title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Short-term effects of bright light therapy in adults with chronic nonspecific back pain: a randomized controlled trial. | The present trial evaluated incorporation of bright light therapy in the treatment of chronic nonspecific back pain (CNBP). A prospective, randomized, controlled, multicenter, open design with three parallel trial arms was used. Subjects received a novel therapeutic, an expected therapeutic ineffective low dose, or no ... | 25,159,085 | [
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In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. | The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape-based virtual modeling tech... | 25,159,092 | [
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Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats. | Androstenedione, the main circulating ovarian hormone present after menopause, has been shown to positively correlate with poor spatial memory in an ovary-intact rodent model of follicular depletion, and to impair spatial memory when administered exogenously to surgically menopausal ovariectomized rats. Androstenedione... | 25,159,107 | [
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Genomic organization, differential expression, and functional analysis of the SPL gene family in Gossypium hirsutum. | SQUAMOSA promoter binding protein-like (SPL) genes encode plant-specific transcription factors that are involved in many fundamental developmental processes. Certain SPL genes contain sequences complementary to miR156, a microRNA (miRNA) that plays a role in modulating plant gene expression. In this study, 30 SPL genes... | 25,159,110 | [
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Inferring population structure and demographic history using Y-STR data from worldwide populations. | The Y chromosome is one of the best genetic materials to explore the evolutionary history of human populations. Global analyses of Y chromosomal short tandem repeats (STRs) data can reveal very interesting world population structures and histories. However, previous Y-STR works tended to focus on small geographical ran... | 25,159,112 | [
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DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication. | DEP domain-containing mTOR-interacting protein (DEPTOR) has been recently discovered as an endogenous regulator of the mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2. mTORC1 is present in the brain, and there is growing evidence that its dysregulation contributes to several brain alterations. This sugges... | 25,159,114 | [
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Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver. | Computationally supported development of small molecule inhibitors has successfully been applied to protein tyrosine phosphatases in the past, revealing a number of cell-active compounds. Similar approaches have also been used to screen for small molecule inhibitors for the cancer-related phosphatases of regenerating l... | 25,159,123 | [
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Fluorochrome-based definition of naturally occurring Foxp3(+) regulatory T cells of intra- and extrathymic origin. | Under physiological conditions, studies on the biology of naturally induced Foxp3(+) Treg cells of intra- and extrathymic origin have been hampered by the lack of unambiguous markers to discriminate the mature progeny of such developmental Treg-cell sublineages. Here, we report on experiments in double-transgenic mice,... | 25,159,127 | [
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IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model. | We earlier found that TNFα but not interleukin (IL)-17 is indispensable in the pathogenesis of spontaneously occurring rheumatoid arthritis (RA)-like disease in our newly established FcγRIIB-deficient C57BL/6 (B6) mouse model, designated KO1. Here, we examined the role of IL-6 in the pathogenesis of RA features in KO1,... | 25,159,156 | [
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Highly magneto-responsive multilayer microcapsules for controlled release of insulin. | In this study, magneto-responsive polyelectrolyte multilayer microcapsules were successfully prepared by the formation of shell with biocompatible iron oxide nanoparticles (Fe₃O₄ NPs) and polyallylamine hydrochloride (PAH) by layer-by-layer (LbL) self-assembly technique. The self-assembled microcapsules were characteri... | 25,159,178 | [
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Highlights from the ASCO Genitourinary Symposium 2014: focus on renal and prostate cancer. | The genitourinary cancer symposium is one of the most important conferences focused on cancers of the prostate, penis, urethra, testes, bladder and kidney. This year the genitourinary symposium celebrated 10 years – its theme was 'integrating biology into patient-centric care'. The conference offered educational sessio... | 25,159,199 | [
