title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Comparative studies of penicillin-binding proteins in Pseudomonas aeruginosa and Escherichia coli. | Penicillin-binding proteins in Pseudomonas aeruginosa were compared with those of Escherichia coli. These in P. aeruginosa were found exclusively in the cytoplasmic membrane fraction (fraction soluble in sodium N-lauroyl sarcosinate). Sodium dodecyl sulfate/acrylamide gel electrophoresis of the proteins bound to [14C]p... | 114,388 | [
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Purification and some characteristics of the human coagulation factor VII. | 1. A purification procedure for factor VII (proconvertin) from human plasma is described. The procedure involves barium sulphate adsorption and elution. DEAE-Sephadex column chromatography, barium sulphate adsorption and elution, heparin-Sepharose column chromatography, preparative disc gel electrophoresis and finally ... | 114,392 | [
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Pharmacokinetics of cyclophosphamide after prolonged low dose treatment in ovarian cancer patients. | We have studied Cyclophosphamide (Cy) pharmacokinetics in 9 patients after their first intravenous dose of 100 mg, and in 9 patients after 6--13 months of continual treatment with the same dose every day. The half-life of Cy was shorter (p less than 0.05) in the latter group, the Co was greater (less than 0.01) and the... | 114,397 | [
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Superoxide dismutase and life span of Drosophila melanogaster. | Comparison of superoxide dismutase activity in homogenates of wild and vestigial strains of D. melanogaster revealed a lower enzyme activity in the short-living vestigial strain. | 114,412 | [
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Is superoxide dismutase a physiological radioprotector? | Prolonged treatment with relatively low doses of ionizing radiation did not induce synthesis of superoxide dismutase, either in Drosophila melanogaster or in mice liver. | 114,413 | [
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Cell surface changes in mouse peritoneal macrophages after induction with proteose peptone or thioglycollate. | Some five to six per cent of mouse PEC spontaneously form rosettes with SRBC. This weak intercellular interaction is most likely mediated by a "receptor" for SRBC located on the surface of peritoneal macrophages. Manifestation of the receptor is influenced by the genetic background and the H-2 haplotype of PEC donors; ... | 114,430 | [
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Cost-benefit evaluations in primary health care. | Social work programs in primary health care (PHC) agencies have been well patronized and effective, but the expansion of social worker involvement in PHC depends on cost-benefit evaluations that satisfy the financial requirements of those who run PHC--the physicians. This article outlines a model for determining the co... | 114,461 | [
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[Parenteral feeding with varying amounts of nitrogen and calories in patients with esophageal carcinoma]. | Eighteen male patients with operable esophagus carcinoma received parenteral nutrition during 4 preoperative and 14 postoperative days in three different infusion regimens. It was possible to demonstrate that a preoperative positive N-balance can be achieved in all patients of each group in comparison to 2 of the 3 gro... | 114,479 | [
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Action of bacterial endotoxin and lipid A on mitochondrial enzyme activities of cells in culture and subcellular fractions. | Escherichia coli O127:B8 lipopolysaccharide (LPS), prepared by the Westphal procedure, caused a marked decrease in the activities of mitochondrial malate dehydrogenase, succinate dehydrogenase, and adenylate kinase in African green monkey kidney (Vero) cells and primary cultures of mouse liver cells within 2 h after ex... | 114,491 | [
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A high molecular weight DNA polymerase from Drosophila melanogaster embryos. Purification, structure, and partial characterization. | The DNA polymerase of early embryos of Drosophila melanogaster has been purified to near-homogeneity. The purified enzyme gave a single, catalytically active protein band after polyacrylamide gel electrophoresis, under nondenaturing conditions. Four polypeptides with molecular weights 43,000, 46,000, 58,000, and 148,00... | 114,515 | [
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Regulation and state of aggregation of Bacillus subtilis prephenate dehydratase in the presence of allosteric effectors. | Prephenate dehydratase from Bacillus subtilis was found to exist in three states of aggregation. A high molecular weight (210,000) species was fully active and the catalytic activity was unaffected by the effectors methionine or phenylalanine. Low concentrations of phenylalanine caused dissociation to a Mr = 55,000 dim... | 114,523 | [
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Echocardiographic aortic ejection area as a reflection of left ventricular stroke volume. | Systolic cusp separation of normal aortic valves has been shown by echocardiography and by angiography to be related to left ventricular stroke volume. In this study, stroke volume was compared with echocardiographic area between the aortic cusps in systole (aortic ejection area). An excellent correlation was observed ... | 114,543 | [
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The raphe nuclei of the rabbit brain stem. | The raphe nuclei of the rabbit brain stem were found in the midline and adjacent reticular formation of the medulla, pons, and mesencephalon. Nuclei raphe obscurus, pallidus, and magnus were located in the medulla. Nucleus raphe pontis and the caudal portion of nuclei raphe dorsalis and centralis superior were present ... | 114,552 | [
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The effect of TRH on the release of TSH, PRL and GH in man under basal conditions and following methysergide. | Pretreatment with methysergide, a blocker of serotoninergic receptors, significantly reduced the TSH response to TRH in six male volunteers. The TRH-induced PRL release was also slightly decreased, while plasma GH levels were not significantly modified by TRH either during the control period or after methysergide. Thes... | 114,568 | [
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The amyloidosis of juvenile rheumatoid arthritis - comparative studies in Polish and American children II. Serum immunoglobulins, kappa and lambda light chain and C3 levels. | The concentration of serum IgG, IgM, IgA, IgD, IgE and complement C3 as well as Kappa and Lambda free and bound light chains were determined in sera from 21 amyloidotic Polish children with juvenile rheumatoid arthritis (JRA), Polish and American children with JRA, and control children from a Polish population. Compara... | 114,636 | [
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Gold in the treatment of rheumatoid arthritis -- why, when and how? | The use of gold salts is reviewed and discussed in terms of rationale (Why), indications and side-effects compared to other disease suppressives (when), and different types of gold and their modes of administration (How). | 114,641 | [
