title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Association between -799C/T single nucleotide polymorphism of the MMP‑8 promoter region and thoracic aortic dissection. | Thoracic aortic dissection (TAD) is a life-threatening vascular condition, in which matrix metalloproteinases (MMPs) are involved. Since the key determinants underlying MMP action remain elusive, the present study investigated the correlation between single nucleotide polymorphisms (SNPs) in the promoter region of the ... | 25,109,362 | [
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Limitations of split-night polysomnography for the diagnosis of nocturnal hypoventilation and titration of non-invasive positive pressure ventilation in amyotrophic lateral sclerosis. | Split-night polysomnography is performed at our centre in all patients with ALS who require assessment for nocturnal hypoventilation and their response to non-invasive ventilation. The purpose of this study was to determine how successful this practice has been, reflected by whether a complete assessment was achieved b... | 25,109,404 | [
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Pterostilbene suppresses oral cancer cell invasion by inhibiting MMP-2 expression. | Polyphenol compounds, present in a wide variety of natural plants, exhibit antioxidant and free radical scavenging ability and induce apoptosis in various cancer cells. However, the effect of pterostilbene on oral cancer cell metastasis has not been clarified. The present study aimed to examine the anti-metastatic prop... | 25,109,417 | [
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One-stage surgical correction of congenital tracheal stenosis complicated with congenital heart disease in infants and young children. | Although the outcome of surgical treatment of congenital tracheal stenosis (CTS) has improved, surgical intervention for these patients, especially for those with associated congenital heart disease (CHD) remains challenging. In this report, we summarized our experience with these defects. Clinical data were collected ... | 25,109,422 | [
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Physiological and cognitive consequences of suppressing and expressing emotion in dyadic interactions. | Engaging in emotional suppression typically has negative consequences. However, relatively little is known about response-focused emotion regulation processes in dyadic interactions. We hypothesized that interacting with suppressive partners would be more threatening than interacting with expressive partners. To test p... | 25,109,434 | [
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Affinity assisted selection of antibodies for Point of Care TSH immunoassay with limited wash. | Molecular binding characteristics of several thyroid stimulating hormone (TSH) antibodies were determined for the TSH antigen, along with its closely related endogenous interfering hormones, follicle stimulating hormone (FSH), luteinizing hormone (LH) and chorionic gonadotropin (CG). This data was compared to the same ... | 25,109,443 | [
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Micro- and nano-hydroxyapatite as active reinforcement for soft biocomposites. | Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, speci... | 25,109,458 | [
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Genome-wide association study of sleep duration in the Finnish population. | Sleep duration is genetically regulated, but the genetic variants are largely unknown. We aimed to identify such genes using a genome-wide association study (GWAS) combined with RNA expression at the population level, and with experimental verification. A GWAS was performed in a Finnish sample (n = 1941), and variants ... | 25,109,461 | [
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Cellular and proteomics analysis of the endomembrane system from the unicellular Entamoeba histolytica. | Entamoeba histolytica is the protozoan parasite agent of amoebiasis, an infectious disease of the human intestine and liver. Specific active pathogenic factors are secreted toward the external milieu upon interaction of the parasite with human tissue. Trafficking dynamics and secretion of these factors is not known and... | 25,109,464 | [
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Dopamine transporter imaging using 99mTc-TRODAT-1 SPECT in Parkinson's disease. | Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients. Twenty PD pat... | 25,109,468 | [
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Organometallic nanoprobe to enhance optical response on the polycyclic aromatic hydrocarbon benzo[a]pyrene immunoassay using SERS technology. | We demonstrated the use of a new organometallic nanoprobe for competitive surface-enhanced Raman scattering (SERS) immunoassay devoted to the detection of polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP) in seawater. The nanoprobes are gold nanoparticles (GNPs) labeled by a Raman reporter, the 5,5'-d... | 25,109,469 | [
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Beneficial effects of inhaled NO on apoptotic pneumocytes in pulmonary thromboembolism model. | Lung ischemia-reperfusion injury (LIRI) may occur in the region of the affected lung after reperfusion therapy. Inhaled NO may be useful in treating acute and chronic pulmonary thromboembolism (PTE) due to the biological effect property of NO. A PTE canine model was established through selectively embolizing blood clot... | 25,109,474 | [
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Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations. | Asthma exacerbations contribute to significant morbidity, mortality and healthcare utilization. Furthermore, viral infections are associated with asthma exacerbations by mechanisms that are not fully understood. The aim of this analysis was to determine whether cytokine patterns in patients with colds could identify ri... | 25,109,477 | [
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Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy. | To investigate whether poor preoperative cardiopulmonary reserve and comorbid state dictate high-risk status and can predict complications in patients undergoing radical cystectomy (RC). In all, 105 consecutive patients with transitional cell carcinoma (TCC; stage T1-T3) undergoing robot-assisted (38 patients) or open ... | 25,109,512 | [
