title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Does modification to the approach to contacting potential participants improve recruitment to clinical trials? | It is critical that clinical trial researchers ensure efficient and successful patient recruitment. Recruitment is often slower than expected and required sample sizes not obtained within initial funding deadlines. There is little rigorous evidence supporting ways to improve recruitment. We hypothesized making telephon... | 25,110,544 | [
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Plasma adipocytokines and antioxidants-status in Korean overweight and obese females with dyslipidemia. | It is hypothesized that obese people with dyslipidemia is more likely to have increased oxidative stress and decreased antioxidant status, in comparison with the controls who were obese without dyslipidemia. Thus, the aims of the present study were to determine the dietary intakes, plasma adipokines, and antioxidative ... | 25,110,562 | [
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Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women. | The goal of the present study was to investigate the effects of moderate caloric restriction on β-cell function and insulin sensitivity in middle-aged obese Korean women. Fifty-seven obese pre-menopausal Korean women participated in a 12-week calorie restriction program. Data on total cholesterol (TC), high density lip... | 25,110,569 | [
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Antifungal susceptibility patterns, in vitro production of virulence factors, and evaluation of diagnostic modalities for the speciation of pathogenic Candida from blood stream infections and vulvovaginal candidiasis. | Candida spp. have emerged as successful pathogens in both invasive and mucosal infections. Varied virulence factors and growing resistance to antifungal agents have contributed to their pathogenicity. We studied diagnostic accuracy of HiCrome Candida Differential Agar and Vitek 2 Compact system for identification of Ca... | 25,110,589 | [
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mTOR Signaling from Cellular Senescence to Organismal Aging. | The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly underst... | 25,110,610 | [
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Tuberculous meningitis: Diagnostic and therapeutic challenges. | Neurologists are often the first medical providers to evaluate patients with possible infectious meningitis. Knowledge of the clinical presentations and cerebrospinal fluid, microbiologic, and neuroimaging findings for different etiologies is essential to make a prompt diagnosis and initiate appropriate treatment. Tube... | 25,110,618 | [
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The Immune System and AMD. | Age related macular degeneration (AMD) is a complex, multifactorial disease that has yet to be completely understood. Significant efforts in the basic and clinical sciences have unveiled numerous areas which appear to be critical in the pathogenesis of this disease. The alternative complement pathway, immune cell activ... | 25,110,625 | [
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Habitual exercise plus dietary supplementation with milk fat globule membrane improves muscle function deficits via neuromuscular development in senescence-accelerated mice. | We examined the effects of habitual exercise plus nutritional intervention through consumption of milk fat globule membrane (MFGM), a milk component, on aging-related deficits in muscle mass and function in senescence-accelerated P1 mice. Combining wheel-running and MFGM (MFGMEx) intake significantly attenuated age-rel... | 25,110,626 | [
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Isolation and enzyme bioprospection of endophytic bacteria associated with plants of Brazilian mangrove ecosystem. | The mangrove ecosystem is a coastal tropical biome located in the transition zone between land and sea that is characterized by periodic flooding, which confers unique and specific environmental conditions on this biome. In these ecosystems, the vegetation is dominated by a particular group of plant species that provid... | 25,110,630 | [
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In vitro cytotoxicity of four calcium silicate-based endodontic cements on human monocytes, a colorimetric MTT assay. | This study was performed to evaluate the cytotoxicity of four calcium silicate-based endodontic cements at different storage times after mixing. Capillary tubes were filled with Biodentine (Septodont), Calcium Enriched Mixture (CEM cement, BioniqueDent), Tech Biosealer Endo (Tech Biosealer) and ProRoot MTA (Dentsply Tu... | 25,110,637 | [
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The impact of tobacco smoke exposure on wheezing and overweight in 4-6-year-old children. | To investigate the association between maternal smoking during pregnancy, second-hand tobacco smoke (STS) exposure, education level, and preschool children's wheezing and overweight. This cohort study used data of the KANC cohort--1,489 4-6-year-old children from Kaunas city, Lithuania. Multivariate logistic regression... | 25,110,663 | [
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Specific growth rate determines the sensitivity of Escherichia coli to lactic acid stress: implications for predictive microbiology. | This study tested the hypothesis that sensitivity of Escherichia coli to lactic acid at concentrations relevant for fermented sausages (pH 4.6, 150 mM lactic acid, aw = 0.92, temperature = 20 or 27°C) increases with increasing growth rate. For E. coli strain 683 cultured in TSB in chemostat or batch, subsequent inactiv... | 25,110,680 | [
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Acute and long-term effects of noise exposure on the neuronal spontaneous activity in cochlear nucleus and inferior colliculus brain slices. | Noise exposure leads to an immediate hearing loss and is followed by a long-lasting permanent threshold shift, accompanied by changes of cellular properties within the central auditory pathway. Electrophysiological recordings have demonstrated an upregulation of spontaneous neuronal activity. It is still discussed if t... | 25,110,707 | [