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Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin. | Alcohol, ketone, aldehyde, and oxime analogues of ambruticin (1) were prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans, and Streptococcus pyogenes. Structure-activity relationships are described. Increasing the bulk of substituent at C1 and C5 reduces antifungal a... | 114,657 | [
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5-[(4-Methyl-1,2,3,4-tetrahydroquinoxalyl)methyl]-2'-deoxyuridine 5'-phosphate: an analogue of a proposed intermediate in thymidylate synthetase catalysis. | In a study of the sequence steps involved in the mechanism of thymidylate synthetase catalysis, 5-[(N-methyl-piperazinyl)methyl]- (5) and 5-[(4-methyl-1,2,3,4-tetrahydroquinoxalyl)methyl]-2'-deoxyuridine 5'-phosphate (6) were synthesized. Compound 6 has high affinity for the Lactobacillus casei enzyme (Ki = 0.75 microM... | 114,659 | [
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[Pseudodiverticulosis of the esophagus (author's transl)]. | The autopsy of a 59 years old male incidently revealed a pseudodiverticulosis of the esophagus. Histologic examination demonstrated typical cystic ectasies of all glandular ducts in the esophagus; they appeared on radiologic examination and are visible at endoscopy as little yellowish cystic lesions. The disease usuall... | 114,742 | [
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[Treatment of primary chronic polyarthritis with ranoroc (author's transl)]. | In the framework of a clinical study the butazone derivative Ranoroc was tested for efficacy and tolerance in 50 patients with primary chronic polyarthritis. The success rates both in previously treated and untreated patients were approximately equal, i. e. 92%. In the previously treated group, a superior effect of Ran... | 114,776 | [
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[Total hip prosthesis and sport (author's transl)]. | The artificial replacement of the hip joint has become a routine operation the assessment of load resistance of the total hip prothesis (THP), on the other hand, is very variable. If at all possible, a THP should only be implanted in elderly people usually with the object of obtaining painless and improved walking abil... | 114,799 | [
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[Victimology of sexual crime. Examination of victims and the consequences for behavior, prophylaxis and therapy (author's transl)]. | Medico-legal and criminological examinations of 93 sexual crimes are reported. This figure comprises all the crimes which have become known to the police during a certain period in one region. It is suggested that the medical examination by confined to specific wards of the gynecological hospital so that psychological ... | 114,808 | [
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Small area estimation--synthetic and other procedures, 1968-1978. | Methods for obtaining small area estimates which have emerged over the past decade are reviewed with particular emphasis given to synthetic estimation, a procedure originally developed at the National Center for Health Statistics which has found wide acceptance because of its simplicity and intuitive appeal, and yet ha... | 114,853 | [
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Deciphering deinstitutionalization: complexities in policy and program analysis. | Deinstitutionalization as a public policy promised to be a major departure from previous psychiatric practice. Decrying traditional "medical paradigms" and the custodial "warehousing" of mental patients, policy makers advanced a "bold new approach" for care in the community. Progressive humanitarian reform could go han... | 114,875 | [
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A new method for determining impulsive time constants and their application to clinical data. | We have developed an accurate, convenient method for determining unique values of vestibular time constants from impulsive tests. The method was used to determine the mean values and standard deviations of 36 normal subjects. A comparison between these normal values and data from patients with cerebellopontine (CP) ang... | 114,925 | [
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An alternative approach to the pterygopalatine fossa by removing the mandible and immediately replacing it. | A case is presented with a child with a desmoid tumor of the pterygopalatine fossa in which approximately a third of the mandible including the condyle was removed for exposure. The trimmed mandibular segment was then returned to position with a fascia cap over the condyle and intermaxillary fixation was instituted. Th... | 114,936 | [
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Memory disorder in vertebrobasilar disease. | Previous workers have clearly established that the central core limbic structures of the brain are primarily concerned in the production of amnesia of the axial or mesial type. The blood supply to these structures derives primarily from the posterior cerebral circulation. This was the rationale for Benson's work on 'am... | 114,997 | [
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Chromosomal location of the genes for human immunoglobulin heavy chains. | We have studied somatic cell hybrids between P3x63Ag8 mouse myeloma cells deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and either human peripheral lymphocytes or human lymphoblastoid or myeloma cells for the production of human immunoglobulin chains and for the expression of enzyme markers assigned ... | 114,999 | [
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-0.007406632,
0.1810687,
0.3071988,
0.3559198,
-0.09995022,
... |
Comparison of mRNA precursors in plasmacytomas producing closely related kappa chains. | To help elucidate the mechanisms of formation and expression of active immunoglobulin genes, we have made a systematic study of the processing patterns of the mRNAs that code for a closely related family of kappa chains. Among the members of this family, represented by the V(kappa)21 group of plasmacytomas, are example... | 115,006 | [
-0.4209221,
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0.... |
Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway. | Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the meta... | 115,007 | [
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0.1775426,
0.3891087,
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0.2510591,
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... |
Ethanol drinking by rhesus monkeys with concurrent access to water. | Three monkeys were provided concurrent access to water and ethanol in concentrations of either 8, 16 or 32% (w/v) during daily 3-hr sessions. The monkeys were those for whom ethanol had been established as a reinforcer in an earlier study in which only ethanol or water was available. Ethanol was preferred to water at a... | 115,013 | [
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0.1004011,
0.2880975,
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-0.1024052,
