title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Unconjugated thyroxine and triiodothyronine in urine: influence of age, sex, drugs and thyroid function. | The 24 h urinary excretion (dU) of T4 and T3, determined by radioimmunoassays using extraction and separation on Sephadex columns, is higher in men than in women (mean dU-T4 and dU-T3 +/- 2 SD: 2.6 +/- 0.9 vs. 2.2 +/- 1.0 and 2.5 +/- 1.0 vs. 2.0 +/- 0.8 nmol, respectively). The excretion of T3 decreases with age, but e... | 118,510 | [
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Effect of phenoxymethylpenicillin and clindamycin on the oral, throat and faecal microflora of man. | Phenoxymethylpenicillin in capsules was given orally in doses of 800 mg twice daily for 7 days to 10 subjects. Saliva, throat and faecal specimens were taken up to 29 days for cultivation of aerobic and anaerobic bacteria. No changes in the normal flora in saliva, throat or faeces were noticed during the observation pe... | 118,526 | [
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Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phosphodiesterase inhibitor phthalazinol (EG-626). | Experiments in monkeys have demonstrated that the chronic vasospasm and arterial injury reaction produced by subarachnoid blood injection can be prevented by treatment with the phosphodiesterase inhibitor phthalazinol. This protective effect, which is present even when the drug treatment is initiated after the subarach... | 118,551 | [
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[Radioimmunological determination of HBeAg/anti-HBe in HBsAg-positive liver diseases and in "healthy" HBsAg carriers]. | This paper describes a "solid-phase"-radioimmunoassay for the demonstration of HBeAg and anti-HBe. The investigations revealed the following results: 1. HBeAg is positive in all patients with acute type B-hepatitis during the acute phase of illness. During the normal course of the disease HBeAg turns to negative follow... | 118,595 | [
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[Differences in postoperative metabolism in reference to pre- and postoperative initiation of total parenteral nutrition. I]. | We investigated the postoperative metabolism of patients undergoing gastric resection by beginning total parenteral nutrition pre- (group 1) and postoperatively (group 2). A third group remained fasting until 3 h after the surgical intervention. Because of the high serum glucose concentrations and the high glucose loss... | 118,594 | [
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Leiomyomatosis cutis et uteri. | A 32 year old female patient showed multiple plaque-like leiomyomata cutis and an uterus myomatosous of early onset. In the skin large areas of plaque-like confluent erythematous nodules consisting of smooth muscle tissue are formed. The patient suffered from frequent attacks of severe pain elicited by temperature chan... | 118,608 | [
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[Atypical antibody against liver cell cytoplasm in virus induced autoimmune hepatitis (author's transl)]. | A high titer (1:500) antibody against liver cell cytoplasm was found in one case of atypical viral hepatitis. The central areas of the rat liver lobule react more intensive than the periphery. Inconstantly it was found a reaction also with the parietal cells of the stomach, with the 3rd segment of proximal rat kidney t... | 118,629 | [
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An atypical manifestation of multiple myeloma in a 24-year-old male. | A structurally unusual, B-cell-derived malignant tumour is reported in a 24-year-old male. The gross autopsy findings were those of classical myelomatosis, with extensive and centrally located skeletal infiltrates and typical myeloma kidneys. The tumour cells were, however, morphologically very unusual. All elements we... | 118,643 | [
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Cellular pathology of homozygous familial hypercholesterolemia. | Tissues were studied from four subjects with homozygous familial hypercholesterolemia (FH). The specimens consisted of tissues obtained from a 20-week-old fetus at autopsy, samples from a 9-year-old girl during open-heart surgery, and biopsies of cutaneous xanthomas from a 13-year-old girl and a 21-year-old man. The FH... | 118,674 | [
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Protection against Klebsiella pneumoniae respiratory tract infection of mice and squirrel monkeys given kanamycin by aerosol and injection. | The methods of aerosol administration of kanamycin and IM injection of the antibiotic were compared for their protection of mice and squirrel monkeys against Klebsiella pneumoniae respiratory tract infection. Mice exposed to LD90 of K pneumoniae at 0.5, 4, 24, 48 and 72 hours after they were treated with aerosol of kan... | 118,692 | [
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Exostoses of the external auditory canal. | Exostosis of the external ear canal is a disease unique to man. It has been identified in prehistoric man, affecting the aborigines of the North American continent. Aural exostoses are typically firm, sessile, multinodular bony masses which arise from the tympanic ring of the bony portion of the external auditory canal... | 118,696 | [
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Ultrastructural aspects of normolipidemic xanthomatosis. | Electron microscopic aspects in ten cases of normolipidemic cutaneous xanthomatosis have been investigated. Two additional types IV and V hyperlipoproteinaemic xanthomatosis have also been included. Ultrastructural findings in all cases were similar. Abundant histiocytic cells with numerous intracytoplasmic lipid vacuo... | 118,710 | [
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The effects of food deprivation and re-feeding on bovine adipose-tissue glycogen synthase. | Bovine adipose-tissue glycogen metabolism was studied during food deprivation and re-feeding. Changes in the specific activity of adipose-tissue glycogen synthase paralleled changes in tissue glycogen content: both parameters increased during food deprivation and remained so during the first 10 days of re-feeding. The ... | 118,747 | [
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[Involution of genital function with age studied as an index aging in Drosophila melanogaster]. | Reproductive system in Drosophila estimated by fertility in female and fertilizing power in male gradually decreased with age. Physiological changes as a function of age occur slowly in virgin females and their ageing seems really slower than those observed in inseminated ones. On the other hand, genital function invol... | 118,815 | [
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An enzyme immunoassay for the measurement of thyroglobulin in human serum. | An enzyme-linked sandwich immunoassay using silicone rods coated with rabbit (anti-human thyroglobulin) immunoglobulin G and rabbit (anti-human thyroglobulin) monovalent fragment of immunoglobulin F (Fab') conjugated with beta-D-galactosidase was developed for the measurement of thyroglobulin in human serum. The volume... | 118,829 | [
