title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A light microscopic study of the effects of testicular hyaluronidase on the outflow system of a baboon (Papio cynocephalus). | An attempt was made to investigate the effects of hyaluronidase on the morphology of the baboon outflow system. The eyes of six adult baboons provided the material for this histological study. For each animal the IOP in both eyes was maintained at 18 mm Hg, and 150 IU of testicular hyaluronidase were introduced into on... | 107,142 | [
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Purine nucleoside phosphorylase cleaves the C--O bond of ribose 1-phosphate. Evidence from the 18O shift in 31P NMR. | An equilibrium mixture of highly enriched [18(O)]Pi (represents the mixture of [[18(O)4]Pi, [[18(O)3]Pi, [18(O)2]Pi as represented in the figures, unless otherwise specified), alpha-D-ribose 1-[16(O)]phosphate, and hypoxanthine plus inosine was equilibrated with calf spleen purine-nucleoside phosphorylase (EC 2.4.2.1).... | 107,157 | [
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Microtubules and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Cultured C-6 glial cells were utilized to evaluate the effect of antimicrotubular drugs on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and cholesterol synthesis. Colchicine, Colcemid, and vinblastine (1.0 muM) caused a marked reduction in HMG-CoA reductase activity and, as a consequence, the rate of chole... | 107,160 | [
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Biological properties of antibodies against rat adipocyte intrinsic membrane proteins. Dependence on multivalency for insulin-like activity. | Antisera from rabbits injected with rat adipocyte plasma membranes or intrinsic proteins from such membranes, obtained by a dimethylmaleic anhydride extraction step, mimicked the action of insulin on both glucose transport and lipolysis in intact adipocytes. Biological activity in both types of antisera was mediated by... | 107,169 | [
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Thyrotropin suppression by 3,5-dimethyl-3'-isopropyl-L-thyronine in man. | The thyromimetic activity of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT), a nonhalogenated thyroid analog, was studied in adult men using suppression of TRH-induced TSH release to assess this activity. In nine men, aged 30-58 yr, the TSH increment after 500 microgram TRH iv was compared to the TSH response to TRH 24 ... | 107,177 | [
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Halophilic, lactose-positive Vibrio in a case of fatal septicemia. | A halophilic Vibrio species was isolated from blood cultures from a 59-year-old male with enteritis. The strain differed from Vibrio parahaemolyticus and Vibrio alginolyticus by its ability to ferment lactose, its production of beta-galactosidase, and its lower NaCl tolerance. A report of this infection and a descripti... | 107,189 | [
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Connections of areas 3b and 1 of the parietal somatosensory strip with the ventroposterior nucleus in the owl monkey (Aotus trivirgatus). | Anatomical tracers were injected into electrophysiologically defined sites in somatosensory cortical Area 3b (SI proper) and Area I (posterior cutaneous field) of owl monkeys after these cortical subdivisions had been extensively explored in microelectrode mapping experiments. These mapping experiments revealed that bo... | 107,204 | [
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Auditing the process of care in a new geriatric unit. | To assess whether the objectives of a new Extended Care Unit were reflected in the care of the patients and in the outcome of that care, an audit of the patients' records was performed. The audit sample involved 101 geriatric patients who had been admitted to the Unit for rehabilitation therapy, and then discharged. Th... | 107,211 | [
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Hyperthyroidism in the elderly. | In 65 elderly hyperthyroid patients (age range 50-78 years), sex differences, signs and symptoms and thyroid function were studied and the data were compared with those on 48 young hyperthyroid patients (age range 20-29 years). The incidence of hyperthyroidism was 3.5 times higher in females than in males among the you... | 107,212 | [
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Effectiveness of hypertension screening in an urban optometric clinic. | 461 randomly selected eyecare patients were screened for systemic hypertension at the clinic of the University Optometric Center, State College of Optometry, State University of New York. The results of this survey showed 52 screening failures, 30 of whom had previously been identified as having hypertension. The study... | 107,214 | [
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Ultrastructural localisation of lipopolysaccharide-binding sites with peroxidase-conjugated lipopolysaccharides. | The localisation of lipopolysaccharide-binding sites on erythrocytes with peroxidase-coupled LPS is described. LPS was isolated from Fusobacterium nucleatum (Fus MC-8) by phenol-water extraction. The LPS was coupled to horseradish peroxidase by the two-step method of Avrameas and Ternynck (1971). The biological and ser... | 107,240 | [
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Radioimmunoassay of hepatitis B e-antigen (HBeAg): identification of HBeAg not associated with immunoglobulins. | A radioimmunoassay for hepatitis B e-antigen (HBeAg) is described. Polystyrene beads coated with IgG prepared from a human serum containing antibodies to HBeAg (anti-HBe) and anti-HBe IgG labelled with 125I-p-hydroxyphenylpropionic acid N-hydroxysuccinimide ester were used in the test. The radioimmunoassay was approxim... | 107,272 | [
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Two cases of mucopolysaccharidosis type III (Sanfilippo). A biochemical study. | The mucopolysaccharide and lipid composition of human nervous tissue and viscera from one case of Sanfilippo disease type A and one case of Sanfilippo disease type C, were investigated. In the brain a moderate increase of acid glycosaminoglycans occurred. This phenomenon was much more pronounced in the viscera, especia... | 107,278 | [
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Photoreceptor coupling in retina of the toad, Bufo marinus. I. Anatomy. | 1. Red rod photoreceptors in the toad retina, which are known to be physiologically coupled, were examined for interreceptor contacts. 2. A dense network of large gap junctions was found between the inner segments of red rods, this being the only specialized site of contact that was observed between rods. Each red rod ... | 107,280 | [
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The effects of ischemia on long-tract neural conduction in the spinal cord. | In this experiment, the effects of ischemia on neural conduction in the monkey spinal cord were studied. In six monkeys generalized ischemia of the spinal cord was created by bleeding the animals to a hypotensive level below the lower limits of autoregulation in the spinal cord. The progressive development of spinal co... | 107,290 | [