-0... |
[Neuroendocrinological changes under longterm therapy with lithium salts (author's transl)]. | 15 patients with formerly endogenous recurrent depression or manic-depressive illness free of psychotic symptoms, who are under lithium prophylaxis about 3,9 years, and 16 healthy controls with approximately the same age and sex were tested with 0,1 U Insulin/kg, 200 micrograms TRH and 50 micrograms LHRH for their hGH-... | 115,022 | [
0.03220705,
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0.1540689,
0.3110442,
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0.2746147,
0.3353069,
0.1143212,
-0.2485002,
... |
Modification of the behavioural effects of amphetamine by a GABA agonist in a primate species. | Acute administration of d-amphetamine in the marmoset results in a dose dependent increase in small head movements (checking), and an almost total suppression of purposeful activities and social interaction. It has little effect on locomotion and does not induce stereotyped gnawing. The GABA-agonist, muscimol, decrease... | 115,041 | [
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0.293217,
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0.3061666,
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0.188168,
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0.1256904,
-0.1629789,
0.1610623,
-0.2489848,
-0.042753,
0.1578011,
-0.07... |
An associative analysis of pretreatment effects in gustatory conditioning by amphetamine. | Various attempts have been made to account for the fact that pertreatment with some pharmacological agents reduces the ability of such agents to induce conditioned aversion to a flavor. One explanation, based on the concept of tolerance, suggests that pretreatment is effective because it renders the animal less sensiti... | 115,042 | [
-0.04843442,
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0.2095,
0.1020632,
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0.1275253,
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0.08091816,
-0.09276559,
-0.3109294,
0.12452... |
Electron-beam arc therapy using a high energy betatron. | Dose distributions in electron-beam arc therapy were investigated using the electron beam from a Brown Boveri 45 MeV betatron. This variable isocenter machine is equipped with an angular speed control device that synchronizes the radiation dose rate with the rotation speed about the isocenter. An Alderson Rando phantom... | 115,060 | [
-0.3084004,
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0.1177175,
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0.02291332,
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0.3820842,
0.1090429,
0.1392371,... |
[The effectiveness of the drugs Dovenix and Bilevon(R)-Injection against liver fascioliasis (Fasciola hepatica, Linné 1758) in cattle]. | Dovenix and Bilevon-injection (manufactured by SPECIA, France and BAYER, West Germany, respectively) were tested for their anthelmintic efficacy against Fasciola hepatica in cattle. The drugs proved highly effective against both adult and immature flukes. The faeces of the treated animals were negative for F. hepatica ... | 115,128 | [
0.1309699,
0.08680476,
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0.196089,
0.1291111,
0.2364231,
0.06120601,
0.3390401,
-0.2484177,
0.29947... |
[The effect of feeding rumen contents on glutamate dehydrogenase activity in some organs of broilers]. | The effect of the replacement of 50, 60 and 80% of proteins in diet by dried rumen contents on glutamate dehydrogeanse activity (EC 1.4.1.3) in the kidneys, liver, and caecum tissue and contents was studied in broilers. The liver and caecum tissue did not show any significant changes in the activity of glutamate dehydr... | 115,134 | [
-0.08510505,
0.0159777,
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0.05632218,
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0.04581914,
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-0.6797211,
0.1350636,
0.2601133,
0.3446734,
0.3786736,
0.4893659,
0.00987018... |
Complement components detected on normal red blood cells taken into EDTA and CPD. | Normal red blood cells (RBC) from fresh EDTA and CPD blood and from stored CPD blood were examined for the presence of bound subcomponents of C3 and C4. By serologic agglutination tests, only C3d was detectable on the cells. Incubation in compatible fresh normal serum (FNS) at 37 degrees C appeared to increase the amou... | 115,154 | [
-0.03833578,
0.06123383,
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0.07687738,
0.3848087,
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0.1131329,
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-0.04846734,
-0.09626979,
0.4167517,
0.122257,
0.31958,
-0.1808746,
-0.19... |
The Duffy blood group system in Israeli Jews and Arabs. | The distribution of the Fy gene was studied in 1,207 Israeli Jews and 509 Arabs. The Fy(a--b--) phenotype (FyFy) was observed in Moslem, Christian and Druze Arabs, and in Jewish immigrants from Yemen and Iraq, but not in Sephardi or Ashkenazi Jews. The Fy gene frequencies in Arabs and Jews were compatible with historic... | 115,155 | [
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0.1366623,
0.2282432,
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0.2803987,
-0.03229329,
0.6874965,
0.06330401,
-0.25926... |
Developmental-related changes in the lectin binding to cells of the central nervous system. | Developmental related changes in Concanavalin A binding to nerve tissue are reported in this paper. ConA binding sites were studied in brains of rats and chicks at different embryological stages using the ConA-Peroxidase-DAB sequence. Developmental related changes in the extent, and pattern of ConA binding sites were o... | 115,213 | [
0.286778,
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0.192957,
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0.2786479,
0.2628675,
-0.1592944,
0.2083235,
0.3768224,
0.02457697,
-0.01... |
Detection of iodine, sulphur and phosphorus in histological thyroid sections by using electron probe microanalysis. | Electron probe microanalysis for iodine, sulphur and phosphorus was performed in histological frozen sections from thyroid tissue of 5 patients undergone thyroid surgery for benign disease. Iodine seemed to be localized in the colloid of the thyroid follicles. Phosphorus localized in areas which corresponded with the e... | 115,215 | [
-0.1925514,
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0.122405,
0.412602,
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0.02005143,
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0.006055829,
0.3197583,
0.0645473,
-0.03327392,
... |
The histochemical demonstration of guanase: observations in the human central nervous system. | 1. A method is described for the histochemical demonstration of the purine catabolizing enzyme guanase, employing glutaraldehyde fixation and Nitro blue tetrazolium (NBT). Parallel biochemical studies confirm that enzyme activity is not significantly inhibited by exposure to glutaraldehyde. 2. By this procedure guanase... | 115,216 | [
0.1770552,
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0.2676378,
