title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Ozone induces stomatal narrowing in European and Siebold's beeches: a comparison between two experiments of free-air ozone exposure. | Stomata tend to narrow under ozone (O(3)) impact, leading to limitation of stomatal O(3) influx. Here, we review stomatal response under recently conducted free-air O(3) exposure experiments on two species of the same tree genus: Fagus sylvatica at Kranzberg Forest (Germany) and F. crenata at Sapporo Experimental Fores... | 25,156,633 | [
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The microRNA-146a/b attenuates acute small-for-size liver graft injury in rats. | A critical role of the Toll-like receptor (TLR)-4 and its downstream mediators in the pathogenesis of small-for-size liver graft injury has been documented. Recently, the microRNA-146 (miR-146) was identified as a potent negative regulator of the TLR4 signalling pathway. In this study, the role of miR-146a and miR-146b... | 25,156,638 | [
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The 1,470-nm bare-fiber diode laser ablation of the great saphenous vein and small saphenous vein at 1-year follow-up using 8-12 W and a mean linear endovenous energy density of 72 J/cm. | To demonstrate 1-year outcomes after low-energy endovenous laser ablation (EVLA) of incompetent saphenous veins with linear endovenous energy density (LEED) of 80 J/cm or lower with the use of a 1,470-nm diode laser. Incompetent saphenous veins in 236 patients (355 limbs; Clinical/Etiology/Anatomy/Pathophysiology class... | 25,156,646 | [
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Update on Clostridium difficile infections. | Clostridium difficile infections (CDI) occur primarily in hospitalized patients with risk factors such as concomitant or recent use of antibiotics. CDI related additional costs are important for the global population and health-care facilities. CDI epidemiology has changed since 2003: they became more frequent boosted ... | 25,156,678 | [
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First report of image integration of cine-angiography with 3D electro-anatomical mapping of the right ventricle in postoperative tetralogy of Fallot. | Ventricular tachycardia and, more rarely, sudden cardiac death are potential complications affecting the long-term outcome after Tetralogy of Fallot (ToF) repair. Intraventricular septal scar, fibro-fatty substitution around infundibular resection and patchy myocardial fibrosis may provide anatomical substrates of abno... | 25,156,690 | [
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Recycling of electric arc furnace dust through dissolution in deep eutectic ionic liquids and electrowinning. | The dust waste formed during steelmaking in electric arc furnace (EAF) is rich in ferrous and nonferrous metals. Recycling of this dust as a raw material in iron or steel-making is hazardous and therefore it is mostly dumped. This paper demonstrates recycling of EAF dust through selective dissolution of metal oxides in... | 25,156,719 | [
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Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1. | Apical membrane antigen 1 (AMA1) is a leading malarial vaccine candidate; however, its polymorphic nature may limit its success in the field. This study aimed to circumvent AMA1 diversity by dampening the antibody response to the highly polymorphic loop Id, previously identified as a major target of strain-specific, in... | 25,156,737 | [
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Involvement of stress-related genes polB and PA14_46880 in biofilm formation of Pseudomonas aeruginosa. | Chronic infections of Pseudomonas aeruginosa are generally established through production of biofilm. During biofilm formation, production of an extracellular matrix and establishment of a distinct bacterial phenotype make these infections difficult to eradicate. However, biofilm studies have been hampered by the fact ... | 25,156,741 | [
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Sleep and breathing. | The sleep state is associated with significant changes in respiratory physiology, including ventilatory responses to hypoxia and hypercapnia, upper airway and intercostal muscle tone, and tidal volume and minute ventilation. These changes are further magnified in certain disease states, such as chronic obstructive pulm... | 25,156,761 | [
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Consumer acceptability and sensory profile of cooked broccoli with mustard seeds added to improve chemoprotective properties. | Broccoli, a rich source of glucosinolates, is a commonly consumed vegetable of the Brassica family. Hydrolysis products of glucosinolates, isothiocyanates, have been associated with health benefits and contribute to the flavor of Brassica. However, boiling broccoli causes the myrosinase enzyme needed for hydrolysis to ... | 25,156,799 | [
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Intervening to enhance cortisol regulation among children at risk for neglect: Results of a randomized clinical trial. | The hypothalamus-pituitary-adrenal axis is particularly sensitive to conditions of maltreatment. In particular, neglected children have shown a flatter slope with lower wake-up values relative to nonneglected children. An intervention, the Attachment and Biobehavioral Catch-Up (ABC), was developed to enhance biological... | 25,156,798 | [
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Changes in dermal papilla structures due to aging in the facial cheek region. | In the past, it has been possible to measure the dermal papilla structures which are undulations between the epidermis and dermis by noninvasive method. However, almost all of previous studies were not intended to measure facial skin but another site of body. Here, we investigated age-dependent alterations for dermal p... | 25,156,803 | [
