title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Determination of organochlorines, polychlorinated biphenyls and polybrominated diphenyl ethers in human hair: estimation of external and internal exposure. | A novel method was developed for the analysis of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in human hair samples. External contaminants of hair were extracted with acetone under sonication, while washed hair was further hydrolyzed in formic acid and ac... | 25,113,219 | [
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Systematic review of diplommatinid land snails (Caenogastropoda, Diplommatinidae) endemic to the Palau Islands. (1) Generic classification and revision of Hungerfordia species with highly developed axial ribs. | Diplommatinidae is a family of terrestrial caenogastropod snails that shows extensive species diversity and endemic radiation within the Palau (Belau) Islands. In this paper, we revised the taxonomy of Palauan endemic diplommatinids based on the comparative morphology of shell, operculum, radula, and genitalia. Althoug... | 25,113,222 | [
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Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center. | Therapeutic resistance remains the principal problem in acute myeloid leukemia (AML). We used area under receiver-operating characteristic curves (AUCs) to quantify our ability to predict therapeutic resistance in individual patients, where AUC=1.0 denotes perfect prediction and AUC=0.5 denotes a coin flip, using data ... | 25,113,226 | [
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A low computational cost algorithm for REM sleep detection using single channel EEG. | The push towards low-power and wearable sleep systems requires using minimum number of recording channels to enhance battery life, keep processing load small and be more comfortable for the user. Since most sleep stages can be identified using EEG traces, enormous power savings could be achieved by using a single chann... | 25,113,231 | [
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Chaotic oscillation and random-number generation based on nanoscale optical-energy transfer. | By using nanoscale energy-transfer dynamics and density matrix formalism, we demonstrate theoretically and numerically that chaotic oscillation and random-number generation occur in a nanoscale system. The physical system consists of a pair of quantum dots (QDs), with one QD smaller than the other, between which energy... | 25,113,239 | [
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Incidence and risk factors for AIDS-related mortality in HIV patients in China: a cross-sectional study. | To estimate the incidence and risk factors for mortality in HIV-1-infected patients in China. Information on AIDS-related deaths was collected from the Chinese Center for Disease Control and Prevention's Disease Surveillance Information Reporting System and AIDS Prevention and Control Information System. A total of 379... | 25,113,245 | [
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Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study. | Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its impact on clinic... | 25,113,260 | [
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Impact locations and concussion outcomes in high school football player-to-player collisions. | Little research has examined concussion outcomes in terms of impact location (ie, the area on the head in which the impact occurred). This study describes the epidemiology of concussions resulting from player-to-player collision in high school football by impact location. National High School Sports-Related Injury Surv... | 25,113,292 | [
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Biology of advanced uveal melanoma and next steps for clinical therapeutics. | Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes. Patients diagnosed with a primary uveal melanoma can be stratified for risk of metastasis by cytogenetics or... | 25,113,308 | [
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Versatile Cu(I)/Pd(0) dual catalysis for the synthesis of quaternary α-allylated carbonyl compounds: development, mechanistic investigations and scope. | We report herein a versatile cooperative dual catalysis reaction based on a Cu(I)/Pd(0) system. Mechanistic investigation shows that every component plays a crucial role in determining the reaction outcome. The reaction is successfully extended to various substrates; such as α,β-unsaturated ketones, malonates and couma... | 25,113,317 | [
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One pot synthesis of nanoscale phase-segregated PdPt nanoarchitectures via unusual Pt-doping induced structural reorganization of a Pd nanosheet into a PdPt nanotent. | Pt-doping of an ultrathin Pd nanosheet results in the unprecedented structural rearrangement of a Pd nanosheet into a PdPt nanotent structure, in which a tripod stands on a triangular nanosheet. Further growth of Pt phase on this nanotent structure is dependent on the presence of surface-stabilizing CO molecules, leadi... | 25,113,322 | [
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[Clinical features and prurigo nodularis in nephrogenic pruritus]. | Nephrogenic pruritus (NP) is a well-known associated symptom in patients with chronic renal failure. The aim of the present study was to make a detailed dermatological analysis including distribution of excoriations and their correlation with pruritus characteristics. Data on a total of 17 patients with NP (14 males, m... | 25,113,331 | [
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Morphological variation and affinities of the poorly known snake Atractus caxiuana (Serpentes: Dipsadidae) . | Atractus caxiuana was recently described based on three specimens (two males and one female) from the Floresta Nacional de Caxiuanã, municipality of Melgaço, state of Pará, in the eastern portion of the Brazilian Amazon. Apart from the type series, no additional samples are known for the species. In this study, we repo... | 25,113,336 | [
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World synopsis of described species of the genus Platypygus Loew (Diptera: Mythicomyiidae: Platypyginae). | The taxonomy of the genus Platypygus Loew is summarized, previously described species are reviewed based on examination of types, and a key to known species of the genus worldwide is presented. All previously described species are diagnosed and illustrated. The male genitalia of P. ridibundus (Costa) and female genital... | 25,113,345 | [