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0.4297215,
0.07797704,
0.4393347,
0.02416676,
0.... |
Cost-benefit analysis of posterior fusion of the lumbosacral spine. | In this study the cost-benefit ratio of posterior fusion of the lumbosacral spine was assessed. The calculations were based on 118 operated patients, followed up for an average of 4.8 years. Costs were calculated using the average costs of treatment at central hospitals, visits to the outpatient department and travelli... | 115,220 | [
-0.09848088,
0.2824071,
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0.07660738,
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0.01959388,
0.2198371,
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0.1185472,
0.2307679,
0.4020915,
0.046... |
How do kinins affect vascular tone? | Because kinins affect vascular tone, it is assumed that kinins act directly on smooth muscle. However, a direct interaction is difficult to conceive. Vessels containing smooth muscle are lined by a continuous endothelium with tight junctions. In addition, kinins act on endothelial cells to cause the release of prostagl... | 115,238 | [
-0.2495447,
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0.2329257,
0.05113483,
0.1264651,
0.3376516,
0.1704626,
-0.06691325,
... |
Relation between ulcerogenic activity of various NSAID and their potency as inhibitors of prostaglandin synthesis in vivo. | A series of non-steroidal anti-inflammatory drugs (NSAID) and a few other agents were evaluated for their ability to: 1) reduce the acute toxicity of intravenously injected arachidonic acid (AA) in mice; 2) prevent castor oil-induced diarrhoea in mice; 3) enhance the formation of gastric mucosal erosions by a water str... | 115,259 | [
-0.4720163,
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0.08898492,
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0.4258657,
0.007450981,
-0.254903,
-0.136195,
... |
Correlation between lymphographic grouping and anatomic and clinical stages in chronic lymphoid leukemia. | In a retrospective study of lymphograms in 55 patients with chronic lymphatic leukemia observed 42-170 months, four lymphographic groups were established according to lymph node size and morphology. In group 1, the lymph nodes were only slightly enlarged and pathologic in appearance. In group 2, the nodes were moderate... | 115,263 | [
0.1244936,
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0.3401545,
0.2264883,
0.3210831,
0.1869887,
-0.1018561,
0.43... |
Pancreatic pseudocysts of the duodenum. | A pancreatic pseudocyst within the wall of the duodenum is presented. Its radiographic features were analyzed and comprehensively compared with 10 proved cases. These pseudocysts can be intramural or extrinsic severely compressive lesions. The occurrence of these pseudocysts at multiple sites throughout the gastrointes... | 115,268 | [
-0.1621371,
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0.08738617,
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0.09378856,
-0.06962959,
-0.04139... |
Evaluation of 111In leukocyte whole body scanning. | Indium-111 oxine, polymorphonuclear cells isolated and labeled with 111In were used for studying absecesses and inflammatory conditions. There were 64 total scans done in 59 patients, 32 male and 27 female, aged 3-81 years (average, 51). The original clinical diagnosis was abscess in 33 patients. The whole blood cell s... | 115,272 | [
-0.3083819,
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0.08232762,
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0.01353689,
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0.3046039,
0.1563981,
0.2058272,
-0.3088267,
... |
Percutaneous ureteral stent placement for stricture management and internal urinary drainage. | Percutaneous ureteral stent placement was attempted in nine patients with 14 ureteral lesions. Eight strictures in six patients were successfully stented. Three were subsequently converted to indwelling ureteral stents. The technique is described. No significant complications occurred. The procedure should be attempted... | 115,275 | [
-0.2477803,
0.03500666,
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0.004299818,
0.008358506,
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0.08632082,
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0.1873538,
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-0.5722532,
0.01286897,
-0.06198696,
-0.024... |
Evaluation of glenoid labrum by double-contrast shoulder arthrography. | Double-contrast shoulder arthrography was used to define the normal and abnormal arthrographic anatomy of the glenoid labrum. A retrospective study of 12 patients suspected of having labral abnormalities or who had unexplained shoulder disability consistent with capsular laxity was undertaken. In four of the nine patie... | 115,277 | [
-0.03950508,
0.1529505,
0.07625016,
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0.2970406,
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0.133167,
0.1705717,
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0.2984615,
0.08738407,
-0.1439348,
... |
The mucopolysaccaridoses: clinical and biochemical correlations. | The mucopolysaccharidoses (MPS) are hereditary diseases that result in deformities related to connective tissues. Some types of MPS lead to progressive mental retardation. Biochemically, these syndromes are characterized by excessive accumulation and excretion of various types of glycosaminoglycans (mucopolysaccharides... | 115,315 | [
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-0.05780644,
0.3300278,
0.02938146,
0.0002511182,
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0.3220128,
0.2677745,
0.08264321,
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-0.1149673,
0.3444754,
-0.05870701,
0.2111374,
0.1595774,
-0.18114... |
[Anesthsiological experiences in experimental surgery]. | The paper reports experience with methods of anaesthesia in rabbits, rats, mice, guinea-pigs, pigs, sheep, baboons, dogs and cats. Special problems of handling, mode of injection and intubation are discussed. A comprehensive survey of literature provides further information about the proposed patterns of anaesthesia an... | 115,325 | [
-0.0721325,
-0.007355746,
-0.3041341,
-0.1713614,
0.1711187,
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0.2303935,
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0.1014947,
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0.008175132,
-0.4335526,
0.2348633,
0.0198929,
0.1976246,
0.1335859,
0.07113599,
0.009888275... |
[Diagnosis of post-operative jaundice (author's transl)]. | The typical factors responsible for post operative jaundice are: 1) increased pigment load; 2) hypoperfusion; 3) sepsis and 4) drugs. In the patient evaluation, one should carefully review the patients chart for hypotensive episode during surgery, the drugs being administerd and the evolution of the illness which will ... | 115,338 | [
0.1680238,
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-0.1182757,
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0.3995379,
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0.3495667,
0.5079819,
0.1251218,
0.3205322,
-0.1158564,
-0.2511639,
... |