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Apparent rate constant mapping using hyperpolarized [1-(13)C]pyruvate. | Hyperpolarization of [1-13C]pyruvate in solution allows real-time measurement of uptake and metabolism using MR spectroscopic methods. After injection and perfusion, pyruvate is taken up by the cells and enzymatically metabolized into downstream metabolites such as lactate, alanine, and bicarbonate. In this work, we pr... | 25,156,807 | [
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Utility of respiratory ward-based NIV in acidotic hypercapnic respiratory failure. | We sought to elicit predictors of in-hospital mortality for first and subsequent admissions with acidotic hypercapnic respiratory failure (AHRF) in a cohort of chronic obstructive pulmonary disease patients who have undergone ward-based non-invasive ventilation (NIV), and identify features associated with long-term sur... | 25,156,832 | [
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Monitoring of dabigatran anticoagulation and its reversal in vitro by thrombelastography. | Dabigatran etexilate, a pro-drug of a direct thrombin inhibitor, was approved a few years ago for non-valvular atrial fibrillation and deep venous thrombosis. Rapid monitoring of the dabigatran level is essential in trauma and bleeding patients but the traditional plasma-based assays may not sufficiently display the ef... | 25,156,858 | [
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Decreasing trends in hospitalizations during anti-TNF therapy are associated with time to anti-TNF therapy: Results from two referral centres. | Hospitalization is an important outcome measure and a major driver of costs in patients with inflammatory bowel disease. We analysed medical and surgical hospitalization rates and predictors of hospitalization before and during anti-TNF therapy. Data from 194 consecutive patients were analysed retrospectively (males, 4... | 25,156,871 | [
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Effects of inhaled bronchodilators on lung function and cycling performance in female athletes with and without exercise-induced bronchoconstriction. | Inhaled β2-agonists may cause differential effects on lung function and athletic performance in female compared to male athletes. The objective of this study was to compare the effects of inhaled β2-agonists on lung function and cycling performance between female athletes with and without exercise-induced bronchoconstr... | 25,156,879 | [
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Postural orthostatic tachycardia syndrome (POTS): association with Ehlers-Danlos syndrome and orthopaedic considerations. | Postural orthostatic tachycardia syndrome (POTS) is the most common of several types of dysautonomia, characterized by dysfunction of the autonomic nervous system manifesting with symptoms of orthostatic intolerance with or without associated orthostatic hypotension and excessive autonomic excitation. Given the numerou... | 25,156,902 | [
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Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. | Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than tra... | 25,156,908 | [
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Pelvic floor muscle training for bowel dysfunction following colorectal cancer surgery: A systematic review. | To identify, evaluate and synthesize the evidence examining the effectiveness of pelvic floor muscle training (PFMT) on bowel dysfunction in patients who have undergone colorectal cancer surgery. Eight electronic databases (MEDLINE 1950-2014; CINAHL 1982-2014; EMBASE 1980-2014; Scopus 1823-2014; PsycINFO 1806-2014; Web... | 25,156,929 | [
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The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. | The hepatic cytochrome 2D6 (CYP2D6) is a saturable enzyme responsible for metabolism of approximately 25% of known pharmaceuticals. CYP interactions can alter the efficacy of prescribed medications. Hydrocodone is largely dependent on CYP2D6 metabolism for analgesia, ondansetron is inactivated by CYP2D6, and oxycodone ... | 25,156,930 | [
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Quality and reporting of publications by Indonesian researchers: a literature survey. | To evaluate the quality of reporting of the risk of bias of the Indonesian medical research. Publications from PubMed and non-PubMed indexed Indonesian medical journals between January 2008 to December 2010 were assessed for risk of bias based on criterion combination from Hedges-criteria and the Oxford Center for Evid... | 25,156,942 | [
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Targeted next-generation sequencing in the diagnosis of neurodevelopmental disorders. | We developed a next-generation sequencing (NGS) based mutation screening strategy for neurodevelopmental diseases. Using this system, we screened 284 genes in 40 patients. Several novel mutations were discovered. Patient 1 had a novel mutation in ACTB. Her dysmorphic feature was mild for Baraitser-Winter syndrome. Pati... | 25,156,961 | [
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Changing reproductive effort within a semelparous reproductive episode. | • Life-history theory predicts a trade-off between current and future reproduction for iteroparous organisms-as individuals age, the expected value of future reproduction declines, and thus reproductive effort is expected to be higher in later clutches than in earlier. In contrast, models explaining the evolution of se... | 25,156,981 | [
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Spatially coordinated changes in intracellular rheology and extracellular force exertion during mesenchymal stem cell differentiation. | The mechanical properties within the cell are regulated by the organization of the actin cytoskeleton, which is linked to the extracellular environment through focal adhesion proteins that transmit force. Chemical and mechanical stimuli alter the organization of cytoskeletal actin, which results in changes in cell shap... | 25,156,989 | [