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Fine-grained stimulus representations in body selective areas of human occipito-temporal cortex. | Neurophysiological and functional imaging studies have investigated the representation of animate and inanimate stimulus classes in monkey inferior temporal (IT) and human occipito-temporal cortex (OTC). These studies proposed a distributed representation of stimulus categories across IT and OTC and at the same time hi... | 25,109,529 | [
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The influence of spontaneous brain oscillations on apparent motion perception. | A good example of inferential processes in perception is long-range apparent motion (AM), the illusory percept of visual motion that occurs when two spatially distinct stationary visual objects are presented in alternating sequence. The AM illusion is strongest at presentation frequencies around 3 Hz. At lower presenta... | 25,109,531 | [
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[Otoacoustic emissions as cochlear function analyser in children with language disorders]. | Speech perception that takes place in the cochlea is involved in the process of language. The objective was to describe the findings in transient otoacoustic emissions in children with language problems before and after 6 months of speech therapy. There were 17 children with language problems between 3 and 6 years of a... | 25,109,541 | [
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Proton conductivity of hexagonal and cubic BaTi1-xScxO3-δ (0.1 ≤x≤ 0.8). | BaTi1-xScxO3-δ (x = 0.1-0.8) was prepared via solid state reaction. High resolution X-ray powder diffraction was used to characterise the synthesised materials. It was found that low substitution (x = 0.1 and 0.2) of Ti(4+) for Sc(3+) gives a hexagonal perovskite structure, whereas high substitution (x = 0.5-0.7) resul... | 25,109,548 | [
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Sleep electroencephalographic characteristics of the Cynomolgus monkey measured by telemetry. | Cynomolgus monkeys are widely used as models of diseases and in pre-clinical studies to assess the impact of new pharmacotherapies on brain function and behaviour. However, the time course of electroencephalographic delta activity during sleep, which represents the main marker of sleep intensity associated with recover... | 25,109,588 | [
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Copper-catalyzed one-pot synthesis of unsymmetrical arylurea derivatives via tandem reaction of diaryliodonium salts with N-arylcyanamide. | An efficient "one-pot" approach to multiple substituted ureas from N-arylcyanamide and diaryliodonium salts has been presented. The two-step procedure involved the weak base-promoted chemoselective arylation of secondary amines with diaryliodonium and Cu-catalyzed nucleophilic addition of N-arylcyanamide with second di... | 25,109,616 | [
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Optical characterization of the antigen-antibody thin layer using the whispering gallery mode. | We immobilized an antibody (anti-β-Galactosidase) on a polystyrene microsphere by using a covalent bond, and observed the resonance peaks in the scattered light intensity spectra related to the whispering gallery mode (WGM) excitation of the microsphere. The amount and the optical parameters, i.e., thickness and refrac... | 25,109,641 | [
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A label-free fluorescence assay for trypsin based on the electron transfer between oligonucleotide-stabilized Ag nanoclusters and cytochrome c. | A label-free fluorescent assay for the detection of trypsin by using oligonucleotide-templated silver nanoclusters (Ag NCs) and cytochrome c (Cyt c) has been demonstrated. When negatively charged Ag NCs and positively charged Cyt c are mixed, they tend to form a hybrid complex, and then lead the fluorescence of Ag NCs ... | 25,109,643 | [
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A simple tool to identify elderly patients with a surgically important acute subdural haematoma. | ASDH in the elderly is a common and increasing problem, and differs in its pathophysiology from ASDH in younger people. Admitting doctors may have difficulty identifying those elderly patients whose lesions may benefit from surgery. The objective of this study was to determine whether simple neuroradiological measureme... | 25,109,659 | [
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Vision loss with bending over. | A 66-year-old African American man presented with episodic transient visual loss triggered by bending forward. The initial examination did not suggest intraocular pathology and the patient was nearly sent for vascular evaluation given his cardiovascular risk factors. Fundus photographs taken during an episode of visual... | 25,109,655 | [
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Assignment of the oxidation states of Zr and Co in a highly reactive heterobimetallic Zr/Co complex using X-ray absorption spectroscopy (XANES). | The reduced heterobimetallic complex (THF)Zr(MesNP(i)Pr2)3CoN2 (1) has been examined along with a series of structurally similar reference compounds using X-ray absorption near edge structure (XANES) spectroscopy. Complex 1 has been shown to be highly reactive, often via one-electron pathways that might be expected for... | 25,109,663 | [
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The Greek version of the 9-item European Heart Failure Self-care Behaviour Scale: a multidimensional or a uni-dimensional scale? | To evaluate the dimensionality of the Greek version of the European Heart Failure Self-care Behaviour Scale (Gr9-EHFScBS) in a Greek-Cypriot population. EHFScBS is a valid and reliable scale which is widely used for assessing heart failure (HF) patients' self-care behaviors. EHFScBS was translated into Greek and was ad... | 25,109,661 | [
