title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Immunodiffusion tests in gel media with the addition of polyethyleneglycol 6000 for the serodiagnosis of mycoses]. | Different immunodiffusion techniques with and without the addition of polyetilenglycol 6000 (PEG), were studied to determine its effect on the sensitivity of these reactions. One hundred thirteen sera from patients who suffered or had suffered deep mycoses (paracoccidioidomycosis: 49, histoplasmosis: 25, aspergillosis:... | 116,327 | [
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[Immunochemical characterization of rabies virus: determination of precipitable antigens]. | Immunodiffusion and immuno-electrophoresis techniques were used to detect rabies precipitable antigens. The passive haemagglutination test with group "O" human red cells treated with tannic acid, was used as control test. The study was done with brain suspensions of rabies virus infected mice (CVS strain). Mouse and ho... | 116,328 | [
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Augmentation of hemagglutination by low ionic conditions. | Short incubation at 37 C, 80 per cent reduction in ionic concentration and removal of liquid phases after each reaction step, provided the basis for the construction of four new serologic tests for alloantibodies to human erythrocytes. In the first, the incubation fluid was replaced with protamine sulfate to aggregate ... | 116,397 | [
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The gangliosidoses: comparative features and research applications. | Ganglioside storage diseases are inherited defects of lysosomal hydrolases that result in intralysosomal accumulation of gangliosides and other complex metabolites. Gangliosidoses occur in man, cats, cattle, dogs and swine. In all species, these diseases are characterized clinically by relentlessly progressive neurolog... | 116,415 | [
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Ventilation-perfusion studies in suspected pulmonary embolism. | The results of ventilation-perfusion (V-Q) imaging and pulmonary angiography were retrospectively analyzed in 146 patients with suspected pulmonary embolism (PE) to define the frequency of PE associated with various scintigraphic patterns. When the radionuclide images demonstrated at least two moderate-sized or one lar... | 116,491 | [
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Evaluation of contrast markers for CT aspiration biopsy. | Precision percutaneous needle aspiration biopsy under guidance of computed tomography is facilitated by injection of a small amount of contrast material during the biopsy procedure. CT scan immediately after biopsy clearly documents the biopsy site. There was no adverse effect of the contrast agents on the quality of s... | 116,500 | [
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Three methods for determining anteversion and retroversion of a total hip prosthesis. | Three new methods to assess the degree of anteversion or retroversion of the femoral component of a total hip prosthesis are described. Compared with previously described methods, the new methods make few physical demands on the recently operated patient. The only requirement is that the affected femur be held in a neu... | 116,505 | [
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Folacin deficiency and requirement in the squirrel monkey (Saimiri sciuresus). | Acute folacin deficiency was studied in eight young squirrel monkeys (Saimiri sciureus). Half of the animals were fed a semipurified deficient diet (no added folic acid) and half were fed a control diet (0.84 mg of added folic acid per kilogram of dry diet). Monkeys fed the deficient diet lost weight and suffered from ... | 116,540 | [
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Infection rates of Ascocystis-infected Aedes triseriatus following ingestion of La Crosse virus by the larvae. | The La Crosse (LAC) virus infection rate of Aedes triseriatus larvae that ingest LAC virus does not appear to be increased by concomitant infection of larvae by the gregarine parasite, Ascocystis barretti. Infection rates ranged only from 0--2.6% in adult Ae. triseriatus reared from groups of A. barretti-infected larva... | 116,554 | [
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Plasmodium fragile and Macaca mulatta monkeys as a model system for the study of malaria vaccines. | Pladmodium fragile and the Macaca mulatta monkey are presented as a model system for the study of malarial vaccines. Four animals were immunized with culture-grown P. fragile merozoites and subsequently challenged with culture-produced parasites. One animal failed to develop a detectable parasitemia following primary c... | 116,557 | [
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Immunogenetic studies of rhesus monkeys. 6. Absence of the human Xga blood group on rhesus erythrocytes. | It was not possible to demonstrate Xga on the erythrocytes of any of 140 rhesus monkeys of both sexes tested with human antiserum rendered specific for Xga by absorption. | 116,572 | [
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The absence of protein--sparing effects utilizing crystalline amino acids in stressed patients. | The protein-sparing effects of the peripheral infusion of crystalline amino acids (PAA) was studied metabolically in selected surgical patients subjected to various degrees of stress. Twenty-one patients (sixteen cancer patients receiving chemotherapy and/or radiotherapy, three with major abdominal traumatic injuries a... | 116,604 | [
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[Outcome of myocardial infarctions complicated by heart conduction disorders in the acute phase]. | Of 945 patients hospitalised for myocardial infarction between January 1st 1972 and December 31st 1975, 40 with anterior myocardial infarction (Group I-A) and 53 with posterior myocardial infarction (Group II-A) were complicated by atrioventricular and/or intraventricular arrhythmias. The average follow up period is no... | 116,618 | [
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[Painless ST elevation with syncope. Diagnosis by continuous electrocardiography]. | The aetiology of syncope in a 53 year old man was discovered on continuous ambulatory electrocardiography. A ventricular arrhythmia associated with ST elevation was recorded. It proved resistant to medical therapy and a double aorto-coronary bypass graft was performed. Post-operative Holter monitoring showed surgery to... | 116,620 | [
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Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. | Induction of hepatic microsomal mono-oxygenase species after administration of various xenobiotics is a well-documented phenomenon. To examine the number and specific species of rat liver microsomal membrane polypeptides involved in such responses, we have used sodium dodecyl sulphate/polyacrylamide-gel electrophoresis... | 116,655 | [