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Tables to estimate total binding capacity of thyroxine-binding globulin from the in vitro thyroid function tests. | Equations for an estimate of the total binding capacity of serum thyroxine-binding globulin (TBG-TC) were developed relating this parameter to serum thyroxine concentration (T4) and in vitro uptake (T3U). This extimate demonstrated a highly significant, positive correlation with TBG-TC as measured by electrophoresis in... | 107,292 | [
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Percutaneous nitroglycerin absorption in rats. | Percutaneous nitroglycerin absorption was studied in shaved rats by monitoring unchanged plasma drug concentrations for up to 4 hr. Drug absorption from the neat liquid state or from an alcoholic solution was considerably poorer than that from a commercial ointment. This observation was unanticipated since the driving ... | 107,313 | [
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Vaccinia virus replication. I. Requirement for the host-cell nucleus. | Using cytochalasin B-induced enucleation techniques, we examined the ability of vaccinia virus to replicate in the absence of the host-cell nucleus in several mammalian cell lines. It was found that virus-infected enucleated cells (cytoplasts) prepared from BSC-40, CVC, and L cells were incapable of producing infectiou... | 107,327 | [
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A novel Tetrahymena sp. with unusual membrane lipid composition, with special reference to iso fatty acyl chains. | A novel Tetrahymena sp. is similar in appearance to four classical strains (WH-14, GL, W, NT-1) of T. pyriformis except for a larger width. The phospholipid and acyl chain compositions of membranes of this novel species are significantly different from those of other strains. The Tetrahymena sp. has a much higher conte... | 107,352 | [
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[Suicide in schoolchildren (author's transl)]. | Suicides by 66 children aged from 9 to 16 years (47 boys, 19 girls) and attempted suicides by 22 children (8 boys, 14 girls) are reported. Poisoning by mouth and hanging are the most common forms of suicide. The provocation for suicide may be trifling whereas the motivation, not always explicable even in children, is a... | 107,437 | [
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Immunologic functions and in vitro activation of cultured macrophage tumor lines. | Five murine monocyte of macrophage tumor lines adapted to culture were characterized for differentiated properties. They ingested zymosan and latex beads, bore receptors for immunoglobulin and complement, synthesized lysozyme (most of which was secreted), and produced granulocyte colony-stimulating activity, either spo... | 107,454 | [
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Association of tritium-labelled estradiol, progesterone and 17 alpha-hydroxyprogesterone with the proteins of the serum and cerebrospinal fluid in the rhesus monkey. | The electrophoretic profiles of the proteins in the serum and cerebrospinal fluid (CSF) of the rhesus monkey were studied by polyacrylamide gel electrophoresis. The association of tritium labelled estradiol (3H-E), progesterone (3H-P) and 17 alpha-hydroxyprogesterone (3H-17OHP) with these proteins was studied under in ... | 107,466 | [
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Ultrastructural alterations in experimental lingual leukoplakia and carcinoma. | Epidermoid carcinomas, preceded by dysplastic leukoplakic lesions, were produced on the right lateral borders of the tongues of Syrian hamsters by the application, three times per week, of DMBA in acetone after the area had been scratched with a root canal broach. Animals were killed at 12 to 13 weeks and 15 to 16 week... | 107,501 | [
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[Anabolic effects of steroid hormones in rabbits (author's transl)]. | The anabolic effect of steroid hormones was investigated in rabbits by measuring the skeletal accumulation rate of 85Sr following the continuous administration of estrogens, androgens and corticosteroids over a period of eight weeks. Androgenic hormones did not influence the accumulation rate of 85Sr, whereas following... | 107,513 | [
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Fat-induced jejunal inhibition of gastric acid secretion and release of pancreatic glucagon, enteroglucagon, gastric inhibitory polypeptide, and vasoactive intestinal polypeptide in man. | The effect of intrajejunal (i.j.) infusion of fat on meal-stimulated gastric acid secretion and release of pancreatic glucagon (PG), enteroglucagon (EG), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) was studied in seven healthy volunteers. I.j. fat markedly inhibited meal-stimulated... | 107,575 | [
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Enteric infections in Singapore with special reference to typhoid. | A review of the epidemiological features of the more important enteric infections in Singapore was given. Enteric fevers (typhoid and paratyphoid), Salmonella gastroenteritis and Shigellosis remained endemic at a rather constant level in spite of vast improvement in environmental sanitation, but amoebic dysentery showe... | 107,597 | [
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A vest for ambulatory patients receiving hyperalimentation. | There have been no significant complications related to the use of this ambulatory hyperalimentation vest. The potential positive impact that increased use of this vest at home might have upon hospital stay and cost containment is obvious. It is further anticipated that, as advances are made in the technology of plasti... | 107,602 | [
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[Action of secretin on the gastric secretion induced by food stimuli, pentagastrin, histamine and the parenteral administration of casein hydrolysate]. | In tests on dogs with innervated and vagus denervated miniature stomaches and gastric fistula the action of secretin on the gastric secretion provoked by food stimulants-pentagastrin, histamine and parenteral introduction of casein hydrolysate was studied. Experiments showed the secretin to produce an inhibiting action... | 107,652 | [
-0.1242785,
-0.3830618,
-0.04409252,
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0.05950234,
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0.09143431,
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0.14100... |
Anatomical basis of variability in injuries of the medial malleolus and the deltoid ligament. I. Anatomical studies. | An anatomical study of the medial malleolus and the deltoid ligament of the ankle on fresh and formalin preserved legs of cadavera and amputation specimens has been carried out. The anterior and posterior colliculi, and the intercollicular groove of the medial malleolus were described. The deltoid ligament was found to... | 107,719 | [
-0.01905942,
0.08368699,
0.01380181,
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0.1144643,
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0.2543561,
0.03401031,
0.1383479,
0.3255808,
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0.01634254,
-0.1692389,
0.1981342,
0.2377293,