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Description of Culicoides paradoxalis sp. nov. from France and Portugal (Diptera: Ceratopogonidae). | A new species, Culicoides paradoxalis Ramilo and Delécolle (Diptera: Ceratopogonidae), is described from specimens collected in France (Corsica and southeast region) and Portugal. This species resembles Culicoides lupicaris Downes and Kettle, and can be distinguished from this species and from Culicoides newsteadi Aust... | 25,113,346 | [
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Two new species of scale mites (Acari: Pterygosomatidae) parasitizing Agama agama (Sauria: Agamidae) from Kenya. | Two new species of pterygosomatid mites Pterygosoma garissi sp. nov. and P. fragilis sp. nov. (Acari: Pterygosomatidae) are described from the agamid lizard Agama agama (Sauria: Agamidae) from Kenya. P. garissi sp. nov. is similar to P. annectans Jack, 1962 but in the new species the peripheral setae are slightly expan... | 25,113,347 | [
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Review of the genus Dolichosciara Tuomikoski (Diptera, Sciaridae) from China. | The genus Dolichosciara from China is reviewed and 17 species are recognized. Among them, eight new species, D. sparsula sp. nov., D. gracilenta sp. nov., D. oxyacantha sp. nov., D. scrobiculata sp. nov., D. tumidula sp. nov., D. rectospinosa sp. nov., D. multisetosa sp. nov. and D. qingliangfengana sp. nov. are descri... | 25,113,353 | [
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Endogean and cavernicolous Coleoptera of the Balkans. XII. New species of Paramaurops Jeannel, 1948 (Coleoptera: Staphylinidae: Pselaphinae) from Macedonia. | The new species of the tribe Amauropini, Paramaurops vonickai n. sp. is described from Macedonia. | 25,113,357 | [
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Two interstitial species of the genus Semicytherura (Crustacea: Ostracoda) from Japan, with notes on their microhabitats. | A new interstitial ostracod, Semicytherura uzushio sp. nov., is described from the southwest of Japan, and the details of the carapace characters of Semicytherura mukaishimensis Okubo, 1980 are redescribed. Semicytherura uzushio and S. mukaishimensis live interstitially in the intertidal and infralittoral zones, respec... | 25,113,360 | [
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Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: the Korean Cancer Prevention Study-II. | The incidence of colorectal cancer (CRC) is steadily increasing worldwide. Numerous studies have demonstrated that diabetes mellitus is related to an increased risk of CRC; however, the association between impaired fasting glucose and CRC is unclear. Therefore, we evaluated the correlation between fasting serum glucose... | 25,113,383 | [
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The advances and perspectives of recombinant protein production in the silk gland of silkworm Bombyx mori. | The silk gland of silkworm Bombyx mori, is one of the most important organs that has been fully studied and utilized so far. It contributes finest silk fibers to humankind. The silk gland has excellent ability of synthesizing silk proteins and is a kind tool to produce some useful recombinant proteins, which can be wid... | 25,113,390 | [
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The hidden history of the snowshoe hare, Lepus americanus: extensive mitochondrial DNA introgression inferred from multilocus genetic variation. | Hybridization drives the evolutionary trajectory of many species or local populations, and assessing the geographic extent and genetic impact of interspecific gene flow may provide invaluable clues to understand population divergence or the adaptive relevance of admixture. In North America, hares (Lepus spp.) are key s... | 25,113,393 | [
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GlycoMaster DB: software to assist the automated identification of N-linked glycopeptides by tandem mass spectrometry. | Glycosylation is one of the most commonly observed post-translational modifications (PTMs) in eukaryotes. It is believed that more than 50% eukaryotic proteins are glycosylated. To reveal the biological functions of protein-linked glycans involved in numerous biological processes, the high-throughput identification of ... | 25,113,421 | [
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Dehydrative cross-coupling reactions of allylic alcohols with olefins. | The direct dehydrative activation of allylic alcohols and subsequent cross-coupling with alkenes by using palladium catalyst containing a phosphoramidite ligand is described. The activation of the allyl alcohol does not require stoichiometric additives, thus allowing clean, waste-free reactions. The scope is demonstrat... | 25,113,437 | [
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Rubisco catalytic properties optimized for present and future climatic conditions. | Because of its catalytic inefficiencies, Rubisco is the most obvious target for improvement to enhance the photosynthetic capacity of plants. Two hypotheses are tested in the present work: (1) existing Rubiscos have optimal kinetic properties to maximize photosynthetic carbon assimilation in existing higher plants; (2)... | 25,113,451 | [
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Review of the Eulamprotes wilkella species-group based on morphology and DNA barcodes, with descriptions of new taxa (Lepidoptera, Gelechiidae). | The Eulamprotes wilkella species-group is revised based on morphological characters and on DNA barcodes of the mtCOI (Cytochrome c Oxidase 1) gene. Adult morphology combined with sequence information for 9 species supports the existence of 12 species, 7 of which are described as new to science: E. mirusella Huemer &... | 25,113,469 | [
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New records of Recent Brachiopoda from the Red Sea with a description of a new species . | A revised checklist of 14 Recent brachiopod species from Egypt and the Sudan in the Red Sea has been compiled. New records of Minutella minuta (Cooper), Thecidellina blochmanni Dall and Argyrotheca somaliensis Cooper are described and a new species Argyrotheca cooperi is erected for specimens with few but very strong c... | 25,113,473 | [
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Revision of the genus Ortopla Walker, [1859] with description of two new species from Southeast Asia (Lepidoptera, Noctuidae, Pantheinae). Revision of Pantheinae, contribution X. | The pantheine genus Ortopla Walker, [1859] 1858 is revised. Two new species, Ortopla witti sp. n. from the Philippines and O. longiuncus sp. n. from Nepal, Vietnam, Thailand, Myanmar and South China are described. The name O. commutanda Warren, 1891 (syn. n.) is synonymised with O. iarbasalis Walker, [1859] 1858. The d... | 25,113,477 | [