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Enoxaparin prevents steroid-related avascular necrosis of the femoral head. | Nontraumatic osteonecrosis of the femoral head is still a challenging problem in orthopedic surgery. It is responsible for 10% of the 500,000 hip replacement surgeries in the USA and affects relatively young, active patients in particular. Main reasons for nontraumatic osteonecrosis are glucocorticoid use, alcoholism, ... | 25,110,730 | [
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PEEK cages versus PMMA spacers in anterior cervical discectomy: comparison of fusion, subsidence, sagittal alignment, and clinical outcome with a minimum 1-year follow-up. | To compare radiographic and clinical outcomes after anterior cervical discectomy in patients with cervical degenerative disc disease using PEEK cages or PMMA spacers with a minimum 1-year follow-up. Anterior cervical discectomy was performed in 107 patients in one or two levels using empty PEEK cages (51 levels), Sulce... | 25,110,734 | [
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Prediction of maize single cross hybrids using the total effects of associated markers approach assessed by cross-validation and regional trials. | The present study aimed to predict the performance of maize hybrids and assess whether the total effects of associated markers (TEAM) method can correctly predict hybrids using cross-validation and regional trials. The training was performed in 7 locations of Southern Brazil during the 2010/11 harvest. The regional ass... | 25,110,752 | [
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Diagnosis of sacrococcygeal teratoma using two and three-dimensional ultrasonography: two cases reported and a literature review. | The occurrence of a fetal tumor is rare, 50% of all fetal tumors being sacrococcygeal teratomas. Prenatal diagnosis of this condition is important for the monitoring of the affected fetuses and for establishing the mode and time of delivery. We describe two cases of fetal sacrococcygeal teratoma diagnosed by 2D- and 3D... | 25,110,773 | [
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Application of nuclear magnetic resonance spectroscopy for identification of ciprofloxacin crystalluria. | This is a report describing a previously healthy young patient, who experienced crystalluria and non-cholestatic acute liver injury after a single intravenous dose of 400mg. The nuclear magnetic resonance spectra confirmed that the urinary sediment in our patient was formed by pure ciprofloxacin. The nuclear magnetic r... | 25,110,814 | [
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Promoting national blood systems in developing countries. | Over the last decade, there has been increased global attention dedicated to improving the availability, safety and use of blood in low-income and middle-income countries. These efforts have focused on a number of common objectives, such as establishing a 100% voluntary nonremunerated blood donor base and implementing ... | 25,110,817 | [
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Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina. | The aim of this study was to evaluate the influence of the most common genetic variants in methylenetetrahydrofolate reductase (MTHFR), thiopurine methyltransferase (TPMT) and glutathione-S-transferases (GSTs) on the outcome of acute lymphoblastic leukemia (ALL) treatment in Argentinean children. Two hundred and eighty... | 25,110,820 | [
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Racial and sexual minority women's receipt of medical assistance to become pregnant. | This study aimed to determine rates at which racial minority (i.e., non-White) and sexual minority (i.e., lesbian and bisexual-identified) women in the United States receive medical help to become pregnant. Income and insurance coverage discrepancies were hypothesized to mediate differences in receipt of medical help a... | 25,110,846 | [
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Richter's transformation to diffuse large B-cell lymphoma: a retrospective study reporting clinical data, outcome, and the benefit of adding rituximab to chemotherapy, from the Israeli CLL Study Group. | Richter's syndrome (RS) is the rare development of an aggressive lymphoid malignancy in a patient with pre-existing chronic lymphocytic leukemia (CLL). Data on RS is sparse and mostly derived from case reports or small series of patients and only a few larger cohorts have been published. The purpose of this large retro... | 25,110,869 | [
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Graphene oxide and laponite composite films with high oxygen-barrier properties. | The design and fabrication of oxygen barrier films is important for both fundamental and industrial applications. We prepared three different thin films composed of graphene oxide (GO) and laponite (LN), a typical low cost inorganic clay, with the GO/LN volume ratios of 1.9/0.1, 1.7/0.3 and 1.5/0.5 together with a doub... | 25,110,870 | [
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Modeling sparsely clustered data: design-based, model-based, and single-level methods. | Recent studies have investigated the small sample properties of models for clustered data, such as multilevel models and generalized estimating equations. These studies have focused on parameter bias when the number of clusters is small, but very few studies have addressed the methods' properties with sparse data: a sm... | 25,110,903 | [
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Influence of pseudophakic lens capsule opacification on spectral domain and time domain optical coherence tomography image quality. | To evaluate the influence of posterior capsule opacification (PCO) on optical coherence tomography (OCT) acquisition of macular retinal thickness (RT) and volume using time domain OCT (TD-OCT) and spectral domain OCT (SD-OCT). We studied 37 eyes of 31 patients with PCO. Each patient underwent an evaluation with TD-OCT ... | 25,110,908 | [