-0.008782684,
-0.2626381... |
Nonvisualized gallbladder by cholecystosonography. | To further define the significance of gallbladder nonvisualization by cholecystosonography, we studied follow-up data on 25 consecutive patients in whom the gallbladder could not be identified despite adequate fasting. In one patient, intravenous cholangiography demonstrated a large gallbladder but no gallstones. In th... | 107,735 | [
-0.09676889,
0.4389991,
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0.1985726,
0.01670448,
-0.3726028,
0.0979932,
0.1512111,
-0.06454963,
0.... |
Breast cancer missed by mammography. | Because a "negative" mammogram that is followed by a biopsy diagnostic of cancer is a matter of deep concern, a retrospective review was conducted of 48 such missed diagnoses at four Breast Cancer Detection Centers. The study group comprised 40,000 women participating in breast cancer screening examinations. From 3,271... | 107,737 | [
-0.1111868,
0.0721864,
0.00882934,
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0.1863475,
0.2238899,
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0.4872642,
0.08509806,
-0.1150874,
... |
Arterial impressions on the stomach. | The splenic artery frequently produces a contour defect on the posteromedial aspect of the stomach, particularly in elderly individuals. When the artery is tortuous or aneurysmal, the impression is prominent and may simulate a neoplasm. Similarly, the aorta can produce a gastric impression. Recognition of these impress... | 107,743 | [
-0.2332466,
0.07465679,
-0.4285432,
-0.420375,
0.3394881,
0.08575625,
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0.140223,
-0.07511141,
0.156415,
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-0.1018786,
-0.1503727,
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0.210979,
-0.04937842,
-0.1177448,
0.1610135,
0.09060404,
0.06787067,
0.... |
Visual compatibility of 30 additives with a parenteral nutrient solution. | The visual compatibility of 30 drug additives with total parenteral nutrient (TPN) solutions (4.25% amino acids, 25% dextrose injection) was studied. For each drug additive, three TPN solutions were mixed; two were stored for 22 hours at 4 C then allowed to equilibrate to room temperature for two hours. Two 25-ml sampl... | 107,797 | [
-0.01344634,
-0.248168,
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0.1053147,
0.1668616,
0.2671818,
0.3233056,
-0.1... |
Carbonic anhydrase-dependent bicarbonate reabsorption in the rat proximal tubule. | The extent to which bicarbonate reabsorption in the rat proximal convoluted tubule depends on carbonic anhydrase has been examined by in vivo microperfusion and the measurement of total CO2 concentration by microcalorimetry. Tubules were perfused with an ultrafiltrate-like solution at 13 nl/min, and volume reabsorptive... | 107,811 | [
-0.2568415,
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0.1484083,
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0.5494059,
0.2033371,
0.122967,
-0.003018601,
-0.01953374,
0.01489023... |
Stapedectomy. Postmortem findings. | Histological studies were made of 16 temporal bones of 13 subjects who had stapedectomy operations. Photographs of the prostheses in situ are a special feature of the studies. It was found that prostheses which overlap the margins of the oval window cause incomplete closure of the air-bone gaps. Fibrous adhesions were ... | 107,843 | [
-0.1967025,
0.2139371,
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-0.1632408,
-0.06085621,
-0.1821016,
0.2988986,
-0.08820163,
-0.05012555... |
Prognosis in Rh incompatibility. | The study was done on a material of 300 cases of Rh incompatibility. A relative correlation was found between fetal damage and newborn damage and the titer of antibodies. It was shown that production of anti-Rh antibodies was lower in feto-maternal ABO incompatibility. Coexistence of anti-Rh D antibody with other antib... | 107,914 | [
0.158704,
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0.0593151,
0.5046587,
0.00253969,
-0.07757908,
0... |
Indium 111 autologous tagged leukocytes in the diagnosis of intraperitoneal sepsis. | We report the results of a new test, indium oxine in 111 scanning, in the diagnosis of postoperative infection. Indium 111 was used to label autologous polymorphonuclear leukocytes, which when reinjected migrate to sites of infection, inflammation, or both. Standard scintigraphy localizes the labeled inflammatory cells... | 107,925 | [
-0.1245234,
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0.1358981,
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0.04544055,
0.1812217,
0.1516765,
-0.0295885... |
The application of immobilized enzymes in an artificial liver support system. | A novel method of extracorporeal support for fulminant liver failure is reported whereby the most important detoxification processes of the liver are reproduced in an enzyme reactor. Most of the endogenous toxins involved in hepatic coma can be deactivated directly by conjugation with a hydrophilic residue such as gluc... | 107,930 | [
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0.06110455,
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0.1792788,
0.1596479,
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0.08133202,
0.3508821,
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0.147278,
0.03528561,
0.1259215,
0.01414938,
-0.06962487,
-0.2878262... |
Impedance audiometry in the squirrel monkey. Effect of transection of crossed olivocochlear bundle. | Acoustic reflex thresholds in squirrel monkeys did not show any statistically significant change following midline section of the crossed olivocochlear bundle. Lack of agreement with the results reported by Borg in rabbits is most probably due to the species difference. | 107,934 | [
0.3082237,
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0.3114018,
... |
Purification and some physicochemical properties of staphylococcal enterotoxin D. | A method was developed for the isolation of staphylococcal enterotoxin D in highly purified form from cultures of Staphylococcus aureus strain 1151m. The method involves removal of the toxin from the culture supernatant fluid with the ion-exchange resin CG-50 followed by chromatography on carboxymethylcellulose (twice)... | 107,962 | [
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0.01443402,
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0.2280217,
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0.119293,
0.1053071,
0.1583358,
0.2242098,
-0.02681569,
... |
Isolation of Euglena gracilis chloroplast 5S ribosomal RNA and mapping the 5S rRNA gene on chloroplast DNA. | Ribosomal RNA (5S) from Euglena gracilis chloroplasts was isolated by preparative electrophoresis, labeled in vitro with 125I, and hybridized to restriction nuclease fragments from chloroplast DNA or cloned chloroplast DNA segments. Euglena chloroplast 5S rRNA is encoded in the chloroplast genome. The coding region of ... | 107,968 | [
-0.09786227,
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0.02439313,
... |