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The male and larvae of Nigritothrips longistylosus (Thysanoptera, Thripidae) with observations on its biology. | The male and larvae of Nigritothrips longistylosus (Priesner) are described for the first time. The life cycle, seasonal abundance, natural enemies and host plant relationships are described. This is the first record of this species from the Iberian Peninsula. | 25,113,493 | [
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Two new species of the leafhopper genus Anidiocerus (Hemiptera: Cicadellidae: Idiocerinae) from China. | Two new species of Anidiocerus from China, A. brevispinus Xue & Zhang sp. nov. and A. longimus Xue & Zhang sp. nov. are described and illustrated, and A. variabilis Maldonado-Capriles, 1976 is placed as a senior synonym of A. flavidus Cai & Shen, 1998, syn. nov. A redescription of the genus is provided toge... | 25,113,491 | [
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XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer. | Head and neck cancer (HNC), one of the most common cancers worldwide, frequently involves mutation of the TP53 gene and dysregulation of the p53 pathway. Overexpression of MDM2 or MDM4 inactivates the tumor-suppressive function of p53. Restoration of p53 function that counteracts these p53 repressors can lead to in viv... | 25,113,507 | [
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The critical role of the operating conditions on the Fenton oxidation of 2-chlorophenol: assessment of PCDD/Fs formation. | This work assesses the influence of the operating conditions H2O2 dose (20 or 100% of the stoichiometric amount), temperature (20 or 70°C), and the presence of chloride in the oxidation medium in the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) during Fenton treatment of aqueous samples of... | 25,113,517 | [
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The effects of dexmedetomidine administration on the pulmonary artery pressure and the transpulmonary pressure gradient after the bidirectional superior cavopulmonary shunt. | The hemodynamic effects of dexmedetomidine (DEX) on pulmonary artery pressure (PAP) are not fully understood in patients with a single-ventricle physiology. The objective of this retrospective study was to characterize the effect of perioperative DEX infusion on PAP and the transpulmonary pressure gradient after a bidi... | 25,113,519 | [
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Development of a charge adjustment model for cardiac catheterization. | A methodology that would allow for comparison of charges across institutions has not been developed for catheterization in congenital heart disease. A single institution catheterization database with prospectively collected case characteristics was linked to hospital charges related and limited to an episode of care in... | 25,113,520 | [
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A randomized controlled trial of an internet-based therapist-assisted indicated preventive intervention for prolonged grief disorder. | This trial assessed the feasibility, acceptability, tolerability, and efficacy of an Internet-based therapist-assisted cognitive-behavioral indicated prevention intervention for prolonged grief disorder (PGD) called Healthy Experiences After Loss (HEAL). Eighty-four bereaved individuals at risk for PGD were randomized ... | 25,113,524 | [
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Quality of life among people living with hypertension in a rural Vietnam community. | To respond to growing prevalence of hypertension in Vietnam, it is critical to have an in-depth understanding about quality of life (QOL) among people living with hypertension and related factors. This study aimed to measure QOL among hypertensive people in a rural community in Vietnam, and its association with socio-d... | 25,113,528 | [
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A semi-empirical approach to analyze the activities of cylindrical radioactive samples using gamma energies from 185 to 1764 keV. | This work suggests a method for determining the activities of cylindrical radioactive samples. The self-attenuation factor was applied for providing the self-absorption correction of gamma rays in the sample material. The experimental measurement of a (238)U reference sample and the calculation using the MCNP5 code all... | 25,113,537 | [
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Single-cell transcriptome in the identification of disease biomarkers: opportunities and challenges. | Single cell transcriptome defined as the entire RNA or polyadenylated products of RNA polymerase II on a cell can describe the gene regulation networks responsible for physiological functions, behaviours, and phenotypes in response to signals and microenvironmental changes. Single cell transcriptome/sequencing has the ... | 25,113,546 | [
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Impact of xylan on synergistic effects of xylanases and cellulases in enzymatic hydrolysis of lignocelluloses. | Supplementation of xylanase (XYL) has been found to synergistically improve the performance of cellulases (CEL) in the hydrolysis of lignocelluloses. However, the effect of xylan on the synergistic effects of XYL and CEL is still unclear. In this work, the effect of xylan on the synergy between CEL and XYL was investig... | 25,113,551 | [
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What can genes tell us about the relationship between education and health? | We use genome wide data from respondents of the Health and Retirement Study (HRS) to evaluate the possibility that common genetic influences are associated with education and three health outcomes: depression, self-rated health, and body mass index. We use a total of 1.7 million single nucleotide polymorphisms obtained... | 25,113,566 | [
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Adding insult to injury: The development of psychosocial stress in Ontario wind turbine communities. | Though historically dismissed as not-in-my-backyard (NIMBY) attitudes, reports of psychosocial stress linked to wind energy developments have emerged in Ontario, Canada. While the debate and rhetoric intensify concerning whether wind turbines 'actually' cause 'health' effects, less sincere attention has been given to t... | 25,113,568 | [
