title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Novel oral anticoagulants in gastroenterology routine]. | Novel direct-acting oral anticoagulants (NOAC) represent an effective new familiy of drugs and an interesting alternative to optimise and simplify anticoagulation. Rates of bleeding complications by NOAC are comparabel to those of warfarin but a previously assumed increase in gastrointestinal bleeding complications was... | 25,157,869 | [
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Role of substrate positioning in the catalytic reaction of 4-hydroxyphenylpyruvate dioxygenase-A QM/MM Study. | Ring hydroxylation and coupled rearrangement reactions catalyzed by 4-hydroxyphenylpyruvate dioxygenase were studied with the QM/MM method ONIOM(B3LYP:AMBER). For electrophilic attack of the ferryl species on the aromatic ring, five channels were considered: attacks on the three ring atoms closest to the oxo ligand (C1... | 25,157,877 | [
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Effects of tibial plateau angle and spacer thickness applied during in vitro canine total knee replacement on three-dimensional kinematics and collateral ligament strain. | To quantify the 3-D kinematics and collateral ligament strain of stifle joints in cadaveric canine limbs before and after cranial cruciate ligament transection followed by total knee replacement (TKR) involving various tibial plateau angles and spacer thicknesses. 6 hemi-pelvises collected from clinically normal noncho... | 25,157,882 | [
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Effect of small interfering RNAs on in vitro replication and gene expression of feline coronavirus. | To evaluate the ability of small interfering RNAs (siRNAs) to inhibit in vitro viral replication and gene expression of feline coronavirus (FCoV). Cell cultures of Crandell-Rees feline kidney cells. 5 synthetic siRNAs that each targeted a different region of the FCoV genome were tested individually and in various combi... | 25,157,886 | [
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Clinical sensitivity and specificity of a real-time PCR assay for Campylobacter fetus subsp venerealis in preputial samples from bulls. | To determine clinical sensitivity and specificity of a quantitative real-time PCR (qRT-PCR) assay for Campylobacter fetus subsp venerealis (Cfv) in preputial samples of bulls. 313 beef bulls. Preputial samples were collected from 300 virgin bulls and 13 Cfv-infected bulls. Specificity of the qRT-PCR assay, determined o... | 25,157,889 | [
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Bacterial cellulose/acrylamide pH-sensitive smart hydrogel: development, characterization, and toxicity studies in ICR mice model. | The objective of this study is to synthesize and evaluate acute toxicity of the bacterial cellulose (BC)/acrylamide (Am) hydrogels as noncytotoxic and biocompatible oral drug delivery vehicles. A novel series of solubilized BC/Am hydrogels were synthesized using a microwave irradiation method. The hydrogels were charac... | 25,157,890 | [
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The mixed blessing of treating symptoms in acute vestibular failure--evidence from a 4-aminopyridine experiment. | Early symptomatic treatment of acute unilateral vestibulopathy is thought to impede the course of ensuing central vestibular compensation (VC). Despite the great clinical importance of this hypothesis there is no experimental evidence of its validity. The present study addressed this question by investigating the direc... | 25,157,903 | [
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Theoretical-computational modeling of photo-induced charge separation spectra and charge recombination kinetics in solution. | In this study we propose a theoretical-computational method, essentially based on molecular dynamics simulations and quantum-chemical calculations, for modelling the photo-induced charge separation (CS) and the subsequent charge recombination (CR) processes in solution. In particular we have reproduced the low-energy U... | 25,157,909 | [
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U.S. Adults' Participation in Specific Activities: Behavioral Risk Factor Surveillance System--2011. | There is little information on national estimates for participation in types of aerobic activities among U.S. adults. Current estimates are important to develop appropriate and effective interventions to promote physical activity and interpret bias for some activities measured with devices. The percentage of adults par... | 25,157,914 | [
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Self-assembly in Nafion membranes upon hydration: water mobility and adsorption isotherms. | By means of dissipative particle dynamics (DPD) and Monte Carlo (MC) simulations, we explored geometrical, transport, and sorption properties of hydrated Nafion-type polyelectrolyte membranes. Composed of a perfluorinated backbone with sulfonate side chains, Nafion self-assembles upon hydration and segregates into inte... | 25,157,931 | [
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Selecting the correct weighting factors for linear and quadratic calibration curves with least-squares regression algorithm in bioanalytical LC-MS/MS assays and impacts of using incorrect weighting factors on curve stability, data quality, and assay performance. | A simple procedure for selecting the correct weighting factors for linear and quadratic calibration curves with least-squares regression algorithm in bioanalytical LC-MS/MS assays is reported. The correct weighting factor is determined by the relationship between the standard deviation of instrument responses (σ) and t... | 25,157,966 | [
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Shear bond strength of orthodontic brackets to enamel after application of a caries infiltrant. | To examine differences in the shear bond strength of orthodontic brackets on differently mineralized enamel surfaces after applying a caries infiltrant or conventional adhesive. A total of 320 bovine incisors were assigned to eight pretreated groups, and the shear force required for debonding was recorded. Residual adh... | 25,157,972 | [
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Invasive pneumococcal isolates from Danish infants (0 - 90 Days) during the years 1943 to 2013. | The seven-valent pneumococcal conjugate vaccine (PCV-7) was introduced in the Danish childhood immunization program (at 3, 5 and 12 months of age) in 2007 and was replaced with PCV-13 in 2010 without changes to the schedule. After the introduction of these vaccines the incidence of invasive pneumococcal disease (IPD) d... | 25,157,997 | [