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Binding of serum amyloid P-component (SAP) by amyloid fibrils. | Serum amyloid P-component (protein SAP) was found to bind in vitro to isolated amyloid fibrils of both primary and secondary types. The binding was strictly calcium-dependent, optimal uptake requiring at least 0.5 mM calcium ion. Using normal human serum as the source of protein SAP different fibril preparations became... | 118,839 | [
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The functional roles of cytochrome P-450 mediated systems: present knowledge and future areas of investigations. | Research in recent years has considerably enhanced our understanding of the membrane-bound cytochrome P-450-catalyzed biotransformations in organisms. A remarkable similarity has become apparent between diversified animal groups with respect to the components and functional roles of the cytochrome P-450 systems. For ex... | 118,858 | [
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[The effects of ordinary provocation on the power density spectrum. A clinical electroencephalographic study (author's transl)]. | In the search for methods which might increase the discrimination of the EEG, the power density spectra of a random sample of patients during different conditions were analysed. Power density spectra were made during eyes closed, eyes open, after hyperventilation, during photic stimulation, and during auditory stimulat... | 118,866 | [
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[Electromyographic differential diagnosis in cases of abducens nerve paresis with nuclear or distal neurogenic sive myogenic origine (author's transl)]. | Abducens nerve paresis may be of nuclear, of peripheral distal neurogenic origine, or is simulated by a myogenic weakness of abduction. Polygraphic emg analysis of the oculoauricularphenomenon (oap) permits a differentiation. In the emg, the oap proved to be a physiologic and constant automatic and always bilateral int... | 118,867 | [
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The lecithin/sphingomyelin ratio in Macaca arctoides. | The amniotic fluid lecithin/sphingomyelin ratio (L/S ratio) of stumptail macaque monkeys (Macaca arctoides) was investigated by means of serial amniocenteses during the second half of pregnancy. Ten dated pregnancies were studied in 9 individual monkeys. The mean number of successful amniocenteses per pregnancy was 4. ... | 118,898 | [
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Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. IV. In vitro synergism between neoviridogrisein II and the antibiotics of the mikamycin A group. | Neoviridogrisein II is a homologue of viridogrisein in which the hydroxyproline residue is replaced by proline. Neoviridogrisein II proved to be more active than the parent antibiotic against Gram-positive bacteria and Mycoplasma species. When neoviridogrisein II or viridogrisein was combined with griseoviridin, a non-... | 118,957 | [
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Comparative bactericidal activities of beta-lactam antibiotics determined in agar and broth media. | Comparative bactericidal activities were determined utilizing a relatively large number of test strains, in both agar and broth media, with special reference to the time of exposure of the bacteria to certain beta-lactam antibiotics. It was apparent that the activities increase with time. The concentrations producing a... | 118,959 | [
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Comparison of the 95,000 molecular weight protein from Limulus sperm with muscle alpha-actinin. | The 95,000 molecular weight protein (95K protein) of the false discharges of Limulus sperm, purified by means of preparative gel electrophoresis in the presence of sodium dodecyl sulfate, was compared with a 95K protein from Limulus muscle and chicken gizzard alpha-actinin. The results were as follows. 1) One-dimension... | 118,967 | [
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Serum thyroid hormone concentrations and weight loss relationships in eight obese women during semistarvation. | Eight obese female patients were studied over a period of 15 days whilst on 300 kcal diet. Serum levels of thyroxine and free throxine index were not altered significantly by semistarvation. A TRH test performed before and after the diet showed no appreciable change. Weight loss was intially rapid but later slowed desp... | 118,991 | [
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The role of natural IgG and complement in the phagocytosis of type 4 Neisseria gonorrhoeae by human polymorphonuclear leukocytes. | The role of human serum components in the phagocytosis of logarithmic-phase type 4 Neisseria gonorrhoeae by human polymorphononuclear leukocytes was investigated. The requirement of fresh normal human serum (FHS) for optimal phagocytosis and the fixation of human immunoglobulin (IgG) and complenet (C3) to the gonococca... | 118,998 | [
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Chemotaxis towards sugars by Bacillus subtilis. | Many sugars and derivatives were tested in the capillary assay for their attraction of Bacillus subtilis. The major attractants were 2-deoxy-D-glucose, D-fructose, gentiobiose, D-glucose, maltose, D-mannitol, D-mannose, N-acetylglucosamine, alpha-methyl-D-glucoside, beta-methyl-D-glucoside, N-acetylmannosamine, alpha-m... | 119,030 | [
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Primate disease and breeding rates. | 33 species were compared for 12 disease categories over 3 years of laboratory housing. There were low correlations between popularity, birth, death, and illness rates. Highest rates were: birth, Macaca nemestrina; illness, Pongo pygmaeus; death, Cercopithecus aethiops. Lowest rates were: birth, Lemur catta; illness, Sa... | 119,108 | [
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Urinary cystic calculi in a cynomolgus monkey (Macaca fascicularis): a case report. | An adult female Macaca fascicularis monkey became acutely anorexic and depressed and was found dead approximately 24 hours later. Necropsy revealed three hard brownish-yellow stones within the urinary bladder and urethra, a moderately shrunken left kidney, hemorrhage of the medulla of the left adrenal gland and a yello... | 119,114 | [
-0.08937319,
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0.364217,
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0.2632934,
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-0.2677652,... |
Bowel preparation with mannitol. | Orally administered mannitol has been used for colonic preparation before operations, for colonoscopy, and before barium enema X-ray examinations. It is quick, effective, comfortable, safe, and cheap. The metabolic effects have been evaluated and found to be minimal, and recommendations for the use of orally administer... | 119,149 | [
-0.07952463,
0.07318559,
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0.0009403923,
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0.1333366,
0.006807382,
-0.08994258,
0.2087916,
