title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Antibacterial activity of a new parenteral cephalosporin--HR 756: comparison with cefamandole and ceforanide. | HR 756, a new parenteral cephalosporin that is beta-lactamase resistant, was tested against 271 bacterial isolates. Both agar and broth dilution testing were employed, using two media and two inoculum sizes of bacteria. Antibacterial activity of the drug was compared to that of cefamandole (CFM) and ceforanide (CFN). I... | 112,919 | [
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[Automatic activity of the pre-excitation pathways]. | The possibility of preexcitation pathways exhibiting automatic activity was demonstrated in 3 cases: in two cases electrophysiological studies supported this diagnosis which was confirmed in the third case by histological examination of the preexcitation pathway. During sinus node dysfunction, spontaneous or induced (b... | 112,935 | [
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[Prinzmetal's angina initiated by interruption of exercise. 5 cases with normal coronary radiograms]. | Five male patients, aged between 31 and 58 years, presented with anginal chest pain with nausea and sweating after the interruption of exercise. Prinzmetal variant angina was observed during the recovery phase of exercise tolerance testing. Coronary arteriography and selective left ventricular angiography were normal i... | 112,938 | [
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[Effect of nitrate derivatives on the contractility and relaxation of papillary muscle in hypoxia and reoxygenation]. | The direct action of nitrate derivatives on myocardial contractility is not fully understood. The effects of Glyceryl Trinitrate (1 mM/L.) and Sodium Nitro prussiate (3 X 10(-5) M/L.) on papillary muscle were studied during 30 minutes hypoxia followed by 60 minutes reoxygenation: Both conditions were analysed every 5 m... | 112,941 | [
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New derivatives of 6-hyroxy-coumaranone-2-acetic acid with anti-prostaglandin activity. | Sixteen new amide and ether derivatives of 6-hydroxy-coumaranone-2-acetic acid (1) were synthetized, some of which were screened pharmacologically for anti-prostaglandin activity. | 112,946 | [
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Coagulation failure in babies with rhesus isoimmunization. | Serial prospective studies of coagulation status have been undertaken on 73 babies with a positive Coombs test. No abnormalities were detected in the babies with mild haemolytic disease, but seven of the 36 babies with severe haemolytic disease (cord Hb less than 11 g/dl or cord bilirubin greater than 85 mumol/1) showe... | 113,026 | [
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Physical growth and neurointegrative performance of survivors of protein--energy malnutrition. | 1. The anthropometric measurements and neurointegrative performance of seventy-nine children aged 6--12 years who had survived kwashiorkor in early childhood were compared to those of 142 children who served as controls. 2. For the boys the differences in height and weight between those who had survived protein--energy... | 113,027 | [
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Relation between erythrocyte selenium concentrations and glutathione peroxidase (EC 1.11.1.9) activities of New Zealand residents and visitors to New Zealand. | 1. Erythrocyte, plasma and whole blood selenium concentrations and glutathione peroxidase (EC 1.11.1.9; GSHPx) activities were measured (1) in 104 healthy New Zealand residents living in Otago, a low-soil-Se area (2) in sixty-four surgical patients, including nineteen patients on total parenteral nutrition and twenty-t... | 113,028 | [
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An agar--gel immunodiffusion test for detection of Brucella antibodies in human serum. | A comparison was made of results obtained with a Brucella agar--gel immunodiffusion (AGID) test and the standard tube-agglutination test on 612 human sera. Agreement between the tests was 97% when the titer was 1:160 or higher. Of 448 sera that showed no agglutination titer, 447 were negative with the AGID test. Result... | 113,073 | [
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Combined modality therapy of hepatic metastasis. Northern California Oncology Group Pilot Study. | Twenty-two patients with adenocarcinoma metastatic to the liver were treated with rapid fractionation whole-liver irradiation (1350-2100 rads in 300-rad fractions) with simultaneous intrahepatic 5-fluorouracil (10-15 mg/kg/day) and intrahepatic Adriamycin 2.5-10 mg/m2/day) as part of a Phase I-II study. Of the 21 patie... | 113,078 | [
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Modification of the effect of a gonadoliberin analog on 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors by hormone replacement. | A gonadoliberin analog, (D-leucyl6, desglycyl-NH2(10), prolyl ethylamide9) gonadoliberin, is known to suppress ovarian function and plasma prolactin levels. Its antitumor activity was evaluated against mammary tumors induced in Sprague-Dawley rats by dimethylbenz(a)anthracene. Observations were made when the analog, re... | 113,083 | [
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Influence of thyroid hormone on the development of peoptic-hypothalamic monoaminergic neurons in tadpoles of Bufo bufo japonicus. | The effect of thyroid hormone on the development of diencephalic monoaminergic neurons was studied in tadpoles of Bufo bufo japonicus. Monoamine-containing neurons in the preoptic recess organ (PRO) appeared later than those in the paraventricular organ (PVO) and nucleus infundibularis dorsalis (NID). After deprivation... | 113,102 | [
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[Association of brain glycoprotein (NSA 3) with neuronal membranes and with the nodes of Ranvier]. | The localisation of brain glycoprotein NSA 3 was studied by means of indirect immunofluorescence on alcohol fixed, paraffin embedded sections of Rat brain. These techniques allowed the localisation of NSA 3 to the membrane of some (about 10%) of the neurons. In the white matter, the patterns were in agreement with the ... | 113,115 | [
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[Synthesis of juvenile hormones in vitro by the corpora allata of 5th stage larva of Locusta migratoria migratorioides (R and F) (Insecta, Orthopteroida)]. | Corpora allata of Locusta migratoria 5th stage larvae synthesize J.H.1, J.H.2 and J.H.3 in vitro. The C.A. of insects of different ages exbit different rates of J.H. synthesis. J.H.1 and J.H.2 synthesis is less than 1 ng/48 h/gland. During the same time the J.H.3 production may be as much as 25.6 ng/gland. J.H. synthet... | 113,127 | [
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Progressive visual failure in acromegaly following external pituitary irradiation. | Four out of twenty-three acromegalic patients selected for treatment with external megavoltage pituitary irradiation between 1961 and 1975 developed progressive visual failure. They had received megavoltage external irradiation through multiple portals from a cobalt-60 unit over a period of 3 weeks. Visual deterioratio... | 113,142 | [