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Sexual assault reporting procedures at Ohio colleges. | To assess how Ohio colleges conform to recommendations that address barriers to reporting sexual assault. A study sample of Ohio 4-year colleges (N = 105). College Web sites were examined between March and November 2011 for their availability of sexual assault policies using 8 measures. Of the colleges in the sample, 6... | 25,158,011 | [
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'Above all, do no harm': safeguarding pluripotent stem cell therapy against iatrogenic tumorigenesis. | Human pluripotent stem cells are the foundations of regenerative medicine. However, the worst possible complication of using pluripotent stem cells in therapy could be iatrogenic cancerogenesis. Nevertheless, despite the rapid progress in the development of new techniques for induction of pluripotency and for directed ... | 25,158,017 | [
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Whole exome sequencing of extreme morbid obesity patients: translational implications for obesity and related disorders. | Whole-exome sequencing (WES) is a new tool that allows the rapid, inexpensive and accurate exploration of Mendelian and complex diseases, such as obesity. To identify sequence variants associated with obesity, we performed WES of family trios of one male teenager and one female child with severe early-onset obesity. Ad... | 25,158,045 | [
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Multiple sclerosis: changes in microarchitecture of white matter tracts after training with a video game balance board. | To determine if high-intensity, task-oriented, visual feedback training with a video game balance board (Nintendo Wii) induces significant changes in diffusion-tensor imaging ( DTI diffusion-tensor imaging ) parameters of cerebellar connections and other supratentorial associative bundles and if these changes are relat... | 25,158,046 | [
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Observational studies: getting clear about transparency. | The PLOS Medicine Editors endorse four measures to ensure transparency in the analysis and reporting of observational studies. Please see later in the article for the Editors' Summary. | 25,158,064 | [
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The use of time lapse photography in an in vitro fertilization programme for better selection for embryo transfer. | The time lapse photography is not a new method for assessing the dynamics of early embryo development in vitro. It has been used many times in the past for studying cleavages and blastulation of embryos of various animal species. However, this technique became available for routine use in an human in vitro fertilizatio... | 25,158,088 | [
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Chondroprotection using naturally occurring mineral supplementation formula in degenerative osteoarthritis of the knees. | To evaluate the therapeutic and safety efficacy of a naturally occurring mineral supplementation in the treatment of symptomatic knee osteoarthritis (OA). A prospective, single centre, study of 50 patients aged 50 years and above with painful and radiological Osteoarthritis of knees was carried out for one year. Patien... | 25,158,090 | [
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Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. | Voltage-gated sodium channels (Na(V)s) provide the initial electrical signal that drives action potential generation in many excitable cells of the brain, heart, and nervous system. For more than 60years, functional studies of Na(V)s have occupied a central place in physiological and biophysical investigation of the mo... | 25,158,094 | [
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Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype. | Experimentally naïve outbred rats display varying rates of locomotor reactivity in response to the mild stress of a novel environment. Namely, some display high rates (HR) whereas some display low rates (LR) of locomotor reactivity. Previous reports from our laboratory show that HRs, but not LRs, develop locomotor sens... | 25,158,103 | [
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Identification of sialylated glycoproteins in Doxorubicin-treated hepatoma cells with glycoproteomic analyses. | Sialylation is one of the most important types of glycosylation involved in carcinogenesis and establishment of cancer stemness. We previously showed that increased sialylation is a characteristic glycan change in cancer stem cells (CSCs) from hepatocellular carcinoma. However, the identities of glycoproteins targeted ... | 25,158,113 | [
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Clinical and metabolic parameters in non-small cell lung carcinoma and colorectal cancer patients with and without KRAS mutations. | Lung cancer (LC) and colorectal cancer (CRC) are the first and second deadliest types of cancer worldwide. EGFR-based therapy has been used in the treatment of these cancers with variable success. Presence of mutations in the KRAS driver oncogene, possibly induced by environmental factors such as carcinogens in diet an... | 25,158,139 | [
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Quantifying the impact of decay in bed-net efficacy on malaria transmission. | Insecticide-treated nets (ITNs) are at the forefront of malaria control programs and even though the percentage of households in sub-Saharan Africa that owned nets increased from 3% in 2000 to 53% in 2012, many children continue to die from malaria. The potential impact of ITNs on reducing malaria transmission is limit... | 25,158,163 | [
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Establishment of Singleton-Merten syndrome pulp cells: evidence of mineralization dysregulation. | Singleton-Merten syndrome (SMS) is a rare disease with a phenotype of dental dysplasia. Currently, the underlying mechanism of this disease is unknown. In order to investigate the functional mechanism of the SMS tooth phenotypes, we isolated dental pulp tissue and established SMS primary pulp cells. These cells exhibit... | 25,158,182 | [
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Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. | Runx2 and Sp7 transcription factors are essential for skeletogenesis. Targeted deletion of either gene results in failure of osteoblast differentiation and bone formation. Loss of bone-matrix gene expression is surprisingly similar in Sp7 and Runx2 null mice. The molecular mechanisms responsible for similar transcripti... | 25,158,187 | [
