title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Modulation of autoimmune rheumatic diseases by oestrogen and progesterone. | Sexual dimorphism is evident in the risk and expression of several human autoimmune diseases. Differences in disease manifestations observed between sexes are likely to involve immunomodulation by sex steroids, nonhormonal factors encoded by genes on the X and Y chromosomes, and immunological phenomena unique to pregna... | 25,155,581 | [
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Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea. | Intermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. Th... | 25,155,586 | [
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Differential subcutaneous adipose tissue gene expression patterns in a randomized clinical trial of efavirenz or lopinavir-ritonavir in antiretroviral-naive patients. | Gene expression studies of subcutaneous adipose tissue may help to better understand the mechanisms behind body fat changes in HIV-infected patients who initiate antiretroviral therapy (ART). Here, we evaluated early changes in adipose tissue gene expression and their relationship to fat changes in ART-naive HIV-infect... | 25,155,608 | [
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Risk factors for acute kidney injury (AKI) in infants with melamine-associated urolithiasis and follow-up: a multi-center retrospective analysis. | Abstract An epidemic of urinary tract stones was noted among infants in China, 2008. This event was believed to be associated with consumption melamine-contaminated powdered formula. The patients with symptoms and clinical manifests had already been analyzed in our previous studies. In this study, our aim is to investi... | 25,155,621 | [
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Highly sensitive fluorescent probe for clenbuterol hydrochloride detection based on its catalytic oxidation of eosine Y by NaIO4. | A highly sensitive fluorescent probe for clenbuterol hydrochloride (CLB) detection has been first designed based on its catalytic effect on NaIO4 oxidating eosine Y (R). And this environment-friendly, simple, rapid, selective and sensitive fluorescent probe has been utilized to detect CLB in the practical samples with ... | 25,155,629 | [
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Captive marsupial nutrition. | Marsupials comprise an interesting group of mammals, which are increasingly being kept as pets. Few actual feeding trials have been published, although many anecdotal diets have years of usage with good success. Marsupials have dental and digestive tract adaptations that allow them to use specific niches in their envir... | 25,155,664 | [
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Prescription diets for rabbits. | Dietary management can be used with drug therapy for the successful treatment of many diseases. Therapeutic nutrition is well-recognized in dogs and cats and is beginning to increase among other pet species, including rabbits. The nutritional component of some rabbit diseases (eg, urolithiasis) is not completely unders... | 25,155,667 | [
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The relationship between pelvis-trunk coordination and low back pain in individuals with transfemoral amputations. | Low back pain (LBP) is common in individuals with transfemoral amputation and may result from altered gait mechanics associated with prosthetic use. Inter-segmental coordination, assessed through continuous relative phase (CRP), has been used to identify specific patterns as risk factors. The purpose of this study was ... | 25,155,692 | [
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Trunk sway during walking among older adults: norms and correlation with gait velocity. | The aim of this study was to establish quantitative norms for trunk sway during walking for older male and female ambulatory adults at different age groups (65-70, 71-75, 76-80, ≥81). We also assessed the relationship between dynamic trunk sway and gait velocity in older individuals with clinically normal or abnormal g... | 25,155,693 | [
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Semi-automatic segmentation for 3D motion analysis of the tongue with dynamic MRI. | Dynamic MRI has been widely used to track the motion of the tongue and measure its internal deformation during speech and swallowing. Accurate segmentation of the tongue is a prerequisite step to define the target boundary and constrain the tracking to tissue points within the tongue. Segmentation of 2D slices or 3D vo... | 25,155,697 | [
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Crescent flap for fingertip reconstruction. | A volar advancement flap based on V-Y concept for fingertip reconstruction is described. The crescent flap utilises curved incision to preserve fingertip contour and distal digital crease. Satisfactory outcome was achieved in two patients who underwent fingertip reconstruction using this technique. Its advantages are t... | 25,155,705 | [
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Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration. | Objective. Lumbar spinal stenosis is one of the most commonly diagnosed spinal disorders in older adults. Although the pathophysiology of the clinical syndrome is not well understood, a narrow central canal or intervertebral foramen is an essential or defining feature. The aim of the present study was to estimate the m... | 25,155,712 | [
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Renal replacement therapy in neonates. | The incidence of acute kidney injury (AKI) has steadily increased in the last decade in neonates and infants. Despite the extensive proposed pharmacologic approaches to treat or prevent AKI, renal replacement therapy is the only available therapeutic approach to manage the consequences of significant AKI and maintain e... | 25,155,724 | [