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The influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats. | The mechanisms of the anticonvulsant activity of cannabidiol (CBD) and the central excitation of delta 9-tetrahydrocannabinol (delta 9-THC) were investigated electrophysiologically with conscious, unrestrained cobalt epileptic rats. The well-known antiepileptics, trimethadione (TMO), ethosuximide (ESM), and phenytoin (... | 113,206 | [
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The behavioral effects of cocaine: rate dependency or rate constancy. | The behavioral effects of cocaine were studied in squirrel monkeys trained to press a response key under an 8-min fixed-interval (FI) schedule of electric shock presentation. Overall mean rate of responding increased at 0.03--0.3 mg/kg (i.m.) and decreased at 1.0--3.0 mg/kg. Increased responding during the initial and ... | 113,225 | [
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Effect of meseclazone and other non-steroidal anti-inflammatory drugs on isolated tracheal chain tone. | Meseclazone, 5-CSA and several representative NSAIDs caused concentration-dependent relaxation of the tracheal ring preparation and are listed in order of descending potency: isoproterenol greater than naproxen greater than ibuprofen greater than diflunisal greater than tolmetin approximately equal to fenoprofen approx... | 113,226 | [
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The effect of dietary fat on the anticoagulant activity of aflatoxin B. | A single i.p. dose of aflatoxin B1 had no significant effect on the thrombotest clotting times of monkeys subsisting on low-fat and high-fat dietary regimens, respectively. There was a significant interaction between aflatoxin and dietary fat level. | 113,251 | [
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Sites of breakdown of the blood-aqueous barrier after paracentesis of the rhesus monkey eye. | Sites of breakdown of the blood-aqueous barrier following rapid paracentesis have been investigated in rhesus monkeys with two independent procedures. (1) The entrance of fluorescein into the anterior and posterior chambers following paracentesis was studied in vivo in normal eyes, in eyes with laser-induced experiment... | 113,359 | [
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Response of the vestibulo-ocular reflex to differing programs of acceleration. | The vestibulo-ocular reflex of normal monkeys was tested by a modified Bárány spinning test (B-test) and by sinosoidal rotation. The two tests gave concordant estimates of the time constant and corner frequency. Deviation from concordance was caused largely by modification of the reflex during the testing procedures. A... | 113,360 | [
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Radioiodination of biologically active compounds: a simplified solid-state enzymatic procedure. | A simplified solid-state enzymatic iodination procedure for routine labeling of unstable pure protein or complex amino acid-containing molecules is presented. The procedure was designed using agarose-bound lactoperoxidase to iodinate human IgG with iodine-125. This method consistently resulted in a labeling efficiency ... | 113,367 | [
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Genetic and physiological characterization of Pseudomonas aeruginosa mutants affected in the catabolic ornithine carbamoyltransferase. | In Pseudomonas aeruginosa arginine can be degraded by the arginine "dihydrolase" system, consisting of arginine deiminase, catabolic ornithine carbamoyltransferase, and carbamate kinase. Mutants of P. aeruginosa strain PAO affected in the structural gene (arcB) of the catabolic ornithine carbamoyltransferase were isola... | 113,384 | [
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Effect of protein synthesis on plasmid maintenance in Streptococcus faecalis. | Plasmid-to-chromosome ratios in Enterobacteriaceae, upon interruption of protein synthesis by chloramphenicol, are either conserved or increased when measured by dye buoyant density centrifugation. We have found, on the other hand, that the effect of inhibition of protein synthesis on the amount of covalently closed ci... | 113,387 | [
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Structural components of sphingophosphonolipids from the ciliated protozoan, Tetrahymena pyriformis WH-14. | 1. Two sphingophosphonolipids were isolated from the lipids of the ciliated protozoan, Tetrahymena pyriformis WH-14. They were ceramide N-methyl-2-aminoethylphosphonate (CMAEP) and ceramide 2-aminoethylphosphonate (CAEP), in yields of 0.05 mg/g and 1.74 mg/g dry cells, respectively. 2. Two chromatographically distingui... | 113,397 | [
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Primary structure of a human IgA1 immunoglobulin. V. Amino acid sequence of a human IgA lambda light chain (Bur). | The sequence of the lambda light chain of the Bur IgA1 molecule has been determined. It comprises 214 amino acid residues with a blocked NH2 terminus and lacks carbohydrate. The V-region sequence is of the VlambdaII subgroup and contains the coupled interchanges Arg-7 and Cys-87. The Lv3 region is comparatively short a... | 113,407 | [
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Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion. | The development of gap junctions between pancreatic B-cells was quantitatively assessed in freeze-fracture replicas of isolated rat islets under different conditions of insulin secretion. The results show that in resting B-cells, gap junctions are small and scarce but that these junctions increase when insulin secretio... | 113,418 | [
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0.05577296,
0.08966124,
0.2841501,
0.5151505,
0.1374447,
0.2185485,
... |
Heterogeneity and some properties of beta-galactosidase from newborn rat epidermis. | Two forms of beta-galactosidase from newborn rat epidermis could be separated by DEAE-cellulose chromatography. Both enzymes showed similar enzymic properties. They had a pH optimum around 3.5--4.5 and the optimal temperature of these enzymes was approximately 60 degrees C. They were not affected by divalent cations, e... | 113,467 | [
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0.2440043,
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0.6588157,
0.3342913,
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... |
Determination of C1q in human sera. | All detectable C1q in serum is precipitated with the euglobulin fraction, and all other detectable hydroxyproline-containing protein in serum is excluded from this fraction. Since C1q contains 4.3% hydroxyproline, an estimate of its content in serum can be calculated by multiplying the hydroxyproline content of the eug... | 113,476 | [
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0.2465417,
0.2079764,
0.04690387,
0.06552865,
... |