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Ultrastructural organization of dentin in mice lacking dentin sialo-phosphoprotein. | Dentin Sialophosphoprotein (DSPP) is the major non-collagenous protein of dentin and plays a significant role in dentin mineralization. Recently, animal models lacking DSPP have been developed and the DSPP KO phenotype has been characterized at the histological level. Little is known, however, about the DSPP KO dentin ... | 25,158,189 | [
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0.1733855,
0.1775... |
Runx2 activity in committed osteoblasts is not essential for embryonic skeletogenesis. | Runx2 transcription factor is essential for the development of mineralized tissue, and is required for osteoblast commitment and chondrocyte maturation. Mice with global deletion of Runx2 exhibit complete failure of bone tissue formation, while chondrocyte-specific Runx2-deficient mice lack endochondral ossification. H... | 25,158,191 | [
0.1255998,
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Ameloblastin as a putative marker of specific bone compartments. | Ameloblastin (AMBN), a member of the enamel matrix protein family, has been recently identified as integral part of the skeleton beyond the enamel. However, the specific role of endogenous AMBN in bone tissue is not fully elucidated. This study aims at investigating mRNA expression of AMBN in wild-type mice in differen... | 25,158,194 | [
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A retrospective study on changes in residents' physical activities, social interactions, and neighborhood cohesion after moving to a walkable community. | This study is to examine changes in residents' physical activities, social interactions, and neighborhood cohesion after they moved to a walkable community in Austin, Texas. Retrospective surveys (N=449) were administered in 2013-2014 to collect pre- and post-move data about the outcome variables and relevant personal,... | 25,158,208 | [
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A modified acidic approach for DNA extraction from plant species containing high levels of secondary metabolites. | Purified genomic DNA can be difficult to obtain from some plant species because of the presence of impurities such as polysaccharides, which are often co-extracted with DNA. In this study, we developed a fast, simple, and low-cost protocol for extracting DNA from plants containing high levels of secondary metabolites. ... | 25,158,268 | [
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A G₄·K⁺ hydrogel stabilized by an anion. | Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ratio of borate anion to ligand is crucial for gelation as it links ... | 25,158,285 | [
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0.007772063,
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Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. | Recent reports highlighted the role of histone deacetylases (HDACs) in the pathogenesis of diabetic nephropathy (DN), but the exact molecular mechanisms by which HDAC inhibitors ameliorate DN still remain unclear. The present study was aimed to investigate the renoprotective effects of sodium butyrate (NaB) in diabetes... | 25,158,305 | [
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Speech-language therapy for adolescents with written-language difficulties: the South African context. | To investigate whether privately practising speech-language therapists in South Africa are fulfilling their role of identification, assessment and intervention for adolescents with written-language and reading difficulties. Further needs concerning training with regard to this population group were also determined. A s... | 25,158,374 | [
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[Diagnosis and evolution of scabies]. | Human scabies is an ectoparasitosis affecting any individual at any age. The level of infestation by Sarcoptes scabiei var. hominis is influenced by any defect in immune response. Several clinical types of scabies are described including baby scabies, profuse scabies of immunodepression, norvegian scabies and sarcoptic... | 25,158,389 | [
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Breast density legislation. Implications for patients and primary care providers. | Minnesota recently became the 16th state to require facilities that perform mammograms to notify patients if they are found to have dense or extremely dense breasts, as this may make it more difficult to detect a cancer or put them at increased risk for cancer. This article outlines the new law and describes the classi... | 25,158,436 | [
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[Study on transition metals in airborne particulate matter in Shanghai city's subway]. | PM10 and PM2.5 aerosol particle samples were collected at a subway station in Shanghai and their morphology, chemical composition and transition metal species were studied. The mass concentrations of PM10 and PM2.5 inside the subway station were significantly higher than those measured in aboveground ambient air. The P... | 25,158,477 | [
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[Influence of different disturbance intensity on the phosphorus adsorption and immobilization by the sediments from an inner city heavily polluted canal]. | The mechanism of phosphorus (P) adsorption and immobilization under different disturbance intensities was investigated in laboratory. The sediments and water used were taken from an inner-city heavily polluted canal. Addition of KH2PO4 into the experimental units were made similar to the external P input into the canal... | 25,158,492 | [
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[Delivery and release of sediment PAHs during resuspension]. | The resuspension of sediment after being disturbed is simulated by particle entrainment simulator (PES). The conclusions came out as follows. Sediment nature like granulometric composition and sediment PAHs richness markedly affected the release of PAHs. During the resuspension experiment, the total suspended solids (T... | 25,158,494 | [
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[Impacts of filamentous bulking on treatment effect and fouling characteristics of nonwoven bioreactor]. | Sludge flocs morphology and effluent qualities of nonwoven bioreactor during filamentous bulking and normal sludge status were compared. Flux variations, analysis of filtration resistances and extracellular polymer substances (EPS) contents during filamentous bulking and normal sludge status were studied. The results s... | 25,158,502 | [
