.163039,
-0.1679048,
-0.05231442,
-0.1315497,
0.1153367,
-0.1296553,
0.2046207,
0.5193932,
0.3985844,
0.1283708,
-0.... |
[Use of maltose and a mixture of maltose, fructose and xylitol in parenteral feeding]. | Maltose or maltose in combination with fructose and xylitol was administered intravenously to eight healthy male subjects. Constant maltose levels could not be attained in the blood at an infusion rate of 0.125 g maltose/kg body-weight and hour. Maximal concentrations of maltose were found at the end of the infusion pe... | 107,124 | [
-0.1098246,
-0.1889337,
-0.1991572,
0.155646,
0.3044291,
-0.2623067,
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0.1002181,
-0.4157425,
-0.1487338,
0.1921889,
-0.2986422,
-0.09413656,
-0.05459299,
-0.6161184,
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-0.5592404,
0.2173197,
-0.1146822,
0.03705278,
0.4021655,
0.1761314,
0.1043965,
-... |
Oral bony lesion in a patient with medical history of hyperparathyroidism. | Primary hyperparathyroidism is an uncommon disease in which the amount of parathyroid hormone circulating in the bloodstream is increased. Therefore, bony changes are often found in the prolonged or severe cases of hyperparathyroidism. This study describes and discusses the relationship between cystical radiolucent les... | 107,137 | [
-0.3049805,
-0.3169978,
0.09107864,
-0.2119843,
-0.1585084,
-0.3822024,
-0.2146108,
0.07750323,
0.2065177,
0.01565193,
0.2048876,
0.270672,
-0.2775759,
-0.1733624,
-0.4094896,
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-0.3355022,
0.1389484,
0.3899831,
0.02480835,
0.09060632,
0.2139275,
-0.2768789,
0.... |
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