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Adaptive Parent Population Sizing in Evolution Strategies. | Adaptive population sizing aims at improving the overall progress of an evolution strategy. At each generation, it determines the parental population size that promises the largest fitness gain, based on the information collected during the evolutionary process. In this paper, we develop an adaptive variant of a (μ/μ, ... | 25,110,912 | [
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trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro. | This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(ii) (trans-Pt(3-af)2Cl2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against... | 25,110,914 | [
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Positive changes in self-management and disease severity following climate therapy in people with psoriasis. | The aim of this study was to investigate the impact of climate therapy on self-management in people with psoriasis. This was a prospective study of 254 adults with chronic psoriasis who participated in a 3-week climate therapy (CT) programme. The 8-scale Health Education Impact Questionnaire (heiQ) was completed at bas... | 25,110,924 | [
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Interfacial hydrogenation and deamination of nitriles to selectively synthesize tertiary amines. | A novel one-pot method has been developed for the interfacial hydrogenation of nitriles to synthesize asymmetrical tertiary amines. The active Pt NWs allow for the preparation of a series of tertiary amines in excellent yields (up to 99.0%) and a mixed solvent is vital for the adjustment of the yield. And also, the rea... | 25,110,925 | [
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Amniotic membrane transplantation in failed trabeculectomy. | To determine the efficacy and safety of amniotic membrane transplantation for trabeculectomy in patients with previous failed filtering blebs. A consecutive series of 19 eyes from 18 patients with 1 or more failed trabeculectomies were enrolled in this retrospective study. Trabeculectomy, with amniotic membrane positio... | 25,110,956 | [
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Tunable exciton funnel using Moiré superlattice in twisted van der Waals bilayer. | A spatially varying bandgap drives exciton motion and can be used to funnel energy within a solid (Nat. Photonics 2012, 6, 866-872). This bandgap modulation can be created by composition variation (traditional heterojunction), elastic strain, or in the work shown next, by a small twist between two identical semiconduct... | 25,110,970 | [
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The psychosocial impact of detention and deportation on U.S. migrant children and families. | Approximately 4.5 million U.S. citizen children live in mixed-status families, in which at least 1 family member is an unauthorized migrant and therefore vulnerable to detention and deportation from the United States (Passel & Cohn, 2011). This article critically examines the current state of the literature on the ... | 25,110,972 | [
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Novel open-framework europium silicates prepared under high-temperature and high-pressure conditions. | Two new europium silicates, Na15Eu3Si12O36 (denoted as 1) and K2EuSi4O10F (denoted as 2), were successfully synthesized under high-temperature and high-pressure conditions, and structurally characterized by single-crystal and powder X-ray diffraction (XRD). The single-crystal XRD analysis of 1 reveals that its structur... | 25,111,041 | [
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A multilocus species delimitation reveals a striking number of species of coralline algae forming Maerl in the OSPAR maritime area. | Maerl beds are sensitive biogenic habitats built by an accumulation of loose-lying, non-geniculate coralline algae. While these habitats are considered hot-spots of marine biodiversity, the number and distribution of maerl-forming species is uncertain because homoplasy and plasticity of morphological characters are com... | 25,111,057 | [
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A bistable switch in pH in urease-loaded alginate beads. | A bistable switch from a low pH (unreacted "off") state to a high pH (reacted "on") state was obtained in enzyme-loaded gel beads in response to supra-threshold substrate concentrations. | 25,111,059 | [
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Ultrahigh-resolution total correlation NMR spectroscopy. | Resolution and sensitivity are paramount for extracting detailed structural information using NMR spectroscopy. Recently developed "pure shift" techniques have greatly improved the resolution attainable in one- and two-dimensional NMR, but at a considerable cost in sensitivity. A newly introduced method, PSYCHE, greatl... | 25,111,063 | [
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Implementation of a mortality prediction rule for real-time decision making: feasibility and validity. | A previously published, retrospectively derived prediction rule for death within 30 days of hospital admission has the potential to launch parallel interdisciplinary team activities. Whether or not patient care improves will depend on the validity of prospectively generated predictions, and the feasibility of generatin... | 25,111,067 | [
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Why can't my child see 3D television? | A child encountering difficulty in watching three-dimensional (3D) stereoscopic displays could have an underlying ocular disorder. It is therefore valuable to understand the differential diagnoses and so conduct an appropriate clinical assessment to address concerns about poor 3D vision. | 25,111,097 | [
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The effect of yoga exercise on improving depression, anxiety, and fatigue in women with breast cancer: a randomized controlled trial. | Depression, anxiety, and fatigue are among the most significant problems that influence the quality of life of patients with breast cancer who receive adjuvant chemotherapy. Although evidence has shown yoga to decrease anxiety, depression, and fatigue in patients with cancer, few studies on the effects of yoga have tar... | 25,111,109 | [