[The management of mediastinal infection following cardiac surgery. Role of the reanimation and of hyperalimentation (author's transl)]. | Apprehended complication of the cardiac surgery by median sternotomy, the mediastinitis leads very often to a high death rate, a long hospital-treatment, frequent and sometimes serious sequelae. Considering eleven cases, we are trying to show the interest brought by the choice of the immediate thorax-closing method, in... | 115,339 | [
-0.3815543,
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-0.3745132,
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0.2728523,
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-0.02567168,
-0.06256731,
-0.2374654,
0.03584534,
0.2072152,
-0.06087... |
[Pharmacology of nitroglycerin (author's transl)]. | Nitroglycerin is a vasodilating agent by virtue of its actions on vascular smooth muscle fibers. It may be administered intravenously (using either 5 p. cent dextrose, or propylene-glycol solvant), sublingually, orally or by topical administration. It is rapidly metabolized, principally by liver. Its is not toxic. The ... | 115,340 | [
-0.1423233,
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0.1124461,
0.4366745,
0.1296354,
-0.03793307,
0.01722195,
-0... |
Conductive hearing loss effects on children's language and scholastic skills. A review of the literature. | A review of available studies investigating the consequences of conductive hearing loss for language acquisition and scholastic performance was carried out. It uncovered no study that met the standards of rigor needed to provide a definitive answer to this question, although the burden of the evidence is that a persist... | 115,361 | [
-0.02632284,
0.03202413,
0.5555433,
0.03424742,
-0.07846522,
-0.2697133,
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-0.08975865,
0.1149314,
0.2861874,
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0.2206922,
-0.5604261,
-0.2310168,
-0.1747359,
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0.0006208449,
0.1734631,
-0.3884803,
-0.1967377,
0.2682252,
0.0420251,
0.01978794,... |
Otitis media and child development. Design factors in the identification and assessment of hearing loss. | Otitis media with effusion (OME) is the major cause of auditory dysfunction in preschool and early-grade schoolchildren. At especially high risk are children with cleft palate/lip; some groups of mentally retarded children; children from underprivileged communities and children with severe or profound sensorineural hea... | 115,360 | [
-0.05555022,
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0.06510261,
... |
[Risks and median-term results of aortic valve replacement for calcifying aortic stenosis in 100 patients more than 70 years old]. | 100 patients with poorly tolerated calcific aortic stenosis underwent aortic valve replacement by the same surgical team (Starr-Edwards prosthesis: 52 cases, Bjäork prosthesis: 43 cases, Lillehei-Kaster prosthesis: 2 cases, and Hancock bioprosthesis: 3 cases) between July 1971 and April 1978. The hospital mortality was... | 115,427 | [
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... |
[Lymphangioendothelioma. A rare cause of atrioventricular block]. | A new case of lymphangio-endothelioma of the nodal tissue is reported. Complete atrioventricular block had been followed up for 20 years. The histological features are described in detail and the embryological origins of the tumour are discussed. This report underlines the exceptional character of this "smallest benign... | 115,436 | [
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0... |
Suprathreshold retinal damage due to single 6 picosecond 1060 nm laser light pulses. | The retinas of rhesus monkeys were exposed to 6 ps laser light pulses at 1060 nm at 62 and 95 muJ. Lesions were examined by light and transmission and scanning electron microscopy. Evidence of damage was seen in all retinal layers, being most severe in the photoreceptor inner and outer segments. In addition to damage m... | 115,454 | [
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-... |
Oviposition site preference in Drosophila. | Comparative studies of oviposition site preference (OSP) in Drosophila suggest that choice of oviposition site is an important adaptive behavior which influences individual fitness and the potential of populations for speciation. OSP has been investigated under conditions which provided females with a choice of standar... | 115,458 | [
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... |
Studies on the mechanism of hepatic microsomal N-oxide formation. N-oxidation of NN-dimethylaniline by a reconstituted rabbit liver microsomal cytochrome P-448 enzyme system. | The N-oxidation of NN-dimethylaniline was studied by using a reconstituted rabbit liver microsomal enzyme system consisting of highly purified cytochrome P-448, NADPH-cytochrome c reductase and lipid factor. Both cytochrome P-448 and NADPH-cytochrome c reductase were required for optimum N-oxygenating activity; the cat... | 115,464 | [
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... |
Influence of anticoagulant substances on phosphoserine and taurine of human blood. | The influence of heparine (Liquemin) and sodium-EDTA on phosphoserine and taurine of human blood was investigated. Phosphoserine which was not or nearly not present in serum increased after addition of both the anticoagulant substances. The heparine used contained phosphoserine as the only ninhydrinic substance in low ... | 115,479 | [
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Treatment settings in psychiatry: long-term family and social findings. | Treatment in a psychiatric unit, as distinct from a psychiatric hospital, held no benefits in the long term (5-8 years after admission) as far as the patient's mental and behavioural status and employment, or the family's burdens, health needs or attitude were concerned. Schizophrenic patients from both settings receiv... | 115,534 | [
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0.4226553,
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Effect of ethane-1-hydroxy-1,1-diphosphonate and vitamin D on bone mineralization. | Administration of large quantities of ethane-1-hydroxy-1,1-diphosphonate to growing chicks resulted in a decrease in percent bone ash and an increase in percent osteoid. The degree of inhibition of bone mineral accumulation was a function of both duration and quantity of ethane-1-hydroxy-1,1-diphosphonic acid administr... | 115,555 | [
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... |
Depressed PHA transformation and acute leukemia in macroglobulinemia. | Two out of fifty-three patients with macroglobulinemia developed acute leukemia following chemotherapy. The Phytohemagglutinin (PHA) Transformation Index performed prior to the appearance of acute leukemia was found to be markedly depressed in these two patients in comparison with ten other patients with macroglobuline... | 115,573 | [
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Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents. | The immunodeficient state associated with adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency may result from the selective phosphorylation by thymus-derived lymphocytes of the ADA substrate deoxyadenosine and the PNP substrate deoxyguanosine, leading to the intracellular trapping of toxic de... | 115,660 | [