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Metal binding properties of the zinc finger metallome--insights into variations in stability. | Zinc is one of the most widespread metal ions found in biological systems. Of the expected 3000 zinc proteins in the human proteome, most contain zinc in structural sites. Among these structures, the most important are zinc fingers, which are well suited to facilitate interactions with DNA, RNA, proteins and lipid mole... | 25,109,667 | [
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Transcriptome instability as a molecular pan-cancer characteristic of carcinomas. | We have previously proposed transcriptome instability as a genome-wide, pre-mRNA splicing-related characteristic of colorectal cancer. Here, we explore the hypothesis of transcriptome instability being a general characteristic of cancer. Exon-level microarray expression data from ten cancer datasets were analyzed, incl... | 25,109,687 | [
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Colonisation and competition dynamics can explain incomplete sterilisation parasitism in ant-plant symbioses. | Sterilisation of parasites prevents host reproduction, thereby diverting host resources to their own benefit. Previous theory predicts that parasites should evolve maximum virulence, yet hosts are often incompletely sterilised. Whereas prior attempts to resolve this paradox have sought evolutionary explanations, we pre... | 25,109,706 | [
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Characterization and activity of an immobilized antimicrobial peptide containing bactericidal PEG-hydrogel. | A single step immobilization-polymerization strategy of a highly active antimicrobial peptide into a soft hydrogel network on a poly(ethylene terephthalate) surface using thiol-ene chemistry is described. The bactericidal hydrogel was molecularly characterized via Coomassie and Lowry assay protein staining agents as we... | 25,109,707 | [
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Role of genetic & environment risk factors in the aetiology of colorectal cancer in Malaysia. | Colorectal cancer (CRC) is second only to breast cancer as the leading cause of cancer-related deaths in Malaysia. In the Asia-Pacific area, it is the highest emerging gastrointestinal cancer. The aim of this study was to identify single nucleotide polymorphisms (SNPs) and environmental factors associated with CRC risk... | 25,109,722 | [
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Chironomid midges as allergens: evidence from two species from West Bengal, Kolkata, India. | Arthropods of different taxonomic identity including chironomid midges are known to induce allergic response in humans. The present study was done to access two common chironomid species Chironomus circumdatus and Polypedilum nubifer for their sensitizing potential as an allergen in atopic patients and controls. Follow... | 25,109,727 | [
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Histopathological changes due to the effect of selenium in experimental cockerels. | Selenium usually acts as an antioxidant at optimal levels in the body and increased levels are toxic. In this study an attempt was made to evaluate the effect of an optimum dose (0.14 mg) of selenium on histopathological changes in experimental hypercholesterolemia in cockerels. The effect of selenium (0.14 mg) was inv... | 25,109,728 | [
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The long-term impact of diabetes on graft patency after coronary artery bypass grafting surgery: a substudy of the multicenter Radial Artery Patency Study. | The study objective was to determine the impact of diabetes on radial artery and saphenous vein graft occlusion and clinical outcomes more than 5 years after coronary artery bypass surgery in the multicenter Radial Artery Patency Study (NCT00187356). A total of 529 patients aged less than 80 years with triple-vessel di... | 25,109,754 | [
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Time to surgery and preoperative cerebral hemodynamics predict postoperative white matter injury in neonates with hypoplastic left heart syndrome. | Hypoxic-ischemic white mater brain injury commonly occurs in neonates with hypoplastic left heart syndrome (HLHS). Approximately one half of HLHS survivors will exhibit neurobehavioral symptoms believed to be associated with this injury, although the exact timing of the injury is unknown. Neonates with HLHS were recrui... | 25,109,755 | [
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Acute parvovirus B19 infection in adults: a retrospective study of 49 cases. | Our aim was to describe the epidemiologic, clinical, and laboratory characteristics of acute parvovirus B19 infection in adults. This study describes all cases of acute parvovirus B19 infection in patients older than 18 years of age who were treated at Hospital Universitario La Paz in Madrid, Spain, in 2012. Forty-nine... | 25,109,767 | [
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MicroRNA-302a inhibits adipogenesis by suppressing peroxisome proliferator-activated receptor γ expression. | The present study explored the involvement of miR-302a in adipocyte differentiation via interaction with 3'-untranslated region of peroxisome proliferator-activated receptor gamma (PPARγ) mRNA. In differentiating 3T3-L1 adipocytes, expression of miR-302a was negatively correlated with that of the adipogenic gene aP2 an... | 25,109,777 | [
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The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. | The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro... | 25,109,781 | [
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Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study. | Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, ... | 25,109,783 | [
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Retinal vessel diameter in normal-tension glaucoma patients with asymmetric progression. | To investigate the longitudinal changes in the central retinal vessel diameter in asymmetric progressive normal-tension glaucoma (NTG) patients. This study included 27 patients with bilateral NTG without any systemic vascular disease who showed glaucomatous progression in one eye at the mean follow-up of 24.3 months (r... | 25,109,787 | [