0.1802021,
0.07893... |
Effect of a single dose of inducers and inhibitors on the rate of synthesis of cytochromes and reductases in liver organelles. | Measurement of the effect of drugs on the in vivo rates of synthesis of rabbit liver organelle bound proteins were measured following individual treatments with the inducers phenobarbital, 3-methylcholanthrene and PCB (a mixture of polychlorinated biphenyls) and the inhibitors, cycloheximide, aflatoxin B1, chlorampheni... | 119,159 | [
0.07921497,
0.06611057,
0.1623586,
0.4863266,
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0.01850452,
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0.3028164,
0.1478989,
0.03818073,
0.... |
Hormonal requirements for neuronal survival in culture. | The inability to grow neurons in culture in the absence of complex and undefined biological fluids (e.g. serum) has proved a major obstacle to a rigorous formulation of the growth, nutritional and hormonal requirements of the developing nervous system. We have been successful in maintaining dissociated chick dorsal roo... | 119,183 | [
0.05163034,
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0.4370027,
0.2913322,
-0.03304705,
-0.0017... |
Biological effects of some N-substituted (meth)acrylamides. | This paper reports an investigation of the biological effects of monomers of N-substituted (meth)-acrylamides used in the preparation of polymers suitable for medical purposes. By combining tests carried out on cell cultures and on living animals, we found thpheral nervous system. Tests performed on cell cultures can b... | 119,218 | [
-0.4210551,
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0.2602812,
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0.4137637,
0.07761841,
0.2234009,
0.03437099,
-... |
Disruption of taste aversion learning by pentylenetetrazol. | Rats were taught an aversion to a sucrose taste cue (CS) by pairing it with lithium chloride-induced toxicosis (UCS). The CS-UCS interval was 30 min. Animals were injected with pentylenetetrazol (PTZ) (50 mg/kg at 0, 15, 25, 28 or 30 min after the CS in an attempt to disrupt taste aversion learning. Only animals given ... | 119,263 | [
0.03100464,
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0.08579198,
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0.06838772,
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0.2171614,
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-0.04144153,
0.02526649,
0.2422282,
0.07579283,
-0.0005... |
Fluid and electrolyte absorption and renin-angiotensin-aldosterone axis in patients with severe short-bowel syndrome. | In eight patients who had received long-term parenteral nutrition because of short-bowel syndrome the need for parenteral supply of fluid, sodium, and potassium was estimated by balance studies. Six patients had jejunostomies. In two, most of the colon was preserved. Jejunostomy patients had a huge stool mass (1710--52... | 119,306 | [
-0.0534688,
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-0.2419583,
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0.02507118,
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0.2917789,
0.08553886,
0.000559946,
0.05739079,
0.1208087,
0.240178,
-0... |
[Development of enterococci and coli bacteria in Bulgarian yogurt]. | The effect of lactic acid fermentation in Bulgarian yoghourt was studied by the development and decline of hygiene level indicating microorganisms--enterococci and coli-bacteriae. It was established that for the first 6 h after production of Bulgarian yoghourt, the quantity of enterococci (Str. faecalis, resp. Str. fae... | 119,346 | [
-0.01243398,
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0.06413735,
0.06220559,
0.09762693,
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0.1341078,
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0.01733048,
0.2092879,
0.1851289,
0.3474345,
0.6009526,
0.4582146,
-0.1422846,
... |
Studies on the different metabolic pathways of antipyrine in rats: influence of phenobarbital and 3-methylcholanthrene treatment. | 1. The amounts of antipyrine and its metabolites excreted in 24 h urine after i.v. injection of 10 mg antipyrine into male Wistar rats were quantified after enzymic hydrolysis with beta-glucuronidase/aryl sulphatase. In 24 h 2.7% of the administered dose was excreted as unchanged antipyrine, 13.3% as 4-hydroxyantipyrin... | 119,355 | [
-0.2777489,
0.07713634,
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0.07736962,
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0.25323,
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0.1443484,
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0.3559287,
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0.322041,
0.2127468,
0.2754007,
0.1457686,
0.3435492,
0.00973992,
-0.080886... |
Fate of 2,5,4'-trichlorobiphenyl in rats. | 1. Following the administration of daily oral doses (1 mg/kg) of 2,5,4'-trichloro-[14C]biphenyl to rats for 14 days, the compound was rapidly excreted, only small amounts (3--4%) being stored in the organs. 2. The majority of the biphenyl was metabolized (greater than 85%) and the major metabolites excreted were identi... | 119,356 | [
-0.155748,
0.1234461,
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0.003322655,
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0.2457085,
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0.229658,
0.295487,
0.2706704,
0.1109791,
0.6251682,
0.01033688,
-0.01825... |
The stimulation of the mitochondrial respiration by citrulline synthesis. | 1. The influence of ammonia and ornithine on the oxygen uptake and the formation of citrulline was investigated with isolated rat liver mitochondria. The experiments were performed in a cytosol-like saline medium at 38 degrees C. 2. Under these conditions an increase of the respiration rate by ammonia and ornithine was... | 119,392 | [
-0.09621617,
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0.06512632,
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0.1903071,
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0.05519792,
0.0... |
[Tractional diverticulum of the urinary bladder as a component in recurring inguinal hernias]. | The tractonal diverticulum as contained in recidivating inguional hernia occur rather often. They are created most often during plastic surgical treatment most frequently in inguinal hernia repairs in which a suture partially or completely passes through the urinary bladder and fixes it to the layers of inguinal canal ... | 119,394 | [
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0.336763,
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0.2448355,
0.2533382,
-0.3521809,... |
Thrombotic thrombocytopenic purpura in early pregnancy. Remission after plasma exchange. | A 24-year-old Chinese female developed fever, fluctuating neurological and renal manifestations, microangopathic hemolytic anemia, and thrombocytopenia during the 11th week of her first pregnancy. Therapy for thrombotic thrombocytopenic purpura (TTP), initiated during the 15th week of her pregnancy, including corticost... | 119,399 | [
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0.03323418,