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Subdural hemorrhage and hypoxia in infants with congenital heart disease. | It has been suggested that there is a causal relationship between hypoxia and subdural hemorrhage (SDH) in infancy. The purpose of this study was to review the incidence of SDH in infants with congenital heart disease and explore the relationship between SDH and hypoxia. Review of data collected for a prospective longi... | 25,157,008 | [
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Fluoride use in caries prevention in the primary care setting. | Dental caries remains the most common chronic disease of childhood in the United States. Caries is a largely preventable condition, and fluoride has proven effectiveness in the prevention of caries. The goals of this clinical report are to clarify the use of available fluoride modalities for caries prevention in the pr... | 25,157,014 | [
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Distinct roles for mitogen-activated protein kinase signaling and CALMODULIN-BINDING TRANSCRIPTIONAL ACTIVATOR3 in regulating the peak time and amplitude of the plant general stress response. | To survive environmental challenges, plants have evolved tightly regulated response networks, including a rapid and transient general stress response (GSR), followed by well-studied stress-specific responses. The mechanisms underpinning the GSR have remained elusive, but a functional cis-element, the rapid stress respo... | 25,157,030 | [
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Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome. | Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. We compared the light-chain use of anti-GM1 IgM antibodies in serum f... | 25,157,033 | [
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Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes. | Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that is highly resistant to lysozyme, a ubiquitous enzyme of the innate immune system that degrades cell wall peptidoglycan. Two peptidoglycan-modifying enzymes, PgdA and OatA, confer lysozyme resistance on L. monocytogenes; however, these enz... | 25,157,076 | [
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Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications. | Holins form pores in the cytoplasmic membranes of bacteria for the primary purpose of releasing endolysins that hydrolyze the cell wall and induce cell death. Holins are encoded within bacteriophage genomes, where they promote cell lysis for virion release, and within bacterial genomes, where they serve a diversity of ... | 25,157,079 | [
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Drug-induced autoimmune hemolytic anemia in a 78-year-old African-American man with chronic lymphocytic leukemia. | 78-year-old African-American man. Chronic lymphocytic leukemia first diagnosed in 2003, with a subsequent relapse in 2006 and another in 2010. In late 2011, the patient was admitted to the hospital for cholelithiasis, at which time his treating physician incidentally discovered severe anemia. The anemia worsened as tim... | 25,157,090 | [
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Soil-transmitted helminths in pre-school-aged and school-aged children in an urban slum: a cross-sectional study of prevalence, distribution, and associated exposures. | Soil-transmitted helminths (STHs) are controlled by regular mass drug administration. Current practice targets school-age children (SAC) preferentially over pre-school age children (PSAC) and treats large areas as having uniform prevalence. We assessed infection prevalence in SAC and PSAC and spatial infection heteroge... | 25,157,123 | [
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RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. | Latent viral infection is a persistent cause of human disease. Although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. The prokaryotic immune system clustered regularl... | 25,157,128 | [
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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells. | To determine the role of glucagon action in diet-induced and genetic type 2 diabetes (T2D), we studied high-fat-diet-induced obese (DIO) and leptin receptor-defective (LepR(-/-)) rodents with and without glucagon receptors (GcgRs). DIO and LepR(-/-),GcgR(+/+) mice both developed hyperinsulinemia, increased liver sterol... | 25,157,166 | [
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Directed evolution of a far-red fluorescent rhodopsin. | Microbial rhodopsins are a diverse group of photoactive transmembrane proteins found in all three domains of life. A member of this protein family, Archaerhodopsin-3 (Arch) of halobacterium Halorubrum sodomense, was recently shown to function as a fluorescent indicator of membrane potential when expressed in mammalian ... | 25,157,169 | [
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Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. | Precise spatiotemporal control of mRNA translation machinery is essential to the development of highly complex systems like the neocortex. However, spatiotemporal regulation of translation machinery in the developing neocortex remains poorly understood. Here, we show that an RNA-binding protein, Hu antigen R (HuR), reg... | 25,157,170 | [
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Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1. | Neurodegenerative disorders are strongly linked to protein misfolding, and crucial to their explication is a detailed understanding of the underlying structural rearrangements and pathways that govern the formation of misfolded states. Here we use single-molecule optical tweezers to monitor misfolding reactions of the ... | 25,157,171 | [