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A stair-climbing test for measuring mechanical efficiency of ambulation in adults with chronic stroke. | Mechanical efficiency can assess motor performance in individuals with physical disabilities. The purpose was to determine the utility of predicting it from heart rate (HR) during a self-paced stair-climbing test in adults with chronic hemiparesis after stroke and to determine the minimal detectable change of net mecha... | 25,113,573 | [
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An algorithm for score aggregation over causal biological networks based on random walk sampling. | We recently published in BMC Systems Biology an approach for calculating the perturbation amplitudes of causal network models by integrating gene differential expression data. This approach relies on the process of score aggregation, which combines the perturbations at the level of the individual network nodes into a g... | 25,113,603 | [
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Developmental profiles of GFAP-positive astrocytes in sheep cerebellum. | Astroglial account for the largest glial population in the brain and play a variety of vital functions in the development of the central nervous system (CNS). An immunohistochemical study was performed in 19 ovine foetuses ranging from 2 to 5 months of gestation, one newborn lamb and three adult sheep. Using the anit-g... | 25,113,608 | [
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Acoustic reflectors are visible in the right heart during radiofrequency ablation of varicose veins. | Cerebrovascular events have been noted after foam sclerotherapy for varicose veins. One hypothesis is migration of microemboli to the brain through a cardiac septal defect. The aim of this study was to identify whether acoustic reflectors are found in the right side of the heart during radiofrequency ablation of varico... | 25,113,612 | [
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Systematic review and meta-analysis on the efficacy of selective laser trabeculoplasty in open-angle glaucoma. | Selective laser trabeculoplasty (SLT) is a relatively new type of laser used in treating open-angle glaucoma (OAG) and is reported to be equally efficacious to a first-line medication and argon laser trabeculoplasty (ALT). We summarize available evidence for considering SLT as an alternative treatment in OAG through sy... | 25,113,610 | [
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The gene expression profile of cumulus cells reveals altered pathways in patients with endometriosis. | The objective of this experimental study was to compare the global gene expression profile of CC of mature oocytes in 18 patients with severe endometriosis and CC in 18 control patients affected by a severe male factor. For each group, the CC were pooled, RNA was extracted and a microarray performed. For validating the... | 25,113,618 | [
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A semi-probabilistic modelling approach for the estimation of dietary exposure to phthalates in the Belgian adult population. | In this study, a semi-probabilistic modelling approach was applied for the estimation of the long-term human dietary exposure to phthalates--one of world's most used families of plasticisers. Four phthalate compounds were considered: diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate (BBP) and ... | 25,113,625 | [
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Experimental investigation of the 2D ion beam profile generated by an ESI octopole-QMS system. | In this paper, we have employed an ion imaging approach to investigate the behavior of ions exiting from a quadrupole mass spectrometer (QMS) system that employs a radio frequency octopole ion guide before the QMS. An in-vacuum active pixel detector (Timepix) is employed at the exit of the QMS to image the ion patterns... | 25,113,629 | [
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Prostaglandin D2-supplemented "functional eicosanoid testing and typing" assay with peripheral blood leukocytes as a new tool in the diagnosis of systemic mast cell activation disease: an explorative diagnostic study. | Systemic mast cell activation disease (MCAD) is characterized by an enhanced release of mast cell-derived mediators, including eicosanoids, which induce a broad spectrum of clinical symptoms. Accordingly, the diagnostic algorithm of MCAD presupposes the proof of increased mast cell mediator release, but only a few medi... | 25,113,638 | [
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A simple and sensitive fluorescence based biosensor for the determination of uric acid using H2O2-sensitive quantum dots/dual enzymes. | A novel optical detection system consisting of combination of uricase/HRP-CdS quantum dots (QDs) for the determination of uric acid in urine sample is described. The QDs was used as an indicator to reveal fluorescence property of the system resulting from enzymatic reaction of uricase and HRP (horseradish peroxidase), ... | 25,113,659 | [
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Examining the link between adolescent brain development and risk taking from a social-developmental perspective (reprinted). | The adolescent age period is often characterized as a health paradox because it is a time of extensive increases in physical and mental capabilities, yet overall mortality/morbidity rates increase significantly from childhood to adolescence, often due to preventable causes such as risk taking. Asynchrony in development... | 25,113,660 | [
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Bone substitute first or screws first? A biomechanical comparison of two operative techniques for tibial-head depression fractures. | The aim of this study was to investigate a drillable and injectable bone substitute (calcium phosphate cement) and the operative technique enabled by the drillable option in a new biomechanical fracture model for tibial depression fractures in synthetic bones. Lateral depression fractures of the tibial plateau (AO 41-B... | 25,113,667 | [
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A taxonomic revision of South African Sharphydrus, with the description of two new species (Coleoptera: Dytiscidae: Bidessini). | Sharphydrus Omer-Cooper, 1958 is one of two endemic bidessine genera currently recognised from South Africa. Here Sharphydrus brincki sp. nov. and Sharphydrus kamiesbergensis sp. nov. are described from the Cederberg and Gydopas areas of the Western Cape, and the high Kamiesberg of the Northern Cape respectively, doubl... | 25,113,675 | [