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0.1072179,
0.4231151,
-0.04410141... |
Anti-lymphocyte antibody levels in chronic lymphocytic leukaemia. | A radioimmunoassay for measuring levels of lymphocyte autoantibody in chronic lymphocytic leukaemia (CLL) has been developed. Antibody in the form of crude IgG was extracted from patients' sera and iodinated. The assay utilizes its cross-reactivity with other CLL cells. Levels were measured in 23 patients. The results ... | 119,416 | [
-0.2162021,
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0.1006861,
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0.3300843,
0.237214,
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... |
Comparative effects of repeated and prolonged inhalation exposure of beagle dogs and Cynomolgus monkeys to anaesthetic and subanaesthetic concentrations of enflurane and halothane. | Male and female Beagle dogs and Cynomolgus monkeys were exposed to anaesthetic (1.5 MAC) and subanaesthetic (1/100 MAC) levels of enflurane and halothane for 3 hours on alternate days for 4 weeks. One-half of the animals were killed following the last exposure and the remainder after 4 weeks of recovery. The animals' c... | 119,420 | [
-0.1506138,
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0.5356519,
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0.4942258,
-0.02425929,... |
Treatment of para-articular ossification after total hip replacement by excision and use of free fat transplants. | Six patients with para-articular ossification after total hip replacement were treated by excision and free fat tissue transplantation. The results of treatment were good and at the follow-up examinations, 2 to 8 years after the operation, a good range of movement of the hip joint was noted in all cases. It was apparen... | 119,423 | [
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0.04529379,
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0.08512577,
0.1747454,
0.1822099,
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-... |
The role of endogenous cortisol in patients with non-thyroidal illness and decreased T3 levels. | The aim of the study was to elucidate if endogenous cortisol, as previously suggested, could be involved in the mechanism behind the reduced serum T3 levels seen in euthyroid patients with various non-thyroidal illnesses. The correlation between the serum levels of T3 and cortisol was investigated in 41 hospitalized pa... | 119,429 | [
-0.2673467,
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0.1041605,
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0.1452427,
-0.08037955,
-0.06665757,
-0.3608... |
Quantitative comparison of the hominoid thalamus. I. Specific sensory relay nuclei. | Studies to date have indicated few differences in sensory perception among hominoids. Sensory relay nuclei in the dorsal thalamus--portions of the medial and lateral geniculate bodies (MGBp, LGBd) and the ventrobasal complex (VB)--in two gibbons, one gorilla, one chimpanzee and three humans were examined for anatomical... | 119,437 | [
0.004502865,
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0.04686185,
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0.07122752,
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0.2020646,
0.07394833,
0.2700167,
-0.02519564,
0.5795716,
... |
Further morphometric studies of the ulna from the Omo Basin, Ethiopia. | A reanalysis of the L40-19 fossil ulna from the Omo Basin, Ethiopia is presented. Using covariance adjustment rather than ratios to correct metric data for variations due to body size, a comparative sample reflecting 21 contemporary Anthropoid taxa, and both distribution-free and multivariate statistical procedures, th... | 119,438 | [
0.1453894,
0.1262209,
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0.2137419,
0.1707192,
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0.00814999... |
[Evaluation of urease and beta-glucosidase activity for the practical identification of mycobacteria (author's transl)]. | The urease and the beta-glucosidase for the identification of the mycobacteria were evaluated using 1,019 strains received for reference purposes in this laboratory in 1978. We found that the urease test was useful in the differential identification of BCG which, contrary to Mycobacterium bovis, gave a strong positive ... | 119,459 | [
-0.1885732,
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0.1110721,
0.1150699,
0.5189525,
0.0307695,
0.004665855... |
[Effect of moderate protein-energy malnutrition in preschool children on various biochemical parameters. Use of biochemical indicators for early detection of malnutrition]. | The efficiency of several biochemical parameters as indicators of moderate protein-energy malnutrition was investigated. 810 children aged under 5 years were studied in the forest region of southern Cameroon. The children were divided into groups of controls children and moderately malnourished children based on anthro... | 119,462 | [
0.1318933,
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0.3384872,
0.1135602,
0.01008638,
-0.1603502... |
Levels of organochlorine pesticides and polychlorinated biphenyls (PCBs) in mothers' milk collected in Osaka Prefecture from 1969 to 1976. | Long-term investigations of polychlorinated hydrocarbon levels in mothers' milk were made from 1969 to 1976. The levels of p,p'-DDE, p,p'-DDT, dieldrin and PCB in mothers' milk were within the range reported by others. However, beta-BHC(Hexachlorocyclohexane) levels in the milk were 10 times that found in non-Japanese.... | 119,494 | [
-0.2512203,
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0.7515723,
0.4283768,
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0.1662358,
-0.07176817,
-... |
Studies on the distribution of ribosomal proteins in mammalian ribosomal subunits. | Murine L5178Y cell ribosomes were dissociated into subunits either with potassium chloride in the presence of puromycin or with the chelating agent EDTA. The proteins of ribosomal subunits obtained by these different methods were compared by means of bidimensional polyacrylamide gel electrophoresis. KCl-derived 60S and... | 119,550 | [
-0.00005170083,
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0.01070571,
0.06601016,
0.2468286,
0.0007681837,
0.0800736,... |
The action of lipoxygenase-1 on furan derivatives. | Several 2,5-disubstituted furans, which are known to react with peroxyacids, singlet oxygen and other active forms of oxygen were tested as potential inhibitors, co-oxidants, or substrates for soybean lipoxygenase. The furan, 10,13-epoxy-octadeca-10,12-dienoic acid, methyl ester (IV) was converted by lipoxygenase or si... | 119,581 | [
-0.2425663,
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0.3922821,
0.08922023,
0.244286,
0.5017898,
0.3607014,
-0.2562346,
0.2... |
Serum and urine glycosidase activities in diabetes mellitus. | Plasma and urine beta-N-acetyl glucosaminidase, beta-glucuronidase and beta-galactosidase were measured in 75 diabetics and 35 control subjects. The plasma enzyme levels were significantly elevated in patients with evidence of vascular complications. There was a negative correlation between plasma enzymes and creatinin... | 119,588 | [