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[Risk assessment and countermeasures of BTEX contamination in soils of typical pesticide factory]. | Soil samples around three representative pesticide factories were collected in Zhangjiakou City, Hebei Province, and analyzed to identify their pollution characteristics and health risk of BTEX by purge-and trap and gas chromatography/mass spectroscopy method. Total concentrations of BTEX in soils in Plant A, B and C r... | 25,158,506 | [
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[Levels distribution and risk assessment of the indicator and dioxin-like polychlorinated biphenyls in ten different species of marine fish of Bohai Bay, China]. | Polychlorinated biphenyls (PCBs) are highly lipohilic compounds with high metabolic persistence and toxicity. PCBs tend to accumulate in the aquatic food chain and make fish a source of various environmental toxicants to humans. Industries in the Bohai Bay include iron and steel smelting, cement manufacturing and waste... | 25,158,507 | [
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[Detection of biohazardous materials in water upon the characteristics of fluorescent sensor Frex]. | Luminescent bacteria have attracted more and more attention in recent years as an effective mean for biological toxicity of water environment monitoring. First of all, fluorescent protein Frex was correctly expressed in Escherichia coli, and then the effect of toxic substances on microbial metabolism in the water was m... | 25,158,508 | [
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[Methanogenic activity and methanogen diversity in marine gas field sediments]. | Methanogens play an important role in marine sediments, which are related to methane production and methane hydrate deposits. Methanogenic activity of marine gas field sediments was investigated using substrates that methanogens usually used as carbon sources. H2/CO2, methanol, methylamines and trimethylamines could su... | 25,158,513 | [
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[Linguistic validation of Japanese version of Prolapse/Urinary Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR)]. | To translate the Prolapse/Urinary Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR) into Japanese and evaluate the linguistic validation of the translated PISQ-IR. The translation and evaluation of PISQ-IR were performed through 3 steps: forward translation based on 2 urologists and discussed by another 4 urolo... | 25,158,552 | [
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0.3070681,
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... |
[Cross-cultural validated adaptation of dysfunctional voiding symptom score (DVSS) to Japanese language and cognitive linguistics in questionnaire for pediatric patients]. | Validated questionnaire for evaluation of pediatric lower urinary tract symptoms (LUTS) is of a great need. We performed cross-cultural validated adaptation of Dysfunctional Voiding Symptom Score (DVSS) to Japanese language, and assessed whether children understand and respond to questionnaire correctly, using cognitiv... | 25,158,553 | [
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[The accuracy of evaluating the response of metastatic lymph nodes after concurrent chemoradiotherapy in patients with head and neck squamous cell carcinoma]. | Concurrent chemoradiotherapy (CCRT) is used to treat advanced head and neck cancer. The accuracy of evaluating lymph nodes metastases following CCRT is important for subsequent therapy. Patients were divided into two groups according to the nodal status, the complete response (CR) and the non-CR groups, as determined b... | 25,158,559 | [
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[Surgical approach of lateral temporal bone resection for treatment of head and neck cancer with invasion surrounding the jugular foramen]. | We herein present a review of the surgical approach of lateral temporal bone resection (LTBR) in the treatment of 5 cases of head and neck cancers invading the jugular foramen between 2008 to 2013. The patients comprised 3 males and 2 females with ages ranging from 25 to 76 and observation times were between 13 and 22 ... | 25,158,562 | [
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A CAPE analogue as novel antiplatelet agent efficiently inhibits collagen-induced platelet aggregation. | Platelet activation plays a pivotal role in the pathogenesis of thrombosis, which can lead to fatal diseases such as myocardial or cerebral infarction, and atherosclerosis. The present study focused on investigating the effect of CAPE-NO2 against collagen-induced platelet aggregation. Caffeic acid phenethyl ester (CAPE... | 25,158,573 | [
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Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. | Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatm... | 25,158,576 | [
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[Invasive community-acquired infections in children]. | The study group consisted of 180 patients who had 186 community-acquired blood-culture positive infections during 2007-June 2013. Three of them died of meningitis caused by S. pneumoniae or N. meningitidis. A ten-valent conjugated pneumococcal vaccine was introduced in the Finnish National Vaccine Program in 2010. Afte... | 25,158,584 | [
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Fetal cardiac function measured by myocardial performance index of small-for-gestational age fetuses. | The aim of this study was to demonstrate the changes of right and left myocardial performance indices (MPI) in small-for-gestational age (SGA) fetuses during 28-40 weeks of gestation. Singleton pregnant women during 28-40 weeks of gestation were enrolled. Estimated fetal weight was used to classify the subjects into ap... | 25,158,601 | [
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0.108423,
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Diet quality is associated with measures of body fat in adolescents from Otago, New Zealand. | To examine the potential associations between diet quality and multiple measures of body composition in a sample of New Zealand adolescents aged 14-18 years. Cross-sectional survey of eleven high schools in Otago, New Zealand. Each participant completed an online FFQ and a New Zealand Diet Quality Index for Adolescents... | 25,158,609 | [