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Management of biliary complications in 412 patients with liver injuries. | Bile leaks occur in 4% to 23% of patients after major liver injuries. The role of conservative management versus internal biliary drainage has not been clearly defined. The safety and efficacy of nonoperative management of bile leaks were studied. Four hundred twelve patients with liver injuries were assessed in a pros... | 25,159,249 | [
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The multi-channel cochlear implant: multi-disciplinary development of electrical stimulation of the cochlea and the resulting clinical benefit. | This multi-disciplinary research showed sound could be coded by electrical stimulation of the cochlea and peripheral auditory nervous system. But the temporal coding of frequency as seen in the experimental animal, was inadequate for the important speech frequencies. The data indicated the limitation was due in particu... | 25,159,273 | [
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Carbohydrate dynamics and mortality in a piñon-juniper woodland under three future precipitation scenarios. | Drought-induced forest mortality is an increasing global problem with wide-ranging consequences, yet mortality mechanisms remain poorly understood. Depletion of non-structural carbohydrate (NSC) stores has been implicated as an important mechanism in drought-induced mortality, but experimental field tests are rare. We ... | 25,159,277 | [
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Atrial fibrillation and coronary artery disease: which antithrombotic treatment strategy? | The optimal antithrombotic therapy in patients with atrial fibrillation and coronary artery disease is controversial. The benefit of the combination of antithrombotic therapies remains debatable, and, as the bleeding risk is substantial, this calls for knowledge of the duration, and which and how many agents should be ... | 25,159,278 | [
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Hybrid approach for coronary artery revascularization: where do we stand? | Recently, hybrid coronary artery revascularization (HCAR), combining the benefits of both percutaneous coronary intervention and coronary artery bypass graft surgery (CABG) while minimizing their respective shortcomings, has been developed. This review is aimed to explore and discuss recent clinical outcomes and patien... | 25,159,279 | [
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The effects of constant flow bioreactor cultivation and keratinocyte seeding densities on prevascularized organotypic skin grafts based on a fibrin scaffold. | Organotypic full-thickness skin grafts (OTSG) are already an important technology for treating various skin conditions and are well established for skin research and development. These obvious benefits are often impaired by the need of laborious production, their noncomplete autologous composition, and, most importantl... | 25,159,286 | [
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Influence of pressure changes on recruitment pattern and neck muscle activities during Cranio-Cervical Flexion Tests (CCFTs). | The muscle activity of the deep cervical flexors is emphasized more than that of the superficial cervical flexors, and it has been reported that functional disorders of the longuscolli are found in patients who experience neck pain. The objective of this study was to analyze the recruitment patterns and muscle activiti... | 25,159,290 | [
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Circulating mitochondrial DNA level, a noninvasive biomarker for the early detection of gastric cancer. | Gastric cancer represents a major health burden worldwide and is often diagnosed at an advanced stage. Biomarkers for screening and prevention of gastric cancer are missing. Changes in peripheral blood mitochondrial DNA (mtDNA) have emerged as a potential preventive/diagnosis biomarker for cancer risk. We aimed to dete... | 25,159,292 | [
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Comparative genomics and transcriptomics in ants provide new insights into the evolution and function of odorant binding and chemosensory proteins. | The complex societies of ants and other social insects rely on sophisticated chemical communication. Two families of small soluble proteins, the odorant binding and chemosensory proteins (OBPs and CSPs), are believed to be important in insect chemosensation. To better understand the role of these proteins in ant olfact... | 25,159,315 | [
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Physiology or psychic powers? William Carpenter and the debate over spiritualism in Victorian Britain. | This paper analyses the attitude of the British Physiologist William Benjamin Carpenter (1813-1885) to spiritualist claims and other alleged psychical phenomena in the second half of the Nineteenth Century. It argues that existing portraits of Carpenter as a critic of psychical studies need to be refined so as to inclu... | 25,159,318 | [
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Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. | Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops. Along with this, poor encapsulation efficiency of hydrophilic drug in polymeric nanoparticles remains a major formulation challe... | 25,159,319 | [