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0.10383,
0.1203081,
0.04066963,
0.09243447,
0.1562995,
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-0.... |
Ossicles in human menisci: report of two cases. | Two cases of ossicles in human menisci are added to the list of 18 previously reported cases. The points of interest in these cases are that in both cases multiple ossicles were incorporated in the posterior horns of the semilunar cartilages--2 in the first case and 7 in the second. In a 16-year-old girl, the posterior... | 119,601 | [
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-0.07815979,
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-0.1228209,
0.1985855,
-0.04676948,
-0.023034... |
Plasma renin activity in diabetic patients. | Plasma renin activity (PRA) in 40 diabetic patients and 42 healthy controls was investigated using the method of Pickens in modification of Serebrovskaja et al. (1967). PRA was slightly lower in the whole group of diabetes but the difference was not significant. The subgroup of 20 maturity-onset diabetics had significa... | 119,636 | [
-0.2708768,
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0.1238313,
0.02380157,
-0.1434814,
0.1122847,
... |
Genetic mapping of the coding regions for three heat-shock proteins in Drosophila melanogaster. | We describe variants of three heat-shock proteins of Drosophila melanogaster and their use to map the chromosome regions that contain the coding sequences for these proteins. All three map to a region on chromosome 3L that includes only one heat-shock puff, designated as 67B. The results imply that the genes coding for... | 119,669 | [
0.0942599,
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[Behavioral and EEG alterations with brain stem compression and effect of thyrotropin-releasing hormone (TRH) in chronic cats (author's transl)]. | Behavioral and EEG changes induced by brain stem compression and the effect of TRH were studied. The compression was given for 1 to 6 min by inflating a balloon chronically implanted on the dorsal surface of the cat brain stem in the 4th ventricle via cisterna magna. Within 10 to 36 sec after the start of the compressi... | 119,693 | [
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... |
Hurler-Scheie phenotype: a report of two pairs of inbred sibs. | Four cases from two families with dermatan sulfate mucopolysacchariduria who lack alpha-L-iduronidase in peripheral leukocytes are described. The clinical and roentgenographic features of these cases represent an intermediate phenotype between Hurler's syndrome and Scheie's syndrome, and both parents in each family are... | 119,701 | [
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Structural phosphoproteins associated with purified measles virions and cytoplasmic nucleocapsids. | Measles virions and cytoplasmic nucleocapsids were labeled with [3H]-amino acids and [32P]-orthophosphate and were purified from infected Vero cells. When analyzed by PAGE, the two capsid-associated polypeptides (VP2 -- 69,000 daltons, VP3 -- 60,000 daltons) were shown to be phosphorylated. Characterization of the phos... | 119,717 | [
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Replacement of posterior by anterior structures in the Drosophila wing caused by the mutation apterous-blot. | The recessive mutation apterous-blot in Drosophila melanogaster causes replacement of posterior wing structures by anterior ones, with variable penetrance and expressivity. Extreme transformations resemble mirror-image duplicate anterior wings as in the mutant engrailed. Anterior structures in the posterior wing only a... | 119,822 | [
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Ebola and Marburg viruses: II. Thier development within Vero cells and the extra-cellular formation of branched and torus forms. | The development of Marburg virus and the Sudanese and Zaire strains of Ebola virus in Vero cells as visualized by electron microscopy is described. Despite differences in timing, all three strains appear to pass through identical stages of development. Initially there is a large increase in nucleolus material, and vira... | 119,829 | [
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A comparison of duodenal osmolality and energy content as controlling factors of gastric emptying in the calf. | 1. The relative importance of energy content and osmolality of the duodenal chyme in the feed-back control of gastric emptying was investigated in the milk-fed calf fitted with gastric (abomasal) and duodenal re-entrant cannulae. 2. Duodenal infusion of isosmolal solutions, containing glucose, fructose or galactose, wi... | 119,845 | [
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A new case of IgE myeloma (Des) ending with renal failure. | A new case of IgE myeloma (Des), a woman aged 55, is presented. The monoclonal Ig was identified as an IgE of the kappa type. The case history is detailed. Bone lesions were absent; there were up to 12% plasma cells in the peripheral blood; therapy with cytostatic drugs could not be applied because of leuco- and thromb... | 119,859 | [
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[Prevention of Rh sensitization using anti-D immunoglobulin. (An 8 year study)]. | From July 1969 to July 1977 the authors administered 629 doses of anti D immunoglobulin to 597 women, 26 of them having received the preparation twice and 3 three times. The preparation of anti D immunoglobulin is most frequently given after delivery to Rh negative, in the ABO system compatible primiparae having given ... | 119,891 | [
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[Changes in thyroid function after application of iodinated contrast media to normal subjects (author's transl)]. | In 39 patients without thyroid disorder the influence of radiographic contrast media (Conray 60, Biligram) on the thyroid function was studied. 6 weeks after the application of the iodine compounds a significant increase of T3 in blood serum could be established being accompanied by decreased TSH level and reduced resp... | 119,903 | [
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Simultaneous determination of C1q and C3 levels in human serum by electroimmunodiffusion on agarose. | An electroimmunodiffusion method for the simultaneous determination of C1q and C3 levels in human serum is proposed. The reproducibility is good, and an excellent correlation is observed between electroimmunodiffusion and radial immunodiffusion. This simple, fast, and accurate method is suitable for clinical investigat... | 119,941 | [
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Turnover of human lactoferrin in the rabbit. | Lactoferrin turnover was studied in the rabbit with 125I- and 131I-labelled human lactoferrin. Plasma lactoferrin activity showed a rapid decrease during the first 24 h, followed by a 'final slope' with a T1/2 of about 25 h. Turnover studies after transfer of plasma from one rabbit (A) 3 h after injection to another ra... | 120,004 | [