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Hematuria in the newborn. | Microscopic and gross hematuria, while rare in healthy newborns, is more common in premature infants, particularly those cared for in the neonatal intensive care unit. Hematuria may be transient, but may require evaluation, investigation, and intervention in a timely manner. This article discusses the causes, workup, a... | 25,155,729 | [
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Nephrotic and nephritic syndrome in the newborn. | Glomerular disorders in infancy can include nephrotic and nephritic syndromes. Congenital nephrotic syndrome (CNS) is most commonly caused by single gene mutations in kidney proteins, but may also be due to congenital infections or passive transfer of maternal antibodies that target kidney proteins. Prenatal findings o... | 25,155,730 | [
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Diagnosis and management of urinary tract infection and vesicoureteral reflux in the neonate. | Urinary tract infection (UTI) is the most common bacterial infection in febrile newborns, particularly those born prematurely and with a low birth weight. Vesicoureteral reflux (VUR) predisposes to UTI and renal scarring. Half of neonates with UTI may have only low-grade fever or no fever. Jaundice in the absence of an... | 25,155,732 | [
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Disorders of the bladder and cloacal anomaly. | The incidence of congenital urachal, bladder, and cloacal anomalies is low. Urachal remnants are the result of failure or delay in obliteration of the allantois. Exstrophy of the bladder or cloaca can be diagnosed on prenatal ultrasonography and represent a deviation from the normal embryologic sequence. Persistent clo... | 25,155,736 | [
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Neuropathic bladder in the neonate. | The management of infants born with myelomeningocele depends on understanding how their bladder stores and empties urine. Storage at low pressure with effective emptying periodically throughout the day is the goal. Intervention is designed to impact on one or both of these processes so that infants can remain infection... | 25,155,738 | [
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Spatial and temporal organization of signaling pathways. | The development and maintenance of the many different cell types in metazoan organisms requires robust and diverse intercellular communication mechanisms. Relatively few such signaling pathways have been identified, leading to the question of how such a broad diversity of output is generated from relatively simple sign... | 25,155,749 | [
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The somatic genomic landscape of chromophobe renal cell carcinoma. | We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney ca... | 25,155,756 | [
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Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. | We have previously reported that colonic pericryptal microvascular blood flow is augmented in the premalignant colonic epithelium, highlighting the increased metabolic demand of the proliferative epithelium as a marker of field carcinogenesis. However, its molecular basis is unexplored. In this study, we assessed the e... | 25,155,760 | [
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Association between the ABO blood group and risk of common cancers. | To investigate the association between five common cancers in western China population and ABO blood group. Using the data from West China Hospital, we retrospectively reviewed 5012 patients with five common cancers. Blood groups were obtained from medical records. The control group was represented by 1979 health check... | 25,155,765 | [
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The complexity of newborn screening follow-up in phenylketonuria. | In the United States, and most developed nations, the newborn screening (NBS) panel covers many primary disorders of metabolism, including phenylketonuria (PKU). When an elevated phenylalanine level is identified, the infant is evaluated for PKU and should also be tested for tetrahydrobiopterin (BH4) deficiency. A neon... | 25,155,776 | [
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[Pulsed-dose rate brachytherapy in cervical cancers: why, how?]. | The end of the production of 192 iridium wires terminates low dose rate brachytherapy and requires to move towards pulsed-dose rate or high-dose rate brachytherapy. In the case of gynecological cancers, technical alternatives exist, and many teams have already taken the step of pulsed-dose rate for scientific reasons. ... | 25,155,782 | [
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Linking algal growth inhibition to chemical activity: baseline toxicity required 1% of saturation. | Recently, high-quality data were published on the algal growth inhibition caused by 50 non-polar narcotic compounds, of which 39 were liquid compounds with defined water solubility. In the present study, the toxicity data for these liquids were applied to challenge the chemical activity range for baseline toxicity. Fir... | 25,155,827 | [
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ART and uterine pathology: how relevant is the maternal side for implantation? | Assisted reproduction technology (ART) has become a standard treatment for infertile couples. Increased success rates obtained over the years have resulted primarily from improved embryo quality, but implantation rates still remain lower than expected. The uterus, an important player in implantation, has been frequentl... | 25,155,826 | [
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Management of a major atlanto-axial instability secondary to a lytic lesion of C2. | Management of C1-C2 instability is very challenging, especially when tumoral lesions are involved. We present the case of a 65-year-old male, with a recently discovered small cell lung carcinoma, presenting progressive tetraparesis due to a secondary lesion involving the body of C2 with complete collapse of its anterio... | 25,155,833 | [