Effect of bacteriophage C5 on ultraviolet light survival in Pseudomonas aeruginosa. | Bacteriophage C5 of Pseudomonas aeruginosa is able to reactivate ultraviolet (u.v.)-irradiated phage E79 in coinfection experiments and decrease the u.v.-sensitivity of a host-cell reactivation deficient mutant. These properties suggest that phage C5 has a gene(s) which is involved in the repair of u.v.-damaged DNA. Th... | 113,492 | [
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0.1592133,
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0.2219635,
0.02931728,
... |
Demonstration of hepatitis B e antigen (HBeAg) in association with intact Dane particles. | Mild detergent treatment (0.1% Sarkosyl-0.1% beta-mercaptoethanol) of Dane particle-rich fraction from human serum resulted in the release of core particles together with HBe antigen activity when examined by the reversed passive haemagglutination method. Furthermore, when the core particles isolated by the above proce... | 113,499 | [
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0.3642325,
0.07226197,
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-0.1910308,
-0... |
Morphology and morphogenesis of a new paramyxovirus (PMV 107). | The morphology of the virions and nucleocapsids of paramyxovirus 107 (PVM 107) and the replication of the virus were investigated by electron microscopy. The virions and nucleocapsids exhibited the same structural properties as other paramyxoviruses. Nuclecapsids were found in the nucleus and cytoplasm of infected bovi... | 113,501 | [
-0.2949323,
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0.3925201,
0.09055769,
0.8449207,
0.4642243,
-0.16200... |
Autonomic innervation of the mammalian penis: a histochemical and physiological study. | The distribution of adrenergic and cholinergic nerves was studied in penile tissue from rat, rabbit, cat, monkey and man. Glyoxylic acid histofluorescence and acetylcholinesterase-positive fibers were found in all tissues examined, but histofluorescent, presumably adrenergic fibers predominated. In general, except in t... | 113,505 | [
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0.1865263,
0.3349831,
0.4166582,
0.154273,
0... |
Effects of systemic and intraventricular administration of cannabinoids on schedule-controlled responding in the squirrel monkey. | The effects of a number of cannabinoids in squirrel monkeys trained to respond on a chain fixed-interval fixed-ratio schedule of food presentation were determined after intraperitoneal (i.p.) and intraventricular (i.v.t.) administration. The order of potency was (+/-)-9-nor-9 beta-OH hexahydrocannabinol, 11-OH-delta 9-... | 113,528 | [
-0.2223896,
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0.5014765,
0.1124187,
0.2033921,
0.02370646,
... |
A twinning event in Macaca sylvanus of Gibraltar. | Linear measurements and body proportions for a set of free-ranging Macaca sylvanus twins are presented. Their measurements are compared to a full-term perinatal dead female. The twins are dizygous and probably 28 days premature. | 113,541 | [
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A longitudinal study of facial growth in Papio cynocephalus after resection of the cartilagenous nasal septum. | The present study evaluates in Papio cynocephalus the effectiveness of varying the amount of nasal septum resected and the age at surgery in an attempt to develop a technique which may have clinical value for the human condition. The analysis of interdental dimensions by graphical techniques demonstrates that a critica... | 113,543 | [
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0.2277543,
0.03660696,
-0.09477... |
Predictive criteria for length of nasogastric tube insertion for tube feeding. | This study was aimed at identifying non-invasive techniques and criteria for predicting the proper length for insertion of a nasogastric tube for tube feeding so that the tube tip would be located in the fundus or body for the stomach. A review of literature and existing practices revealed unsubstantiated and discrepan... | 113,579 | [
-0.196807,
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0.1516022,
0.06979147,
0.1759424,
... |
Ultrastructure of normal monkey liver. | The normal ultrastructure of the liver of rhesus and cynomolgus monkeys is described. A classification of type A and B periportal hepatocytes is introduced together with a discussion of the high incidence of mitochondrial abnormalities. It is suggested that the rhesus monkey is more suitable as an experimental model th... | 113,618 | [
-0.03206943,
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0.03888232,
0.2074233,
0.3548355,
0.06350368,
... |
Primary malignant melanoma of the esophagus: report of two cases. | Two cases of primary esophageal malignant melanoma diagnosed at the Columbia-Presbyterian Medical Center are reported. One patient who received 3800 rads and had subsequent surgery lived for 18 months. The other had surgery and subsequent chemotherapy and is still alive three years later. Forty other cases reported in ... | 113,625 | [
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0.05751837,
0.3880385,
0.3951479,
-0.101144,
0.1... |
Physical factors affecting absorbed dose to the skin from cobalt-60 gamma rays and 25-MV x rays. | When there is an absence of scattering material adjacent to the skin on the exit side of a megavoltage beam the dose to the skin is less than would be calculated using depth dose tables or isodose distributions measured in "semi-infinite" phantoms. Ionization measurements using a thin-window parallel-plate chamber show... | 113,655 | [
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0.1383968,
0.1241998,
0.1551482,
0.5539703,
0.3171618,
0.099268... |
[Effect of a dietary regimen with separated administration of protein on liver in the rat]. | Rats received a protein-deficient standard diet and, separately at different hours of the day, protein (casein). The control group was given the standard diet added with casein. The livers of the rats were examined for histological and ultrastructural changes. The smallest changes were observed in animals which had rec... | 113,682 | [
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0.08904582,
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0.2331797,
-0.00922641... |
Transplacental effects of ethylnitrosourea in a nonhuman primate, Erythrocebus patas. | A breeding colony of the Old World monkey Erythrocebus patas, an African species, has been established to study transplacental carcinogensis in a representative primate species. ENU was administered by repeated iv injections to pregnant females and to juveniles of both sexes. Repeated doses of 0.1 mmole/kg body weight ... | 113,683 | [
0.0210359,
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0.03239651,
0.1851867,
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-0.250... |
A structure-activity study on the influence of phenolic compounds and bioflavonoids on rat renal prostaglandin synthetase. | The stimulating or inhibiting influences of 33 phenolic compounds on the prostaglandin synthetase of rat renal medulla were tested. Dihydroxyphenylcarbonic acids clearly proved to be activators of the prostaglandin synthetase. Dimethoxyphenylcarbonic acids were ineffective. Aminoethylphenols as well as p-substituted mo... | 113,685 | [
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0.3297062,