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Nanoparticulate drug delivery platforms for advancing bone infection therapies. | The ongoing surge of resistance of bacterial pathogens to antibiotic therapies and the consistently aging median member of the human race signal an impending increase in the incidence of chronic bone infection. Nanotechnological platforms for local and sustained delivery of therapeutics hold the greatest potential for ... | 25,109,804 | [
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Economic impact of multiple sclerosis in Italy: focus on rehabilitation costs. | The study estimates the cost of multiple sclerosis (MS) in Italy quantifying the impact of the rehabilitation on cost of illness. Patients with MS were enrolled at MS clinical centres, in rehabilitation units and among members with MS of the Italian MS Society across the Italy. The MS costs were captured with a questio... | 25,109,816 | [
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Spy'ing on differentiation in neuroblastoma. | Comment on: Lubanska D and Porter LA. The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population. Oncoscience. 2014; 1: 336-348. | 25,109,839 | [
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Developmental pathways activated in melanocytes and melanoma. | Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells. Melanoma cells share many characteristics with melanocyte precursors, suggesting that melanoma cells utilize the developmental programs of their normal counterpart for their own progression. The pigmentation system provides an advanta... | 25,109,840 | [
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Phenotyping: targeting genotype's rich cousin for diagnosis. | There are many current and evolving tools to assist clinicians in their daily work of phenotyping. In medicine, the term 'phenotype' is usually taken to mean some deviation from normal morphology, physiology and behaviour. It is ascertained via history, examination and investigations, and a primary aim is diagnosis. Th... | 25,109,851 | [
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Instrumental intelligent test of food sensory quality as mimic of human panel test combining multiple cross-perception sensors and data fusion. | Instrumental test of food quality using perception sensors instead of human panel test is attracting massive attention recently. A novel cross-perception multi-sensors data fusion imitating multiple mammal perception was proposed for the instrumental test in this work. First, three mimic sensors of electronic eye, elec... | 25,109,863 | [
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One-pot synthesis of magnetic colloidal nanocrystal clusters coated with chitosan for selective enrichment of glycopeptides. | Selective enrichment of glycopeptides prior to the mass spectrometry (MS) analysis is essential due to ion suppression effect during ionization caused by the co-presence of non-glycosylated peptides. Among the enrichment approaches, hydrophilic interaction liquid chromatography (HILIC) based on magnetic separation has ... | 25,109,867 | [
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The genetic variability of glycoproteins among respiratory syncytial virus subtype A in China between 2009 and 2013. | Human respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in infants and children under 5years of age. The novel genotype ON1 has a 72-nucleotide duplication, which is the largest duplicated genome portion of RSV. Whether the ON1 genotype will follow the pattern of the BA ... | 25,109,878 | [
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Home-based resistance training for older adults: a systematic review. | Home-based resistance exercise is commonly used for individuals who might not have access or the ability to use traditional resistance exercise. However, the extent to which home-based resistance exercise can improve both strength and functional ability has not been investigated in healthy older individuals using a sys... | 25,109,883 | [
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CCAAT/enhancer-binding protein β regulates interleukin-6-induced transmembrane and ubiquitin-like domain containing 1 gene expression in hepatocytes. | Transmembrane and ubiquitin-like domain containing 1 (Tmub1) protein has a negative effect on liver regeneration; however, the mechanisms of Tmub1 expression regulation are currently unknown. CCAAT/enhancer-binding protein β (C/EBPβ) is a key transcription factor associated with interleukin-6 (IL-6) in liver regenerati... | 25,109,894 | [
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Selenium treatment significantly inhibits tumor necrosis factor-α-induced cell death and tau hyperphosphorylation in neuroblastoma cells. | The hyperphosphorylation of the protein tau disrupts its normal function on regulating axonal transport and leads to the accumulation of neurofibrillary tangles (NFT), which are involved in the pathogenesis of Alzheimer's disease (AD). This study was performed to investigate whether sodium selenite may inhibit the hype... | 25,109,896 | [
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Lipopolysaccharide induces amyloid formation of antimicrobial peptide HAL-2. | Lipopolysaccharide (LPS), the important component of the outer membrane of Gram-negative bacteria, contributes to the integrity of the outer membrane and protects the cell against bactericidal agents, including antimicrobial peptides. However, the mechanisms of interaction between antimicrobial peptides and LPS are not... | 25,109,934 | [
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Assessing adaptation of the cancer kinome in response to targeted therapies. | Cancer cells are dependent on protein kinase signalling networks to drive proliferation and to promote survival, and, accordingly, kinases continue to represent a major target class for development of anti-cancer therapeutics. Kinase inhibitors nevertheless have yielded only limited success with many different malignan... | 25,109,955 | [
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About the dangers, costs and benefits of living an aerobic lifestyle. | The era in which ROS (reactive oxygen species) were simply the 'bad boys of biology' is clearly over. High levels of ROS are still rightfully considered to be toxic to many cellular processes and, as such, contribute to disease conditions and cell death. However, the high toxicity of ROS is also extremely beneficial, p... | 25,109,979 | [