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AMPD1 functional variants associated with autism in Han Chinese population. | Autism is a childhood neurodevelopmental disorder with high heterogeneity. Following our genome-wide associated loci with autism, we performed sequencing analysis of the coding regions, UTR and flanking splice junctions of AMPD1 in 830 Chinese autism individuals as well as 514 unrelated normal controls. Fourteen novel ... | 25,155,876 | [
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Characterization of long-term in vitro culture-related alterations of human tonsil-derived mesenchymal stem cells: role for CCN1 in replicative senescence-associated increase in osteogenic differentiation. | Although mesenchymal stem cells (MSC) isolated from bone marrow and adipose tissues are known to be subjected to in vitro culture-related alterations in their stem cell properties, such data have not been reported in human tonsil-derived MSC (T-MSC). Here, we investigated the culture-related changes of phenotypes, the ... | 25,155,898 | [
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[Freehand SPECT for navigation and sentinel node detection in breast cancer]. | The sentinel lymph node (SLN) is a standard for the surgical treatment of axillary localized breast cancer N0. It is based on a double isotopic and color detection. With a gamma detecting probe connected to an infrared camera, Déclipse SPECT system (Surgiceye(®)) is able to detect and locate any radioactive source in 3... | 25,155,906 | [
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0.4296283,
0.1431617,
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0.548... |
Ultrasound-based tracking strategy for endoluminal devices in cardiovascular surgery. | Magnetic endovascular navigation of wireless or soft-tethered endoluminal devices was recently proposed in the literature. This approach allows for innovative therapeutic procedures, but developing a real-time tracking strategy, compatible with magnetic dragging, is a challenging problem and is not yet solved. Two-dime... | 25,155,910 | [
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Multiple squamous cell carcinomas following introduction of nilotinib. | Nilotinib is a second generation tyrosine kinase inhibitor, used in the treatment of chronic myelogenous leukaemia (CML). We assessed a 72-year-old woman who was treated with nilotinib for CML. During the year following commencement of nilotinib, the patient developed eight squamous cell carcinomas (SCCs) on her legs. ... | 25,155,911 | [
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Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. | Type II bacterial topoisomerases are well validated targets for antimicrobial chemotherapy. Novel bacterial type II topoisomerase inhibitors (NBTIs) of these targets are of interest for the development of new antibacterial agents that are not impacted by target-mediated cross-resistance with fluoroquinolones. We now di... | 25,155,913 | [
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Postmortem urinary catecholamine levels with regard to the cause of death. | Previous studies suggested that serum catecholamines are useful for investigating stress responses in the death process. The present study analyzed postmortem urinary adrenaline (Ad), noradrenaline (Nad) and dopamine (DA) in serial forensic autopsy cases (n=199: 154 males and 45 females; age >9years; survival time &... | 25,155,919 | [
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Cyclosporine A regulates pro-inflammatory cytokine production in ulcerative colitis. | Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel diseases (IBD), which are defined as relapsing inflammations of the gastrointestinal tract. Cyclosporine A (CsA) is a potential rescue treatment to avoid colectomy in severe steroid-refractory UC patients. The molecular mecha... | 25,155,925 | [
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Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes. | Familial loading for alcohol dependence (AD) and variation in genes reported to be associated with AD or BMI were tested in a longitudinal study. Growth curve analyses of BMI data collected at approximately yearly intervals and obesity status (BMI > 30) were examined. High-risk males were found to have higher BMI th... | 25,155,933 | [
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Genetic epidemiology of pharmacogenetic variations in CYP2C9, CYP4F2 and VKORC1 genes associated with warfarin dosage in the Indian population. | Warfarin, a widely used anticoagulant, exhibits large interindividual variability in dose requirements. CYP2C9 and VKORC1 polymorphisms in various ethnic groups have been extensively studied as genetic markers associated with variable drug response. However, allele frequencies of these variants have not been assessed i... | 25,155,935 | [
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Enteral granulocyte-colony stimulating factor and erythropoietin early in life improves feeding tolerance in preterm infants: a randomized controlled trial. | To evaluate the efficacy and safety of enteral recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human erythropoietin (rhEPO) in preventing feeding intolerance. An interventional randomized control trial was conducted in 90 preterm infants born at ≤33 weeks gestational age. The neonates ... | 25,155,966 | [
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Structure-guided design of thiazolidine derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors. | The pantothenate biosynthetic pathway is essential for the persistent growth and virulence of Mycobacterium tuberculosis (Mtb) and one of the enzymes in the pathway, pantothenate synthetase (PS, EC: 6.3.2.1), encoded by the panC gene, has become an appropriate target for new therapeutics to treat tuberculosis. Herein, ... | 25,155,986 | [
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Instrumental variable methods to assess quality of care the marginal effects of process-of-care on blood pressure change and treatment costs. | Hypertension is poorly controlled. Team-based care and changes in the process of care have been proposed to address these quality problems. However, assessing care processes is difficult because they are often confounded even in randomized behavioral studies by unmeasured confounders based on discretion of health care ... | 25,155,998 | [