0.4052047,
-0.2888521,
... |
The anatomy of the subglottic larynx. | There is little concensus concerning the boundaries of the subglottic space. To better define the subglottis, 50 head and neck surgeons were asked to define its anatomic limits. In addition, the larynx of each of 50 adult cadavers was removed and four measurements in the anterior subglottis were taken. The results reve... | 113,732 | [
-0.08477429,
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0.227463,
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0.5719923,
0.1902639,
-0.115... |
Blunt laryngotracheal trauma. | Management of blunt trauma to the larynx and trachea is based upon accurate assessment of the anatomic site of the injury, the tissue involved, the time since the injury, and the general status of the patient. Early and orderly diagnosis and classification result in early management, which is essential to maximize func... | 113,750 | [
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0.2953995,
0.1092742,
-0.20910... |
Rhytidectomy (face-lift) in the otolaryngologic practice. | A surgical procedure is described that minimizes the lifting of the hairline in rhytidectomy by locating most of the incision inside the hair. Traction of the skin is directed at producing a soft, rounded contour. The author reports good results on 30 patients in two years' time. Appropriateness of rhytidectomy depends... | 113,751 | [
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0.3587742,
0.3472444,
-0.01950255,
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Acquisition of behavioral tolerance to ethanol as a function of reinforced practice in rats. | The roles of both reward and the amount of reinforced practice on the development of behavioral tolerance to ethanol were studied in 32 hooded rats in a Skinner-box situation. The effects of ethanol were evaluated on two aspects of the bar-press response (FR15): latency to complete 15 bar presses and proficiency to ear... | 113,815 | [
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0.09680819,
0.2411778,
0.3442701,
0.2239413,
-0... |
Dopaminergic mechanisms and cognitive deficit in schizophrenia. A neurobiological model. | A hypothesis is briefly discussed proposing that schizophrenic symptoms are due to a breakdown in a mechanism by which conscious attention is limited and directed. It is shown that this mechanism can be modelled in terms of a simple nerve network in which every channel inhibits all the others. Failure of this inhibitio... | 113,814 | [
-0.02970154,
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0.2443441,
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0.1540438,
0.013603,
-... |
The effect of propranolol treatment in shizophrenia on CSF amine metabolites and prolactin. | Recent reports have suggested that high doses of propranolol may be an effective treatment in schizophrenia. To determine whether such treatment has effects on cerebrospinal fluid (CSF) amine metabolites and prolactin similar to the effects of the neuroleptic drugs, we studied CSF from ten patients before and after pro... | 113,817 | [
-0.09769914,
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0.02377823,
0.1138092,
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-0... |
Facilitation of memory processing by posttrial morphine: possible involvement of reinforcement mechanisms? | Posttrial administration of 40 mg/kg and 100 mg/kg, but not of 1 mg/kg, of morphine hydrochloride facilitates learning of a one-trial passive avoidance task in drug-naive mice. The effect does not depend on the punishing properties of the morphine injection, since in injection of LiCl (a strong punisher) fails to enhan... | 113,818 | [
-0.1658297,
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0.1777239,
0.06065188,
0.4027505,
-0.2665024,
0.02501251,... |
Chlordiazepoxide-induced disruption of discrimination behaviour: a signal detection analysis. | To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/re... | 113,820 | [
-0.01286982,
0.07889855,
-0.2976595,
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0.1290521,
-0.4507636,
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0.3524258,
-0.1753506,
0.05199282,
0.3392533,
... |
3-Methoxy-4-hydroxyphenylglycol excretion in acutely schizophrenic patients during a controlled clinical trial of the isomers of flupenthixol. | Urinary MHPG excretion in patients with acute schizophrenia was studied before and during a trial of the isomers of flupenthixol and placebo. Pretrial MHPG excretion was not related to severity of illness before the trial or to other pretrial clinical variables. In male subjects higher pretrial MHPG excretion was assoc... | 113,829 | [
-0.07143328,
0.1720569,
-0.4103709,
-0.4651194,
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0.246572,
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0.2188565,
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0.07889358,
-0.2573137... |
Memory facilitation with posttrial injection of oxotremorine and physostigmine in mice. | The immediate posttrial injection of oxotremorine (0.125, 0.250 and 0.500 muMol/kg i.p.) and equimolecular doses of physostigmine can facilitate the retention of a passive avoidance response in mice. Injections given 10 min after training also significantly facilitate retention, but injections given 30 or 120 min after... | 113,837 | [
-0.2773593,
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0.1682111,
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0.1311452,
0.1052135,
0.1267029,
0.2424416,... |
Organization of the immune response genes. | The I region of the major histocompatibility complex contains immune response genes that display considerable polymorphism; that is, there are many alleles at each locus. These genes regulate the immune response to antigen by mediating intercellular communication among lymphoreticular cells. An analysis of the primary ... | 113,876 | [
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0.201109,
0.2004386,
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... |
Demeclocycline in the treatment of the syndrome of inappropriate secretion of antidiuretic hormone. | Fourteen patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have been treated with demethylchlortetracycline (demeclocycline) 1200 mg daily. In 12 patients the underlying lesion was malignant. The serum sodium returned to normal (greater than 135 mmol/l) in all patients after a mean o... | 113,900 | [
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-0.2141994,
0.1212322,
0.08020063,
0.1480877,
0.02057459,
0.1836976,
0.06159203,
0.3455352,
-0.2781596,
0.1105353,
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-0.1158976,
-0.2021201,
0.1475252,
0.1612019,
0.208944,
-0.03591935,
-0.01... |
Ocular and orbital manifestations of neurofibromatosis. | The ocular and systemic manifestations of von Recklinghausen's neurofibromatosis are reviewed. A case is presented illustrating widespread involvement and the typical histopathologic changes of the eye and the ocular adnexa. The ophthalmologist should be aware of broad scope of this disorder so that a complete evaluati... | 113,898 | [