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Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptor. | We predicted the structural basis for pleiotropic signaling of the C-C chemokine type 5 (CCR5) G protein-coupled receptor (GPCR) by predicting the binding of several ligands to the lower-energy conformations of the CCR5 receptor and 11 mutants. For each case, we predicted the ∼ 20 most stable conformations for the rece... | 25,157,173 | [
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Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization. | Biofilm-protected microbial infections in skin are a serious health risk that remains to be adequately addressed. The lack of progress in developing effective treatment strategies is largely due to the transport barriers posed by the stratum corneum of the skin and the biofilm. In this work, we report on the use of Ion... | 25,157,174 | [
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Sustaining observations of the unsteady ocean circulation. | Sustained observations of ocean properties reveal a global warming trend and rising sea levels. These changes have been documented by traditional ship-based measurements of ocean properties, whereas more recent Argo profiling floats and satellite records permit estimates of ocean changes on a near real-time basis. Thro... | 25,157,191 | [
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Specific profile of tau isoforms in argyrophylic grain disease. | Argyrophylic grain disease (AGD) is a neurodegenerative condition that has been classified among the sporadic tauopathies. Entities in this group present intracellular aggregates of hyperphosphorylated tau, giving rise to characteristic neuronal and glial inclusions. In different tauopathies, the proportion of several ... | 25,157,208 | [
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Age-related changes in motor cortical representation and interhemispheric interactions: a transcranial magnetic stimulation study. | To better understand the physiological mechanisms responsible for the differential motor cortex functioning in aging, we used transcranial magnetic stimulation to investigate interhemispheric interactions and cortical representation of hand muscles in the early phase of physiological aging, correlating these data with ... | 25,157,232 | [
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Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration. | Vascular smooth muscle cells (VSMCs) migration is a critical process during human uterine spiral artery (SpA) remodeling and a successful pregnancy. Extravillous trophoblast cells (EVT) interact with VSMC and enhance their migration, however, the mechanisms by which EVT remodel SpA remain to be fully elucidated. We hyp... | 25,157,233 | [
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Egypt's Red Sea coast: phylogenetic analysis of cultured microbial consortia in industrialized sites. | The Red Sea possesses a unique geography, and its shores are rich in mangrove, macro-algal and coral reef ecosystems. Various sources of pollution affect Red Sea biota, including microbial life. We assessed the effects of industrialization on microbes along the Egyptian Red Sea coast at eight coastal sites and two lake... | 25,157,243 | [
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Effects of mesenchymal stromal cell-derived extracellular vesicles on tumor growth. | Extracellular vesicles (EVs) are membrane vesicles, which are secreted by a variety of cells that have a relevant role in intercellular communication. EVs derived from various cell types exert different effects on target cells. Mesenchymal stromal cells (MSCs) are stem cells that are ubiquitously present in different t... | 25,157,253 | [
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Simulation-based mastery learning with deliberate practice improves clinical performance in spinal anesthesia. | Introduction. Properly performing a subarachnoid block (SAB) is a competency expected of anesthesiology residents. We aimed to determine if adding simulation-based deliberate practice to a base curriculum improved performance of a SAB. Methods. 21 anesthesia residents were enrolled. After baseline assessment of SAB on ... | 25,157,263 | [
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Melanoma: A new strategy to reduce morbidity and mortality. | Public awareness campaigns could address risk factors for melanoma to reinforce their sun protection message. The objective of this study is to prioritise risk factors associated with malignant melanoma (MM) to improve public awareness. A cross-sectional study with retrospective data analysis from 2004 to 2010. Wester... | 25,157,266 | [
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The effect of an electronic health record system on nursing staff time in a nursing home: a longitudinal cohort study. | Nursing homes are increasingly introducing electronic health record (EHR) systems into nursing practice; however, there is limited evidence about the effect of these systems on nursing staff time. To investigate the effect of introducing an EHR system on time spent on activities by nursing staff in a nursing home. An o... | 25,157,268 | [
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Follicular bronchiolitis in primary ciliary dyskinesia. | Ciliary dysfunction in primary ciliary dyskinesia (PCD) may be associated with bronchiolitis. Diffuse bronchiolitis has been reported in a subset of PCD patients who have Kartagener's syndrome in Japan. We report a case of follicular bronchiolitis (FB) in a case of PCD presenting with recurrent episodes of cough, dyspn... | 25,157,269 | [
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DAXAS and COPD Correlation with Cancer. | A new drug for chronic obstructive pulmonary disease has been recently added as a treatment for certain patients. However, new evidences indicate that there might be a connection with lung cancer. It is known that smoking is a major factor that induces chronic pulmonary disease and smoking is associated with lung cance... | 25,157,272 | [