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Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos. | One quarter of eukaryotic genes encode membrane proteins. These include nearly 1,000 transporters that translocate nutrients, signaling molecules, and xenobiotics across membranes. While it is well appreciated that membrane transport is critical for development, the specific roles of many transporters have remained cry... | 25,156,004 | [
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Usefulness of quantifying leukocytes in first-voided urine to predict positivity for Chlamydia trachomatis in asymptomatic men at high risk for chlamydial infection. | Chlamydia trachomatis causes acute non-gonococcal urethritis, but some infected men are asymptomatic. We examined leukocytes in uncentrifuged first-voided urine (FVU) from asymptomatic men at high risk for chlamydial infection by automated urine particle analyzers to assess whether the quantification of urinary leukocy... | 25,156,010 | [
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0.068... |
The effects of Andrographis paniculata (Burm.f.) Nees extract and diterpenoids on the CYP450 isoforms' activities, a review of possible herb-drug interaction risks. | Andrographis paniculata (Burm.f.) Nees is a popular medicinal plant and its components are used in various traditional product preparations. However, its herb-drug interactions risks remain unclear. This review specifically discusses the various published studies carried out to evaluate the effects of Andrographis pani... | 25,156,015 | [
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[Is there overuse of neuroimaging procedures in patients with chronic migraine? An study in a Health Area in Asturias, Spain]. | There is a general perception of neuroimaging procedures overuse, mainly of CT scan, in patients with headache in Spain. To analyze the use of neuroimaging techniques, mainly CT scan as it is of free access in our region, in routine clinical practice in patients with chronic migraine (CM). We reviewed the medical recor... | 25,156,024 | [
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Breech-strike on mulesed, clipped and unmulesed Merino ewes and hoggets in south-eastern Australia. | Compare breech-strike on Merino ewes and hoggets that were mulesed, had breech and tail clips applied ('clipped') or left unmulesed and treated strategically with long-acting insecticide. A cohort study on two farms in southern Victoria. Three treatment groups were established at lamb marking in 2008 and 2009 on each f... | 25,156,054 | [
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Production and citation of cochrane systematic reviews: a bibliometrics analysis. | To evaluate the production and utilization of Cochrane systematic reviews(CSRs) and to analyze its influential factors, so as to improve the capacity of translating CSRs into practice. All CSRs and protocols were retrieved from the Cochrane Library ISSUE 2, 2011 and citation data were retrieved from SCI database. Citat... | 25,156,081 | [
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Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment. | The population genomics of Pseudomonas aeruginosa was analysed by genome sequencing of representative strains of the 15 most frequent clonal complexes in the P. aeruginosa population and of the five most common clones from the environment of which so far no isolate from a human infection has been detected. Gene annotat... | 25,156,090 | [
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A technique to ensure the reproducibility of a cast post and core. | The post-and-core pattern duplication technique is a simple, cost-effective, and accurate method of ensuring the reproducibility of a cast post and core. An acrylic resin pattern is fabricated for an endodontically treated tooth. The post portion of the pattern is duplicated with a polyvinyl siloxane impression materia... | 25,156,094 | [
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Kinesiographic study of masticatory movements in denture wearers with normal and resorbed denture-bearing areas. | An unfavorable denture-bearing area could compromise denture retention and stability, limit mastication, and possibly alter masticatory motion. The purpose of this study was to evaluate the masticatory movements of denture wearers with normal and resorbed denture-bearing areas. Completely edentulous participants who re... | 25,156,095 | [
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Bridle procedure combined with a subtalar implant: a case series and review of the literature. | The bridle procedure is a tritendon anastomosis between the tibialis posterior, peroneus longus, and tibialis anterior, utilized in the treatment of drop foot. Concerned about the potential for acquired flatfoot deformity following the bridle procedure, the authors hypothesized that placing a sinus tarsi implant would ... | 25,156,098 | [
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A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination. | Seven HMG-box proteins of Aspergillus nidulans have been identified in the genomic databases. Three of these have the characteristics of non-specific DNA-binding proteins. One of these, AN1267 (HmbB), comprises one canonical HMG-box in its C-terminus and upstream of the canonical box two structurally related boxes, to ... | 25,156,107 | [
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Molecular mechanism of action of 2-ferrocenyl-1,1-diphenylbut-1-ene on HL-60 leukemia cells. | The aim of this work was to investigate the mechanism of action of 2-ferrocenyl-1,1-diphenylbut-1-ene (1) on HL-60 human leukemia cells. While inactive against noncancerous cells, 1 provoked a concentration-dependent decrease in viable tumor cells, primarily via apoptosis, as evidenced by analysis of cell morphology, a... | 25,156,124 | [