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Ultra-endurance exercise: unanswered questions in redox biology and immunology. | Ultra-endurance races are extreme exercise events that can take place over large parts of a day, several consecutive days or over weeks and months interspersed by periods of rest and recovery. Since the first ultra-endurance races in the late 1970s, around 1000 races are now held worldwide each year, and more than 1000... | 25,109,991 | [
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The role of oxidative stress in the cardiovascular actions of particulate air pollution. | Air pollution has been estimated to be responsible for several millions of deaths worldwide per year, the majority of which have been attributed to cardiovascular causes. The particulate matter in air pollution has been shown impair vascular function, increase blood pressure, promote thrombosis and impair fibrinolysis,... | 25,109,994 | [
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The fate of arsenic in a river acidified by volcanic activity and an acid thermal water and sedimentation mechanism. | The Shozu-gawa river, located in the Aomori Prefecture, northern Japan, is affected by volcanic activities and acid thermal waters. The river is unique because both solid arsenic (As; as orpiment, As2S3) and dissolved As are supplied to the river from the uppermost caldera lake (Usori-ko Lake) and thermal ponds. The wa... | 25,110,041 | [
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Role of neuropeptide Y in myocardial contractility of rats during early postnatal ontogeny. | We studied the effect of neuropeptide Y in concentrations of 10(-10)-10(-6) M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropept... | 25,110,075 | [
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Myocardial serotonin during ischemia under conditions of ischemic preconditioning. | We studied the dynamics of interstitial serotonin during local myocardial ischemia under conditions of ischemic preconditioning in Wistar rats. Ischemic preconditioning increased serotonin content in the dialysate (p=0.003). During 30-min ischemia, ischemic preconditioning delayed serotonin increase just before the 20t... | 25,110,083 | [
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Rare species occupy uncommon niches. | The fact that temperate grasslands often contain upwards of 30 vascular plant species per m(2) yet these species seem to have relatively similar life histories and resource requirements has made explaining species coexistence in these communities a major focus of research. While the reduction of competition by disturba... | 25,110,113 | [
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Soluble a‑proliferation‑inducing ligand (sAPRIL), a novel serum biomarker predicting the recurrence and metastasis of pancreatic adenocarcinoma after surgery. | Pancreatic adenocarcinoma (PA) is a leading cause of adult cancer mortality, and surgery is still the best available treatment strategy. However, PA can recur at any time and has limited prognosis. It is therefore necessary to explore novel serum biomarkers of PA to allow the early diagnosis of PA. Soluble a-proliferat... | 25,110,120 | [
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Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. | Artemisinin has been demonstrated to exert beneficial effects on ventricular remodeling. The present study investigated whether artemisinin was able to decrease the ventricular fibrillation threshold (VFT) in rats following myocardial infarction (MI) and aimed to determine the possible underlying mechanisms. The rats w... | 25,110,145 | [
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Test-retest reliability for assessment of postural stability using center of pressure spatial patterns of three-dimensional statokinesigrams in young health participants. | This study investigated the test-retest reliability for assessment of postural stability using a quantitative method for identification of center of pressure (CoP) spatial patterns of three-dimensional statokinesigrams (3D-SKG). Twenty-one healthy participants (11 women, age 26.8 ± 7.2 years, body mass index 25.6 ± 5.3... | 25,110,166 | [
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Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior. | Neurons communicate primarily via action potentials that transmit information on the timescale of milliseconds. Neurons also integrate information via alterations in gene transcription and protein translation that are sustained for hours to days after initiation. Positioned between these two signaling timescales are th... | 25,110,187 | [
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Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (-)-gomisin N in human tumour cell lines. | A different behavior of the two dibenzocyclooctadiene lignans (+)-deoxyschisandrin (1) and (-)-gomisin N (2), from Schisandra chinensis fruits, was observed against two human tumour cell lines, (2008 and LoVo). These lignans inhibited cell growth in a dose-dependent manner on both cell lines, but inducing different typ... | 25,110,194 | [
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Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa. | A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis. All isolated compou... | 25,110,196 | [
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Co-immunization with virus-like particle and DNA vaccines induces protection against respiratory syncytial virus infection and bronchiolitis. | This study demonstrates that immunization with non-replicating virus-like particle (FFG VLP) containing RSV F and G glycoproteins together with RSV F DNA induced T helper type 1 antibody responses to RSV F similar to live RSV infection. Upon RSV challenge 21weeks after immunization, FFG VLP vaccination induced protecti... | 25,110,201 | [
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5'-coding sequence of the nasA gene of Azotobacter vinelandii is required for efficient expression. | The operon nasACBH in Azotobacter vinelandii encodes nitrate and nitrite reductases that sequentially reduce nitrate to nitrite and to ammonium for nitrogen assimilation into organic molecules. Our previous analyses showed that nasACBH expression is subject to antitermination regulation that occurs upstream of the nasA... | 25,110,215 | [