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Health information, an area for competition in Swedish pharmacies. | To investigate the views and expectations of a selected group of customers regarding health information in Swedish pharmacies. A repeated cross sectional, questionnaire study carried out in 2004 and 2005. Customers buying calcium products answered questions on osteoporosis and general questions on health promotion and ... | 25,157,284 | [
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Number sense or working memory? The effect of two computer-based trainings on mathematical skills in elementary school. | Research on the improvement of elementary school mathematics has shown that computer-based training of number sense (e.g., processing magnitudes or locating numbers on the number line) can lead to substantial achievement gains in arithmetic skills. Recent studies, however, have highlighted that training domain-general ... | 25,157,301 | [
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Mitigating concerns and maximizing returns: social media strategies for injury prevention non-profits. | Injury prevention programs can use social media to disseminate information and recruit participants. Non-profit organizations have also used social media for fundraising and donor relationship management. Non-profit organizations (NPOs) with injury prevention missions often serve vulnerable populations. Social media pl... | 25,157,305 | [
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Relationship between bases of power and job stresses: role of mentoring. | Building upon the social exchange theory, this paper hypothesized the direct effect of bases of power on job stress with mentoring as moderator. Power bases and job stresses were conceptualized as 7- and 3- dimensional constructs, respectively. One hundred and ninety-five Malaysian managers and executives working in la... | 25,157,334 | [
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0.2559884,
0.126796... |
An evidence-based review of NX1207 and its potential in the treatment of benign prostatic hyperplasia. | In elderly men, benign prostatic hyperplasia is often associated with lower urinary tract symptoms, and its prevalence rises with age. Lower urinary tract symptoms can be very bothersome and lead to a decrease in health-related quality of life. Furthermore, benign prostatic hyperplasia is a progressive disease that can... | 25,157,337 | [
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Religious affiliation as a predictor of involuntary psychiatric admission: a brazilian 1-year follow-up study. | The aim of this study was to analyze factors associated with the legal status at psychiatric admission of individuals with psychosis or bipolar disorder in a Latin-American cultural setting. Prospective observational study was conducted in São Paulo, Brazil. We analyzed 169 individuals with bipolar or psychotic disorde... | 25,157,344 | [
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Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia. | Approximately 30% of schizophrenia patients do not respond adequately to the therapy. Previous MRI studies have suggested that drug treatment resistance is associated with brain morphological abnormalities, although region-of-interest analysis of MR studies from nonresponder and responder patients failed to demonstrate... | 25,157,354 | [
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Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. | Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne... | 25,157,359 | [
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Biological effects of Spirulina (Arthrospira) biopolymers and biomass in the development of nanostructured scaffolds. | Spirulina is produced from pure cultures of the photosynthetic prokaryotic cyanobacteria Arthrospira. For many years research centers throughout the world have studied its application in various scientific fields, especially in foods and medicine. The biomass produced from Spirulina cultivation contains a variety of bi... | 25,157,367 | [
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Intrapartum ultrasound assessment of fetal spine position. | We investigated the role of foetal spine position in the first and second labour stages to determine the probability of OPP detection at birth and the related obstetrical implications. We conducted an observational-longitudinal cohort study on uncomplicated cephalic single foetus pregnant women at term. We evaluated th... | 25,157,368 | [
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Progress in the identification of dengue virus entry/fusion inhibitors. | Dengue fever, a reemerging disease, is putting nearly 2.5 billion people at risk worldwide. The number of infections and the geographic extension of dengue fever infection have increased in the past decade. The disease is caused by the dengue virus, a flavivirus that uses mosquitos Aedes sp. as vectors. The disease has... | 25,157,370 | [
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A comparative analysis of swarm intelligence techniques for feature selection in cancer classification. | Feature selection in cancer classification is a central area of research in the field of bioinformatics and used to select the informative genes from thousands of genes of the microarray. The genes are ranked based on T-statistics, signal-to-noise ratio (SNR), and F-test values. The swarm intelligence (SI) technique fi... | 25,157,377 | [
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Dissecting the functional role of the N-terminal domain of the human small heat shock protein HSPB6. | HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecular chaperones that bind partially unfolded proteins and prevent them from aggregating. In vertebrate sHSPs the poorly structured N-terminal domain has been implicated in both chaperone activity and the formation of higher... | 25,157,403 | [