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Capability of new bone formation with a mixture of hydroxyapatite and beta-tricalcium phosphate granules. | The aim of this experimental study was to test a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) granules inserted in cranial defects in rabbits, by the evaluation of the hard tissues volume, new bone formation, and residual graft after 4 and 8 weeks. Two defects of 8 mm diameter were created at... | 25,156,136 | [
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... |
Corneal abnormalities early in the course of Fuchs' endothelial dystrophy. | Corneas with advanced Fuchs' endothelial dystrophy that require endothelial keratoplasty manifest anterior corneal structural and cellular abnormalities that have been associated with visual deficits before and after endothelial keratoplasty. In this study, we determined the onset of these abnormalities in the course o... | 25,156,138 | [
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Simulation in the Internet age: the place of web-based simulation in nursing education. An integrative review. | The objective of this article was to review the literature on utilisation and place of Web-based simulation within nursing education. Web-based simulation combines electronic multimedia options with a central video or virtual world to produce interactive learning activities mediated by the learner. An integrative revie... | 25,156,144 | [
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Substrate binding activates the designed triple mutant of the colicin E7 metallonuclease. | The nuclease domain of colicin E7 (NColE7) cleaves DNA nonspecifically. The active center is a Zn(2+)-containing HNH motif at the C-terminus. The N-terminal loop is essential for the catalytic activity providing opportunity for allosteric modulation of the enzyme. To identify the key residues responsible for the struct... | 25,156,149 | [
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Multifaceted interplay between lipophilicity, protein interaction and luminescence parameters of non-intercalative ruthenium(II) polypyridyl complexes controlling cellular imaging and cytotoxic properties. | Here, we examine the photophysical properties of five ruthenium(II) complexes comprising two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and functionalized bipyridine (R₁bpy-R₂, where R₁= H or CH3, R₂= H, CH₃, COO⁻,4-[3-(2-nitro-1H-imidazol-1-yl)propyl] or 1,3-dicyclohexyl-1-carbonyl-urea) towards development of lum... | 25,156,150 | [
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Home blood pressure and cardiovascular outcomes in patients during antihypertensive therapy: primary results of HONEST, a large-scale prospective, real-world observational study. | This study aimed to investigate the relationship between on-treatment morning home blood pressure (HBP) and incidence of cardiovascular events using data from the Home Blood Pressure Measurement With Olmesartan Naive Patients to Establish Standard Target Blood Pressure (HONEST) study, a prospective observational study ... | 25,156,169 | [
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New agar microspheres for the separation and purification of natural products. | A new type of agar chromatography media has been prepared with a yield over 80% using a water-in-oil emulsion technique. These microspheres have regular spherical shapes and particle diameters in the range 40-165 μm (average ∼90 μm). Cross-linking of the resulting agar microspheres with epichlorohydrin and 1,4-butanedi... | 25,156,195 | [
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Validation of the LupusPRO in Chinese patients from Hong Kong with systemic lupus erythematosus. | LupusPRO is a disease-targeted, patient-reported outcome (PRO) measure that was developed and validated for assessment of quality of life in US patients with systemic lupus erythematosus (SLE). We present results of adapting the LupusPRO into Chinese and testing its psychometric properties in Chinese patients with SLE.... | 25,156,199 | [
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Small RNA deep sequencing identifies novel and salt-stress-regulated microRNAs from roots of Medicago sativa and Medicago truncatula. | Small 21- to 24-nucleotide (nt) ribonucleic acids (RNAs), notably the microRNA (miRNA), are emerging as a posttranscriptional regulation mechanism. Salt stress is one of the primary abiotic stresses that cause the crop losses worldwide. In saline lands, root growth and function of plant are determined by the action of ... | 25,156,209 | [
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Gender differences and patterns of cardiovascular risk factors in Type 1 and Type 2 diabetes: a population-based analysis from a Scottish region. | To explore the gender differences, along with the relationships between BMI, glycaemic control, cardiovascular risk factors and the prevalence of diabetes complications, in a representative population-based group of people with Type 1 and Type 2 diabetes. Data were obtained from general practices in Ayrshire and Arran,... | 25,156,218 | [
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Variation in malariometric and red cell indices in children in the Mount Cameroon area following enhanced malaria control measures: evidence from a repeated cross-sectional study. | Following enhanced malaria control measures, such as nationwide free distribution of insecticide-treated bed nets (ITN) by the government of Cameroon, its impact on malariometric and red cell indices in children ≤14 years in Muea, in the Mount Cameroon area was evaluated. Two cross-sectional studies were conducted duri... | 25,156,237 | [
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Efficiency of irrigation water application in sugarcane cultivation in Pakistan. | Diminishing irrigation water supplies are threatening the sustainability of irrigated agriculture in Pakistan. Within the context of dwindling water resources and low agricultural water productivity, it is imperative to improve efficiency in agricultural production and to make efficient use of available water resources... | 25,156,252 | [