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Vernix caseosa peritonitis: report of two cases. | Vernix caseosa peritonitis is a rare complication caused by inflammatory response to amniotic fluid spilled into the maternal peritoneal cavity. Most cases occur after cesarean section. We discuss herein two patients, aged 33 and 29 years, who presented with vernix caseosa peritonitis seven to nine days after a cesarea... | 25,110,245 | [
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Who should receive biologic therapy for IBD?: The rationale for the application of a personalized approach. | The therapeutic approach in inflammatory bowel disease has evolved to target end-organ inflammation to heal intestinal mucosa and avoid structural damage. Objective therapeutic monitoring is required to achieve this goal. Earlier intervention with biologic therapy has been shown, indirectly, to be associated with highe... | 25,110,251 | [
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Anti-tumor necrosis factor-α monotherapy versus combination therapy with an immunomodulator in IBD. | Inflammatory bowel disease (IBD) treatment has progressed significantly over the past decade with the advent of biologics. Anti-tumor necrosis factor (anti-TNF) agents are the most widely available biologics, but the optimal approach when using them remains unclear. In this review, we highlight the currently available ... | 25,110,252 | [
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The effect of sleep restriction on neurobehavioural functioning in normally developing children and adolescents: insights from the Attention, Behaviour and Sleep Laboratory. | In the current paper, we first introduce the research themes of the attention, behaviour and sleep (ABS) laboratory, namely, sleep and ADHD, sleep and obesity, and sleep and academic performance. We then focus in on the topic to be reviewed in the current paper - the association between sleep restriction and neurobehav... | 25,110,282 | [
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[The Glivec® case: the first example of a global debate on the drug patent system]. | To describe the sequence of events involving the Glivec® case in India and to analyze the opinions generated in distinct settings. We performed a systematic search for articles concerning the imatinib (Glivec®) patent in India. We selected those sources that described the events, decisions of the authorities involved, ... | 25,110,309 | [
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Outpatient rapid 4-step desensitization for gynecologic oncology patients with mild to low-risk, moderate hypersensitivity reactions to carboplatin/cisplatin. | The primary objective of this study is to assess the efficacy and safety of an outpatient, 4-step, one-solution desensitization protocol in gynecologic oncology patients with history of mild to low-risk, moderate hypersensitivity reactions (HSRs) to platinums (carboplatin and cisplatin). This was a single institutional... | 25,110,329 | [
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Impact of obesity on surgical and oncologic outcomes in ovarian cancer. | The aim of this study is to determine the impact of obesity on surgical and oncologic outcomes after primary debulking surgery (PDS) in advanced epithelial ovarian cancer (EOC). Women with stage IIIC/IV EOC who underwent PDS with curative intent between 1/2/2003 and 12/30/2011 were included. Patient characteristics, in... | 25,110,330 | [
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mRNA transport meets membrane traffic. | Active transport and local translation of mRNAs ensure the appropriate spatial organization of proteins within cells. Recent work has shown that this process is intricately connected to membrane trafficking. Here, we focus on new findings obtained in fungal model systems. Important highlights are that RNA-binding prote... | 25,110,341 | [
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Focal chromosomal copy number aberrations in cancer-Needles in a genome haystack. | The extent of focal chromosomal copy number aberrations (CNAs) in cancer has been uncovered through technical innovations, and this discovery has been critical for the identification of new cancer driver genes in genomics projects such as TCGA and ICGC. Unlike constitutive copy number variations (CNVs), focal CNAs are ... | 25,110,350 | [
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The importance of an extensive elemental analysis of single-walled carbon nanotube soot. | Few manufacturers provide elemental analysis information on the certificates of analysis of their single-walled carbon nanotube (SWCNT) soot products, and those who do primarily perform surface sensitive analyses that may not accurately represent the bulk properties of heterogeneous soot samples. Since the accurate ele... | 25,110,357 | [
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Design and Synthesis of an Inositol Phosphate Analog Based on Computational Docking Studies. | A virtual library of 54 inositol analog mimics of In(1,4,5)P<sub3</sub has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP<sub3</sub-3KA). Chemical synthesis of the best scoring structure that also met distance criteria for 3'-OH to -P in Phosphate has been a... | 25,110,363 | [
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Markov Transition Model to Dementia with Death as a Competing Event. | This study evaluates the effect of death as a competing event to the development of dementia in a longitudinal study of the cognitive status of elderly subjects. A multi-state Markov model with three transient states: intact cognition, mild cognitive impairment (M.C.I.) and global impairment (G.I.) and one absorbing st... | 25,110,380 | [
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Guidelines for Adapting Manualized Interventions for New Target Populations: A Step-Wise Approach Using Anger Management as a Model. | The use of manual-based interventions tends to improve client outcomes and promote replicability. With an increasingly strong link between funding and the use of empirically supported prevention and intervention programs, manual development and adaptation have become research priorities. As a result, researchers and sc... | 25,110,403 | [