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... |
Recording small sharp spikes with depth electroencephalography. | Two patients with intractable seizures and focal temporal sharp waves also had small sharp spikes as incidental findings in their scalp electroencephalograms. Depth electroencephalography verified the intracerebral origin of the small sharp spikes and differentiated them from the more significant epileptiform abnormali... | 115,674 | [
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0.035... |
A translocation X;Y system for detecting meiotic nondisjunction and chromosome breakage in males of Drosophila melanogaster. | A nondisjunction and chromosome breakage screening system devised by Craymer and modified in our laboratory, involves an X;Y translocation with the short arm of the Y (Ys), marked with the wild type allele of yellow, attached to the distal end of an X (break point 11D) carrying the recessive marker y; and the long arm ... | 115,682 | [
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Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification. | 1. Human mesenteric lymph chylomicrons were isolated from chylous ascites fluid by ultra-centrifugation and agarose/gel chromatography and their apoprotein composition was analysed by dodecylsulfate/polyacrylamide gel electrophoresis, analytical isoelectric focusing and immuno-chemically. Major components of mesenteric... | 115,688 | [
-0.003292466,
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0.002744795,
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0.1753815,
-0.01027... |
Idiotypic cross-reactivity of human and murine phosphorylcholine-binding immunoglobulins. | The idiotypic cross-reactivity of mouse and human monoclonal immunoglobulins with binding activity for phosphorylcholine (PC) was investigated, using an idiotypic antibody elicited against the PC-binding human IgMFR. The isolated FR heavy chain proved to be a better inhibitor for the reaction of IgMFR with anti-FR than... | 115,695 | [
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-0.1497427,
0.05497... |
[Fistula-free method of evaluating cholagogue agents on rats]. | A new fistula-free method for standardizing and studying the choleretic activity of drugs on white rats is proposed. In rats under ether-urethane anestheia, a "biological test tube" of varied length where the bile is excreted, is created by ligation of the duodenum above and below the site of communication with the bil... | 115,710 | [
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0.1003897,
0.18... |
The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. I. Characterization of deficiencies and mapping of ADH and visible mutations. | The position of the structural gene coding for alcohol dehydrogenase (ADH) in Drosophila melanogaster has been shown to be within polytene chromosome bands 35B1 and 35B3, most probably within 35B2. The genetic and cytological properties of twelve deficiencies in polytene chromosome region 34--35 have been characterized... | 115,743 | [
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0.650728,
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... |
Protection against group B meningococcal disease: evaluation of serotype 2 protein vaccines in a mouse bacteremia model. | A mouse bacteremia model was used to evaluate the immunogenicity and protection against challenge provided by five different meningococcal serotype 2 vaccines. Mice vaccinated with serotype 2 protein vaccines had levels of bacteremia reduced by at least 100-fold after challenge with group B serotype 2 miningococci. Mic... | 115,794 | [
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0.1402288,
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0.4193739,
0.3360315,
-0.02880081,
0.0296879... |
Passage of Pseudomonas aeruginosa in compromised mice. | There was no appreciable increase in the virulence of Pseudomonas aeruginosa PAO-1 after six passes through infections in mice. When strain PAO-1 was passed through mice compromised with iron and methotrexate, the virulence of the passed bacteria increased for normal as well as compromised mice. Bacteria harvested from... | 115,795 | [
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0.2872691,
-0.008243688,
0.2976855,
0.0240984... |
Gamma-irradiated scrub typhus immunogens: broad-spectrum immunity with combinations of rickettsial strains. | Scrub typhus immunogens were prepared from Rickettsia tsutsugamushi strains Karp, Kato, Gilliam, Kostival, and Buie by exposing frozen infected yolk sac suspensions to 300 krad of gamma radiation. Mouse protection tests showed that each of the irradiated immunogens protected C3H/HeDub mice against high challenge levels... | 115,796 | [
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0.4326852,
0.1967509,
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0.... |
Developmental induction of Myxococcus xanthus myxospores. | Myxospore differentiation during the developmental cycle of Myxococcus xanthus is characterized by several distinguishable morphological stages. Two experimentally useful criteria of myxospore induction are the conversion of vegetative rods to optically refractile short rods or ovoids and the development of resistance ... | 115,838 | [
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0.1245107,
-0.1425376... |
Transfer ribonucleic acid synthesis during sporulation and spore outgrowth in Bacillus subtilis studied by two-dimensional polyacrylamide gel electrophoresis. | The synthesis of transfer ribonucleic acid (tRNA) was examined during spore formation and spore outgrowth in Bacillus subtilis by two-dimensional polyacrylamide gel electrophoresis of in vivo 32P-labeled RNA. The two-dimensional gel system separated the B. subtilis tRNA's into 32 well-resolved spots, with the relative ... | 115,846 | [
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... |
Organization of transfer and ribosomal ribonucleic acid genes in Bacillus subtilis. | The structural relationship between the transfer ribonucleic acid (tRNA) and the ribosomal RNA (rRNA) genes of Bacillus subtilis has been studied by restriction endonuclease analysis of total chromosomal deoxyribonucleic acid (DNA) and characterization of DNA fragments cloned in Escherichia coli. The DNA sequences enco... | 115,849 | [
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0.5163859,
0.1079336,
-0.07400... |
Methods for sequencing oligoribonucleotides and RNA by high performance liquid chromatography. | Conditions were established for the separation and quantitative determination of ribonucleosides, mono- and oligo-ribonucleotides by high-performance liquid chromatography (HPLC) on columns of AS-Pellionex SAX and AL-Pellionex WAX. By combining a high-speed UV spectrum monitor with an HPLC apparatus, products of RNase ... | 115,851 | [
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0.7940822,
0.01321412,
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0.... |