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Quantitative risk assessment of haemolytic and uremic syndrome linked to O157:H7 and non-O157:H7 Shiga-toxin producing Escherichia coli strains in raw milk soft cheeses. | Shiga-toxin producing Escherichia coli (STEC) strains may cause human infections ranging from simple diarrhea to Haemolytic Uremic Syndrome (HUS). The five main pathogenic serotypes of STEC (MPS-STEC) identified thus far in Europe are O157:H7, O26:H11, O103:H2, O111:H8, and O145:H28. Because STEC strains can survive or... | 25,156,259 | [
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Process development for recovery of vanadium and nickel from an industrial solid waste by a leaching-solvent extraction technique. | A process for recovering V(V) and Ni(II) from an industrial solid waste using sulfuric acid leaching, solvent extraction, precipitation and crystallization has been developed. The leaching parameters investigated were time, temperature and H2SO4 concentration. To quantify the linear and interaction coefficients a 2(3) ... | 25,156,262 | [
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Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. | The transmembrane isoforms of carbonic anhydrase (hCA IX and XII) have been shown to be linked to carcinogenesis and their inhibition to arrest primary tumor and metastases growth. In this paper, we present a new class of C-glycosides incorporating the methoxyaryl moiety, that was designed to selectively target and inh... | 25,156,300 | [
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Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties. | Multitarget compounds are increasingly being pursued for the effective treatment of complex diseases. Herein, we describe the design and synthesis of a novel class of shogaol-huprine hybrids, purported to hit several key targets involved in Alzheimer's disease. The hybrids have been tested in vitro for their inhibitory... | 25,156,301 | [
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How are previous physical activity and self-efficacy related to future physical activity and self-efficacy? | Self-efficacy (SE) has been found to be a robust predictor of success in achieving physical activity (PA) goals. While much of the current research has focused on SE as a trait, SE as a state has received less attention. Using day-to-day measurements obtained over 84 days, we examined the relationship between state SE ... | 25,156,312 | [
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The therapeutic alliance in a naturalistic psychiatric setting: temporal relations with depressive symptom change. | Numerous studies have reported associations between the therapeutic alliance and depressive symptom improvement in outpatient samples. However, little is known regarding the temporal relationship between the alliance and symptom change among relatively severely depressed patients receiving treatment in naturalistic, ps... | 25,156,322 | [
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The GAVI Alliance and the 'Gates approach' to health system strengthening. | Lauded for getting specific health issues onto national and international agendas and for their potential to improve value for money and outcomes, public-private global health initiatives (GHIs) have come to dominate global health governance. Yet, they have also been criticised for their negative impact on country heal... | 25,156,323 | [
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Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. | Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort to d... | 25,156,329 | [
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Detecting reliable cognitive change in individual patients with the MATRICS Consensus Cognitive Battery. | Clinicians often need to evaluate the treatment response of an individual person and to know that observed change is true improvement or worsening beyond usual week-to-week changes. This paper gives clinicians tools to evaluate individual changes on the MATRICS Consensus Cognitive Battery (MCCB). We compare three diffe... | 25,156,338 | [
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High-performance liquid chromatography LTQ-Orbitrap mass spectrometry method for tomatidine and non-target metabolites quantification in organic and normal tomatoes. | Tomatoes, members of the Solanaceae plant family, produce biologically active secondary metabolites, including glycoalkaloids and aglycons, which may have both adverse and beneficial biological effects. A new liquid chromatography method that utilized LTQ-Orbitrap MS was developed for the analysis of tomatidine, the ma... | 25,156,359 | [
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Screening nephroprotective compounds from cortex Moutan by mesangial cell extraction and UPLC. | A method for screening nephroprotective compounds in cortex Moutan, a common traditional Chinese medicine (TCM) in treating diabetic nephropathy with renal mesangial cell extraction and ultra performance liquid chromatography technique was described in this paper. We hypothesize that the compounds which bind to cell me... | 25,156,360 | [
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Axl receptor blockade protects from invasive pulmonary aspergillosis in mice. | Aspergillus fumigatus is a sporulating fungus found ubiquitously in the environment, which is quickly contained in the immunocompetent host but can cause lethal invasive aspergillosis in the immunocompromised host. We have recently demonstrated that Axl (one member of the Tyro3, Axl, Mertk receptor family) is a key reg... | 25,156,363 | [
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Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. | Psoriasis is a chronic autoimmune disease affecting the skin and characterized by aberrant keratinocyte proliferation and function. Immune cells infiltrate the skin and release proinflammatory cytokines that play important roles in psoriasis. The Th17 network, including IL-23 and IL-22, has recently emerged as a critic... | 25,156,366 | [