Effects of tetracyclines on aldosterone- and insulin-mediated Na+ transport in the toad urinary bladder. | The effect of oxytetracycline and demethylchlortetracycline on aldosterone- and insulin-mediated Na+ transport (short-circuit current) were examined in toad urinary bladders mounted in modified Ussing chambers. Oxytetracycline had little or no effect on either basal or aldosterone-mediated Na+ transport. In contrast, d... | 107,969 | [
-0.0603665,
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0.03892315,
-0.2170973,
0.1348439,
... |
Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain. | As part of an investigation of neuropeptide inactivation mechanisms, we have resolved an enzymatic activity in bovine brain which catalyzes the deamidation of thyrotropin releasing hormone (TRH) and the hydrolysis of the Pro9--Gly10--NH2 bond of luteinizing hormone releasing hormone (LH-RH) from a second LH-RH degradin... | 107,998 | [
-0.1514413,
-0.1223233,
-0.1167878,
0.1327685,
0.07975919,
-0.3728032,
-0.05596744,
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0.2277892,
0.2040907,
-0.001916943,
0.4272901,
-0.0237654... |
[Retrograde inhibitory effect of continuous reinstillation of digestive juice in temporary artificial and pathological enterostomies on the secretory digestive flow]. | The reinstillation of the digestive juice in the lower end of an enterostomy has a retrograde inhibitory effect on the upper digestive secretions (average inhibition of 30,2%) particularly on the intestinal juice during the digestive syndromes associated with one or several interruptions of the continuity of the bovel.... | 108,018 | [
-0.005333529,
-0.3847593,
0.0008842495,
0.002620905,
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0.0833364,
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-0.060438,
-0.0868132,
0.1400276,
-0.03663907,
0.2... |
[Lipid thesaurismosis rheumatism. Arthropathies in alpha galactosidase A deficiency (Fabry's disease). Ultrastructural study of the synovial membrane demonstrating microcrystals in the mitochondria of synoviocytes]. | Articular manifestations may be the onset of genetic alpha galactosidase deficiency (Fabry's disease). Ultrastructural study shows typical osmiophilic lamellar inclusions of trihexosylceramides in synoviocytes, capillaries and adipocytes. Furthermore microcrystals identical to those seen in Gaucher's disease and type I... | 108,031 | [
-0.2075005,
-0.07299156,
0.2239357,
0.3118237,
0.03152648,
-0.1567061,
-0.2905994,
0.05869837,
-0.2760078,
0.1681186,
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-0.2903249,
-0.1778382,
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0.2176947,
0.2387577,
0.001348991,
-0.1066049,
... |
Biochemical and clinical effects of ethane-1-hydroxy-1,1-diphosphonate in calcium nephrolithiasis. | 1. The short- and longer-term effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP), an inhibitor of crystal growth and potential preventive agent against urinary tract stones in man, have been studied. 2. Measurement of urinary excretion of EHDP was used to define the best dosage regimen. When 4.4 mmol of EHDP mmol of ... | 108,043 | [
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0.1186003,
-0.2460467,
-0.2159198,
-0.1838219,
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-0.5524721,
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-0.04140707,
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0.2137454,
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0.3290511,
0.1866607,
0.3061344,
-0.2331702,
... |
Evoked potential studies in petit mal epilepsy. Visual information processing in relation to spike and wave discharges. | The evoked potential has been useful in studying characteristics of the epileptic nervous system. To investigate whether an alteration in sensory processing is possibly related to behavioral unresponsiveness observed to precede spike and wave bursts, average visual evoked potentials (VEPs) were studied during a 4.0 sec... | 108,074 | [
-0.262723,
-0.1470635,
-0.4837674,
-0.441381,
0.02778106,
-0.6596256,
-0.1052453,
-0.3588546,
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-0.02660285,
0.1043663,
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-0.1323939,
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-0.3128295,
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0.1233209,
-0.04677355,
-0.2126542,
0.1832933,
0.07067841,... |
Involvement of the cerebellum in the initiation of fast ballistic movement in the monkey. | Monkeys were trained to perform a fast ballistic flexion or extension of the elbow in response to a sound cue. The reaction time was about 250 msec in the normal monkey and remained so after deafferentation of the operant arm. In a cerebellectomized animal, the reaction time was consistently longer, being, on the avera... | 108,081 | [
-0.2054742,
0.1553984,
-0.3418732,
-0.2235045,
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-0.4899081,
-0.001876104,
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-0.04160183,
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0.1810177,
0.210802,
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-0.5280898,
-0.1434512,
0.6276181,
-0.07139567,
0.2850233,
... |
Cortex, basal ganglia and cerebellum in motor control. | For voluntary movement, function generators are necessary that are located in the brain-stem, cerebellum and basal ganglia. Following lesions of these generators, voluntary movements are impaired while stimulus-dependent movements are still possible. This discussion also applies to speech production. The motor function... | 108,082 | [
-0.1857768,
0.04010958,
-0.1003366,
-0.2274068,
0.2025492,
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0.2249786,
-0.03711364,
0.02623866,... |
Serologic distinction between the rabbit kappa L chain allotype b4 and an allele b4. | Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detecte... | 108,110 | [
0.2059707,
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0.1274941,
0.1946184,
0.2213121,
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0.1... |
Effects of increasing Mg++ ion concentration on the PKU monitoring assay. | Inaccuracies in a commonly used bacterial inhibition assay for blood phenylalanine levels arise when the Mg++ ion concentration in the assay medium is increased. This has practical implications in the diagnosis and management of phenylketonuria. | 108,130 | [
-0.1232058,
-0.1480747,
-0.2277538,
-0.1038981,
0.06828485,
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0.09261011,
-0.04433899,
0.1747908,
0.05... |
Effect of selective proximal vagotomy on food-stimulated gastric acid secretion and gastrin release in patients with duodenal ulcer. | We studied effects of selective proximal vagotomy on food-stimulated acid secretion and gastrin release in 7 duodenal ulcer patients. Food-stimulated acid secretion was evaluated by sham feeding patients and by infusing food directly into their stomachs. Vagotomy reduced sham feeding-stimulated acid secretion from 28.2... | 108,176 | [
-0.06757244,
-0.3232402,
-0.4598101,
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-0.4373218,
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-0.4522684,
0.07783519,
-0.3344145,
0.02058027,
0.09384968,
0.1314094,
0.0914579... |