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Inhibition of mammary carcinogenesis of dimethylbenzanthracene treated rats with a brominated triphenylethylene. | Daily administration of a brominated triphenylethylene (TBP), to rats which received 20 mg of DMBA p. o. inhibits mammary carcinogenesis. The effect appears even with very small doses (i ppm in the diet) and seems to be dose related. With one exception (an adenofibroma) the tumours in control and treated animals were m... | 116,693 | [
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Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. | Platelet lipoxygenase and cyclo-oxygenase pathways were investigated by the incubation of 1(-14) C-arachidonic acid with washed platelets in 33 patients with myeloproliferative disorders, including 14 patients with chronic myeloid leukemia (CML), 12 with polycythemia vera (PV), 4 with essential thrombocythemia (ET), an... | 116,695 | [
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Vasoactive material present in the glomerula caudalia of the Vervet monkey. | Complex encapsulated neurovascular structures, glomus organs, occur in superficial and deep positions in many species. No direct evidence for their function exists. In skin they may serve thermoregulation by the reason for their structural complexity remains obscure. The concept of a local humoral circulatory control m... | 116,696 | [
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Plasticity in speech organization following commissurotomy. | For three-and-a-half years we have been studying the cognitive and conscious mechanisms in a remarkable 18-year-old man: Case P.S. This unique individual had his corpus callosum divided in order to control intractable epilepsy. Although for some time after the operation he appeared like other split-brain patients, unab... | 116,711 | [
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Vaterite, a constituent of the eggshells of the nonparasitic cuckoos, Guira guira and Crotophagi ani. | The crystalline spherules occurring in patches on the outer surface of the eggshells of Guira guira and the bloom on the entire outer surface of those of Crotophagi ani were shown by X-ray diffraction analysis to be vaterite. | 116,746 | [
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Infrared absorption bands from NCO- and NCN2- in heated carbonate-containing apatites prepared in the presence of NH4+ ions. | Infrared bands at about 2200 and 2010 cm-1 in the spectra of heated synthetic and biological CO3Aps are assigned to cyanate and cyanamide ions respectively. The formation of these ions is associated with the presence of nitrogenous species in the unheated materials. | 116,758 | [
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Fine structure of isolated fibrils from the cuticle of Lumbricus sp. | A method has been developed to isolate and purify cuticular fibrils of Lumbricus. Polarizing microscopy confirms the collagenous nature of the isolated fibrils. Study in the electron microscope of isolated fibrils, negatively or positively stained, shows that they are cylindrical, unbranching and without periodic struc... | 116,769 | [
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MICC cytotoxic effector function of human T lymphocyte subpopulations bearing Fc-receptors for IgG and IgM. | Purified subpopulations of human T lymphocytes bearing Fc-IgG and Fc-IgM receptors were studied for their ability to mediate mitogen (PHA) induced cellular cytotoxicity (MICC) to chicken erythrocyte (CRBC) and DBA/Mastocytoma P815Y tumour cell targets. There were marked differences in the ability of the Fc-IgG receptor... | 116,786 | [
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Structure and properties of the putrescine carbamoyltransferase of Streptococcus faecalis. | Ornithine and putrescine carbamoyltransferases from Streptococcus faecalis ATCC11700 have been purified and their structural properties compared. The molecular weight of native ornithine carbamoyltransferase, measured by molecular sieving, is 250 000. It is composed of six apparently identical subunits with a molecular... | 116,850 | [
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Craniofacial growth in olive baboons (Papio cynocephalus anubis): browridge formation. | The examination of a developmental series of skulls of olive baboons has led to the generation of a model for browridge formation. Evidence in support of the model comes from surface configuration of browridge bone as studied by scanning electron microscopy, histology of the bone by the analysis of thin sections and by... | 116,911 | [
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Control of glycogen metabolism in the developing turkey poult. | An experiment was conducted with young turkey poults to evaluate factors controlling glycogen metabolism in the period following hatching. Glucose and sucrose solutions were given along with a standard starter diet. Liver and carcass glycogen were measured on days 1, 4 and 6. Liver glycogen synthetase (EC 2.4.1.21) and... | 116,912 | [
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Female aggression and male membership in troops of Japanese macaques and olive baboons. | A detailed comparison of Macaca fuscata and Papio anubis reveals that female aggression to males has an effect on male association with females in both species, but only in M. fuscata do females appear to be able to limit the number of males in their troop. It is suggested that this is the reasons why 'solitary' males ... | 116,946 | [
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Enzyme immunoassay for detecting Brucella antibodies in cow's milk. | An enzyme immunoassay (EIA) was developed for detecting Brucella antibodies in milk of cows infected with Brucella abortus. The enzyme immunoassay using heat-killed cells of B. abortus strain 19 was of comparable sensitivity to the Brucella ring test in detecting antibodies in milk of a reference positive control cow e... | 117,023 | [
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0.2068722,
0.009061232,
0.1603771,
-0.2459122,
-0.1094044,
-0.882678,
0.3910521,
-0.3818073,
-0.02459507,
0.4562107,
0.2818689,
-0.0597859,
... |
Use of 2-mercaptoethanol to facilitate detection and classification of IgM abnormalities by immunoelectrophoresis. | IgM immunoglobulins in elevated serum concentrations have a tendency to polymerize and form aggregates. When subjected to immunoelectrophoreses these proteins may deposit at the point of origin. This can result in failure to detect an IgM abnormality or the masking of other serum protein abnormalities migrating near th... | 117,053 | [
-0.09716001,
0.1212526,
0.06905612,
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0.08225621,
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0.01609476,
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0.235789,
0.1633029,
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-0.03683435,
0.0... |