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Genotype-based databases for variants causing rare diseases. | Inherited diseases are the result of DNA sequence changes. In recessive diseases, the clinical phenotype results from the combined functional effects of variants in both copies of the gene. In some diseases there is often considerable variability of clinical presentation or disease severity, which may be predicted by t... | 25,111,118 | [
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Effects of information processing speed on learning, memory, and executive functioning in people living with HIV/AIDS. | It is unclear whether or to what degree literacy, aging, and other neurologic abnormalities relate to cognitive deficits among people living with HIV/AIDS in the combined antiretroviral therapy (CART) era. The primary aim of this study was to simultaneously examine the association of age, HIV-associated motor abnormali... | 25,111,120 | [
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Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii. | Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. The complete genomes of the two phages were analyzed. Bot... | 25,111,143 | [
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Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes. | Extracellular vesicles (EVs) are cell-derived membrane vesicles. EVs contain several RNAs such as mRNA, microRNAs, and ncRNAs, but less is known of their genomic DNA (gDNA) content. It is also unknown whether the DNA cargo is randomly sorted or if it is systematically packed into specific EV subpopulations. The aim of ... | 25,111,183 | [
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IgY pharmacokinetics in rabbits: implications for IgY use as antivenoms. | This paper presents the first study of chicken IgY pharmacokinetics (PK) in rabbits. We measured IgY blood serum concentrations using a specific high sensitivity ELISA method. The fast initial component observed when studying horse Fab, F(ab')2 or IgG was absent from IgY PK. During the first 80 min of observation there... | 25,111,201 | [
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Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium. | Mutations in the ubiquitously expressed pre-mRNA processing factors 3, 8, and 31 (PRPF3, PRPF8, and PRPF31) cause nonsyndromic dominant retinitis pigmentosa in humans, an inherited retinal degeneration. It is unclear what mechanisms, or which cell types of the retina, are affected. Transgenic mice with the human mutati... | 25,111,227 | [
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Tumor-associated energy homeostasis: hepatoblastoma and neuroblastoma affect glucose and lipid metabolism as well as ghrelin, GLP-1, and PYY in nude rats. | The "metabolic competition" for nutrients between cancer cells and the patient has emerged as an important research area. For pediatric oncology, it remains unclear whether the neuroendokrine regulation of appetite by gastrointestinal hormones such as ghrelin "eat", GLP-1 (glucagon-like peptide, "do not eat"), and PYY ... | 25,111,274 | [
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Online resources in pediatric surgery: the new era of medical information. | Tele-education has the potential to facilitate rapid sharing and dissemination of current research and knowledge among pediatric surgeons around the world. Classically, the exchange of surgical research occurred via national surgical conferences, articles published in peer-reviewed journals, and textbooks. The advent o... | 25,111,279 | [
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Delirium and hypovitaminosis D: neuroimaging findings. | The authors examined the frequency of neuroimaging findings of cortical atrophy and/or cerebrovascular disease in patients with delirium with hypovitaminosis D and normal vitamin D levels. Of 32 patients with delirium with hypovitaminosis D who were neuroimaged, 91.4% had neuroimaging findings, despite only five cases ... | 25,111,282 | [
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Impact of bottom trawling on deep-sea sediment properties along the flanks of a submarine canyon. | The offshore displacement of commercial bottom trawling has raised concerns about the impact of this destructive fishing practice on the deep seafloor, which is in general characterized by lower resilience than shallow water regions. This study focuses on the flanks of La Fonera (or Palamós) submarine canyon in the Nor... | 25,111,298 | [
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Synthesis of 8-methyl-1-tetralone, a potential intermediate for (±)-platyphyllide. | An alternative method for the synthesis of the 8-methyl-1-tetralone from the commercially available 5-methoxy-1-tetralone has been developed. The transformation involves eight steps and affords an overall yield 25%. | 25,111,320 | [
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If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation. | If channels are functionally expressed in atrioventricular (AV) nodal tissue. The purpose of this study was to address whether the prototypical If inhibitor, ivabradine, at clinically safe concentrations can slow AV node conduction to reduce ventricular rate (VR) during atrial fibrillation (AF). Effects of ivabradine (... | 25,111,327 | [
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The role of the medial prefrontal cortex in regulating interanimal coordination of movements. | Rats with juvenile play experience display a greater ability in coordinating their movements with social partners than those deprived of such experience, and this may be due to the play-induced neural restructuring of the medial prefrontal cortex (mPFC). The present study investigates the role of the mPFC in interanima... | 25,111,337 | [
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(Phenoxyimidazolyl-salicylaldimine)iron complexes: synthesis, properties and iron catalysed ethylene reactions. | The reaction of 2-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol (L1), 2,4-di-tert-butyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol (L2) or 4-tert-butyl-2-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol (L3) with iron(ii) precursors produced either iron(ii) or iron(iii) complexes, depending on the nature ... | 25,111,396 | [