HLA AW19, B12 in immunoproliferative small intestinal disease. | A group of 21 patients with immunoproliferative small intestinal disease (IPSID), 10 with alpha heavy chain paraproteinaemia and 11 without it, were HLA typed. The results were compared with 35 disease controls and 120 normal controls. A significant increase of Aw19 and B12 antigens was noted among the patients compare... | 108,183 | [
-0.292765,
-0.4063419,
-0.01440263,
-0.4660454,
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0.03763896,
-0.1821107,
0.07299551,
0.2083608,
0.2760994,
-0.03266145,
-... |
Basic findings and current developments in sphingolipidoses. | Sphingolipidoses are caused by recessively inherited deficiencies of lysosomal hydrolases. The clinical backgrounds of and current biochemical and genetic approaches to the different forms and variants of gangliosidoses, trihexosylceramidosis (Fabry's disease), galactosylceramidosis (Krabbe's disease), sulfatidoses (me... | 108,196 | [
-0.1816881,
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-0.05375165,
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-0.09727409,
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0.02142829,
0.3532254,
-0.241084... |
Serum factors influencing antibody-directed cell-mediated cytotoxicity (ADCC) and their effects on the detection of immune complexes by inhibition of ADCC. | An imporved assay system, using inhibition of ADCC, for the detection of 0.6 microgram/ml. of aggregated IgG in medium is described. Under these conditions, normal human serum is extremely inhibitory, this effect being attributed mainly to the weak binding of monomeric IgG. Enhancement of ADCC by albumin was also obser... | 108,202 | [
0.1424095,
0.07329422,
0.02565413,
-0.1941399,
0.1615961,
-0.09732357,
0.05354608,
0.3517022,
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0.2747976,
0.08661539,
0.2013624,
-0.2298244,
0.08421627,
-0.4993751,
-0.001086764,
-0.1008981,
0.5471473,
0.3617224,
0.07578661,
-0.082768... |
Thrombocyte migration and the release of thrombocyte inhibitory factor (ThrIF) by T and B cells in the chicken. | The elaboration of various inhibitory factors by sensitized lymphocytes has been reported for both mammals and birds. Until recently, the ability of the B cell to elaborate these had been questioned by a number of investigators. We have demonstrated the release of a lymphocyte inhibitory factor from the avian thymus an... | 108,206 | [
-0.1955067,
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-... |
Comparative antibacterial activity of azlocillin, mezlocillin, carbenicillin and ticarcillin and relative stability to beta-lactamases of pseudomonas aeruginosa and klebsiella aerogenes. | The antibacterial activities of two ureidopenicillins, azlocillin and mezlocillin, were compared with those of the alpha-carboxypenicillins, carbenicillin and ticarcillin, against a large number of gram-positive and gram-negative bacteria. All four penicillins were active against a wide range of bacteria including Pseu... | 108,220 | [
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0.2919261,... |
[Outbreaks and sporadic cases of enteritis due to pseudomonas aeruginosa in premature babies and infants (author's transl)]. | In 1960 there were two outbreaks of mostly severe diarrhoea due to pseudomonas aeruginosa in the special nursery for premature infants and sick newborns of the Universitäts-Kinderklinik Münster/Westf. resp. Kinderklinik Offenbach/Main. In both cases a single strain of Ps. aeruginosa was isolated from patients with diar... | 108,223 | [
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0.2966102,
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0.1022859,
0.3524952,
0.0700708... |
Electron microscope study of the rod-to-coccus shape change in a temperature-sensitive rod- mutant of Bacillus subtilis. | The changes in cell morphology of Bacillus subtilis rodB during a temperature shift from 20 to 42 degrees C, in the absence of added anions, are described. At 20 degrees C the organisms grow as rods but gradually become spherical in shape when placed at 42 degrees C. The shape change is initiated by an increase in diam... | 108,248 | [
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... |
Detection of FP plasmids in hospital isolates of Pseudomonas aeruginosa. | A simple method of detection of FP plasmids with chromosome-mobilizing ability in Pseudomonas aeruginosa has been developed. | 108,252 | [
0.002476178,
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0.00... |
Characterization of a mutant form of ribosomal protein S1 from Escherichia coli. | An altered form of ribosomal protein S1 from a mutant of Escherichia coli has been isolated and characterized. The mutant protein (denoted m1-S1) has a molecular weight of 57,000 as shown by sodium dodecyl sulfate-gel electrophoresis and the same NH2-terminal sequence as wild type S1. Protein m1-S1 binds poly(U) in the... | 108,276 | [
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Ultrasonic visualization of Wirsung's duct: dream or reality? | Ultrasonic visualization of normal and pathological Wirsung's ducts has become quite common, especially with the newest gray scale units. Ductal images were studied in 17 cases of quiescent chronic pancreatitis. Duct dilatation could be identified in the majority | 108,297 | [
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Hepatitis Be antigen and antibody in hepatitis B surface antigen positive blood donors. | In a study of 105 asymptomatic HBsAg positive blood donors, 9 (8.6%) were found to have HBeAg, 38 (36.2%) anti-HBe, and the remaining 58 (55.2%) neither marker detectable by gel diffusion. There was no correlation between HBeAg/anti-HBe status and HBsAg sub-types, Glm allotypes, the presence of anti-Gm, red cell antibo... | 108,319 | [
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0.2739611,
0.1191887,
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0.18566... |
Aging in the rhesus monkey: effects on visual discrimination learning and reversal learning. | The behavior of aged rhesus monkeys (18 years and older) was compared to that of young monkeys (3 to 6 years old) to evaluate their relative abilities to learn a series of visual discrimination and discrimination reversal problems. Using a subject-paced, automated experimental procedure designed to optimize stimulus co... | 108,323 | [
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The effect of dietary sulfur-containing amino acids on the activity of drug-metabolizing enzymes in rat-liver microsomes. | Male Wistar rats were fed either a balanced diet whose protein source was a mixture of amino acids (diet 1), or a similar diet which differed only in having 48% less the quantity of the sulfur-containing amino acids methionine and cystine (diet 2). The diets were given either continuously for 1 month or for 15 days aft... | 108,366 | [
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0.116529,
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0.3206385,
0.0351417,
... |
Advances in epithelial kinetics--an oral view. | There is growing evidence that the basal layer of stratified squamous epithelia consists of cells of differing proliferative capacities and behaviour. These can be classified as stem cells, transient amplifying cells and post-mitotic maturing cells, the most important of which appear to be the stem cells which may be p... | 108,372 | [