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The socioeconomic impact of hearing loss in U.S. adults. | To evaluate the associations between hearing loss and educational attainment, income, and unemployment/underemployment in U.S. adults. National cross-sectional survey. Ambulatory examination centers. Adults aged 20 to 69 years who participated in the 1999 to 2002 cycles of the NHANES (National Health and Nutrition Exam... | 25,158,616 | [
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0.00421187,... |
Use of sulfur-oxidizing bacteria as recognition elements in hydrogen sulfide biosensing system. | Four sulfur-oxidizing bacteria (Thiobacillus thioparus, Acidithiobacillus thiooxidans PTCC1717, Acidithiobacillus ferrooxidans PTCC1646, and Acidithiobacillus ferrooxidans PTCC1647) were used as biorecognition elements in a hydrogen sulfide biosensing system. All the experiments were performed in 0.1 M phosphate buffer... | 25,158,614 | [
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Factors related to clinician attitudes toward prolonged exposure therapy for PTSD. | This study examines pretraining attitudes toward prolonged exposure (PE) therapy in a sample of 1,275 mental health clinicians enrolled in a national PE training program sponsored by the U.S. Department of Veterans Affairs. Attitudes assessed via survey included values placed on outcomes targeted by PE, outcome expecta... | 25,158,635 | [
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A qualitative analysis of the experience and impact of killing in hand-to-hand combat. | A growing body of research suggests that killing during military combat is closely associated with posttraumatic stress disorder (PTSD), as well as a number of other adverse mental health related conditions (e.g., dissociative experiences, violent behavior, functional impairment). This article provides first-person per... | 25,158,640 | [
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The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations. | Despite a high degree of structural homology and shared exchange factors, effectors and GTPase activating proteins, a large body of evidence suggests functional heterogeneity among Ras isoforms. One aspect of Ras biology that may explain this heterogeneity is the differential subcellular localizations driven by the C-t... | 25,158,650 | [
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An instructional DVD fall-prevention program for patients with cancer and family caregivers. | Determine the efficacy of a fall-prevention skills training program for patients with cancer and family caregivers. Randomized, controlled trial with repeated measures and postintervention measure of fall occurrence. A comprehensive cancer center in the midwestern United States. 132 patient and family caregiver dyads. ... | 25,158,654 | [
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Microbial communities evolve faster in extreme environments. | Evolutionary analysis of microbes at the community level represents a new research avenue linking ecological patterns to evolutionary processes, but remains insufficiently studied. Here we report a relative evolutionary rates (rERs) analysis of microbial communities from six diverse natural environments based on 40 met... | 25,158,668 | [
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The effects of high glucose levels on reactive oxygen species-induced apoptosis and involved signaling in human vascular endothelial cells. | This study investigated the effects of high glucose levels on human vascular endothelial cells and the expression of apoptosis-associated signaling molecules. Cell proliferation of human umbilical vein endothelial cells (HUVECs) was analyzed by colorimetric assay and cell number counting. Apoptosis was measured by Anne... | 25,158,671 | [
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Noncontact, low-frequency ultrasound therapy enhances neovascularization and wound healing in diabetic mice. | Chronic wounds are a major source of morbidity for patients and represent a significant health burden. Implementing noninvasive techniques that accelerate healing of these wounds would provide great benefit. Ultrasound appears to be an effective modality for the treatment of chronic wounds in humans. MIST Therapy is a ... | 25,158,717 | [
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[New concepts in aligner therapy with the orthocaps system]. | Orthodontic tooth movement with aligners poses challenges peculiar to removable appliances. The mechanical limitations of aligners can be overcome, to some extent, by increasing the aligner grip on teeth as well as by choosing elastic materials in their fabrication. Sound planning together with the use of auxiliaries c... | 25,158,748 | [
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Large area and depth-profiling dislocation imaging and strain analysis in Si/SiGe/Si heterostructures. | We demonstrate the combined use of large area depth-profiling dislocation imaging and quantitative composition and strain measurement for a strained Si/SiGe/Si sample based on nondestructive techniques of electron beam-induced current (EBIC) and X-ray diffraction reciprocal space mapping (XRD RSM). Depth and improved s... | 25,158,752 | [
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NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia. | The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor-mediated excitotoxici... | 25,158,771 | [
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Paracetamol-induced Stevens Johnson syndrome and cholestatic hepatitis. | Stevens-Johnson syndrome (SJS) is an uncommon life-threatening skin disease, generally induced by drugs. Extracutaneous manifestations of the syndrome can occur, and may involve the conjunctiva, buccal mucosa, gastrointestinal and genitourinary tracts. Cholestatic hepatitis has been rarely described in SJS. A 29-year-o... | 25,158,788 | [
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Drosophila suzukii: the genetic footprint of a recent, worldwide invasion. | Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here, we investigate the genetic population str... | 25,158,796 | [