-0.0401614,
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0.1839785,
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[Polychlorinated biphenyl intoxication and nutrition. III. Effect of vitamin A deficiency on PCB storage in the rat (author's transl)]. | Rats were fed two dietary variations containing 10 ppm of Phenoclor DP6 (a commercial PCB mixture) for 15 days. Compared to the normal diet, rats fed a vitamin A deficient diet had a same curve of DP6 storage in liver and carcase fat. The intestinal absorption of DP6 was unaffected by vitamin A deficiency. The accumula... | 113,910 | [
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0.031891,
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0.2064612,
0.09953153,
0.3744232,
-0.1854688,
0.037... |
CELISA (complement-enzyme linked immuno sorbent assay) a new method for the estimation of complement fixing antibodies; its use for Chagas' disease. | A description is given of a new method for the estimation of complement fixing antibodies. This is a modification of the Enzyme Linked Immuno Sorbent Assay (ELISA) to a Complement-Enzyme Linked Immuno Sorbent Assay (CILISA) using an anti-C3 conjugate. The method is independent of the haemolytic system. To test the sens... | 113,915 | [
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0.3808818,
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... |
[Evolutionary origin of cell organelles]. | A review on the evolutionary origin of the energy-yielding eukaryotic organelles is presented. Current autogenetic (endogenous compartmentalization) schemes, as well as different variants of symbiogenesis, are critically envisaged. A new symbiogenetic scheme is put forth, according to which mitochondria and chloroplast... | 113,918 | [
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0.3678676,
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... |
Transmission of Sarcocystis suihominis from humans to swine to nonhuman primates (Pan troglodytes, Macaca mulatta, Macaca irus). | Sporocysts of Sarcocystis suihominis obtained from human feces were used to infect swine. Heart, tongue, and skeletal muscle from experimentally infected and noninfected control swine were fed via stomach tube to nonhuman primates including chimpanzees (Pan troglodytes), rhesus monkeys (Macaca mulatta), and cynomolgus ... | 113,949 | [
-0.4064746,
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-0.1195334,
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-0.06137146,
0.1226308,
0.4301038,
0.1011... |
Studies on a receptor for pyocin in a R mutant of Salmonella minnesota. | Lipopolysaccharide (LPS) isolated from the pyocin sensitive R form strain of Salmonella minnesota F6 (chemotype Rd1) inhibited the activity of bacteriophage tail-like pyocin P1 whereas no inhibition occurred with LPS prepared from the pyocin resistant S form of S. minnesota. Subunits of lipopolysaccharide obtained by t... | 113,953 | [
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... |
[Studies to investigate the ecological importance of the mass development of Hydrodicyton reticulatum in infiltration basins for drinking water. II. Localization of the active components with the aid of thin-layer chromatography and bioassay detection (author's transl)]. | Thin-layer chromatogramms made from ethanol extracts of the green fresh-water alga H. reticulatum were tested by bioassay detection against several strains of Bac. subtilis. The chromatogramms were overlayed with agar, seeded with the test strains. The production of two growth-inhibiting zones could be demonstrated (Fi... | 113,957 | [
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... |
Effect of diabetes therapy on the myocardium in experimental diabetes. | The effects of chronic antidiabetic treatment were examined in a clinically manifest, but non-ketotic diabetic animal model in which increased stabilization of steric structure in the cardiac connective tissue and left ventricular diastolic stiffness have been demonstrated. These changes accounted for decreased left ve... | 113,974 | [
-0.167203,
0.5567206,
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0.06790922,
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0.154367,
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0.1313401,
-0.1816703... |
Cortical potentials associated with vocalization in the rhesus monkey. | Cortical potentials associated with vocalization have been investigated in two rhesus monkeys. In both animals a slow negative potential shift beginning approximately 1 sec prior to the onset of vocalization has been observed in transcortical recordings from precentral areas. It is suggested that this slow potential ch... | 113,982 | [
-0.1575697,
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0.1517626,
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0.1820001,
0.073247... |
T4, T3 and reverse-T3 determinations in connection with the TRH test in the evaluation of possible hyperthyroidism. | One disadvantage of the TRH test is that an absent or blunted TSH response is seen not only in hyperthyroid patients but also in some normal subjects. The aim of the present study was to elucidate whether the discriminatory power between eu- and hyperthyroidism could be increased by determining the T3 and T4 levels bef... | 113,985 | [
-0.05046394,
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0.2440819,
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0.1734769,
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Carditis associated with mycoplasma pneumoniae infection. | Among 560 patients with serologically confirmed Mycoplasma pneumoniae infection, 25 (4.5%) had carditis (19 perimyocarditis, 6 pericarditis). During the acute phase 9 patients required intensive care. After an average of 16 months follow-up 11 patients with no previous signs of heart disease still had cardiac symptoms ... | 113,988 | [
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0.1284313,
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Pyloroduodenal bleeding and intraarterial vasopressin: clinical results. | Intraarterial vasopressin infusions were given to 46 patients with pyloroduodenal hemorrhage. Hemorrhage was angiographically and clinically controlled in 15 patients, with recurrent bleeding in five. Bleeding was not controlled in 31 patients; seven of these underwent Gelfoam embolization, with bleeding controlled in ... | 114,008 | [
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0.09457494,
0.1238231,
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0.2516765,
0.01330323,
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CT of the renal cyst: is cyst aspiration necessary? | Fifty patients with a total of 56 renal masses discovered on routine excretory urography or abdominal plain films and with ultrasonographic diagnoses of definite or probable benign cysts underwent computed tomography (CT) prior to cyst aspiration with cytologic study. All lesions met strict criteria for the CT diagnosi... | 114,010 | [
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0.1660989,
0.1328167,
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0.... |