The complete amino acid sequence of the beta-subunit of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa. | The complete amono aicd sequence of the beta-subunit of protocatechuate 3,4-dioxygenase is presented. The beta-subunit contained 237 amino acid residues, 4 of which were methionines. Accordingly, cyanogen bromide cleavage of the S-carboxymethylated beta-subunit produced five peptides. The sequences of these peptides we... | 115,853 | [
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0.2717972,
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0.029... |
The primer tRNA for Moloney murine leukemia virus DNA synthesis. Nucleotide sequence and aminoacylation of tRNAPro. | The nucleotide sequence of a tRNA primer molecule for initiation of Moloney murine leukemia virus DNA synthesis has been determined. The sequence is heterogeneous in two positions but both forms, when drawn in a cloverleaf structure, have anticodon specificities for proline. We have termed these isoacceptors tRNA1Pro a... | 115,865 | [
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0.3398294,
0.1900685,
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0.... |
Characteristics of Pseudomonas aeruginosa in relation to laboratory-induced resistance to gentamicin. | Pseudomonas aeruginosa strain C2 was habituated to gentamicin by serial passage in broth containing increasing concentrations of the antibiotic and up to 250 microgram/ml. The resistant progenies differed from the parent strain in antibiotic susceptibility to two other aminoglycosides, colonial morphology, lytic phage ... | 115,904 | [
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0.04991768,
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0.08713817,
0.3125544,
0.04522829,
-0.03389817,
-0.131873,
-0.08150195,
... |
Commissural projections of the cortical hand motor area in monkeys. | The topographical organization of the contralateral cortical projections of the motor hand area was studied with autoradiographic methods in 11 macaque monkeys. Two general observations were noted in the material studied. (1) The commissural cortico-cortical connections of the motor hand area were directed to the contr... | 115,906 | [
-0.1532234,
0.1666954,
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0.1135135,
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0.1413184,
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0.1769534,
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0.4369686,
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0.07531671,
0.2576068,
0.1600344,
... |
Macrophages in resistance to rickettsial infection: macrophage activation in vitro for killing of Rickettsia tsutsugamushi. | Rickettsia tsutsugamushi, strain Gilliam, replicates in cultures of resident peritoneal macrophages from BALB/c mice. Macrophage cultures treated with culture supernatants of spleen cells from rickettsial-infected mice stimulated with heat-killed rickettsiae markedly suppressed macrophage infection by rickettsiae. Rick... | 115,917 | [
-0.2177855,
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0.1433741,
0.1040608,
0.04356918,
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0.05191008,
0.04697461,
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0.003280144,
-0.09621442,
-0.2440352,
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-0.4329184,
-0.03792812,
-0.1237938,
0.4089685,
0.02963595,
-0.1245132,
0.0648... |
Immunohistological staining of antigens on semithin sections of specimens embedded in plastic (GMA-Quetol 523). | Glycol methacrylate-Quetol 523, introduced by Kushida (1977) for combined light and electronmicroscopy studies at low magnification, also permits application of immunofluorescence methods to semithin sections. To recover the antigenicity of proteins fixed with formaldehyde, abrupt dehydration before embedding and subse... | 115,925 | [
0.3168385,
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0.1175827,
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0.04455265,
0.1586202,
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0.1534142,
0.3674684,
0.2194851,
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-0.2451104,
0.2663498,
0.2162074,
0.1296291,
-0.4071243,
0.15... |
Protein synthesis in Bunyamwera virus-infected cells. | In Vero cells infected with Bunyamwera virus there is a rapid inhibition of cell RNA and protein synthesis to levels of 30 and 3% respectively of the control rate, both the rate of inhibition and the time lag before its initiation being multiplicity dependent. Using u.v.-irradiated virus, investigation of the mechanism... | 115,963 | [
-0.1455342,
0.01134644,
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0.3794138,
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0.1485147,
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0.2798284,
0.097156,
-0.2306864,
... |
Luxotonic responses of units in macaque striate cortex. | 1. Single units in striate cortex were studied in alert macaques while they viewed a ganzfeld. Of the 385 well-isolated units studied for 10 min to 2 h, 24% gave "luxotonic" responses, i.e., their rate of discharge for 1 min or more in diffuse, featureless, wideangle illumination (20-450 cd/m2) was at least double that... | 115,968 | [
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0.04829431,
0.1390054,
0.04978005,
0.2419182,
0.04625859,
0.06629415,
... |
The effect on bone repair of aspirin cones placed in extraction sockets in dogs: a histopathologic study. | Four canines of eight 2-year-old dogs were extracted surgically, a mucoperiosteal flap being raised. A standardized pair of the post-extraction cavities were filled with three aspirin cones, the other pair being used as controls. The flaps were sutured with surgical gut. The dogs were killed at intervals of 2, 4, 6 and... | 115,978 | [
-0.0356571,
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0.2010914,
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0.1728189,
-0.04096118,
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0.1754088,
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0.1766254,
0.09183819,
0.3553798,
-0.1798673,
0.2843599,
-0.1031338,
... |
An X-ray cephalometric analysis of premaxillary growth in operated and unoperated baboons (Papio cynocephalus). | Rates of growth of the premaxilla in baboons, which have undergone removal of the nasal septum, and unoperated controls are compared using X-ray cephalometric analysis and direct measures. It is found that our X-ray analysis without the use of metallic implants is not sensitive enough to detect changes of growth rate w... | 116,005 | [
0.1307303,
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0.07106002,
0.1345183,
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0.1206617,
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0.2535613,
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0.4658716,
-0.1519677,
0.1573494,
... |
Deranged isoleucine metabolism during ketotic attacks in patients with methylmalonic acidaemia. | Two patients with methylmalonic acidaemia due to methylmalonyl-CoA mutase deficiency were studied for several years. Both exhibited at least two attacks of severe ketoacidosis, during which they excreted, in addition to methylmalonic acid, a number of abnormal compounds: 3-hydroxypropionic acid, 2-methyl-3-hydroxybutyr... | 116,077 | [