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Preventing infective complications in inflammatory bowel disease. | Over the past decade there has been a dramatic change in the treatment of patients with Crohn's disease and ulcerative colitis, which comprise the inflammatory bowel diseases (IBD). This is due to the increasing use of immunosuppressives and in particular the biological agents, which are being used earlier in the cours... | 25,110,408 | [
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Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer. | Advances in genomics, molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical value. Epidemiological and biological studies suggest a role for adiposity, dyslipidaemia, hyperinsulinemia, altered glucose homeostasis, and elevated expression of insulin-like... | 25,110,413 | [
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-0.110172,
-0.3691522,
-0.06423479,
0.2681149,
-0.114057,
0.0778797,
-0.08267331,
-0.196873,
0.0887503,
-0.04558627,
-0.5475422,
-0.3449609,
-0.3288695,
-0.08134099,
0.235805,
0.0683199,
0.1380547,
0.3469324,
-0.3671403,
0.... |
Controversies in the pathological assessment of colorectal cancer. | Pathologic assessment of colorectal cancer specimens plays an essential role in patient management, informing prognosis and contributing to therapeutic decision making. The tumor-node-metastasis (TNM) staging system is a key component of the colorectal cancer pathology report and provides important prognostic informati... | 25,110,416 | [
0.05310415,
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0.04063057,
0.02672032,
0.07996443,
0.08650249,
0.03094179,
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0.0540625,
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0.1874296,
0.1322984,
0.1509444,
0.2392442,
0.02877124,
... |
CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation. | To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis. The expression of CacyBP/SIP protein in gastric cancer cell lines was detected by Western blot. Immunofluorescence experiments were performed on gastric cancer c... | 25,110,433 | [
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0.06903867,
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0.01495311,
0.04369261,
0.4421973,
0.2811878,
0.4453314,
0.2558542,
... |
KISS1 methylation and expression as predictors of disease progression in colorectal cancer patients. | To examine the effect of aberrant methylation of the KISS1 promoter on the development of colorectal cancer (CRC) and to investigate reversing aberrant methylation of the KISS1 promoter as a potential therapeutic target. KISS1 promoter methylation, mRNA expression and protein expression were detected by methylation-spe... | 25,110,434 | [
0.02313332,
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0.318179,
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0.0489184,
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Imaging findings of primary gastric plasmacytoma: a case report. | Primary gastric plasmacytoma (GP) is a rare extramedullary plasmacytoma with clinical and imaging features that are common among other gastric tumors, such as gastric adenocarcinomas, gastric stromal tumors, and lymphomas. Here, we present a histologically confirmed case of primary GP examined with biphasic computed tom... | 25,110,449 | [
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0.29062,
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0.05414457,
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0... |
Veno-venous ECMO: a synopsis of nine key potential challenges, considerations, and controversies. | Following the 2009 H1N1 Influenza pandemic, extracorporeal membrane oxygenation (ECMO) emerged as a viable alternative in selected, severe cases of ARDS. Acute Respiratory Distress Syndrome (ARDS) is a major public health problem. Average medical costs for ARDS survivors on an annual basis are multiple times those dedi... | 25,110,462 | [
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0.1582357,
0.03551612,
0.2187205,
-0.1767868,
0.006806115,
-0.1069518,
-0.168566... |
Nasal high-flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV). | Aim of the study was to compare the short-term effects of oxygen therapy via a high-flow nasal cannula (HFNC) on functional and subjective respiratory parameters in patients with acute hypoxic respiratory failure in comparison to non-invasive ventilation (NIV) and standard treatment via a Venturi mask. Fourteen patient... | 25,110,463 | [
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0.002096065,
0.4044691,
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-0.1865022,
-0.07041484,
0... |
Clinical Outcomes of Posterior C2-C3 Fixation for Unstable Hangman's Fracture Compared with Posterior C1-C3 Fusion. | To verify the clinical outcomes of posterior C2-C3 fixation for unstable Hangman's fracture compared with posterior C1-C3 fixation. Twenty four patients for unstable Hangman's fracture were enrolled between July 2007 and June 2010 in this study. Thirteen patients underwent posterior C2-C3 fusion and 11 patients underwe... | 25,110,480 | [
0.06742524,
0.4919365,
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0.1975986,
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Unusual clinical presentations of cervical or lumbar dorsal ramus syndrome. | Patients with cervical (CDRS) or lumbar dorsal ramus syndrome (LDRS) are characterized by neck or low back pain with referred pain to upper or lower extremities. However, we experienced some CDRS or LDRS patients with unusual motor or bladder symptoms. We analyzed and reviewed literatures on the unusual symptoms identi... | 25,110,484 | [
0.3008153,
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0.1869127,
0.3252043,
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0... |
Intramedullary spinal cysticercosis: a case report and review of literature. | To report a case of spinal intramedullary cysticercosis in thoracic spine. A 47-year old man living in Korea referred to our hospital with both feet tingling sensation for about a year. Laboratory evaluations, including serologic tests were not helpful. Magnetic resonance imaging revealed a 1.7 cm intramedullary mass a... | 25,110,489 | [