The effects of UVB and 7, 12, dimethylbenz(alpha)anthracene (DMBA) on epidermal melanocytes of the tail in C57BL mice. | The morphological and numerical changes in the epidermal melanocyte system of the tail of C57BL mice were studied after exposure to 7, 12 dimethylbenz(alpha)anthracene (DMBA) followed by UVB irradiation. The dorsal aspect of the tail was exposed for 5 days per week, for a total duration of 10 weeks, to a daily dosage o... | 117,059 | [
0.08704218,
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0.07400436,
0.3606817,
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0.1269005,
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0.1384121,
0.3097602,
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0.09220112,
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0.037683,
0.4534452,
0.1698472,
0.03278701,
-0.1593... |
Ovarian activity, and total gonadotrophin and gonadotrophin releasing hormone levels in response to some synthetic non-steroidal ovulating agents in the catfish, Heteropneustes fossilis (Bloch). | Effects of clomiphene citrate, cyclofenil and prostaglandins (PGE1 and PGF2 alpha) on ovarian 32P uptake, on gonadotrophin levels in the pituitary gland and blood serum and on a gonadotrophin releasing hormone-like (GnRH-like) substance in the hypothalamus were investigated in Heteropneustes fossilis. These drugs were ... | 117,067 | [
-0.1500198,
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0.07467907,
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-0.07689986,
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-0.2481527,
0.0612517,
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0.02747933,
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0.3062139,
-0.07636131,
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0.1901417,
0.4436549,
0.08752926,
0.3024239,
-0.363... |
Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens. | Specific anti-Lyt antisera and complement were used to determine the Lyt phenotype of peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice. It was found that Lyt 123+ T cells are crucially involved both in protection against listerial infection and in delayed-type hypersensitivity (DTH) to listerial... | 117,073 | [
0.03070595,
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0.01470396,
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0.02051735,
0.03528537,
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0.1240204,
0.03102696,
0.3351517,
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0.1680542,
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0.1202365,
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0.2773086,
0.3374227,
0.2076335,
-0.07580356,
-... |
The intracellular survival and growth of gonococci in human phagocytes. | In reassessment of previous tests for intracellular survival, results have been confirmed and additional evidence obtained indicating that some gonococci can survive and multiply in human phagocytes. Use was made of the ability of penicillin to penetrate phagocytes and to kill only actively growing organisms. In micros... | 117,078 | [
0.03972051,
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0.02779988,
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0.1631893,
0.3632001,
0.4352669,
0.2452308... |
Complete lysis of glutamic acid-producing bacteria by the use of antibiotics which inhibit the biosynthesis of cell walls. | A novel method for obtaining complete lysis of coryneform bacteria has been devised. Bacteria in the late-exponential phase of growth are treated with antibiotics which inhibit biosynthesis of the cell wall. Organisms treated in this way show increased sensitivity to lysis by added lytic enzymes. The preparation of DNA... | 117,079 | [
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0.0561658,
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0.218491,
0.6578768,
0.1982376,
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... |
Bullet injury to the pituitary gland: a rare cause of panhypopituitarism. | An unusual case of head injury with a direct bullet injury to the pituitary gland is described. The hormonal profile one month after the injury showed severe panhypopituitatism which did not improve one month after surgical removal of the intrasellar bullet fragment. | 117,082 | [
-0.2704899,
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0.233989,
0.006083585,
0.003329564,
-0... |
Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices. | 1. The effects of ouabain on renin secretion by rat renal cortical slices were studied. 2. Renin secretion was inhibited by 10(-3) M-ouabain in the presence of free Ca (10(-4) to 2.6 x 10(-3) M). Inhibition was blocked at Ca less than 10(-8) M. 3. The effect of free Ca on ouabain-inhibition was shown to be independent ... | 117,099 | [
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0.3383427,
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0.05959639,
0.... |
3-[(1,2,3-Thiadiazol-5-ylthio)methyl]cephalosporins. | The syntheses of ten 3-](1,2,3-thiadiazol-5-ylthio)methyl]cephalosporins, made by displacement of the 3'-acetoxy group by the novel thiol derivatives, potassium 1,2,3-thiadiazole-5-thiolate and dipotassium 1,2,3-thiadiazole-4-carboxylate-5-thiolate, are described. Several of the compounds showed good in vitro antibacte... | 117,106 | [
-0.1832123,
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0.2811489,
0.00006134688,
0.1106236,
0.132400... |
A new estimate of sequence divergence of mitochondrial DNA using restriction endonuclease mappings. | A new estimate of the sequence divergence of mitochondrial DNA in related species using restriction enzyme maps is constructed. The estimate is derived assuming a simple Posisson-like model for the evolutionary process and is chosen to maximize an expression which is a reasonable approximation to the true likelihood of... | 117,114 | [
-0.0836357,
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0.05518321,
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0.01451887,
0.2935984,
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Peripelvic new bone formation following straddle injuries in hemophiliac patients: report of two cases. | Of 123 patients suffering from either Haemophilia A or B examined at our clinic two were found with peripelvic new bone formation following straddle injuries. An awareness of the possibility of peripelvic ossification should prompt immediate treatment to stop hemorrhage into soft tissues in such cases. | 117,117 | [
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0.2646145,
0.2339692,
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Studies of the toxicity of an intravenous fat emulsion. i. Hematologic changes and survival after administration of a soybean oil (FE-S15) in beagles. | The potential toxicity of FE-S15 (B. Braun-Melsungen), a soybean-oil fat emulsion used in parenteral nutrition, was studied in dogs. Forty pure-bred beagles, in two experimental groups (FE-S15 at 9 and 4 g/kg/day) and two corresponding control groups (receiving Dextrose-Ringer's solution), were given daily infusions fo... | 117,123 | [
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0.4214364,
0.2514733,
0.0370867,
0.6723393,