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Basophils promote innate lymphoid cell responses in inflamed skin. | Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group 2 innate lymphoid cells (ILC2s) in inflamed skin lesions. Although murine studies have demonstrated that cutaneous basophil and ILC2 responses are dependent on thymic stromal lymp... | 25,156,365 | [
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The Research Domain Criteria (RDoC): an analysis of methodological and conceptual challenges. | In a bold effort to address the longstanding shortcomings of the Diagnostic and Statistical Manual (DSM) framework for the classification and diagnosis of psychopathology, the National Institute of Mental Health recently launched a research program - the Research Domain Criteria (RDoC) - in the hopes of developing an a... | 25,156,396 | [
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Augmenting one-session treatment of children's specific phobias with attention training to positive stimuli. | This study examined the efficacy of combining two promising approaches to treating children's specific phobias, namely attention training and one 3-h session of exposure therapy ('one-session treatment', OST). Attention training towards positive stimuli (ATP) and OST (ATP+OST) was expected to have more positive effects... | 25,156,398 | [
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Clinical and imaging follow-up after surgical or endovascular treatment in patients with unruptured carotid-ophthalmic aneurysm. | Carotido-ophthalmic aneurysms are complex and their treatment is challenging. Few data are available on patient follow-up after endovascular or surgical treatment. To evaluate outcome of patients with unruptured carotido-ophthalmic aneurysm after endovascular or surgical treatment. This series included 52 consecutive p... | 25,156,408 | [
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Part II: predictors of depression after stroke and impact of depression on stroke outcome: an updated systematic review of observational studies. | We previously published a systematic review in 2005 on factors associated with the development of depression in people with stroke. To update and expand that review to include published data on the impact of depression on stroke outcome. We included all published observational studies (to May 31, 2013) with prospective... | 25,156,411 | [
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High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population. | Recent studies have shown associations of hypothyroidism with arterial blood pressure, atherosclerosis, and inflammation. Based on these pathways, there might also be an association between hypothyroidism and retinal arteriolar narrowing (RAN), a marker of microvascular damage from hypertension, atherosclerosis, and in... | 25,156,414 | [
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... |
Interferons: Success in anti-viral immunotherapy. | The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of the first lines of host defense against invading pathogens. These proteins are classified into three groups, Type I, II and III IFNs, based on the structure of their receptors on the cell surface. Due to their ability to mod... | 25,156,421 | [
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0.1230374,
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Effect of dried California Mission figs on mineral status and food replacement. | Figs are a rich source of several different minerals and fibres. We studied the effect of the consumption of dried California Mission figs on mineral and nutrient levels, as well as the effect of the addition of figs to a self-selected habitual diet on dietary patterns. A crossover randomized controlled trial study des... | 25,156,424 | [
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Modulation of tibialis anterior muscle activity changes with upright stance width. | When individuals stand with their feet apart, activation of tibialis anterior (TA) muscle seems to slightly exceed rest levels. In narrow stances, conversely, the stabilization of body lateral sways may impose marked, active demand on ankle inversors/eversors. In this study we investigate how much the modulation in TA ... | 25,156,446 | [
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Preclinical trial of a novel surface architecture for improved primary fixation of cementless orthopaedic implants. | A new surface architecture for cementless orthopaedic implants (OsteoAnchor), which incorporates a multitude of tiny anchor features for enhancing primary fixation, was tested in an ovine hemi-arthroplasty pilot study. Test animals were implanted with a hip stem component incorporating the OsteoAnchor surface architect... | 25,156,456 | [
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0.4080867,
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A big-microsite framework for soil carbon modeling. | Soil carbon cycling processes potentially play a large role in biotic feedbacks to climate change, but little agreement exists at present on what the core of numerical soil C cycling models should look like. In contrast, most canopy models of photosynthesis and leaf gas exchange share a common 'Farquhaur-model' core st... | 25,156,470 | [
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0.09734593,
0.4593402,
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Reduction of Leishmania donovani infectivity in whole blood using riboflavin and ultraviolet light. | Leishmaniasis is a vector-borne disease caused by the protozoan parasite Leishmania sp. that is transmitted by sandflies. Travelers to endemic areas, and US military personnel stationed in the Middle East, are at risk for contracting the disease. Whole blood (WB) units were spiked with human monocytes infected with L. ... | 25,156,473 | [
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... |