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Examination of the change in latent statuses in bullying behaviors across time. | Involvement in bullying and victimization has been mostly studied using cross-sectional data from 1 time point. As such, much of our understanding of bullying and victimization has not captured the dynamic experiences of youth over time. To examine the change of latent statuses in bullying and victimization, we applied... | 25,111,466 | [
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Identifying emotional and behavioral risk among gifted and nongifted children: A multi-gate, multi-informant approach. | The purpose of the current investigation was to compare 1,206 gifted and nongifted elementary students on the identification of emotional and behavioral risk (EBR) as rated by teachers and parents using a multigate, multi-informant approach to assessment. The Parent and Teacher Behavioral Assessment System for Children... | 25,111,468 | [
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The KDM5 family of histone demethylases as targets in oncology drug discovery. | There is growing evidence for a causal role of the KDM5 family of histone demethylases in human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) contribute to cancer cell proliferation, reduce the expression of tumor suppressor genes, promote the development of drug tolerance and maintain tumor-init... | 25,111,482 | [
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Multicellular architecture of malignant breast epithelia influences mechanics. | Cell-matrix and cell-cell mechanosensing are important in many cellular processes, particularly for epithelial cells. A crucial question, which remains unexplored, is how the mechanical microenvironment is altered as a result of changes to multicellular tissue structure during cancer progression. In this study, we inve... | 25,111,489 | [
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Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia. | The dopamine hypothesis suggests that excessive dopamine release results in the symptoms of schizophrenia. The purpose of this study was to elucidate the dopaminergic and noradrenergic neurons using 3-T neuromelanin magnetic resonance imaging (MRI) in patients with schizophrenia and healthy control subjects. We prospec... | 25,111,500 | [
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Synthesis and cytotoxic activity of 1-{3-[1-(5-organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues. | New highly cytotoxic 1-{3-[1-(5-organylsilyl-furan-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues (IC50 1-7 μg mL(-1)) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of Speier's catalyst. The effects of the silacycle, the element-organ... | 25,111,505 | [
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Mitigating phototoxicity during multiphoton microscopy of live Drosophila embryos in the 1.0-1.2 µm wavelength range. | Light-induced toxicity is a fundamental bottleneck in microscopic imaging of live embryos. In this article, after a review of photodamage mechanisms in cells and tissues, we assess photo-perturbation under illumination conditions relevant for point-scanning multiphoton imaging of live Drosophila embryos. We use third-h... | 25,111,506 | [
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Electromyographic activity of the diaphragm during neostigmine or sugammadex-enhanced recovery after neuromuscular blockade with rocuronium: a randomised controlled study in healthy volunteers. | The use of neuromuscular blocking agents has been associated with severe postoperative respiratory morbidity. Complications can be attributed to inadequate reversal, and reversal agents may themselves have adverse effects. To compare the electromyographic activity of the diaphragm (EMGdi) during recovery from neuromusc... | 25,111,539 | [
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Perceptions and experiences in higher education: a national study of multiracial Asian American and Latino/a students in psychology. | Demographic trends suggest increasing numbers of multiple racial heritage students attending U.S. campuses and universities, a change reflected within psychology. However, there is little empirical investigation into the educational experiences and needs of multiracials. The current study (the second in a series of stu... | 25,111,546 | [
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The Pacific Identity and Wellbeing Scale-Revised (PIWBS-R). | We develop and validate a revised version of the Pacific Identity and Wellbeing Scale (the PIWBS-R). This revision extends the original 5-factor PIWBS model to include a sixth subscale assessing Cultural Efficacy (CE). The definition and item content for CE was based on a synthesis of research on self-efficacy and Paci... | 25,111,555 | [
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Increased low-frequency oscillation amplitude of sensorimotor cortex associated with the severity of structural impairment in cervical myelopathy. | Decreases in metabolites and increased motor-related, but decreased sensory-related activation of the sensorimotor cortex (SMC) have been observed in patients with cervical myelopathy (CM) using advanced MRI techniques. However, the nature of intrinsic neuronal activity in the SMC, and the relationship between cerebral... | 25,111,566 | [
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Preparation and multiple antitumor properties of AuNRs/spinach extract/PEGDA composite hydrogel. | In this study, a novel composite hydrogel that contains spinach extract (SE), gold nanorods (AuNRs), and poly(ethylene glycol) double acrylates (PEGDA) is prepared through a one-step in situ photopolymerization under noninvasive 660 nm laser irradiation for localized antitumor activity. SE plays a role as a photoinitia... | 25,111,567 | [
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Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. | The purpose of this study was to investigate oxidative stress as a mechanism of preterm birth in human subjects; we examined associations between urinary biomarkers of oxidative stress that were measured at multiple time points during pregnancy and preterm birth. This nested case-control study included 130 mothers who ... | 25,111,586 | [