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0.3304181,
-0.04914583,
... |
Spontaneous zinc deficiency in marmosets, saguinus mystax. | Moustached marmosets, Saguinus mystax, developed alopecia, skin lesions and general debilitation approximately 6 months after being brought into our laboratory. These lesions resembled the signs of zinc deficiency in pigs, rats and squirrel monkeys. The marmosets were fed a commercial monkey diet containing 150 parts p... | 117,220 | [
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0.0764381,
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0.1217686,
0.07283058,
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... |
[Urinary tract infections. Therapeutic failures and course monitoring (author's transl)]. | The proportion of reinfections and relapses in urinary tract infections amounts to about 35-70%. Hydrokinetic conditions (e.g. size of bladder, frequency of micturition, rate of multiplication of the pathogens, adhesiveness of bacteria) not seldom lead to a discrepancy between the in vivo response of the pathogen to th... | 117,322 | [
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0.1429439,
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0.2440757,
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0.09406434,
0.4923206,
-0.06139183,
-0.03886839,
-0.0... |
[Diagnostic significance of cholinesterase determination in human serum (author's transl)]. | The differential diagnostic importance of CHE determination in searching for and observing the course of liver diseases is emphasized in the literature within the small and large enzyme pattern (eg. Gergs 1976). In chronic hepatitis and cirrhosis normal or almost normal values suggest a favorable prognosis. Greatly red... | 117,340 | [
-0.0166539,
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0.1159739,
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0.2558714,
0.02380722,
0.4836695,
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0.07421574,
0.0010973... |
Mutagenic, cancerogenic and teratogenic effects of alcohol. | Alcohol is mutagenic, cancerogenic and teratogenic in man. Ethanol is mutagenic via its first metabolite, acetaldehyde. This is substantiated by the findings that acetaldehyde induces chromosomal aberrations, sister-chromatid exchanges and cross-links between DNA strands. Methanol, a contaminant of many alcoholic bever... | 117,354 | [
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0.07876493,
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0.175758,
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0.1461286,
0.3280938,
0.1323586,
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-0... |
[Treatment of acute renal insufficiency in intensive care. Current perspectives with TPA and proxazole]. | A critical assessment is made of cases of ARF observed in a resuscitation department over the last three years. Reference is made to the physiopathological and pharmacological premises underlying the employment of a different therapeutic protocol, based on the maintenance of high diuresis with proxazol and the use of T... | 117,401 | [
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0.318873,
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0.2833115,
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0.3950796,
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0.02586071,
0.... |
A circulating inhibitor of platelet aggregation in Bartter's syndrome. | Aggregation studies were performed on platelets from five patients with Bartter's syndrome. Epinephrine failed to induce aggregation in all five patients. Adenosine 5'-diphosphate (ADP) produced a single reversible phase of aggregation, and there was depressed sensitivity to collagen. Response to ristocetin was normal.... | 117,424 | [
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0.2969846,
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0.100844,
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0.4731598,
0.2115979,
0.08948099,
-0.04259396,
0.... |
Organochlorine residues in six species of estuarine birds, South Carolina, 1971-75. | In South Carolina between 1971 and 1975, authors evaluated the occurrence of organochlorine residues in the laughing gull (Larus atricilla), white ibis (Eudocimus albus), glossy ibis (Plegadis falcinellus), American oystercatcher (Haematopus palliatus), willet (Catoptrophorus semipalmatus), and ruddy turnstone (Arenari... | 117,426 | [
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0.06623553,
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0.1827286,
0.5908307,
0.269262,
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0.3811702,
-0.2104578,
... |
Residues of polychlorinated biphenyls and DDT in water and sediment of the St. Lucie Estuary, Florida, 1977. | sigma DDT residues in the St. Lucie River bottom sediments increased after Lake Okeechobee water was discharged through the St. Lucie Canal into the area. sigma DDT levels were highest in sediment samples from the Palm City area, ranging from 1.8 ppb to 6.15 ppb. Sediment samples from the A1A Highway Bridge area contai... | 117,428 | [
0.07111037,
0.0213707,
0.1597866,
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0.2326498,
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0.06366378,
0.4015631,
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0.1401709,
-0.07638273,
... |
Further characterization of a cell-free system for measuring replicative and repair DNA synthesis with cultured human fibroblasts and evidence for the involvement of DNA polymerase alpha in DNA repair. | DNA repair synthesis can be specifically measured in osmotically opened, confluent cultured human fibroblasts after exposure to DNA damaging agents such that both induction and mediation of DNA repair synthesis can take place in this cell-free system. Alternatively, by utilizing osmotically shocked, log phase cells and... | 117,431 | [
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0.4740201,
0.542423,
-0.2121101,
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0.154... |
[Products of bacterial destruction of sodium dodecyl sulphate]. | The products of Na dodecyl sulphate destruction by the three bacterial cultures--Pseudomonas aeruginosa, Flavobacterium devorans, Achromobacter guttatus--were examined. The cultures were shown to decompose Na dodecyl sulphate in a similar way. The primary mechanism of destruction was found to be hydrolysis of the sulph... | 117,448 | [
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0.03084761,
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0.2286357,
0.08461552,
0.2184129,
-0.2933795,
-... |
The Ranvier node as a chemo-electric pulsatory unit: a study of its structure-functions relations. | The Ranvier node of (Rana temporaria) frog nerve fibres is investigated by electron microscopy, Particular attention is given to the paranodal septate structures and to the extranodal junction of two Schwann cells. An interpretation of the functional meaning of these structures along with a quantitative analysis of the... | 117,470 | [