Radiographic evaluation of the spine after surgical correction of scoliosis. | Scoliosis is frequently a progressive deformity despite the best efforts at external bracing and various exercises. In childhood, scoliosis is usually insidious and is rarely symptomatic. In later years, however, scoliosis leads to cardiopulmonary compromise, neurologic dysfunction, degenerative joint disease, and cosm... | 114,017 | [
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0.2144012,
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-0.15018... |
Lung metastases in cervical and endometrial carcinoma. | Carcinoma of the cervix or endometrium was evaluated in 1,021 patients at the Joint Center for Radiation Therapy, Boston, between July 1968 and December 1977. The patients were retrospectively evaluated for the presence of lung metastases, appearing initially or during their disease course. On chest radiography, 42 pat... | 114,020 | [
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0.2995661,
0.1838099,
-0.038... |
Brief clinical reports: aprosencephaly-atelencephaly and the aprosencephaly (XK) syndrome. | We report on a postnatally dead, postterm male infant with aprosencephaly and the oculofacial manifestations usually seen in the most severe form of alobar holoprosencephaly -- namely cyclopia and absence of derivatives of the frontonasal process; in addition the infant had the radius aplasia field defect bilaterally, ... | 114,053 | [
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0.04486074,
-0.3901947,
0.3872186,
0.09520658,
-0.109353... |
Vitreoretinal degeneration as a sign of generalized connective tissue diseases. | Dominant vitreoretinal degeneration was first described by Wagner as a benign ocular condition. This term has since become widely associated with a familial retinal degenerative process accompanied by retinal detachments, even though nobody in the family described by Wagner suffered from a retinal detachment. Vitreoret... | 114,056 | [
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0.0... |
Studies on the 2,4-diamino-6-substituted quinazolines. II. Activities of selected derivatives against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmodium vivax in owl monkeys. | Four 6-thio-, one 6-sulfinyl-, and two 6-sulfonyl-substituted 2,4-diaminoquinazolines were evaluated for capacities to cure established infections with the chloroquine-resistant Vietnam Oak Knoll and pyrimethamine-resistant Malayan Camp-CH/Q strains of Plasmodium falciparum in owl monkeys. As compared with the doses of... | 114,065 | [
0.004259835,
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[Risk hypothesis in the use of "non-carbon copy paper"]. | Some kinds of "carbon less copy-paper" presently used in Italy were examined. The analysis showed the presence on the paper of mycrocapsules containing special inks formed by organic dyes dissolved in mineral oil and, sometimes, polychlorobyfenils. Therefore there is a possible risk for the workers using carbon less co... | 114,077 | [
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0.2030765,
0.1477939,
0.2209464,
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... |
Transfer of R factors to and between genetically marked sublines of Rhizobium japonicum. | Plasmids R1822 and pRD1 of the P-1 incompatibility group, for which Rhizobium japonicum had not previously been shown to serve as host, were introduced into a strain of R. japonicum. Acquisition of R68 and R68.45 plasmids by this Rhizobium was equivocal. Transfer of R1822 from Pseudomonas aeruginosa and of pRD1 from Es... | 114,109 | [
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0.05217994,
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0.3469568,
0.01641391,
0.008749465,
0.1237983,
0.076791,... |
Redox potential-dependent nitrite metabolism by Salmonella typhimurium. | Salmonellae are generally resistant to the inhibitory effects of NaNO2. Removal of the lipopolysaccharide of Salmonella typhimurium by ethylenediaminetetraacetic acid pretreatment did not result in subsequent inhibtion of growth by NaNO2, indicating that lipopolysaccharide does not function to exclude NaNO2 from the ce... | 114,115 | [
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0.2884695,
0.204122,
-0.05094903,... |
Asymmetric diphenol formation by a fungal laccase. | A laccase isolated from the fungus Rhizoctonia praticola catalyzed the cross-coupling of two differently halogenated phenols. When 2,4-dichlorophenol and 4-bromo-2-chlorophenol were incubated together with the enzyme, three dimers were formed and isolated by thin-layer chromatography. The molecular weights of these com... | 114,116 | [
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0.1735101,
0.3693029,
-0.2594... |
Metabolic and hormonal responses of low birthweight infants to intravenously infused calories not exceeding the maintenance energy expenditure. | Eithe low birthweight infants were studied for their metabolic and hormonal responses to intravenous alimentation when the caloric input was varied. The study was made during three consecutive 12-hour periods, when solutions of glucose, glucose and amino-acids, and glucose and amino-acid and lipids were successively in... | 114,120 | [
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0.2923483,
0.3696351,
-0.1164067... |
Characterization of the exfoliative antispermatogenic agent 1-(2,4-dichlorobenzyl)-H-indazole-3-carboxylic acid in the rhesus monkey. | The effects of oral doses of 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (DICA) on spermatogenesis in the rhesus monkey (Macaca mulatta) was studied. Four animals given five daily 50 mg/kg doses or three or five daily 500 mg/kg doses showed that DICA was an exfoliating antispermatogenic compound. The inhibitio... | 114,129 | [
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0.325653,
0.326458,
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-0.... |
[Left ventricular cineangiography in the convalescent phase of a 1st myocardial infarct. Influence of coronary lesions]. | 80 patients with a primary myocardial infarction (32 anterior and 48 posterior) underwent cardiac catheterisation and angiography (coronary arteriography and selective left ventricular cineangiography) within 12 months of infarction. Analysis of the results of catheterisation and angiography showed: -- Diffuse coronary... | 114,133 | [
-0.0176497,
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0.3618249,
-0.03712862,
0.2866162,
0.5826706,
0.03179018,
-0.107... |
[Congenital arteriopathies and Leo Buerger's disease]. | A homogenous series of 7 consecutive cases of Buerger's disease were investigated and the congenital malformations of the upper and lower limb arterial trunks were classified. These malformations constitute the anatomical basis of Buerger's disease and define an autonomous disease entity. Total supra-malleolar interrup... | 114,139 | [
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... |
A case for further quantification of the stapedius reflex. | Clinical stapedius reflex determinations presently include only threshold and decay measurements. Recent observations indicate that reflex latency, amplitude, and rise and relaxation times are sensitive to cochlear and brain stem disorders. Our investigations using a chronic animal model of an experimental acoustic tum... | 114,150 | [