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... |
[Notes on the transmitter histochemistry of the cortex cerebelli of rat]. | The cortex cerebelli of the normal, adult rat was investigated fluorescence histochemically by means of the paraformaldehyde method according to FALCK and HILLARP (1962) for visualization of catecholamines and a modified ninhydrin-reaction for the demonstration of GABA (PFISTER and GORNE 1978), respectively. The Purkin... | 120,097 | [
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... |
Vascularization of the endochondral layer with respect to the otic capsule. A comparative anatomical study. | The otic capsules of several species were examined morphometrically and compared with the otic capsule of man. Area, perimeter and diameter of vessels, radius of tissue cylinder, circumscribing hexagon, intervascular distance, and O2 exchange area were evaluated. A correlation between occurrence and expansion of the in... | 120,102 | [
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Comparison of effects of pentobarbital and ethanol on the neuronal activity in the posterior parietal association cortex. | The problem of this study was whether the effects produced by alcohol in the posterior parietal association cortex are specific to this drug or shared by other centrally acting depressant drugs such as barbiturates. The effect of graded doses of pentobarbital on multineuronal impulse activity was recorded with transdur... | 120,109 | [
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Neuroendocrine correlates of testosterone-induced changes in brain evoked responses to afferent input. | Evoked responses (ER) to stimulation of spermatic nerve were picked up in conscious monkeys from hypothalamic limbic and cerebral cortical regions. The effect of intravenous injection of testosterone propionate (TPss; 0.4 mg/kg) on ER was examined in the same animal. Hormone administration caused inhibition or potentia... | 120,112 | [
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Synchronization of EEG activity of male Rhesus monkeys Macaca mulatta treated with ovocyclin. | Bipolar stainless steel electrodes were stereotaxically implanted in hypothalamus and cortex of six male monkeys. The effect of intramuscular injection of estradiol dipropionate (ovocyclin) in a dose of 10 mg/d was observed on EEG activity on 3 successive days. On the first day, slow waves appeared only in preoptic and... | 120,113 | [
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[Relationships between "Mycobacterium simiae" and the "M. avium-intracellulare-scrofulaceum" complex (author's transl)]. | The 24 strains of Mycobacterium simiae described in this report were isolated from 12 black Africans, 6 from white Europeans, 5 from primates and 1 from a leprosy infected Armadillo. These strains form 3 groups having the similar morphologic and cultural properties as M. intracellulare. Two groups were similar with res... | 120,121 | [
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... |
Trypanosoma (Megatrypanum) amileari n. sp., isolated from Oryzomys eliurus (Wagner, 1845) (Rodentia-Cricetidae). | A new species of trypanosome, Trypanosoma (Megatrypanum) amilcari, is described in the present paper. This new trypanosome was found in the circulating blood of a rodent species Oryzomys eliurus (Cricetidae). Some biological observations were made. | 120,124 | [
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Distribution of membrane-bound monoamine oxidase in bacteria. | The distribution of membrane-bound monoamine oxidase in 30 strains of various bacteria was studied. Monoamine oxidase was determined by using an ammonia-selective electrode; analyses were sensitive and easy to perform. The enzyme was found in some strains of the family Enterobacteriaceae, such as Klebsiella, Enterobact... | 120,132 | [
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Human lysosomal genes: arylsulfatase A and beta-galactosidase. | The segregation of human lysosomal arylsulfatase A (ARS-A) has been evaluated in 50 primary hybrid clones derived from four separate fusions involving WBCs from two unrelated individuals and three hamster cell lines. ARS-A was expressed in the hybrids as a dimeric molecule of very similar or identical subunits. The exp... | 120,190 | [
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Characterization of the subunits of purine nucleoside phosphorylase from cultured normal human fibroblasts. | In previous communications we have demonstrated that the subunits of normal human erythrocyte purine nucleoside phosphorylase can be resolved into four major (1-4) and two minor (1p and 2p) components with the same molecular weight but different apparent isoelectric points (and net ionic charge). The existence of subun... | 120,191 | [
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Characterization of human carbonic anhydrase III from skeletal muscle. | A third form of human carbonic anhydrase (CA III), found at high concentrations in skeletal muscle, has been purified and characterized. This isozyme shows relatively poor hydratase and esterase activities compared to the red cell isozymes, CA I and CA II, but is similar to these isozymes in subunit structure (monomer)... | 120,192 | [
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... |
Genetic and cytogenetic studies of the malate dehydrogenases of Drosophila melanogaster. | Genetic and cytogenetic locations of the structural genes for the NAD-dependent malate dehydrogenases have been studied. The mitochondrial form (mMDH) is coded for by a gene (mMdh) found at 62.6 on the third chromosome and included in Df(3R)R14, which includes 90C2-91A3 in the salivary gland chromosomes. Based on its i... | 120,196 | [
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Subcellular distribution of the different platelet proteins phosphorylated on exposure of intact platelets to ionophore A23187 or to prostaglandin E1. Possible role of a membrane phosphopolypeptide in the regulation of calcium-ion transport. | Exposure of 32P-labelled human platelets to ionophore A23187 results in an increased incorporation of 32P into polypeptides with apparent mol.wts. of 47 000 (P47) and 20 000 (P20), whereas exposure to prostaglandin E1 results in increased labelling of polypeptides with apparent mol.wts. of 24 000 (P24) and 22 000 (P22)... | 120,200 | [
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0... |
Psychiatric manifestations in temporal lobe epilepsy: a controlled study. | Psychiatric disorder was studied in 62 patients with temporal lobe epilepsy (study group) and 70 patients with grand mal epilepsy (control group), both diagnosed electroencephalographically. The two groups were similar as regards age, sex, socio-economic status, duration and frequency of fits, family history and premor... | 120,210 | [
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A broth-disc technique for the assay of antibiotic synergism. | A broth-disc technique has been developed to demonstrate the antibiotic synergism of some broad-spectrum penicillins plus an aminoglycoside against Pseudomonas aeruginosa and enterococci. Utilizing the zone sites obtained from Kirby-Bauer susceptibility tests, approximate minimum inhibitory concentrations of each antib... | 120,215 | [