Development of β-cyclodextrin-based sustained release microparticles for oral insulin delivery. | Polymeric microparticles have been previously demonstrated to deliver various therapeutic agents efficiently to targeted regions by protecting the drug from harsh gastric milieu of the gastrointestinal tract. In this study, we investigated the hypoglycemic effect of β-cyclodextrin polymeric insulin microparticles in di... | 25,156,483 | [
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Associations between bicycling and carotid arterial stiffness in adolescents: The European Youth Hearts Study. | The aim of the study was to investigate the associations between bicycling and carotid arterial stiffness, independent of objectively measured moderate-and-vigorous physical activity. This cross-sectional study included 375 adolescents (age 15.7 ± 0.4 years) from the Danish site of the European Youth Heart Study. Total... | 25,156,494 | [
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0.1578253,
0.2795864,
0.0184092,
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0.068... |
Psychological impact of first-trimester prevention for preeclampsia on anxiety. | This study aims to examine whether a first-trimester strategy of secondary prevention for preeclampsia increases anxiety in pregnant women. The anxiety levels of a cohort of women screened for preeclampsia at first trimester were measured by the Spielberg State-Trait Anxiety Inventory (STAI-S) and compared between wome... | 25,156,501 | [
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0.4802089,
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... |
The effects of word-learning biases on children's concept of angle. | Despite evidence that young children are sensitive to differences in angle measure, older students frequently struggle to grasp this important mathematical concept. When making judgments about the size of angles, children often rely on erroneous dimensions such as the length of the angles' sides. The present study test... | 25,156,505 | [
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0.3289117,
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0... |
Effect of a family-centered, secondhand smoke intervention to reduce respiratory illness in indigenous infants in Australia and New Zealand: a randomized controlled trial. | Secondhand smoke (SHS) is a significant cause of acute respiratory illness (ARI) and 5 times more common in indigenous children. A single-blind randomized trial was undertaken to determine the efficacy of a family centered SHS intervention to reduce ARI in indigenous infants in Australia and New Zealand. Indigenous mot... | 25,156,527 | [
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0.143646,
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... |
Triggering through Toll-like receptor 2 limits chronically stimulated T-helper type 1 cells from undergoing exhaustion. | Chronic infections result in T-cell exhaustion, a state of functional unresponsiveness. To control the infection, it is important to salvage the exhausted T cells. In this study, we delivered signals through Toll-like receptor 2 (TLR-2) to reinvigorate functionality in chronically activated T-helper type 1 (Th1) cells.... | 25,156,558 | [
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Pre-meal tomato (Lycopersicon esculentum) intake can have anti-obesity effects in young women? | The effect of pre-meal tomato intake in the anthropometric indices and blood levels of triglycerides, cholesterol, glucose, and uric acid of a young women population (n = 35, 19.6 ± 1.3 years) was evaluated. During 4 weeks, daily, participants ingested a raw ripe tomato (∼90 g) before lunch. Their anthropometric and bi... | 25,156,566 | [
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0.4993404,
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Relationship between clinical improvement and functional gains with clozapine in schizophrenia. | Impairment in psychosocial functioning is a key feature in schizophrenia, but few studies have examined the relationship between improvements in symptoms and functioning. We examined the relationship between change in symptoms and change in functioning in a group of patients with treatment-resistant schizophrenia after... | 25,156,578 | [
0.302461,
0.2230477,
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0.1113976,
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0.2396223,
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-0.251... |
Oxidative cleavage of benzylic C-N bonds under metal-free conditions. | An interesting procedure for the oxidative cleavage of benzylic C-N bonds has been developed. Using TBAI as the catalyst and H2O2 as the oxidant, various benzylamines were transformed into their corresponding aromatic aldehydes in moderate to good yields. Notably, this is the first example of an oxidative cleavage of b... | 25,156,588 | [
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0... |
Brain structural substrates of cognitive procedural learning in alcoholic patients early in abstinence. | Procedural learning allows for the acquisition of new behavioral skills. Previous studies have shown that chronic alcoholism is characterized by impaired cognitive procedural learning and brain abnormalities affecting regions that are involved in the automation of new cognitive procedures in healthy individuals. The go... | 25,156,613 | [
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Chronic methylphenidate treatment during early life is associated with greater ethanol intake in socially isolated rats. | Methylphenidate (MPH) is a stimulant prescribed to treat attention-deficit/ hyperactivity disorder. Its primary mechanism of action is in the dopamine system, alterations of which are associated with vulnerability to alcohol abuse. There are concerns that juvenile MPH treatment may influence adult drinking behavior. Th... | 25,156,616 | [
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0.2973006,
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0.1196471,
0.1617684,
0.007173415,
0.1519677,
-0.... |
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