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Cambarus (C.) hatfieldi, a new species of crayfish (Decapoda:Cambaridae) from the Tug Fork River Basin of Kentucky, Virginia and West Virginia, USA. | Cambarus (Cambarus) hatfieldi is a stream-dwelling crayfish that appears to be endemic to the Tug Fork River system of West Virginia, Virginia, and Kentucky. Within this region, it is prevalent in all major tributaries in the basin as well as the Tug Fork River's mainstem. The new species is morphologically most simila... | 25,113,694 | [
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An update of the blow flies (Diptera: Calliphoridae) of the Galápagos Islands, and first record of Chrysomya rufifacies (Macquart) from mainland Ecuador. | Seven species of Calliphoridae are reported from the Galápagos Islands, Ecuador: Lucilia pionia (Walker), L. setosa (James), L. deceptor (Curran), L. eximia (Wiedemann), Cochliomyia macellaria (Fabricius), Chrysomya albiceps (Wiedemann), and Chrysomya megacephala (Fabricius). Lucilia eximia is newly recorded from the i... | 25,113,695 | [
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Two new species of Aaptos (Demospongiae, Hadromerida) from Brazil (western Atlantic). | Twenty-one species of Aaptos Gray, 1867 are known world-wide, of which only three were reported from Brazil. Two new species of this genus are here described from the Brazilian coast (Potiguar Basin, Northeastern Brazil): A. hajdui sp. nov. and A. potiguarensis sp. nov. Both possess only one category of strongyloxeas a... | 25,113,704 | [
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Structure and photoluminescence studies of CeO2·CuAlO2 mixed metal oxide fabricated by co-precipitation method. | A novel mixed metal oxide, CeO2·CuAlO2 was fabricated by co-precipitation method in aqueous medium. CeO2·CuAlO2 was characterized by XRD, SEM, EDS, TEM, FTIR and PL spectra. The optical properties of the nanoparticles were studied by photoluminescence (PL) spectra. PL spectra at different excitations were recorded. The... | 25,113,734 | [
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A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation. | Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disorder resulting from germline mutations in the NF2 gene. Bilateral vestibular schwannomas, tumors on cranial nerve VIII, are pathognomonic for NF2 disease. Furthermore, schwannomas also commonly develop in other cranial nerves, dorsal root ganglia and p... | 25,113,746 | [
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Radical irradiation of extracranial oligometastases. | Advances in radiotherapy planning and delivery have been used to treat patients with limited metastatic disease. With these techniques, high rates of treated metastasis control and low toxicity have been reported. Some patients have long disease-free intervals after radiotherapy similar to those seen after surgical res... | 25,113,765 | [
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Long non-coding RNAs in cancer: implications for personalized therapy. | Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, we briefly intro... | 25,113,790 | [
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7T T₂*-weighted magnetic resonance imaging reveals cortical phase differences between early- and late-onset Alzheimer's disease. | The aim of this study is to explore regional iron-related differences in the cerebral cortex, indicative of Alzheimer's disease pathology, between early- and late-onset Alzheimer's disease (EOAD, LOAD, respectively) patients using 7T magnetic resonance phase images. High-resolution T2(∗)-weighted scans were acquired in... | 25,113,794 | [
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Different regions of bovine deep digital flexor tendon exhibit distinct elastic, but not viscous, mechanical properties under both compression and shear loading. | Tendons in different locations function in unique, and at times complex, in vivo loading environments. Specifically, some tendons are subjected to compression, shear and/or torsion in addition to tensile loading, which play an important role in regulating tendon properties. To date, there have been few studies evaluati... | 25,113,805 | [
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Molecular revision of the genus Wallaceina. | This work is focused on the molecular revision of the genus Wallaceina established in the very twilight of the classical morphotype-based approach to classification of the Trypanosomatidae. The genus was erected due to the presence of a unique variant of endomastigotes. In molecular phylogenetic studies four described ... | 25,113,831 | [
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Vessel caliber--a potential MRI biomarker of tumour response in clinical trials. | Our understanding of the importance of blood vessels and angiogenesis in cancer has increased considerably over the past decades, and the assessment of tumour vessel calibre and structure has become increasingly important for in vivo monitoring of therapeutic response. The preferred method for in vivo imaging of most s... | 25,113,840 | [
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Task specificity of attention training: the case of probability cuing. | Statistical regularities in our environment enhance perception and modulate the allocation of spatial attention. Surprisingly little is known about how learning-induced changes in spatial attention transfer across tasks. In this study, we investigated whether a spatial attentional bias learned in one task transfers to ... | 25,113,853 | [
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Control of the single-molecule magnet behavior of lanthanide-diarylethene photochromic assemblies by irradiation with light. | Lanthanide-based extended coordination frameworks showing photocontrolled single-molecule magnet (SMM) behavior were prepared by combining highly anisotropic Dy(III) and Ho(III) ions with the carboxylato-functionalized photochromic molecule 1,2-bis(5-carboxyl-2-methyl-3-thienyl)perfluorocyclopentene (H2 dae), which act... | 25,113,868 | [
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Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors. | A series of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acid derivatives (8a-f, 9a-m) were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro. Structure-activity relationship analyses have also been presented. Most of the target compounds exhibited potency levels in the nanomolar rang... | 25,113,879 | [