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0.5702586,
-... |
Dissolved organic matter utilization and oxygen uptake in algal-bacterial microcosms. | Under closed laboratory conditions, at non-limiting nutrient levels, the biomass of Anabaena variabilis, Anacystis nidulans, Chlorella pyrenoidosa, and Selanastrum capricornutum increased with increasing levels of dissolved organic matter (DOM) as a result of bacterially produced carbon dioxide (CO2) and (or) cofactors... | 120,219 | [
-0.2157752,
-0.2015365,
0.4149282,
0.4682732,
-0.1746713,
-0.2038628,
-0.2264619,
0.0414778,
-0.06627704,
-0.002874457,
0.06088499,
-0.102595,
-0.1601247,
0.0331985,
-0.1264979,
-0.1025871,
-0.4697945,
0.5180798,
-0.074136,
-0.130853,
-0.01742664,
0.5298607,
-0.1616218,
... |
Inhibition of rat hepatic microsomal cytochrome P-450 system by cobaltous chloride and reversal of inhibition by iron in vivo. | The effects of preexposure of rats to cobaltous chloride (CO) mixed in iron-sufficient (I.S) and -deficient (I.D) diets on hepatic microsomal electron transfer system was investigated. Male Sprague-Dawley rats were fed for 4 weeks on I.D diets mixed with 0, 100 and 200 ppm CO. At the end of 4 weeks three rats from each... | 120,243 | [
-0.335125,
0.1264987,
0.05547111,
0.3832673,
0.1291682,
-0.1423752,
-0.05362319,
-0.0637516,
-0.1785231,
0.02877055,
-0.01991302,
0.3624889,
0.1832977,
0.3108006,
-0.7506095,
-0.02150127,
-0.5877106,
-0.1362524,
-0.3014887,
0.2063848,
-0.2449317,
0.2119129,
0.09151511,
... |
Relevance of animal experiments to humans. | The best evidence of an adverse human health effect is a properly conducted epidemiological study. But human beings should not be the sole test animal. Properly conducted animal studies have been shown to be preductive for carcinogenicity and toxicologic responses in human populations. We need to develop more efficient... | 120,250 | [
-0.1031018,
-0.2323325,
-0.1055938,
0.0165289,
0.04682676,
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-0.3128464,
0.2079579,
0.0662159,
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0.1419259,
0.01108882,
0.3124062,
0.03010654,
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-0.1600877,
0.1938118,
-0.1675869,
0.2668613,
0.01272723,
0.3199941,
0.002250032,
... |
Biotransformation of xenobiotics in human intestinal mucosa. | Drug-metabolizing enzymes, especially monooxygenases, play a major role in biotransformation and detoxification of many foreign compounds including environmental carcinogens. Although largely localized in the liver they are also found in the small intestine, which is the portal of entry of dietary toxins. Therefore cyt... | 120,254 | [
-0.1161566,
-0.2265463,
0.02411582,
0.2085328,
0.06530704,
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0.02596211,
0.206504,
0.0658996,
0.02806477,
0.4499015,
-0.2483333,
0.09760763,
0.07504593,
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0.02949033,
-0.2769686,
0.2655666,
0.3242676,
0.0826401,
0.06214355,
0.3745178,
-0.025364,
0.14... |
Saralasin-induced renin release: its blockade by prostaglandin synthesis inhibitors in the conscious rat. | The angiotensin antagonist, saralasin, (10 and 30 mg/kg), increased serum renin activity (SRA) in normal, conscious rats from 2.7 +/- 0.4 to 16.2 +/- 3.7 and 22.5 +/- 2.4 ng/ml/hr (p less than 0.001), respectively, without markedly altering blood pressure or heart rate. Indomethacin, in a dose which inhibited the urina... | 120,320 | [
-0.05202462,
-0.14198,
-0.4290196,
-0.560388,
0.3218253,
-0.2194688,
-0.2144712,
-0.08284189,
0.08689325,
-0.3202285,
0.06662614,
0.3270477,
-0.1196938,
0.2189757,
-0.4645953,
0.1353386,
-0.4417681,
0.1236965,
0.3540422,
0.3496776,
-0.1514703,
0.1238956,
-0.04175903,
0.... |
Rehabilitating children with temporomandibular joint ankylosis. | Although the probability of ankylosis following injury of the temporomandibular joint is small, patients, especially children with temporomandibular joint ankylosis, are greatly handicapped. Of the 42 cases of ankylosis seen in our clinic, six occurred in the adult, and 36 in children under 14 years of age. Treatment i... | 120,330 | [
-0.2253501,
0.0004774243,
0.1279722,
0.0646534,
-0.006083777,
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-0.495736,
0.05335952,
-0.2039543,
-0.1659961,
0.4254254,
0.01534426,
-0.3744417,
-0.2520934,
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-0.232402,
0.2525727,
-0.1779758,
-0.104899,
0.02547841,
-0.1338652,
-0.04837487... |
Surgical treatment of chronic hyperplastic sinusitis and maxillary sinus empyema of oral/dental origin. | Twelve patients with maxillary hyperplastic sinusitis or maxillary sinus empyema of oral/dental etiology have been treated according to a modified surgical technique. The treatment was initiated by several oro-nasal irrigations and drainage facilitated by an intact semilunar hiatus. This was followed by a surgical proc... | 120,331 | [
-0.3248788,
0.125792,
0.08624797,
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0.1095787,
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0.1722134,
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0.06320963,
-0.04403314,
0.08462689,
-0.4446647,
0.361314,
-0.112569,
0.09666103,... |
Radiographic findings in 224Ra-caused dental resorptions. | Dental resorptions as a delayed effect of Thorium X (224Ra) were observed in four patients. The radiographic findings showed distinct and representative patterns. Apparently, the observed changes are typical for delayed alterations related to 224Ra-specific disturbances in the alveolar process. Degenerative and inflamm... | 120,346 | [
-0.114863,
0.02547034,
0.04669254,
-0.08051077,
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0.0163596,
0.1575932,
0.06670757,
0.3942943,
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0.2017926,
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-0.32466,
0.2039701,
0.143092,
-0.08044562,
0.4699055,
0.385613,
0.0492121,
0.18143... |
Closed vertical subcondylar osteotomy (CVSO) of the mandible. A most versatile procedure. | The closed vertical subcondylar osteotomy (CVSO) of the mandible is accomplished with a wire saw. Through a systematic approach to anatomical landmark recognition and application of a very definite series of surgical maneuvers, the surgeon can achieve optimum results with little sequelae. Because the proximal segment r... | 120,347 | [
-0.04728211,
0.2783582,
0.1723985,
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0.1280168,
-0.1383623,
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0.1420695,
0.002216649,
0.1004466,
0.2686408,
-0.1445697,
-0.4992352,
-0.4289204,
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0.3855889,
0.1950403,
-0.07386801,
0.329146,
-0.2091295,
-0.1337687,
0.... |