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-0.2811719,
0.04746003,
-0.3809398,
-0.1189988,
0.2129145,
-0.322713,
0.1634023... |
Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene. | Five dihydrodiols derived from benz[a]anthracene (BA) and 4 dihydrodiols derived from 7,12-dimethylbenz[a]anthracene (DMBA) have been tested, together with the parent hydrocarbons, for their abilities to induce mutations to 8-azaguanine resistance in V79 (Chinese hamster cells and malignant transformation in M2 mouse f... | 114,201 | [
-0.2906131,
0.2130937,
-0.2730745,
-0.2366192,
0.1366909,
0.02842346,
-0.03420971,
-0.07975067,
0.2362552,
-0.1743006,
0.03093354,
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0.1859804,
0.0387371,
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-0.374441,
0.4251497,
0.3089566,
0.0447816,
0.1649294,
-0.0776907,
-0.2693494,
-0... |
Amino acid sequence of the heavy-chain variable region of the crystallizable human myeloma protein Dob. | The amino acid sequence of the heavy-chain variable region of the crystallizable human myeloma protein Dob has been determined. This protein has previously been shown to have a deletion in the hinge region [Lopes, A. D., & Steiner, L. A. (1973) Fed. Proc., Fed. Am. Soc. Exp. Biol. 32, 1003; Steiner, L. A., & Lo... | 114,209 | [
-0.1702861,
0.1042171,
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0.07687483,
0.1517579,
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0.1709625,
0.2773831,
0.1026167,
0.07578404,
0.1004948,
0.1533025,
0.188826,
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0.03426901,
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-0.1292845,
0.2434307,
0.06149182,
0.1536132,
0.4454385,
-0.1193092,
0.1107... |
Interaction of divalent cations with beta-galactosidase (Escherichia coli). | Although the addition of various divalent metals to beta-galactosidase resulted in apparent activation, only Mg2+ and Mn2+ actually did activate. The apparent activation by the other divalent metals was shown to be due to Mg2+ impurities. Calcium did not activate, but experiments suggested that it did bind. Other dival... | 114,210 | [
-0.1694248,
0.1386368,
-0.4055659,
0.1035596,
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0.1218068,
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-0.2757813,
0.01414731,
0.0498909,
0.04929462,
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0.2011517,
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0.07442557,
-0.040189,
0.0977376,
0.3553988,
0.3551033,
-0.09819733,
0.23... |
Purification of the messenger ribonucleic acid for the lipoprotein of the Escherichia coli outer membrane. | The mRNA for the lipoprotein of the Escherichia coli outer membrane has been purified to 85% homogeneity. The purification procedure involved phenol extraction, NaCl extraction, gel filtration on Sephadex G-100 and Sephadex G-200, and reversed-phase column chromatography on RPC-5. The purity of the final product was es... | 114,211 | [
0.1634032,
0.07162096,
-0.1248519,
-0.2894907,
0.1771359,
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0.01447962,
0.2082962,
-0.08627383,
0.06907288,
0.2461746,
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0.3064403,
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0.05078242,
-0.2895897,
-0.003827487,
-0.1803477,
0.03775927,
0.5348842,
0.128569,
-0.4695989,
... |
Photoreaction center of photosynthetic bacteria. 2. Size and quaternary structure of the photoreaction centers from Rhodospirillum rubrum strain G9 and from Rhodopseudomonas sphaeroides strain 2.4.1. | The photoreaction center from Rhodospirillum rubrum strain G9 binds about 6 times as much sodium dodecyl sulfate as certain proteins commonly used as molecular weight markers for sodium dodecyl sulfate--polyacrylamide gel electrophoresis. This presumably explains the apparent discrepancy between the molecular weight of... | 114,213 | [
-0.05944723,
0.1611317,
-0.1382771,
-0.1768506,
-0.09593689,
-0.5068683,
-0.07337599,
0.1073487,
0.3541282,
0.2582212,
0.04068095,
-0.125797,
-0.3350848,
0.0761588,
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-0.30857,
0.06494845,
0.4169827,
-0.1972489,
0.1795424,
0.1705263,
-0.1253229,
-... |
Circular dichroism of lipoxygenase-1 from soybeans. | The circular dichroism spectra of the three forms of lipoxygenase-1 from soybeans show characteristic differences in the region between 300 and 600 nm. Native lipoxygenase-1 only shows a negative dichroic band around 330 nm. Yellow lipoxygenase-1, obtained by addition of an equimolar amount of 13-F-hydroperoxylinoleic ... | 114,226 | [
-0.1804418,
0.2423501,
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-0.2031327,
0.08695084,
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0.09772402,
0.3047051,
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0.1195749,
0.3058218,
0.07972396,
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0.2555308,
-0.509017,
0.2515994,
0.2002608,
-0.08800469,
0.3392667,
0.6486422,
-0.3119382,
0.15... |
Inhibition of tyrosinase by indole compounds and reaction products. Protection by albumin. | Tyrosinase activity decreases as the reaction proceeds and is inhibited by L-3,4-dihydroxyphenylalanine oxidation products. Indole and tryptophan inhibit tyrosinase reaction and bovine albumin protects against end-product(s) inhibition or inactivation. Since the same tyrosinase reaction products are indole compounds an... | 114,228 | [
-0.1729645,
-0.04128443,
-0.2093351,
-0.1760629,
0.3221522,
-0.07465644,
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0.1907461,
0.1853499,
-0.2076489,
0.1191542,
0.01834851,
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0.08663769,
-0.3129022,
0.2025851,
0.24834,
0.1879128,
0.002449175,
0.1676817,
-0.3945665,
... |
[Comparative study of microsomal enzymic activities in adult and foetal monkey hepatocytes (author's transl)]. | Differential centrifugation was applied to adult and foetal liver of monkey. Obtained fractions were: F1 (800 X g); F2 (12 500 X g); F3 (200 000 X g); and cell sap. Analysis of chemical compounds of these fractions shows that: (1) adult and foetal nucleic acids levels are similar; (2) there are more proteins in adult t... | 114,230 | [
0.02749898,
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0.04230651,
0.4159332,
0.06457491,
-0.41456,
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0.08513663,
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0.05702016,
0.06873536,
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0.149427,
0.4490095,
0.4135872,
-0.006768984,
-0.2581828,
... |
Size measurements on isolated rat heart cells using Coulter analysis and light scatter flow cytometry. | Isolated ventricular muscle cells from the adult rat heart have been examined by both Coulter analysis and light scatter flow cytometry. The dispersed cell preparations contain two main cell types: viable, rod-shaped cells and damaged, round cells. Coulter analytical techniques provided statistical data on cell volume ... | 114,233 | [