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Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood. | Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored Treg presence and funct... | 25,157,414 | [
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Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation. | During postnatal murine maturation, behavioral patterns emerge and become shaped by experience-dependent adaptations. During the same period, the morphology of dendritic spines, the morphological correlates of excitatory synapses, is known to change, and there is evidence of concurrent alterations of the synaptosomal p... | 25,157,418 | [
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Reduced representations capacity in visual working memory in trait anxiety. | Neural processes that support individual differences in trait anxiety and the amount of representations in visual-spatial working memory (WM) are currently unclear. We measured the contralateral delay activity (CDA) in a lateralized change detection task to explore this question. Different levels of memory load were va... | 25,157,423 | [
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Multiplexed programmable release of captured DNA. | Nucleic-acid hybridization is widely used for the specific capture of complementary sequences from complex samples. It is useful for both analytical methodologies, such as array hybridization (e.g. transcriptome analysis, genetic-variation analysis), and preparative strategies such as exome sequencing and sequence-spec... | 25,157,426 | [
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Reformulation of pizza crust in restaurants may increase whole-grain intake among children. | Whole-grain intake among children is well below recommendations. The purpose of the present study was to test the acceptability and liking of pizza made with whole-grain crust compared with refined-grain crust among children in restaurant and school settings. Plate waste data were collected via observation from child r... | 25,157,427 | [
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Extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in murine spleen. | The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the... | 25,157,451 | [
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Application of high-resolution MS in the quantification of a therapeutic monoclonal antibody in human plasma. | Monoclonal antibodies are the fastest growing class of protein therapeutics. Ligand-binding assays have been the technique of choice for the quantification of these large proteins; however, LC-MS and more recently LC-HRMS have been gaining momentum as robust alternatives for the bioanalysis of antibodies in biological ... | 25,157,484 | [
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Quantitation of human peptides and proteins via MS: review of analytically validated assays. | Since the development of monoclonal antibodies in the 1970s, antibody-based assays have been used for the quantitation of proteins and peptides and, today, they are the most widely used technology in routine laboratory medicine and bioanalysis. However, in the last couple of decades, liquid chromatography-mass spectrom... | 25,157,489 | [
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CLEARance wars: PolyQ strikes back. | Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance. | 25,157,508 | [
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An exploration of evolution, maturation, expression and function relationships in mir-23 ∼ 27 ∼ 24 cluster. | The study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23 ∼ 27 ∼ 24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically selected as an ex... | 25,157,521 | [
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Invasive amoebiasis: a review of Entamoeba infections highlighted with case reports. | Entamoeba histolytica infections of the gastrointestinal tract are common in the developing world but rare in North America. The authors present two cases: one involving an individual who had not travelled to an endemic area and another involving an individual who was born in Bulgaria. Both presented with severe abdomi... | 25,157,525 | [
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Novel diagnostic and therapeutic techniques for surveillance of dysplasia in patients with inflammatory bowel disease. | The risk for developing dysplasia and colorectal cancer in patients with longstanding inflammatory bowel disease (IBD) involving the colon is well documented. Random biopsies during white-light, standard-definition colonoscopy (33 to 50 biopsies) with or without dye spraying chromoendoscopy has been the recommended str... | 25,157,526 | [
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Marijuana use in hepatitis C infection does not affect liver biopsy histology or treatment outcomes. | Marijuana smoking is prevalent among hepatitis C virus-infected patients. The literature assessing the influence of marijuana on liver disease progression and hepatitis C virus antiviral treatment outcomes is conflicting. The authors evaluated hepatitis C virus RNA-positive patients followed at The Ottawa Hospital Vira... | 25,157,529 | [
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Functional magnetic resonance imaging as experienced by stroke survivors. | Functional magnetic resonance imaging (fMRI), a noninvasive technique that measures brain activation, has been increasingly used in the past decade, particularly among older adults. Use of fMRI in research with stroke survivors in recent years has substantially contributed to researchers' understanding of the pathophys... | 25,157,535 | [
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An in-line photonic biosensor for monitoring of glucose concentrations. | This paper presents two PDMS photonic biosensor designs that can be used for continuous monitoring of glucose concentrations. The first design, the internally immobilized sensor, consists of a reactor chamber, micro-lenses and self-alignment structures for fiber optics positioning. This sensor design allows optical det... | 25,157,552 | [