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A comparison of high resolution melting, allele-specific priming and Sanger sequencing for the detection of BRAFV600E mutation in hairy cell leukaemia from different haematological specimens. | The BRAFV600E mutation is a highly sensitive and specific marker for the diagnosis of hairy cell leukaemia (HCL) and a potential therapeutic target. We assessed the performance of high resolution melting (HRM), allele-specific priming (ASP) and Sanger sequencing (SS) for BRAFV600E detection in 17 unenriched samples fro... | 25,158,814 | [
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A survey of Australian haematology reference intervals. | This study was designed to create a snapshot of Australian haematology reference intervals (RIs) in use, in particular red cell parameters. We present an analysis of survey results conducted across Australian laboratories between November 2012 and January 2013.All Australian laboratories enrolled in the Royal College o... | 25,158,822 | [
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Quantitative assessment of p-glycoprotein expression and function using confocal image analysis. | P-glycoprotein is implicated in clinical drug resistance; thus, rapid quantitative analysis of its expression and activity is of paramout importance to the design and success of novel therapeutics. The scope for the application of quantitative imaging and image analysis tools in this field is reported here at "proof of... | 25,158,832 | [
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[Scorpion envenomation treated in the Infectious and Tropical Diseases at the Donka National Hospital, Guinea]. | A retrospective descriptive study was conducted from 1(st) October 2010 to 30 November 2012 on the records of patients admitted for scorpion envenomation in the Department of Infectious and Tropical Diseases at the Donka National Hospital. The objective of this study is to describe the epidemiological profile and clini... | 25,158,841 | [
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[Seroprevalence of HBs Ag and of anti-HCV antibodies among HIV infected people in N'Djamena, Chad]. | This is a prospective study conducted as part of a voluntary testing for HBV, HCV and HIV. The aim of the study is to determine the seroprevalence of HBs Ag and anti-HCV antibodies among HIV infected people and a control group of HIV negative people. HIV prevalence among newly diagnosed volunteers is 9.1%. The overall ... | 25,158,842 | [
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[Descriptive analysis of Plasmodium falciparum malaria in an expatriate community in Yaounde-Cameroon]. | Malaria is an endemic disease in Cameroon. Expatriate population is also affected by malaria risk. Many studies are published on malaria, but few are focused on the expatriate population. The objective was to describe epidemiological characteristics andmanagement ofmalaria at Plasmodium falciparum in Yaounde expatriate... | 25,158,843 | [
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Neuronal osmotransduction: push-activating TRPV1 with microtubules. | Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, which... | 25,158,850 | [
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Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth. | Rab GTPases, by targeting to specific membrane compartments, play essential roles in membrane trafficking. Lipid droplets (LDs) are dynamic subcellular organelles whose growth is closely linked to obesity and hepatic steatosis. Fsp27 is shown to be required for LD fusion and growth by enriching at LD-LD contact sites. ... | 25,158,853 | [
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Reconstruction of the nasal infratip, columella, and soft triangle. | Tumors of the soft triangle and distal nose are common, and the wounds created when removing them are among the more challenging defects to repair. Reconstruction of the soft triangle, infratip, and columella requires attention to form and function beyond what is usually needed in cutaneous surgery. The complexities of... | 25,158,877 | [
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Advanced reconstruction of the ear: a framework for successful wound closure. | The ear is a complex and intricate feature of the human face in which reconstruction after oncologic excision is predicated on the complete removal of skin cancer. Reconstructive strategies are based on an understanding of the hierarchy of aesthetic concerns for the ear. Review of the reconstructive strategies for reco... | 25,158,879 | [
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The Na(+) transporter, TaHKT1;5-D, limits shoot Na(+) accumulation in bread wheat. | Bread wheat (Triticum aestivum L.) has a major salt tolerance locus, Kna1, responsible for the maintenance of a high cytosolic K(+) /Na(+) ratio in the leaves of salt stressed plants. The Kna1 locus encompasses a large DNA fragment, the distal 14% of chromosome 4DL. Limited recombination has been observed at this locus... | 25,158,883 | [
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Will metformin postpone high-fat diet promotion of TRAMP mouse prostate cancer development and progression? | We aimed to examine the effect of high-fat diet (HFD) on prostate cancer (PCa) development and progression and to investigate whether metformin would postpone PCa development and progression promoted by HFD. TRAMP mice were randomly divided into three groups: normal diet group, HFD group and metformin-HFD (Met-HFD) gro... | 25,158,895 | [
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Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents. | Complex sensations accompany the activation of sensory neurons within the respiratory system, yet little is known about the organization of sensory pathways in the brain that mediate these sensations. In the present study, we employ anterograde viral neuroanatomical tract tracing with isogenic self-reporting recombinan... | 25,158,901 | [
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Solvent annealing of perovskite-induced crystal growth for photovoltaic-device efficiency enhancement. | Solvent-annealing is found to be an effective method to increase the grain size and carrier diffusion lengths of trihalide perovskite materials. The carrier diffusion length of MAPbI3 is increased to over 1 μm. The efficiency remains above 14.5% when the MAPbI3 thickness changes from 250 nm to 1 μm, with the highest ef... | 25,158,905 | [
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Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. | Neocortical interactions with the dorsal striatum support many motor and executive functions, and such underlying functional networks are particularly vulnerable to a variety of developmental, neurological, and psychiatric brain disorders, including autism spectrum disorders, Parkinson's disease, and Huntington's disea... | 25,158,904 | [