[Ten years experience with combination therapy for tonsillar malignancies (author's transl)]. | From 1968 to 1978, 125 patients with cancer of the tonsil have been treated by the Departments of Radiology and Otolaryngology at the University Hospital, Homburg-Saar. Although all patients were unirradiated, many had previously undergone a surgical procedure. Most of the cancers when seen were in advanced stages. The... | 120,351 | [
-0.3186462,
-0.1398809,
-0.2078713,
-0.08448951,
-0.03531935,
-0.6054725,
-0.01454207,
-0.07897347,
0.4784765,
0.4804117,
0.01024079,
-0.02001486,
0.07505251,
-0.2245569,
-0.3651422,
-0.1192585,
0.1598562,
0.02851486,
-0.3996402,
0.316183,
0.7246242,
0.01031379,
-0.111380... |
Identification of different sites of expression for spo loci by transformation of Bacillus subtilis. | Asporogenous mutants of Bacillus subtilis were rendered capable of forming heat-resistant spores by transformation with wild-type (spo+) DNA at, or near, the start of sporulation. For several mutants up to about 50% of the colonies derived from heat-resistant spores, formed as a result of the transformation, remained g... | 120,409 | [
-0.03775204,
-0.2053896,
0.08633937,
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0.1424336,
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0.06757586,
0.0978347,
0.4818682,
0.2059552,
0.09007308,
0.172285,
-0.2948552,
0.02635873,
-0.8835015,
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0.1245027,
0.04794089,
0.448567,
0.5419025,
0.4479979,
-0.2991093,
-0.... |
Electron microscopy of the morphogenesis of Bacillus subtilis bacteriophage SP3. | The capsid of Bacillus subtilis bacteriophage SP3 is assembled via a prohead intermediate which subsequently encapsulates DNA and attaches a tail. The prohead contains a ring-like core structure. The spokes which extend from the core to the inner prohead surface are thought to form a scaffold for the polymerization of ... | 120,413 | [
-0.2027959,
0.1932791,
-0.2550041,
0.04527451,
-0.06669715,
-0.1671643,
-0.1992089,
-0.1573436,
0.3357909,
0.2439025,
0.03375566,
-0.2241959,
-0.2155666,
0.03317298,
-0.3280772,
0.1504783,
0.05432136,
0.2672632,
0.09975483,
-0.1015296,
0.6461188,
0.4245609,
-0.03275185,
... |
The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey. | The mode of neuron migration from the site of their origin in the ventricular zone to area CA1 of the hippocampus was analysed with Golgi and electron microscopic methods during the first half of gestation in the foetal rhesus monkey. In the inner portion of the intermediate zone, the migrating cells have a bipolar for... | 120,417 | [
-0.02528604,
0.1506294,
-0.1935608,
-0.04524552,
0.2592527,
-0.3497076,
-0.2593281,
-0.3911609,
0.00002326828,
0.4638742,
-0.07834867,
-0.087196,
-0.006908319,
-0.05491178,
-0.05167167,
0.2265887,
-0.6444052,
0.373469,
0.06239215,
-0.01490908,
0.3183336,
0.1582601,
0.2976... |
Effect of low protein diets on free amino acids in plasma of young men: effect of wheat gluten diet. | Studies were made on alterations in plasma amino acids in young men fed a diet containing graded levels of wheat gluten. After one week on a standard diet containing 200 mgN/kg of mixed protein (animal protein content 45%), 38 young men were given a wheat gluten diet containing 170, 100, 60, 30, 15 or zero mgN/kg for 2... | 120,426 | [
-0.1547904,
0.1128347,
-0.1794346,
0.01258909,
0.1377483,
-0.131842,
-0.01345091,
0.1121178,
-0.2002391,
0.2564564,
0.02956917,
0.4121692,
0.02496234,
-0.1290818,
-0.5278663,
0.04199563,
-0.1780977,
0.107429,
-0.3307642,
0.2033673,
0.229426,
0.4529835,
0.2389077,
0.1301... |
Bartter's syndrome: 10 cases in childhood. Results of long-term indomethacin therapy. | Ten children with Bartter's syndrome are described. Their ages at diagnosis ranged from three months to 15 years and there was an equal sex distribution. A wide spectrum of severity of clinical and biochemical features was found. Hypercalcaemia, hypophosphataemia, hypercalcuria, nephrocalcinosis, rickets and urine acid... | 120,550 | [
-0.2562138,
0.03146111,
-0.05287312,
-0.2074246,
0.1826993,
-0.379649,
-0.3014269,
-0.04907834,
0.3282352,
0.1666545,
0.1838089,
0.1467155,
-0.2193357,
0.08255955,
-0.3988377,
-0.2043409,
-0.02771394,
0.08372884,
0.09767615,
0.126666,
0.463343,
-0.009383276,
-0.1479324,
... |
Radiorespirometric analysis of glucose metabolism in the rat during feeding with 3'-methyl-4-(dimethylamino)azobenzene--radiorespirometry after partial hepatectomy. | In previous papers we reported that the earlier peak time (PT) in radiorespiratory during feeding with 3'-methyl-4-(dimethylamino)azobenzene(3'-Me-DAB) is due to activation of the hexose monophosphate (HMP) pathway together with hepatic cell proliferation reflecting the toxic effects of this carcinogen. In this study, ... | 120,561 | [
0.008769219,
-0.5477426,
-0.2749,
-0.1042318,
0.143673,
-0.2498711,
0.1184491,
0.1054948,
-0.1566797,
-0.01174258,
0.2211124,
0.2486596,
-0.3527189,
0.2012652,
-0.7231451,
0.1755411,
-0.4669215,
0.5286523,
0.236256,
0.2435538,
0.3634692,
0.2946412,
-0.1317949,
-0.032387... |
Immunological responses of fluke-infected and fluke-free cattle to Salmonella dublin and other antigens. | Immune responses to heat-killed Brucella abortus strain 19 and to ovalbumin were compared in 15 fluke-infected and 15 fluke-free Friesian heifers. B abortus was injected 16 weeks and ovalbumin 19 weeks after the oral administration of 1000 metacercariae of Fasciola hepatica. Agglutinating antibody responses to B abortu... | 120,572 | [
0.03667691,
-0.7162566,
-0.05290124,
-0.07420684,
0.3196844,
-0.2695724,
-0.01492871,
-0.3265824,
-0.08865778,
0.04351107,
0.2298902,
-0.1313108,
0.1725668,
0.2519756,
0.06980389,
-0.3351913,
-0.8138217,
-0.4008324,
0.1401302,
0.2775353,
0.1526476,
0.3015232,
-0.05624187,... |
Experimental studies on the serological relationships between Yersinia enterocolitica and Brucella abortus. | Yersinia enterocolitica O9 was shown to provoke O, OH and H antibody response in calves. Brucella abortus failed to generate Yersinia H antibody response and generated Brucella O antibodies that cross-reacted with Yersinia O and OH antigens. The presence of Yersinia H agglutinins along with a higher titre of Yersinia O... | 120,574 | [
-0.1042809,
-0.403329,
0.1498236,
0.09260155,
-0.2443061,
-0.3188856,
-0.167063,
-0.03186236,
-0.06644531,
-0.02881225,
0.1560386,
0.3239077,
0.2225664,
0.09083251,
-0.4520383,
-0.3689364,
-0.5343835,
-0.1720784,
0.06662013,
-0.143491,
0.242422,
0.00289291,
-0.1175965,
... |
Heroin addiction: relationship between the plasma levels of testosterone, dihydrotestosterone, androstenedione, LH, FSH, and the plasma concentration of heroin. | Changes in sexual function and hormone levels are commonly found in subjects addicted to narcotics. In this study we examined 16 male and 3 female addicts who had been taking heroin (H) in the last year in doses higher than 150 mg/day. In these patients, who presented similar clinical problems, we assayed by RIA the pl... | 120,622 | [
-0.05356597,
0.1461644,
-0.02937657,
0.341484,
-0.03297208,
-0.2152295,
-0.1315043,
0.01429279,
-0.256036,
0.04896603,
0.4154687,
0.09299288,
-0.1126925,
0.02754329,
-0.2352684,
-0.2625075,
0.0004008275,
0.2499502,
0.1540787,
0.09554441,
0.1370369,
-0.06927793,
0.00234210... |
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