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A flexible and transparent graphene/ZnO nanorod hybrid structure fabricated by exfoliating a graphite substrate. | We demonstrate the fabrication of a graphene/ZnO nanorod (NR) hybrid structure by mechanical exfoliation of ZnO NRs grown on a graphite substrate. We confirmed the existence of graphene sheets on the hybrid structure by analyzing the Raman spectra and current-voltage (I-V) characteristics. The Raman spectra of the exfo... | 25,157,564 | [
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A comprehensive evaluation of fasting serum gastrin-17 as a predictor of diseased stomach in Chinese population. | Fasting serum gastrin-17 (FsG17) is considered as a noninvasive biomarker reflecting the structure and functional status of gastric mucosa, but its clinical utility remains unclear. This study aimed to evaluate FsG17 comprehensively: establish the ranges and cut-off points of FsG17 levels in different gastric diseases,... | 25,157,583 | [
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Drastic effect of lattice propionitrile molecules on the spin-transition temperature of a 2,2'-dipyridylamino/s-triazine-based iron(II) complex. | Reaction of iron(II) selenocyanate (obtained from Fe(ClO4)2 and KNCSe) with 2-(N,N-bis(2-pyridyl)amino)-4,6-bis(pentafluorophenoxy)-(1,3,5)triazine (L1(F)) in propionitrile produces the compound [Fe(L1(F))2(NCSe)2]·2CH3CH2CN (1(NCSe)·2PrCN), which shows spin-crossover (SCO) properties characterized by a T(1/2) of 283 K... | 25,157,585 | [
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... |
Superacidity in sulfated metal-organic framework-808. | Superacids, defined as acids with a Hammett acidity function H0 ≤ -12, are useful materials, but a need exists for new, designable solid state systems. Here, we report superacidity in a sulfated metal-organic framework (MOF) obtained by treating the microcrystalline form of MOF-808 [MOF-808-P: Zr6O5(OH)3(BTC)2(HCOO)5(H... | 25,157,587 | [
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0.1241904,
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... |
Standards for the uniform reporting of hypertension in adults using population survey data: recommendations from the World Hypertension League Expert Committee. | Surveillance and monitoring of cardiovascular risk factors including raised blood pressure are critical to informing efforts to prevent and control cardiovascular disease. Yet, many countries lack the capacity for adequate national surveillance. Furthermore, hypertension indicators are often reported in different ways,... | 25,157,607 | [
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0.001415755,
0.04701464,
0.07617076,
0.179335,
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Utilizing Behavioral Economics to Understand Adherence to Physical Activity Guidelines Among a Low-Income Urban Community. | Behavioral economics studies have found that individuals with more patient time preferences (ie, greater willingness to forgo current costs for future benefits) are more likely to save money. Although research has observed significant relationships between time preferences and health-promoting behaviors, scant evidence... | 25,157,611 | [
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0.1454178,
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Surface presentation of functional peptides in solution determines cell internalization efficiency of TAT conjugated nanoparticles. | Functionalizing nanoparticles with cell-penetrating peptides is a popular choice for cellular delivery. We investigated the effects of TAT peptide concentration and arrangement in solution on functionalized nanoparticles' efficacy for membrane permeation. We found that cell internalization correlates with the positive ... | 25,157,643 | [
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0.03817861,
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... |
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells. | The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of cisplatin paclitaxel and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibi... | 25,157,649 | [
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0.1118313,
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0.... |
Renal changes in the early stages of diet-induced obesity in ovariectomized rats. | The relationship between obesity and renal lesions, especially in low estrogen levels, has been less documented. The aim of this study was to assess the renal changes in diet-induced obesity in ovariectomized rats. Wistar rats were ovariectomized or sham-operated and divided into four groups: sham-operated rats fed a s... | 25,157,653 | [
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0.0848532,
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Transforming community services through the use of a multidimensional model of clinical leadership. | To evaluate the application of a Multidimensional Model of Clinical Leadership on the community healthcare leader and on transforming community services. Healthcare policy advocates clinical leadership as the vehicle to transform community and healthcare services. Few studies have identified the key components of an ef... | 25,157,691 | [
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0.2164355,
0.3829338,
... |
Prediction and characterization of MXene nanosheet anodes for non-lithium-ion batteries. | Rechargeable non-lithium-ion (Na(+), K(+), Mg(2+), Ca(2+), and Al(3+)) batteries have attracted great attention as emerging low-cost and high energy-density technologies for large-scale renewable energy storage applications. However, the development of these batteries is hindered by the limited choice of high-performan... | 25,157,692 | [