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0.4418215,
0.1337924,
-0.485931,
-0.1904933,
-0.02755842,
-0.3644592,
0.259717,
-0.3085908,
-0.07690645,
0.2735536,
0.2715281,
0.09394041,
-0... |
Swing traction versus no-traction for complex intra-articular proximal inter-phalangeal fractures. | Traction orthoses are thought to optimize recovery from intra-articular finger fractures by restoring joint space and allowing early motion. Evidence to date has, however, consisted only of case series. To compare swing traction versus no-traction management of complex fractures of proximal inter-phalangeal (PIP) finge... | 25,158,903 | [
-0.3221847,
0.2182293,
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0.06545524,
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0.09820616,
-0.1351084,
-0.004349088,
-0.219... |
Entrustment of general surgery residents in the operating room: factors contributing to provision of resident autonomy. | Several challenges threaten the traditional premise of graduated independence in general surgery training, leading to a lack of readiness in graduating surgeons. The objective of this study was to determine the factors contributing to faculty decisions to grant residents autonomy in the operating room, the barriers to ... | 25,158,911 | [
-0.2052522,
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0.009112302,
0.02047337,
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... |
Positive psychological determinants of treatment adherence among primary care patients. | Patient adherence to medical treatment recommendations can affect disease prognosis, and may be beneficially or deleteriously influenced by psychological factors. Aim We examined the relationships between both adaptive and maladaptive psychological factors and treatment adherence among a sample of primary care patients... | 25,158,934 | [
-0.06505588,
0.1172181,
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0.1282419,
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0.08607807,
0.1030156,
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0.3751588,
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0.1266425,
-0.3746342,
-0.04343715,
-0.082456... |
Quality versus accuracy: result of a reanalysis of protein-binding microarrays from the DREAM5 challenge by using BayesPI2 including dinucleotide interdependence. | Computational modeling transcription factor (TF) sequence specificity is an important research topic in regulatory genomics. A systematic comparison of 26 algorithms to learn TF-DNA binding specificity in in vitro protein-binding microarray (PBM) data was published recently, but the quality of those examined PBMs was n... | 25,158,938 | [
-0.1241242,
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0.1969547,
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0.01792076,
0.206118,
0.2623608,
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Effect of lens status in the surgical success of 23-gauge primary vitrectomy for the management of rhegmatogenous retinal detachment: the Pan American Collaborative Retina Study (PACORES) group results. | To determine the effects of lens status on the success rate of primary pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment using either perfluoropropane gas (C3F8) or silicone oil (SO) tamponade. A retrospective chart analysis was made of 97 eyes from 92 patients with rhegmatogenous retinal detachment wit... | 25,158,939 | [
0.04938456,
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0.2725772,
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0.182033,
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0.01939288,
0.02941816,
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0.3227845,
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0.2207316,
0.2928806,
0.2125973,
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0.3581839,
-0.1339981,
-... |
Prevalence of thrombophilic genetic factors among patients with retinitis pigmentosa. | To determine the prevalence of thrombophilic factors in patients with retinitis pigmentosa (RP). Fifty consecutive patients with RP and 50 controls matched by age and gender were tested for the presence of the following mutations: factor II (GA20210), factor V Leiden (GA1691), methylenetetrahydrofolate reductase (CT677... | 25,158,941 | [
0.1987557,
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0.1244154,
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0.5533473,
0.1403769,
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0.05269353,
0.04515986,
0.4044569,
-0.3183439,
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0.2543839,
0.2080426,
0.225226,
-0.01365709,
0.627623,
-0.2725585,
0.302... |
p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints. | The tumor suppressor p53 (TP53) has a well-studied role in triggering cell-cycle checkpoint in response to DNA damage. Previous studies have suggested that functional p53 enhances chemosensitivity. In contrast, data are presented to show that p53 can be required for cell survival following DNA damage due to activation ... | 25,158,956 | [
-0.05621478,
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0.06241407,
0.2007386,
0.1736263,
0.1911324,
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0.1434752,
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0.08241708,
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0.03217887,
0.09262494,
0.252062,
0.260989,
0.1857475,
-0.08519554,
... |
A four-season molecule: osteocalcin. Updates in its physiological roles. | Osteocalcin (OC) is the main non-collagenous hydroxyapatite-binding protein synthesized by osteoblasts, odontoblasts, and hypertrophic chondrocytes. It has a regulatory role in mineralization and it is considered a marker of bone cell metabolism. Recent findings evidenced new extra-skeletal roles for OC, depicting it a... | 25,158,976 | [
-0.1767017,
0.3869399,
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0.07543472,
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0.2890858,
0.2109583,
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0.3586862,
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0.02573663,
0.175847,
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0.3711656,
0.2623657,
-0.2864227,
... |