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Shadows from the past: the situated meaning of being suicidal among depressed older people living in the community. | Most depressed older people in a suicidal state have mixed feelings, where the wish to live and the wish to die wage a battle. To explore and describe depressed older people's experiences of being suicidal and their search for meaning. Data were collected from 29 participants resident in the Rogaland and Vestfold distr... | 25,113,890 | [
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Patient and physician views on the quality of care in inflammatory bowel disease: results from SOLUTION-1, a prospective IG-IBD study. | Remarkable differences in quality of care (QoC) might be observed in different countries, affecting quality of life of inflammatory bowel disease (IBD) patients. The aim of this study was to assess patient and physician perceptions of the QoC in Italy. A multicentre observational study on the quality of care in IBD (SO... | 25,113,898 | [
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Patchwork structure-function analysis of the Sendai virus matrix protein. | Paramyxoviruses contain a bi-lipidic envelope decorated by two transmembrane glycoproteins and carpeted on the inner surface with a layer of matrix proteins (M), thought to bridge the glycoproteins with the viral nucleocapsids. To characterize M structure-function features, a set of M domains were mutated or deleted. T... | 25,113,904 | [
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Chronic Δ⁹-tetrahydrocannabinol administration may not attenuate simian immunodeficiency virus disease progression in female rhesus macaques. | Persons living with HIV/AIDS (PLWHA) frequently use cannabinoids, either recreationally by smoking marijuana or therapeutically (delta-9-tetrahydrocannabinol; Δ(9)-THC dronabinol). Previously, we demonstrated that chronic Δ(9)-THC administration decreases early mortality in male simian immunodeficiency virus (SIV)-infe... | 25,113,915 | [
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Thrombotic thrombocytopenic purpura presenting with pathologic fracture: a case report. | Thrombotic thrombocytopenic purpura is an acute syndrome with abnormalities in multiple organ systems, which becomes manifest with microangiopathic hemolytic anemia and thrombocytopenia. The hereditary or acquired deficiency of ADAMTS-13 activity leads to an excess of high molecular weight von Willebrand factor multime... | 25,113,918 | [
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Biogenetic explanations and emotional reactions to people with schizophrenia and major depressive disorder. | Using population-based data, the relationship between biogenetic causal beliefs and emotional reactions to persons with schizophrenia or depression was examined. Biogenetic attributions elicited either negative emotions alone or pro-social and negative emotions at the same time. Biogenetic attributions seem not helpful... | 25,113,926 | [
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Static and rotational intensity modulated techniques for head-neck cancer radiotherapy: a planning comparison. | To compare helical Tomotherapy (HT), two volumetric-modulated arc techniques and conventional fixed-field intensity modulated techniques (S-IMRT) for head-neck (HN) cancers. Eighteen HN patients were considered. Four treatment plans were generated for each patient: HT, S-IMRT optimised with Eclipse treatment planning s... | 25,113,943 | [
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Relevance of subcortical visual pathways disruption to visual symptoms in dementia with Lewy bodies. | Visual hallucinations represent a core diagnostic criterion for dementia with Lewy bodies (DLB). We hypothesized that thalamic regions, which are critically involved in the modulation of visual transmission, may be differentially disrupted in DLB as compared to Alzheimer's Disease (AD) and that these deficits could rel... | 25,113,955 | [
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"Someone like us": delivering maternal mental health through peers in two South Asian contexts. | Peer-led psychosocial interventions are one solution to address the great paucity of skilled mental health human resources in South Asia. The aim of this study was to explore peer-delivered care for maternal depression in two diverse contexts in South Asia. The study was carried out in the urban setting of Goa, India a... | 25,113,958 | [
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Pathological mechanisms underlying aneurysmal subarachnoid haemorrhage and vasospasm. | Aneurysmal subarachnoid haemorrhage is a cerebrovascular disease associated with an overall mortality as high as 50%. Delayed ischaemic neurologic deficits are a major contributor to this statistic, as well as the significant morbidity associated with the disease. Studies examining the pathophysiologic events causing t... | 25,113,969 | [
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Differential diagnosis of three common Ixodes spp. ticks infesting songbirds of Western Europe: Ixodes arboricola, I. frontalis and I. ricinus. | The three most common Ixodes spp. ticks found on songbirds in Western Europe are Ixodes frontalis, I. arboricola and I. ricinus. As the latter species is a generalist, it shares several avian hosts with the two strictly ornithophilic species. Infestations of the three species can overlap in time and space, implying tha... | 25,113,983 | [
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Voltage control of Ca²⁺ permeation through N-type calcium (Ca(V)2.2) channels. | Voltage-gated calcium (Ca(V)) channels deliver Ca(2+) to trigger cellular functions ranging from cardiac muscle contraction to neurotransmitter release. The mechanism by which these channels select for Ca(2+) over other cations is thought to involve multiple Ca(2+)-binding sites within the pore. Although the Ca(2+) aff... | 25,114,024 | [
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0.06089953,
-0.1295216,
0.07579251,
0.2283041,
0.1864148,
0.07776726,
... |
Positive psychological states and health behaviors in acute coronary syndrome patients: A qualitative study. | Positive psychological states are linked to superior cardiac outcomes, possibly mediated through increased participation in health behaviors. Trained study staff conducted in-depth semi-structured interviews in the hospital and 3 months later for 34 patients diagnosed with an acute coronary syndrome. These interviews f... | 25,114,026 | [