-0.1466179,
0.08701602,
-0.2422327,
0.1036638,
0.3179378,
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0.07072536,
0.2863044,
0.05507597,
0.3008104,
0.02224097,
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0.08422885,
-0.2887722,
-0.02632287,
-0.06975606,
0.1649777,
0.5557207,
0.025769,
0.08112016,
... |
The decrease of guanine nucleotides initiates sporulation of Bacillus subtilis. | Massive sporulation of Bacillus subtilis normally begins when carbon, nitrogen or phosphorus sources able to support rapid growth are no longer available. Sporulation can also be induced in exponentially growing cultures, in the presence of rapidly utilizable ammonia, glucose and phosphate if growth is partially but no... | 114,234 | [
-0.1785953,
0.2756957,
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0.2645656,
0.02854251,
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0.133812,
-0.150676,
0.1099339,
0.139753,
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0.1401893,
-0.06312179,
-0.02061678,
0.07205339,
0.05891921,
0.4582394,
0.1214374,
-0.05767658,
... |
Dynamics of a long-latency reflex pathway in the monkey. | Angular wrist displacements in the monkey result in a short-latency (20--25 ms) "reflex" response of motor cortical cells in area 4 and separate peaks of activity in the gross EMG of the stretched muscles. Frequency domain analysis was carried out between (1) wrist position as input and motor cortical neuron response a... | 114,239 | [
0.2275581,
-0.2671252,
-0.2110249,
-0.2633732,
-0.04697321,
-0.4007289,
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0.06816871,
0.06859867,
0.1297188,
0.002708821,
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0.08789878,
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-0.3876098,
0.2445309,
-0.127305,
0.1894983,
0.5073036,
0.2289048,
0.1034121,
... |
[Transmissible modification induced in Mycobacterium tuberculosis and Mycobacterium bovis in vitro]. | A biologically active material (fraction "S") is isolated from cultures of scotochromogenic mycobacteria. Mycobacterium tuberculosis, or Mycobacterium bovis by disrupting the cells, sedimentation through 2.2 M sucrose, and ultrafiltration. The fraction "S" induces the modification of tubercle bacilli into non acid-fast... | 114,293 | [
-0.1931905,
-0.1253208,
0.1254896,
0.3105465,
0.1147225,
-0.3709039,
-0.4513927,
0.05364805,
0.3575009,
-0.09256683,
0.02525453,
0.06919769,
0.2938575,
0.2650494,
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0.05018046,
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-0.3513822,
0.1127219,
0.1976035,
0.1746503,
-0.06492951,
-0.1636275,
-... |
The ineffectiveness of analogs of D-galactal as competitive inhibitors of, and substrates for, beta-D-galactosidase from Escherichia coli. | 2,6-Anhydro-3-deoxy-aldehydo-D-lyxo-hept-2-enose (7) and 2,6-anhydro-3-deoxy-D-lyxo-hept-2-enitol (8) were synthesized as half-chair analogs of D-galactal (1). As 1 is a strong inhibitor of, as well as a substrate for, beta-D-galactosidase from Escherichia coli, the same properties were expected for 7 and 8; however, b... | 114,299 | [
-0.1102805,
0.178599,
-0.4212707,
0.1561347,
-0.03677633,
0.0483341,
-0.2398231,
-0.2039077,
0.09752127,
-0.2324856,
0.09155688,
0.005812973,
0.1099285,
0.1504477,
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0.2659959,
-0.9905938,
0.300523,
-0.1773968,
0.209164,
0.4402492,
0.395633,
-0.08393187,
0.195... |
Dissociation of effects of nitroglycerin on regional refractoriness and regional myocardial blood flow following acute coronary occlusion. | Nitroglycerin is known to affect the electrophysiological properties of the ischaemic ventricle, possibly by altering regional myocardial blood flow. This study correlated the effects of nitroglycerin, given after acute coronary occlusion, on regional ventricular refractoriness and regional myocardial blood flow. Nitro... | 114,301 | [
0.08207209,
0.03023349,
-0.4242559,
-0.1484913,
0.03091594,
-0.2638626,
-0.01545398,
-0.3245264,
-0.06472693,
-0.1203752,
-0.05342,
-0.1313181,
-0.386848,
0.06518731,
-0.1495208,
-0.2771045,
-0.2830604,
0.201962,
-0.08476276,
0.1023805,
0.07963673,
-0.1419716,
0.09001198,... |
[Ultrastructure of gonadotropic cells of the normal eel and after estradiol injection]. | Male and female silver eels, in fresh water or sea water, have few gonadotrophs (GTH) poorly differentiated. An oestradiol (E2) treatment induces their development: a well developed Golgi area, abundant secretory granules (200-500 nm), dilated cisterna and large globules 1.2-2.2 micron) are observed. A positive feedbac... | 114,314 | [
-0.09703858,
0.07291088,
-0.1746857,
-0.1258969,
-0.01043519,
-0.1806554,
-0.099213,
-0.1600178,
-0.2169612,
0.1693665,
-0.1087733,
0.3850031,
-0.2226725,
0.01140913,
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-0.2654286,
0.2504201,
0.04835501,
0.01768428,
0.5919269,
0.253842,
-0.02703794,
... |
[Stereotype and plasticity of utterances in gibbons (Hylobates concolor leucogenys)]. | The "great call" of adult male and female Hylobates concolor leucogenys was studied in different conditions of social stimulation, using quantitative (i. e. sonographic) analysis. Vocal sequences are generally made up of mixed sounds, appearing in a fixed order and constituting a species-specific character. Qualitative... | 114,327 | [
0.3340805,
0.1974722,
0.01310189,
0.01469043,
0.2002421,
-0.4513255,
-0.2865401,
-0.399539,
0.2266777,
0.176551,
0.1362826,
0.02320221,
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0.1274149,
0.05702341,
0.4189353,
-0.04214904,
-0.0780099,
-0... |
The influence of bromocriptine on serum levels of growth hormone and other pituitary hormones and its metabolic effects in active acromegaly. | The effect of treatment with bromocriptine for 12--18 months on serum GH and metabolic responses was studied in sixteen patients with active acromegaly. Of this group ten patients showing a sustained GH reduction of more than 50% during an 8 h bromocriptine test, proved to be responsive to long-term therapy. In the res... | 114,344 | [
0.1461838,
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-0.2011325,
-0.3592745,
0.2442888,
-0.2566479,
0.1144072,
0.07362171,
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0.163395,
0.2284216,
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0.008639078,
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0.1108554,
-0.111718,
0.001803997,
0.255927,
0.1208857,
0.04559643,
-0... |
Effects of dietary cadmium on rhesus monkeys. | Ten male rhesus monkeys, each weighing 3.5 kg, were divided into four groups of 3, 3, 2, and 2, and were fed daily with 100 g pelleted food containing 300, 30, 3, and 0 ppm cadmium, respectively. Urine samples were collected every 2 weeks and blood samples every 4 weeks. One monkey each of the 300 and 30 ppm groups was... | 114,386 | [
0.07662822,
-0.1947447,
-0.3316991,
0.04595416,
0.1344219,
-0.4303852,
-0.1262217,
0.06680743,
0.1630936,
0.03571199,
0.1551478,
0.1137602,
0.2085865,
0.02914382,
-0.4324231,
0.3850929,
-0.2563255,
0.2292959,
-0.04185801,
0.3174325,
-0.2255819,
0.5518355,
-0.06967431,
-... |
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