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0.1466562,
-0.0376710... |
Plasma naltrexone kinetics after intravenous bolus administration in dogs and monkeys. | This investigation generated data characterize a specific electron-capture GLC assay reported previously for naltrexone and applied the method to a determination of naltrexone pharmacokinetics. Extraction efficiencies are reported for the assay, and mass spectral evidence indicates that naltrexone forms a triester when... | 108,382 | [
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... |
Effect of N-trifluoroacetyl derivatives of amino acids and amino acid analogs on microbial antitumor screen. | Eighteen trifluoroacetyl derivatives of amino acids and of amino acid analogs were prepared and tested for growth-inhibitory activity using a Lactobacillus casei system as a prescreen for antitumor activity. Of the compounds tested, the trifluoroacetyl derivatives of o-, m-, and p-fluorophenylalanine and of beta-3-thie... | 108,385 | [
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0.2734282,
0.08385286,
0.07539168,
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... |
Effects of morphine, diazepam and chlorpromazine on discrimination of electric shock. | The effects of morphine, diazepam and chlorpromazine were examined on the discrimination of electric shock in squirrel monkeys. Two discrete responses measured discrimination of the presence or absence of shock at two different intensities, either at 0.35 mA or at an intensity determined to be close to each monkey's th... | 108,386 | [
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0.2099791,
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0.3705381,
0.1625151,
-0.2332233,
0.07713... |
Plasma cell dyscrasia. Analysis of 423 patients. | Present clinical and laboratory diagnostic criteria permit a more accurate diagnosis and closer follow-up of patients with plasma cell dyscrasias. A ten-year follow-up of a group of 423 patients showed that the indications for and the adjustment of treatment are more precise when these criteria are summarized into prof... | 108,408 | [
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... |
[Fundamental studies and clinical evaluation of PC-904 in urinary tract infection (author's transl)]. | Measurement of MICs of PC-904, CBPC and GM against 135 strains of Pseudomonas aeruginosa isolated from patients with urinary tract infections was performed. Susceptibility to PC-904 of Pseudomonas aeruginosa was found to be 3 approximately 7 times more sensitive than that to CBPC and as same as that to GM with inoculum... | 108,428 | [
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0.2039811,
0.1103519,
... |
Galvanized caging as a potential factor in the development of the "fading infant" or "white monkey" syndrome. | Four rhesus females and their infants were kept in galvanized enclosures, and three were kept in stainless steel caging. All four offspring in the galvanized enclosures developed achromotrichia, alopecia, and weakness that varied from modererate to severe while the three infants in stainless steel cages were clinically... | 108,464 | [
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A versatile primate cage for a multiple use facility. | A mobile-transport-squeeze cage for primates was constructed. The cage contained a clear plastic guillotine door, squeeze apparatus, ventilation holes and locking casters. The squeeze apparatus could be operated by one person. | 108,471 | [
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Role of physiologic autoantibody in the removal of senescent human red cells. | The mechanism by which mononuclear phagocytes distinguish mature "self" from senescent "self" was investigated. Evidence is presented indicating that human mononuclear phagocytes distinguish senescent RBC from mature RBC on the basis of selective Ig attachment to the membranes of senescent cells. This Ig, eluted from s... | 108,480 | [
0.01726299,
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Neurofibrillary pathology: current status and research perspectives. | The neurofibrils seen in the light microscope are shown, by electron microscopy, to be heterogeneous structures, formed of neurotubules and neurofilaments. A variety of pathological conditions (especially, presenile and senile dementia (are characterized by the presence of neurofibrillary tangles, formed either of pair... | 108,483 | [
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Identification of 15-keto-9, 11-peroxidoprosta-5, 13- dienoic acid as a hematin-catalyzed decomposition product of 15-hydroperoxy-9, 11-peroxidoprosta-5, 13-dienoic acid. | A labile prostaglandin was isolated as one of the products generated from [1-14C] eicosatetraenoic acid incubated with sheep vesicular gland microsomes. The eicosatetraenoic acid metabolite amounted to ca. 16% of the total radiolabeled products. Formation of this new prostaglandin was prevented when heat-denatured micr... | 108,495 | [
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0.31... |
[Determination of the limits of the physiological action of mineral elements in hydrogen bacteria]. | The growth of the hydrogen bacterium Hydrogenomonas eutropha Z-1 was studied in the conditions of continuous cultivation at different content of mineral elements in the medium. The physiological action of phosphorus, sulfur, potassium and magnesium in the bacterium was found to be displayed within a wide range of conce... | 108,530 | [
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0.252233,
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[Carcinoid of the digestive tract. Diagnostic possibilities (author's transl)]. | Special features which enable preoperative differential diagnosis are dealt with in detail with reference to 44 patient with carcinoid of the digestive tract. Carcinoid of the appendix becomes noticable early with signs of acute or chronic appendicitis and in 94% of cases is operated on in good time. Angiography of the... | 108,577 | [
-0.1441485,
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0.3319499,
0.4689415,
0.02575129,
-0.03998723,
... |
X-ray quality and the induction of meiotic recombination in Drosophila melanogaster males. | This paper reports a set of experiments designed to determine whether the radiation-quality effect, reported for the induction of somatic recombination, could be also demonstrated for meiotic recombination. Males heterozygous for markers on the 2nd chromosome were given an exposure of 600 R with either 55 kV or 100 kV ... | 108,594 | [
0.2565004,
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0.3280738,
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0.01117703,
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Videotaping epileptic attacks during stereoelectroencephalography. | Relating the onset of clinical attacks as recorded on a videotape to surface and depth electrographic events improves our ability to define the local or diffuse origin of seizures. In two patients with complex partial seizures, all 14 attacks appeared 3 to 6 seconds after focal discharges began in the amygdala or hippo... | 108,610 | [