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Circulating tumour cells in metastatic head and neck cancers. | Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with 650,000 new cases p/a worldwide. HNSCC causes high morbidity with a 5-year survival rate of less than 60%, which has not improved due to the lack of early detection (Bozec et al. Eur Arch Otorhinolaryngol. 2013;270: 2745-9). Metastatic d... | 25,111,594 | [
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Contaminants of emerging concern in fresh leachate from landfills in the conterminous United States. | To better understand the composition of contaminants of emerging concern (CECs) in landfill leachate, fresh leachate from 19 landfills was sampled across the United States during 2011. The sampled network included 12 municipal and 7 private landfills with varying landfill waste compositions, geographic and climatic set... | 25,111,596 | [
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Diagnosis, mechanisms and treatment of complex regional pain syndrome. | The incidence and disease course of complex regional pain syndrome (CRPS) has been unclear until recently. This was due to inconsistent diagnostic criteria used in previous studies and a lack of large-scale prospective datasets. Multiple mechanisms of CRPS have been suggested, and recent research has begun to explain h... | 25,111,604 | [
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Outline-based morphometrics, an overlooked method in arthropod studies? | Modern methods allow a geometric representation of forms, separating size and shape. In entomology, as well as in many other fields involving arthropod studies, shape variation has proved useful for species identification and population characterization. In medical entomology, it has been applied to very specific quest... | 25,111,609 | [
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Renal response to L-arginine in diabetic rats. A possible link between nitric oxide system and aquaporin-2. | The aim of this study was to evaluate whether L-Arginine (L-Arg) supplementation modifies nitric oxide (NO) system and consequently aquaporin-2 (AQP2) expression in the renal outer medulla of streptozotocin-diabetic rats at an early time point after induction of diabetes. Male Wistar rats were divided in four groups: C... | 25,111,608 | [
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Spread and predominance in Japan of novel G1P[8] double-reassortant rotavirus strains possessing a DS-1-like genotype constellation typical of G2P[4] strains. | Rotavirus is a major cause of severe gastroenteritis in children <5 years of age worldwide, and two, live attenuated rotavirus vaccines are globally available. As rotavirus vaccines are introduced into national immunization programs, there is an increasing need to monitor circulating wild-type strains. However, few ... | 25,111,613 | [
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Long-term IFN-γ and IL-2 response for detection of latent tuberculosis infection in healthcare workers with discordant immunologic results. | Discordant results between the interferon-gamma release assays (IGRAs) and tuberculin skin test (TST) are common in latent tuberculosis infection (LTBI). We evaluated whether the measurement of IFN-γ and interleukin (IL)-2T-cell responses, after prolonged Mycobacterium tuberculosis-specific antigen stimulation, can be ... | 25,111,618 | [
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Personality structure in the domestic cat (Felis silvestris catus), Scottish wildcat (Felis silvestris grampia), clouded leopard (Neofelis nebulosa), snow leopard (Panthera uncia), and African lion (Panthera leo): a comparative study. | Although the study of nonhuman personality has increased in the last decade, there are still few studies on felid species, and the majority focus on domestic cats. We assessed the structure of personality and its reliability in five felids-domestic cats, clouded leopards, snow leopards, African lions, and previous data... | 25,111,629 | [
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Noninvasive ventilation for patients with hypoxemic acute respiratory failure. | Noninvasive ventilation (NIV) has an established efficacy to improve gas exchange and reduce the work of breathing in patients with hypoxemic acute respiratory failure. The clinical efficacy in terms of meaningful outcome is less clear and depends very much on patient selection and assessment of the risks of the techni... | 25,111,645 | [
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Noninvasive ventilation in withdrawal from mechanical ventilation. | Patients with chronic airflow obstruction and difficult or prolonged weaning are at increased risk for prolonged invasive mechanical ventilation (IMV). Several randomized controlled trials mainly conducted in patients who had pre-existing lung disease have shown that the use of noninvasive ventilation (NIV) to advance ... | 25,111,647 | [
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Synthesis of cyclic imides from nitriles and diols using hydrogen transfer as a substrate-activating strategy. | An atom-economical and versatile method for the synthesis of cyclic imides from nitriles and diols was developed. The method utilizes a Ru-catalyzed transfer-hydrogenation reaction in which the substrates, diols, and nitriles are simultaneously activated into lactones and amines in a redox-neutral manner to afford the ... | 25,111,669 | [
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The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. | MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including ... | 25,111,671 | [
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Cluster size effects of platinum oxide as active sites in hydrogen evolution reactions. | The successful design of photocatalytic hydrogen generation from water relies on a thorough understanding of the role of cocatalyst. The photoreactivity was studied as a function of the cluster size of the oxidized platinum cocatalyst. The maximum turnover frequency is found on the smallest-sized cocatalyst. This effec... | 25,111,675 | [