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0.2763864,
-0.008073525,
-0.3198641,
-0.2901081,
0.2456433,
-0.000468... |
Pure spinal epidural cavernous hemangioma with intralesional hemorrhage: a rare cause of thoracic myelopathy. | Although cavernous hemangiomas occur frequently in the intracranial structures, they are rare in the spine. Most of spinal hemangiomas are vertebral origin and "pure" epidural hemangiomas not originating from the vertebral bone are very rare. Our spinal hemangioma case is extremely rare because of its "pure" epidural i... | 25,110,490 | [
0.01633126,
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0.009000584,
-0.2858972,
0.03605609,
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0.2205219,
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0.03766442,
-0.1077872,
-0.3481195,
0.1157519,
0.2531815,
0.1349882,
... |
Ant Colony Optimization Based Feature Selection Method for QEEG Data Classification. | Many applications such as biomedical signals require selecting a subset of the input features in order to represent the whole set of features. A feature selection algorithm has recently been proposed as a new approach for feature subset selection. Feature selection process using ant colony optimization (ACO) for 6 chan... | 25,110,496 | [
0.04806075,
0.0815395,
-0.1662704,
-0.3380186,
0.1025748,
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-0.5535074,
0.1553678,
0.169058,
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0.223761,
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0.4797114,
0.3101897,
0.3787023,
-0.0571232,
0.1880513,
-0.2196889,
0.0541... |
The validities and efficiencies of korean ADHD rating scale and korean child behavior checklist for screening children with ADHD in the community. | The purpose of this study is to examine the validity of primary screening tools for attention deficit hyperactivity disorder (ADHD) in a community-based sample of children using the Korean version of the Child Behavior Checklist (K-CBCL) and the Korean version of the ADHD Rating Scale (K-ARS). A large-scale community-b... | 25,110,498 | [
0.264936,
0.5228061,
0.1312217,
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0.1742138,
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0.525277,
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0.360238,
0.4023262,
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0.217967,
-0.01240137,
0.08074502,
0.0472... |
Surgical management of colorectal cancer metastases to the liver: multimodality approach and a single institutional experience. | Over the past 30 years, the treatment of metastatic colorectal cancer to the liver has undergone major changes. Once considered terminal and incurable, the prognosis of patients with colorectal hepatic metastases has seen dramatic improvements using modern multimodality therapy and now long-term survival and even cure ... | 25,110,522 | [
0.01713372,
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0.07379954,
0.4872096,
-0.09341573,
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0.2684945,
-0.0113107,
... |
Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study. | Developmental disorders of oral and written language have been linked to deficits in the processing of auditory information. However, findings have been inconsistent, both for behavioural and electrophysiological measures. In this study, we examined event-related potentials (ERPs) in 20 6- to 14-year-old children with ... | 25,110,526 | [
-0.3248801,
0.2169923,
-0.2461291,
-0.07729272,
0.1692395,
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0.07772613,
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0.2371152,
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0.3333143,
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-0.307732,
0.2326894,
0.3260193,
0.06623029,
... |
Influences on modern multifactorial falls prevention interventions and fear of falling in non-frail older adults: a literature review. | This review explores underlying features that may influence fear of falling and the effectiveness of multifactorial falls prevention programs in community dwelling non-frail adults aged 65 and older. It also examines the interrelationship between fear of falling and multifactorial falls prevention interventions. A lite... | 25,110,534 | [
-0.3110878,
0.2223408,
0.1124083,
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0.05747689,
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0.06636607,
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0.1515507,
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-0.01370322,
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-0.1302503,
0.03750702,
-0.2836695,
0.09195483,
-0.1612... |
Accuracy of unstimulated Basal serum thyroglobulin levels in assessing the completeness of thyroidectomy. | Complete excision is important for proper surgical treatment of thyroid disorders. Functional thyroid tissue can be identified based on the level of serum thyroglobulin (Tg), which is produced only by the thyroid follicular cells, and nuclear scan. Serum thyroid stimulating hormone (TSH), free thyroxin (FT4), basal (un... | 25,110,541 | [
0.1344945,
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0.08532982,
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0.1501265,
0.1087521,
0.3215356,
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0.1887975,
0.08494832,
-0.04093171,
-0.01246839,
0.2950484,
-0.4297013,... |
Chronic subdural hematoma in patients over 90 years old in a super-aged society. | Chronic subdural hematoma (CSDH) is one of the most common diseases in neurosurgical practice, particularly among aged patients. With the continuing increase in the aged population, further increases in incidence are expected. However, few studies have focused on CSDH in super-aged patients over 90 years old. We retros... | 25,110,543 | [
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0.05939867,
0.08535887,
-0.06354451,
0.1049247,
-0.2157642,
0.327178,
0.1788139... |
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