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0.284357,
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[Visual future of prematures]. | The retinal periphery of 60 premature children now between 5 and 8 years of age and with a weight at birth equal or less than 1,500 g has been investigated. In 20% of these children, pigmentary modifications were noted which were often associated with chorioretinal atrophy. Polymorphic vascular abnormalities were seen ... | 108,644 | [
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0.2658355,
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0.4446772,
0.4239492,
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... |
Albinism. | There are seven forms of oculo-cutaneous albinism, which are all autosomal recessive: three are tyrosinase-negative (complete oculo-cutaneous albinism, Amish albinism, Hermansky-Pudlak syndrome) and four are tyrosinase-positive (incomplete oculo-cutaneous albinism, Chediak-Higashi syndrome, Cross syndrome, Bergsma's al... | 108,645 | [
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0.1467667,
-0.2288223,
-0.3125568,... |
Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: genetic model for immunodeficiency disease. | The inherited deficiency of purine-nucleoside phosphorylase (PNPase; purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) in humans is associated with a severe deficiency of the T lymphocytes of the immune system. Because of the unsatisfactory nature of previously described model systems, we have selected, ... | 108,675 | [
-0.1209478,
-0.3632308,
-0.3977462,
-0.2365315,
0.3038456,
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0.3724887,
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0.07608437,
0.2301053,
0.1420256,
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0.5471178,
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0.07132906,
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0.096245,
0.3642409,
0.01553846,
0.3049723,
-0.1960243,
0... |
Escherichia coli adenylate cyclase complex: regulation by the proton electrochemical gradient. | Sugars such as glucose are transported into Escherichia coli by a coupled phosphorylation mechanism (the phosphoenolpyruvate:sugar phosphotransferase system, PTS). Transport of sugars through the PTS results in inhibition of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity by a mechanism inv... | 108,676 | [
-0.319121,
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0.09670324,
0.1307731,
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0.1792616,
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0.3257958,
-0.05579706,
-0.2973135,
-... |
Effects of physostigmine, scopolamine, and mecamylamine on the sleeping time induced by ketamine in the rat. | Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rout... | 108,720 | [
0.2147638,
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0.3926634,
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0.03685718,
0.1776733,
0... |
Piracetam facilitates retrieval but does not impair extinction of bar-pressing in rats. | Rats were trained on a continuously reinforced bar-press response for water reward. Seven days later they were retested for retention, with or without pretest injection of the nootropic drug, piracetam. Drug-treated animals had significantly shorter response latencies than saline-treated animals. The results are interp... | 108,722 | [
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0.1620837,
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0.2639577,
-0.07228374,
0.0847833... |
The antagonizing effect of aspartic acid on morphine withdrawal and levallorphan-precipitated abstinence syndrome signs and on associated changes in brain levels of free amino acids in the rat. | We have previously demonstrated the antagonizing effect of aspartic acid on some effects of morphine and on the development of physical dependence on, and tolerance to, morphine. In the present study, we have withdrawal from morphine or administration of a morphine antagonist. For this purpose sixty five white rats wer... | 108,753 | [
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0.3327448,
0.3321702,
0.1261834,
-0.02508698,
-0.156235,
-0.1788968,... |
Treatment of prolactin-secreting pituitary tumours in young women by needle implantation of radioactive yttrium. | Twenty-one young female patients are described who presented with amenorrhoea, galactorrhoea or infertility, and were treated by 90Y pituitary implantation of 20,000 rads. There was no morbidity. In all patients serum prolactin values were elevated and radiographs of the pituitary fossa were abnormal. Observations are ... | 108,759 | [
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0.02321127,
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0.1019632,
0.3866346,
0.2013221,
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0.05906659,
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0.161433,
0.08696532,
0.02029938,
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0.3352985,
0.3262216,
-0.05569339,
... |
Long-term curative results of radiotherapy of patients with inoperable prostatic carcinoma. Erskine Memorial Lecture, 1978. | A series of 59 consecutive patients with inoperable carcinoma of the prostate were entered into a national cooperative study and treated under the tenets of a strict protocol with competent dosimetric control. Twenty-one of these men are living and well 5--10 years after treatment; nine others who lived without cancer ... | 108,762 | [
-0.2626271,
0.1646588,
-0.3146162,
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0.1476243,
0.04966283,
0.04226426,
0.1005114,
0.1679218,
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0.2887989,
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0.1414334,
0.2321115,
0.4178418,
0.2415963,
-0.173076,
-0... |
Quality Assurance in diagnostic radiology: an irreverent view of a sacred cow: annual oration in honor of Albert Soiland, M.D. | The problem of federal regulation of radiologic practice is examined via an in-depth analysis of the Proposed Recommendations for Diagnostic Radiology Facility Quality Assurance Programs as published in the Federal Register by the Commissioner of Food and Drugs. It is shown that the need for such recommendations is not... | 108,765 | [
-0.09095104,
0.3864226,
0.2873595,
0.15749,
0.009132151,
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0.1925734,
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0.15424,
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-0.1105708,
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-0.350045,
0.3511733,
-0.510848,
-0.006638351,
-0.2290451,
-0.1048177,
0.06091421,
-0.07268151,
-0.09776861,
... |
Antibodies against neurons in chronic Chagas' disease. | Severe qualitative and quantitative alterations of the autonomic system inervating the heart and other organs have been demonstrated in experimental and natural Chagas' disease. These facts led us to search for the presence of antibody to neurons in 230 chagasic sera by an indirect immunofluorescence technique. Our res... | 108,824 | [
0.2143445,
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0.08596727,