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0.1826395,
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0.3209425,
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0.2093371,
0.1508811,
0.1547968,
... |
Effects of trifluoperazine, chlorpromazine, and haloperidol upon temporal information processing by schizophrenic patients. | Healthy controls, unmedicated, actively symptomatic schizophrenics, and similar patients undergoing treatment with either trifluoperazine, chlorpromazine, or haloperidol were studied with tests of temporal discrimination and measures of transmitted information shown previously to be sensitive to various kinds of brain ... | 117,479 | [
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0.1543555,
-0.1078052,
0.3613261,
0.1291197,
... |
Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. | 5-Hydroxytryptamine (5-HT) uptake was studied by using blood platelets from 13 patients with endogenous depression (Hamilton rating scale 33 +/- 7) and 13 healthy volunteers. An improved method with a short incubation time and low substrate concentration was used, and the incubation was performed in Krebs-Henseleit buf... | 117,482 | [
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0.1749392,
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0.4448029,
0.1255014,
-0.02826949,
0.093493... |
Water intake and time course of drinking after single or repeated chlordiazepoxide injections. | Chlordiazepoxide (5.0, 10.0 or 15.0 mg/kg) was given to rats either acutely or for 9 consecutive days. Its effects were examined in a 15-min drinking test in which latency to drink, volume of water consumption and the time-course of drinking were measured. Chlordiazepoxide (10.0 mg/kg) produced the strongest stimulant ... | 117,488 | [
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0.3454188,
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0.3012261,
0.0547221,
-0.003975213,
0.09529268,... |
Involvement of central cholinoceptors in Metrazol-induced convulsions. | Atropine sulphate (10 mg/kg IP) afforded 90% protection against clonic convulsions induced by standard doses of metrazol (80 mg/kg SC) in mice, whereas atropine methonitrate (10 mg/kg IP) did not offer any protection. Furthermore, physostigmine (1 mg/kg IP) caused recurrence of convulsions in atropinzed metrazol-treate... | 117,491 | [
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0.3663347,
0.0231237,
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0.01227427,
0.131... |
[Experimental trachoma]. | During half a century, the agent of trachoma could be mainly demonstrated by inoculation to the conjunctiva of animals; by this mean the cycle of the agent could be revealed. There was a huge progress when T'ANG for these studies inoculated embryonated chicken eggs. However, experimentally infected animals are used at ... | 117,538 | [
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[Is the use of large amounts of glucose in parenteral feeding a problem?]. | Intravenous feeding with glucose as the sole carbohydrate was analyzed in a retrospective study of 30 patients. Very good assimilation of intravenous glucose without dangerous blood sugar variations could be demonstrated. As the administration of glucose was increased stepwise in the initial phase, the incidence of glu... | 117,546 | [
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Highlights of physiological research at the University of Cape Town, 1912-1978. | During the 68 years since it was founded, 548 publications have appeared from the Department of Physiology of the University of Cape Town, which has at different times included subdepartments of pharmacology and of medical biochemistry. The main fields of physiological research have been electrophysiology of the heart ... | 117,559 | [
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[Use of the ECG in bovine cysticerosis]. | In two calves with massive cysticercosis and one healthy control calf the method of electrocardiographic examination was applied to a preciser determination of the clinical finding. The examination was performed on the 75th day after the experimental infection. Singly recorded electrocardiographic findings provided no ... | 117,596 | [
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[Ultrastructure of the double and multiple flagella of the sperm of the drake]. | The structure of double and multiple flagella of the spermatozoa of a drake was investigated. In spermatozoa with this defect one or two implantation pits were observed in the head of the spermatozoon with one or two proximal centrioles situated in the extended base of the nucleus. The structure of the proximal centrio... | 117,599 | [
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[Glycoproteins in the blood of dogs after administration of beta, beta'-dichlorodiethylsulphide]. | The protein spectrum of the dog blood serum was studied after the administration of beta,beta'-dichlorodiethylsulphide. Paper electrophoresis was used for this purpose. Fuchsin-positive substances were determined after previous oxidation with periodic acid, which made it possible to reveal that the glycoproteins detect... | 117,600 | [
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[Isotachophoretic isolation of IgD and IgE and production of monospecific antisera against them]. | The method of preparative isotachophoresis in acrylamide gel ensuring a high yield of IgD and IgE with insignificant admixtures of IgG, etc. was used for the isolation of IgD and IgE from the blood sera of myeloma patients. As a result of immunization with these antigens, monospecific IgD and IgE antisera were obtained... | 117,652 | [
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0.4167578,
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-0.042... |
[Immunostimulating activity of the lipopolysaccharides of blue-green algae]. | The whole cells of blue-gree algae and lipopolysaccharides isolated from these cells were shown to stimulate the production of macro-(mainly) and microglobulin antibodies in rabbits. The macro- and microphage indices in rabbits increased significantly after the injection of LPS isolated from blue-green algae 24--48 hou... | 117,655 | [
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-... |
A TSH secreting pituitary tumour causing hyperthyroidism: presentation of a case and review of the literature. | A 45 year old male with a 12 year history of mild hyperthyroidism and a pituitary tumour is presented. He had both clinical and laboratory evidence of hyperthyroidism and his serum TSH was persistently and markedly elevated. A TRH test resulted in no further rise in serum TSH. No evidence of pituitary or peripheral end... | 117,663 | [
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... |
Pseudothrombocytopenia due to agglutinins. | Pseudothrombocytopenia may have any of a number of causes, one of which is agglutination in vitro. This phenomenon was found in samples of blood from six patients. A serum factor responsible for the agglutination was demonstrated. The factor was dependent upon the presence of EDTA and was more active at room temperatur... | 117,695 | [