-0.1975409,
0.2607248,
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0.06118824,
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0.0638276,
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0.006614842,
-0.003580312,
-0.06565557... |
Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis. | Research into Ginkgo biloba has been ongoing for many years, while the benefit and adverse effects of Ginkgo biloba extract EGb761 for cognitive impairment and dementia has been discussed controversially. To discuss new evidence on the clinical and adverse effects of standardized Ginkgo biloba extract EGb761 for cognit... | 25,114,079 | [
0.07538885,
0.3127573,
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0.1343289,
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0.6689325,
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0.3775751,
-0.4618198,
0.7441571,
0.1990316,
-0.35... |
The interaction of APOE genotype by age in amnestic mild cognitive impairment: a voxel-based morphometric study. | The apolipoprotein E (APOE) gene has been confirmed as the major genetic risk factor for the conversion of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). The present study was to assess whether there was a specific interaction of APOE by the aging process on brain morphology in aMCI. The analysi... | 25,114,090 | [
-0.02958253,
0.4086744,
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0.1026923,
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0.1706058,
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0.3555665,
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0.307162,
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0.1908006,
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0.2076894,
-0.08856016... |
The interleukin-1β/CXCL1/2/neutrophil axis mediates host protection against group B streptococcal infection. | Previous studies have indicated that group B streptococcus (GBS), a frequent human pathogen, potently induces the release of interleukin-1β (IL-1β), an important mediator of inflammatory responses. Since little is known about the role of this cytokine in GBS disease, we analyzed the outcome of infection in IL-1β-defici... | 25,114,117 | [
0.06330352,
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-0.4231765,
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0.1938566,
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-0.07102458,
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0.1672197,
0.286072,
0.3211762,
-0.054... |
Role of pathogen-derived cell wall carbohydrates and prostaglandin E2 in immune response and suppression of fish immunity by the oomycete Saprolegnia parasitica. | Saprolegnia parasitica is a freshwater oomycete that is capable of infecting several species of fin fish. Saprolegniosis, the disease caused by this microbe, has a substantial impact on Atlantic salmon aquaculture. No sustainable treatment against saprolegniosis is available, and little is known regarding the host resp... | 25,114,122 | [
-0.2360269,
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0.09778065,
0.1387634,
0.1924061,
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0.1417777,
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0.2006181,
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0.1578452,
0.113982,
0.4422633,
0.4498477,
0.2849373,
-0.4519718,
0.0... |
Chloroquine has a cytotoxic effect on Acanthamoeba encystation through modulation of autophagy. | Encystation of Acanthamoeba castellanii is associated with resistance to chemotherapeutic agents. Blocking the encystation process could potentiate the efficacy of chemotherapeutic agents and biocides. During encystation, autophagy is highly stimulated and required for proper encystation of Acanthamoeba. In this study,... | 25,114,131 | [
-0.3045507,
0.2346366,
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0.02668241,
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0.3099723,
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0.1224253,
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0.2851959,
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J.H. Pons on 'Sympathetic insanity': With an introduction by GE Berrios. | The ancient concept of 'sympathy' originally referred to a putative affinity or force that linked all natural objects together. This notion was later used to explain the manner in which human beings related and felt for each other. A large literature exists on both the physical and psychological definitions of sympathy... | 25,114,150 | [
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0.03893638,
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HMBPP-deficient Listeria mutant immunization alters pulmonary/systemic responses, effector functions, and memory polarization of Vγ2Vδ2 T cells. | Whereas infection or immunization of humans/primates with microbes coproducing HMBPP/IPP can remarkably activate Vγ2Vδ2 T cells, in vivo studies have not been done to dissect HMBPP- and IPP-driven expansion, pulmonary trafficking, effector functions, and memory polarization of Vγ2Vδ2 T cells. We define these phosphoant... | 25,114,162 | [
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0.1608527,
0.2710662,
-0.010689... |
Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. | Coronins are involved in the regulation of actin dynamics in a multifaceted way, participating in cell migration and vesicular trafficking. Apicomplexan parasites, which exhibit an actin-dependent gliding motility that is essential for traversal through tissues, as well as invasion of and egress from host cells, expres... | 25,114,175 | [
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0.04112036,
0.1166796,
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0.3449056,
0.03950... |
Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. | SUMOylation is an essential ubiquitin-like modification involved in important biological processes in eukaryotic cells. Identification of small ubiquitin-related modifier (SUMO)-conjugated residues in proteins is critical for understanding the role of SUMOylation but remains experimentally challenging. We have set up a... | 25,114,211 | [
-0.05324133,
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0.112245,
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0.0648225,
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0.0203911,
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0.1773755,
0.3158959,
0.008205994... |