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Posterior scleral reinforcement and vitrectomy for myopic foveoschisis in extreme myopia. | To evaluate the effect of surgical posterior scleral reinforcement in extremely myopic patients (axial length ≥30 mm) with myopic foveoschisis. The retrospective interventional case series study included patients with an axial length ≥30 mm, posterior scleral staphyloma, and myopic foveoschisis, who were treated either... | 25,111,687 | [
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Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury. | Aminoglycoside-induced nephrotoxicity is one of the prevalent causes of acute kidney injury (AKI). Oxidative stress-mediated apoptosis of renal tubular cells is known to be a major mechanism of renal injury. Red ginseng extract (RGE) has been reported to possess antioxidant and immune-modulatory activities. We investig... | 25,111,692 | [
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Male Asian international students' perceived racial discrimination, masculine identity, and subjective masculinity stress: a moderated mediation model. | This study examined male Asian international college students' perceptions of racial discrimination, subjective masculinity stress, centrality of masculine identity, and psychological distress by testing a moderated mediation model. Participants were 160 male Asian international college students from 2 large public uni... | 25,111,707 | [
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-0.2775022,
0.03883205,
-0.3541584,
-0.3371845,
-0.1829448,
-0.06689488,
-0.3208039,
-0.3880146,
0.3782876,
0.01817823,
-0.2738312,
-0.09580775,
0.2991011,
-0.01397733,
0... |
Twinship as a resource: zygosity- and gender-based comparison of twins' attitudes toward twinship. | Aiming to perform the first sociological survey of Hungarian twins, our main question was whether being a twin has positive consequences on one's life. Adult twins completed our questionnaire at three Hungarian summer twin festivals, in hospitals during medical twin studies, and on some websites online. Data represent ... | 25,111,726 | [
0.07998262,
0.1316543,
0.1485069,
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0.4261406,
0.1505105,
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Recognition and repair of chemically heterogeneous structures at DNA ends. | Exposure to environmental toxicants and stressors, radiation, pharmaceutical drugs, inflammation, cellular respiration, and routine DNA metabolism all lead to the production of cytotoxic DNA strand breaks. Akin to splintered wood, DNA breaks are not "clean." Rather, DNA breaks typically lack DNA 5'-phosphate and 3'-hyd... | 25,111,769 | [
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0.06416079,
0.2395852,
0.3205592,
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0.2541696,
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Evolutionary stability in the asymmetric volunteer's dilemma. | It is often assumed that in public goods games, contributors are either strong or weak players and each individual has an equal probability of exhibiting cooperation. It is difficult to explain why the public good is produced by strong individuals in some cooperation systems, and by weak individuals in others. Viewing ... | 25,111,781 | [
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0.07600431,
0.2683384,
0.08038104,
0.2027697,
0.04530929,
-0.08402269... |
A four-stage hybrid model for hydrological time series forecasting. | Hydrological time series forecasting remains a difficult task due to its complicated nonlinear, non-stationary and multi-scale characteristics. To solve this difficulty and improve the prediction accuracy, a novel four-stage hybrid model is proposed for hydrological time series forecasting based on the principle of 'de... | 25,111,782 | [
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Voice prosthetic biofilm formation and Candida morphogenic conversions in absence and presence of different bacterial strains and species on silicone-rubber. | Morphogenic conversion of Candida from a yeast to hyphal morphology plays a pivotal role in the pathogenicity of Candida species. Both Candida albicans and Candida tropicalis, in combination with a variety of different bacterial strains and species, appear in biofilms on silicone-rubber voice prostheses used in larynge... | 25,111,806 | [
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0.3410748,
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0.169... |
Skeletal analysis and differential gene expression in Runx2/Osterix double heterozygous embryos. | The transcription factors, Runx2 and Osterix (Osx), act downstream in the BMP2 pathway, and they are essential for osteoblast differentiation and bone formation. While Runx2 expression is normal in Osx-null mice, Osx is not expressed in Runx2-null mice, indicating that Osx acts downstream of Runx2 during bone formation... | 25,111,820 | [
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0.4644222,
0.2099659,
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Odor tracking in sharks is reduced under future ocean acidification conditions. | Recent studies show that ocean acidification impairs sensory functions and alters the behavior of teleost fishes. If sharks and other elasmobranchs are similarly affected, this could have significant consequences for marine ecosystems globally. Here, we show that projected future CO2 levels impair odor tracking behavio... | 25,111,824 | [
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0.4173445,
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Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation. | Diabetic patients have increased levels of advanced glycation end products (AGEs) and the role of AGEs in regulating cancer cell proliferation is unclear. Here, we found that treating colorectal and liver cancer cells with AGEs promoted cell proliferation. AGEs stimulated both the expression and activation of a key tra... | 25,111,846 | [
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0.01018749,
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0.003087138,
0.2574541,
0.1564587,