Evaluation of a localization training program for hearing impaired listeners. | To evaluate the effectiveness of a home-based and a laboratory-based localization training program. This study examined the effectiveness of a localization training program on improving the localization ability of 15 participants with a mild-to-moderately severe hearing loss. These participants had worn the study heari... | 25,158,980 | [
-0.1069645,
0.3241007,
0.1595639,
0.05791447,
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-0.03436602,
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0.3703703,
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0.1478978,
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0.143994,
0.0729063,
0.02682612,
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0.1350849,
-0.3280372,
-0.3001332,
-0.01282292,
0.3862502,
0.09721883,
... |
Molecular basis and bleeding manifestations of factor XI deficiency in 11 Turkish families. | Factor XI (FXI) deficiency is an autosomal bleeding disorder characterized by variable bleeding tendency. In the present study, the gene encoding FXI (F11) was analyzed by direct sequencing in 33 individuals belonging to 11 unrelated Turkish families, and the bleeding tendency was quantitatively assessed by means of a ... | 25,158,988 | [
0.06672046,
0.1792718,
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0.0108533,
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0.1233962,
0.2882451,
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0.1676089,
0.5062315,
0.6331673,
-0.09784458,
... |
Lung hyperinflation in chronic obstructive pulmonary disease: mechanisms, clinical implications and treatment. | Lung hyperinflation is highly prevalent in patients with chronic obstructive pulmonary disease and occurs across the continuum of the disease. A growing body of evidence suggests that lung hyperinflation contributes to dyspnea and activity limitation in chronic obstructive pulmonary disease and is an important independ... | 25,159,007 | [
0.006475953,
0.1891886,
0.111293,
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0.01057496,
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-0.3370444,
0.01913393,
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-0.03324973,
0.2298542,
0.07437213,
-0.1823602,
-0.3194005,
0.1861461,
-0.226211... |
Diminishing relative contraindications for immediate breast reconstruction: a multicenter study. | During the past decade, there has been a rise in US breast reconstruction rates, with a greater expansion in prosthetic-based techniques relative to autologous transfer. Immediate reconstruction in high-risk oncologic and surgical patients might be a contributing factor to these trends. The National Cancer Data Base fr... | 25,159,019 | [
0.0420257,
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0.3636764,
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0.05220497,
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0.2304466,
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0.2873899,
0.1721086,
0.1375569,
... |
Pretargeted imaging using bioorthogonal chemistry in mice. | Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy... | 25,159,021 | [
-0.2602864,
-0.03949054,
-0.09495014,
-0.09237652,
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0.186854,
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0.169275,
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0.02228517,
0.262132,
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0.3373491,
0.01784446,
0.04231843,
0.1100609,
0.1146152,
-0.158691... |
Intent-to-adhere and adherence to malaria prevention recommendations in two travel clinics. | Malaria infects 30,000 travelers annually worldwide. At greatest risk are those who travel for long duration. Prevention of malaria includes chemoprophylaxis. This prospective study on 121 travelers who visited two travel clinics shows that adherence to prophylactic treatment was low, especially in long duration trips,... | 25,159,037 | [
-0.09084193,
0.173651,
-0.2282931,
-0.1260248,
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-0.2726804,
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0.05478469,
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0.03739179,
0.1642468,
0.2131123,
0.02440432,
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-0.2929841,
0.2176204,
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0.1209461,
-0.07105925,
0.001386461,
-0.2003395... |
Hope versus hype: what can additive manufacturing realistically offer trauma and orthopedic surgery? | Additive manufacturing (AM) is a broad term encompassing 3D printing and several other varieties of material processing, which involve computer-directed layer-by-layer synthesis of materials. As the popularity of AM increases, so to do expectations of the medical therapies this process may offer. Clinical requirements ... | 25,159,068 | [
-0.4573994,
0.2634346,
-0.04155986,
0.2013407,
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0.3181239,
0.04117344,
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0.1686871,
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0.03992501,
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-0.01832648,
0.01409758,
-0.4286068,
-0.04492817,
0.273923,
0.09744852,
-0.09173589,... |
Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target? | Phosphodiesterase 11A (PDE11A) is the most recently discovered 3', 5'-cyclic nucleotide phosphodiesterase. By breaking down both cAMP and cGMP, PDE11A is a critical regulator of intracellular signaling. To date, PDE11A has been implicated to play a role in tumorigenesis, brain function, and inflammation. Here, we conso... | 25,159,071 | [
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0.1277416,
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0.2092652,
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0.1661966,
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-0.06036521,
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0.09006464,
0.1850546,
0.1344108,
-0.143157... |
Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview. | Phosphodiesterase inhibitors (PDE-Is) enhance cAMP and/or cGMP signaling via reducing the degradation of these cyclic nucleotides. Since both cAMP and cGMP signaling are essential in a variety of cellular functions, including neuroplasticity and neuroprotection, PDE-Is are receiving increased attention as possible targ... | 25,159,073 | [
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0.1913242,
0.02777526,
0.1716435,
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0.1012128,
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0.3212176,
-0.02802893,
0.1629579,
0.09831814,
0.2528311,
-0.0929558,
... |
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