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0.3284947,
-0.09373171,
-0.241832... |
Co3O4 nanowires supported on 3D N-doped carbon foam as an electrochemical sensing platform for efficient H2O2 detection. | Using a simple hydrothermal procedure and a subsequent annealing treatment, one-dimensional (1D) cobalt oxide nanowires (Co3O4-NWs) with tunable size have been successfully in situ fabricated on a three-dimensional (3D) carbon foam (CF) network. By changing the hydrothermal treatment time (0.5, 1, or 2 h) at 180 °C, si... | 25,157,755 | [
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0.1286512,
0.1545164,
0.1740538,
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β-sheet-like hydrogen bonds interlock the helical turns of a photoswitchable foldamer to enhance the binding and release of chloride. | Inspired by halorhodopsin's use of photoisomerization to regulate chloride, aryltriazole-based foldamers have been created to "catch and release" chloride ions upon light irradiation of end-appended azobenzenes. The proposed mode of stabilization exploits a β-sheet-like hydrogen-bonding array to cooperatively interlock... | 25,157,797 | [
-0.2819883,
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0.2676293,
0.4601489,
0.08851576,
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0.... |
Preparation and identification of monoclonal antibody against Citreoviridin and development of detection by Ic-ELISA. | Citreoviridin (CIT), a neurotoxic mycotoxin produced by Penicillium citreonigrum is generally detected in cereal grains and agricultural products worldwide, and has numerous toxicological effects on human and animal health. Therefore, it is necessary to develop a rapid, sensitive, and reliable immunoassay method for CI... | 25,157,801 | [
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0.1718964,
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0.4730105,
0.06516301,
0.528773,
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Urinary Xist is a potential biomarker for membranous nephropathy. | Membranous nephropathy (MN), a type of glomerular nephritis, is the most common cause of nephrotic syndrome in human adults. Changes in gene expression as a result of epigenetic dysregulation through long noncoding RNAs (lncRNAs) are increasingly being recognized as important factors in disease. Using an experimental M... | 25,157,805 | [
0.1077154,
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0.2344474,
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-0.29... |
3,4-Dihydroxy-l-phenylalanine as a biomarker of oxidative damage in proteins: improved detection using cloud-point extraction and HPLC. | Oxidized protein adducts are formed under conditions of oxidative stress and may represent a valuable biomarker for a variety of diseases which share this common aetiology. A suitable candidate biomarker for oxidized proteins is protein-bound 3,4-dihydroxyl-l-phenylalanine (l-DOPA), which is formed on 3'-hydroxylation ... | 25,157,806 | [
-0.2631627,
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0.2502096,
0.132268,
0.1715367,
-0.371866,
-0.02... |
CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. | Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin and lung. Here, we used multiple murine models of cGVHD to investigate the contribution of macrophage populations in the development of cGVHD. Using an established... | 25,157,821 | [
-0.1572746,
-0.3628218,
-0.007279172,
-0.309922,
0.3821273,
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0.1176323,
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0.05566965,
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0.4882006,
-0.0... |
Biocontrol of Aspergillus species on peanut kernels by antifungal diketopiperazine producing Bacillus cereus associated with entomopathogenic nematode. | The rhabditid entomopathogenic nematode associated Bacillus cereus and the antifungal compounds produced by this bacterium were evaluated for their activity in reducing postharvest decay of peanut kernels caused by Aspergillus species in in vitro and in vivo tests. The results showed that B. cereus had a significant ef... | 25,157,831 | [
0.1031841,
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0.462819,
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... |
Post-embryo transfer interventions for assisted reproduction technology cycles. | In women undergoing in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), embryos transferred into the uterine cavity can be expelled due to many factors including uterine peristalsis and contractions, low site of deposition and negative pressure generated when removing the transfer catheter. Techni... | 25,157,849 | [
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-0.1385025,
-0.2048104,
0.2866586,
-0.02320413... |
Changes in free amino acid concentrations in the blood, brain and muscle of heat-exposed chicks. | An experiment was conducted to analyse the changes in free amino acid concentrations in the blood, brain and muscle of chicks in response to 15 or 30 min exposure to high ambient temperature (HT). Food intake and body weight were not affected, while rectal temperature was significantly increased by short-term HT exposu... | 25,157,850 | [
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0.1093435,
0.1368084,
0.4597466,
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Tuning the electronic coupling in Mo2-Mo2 systems by variation of the coordinating atoms of the bridging ligands. | Three novel [Mo2]-bridge-[Mo2] complexes were synthesized by a convergent assembling reaction of the dimetal precursor Mo2(DAniF)3(O2CCH3) (DAniF = N,N'-di(p-anisyl)formamidinate) with the bridging ligands terephthalamidine, terephthalamide and dithioterephthalamide. The structures of these compounds, [Mo2(DAniF)3]2[μ-... | 25,157,859 | [
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0.1617703,
0.1112158,
0.5452643,
0.1051303,
0.2083896,
-0.1100351... |
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