-0.3597896,
-0.05858933,
-0.04315986,
-0.3092214,
0.1810028,
-0.02750286,
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-0.02179723,
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0.09171151,
0.2841441,
0.5210586,
-0.1172633,
-0.2447611,
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0.2444823,
-0.594548,
0.2998021,
-0.125603,
-0.002491337,
0.1993649,
0.4180115,
0.1071447,... |
Paranasal sinus aspergillosis. | Four cases of aspergillosis of the paranasal sinuses seen recently at the North Carolina Baptist Hospital are reported. Paranasal sinus aspergillosis is prone to develop in patients living in the southeastern states because those states 1. have an agricultural economy and 2. have a hot, humid climate that causes a high... | 116,100 | [
-0.1444992,
-0.3072872,
0.06443305,
0.02350857,
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0.1428323,
0.4742616,
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0.01149071,
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0.4092137,
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0.1319457,
0.3052929,
-0.24918,
0.1701727,
0.2613654,
-0.1113785,
0.... |
Primary Ewing's sarcoma of the sternum: a case report. | A 12 1/2-year-old female presented with Ewing's sarcoma of the manubrium sterni which extended into the anterior mediastinum. At presentation there was no evidence of metastatic disease. Her initial treatment consisted of radiation therapy and chemotherapy. The residual tumor was subsequently resected and the sternal d... | 116,117 | [
-0.2526438,
0.4344322,
-0.02511269,
-0.01277524,
-0.2050335,
-0.357463,
-0.2938401,
0.06789308,
0.1069227,
-0.1831456,
0.2904335,
0.106687,
0.1075494,
0.2089408,
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-0.4557494,
-0.08536963,
-0.05802058,
-0.1594618,
0.3458979,
0.1480621,
-0.04801632,
... |
Inhibitory effect of cystic fibrosis serum on pseudomonas phagocytosis by rabbit and human alveolar macrophages. | This report presents experimental observations indicating the presence of an inhibitory activity in cystic fibrosis (CF) serum which impairs phagocytosis of Pseudomonas aeruginosa by rabbit as well as human alveolar macrophages. Of the 49 patient serum samples studied, 40 consistently showed greater than or equal to 60... | 116,188 | [
-0.03579034,
0.04118489,
-0.118186,
-0.06145998,
0.01054192,
0.1007224,
-0.1883054,
0.01794028,
0.1130804,
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0.04524203,
0.4148101,
-0.09674162,
-0.1878191,
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-0.5198602,
-0.2616334,
-0.07316526,
0.3884558,
-0.001479647,
0.2943273,
-0.20407... |
Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. | To investigate the organization of immunoglobulin genes, we have constructed a clone library containing 10(6) randomly generated fragments of mouse embryo DNA, corresponding to eight equivalents of the genome. The cloning method involved methylation of embryo DNA at EcoRI recognition sites, partial digestion by EcoRI* ... | 116,236 | [
0.01481566,
0.1524404,
-0.3657142,
0.0005679605,
0.3789398,
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-0.2465607,
0.03561368,
0.1458979,
0.3779396,
0.03604099,
0.161251,
0.1300946,
0.2103521,
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0.2116923,
-0.3556748,
0.1707812,
0.08223297,
-0.1232135,
0.3065125,
-0.07934988,
-0.2332648,
-0... |
Effects of an enkephalin analog on complex learning in the rhesus monkey. | Facilitation of the learning of a discrimination reversal task for a reward of food was found in rhesus monkeys after subcutaneous administration of a potent pentafluorinated enkephalin analog. (D-Ala2)-F5-Phe4-enkephalin-NH2. General activity, short-term memory, startle, and analgesia, however, were not significantly ... | 116,247 | [
0.044502,
0.06287743,
-0.4743758,
-0.2233833,
0.02579331,
-0.6737033,
0.1214771,
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0.1538212,
-0.02458077,
0.02208826,
0.1344689,
0.3067888,
-0.07225838,
-0.2774967,
-0.5330631,
-0.4004563,
0.2443429,
0.1438711,
0.3288516,
-0.0380347,
-0.1975688,
-0.1997078,
... |
Effects of d-amphetamine, maprotiline, L-dopa, and haloperidol on the components of the predatory behavior of the ferret, Putorius furo L. | Ferret predation on rats was examined in an arena. One hour before the test one of the following drugs was administered. d-Amphetamine (0.8 and 1.4 mg/kg IM), MAPROTILINE (10 AND 40 Mg/kg orally), L-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg IM). Provided that capture was successful, the sequence... | 116,280 | [
-0.02249257,
0.3186897,
-0.1505718,
-0.1696408,
0.4157995,
-0.3656938,
-0.02486062,
-0.0543787,
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-0.16767,
0.09794369,
-0.002928296,
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0.1969762,
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0.2795646,
-0.3764693,
0.3824246,
-0.03771455,
0.03765178,
0.006041187,
0.00537017,
-0.019... |
Neonatal death in babies with rhesus isoimmunization. | In the 27 years, 1951--1977, 4315 babies weighing over 1 kg were born alive in Newcastle suffering from haemolytic disease of the newborn due to Rhesus isoimmunization; 197 (4.5 per cent) died within four weeks of delivery. Many babies with severe anaemia (cord Hb less than or equal to 8 g/dl) died of cerebral and/or p... | 116,300 | [
-0.3015472,
0.1682914,
-0.2222787,
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0.2352487,
-0.1353792,
-0.01669834,
-0.3209516,
0.08571833,
0.1373951,
0.002717489,
0.07845466,
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0.2671869,
0.04672088,
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-0.08157444,
-0.08956879,
-0.1597672,
0.03903693,
0.2759839,
-0.119090... |
Pre-clinical studies of the negative pi-meson beam at TRIUMF. | The pi- flux from the biomedical channel at TRIUMF increases with increasing channel momentum, while the contaminating electron flux decreases. Since the electrons appear to result from conversion of the high energy gamma-rays produced by pi0 decay in the production target, the electron contamination can be reduced fur... | 116,303 | [
-0.02706088,
-0.07366712,
-0.3555356,
0.05039139,
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0.1493006,
0.3638761,
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0.1608853,
0.1561075,
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-0.3515403,
-0.2402762,
0.0592023,
0.5286577,
0.4148648,
0.4717809,
0.158722,
0.... |
The value of B-scan ultrasound following intrauterine fetal transfusion. | B-scan ultrasound performed in 6 patients for a total of 15 intrauterine fetal transfusions provided quick, easy, and reliable confirmation of the fetal intra-abdominal placement of transfused blood. | 116,315 | [
0.03161203,
0.1439116,
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0.298945,
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0.04337377,
0.1682247,
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0.06426667,
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-0.4132013,
0.1201373,
-0.2193051,
-0.3378073,
0.4228406,
0.2132809,
0.01180306,
0... |
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