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Dyggve-Melchior-Clausen syndrome: genetic studies and report of affected sibs. | We report a brother and sister with Dyggye-Melchior-Clausen dysplasia with mental retardation (MR) but as yet without spinal cord injury due to cervical spine abnormality. Mucopolysaccharide metabolism was studied in several ways and was found to be normal. Segregation analysis and study of consanguinity data confirm t... | 117,710 | [
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Cricopharyngeus myotomy as the only treatment for Zenker diverticulum. | Cricopharyngeal dysfunction, one of the most common causes of pharyngeal dysphagia, exhibits a variety of manifestations, one of which is Zenker diverticulum. This paper examines the physiology of swallowing, pathophysiology of its aberrations, and various methods of treating Zenker diverticulum. It is our purpose to e... | 117,733 | [
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Chemical characterization of a new Japanese variant of carbonic anhydrase I, CA INagasaki 1 (76 arg leads to gln). | A new inherited variant of carbonic anhydrase I (CA I), designated CA INagasaki 1 (CA INGS 1), was discovered during a survey of hemolysates from 5852 individuals from the cities of Hiroshima and Nagasaki in Japan. Analysis of the amino acid composition of a tryptic peptide from the CA INGS 1 variant indicated that a g... | 117,793 | [
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Purification and enzymatic properties of lysyl hydroxylase from fetal porcine skin. | Lysyl hydroxylase from fetal porcine skin is shown to bind in a highly specific manner to aminoethyl-Sepharose 4B. When coupled to ammonium sulfate fractionation and DEAE-cellulose chromatography, chromatography of lysyl hydroxylase preparations on aminoethyl-Sepharose 4B has yielded a highly purified (greater than 95%... | 117,833 | [
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0.048... |
Evidence for the resistance of thyrotropin-releasing hormone (TRH) and pseudo-hormone, pyroglutamyl histidyl-amphetamine, to degradation by enzymes of the digestive tract in vitro. | TRH and pseudo-hormone (pyro Glu-His-amphetamine) were submitted to the digestion of chymotrypsin and prolidase and independently to the digestion of enzymes of the digestive track: pepsin (stomach), pancreatins (pancreas) and enzymes extracted from the intestinal mucosa (small intestine). Using thin layer chromatograp... | 117,843 | [
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Immunohistochemical localization of thyrotropin-releasing hormone (TRH) in skin of Rana pipiens. | Using immunofluorescent techniques thyrotropin releasing hormone (TRH) is demonstrated in skin of Rana pipiens and R. catesbeiana. The immunofluorescent-TRH is localized in all cell layers of the epidermis and in the epithelium lining the various cutaneous glands, but not in the dermal layer. | 117,895 | [
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In vitro induced pinocytotic activity by a juvenile hormone analogue in oocytes of Drosophila melanogaster. | Pinocytotic activity has been analyzed in Drosophila oocytes following either in vivo or in vitro exposure to horseradish peroxidase. The enzyme tracer gains access to the yolk spheres only when supplied to the oocyte in vivo. In oocytes cultured in vitro, peroxidase remains restricted to the residual coated vesicles a... | 117,896 | [
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[Unmasking of the fast sodium channel in less than 4 day old embryonic chicken heart by inhibitors of sodium inactivation]. | Embryonic Chick hearts aged less than 4 days are not always sensitive to tetrodotoxin, an inhibitor of fast sodium channel. It is shown that in the most frequent cases, in which tetrodotoxin sensitivity is apparently absent, this sensitivity can be demonstrated after previous treatment by veratridine or by toxin II of ... | 117,932 | [
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... |
[Effect of cell proliferation on the condensation of the X chromosome in culture medium of the individual karyotype 49 XXXXX]. | The influence of cell proliferation on the condensation of the X chromosome was observed in vitro in human fibroblasts with 49 XXXXX karyotype. The frequency of cells with four Barr-bodies is low during the logarithmic growth phase and increases to 80% when the cells are becoming confluent or, independently of cell con... | 117,944 | [
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[Isolation of the yellow fever virus from an egg-cluster and the larvae of the tick Amblyomma variegatum]. | The yellow fever virus is isolated in natura from eggs of a Tick Amblyomma variegatum. It is then isolated from larvae issued from the same egg-cluster and also from blood of a monkey bitten by larvae of the same origin. It is reported that the same virus has been previously obtained from adults of the same species of ... | 117,946 | [
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... |
The effect of lisuride hydrogen maleate, an ergot derivative on anterior pituitary hormone secretion in man. | The effects of single oral doses of 0.2 mg of lisuride hydrogen maleate, a semisynthetic ergot derivative, on serum levels of prolactin (PRL), growth hormone (GH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), cortisol and blood glucose were studied in six normal males... | 117,952 | [
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-... |
A simplified technique to prepare fungal specimens for scanning electron microscopy. | A simplified technique to prepare fungal specimens for scanning electron microscopy is described and discussed. Fixation in either 6% glutaraldehyde or 2% Os04 (both unbuffered aqueous solutions), yielded good results. The minimum fixation time in OSO4 was 2 h, in glutaraldehyde 4 to 5 h. Chemical dehydration with 2-me... | 117,981 | [
-0.3378152,
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-0... |
Episodic and TRH induced growth hormone release in primary hypothyroidism of man and rat. | In 27 hypothyroid subjects studied over 20 to 120 minutes, the concentration of serum growth hormone (GH) was variable with the amplitude and frequency of the secretory patterns similar to those reported by others for normal individuals. Serum GH, after the administration of thyrotropin releasing hormone (TRH) did not ... | 118,000 | [
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Vestibular nuclei activity in the alert monkey during suppression of vestibular and optokinetic nystagmus. | Single neurons were recorded in the vestibular nuclei of monkeys trained to suppress nystagmus by visual fixation during vestibular or optokinetic stimulation. During optokinetic nystagmus vestibular nuclei neurons exhibit frequency changes. With the suppression of optokinetic nystagmus this neuronal activity on averag... | 118,047 | [
-0.2456409,
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0.01063548,... |
Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique. | The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recomm... | 118,073 | [
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-... |
Evaluation of the teratogenicity of anticonvulsants. | Evaluation and comparison of the reports on teratogenicity of drugs are very difficult because many fundamental, clinical and social problems exist in the research of congenital anomalies and detection of human teratogens. Since the etiological significance of anti-convulsants has not been established in humans, the fo... | 118,096 | [
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... |
Immune mechanisms against canine distemper. II. Role of antibody in antigen modulation and prevention of intercellular and extracellular spread of canine distemper virus. | Specific antibody was shown to be highly effective in neutralizing extracellular canine distemper virus (CDV) as well as preventing the intercellular spread of this virus. Thus, relatively low levels of antibody neutralized 1 x 10(5) TCID50 of extracellular CDV and the development of plaques or CPE in Hep-2 and Vero ce... | 118,114 | [
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-0.2247475,
-... |
[Balanced parenteral and oral feeding of underweight newborn infants]. | The oral feeding of 50 newborns with low birth weight was combined with infusions of two different amino acid solutions (mother milk-adapted and requirement-adapted), parenteral lipids and glucose. All infants showed a rapid weight gain, the N-balance became positive, hypoglycemic or hyperosmotic reactions were missing... | 118,117 | [
0.1534222,
-0.264069,
-0.1678168,
-0.111683,
0.2789817,
-0.08048278,
-0.05204467,
-0.2390351,
-0.03304914,
0.08975098,
-0.0248558,
0.2268528,
-0.009922672,
-0.140587,
-0.4321196,
-0.5227093,
-0.5550236,
0.2112195,
-0.1810123,
0.0780064,
0.2862481,
0.008612772,
0.1045284,
... |
Deoxyribonucleic acid repair capacities of Neisseria gonorrhoeae: absence of photoreactivation. | No difference in survival was observed when ultraviolet-irradiated gonococcal cells were subsequently incubated in the dark or exposed to photoreactivating light. This observation indicates that photoreactivation is absent in Neisseria gonorrhoeae. | 118,154 | [
-0.07226156,
-0.1386744,
-0.3603476,
-0.2267769,
0.01417551,
-0.06833431,
-0.1872975,
-0.1617043,
0.2855873,
-0.1390983,
0.151362,
0.1903859,
-0.06862754,
0.104995,
-0.3229793,
-0.07981261,
-0.4225802,
0.1456919,
-0.1908544,
0.2283214,
0.4665323,
0.07793587,
0.01971858,
... |
Synthesis of nitrogenase and heterocysts by Anabaena sp. CA in the presence of high levels of ammonia. | Anabaena sp. CA fails to synthesize heterocysts and nitrogenase when grown with KNO3 as the nitrogen source. By contrast, both heterocysts and proheterocysts are synthesized in NH4Cl-containing media to a level nearly commensurate with cells grown in the absence of combined nitrogen. The growth rate of the organism in ... | 118,162 | [
-0.348495,
-0.1362241,
-0.2907759,
-0.1447407,
-0.4885874,
-0.1980411,
-0.1318565,
0.008306643,
0.2774481,
-0.2923842,
-0.2055656,
0.09752665,
0.1177154,
0.01500393,
-0.4589987,
0.1634361,
-0.3701542,
-0.1765153,
0.08568218,
-0.1931104,
0.5172308,
0.2092664,
-0.100179,
... |
Characterization of polyriboadenylate polymerase from Tetrahymena pyriformis. | Poly(A) polymerase [polyadenylate nucleotidyltransferase, EC 2.7.7.19] was extracted from Tetrahymena pyriformis. The enzyme was demonstrated to be present in three forms by column chromatography on DEAE-cellulose, and they were termed poly(A) polymerase Ia, Ib, and II in order of increasing affinity to the column. The... | 118,167 | [
-0.1466632,
-0.1221618,
-0.1097964,
0.06171105,
-0.04210884,
-0.003759679,
-0.2637557,
0.217059,
0.05674177,
-0.1652742,
0.2026953,
-0.312708,
0.1428739,
0.01088778,
0.09893429,
0.1340961,
-0.1780663,
0.02354524,
0.2893024,
0.2852431,
0.4815081,
0.2489759,
-0.1408018,
0... |
Microbiology subsystem of a total, dedicated laboratory computer system. | The computer system used by the Microbiology Service of the Clinical Pathology Department, Clinical Center, National Institutes of Health is discussed. This microbiology subsystem is a part of a dedicated on-line laboratory computer system used by the entire department. The laboratory computer is connected on-line to a... | 118,177 | [
-0.08823615,
0.08726066,
0.1747154,
0.08777085,
-0.2173295,
-0.2468319,
-0.1302189,
0.2416933,
0.07804579,
0.01872875,
-0.09804321,
0.04185533,
0.1077855,
0.401246,
-0.5936416,
0.1993002,
0.02987671,
-0.09706369,
0.1811349,
-0.2440785,
0.2944245,
0.1994198,
-0.2854749,
... |
Antithrombin activities in childhood malnutrition. | Antithrombin activities in 30 severely malnourished children and 40 normal children were estimated in clotting tests by thrombin neutralisation as anti-Xa and by a heparin antithrombin assay; and by immunodiffusion as alpha 2-globulin and alpha 1-antitrypsin. The patients' mean alpha 2-globulin was severely depressed, ... | 118,190 | [
0.03479398,
0.1746362,
-0.3573835,
-0.01638896,
0.1686467,
-0.1325931,
-0.2719606,
0.1409208,
-0.2037057,
0.06659134,
0.1406431,
0.4542486,
-0.1072431,
0.05294119,
-0.1551083,
-0.0548959,
0.1172574,
0.2257942,
0.0929713,
0.1501326,
0.3793081,
-0.007110583,
-0.001106959,
... |
Double labeling immunohistochemical technique provides evidence of the specificity of glial cell markers. | Sequential treatment of rat cerebellar slices with two antisera, each specific for a different glial cell marker, revealed, by indirect immunofluroescence combined with the immunoperoxidase method on the same tissue section, that carbonic anhydrase isoenzyme II (CA II) is exclusively localized in oligodendrocytes while... | 118,210 | [
0.05667092,
-0.2333577,
0.09799296,
-0.1281578,
0.06575353,
-0.2421629,
-0.173618,
-0.08719738,
0.07846565,
0.09575849,
-0.1627624,
0.3035952,
0.2127405,
-0.02514894,
-0.1515066,
-0.1247066,
-0.3214167,
0.07914098,
-0.3778188,
0.2348142,
-0.07589447,
0.1018143,
-0.1679651... |
Characterization of infection and replication of Mason-Pfizer monkey virus in human cell cultures. | Human cells derived from both normal and neoplastic tissues can be infected by Mason-Pfizer monkey virus (MPMV) without accompanying cytopathology. Infection of cell cultures such as human rhabdomyosarcoma (A204) results in a persistenly infected cell line which can be subcultured over 30 sequential culture passages wi... | 118,235 | [
-0.4904629,
-0.05256896,
-0.05912114,
-0.3226991,
0.1783319,
-0.03331636,
-0.193891,
0.2671983,
0.09852803,
0.04774637,
-0.0418075,
0.1117848,
0.00001101506,
0.1619464,
-0.49548,
-0.03549345,
-0.1903906,
-0.2247234,
-0.05342225,
0.1772916,
0.4329563,
-0.09790568,
-0.17340... |
Changes in the virus-host cell relationship in a stable non-virogenic cell line persistently infected with measles virus (BGM/MV). | A non-virogenic African green monkey kidney cell line BGM/MV persistently infected with a neurotropic mouse brain-adapted strain of measles virus, was found to have undergone significant changes in the virus-host cell relationship between passages 35 and 119. Rather than the stable non-cytopathic relationship previousl... | 118,238 | [