0.1071634,
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0.1297633,
0.09651355,
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0.2685109,
0.1006799,
0.2809122,
-0.04571158,
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-0.4807403,
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0.2228154,
-0.2210558,
-0.1323488,
-0.09060337,... |
[Importance of subclavian vein catheterization in the treatment of surgical diseases of the gastrointestinal tract]. | On the grounds of an analysis of 1095 catheterizations carried out upon patients with gastrointestinal diseases the authors have shown that the use of the subclavian vein for the infusion therapy is a method of choice for such patients. To prevent the complications the authors consider it imperiable to improve training... | 108,834 | [
-0.02581801,
-0.1208195,
-0.196818,
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0.1480592,
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-0.1466492,
-0.2956383,
-0.283615,
0.08691074,
0.3613692,
-0.07542256,
-0.1131403,
-0.4161916,
-0.2292647,
-0.2621117,
-0.233293,
0.08736874,
-0.1481485,
0.2814506,
0.4888265,
-0.2052949,
0.08440312,
... |
[New data on the tachyphylactic properties of sodium nucleinate]. | Sodium nucleinate, when injected into mice in combination with killed E. coli or prodigiozan, caused a decrease in side effects produced by the vaccine or polysaccharide. The combined injection of sodium nucleinate and prodigiozan in doses, ineffective if introduced separately, was accompanied by the potentiation of th... | 108,882 | [
-0.388213,
0.03563114,
-0.2948379,
0.07840173,
0.06794438,
-0.3165829,
-0.3098838,
-0.1919396,
0.1997138,
0.1034606,
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0.02662834,
0.006485775,
-0.2180637,
-0.5225533,
-0.2523025,
-0.1825149,
-0.1548181,
-0.04577755,
0.3985785,
0.7455003,
-0.006011163,
-0.067744... |
Duodenal plasmacytoma. A rare primary extramedullary localization simulating a carcinoma. | A patient with duodenal plasmacytoma is described. The extramedullary localization preceded the complete humoural picture of multiple myeloma by 15 months. The previously reported cases of myeloma of primary gastrointestinal localization are reviewed. | 108,892 | [
-0.4524293,
-0.09074181,
-0.3437051,
-0.3831131,
0.04796204,
-0.1201251,
-0.2937544,
-0.009673341,
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0.2362307,
0.293932,
0.1380126,
0.09986771,
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0.01723118,
-0.1344898,
0.1582636,
0.1150789,
-0.3683444,
0.2590472,
0.2791365,
0.09134421,... |
Use of specific antisera against leukemia-associated antigens in the diagnosis of childhood acute lymphoblastic leukemia. | A series of 66 children with acute lymphoblastic leukemia (ALL) at diagnosis were investigated (simultaneously) for various surface markers. For this purpose the reaction of specific antisera against ALL antigens and T cell antigens was analysed in every case by several test systems, namely immunofluorescence, microcyt... | 108,896 | [
-0.08405196,
0.0236479,
0.0454524,
0.09604593,
0.04160687,
-0.2756803,
-0.2552612,
0.1999862,
0.1010694,
0.3934273,
0.1028515,
0.3496913,
0.03628534,
0.1079664,
-0.1619785,
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-0.04936151,
-0.07744421,
-0.2293299,
0.2707336,
0.2981126,
-0.009729553,
-0.2411491,
... |
Structural and functional characteristics of hairy cells. | Morphological, cytochemical, immunological and ultrastructural studies were performed on peripheral blood mononuclear cells from a patient with hairy-cell leukemia. Immunofluorescence studies showed a very strong intensity of fluorescence and indicated that hairy cells had monoclonal surface-membrane immunoglobulins (S... | 108,897 | [
0.1114428,
-0.04602746,
-0.106845,
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0.08208388,
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0.1924131,
0.1797279,
0.2429862,
-0.01974034,
-0.156213,
-0.2489565,
0.339878,
0.008762534,
0.06760676,
-0.5376227,
-0.2720679,
0.05604782,
0.2013839,
0.5445963,
0.3127773,
0.02553961,
0.... |
Bowel habit in a Yoruba rural community: preliminary report. | The bowel habit of a rural population 80 kilometres outside Ibadan was examined. Based on the pattern of the diet there, 91% of the apparently healthy subjects have daily bowel actions, 60% have two or more motions a day and the stool was soft in 51% of them. There was no alteration in the frequency and consistency of ... | 108,935 | [
-0.07369643,
-0.2023771,
0.05165586,
0.1400695,
0.04120664,
-0.3014091,
0.01671943,
0.08499597,
0.1845604,
-0.02775312,
0.06225951,
0.1371937,
0.09583216,
0.1289206,
-0.3924443,
-0.06922824,
-0.6388928,
-0.01052234,
-0.1346656,
-0.1293792,
0.1066201,
0.4305363,
-0.1623061... |
Gastric volvulus in childhood. | Gastric volvulus, organoaxial or mesenteroaxial, is an uncommon cause of upper gastrointestinal obstruction in childhood. It may be suspected on plain radiographic examination of the abdomen and confirmed by upper gastrointestinal series. Seven affected children are described. In childhood, gastric volvulus often coexi... | 108,970 | [
-0.108091,
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-0.1530116,
-0.2555527,
0.1849833,
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0.1108507,
0.2616126,
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-0.2895011,
-0.0912056,
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0.2684728,
-0.004783582,
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0.03108597,
-0.0270379,
-0.1445261,... |
Osteoblastic response to successful treatment of metastatic cancer of the prostate. | Increasing sclerosis of bone in patients with prostatic cancer most commonly is associated with disease progression. In a study of serial radiographs in a group of 18 patients who experienced objective clinical remission after treatment of metastatic cancer of the prostate, eight (44%) showed an osteoblastic response a... | 108,971 | [
0.1882316,
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-0.09819164,
-0.2996289,
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0.2805167,
0.1654049,
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0.07129441,
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0.08705895,
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0.1518362,
0.1195657,
0.2974173,
0.3921045,
0.08327527,
-0.138026... |
Finger joint swelling: correlation with age, gender, and manual labor. | A soft tissue immersion radiography technique was used to study changes in 4,648 finger joints of 166 patients free from signs of inflammatory joint disease. An age-specific correlation was found for joint swelling, joint space narrowing, joint margin spurs, and intraarticular loose bodies. The distal interphalangeal j... | 108,973 | [
-0.1116357,
0.3118353,
0.2796499,
0.09001726,
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0.0002693647,
0.2874753,
0.04309125,
0.2185579,
0.1174916,
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-0.09743427,
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-0.1861966,
0.2424259,
-0.1953976,
0.04933198,
0.3187478,
0.1545461,
-0.2067808,
... |
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