Rare earth elements activate endocytosis in plant cells. | It has long been observed that rare earth elements (REEs) regulate multiple facets of plant growth and development. However, the underlying mechanisms remain largely unclear. Here, using electron microscopic autoradiography, we show the life cycle of a light REE (lanthanum) and a heavy REE (terbium) in horseradish leaf... | 25,114,214 | [
0.1469301,
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0.008534755,
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0.2495542,
0.08631492,
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0.4150037,
0.8524509,
-0.0822573... |
Small RNA combination therapy for lung cancer. | MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering miRNA mimics and siRNAs to lung adenocarcinoma cells in vitro and to tumors in a genetically e... | 25,114,235 | [
-0.2226779,
0.07046576,
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0.01102201,
-0.06492107,
-0.0003456084,
0.1528219,
-0.056... |
Marine ammonia-oxidizing archaeal isolates display obligate mixotrophy and wide ecotypic variation. | Ammonia-oxidizing archaea (AOA) are now implicated in exerting significant control over the form and availability of reactive nitrogen species in marine environments. Detailed studies of specific metabolic traits and physicochemical factors controlling their activities and distribution have not been well constrained in... | 25,114,236 | [
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0.1824541,
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0.002849866,
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0.2494215,
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0.03461644,
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-0.7102903,
0.3257968,
0.1584491,
0.123757,
-0.02764352,
0.2212497,
-0.05336107,... |
Collective credit allocation in science. | Collaboration among researchers is an essential component of the modern scientific enterprise, playing a particularly important role in multidisciplinary research. However, we continue to wrestle with allocating credit to the coauthors of publications with multiple authors, because the relative contribution of each aut... | 25,114,238 | [
-0.06794165,
0.3307446,
0.05588743,
0.1001872,
0.2325409,
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0.3229562,
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0.1896381,
0.0246941,
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0.2883728,
0.1235668,
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0.15629,
-0.168847,
0.2051302,
-0.07959159,
... |
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. | The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytansine, which is part of an ADC that is approved by the US Food and Drug Ad... | 25,114,240 | [
0.01617463,
-0.005297785,
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0.2046415,
0.1397095,
0.01038587,
0.3334547,
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0.2431894,
0.2418001,
0.282129,
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0.09206132,
-0.068194,
0.2594697,
0.4080362,
-0.155871,
-... |
Fractal branching organizations of Ediacaran rangeomorph fronds reveal a lost Proterozoic body plan. | The branching morphology of Ediacaran rangeomorph fronds has no exact counterpart in other complex macroorganisms. As such, these fossils pose major questions as to growth patterns, functional morphology, modes of feeding, and adaptive optimality. Here, using parametric Lindenmayer systems, a formal model of rangeomorp... | 25,114,255 | [
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0.02503303,
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0.133672,
0.06521251,
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0.1839755,
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0.2449092,
0.138401,
-0.0521791... |
Patterned progression of bacterial populations in the premature infant gut. | In the weeks after birth, the gut acquires a nascent microbiome, and starts its transition to bacterial population equilibrium. This early-in-life microbial population quite likely influences later-in-life host biology. However, we know little about the governance of community development: does the gut serve as a passi... | 25,114,261 | [
0.08051422,
0.1380717,
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0.3137032,
0.1689985,
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0.20181,
0.4240174,
0.09915664,
-... |
"Pictures don't lie, seeing is believing": exploring attitudes to the introduction of pictorial warnings on cigarette packs in Ghana. | To compare perceptions of text and pictorial warning labels on cigarette packs among Ghanaian smokers and nonsmokers and to explore their views on the introduction of pictorial warnings in Ghana. Qualitative study involving 12 focus group discussions with 50 smokers and 35 nonsmokers aged 15 years and older in Kumasi, ... | 25,114,265 | [
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0.09279503,
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0.2671991,
0.4763195,
0.01919841,
... |
Police exposure to infectious agents: an audit of protective policies. | As first responders, police officers may be exposed to infectious agents such as hepatitis viruses and human immunodeficiency virus. Their risk of infection by these viruses can be reduced with training, monitoring and, with some viruses, vaccination. To examine infection prevention policies and practices among police ... | 25,114,270 | [
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0.2496502,
0.03074443,
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0.208065,
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0.4495855,
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0.05404168,
0.239119,
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0.09243761,
-0.07614473,
-0.2276333,
-0.1013243,
... |
Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. | Perilipin 1 is a lipid droplet coat protein predominantly expressed in adipocytes, where it inhibits basal and facilitates stimulated lipolysis. Loss-of-function mutations in the PLIN1 gene were recently reported in patients with a novel subtype of familial partial lipodystrophy, designated as FPLD4. We now report the ... | 25,114,292 | [
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0.2375229,
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0.3806779,
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0.2019695,
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-0.2381837,
-0.1439033,
0.1686301,
0.2764401,
0.03678604,
0.5028766,
0.08840194,
... |
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