-0.5226394,
-0.2723854,
-0.1244733,
0.2408003,
0.306067,
-0.127875,
-0.2217695,
0.2746099,
-0.02976423,
-0.2424593,
-0.2093152,
0.5563492,
0.08677739,
-0.2364447,
-0.2176557,
-0.2233019,
-0.1988199,
-0.1068488,
-0.1114738,
0.117273,
0.3537795,
-0.2151534,
-0.1201204,
-0... |
Co-translational modification of nascent immunoglobulin heavy and light chains. | We have investigated the in vivo co-translational covalent modification of nascent immunoglobulin heavy and light chains. Nascent polypeptides were separated from completed polypeptides by ion-exchange chromatography of solubilized ribosomes on QAE-Sephadex. First, we have demonstrated that MPC 11 nascent heavy chains ... | 118,307 | [
-0.1002031,
0.1421278,
-0.1861624,
-0.03671011,
0.02107825,
-0.1239706,
-0.03675738,
0.1641836,
0.06434625,
0.4919754,
-0.001682262,
-0.0327888,
0.18725,
0.05998625,
-0.1550773,
-0.05946387,
-0.4662553,
-0.281868,
-0.05007489,
-0.03752735,
0.7006777,
-0.003980125,
0.07914... |
[A controlled study on the significance of occult blood test in the stool (author's transl)]. | 1000 patients of a proctological practice were all investigated by coloscopy and parallel to this by comparison of the two tests for occult blood in the stool (Haemoccult and hemo FEC). 5,6% were positive by the Haemoccult test, 5,2% to hemo FEC. There was no significant difference between the two systems. In the entir... | 118,339 | [
0.07472249,
-0.1176083,
-0.104897,
0.00430799,
-0.210622,
-0.5981812,
-0.01753485,
0.1249963,
0.003299871,
-0.1960808,
0.1816106,
0.4591615,
0.1002344,
-0.3150477,
-0.5022036,
-0.2434501,
-0.374933,
0.1457508,
0.1507765,
0.2088529,
0.369767,
0.06020392,
-0.164495,
0.363... |
Mutagen-sensitive mutants in Drosophila melanogaster: effects on premutational damage. | Drosophila melanogaster males from a Basc stock were mutagenized with either X-rays, ethyl methanesulfonate (EMS), or nitrogen mustard (HN2). Groups of identically treated males were crossed to different types of female. Sex-linked recessive lethals were scored as a genetic end point. The females used were homozygous f... | 118,370 | [
0.154796,
0.02512215,
-0.2240373,
-0.222609,
0.05047039,
-0.02410574,
0.02734792,
-0.2180704,
0.1718094,
0.2050142,
-0.02706137,
0.241434,
0.07424692,
0.1765309,
-0.5161746,
-0.4709687,
-0.214352,
-0.0786277,
0.04934083,
0.269861,
0.4517484,
0.4043184,
-0.03351545,
-0.1... |
Mutagenic effectiveness of 14.1 MeV neutrons and 200 kV X-rays at the dumpy complex locus of Drosophila melanogaster. | The effectiveness of 14.1 MeV neutrons relative to 200 kV X-rays for the induction of the various kinds of dumpy mutation in mature sperm of Drosophila melanogaster was investigated. The estimated RBE values are: 0.52 for all complete mutations; 0.64 for the (olv, ov) types; 0.33 for the (ol, lv, o, v, c) types; 0.33 f... | 118,373 | [
-0.04640791,
0.1664069,
0.03936911,
0.02082369,
0.2181086,
-0.2666467,
0.2587252,
-0.3115289,
-0.1203747,
0.3520634,
0.0948109,
0.3830586,
-0.09336407,
0.1422218,
-0.9878294,
-0.3569076,
-0.5219084,
-0.02808115,
0.5985621,
0.07080512,
0.4074017,
0.6920438,
-0.1587121,
0... |
Effects of caffeine on maternal repair systems in Drosophila melanogaster. Concentration-dependent reversals of the effects of caffeine on chromosome loss and autosome-autosome translocations induced by x-rays in the paternal genome. | Drosophila melanogaster females were treated with 1% caffeine, mated with X-rayed males and the frequencies of induced sex-chromosome loss, translocations between the major autosomes and between the Y-chromosome and the major autosomes determined. In a reversal of the results obtained previously with 0.2% caffeine by M... | 118,376 | [
0.2737231,
-0.07872917,
0.1318963,
-0.05746715,
0.2227681,
-0.1535121,
-0.1552435,
-0.3748443,
0.1377424,
0.0234007,
0.1130716,
-0.1596108,
0.04878585,
0.09214923,
-0.6573394,
0.1507755,
-0.3847642,
-0.01789848,
-0.02491514,
-0.06482547,
0.08821703,
-0.09298171,
-0.200938... |
Mutagenicity and metabolism of dimethylnitrosamine and benzo[alpha]pyrene in tissue homogenates from inbred Syrian hamsters treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls. | There are significant differences between mice and hamsters in polycyclic hydrocarbon and nitrosamine metabolism. Homogenates of liver, lung and intestinal mucosa from 6 strains of Syrian golden hamster were compared for their ability to metabolize benzo[alpha]pyrene (BP) and dimethylnitrosamine (DMN) to mutagens. Fema... | 118,380 | [
0.03104329,
-0.2203233,
-0.05279524,
-0.1596486,
0.04358598,
-0.0468353,
-0.3918436,
0.03234771,
0.2681798,
-0.2753123,
0.166852,
0.3646547,
0.1649113,
0.02583323,
-0.7664546,
-0.01981375,
-0.6825784,
0.00111329,
0.5404435,
0.3709066,
0.4952635,
0.194435,
-0.3218299,
-0... |
[Adrenergic activity and glycometabolic compensation in patients with diabetes mellitus]. | In an assessment of the degree of adrenergic activity in the course of diabetes mellitus, plasma levels and urinary excretion of norepinephrine and epinephrine were determined in 20 normal subjects and 47 diabetics: 11 in good control (group I), 23 in poor control (group II), 13 with frank ketoacidosis (group III). The... | 118,410 | [
0.1145715,
0.1801038,
-0.2266881,
-0.1608581,
0.2579363,
-0.6818879,
-0.3019262,
0.02739861,
0.1160271,
-0.02719314,
-0.02489868,
-0.2553227,
0.05557807,
0.2237221,
-0.3835862,
-0.09773473,
-0.3684777,
-0.03156365,
0.1100755,
0.06160913,
0.05625124,
-0.1070391,
-0.0145120... |
[Unusual CT skull findings after preventive CNS treatment of acute leukemia in children]. | CT examinations of the cranium were carried out among 15 children who had previously received cranial radiation and i.th. methotrexate during leukemia management. Surprisingly, 10 of 15 patients had abnormal CT findings. Only 2 of the 10 "CT-positive" children were clinically-neurologically conspicuous. The visible CT ... | 118,413 | [
0.05867133,
0.1994544,
-0.005832288,
-0.323193,
0.188338,
-0.2497027,
-0.5625633,
-0.2763387,
-0.01254579,
0.05882088,
0.1783318,
0.4556672,
-0.1392494,
0.2059233,
-0.3983229,
0.03966963,
-0.2416432,
0.2292359,
-0.03287347,
0.3674954,
0.2313223,
0.2528285,
-0.0908803,
0... |
Sequences of large T1 ribonuclease-resistant oligoribonucleotides from protamine mRNA: the overall architecture of protamine mRNA. | Limited T1 ribonuclease digestion of the family of protamine mRNA's purified from rainbow trout testis yields several large oligoribonucleotide fragments ranging in size from 12--54 nucleotides in length. Several of these fragments purified by two dimensional gel electrophoresis contain several G residues and must repr... | 118,437 | [
0.0515397,
0.138769,
-0.5944006,
-0.1719217,
0.08471964,
-0.1468136,
-0.01499922,
0.1174591,
0.3727562,
0.08275422,
0.03665677,
0.1122624,
0.1945913,
-0.1085557,
-0.1595897,
-0.2126406,
0.01956122,
-0.02423988,
0.2941875,
0.04154208,
0.3104438,
0.03496554,
-0.2066733,
-... |
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