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Electrophysiology-based detection of emergency braking intention in real-world driving. | The fact that all human action is preceded by brain processes partially observable through neuroimaging devices such as electroencephalography (EEG) is currently being explored in a number of applications. A recent study by Haufe et al (2011 J. Neural Eng. 8 056001) demonstrates the possibility of performing fast detec... | 25,111,850 | [
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0.134992,
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0.12623... |
Ex vivo protective effects of nicotinamide and 3-aminobenzamide on rat synaptosomes treated with Aβ(1-42). | Alzheimer's disease (AD) is the most common form of dementia and is characterized by the presence of senile plaques and neurofibrillary tangles, along with synaptic loss. The underlying mechanisms of AD are not clarified yet, but oxidative stress and mitochondrial dysfunction are important factors. Overactivation of po... | 25,111,857 | [
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0.1600111,
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0.02965776,
0.4240784,
0.1110338,
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The energy balance in cancer cachexia revisited. | To review new putative mechanisms involved in the pathophysiology of a disturbed energy balance in cancer cachexia, which can lead to novel targets for clinical cachexia management. In the context of rapid developments in tumour treatment with potential systemic consequences, this article reviews recent data on energy ... | 25,111,867 | [
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0.3884559,
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Physical activity and the perceived neighbourhood environment - looking at the association the other way around. | The association between physical activity (PA) and variables of the perceived environment mainly originate from cross-sectional studies that introduced the idea that the environment influences the PA level of residents. However, the direction of cause and effect has not been solved with finality. The aim of this study ... | 25,111,877 | [
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0.09414376,
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0.2989462,
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Dissecting the global variation of gene expression for the functional interpretation of transcriptome data. | To perform their biological functions, individual genes exhibit varying ranges of expression levels. Thus, considering the intrinsic variability of gene expression can improve geneset-based functional analyses which are typically used to interpret transcriptome data. Through the extensive quantitative analysis of the e... | 25,111,883 | [
-0.1153712,
0.2348723,
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0.01900354,
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0.05849288,
0.1592796,
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... |
Preparation and electric property of polysilsesquioxane thin films incorporating carbazole groups. | New silsesquioxane incorporating a carbazole groups (PCTSQ) has been synthesized by a click thiol-ene reaction and a subsequent sol-gel reaction. To evaluate the electric property of this hybrid, diode devices have been fabricated by using PCTSQ thin film by spin-coating onto n-type ZnO film prepared by the electrodepo... | 25,111,904 | [
0.1135129,
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0.1269149,
0.3130156,
0.09427528,
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The association of state legal mandates for data submission of central line-associated bloodstream infections in neonatal intensive care units with process and outcome measures. | To determine the association between state legal mandates for data submission of central line-associated bloodstream infections (CLABSIs) in neonatal intensive care units (NICUs) with process and outcome measures. Cross-sectional study. National sample of level II/III and III NICUs participating in National Healthcare ... | 25,111,921 | [
0.339074,
0.004614851,
0.0273577,
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0.2432885,
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0.04609941,
0.1425984,
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0.1544564,
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... |
Transient osteoporosis of pregnancy of the bilateral hips in twin gestation: a case series. | Transient osteoporosis of pregnancy has been described as a rare, self-limiting disease of unclear etiology that presents as severe pain, which typically affects pregnant women in their third trimester. We describe 3 cases of primigravid pregnant women with twin gestation who reported unilateral hip pain and who were d... | 25,111,945 | [
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0.1635253,
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Reduction of physiological effects in fNIRS waveforms for efficient brain-state decoding. | This paper presents a methodology for online estimation of brain activities with reduction in the effects of physiological noises in functional near-infrared spectroscopy signals. The input-output characteristics of a hemodynamic response are modeled as an autoregressive moving average model together with exogenous phy... | 25,111,978 | [
0.1637607,
0.4090251,
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0.05442163,
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0.0581498,
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0.04513127,
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Coronary artery disease and 10-year outcome after hospital admission for heart failure with preserved and with reduced ejection fraction. | The prognostic impact of coronary artery disease (CAD) in heart failure is debated. Whereas causes of death have been well described in patients with cardiomyopathy, little is known about how CAD influences causes of death in heart failure with preserved ejection fraction (HFPEF). We undertook a 10-year study and analy... | 25,111,982 | [
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0.002118813,
0.4842231,
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0.1874065,
0.08257452,
0.2027039,
-0.20... |
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