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Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia. | Meal-fed (MF) rats with access to food for only 4 consecutive hours during the light cycle learn to eat large meals to maintain energy balance. MF animals develop behavioral and endocrine changes that permit glucose tolerance despite increased meal size. We hypothesized that enhanced activity of the enteroinsular axis ... | 25,159,330 | [
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Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. | The steroid receptor coactivator 1 (SRC1) regulates key metabolic pathways, including glucose homeostasis. SRC1(-/-) mice have decreased hepatic expression of gluconeogenic enzymes and a reduction in the rate of endogenous glucose production (EGP). We sought to determine whether decreasing hepatic and adipose SRC1 expr... | 25,159,329 | [
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Health status and health services utilization in elderly Koreans. | Korea is aging faster than any other country as the 'baby boomers' grow older. The purpose of this study is to describe the health status and health services utilization of older Koreans and examine the factors that are associated with effective health services utilization. Based on the 2008 Korean Longitudinal Study o... | 25,159,331 | [
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The use of rigid eye shields (Fox shields) at the point of injury for ocular trauma in Afghanistan. | Unlike hemorrhagic injuries in which direct pressure is indicated, any pressure placed on the eye after penetrating trauma can significantly worsen the injury by expulsing intraocular contents. The accepted first response measure for obvious or suspected penetrating ocular injury is placement of a rigid shield that vau... | 25,159,350 | [
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Continuous noninvasive respiratory volume monitoring for the identification of patients at risk for opioid-induced respiratory depression and obstructive breathing patterns. | Opioid-induced respiratory depression (OIRD) and postoperative apnea (POA) can lead to complications after surgery or traumatic injury. Previously, real-time monitoring of respiratory insufficiency and identification of apneic events have been difficult. A noninvasive respiratory volume monitor (RVM) that reports minut... | 25,159,358 | [
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Amnesic shellfish poisoning biotoxin detection in seawater using pure or amino-functionalized Ag nanoparticles and SERS. | Domoic acid (DA) biotoxin responsible for the amnesic shellfish poisoning (ASP) has been unambiguously detected in seawater in a broad range of concentration, with both pure and amino-functionalized Ag nanoparticles employed for surface enhanced Raman scattering (SERS). To achieve this, a comprehensive SERS study on DA... | 25,159,386 | [
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0.04775658,
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0.4883938,
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In situ trapping of As, Sb and Se hydrides on nanometer-sized ceria-coated iron oxide-silica and slurry suspension introduction to ICP-OES. | A procedure is developed for the analysis of sub-μg L(-1) levels of arsenic, antimony and selenium after preconcentration of their hydrides. The study highlights the capability of an aqueous suspension of a nanometer-sized magnetic ceria, in the presence of iodide, to function as a sorbent for the in situ trapping and ... | 25,159,391 | [
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Evaluation of total reducing power of edible oils. | The lipophilicity of untreated edible oils narrows the application of most published methods for the determination of antioxidant activity to hydrophilic extracts of oils. This research addresses the issue of the estimation of the total antioxidant properties of untreated edible oils by modifying two widely applied ana... | 25,159,404 | [
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Molecular interactions between some non-steroidal anti-inflammatory drugs (NSAID's) and bovine (BSA) or human (HSA) serum albumin estimated by means of isothermal titration calorimetry (ITC) and frontal analysis capillary electrophoresis (FA/CE). | The interactions between some non-steroidal anti-inflammatory drugs, NSAIDs, (naproxen, ibuprofen and flurbiprofen) and bovine (BSA) or human (HSA) serum albumin have been examined by means of two complementary techniques, isothermal titration calorimetry (ITC) and frontal analysis/capillary electrophoresis (FA/CE). It... | 25,159,405 | [
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Capillary electrophoresis coupled with automated fraction collection. | A fraction collector based on a drop-on-demand ink-jet printer was developed to interface capillary zone electrophoresis with a 96 well microtiter plate. We first evaluated the performance of the collector by using capillary zone electrophoresis to analyze a 1mM solution of tetramethylrhodamine; a fluorescent microtite... | 25,159,411 | [
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Near infrared spectral imaging for the analysis of dynamite residues on human handprints. | This study examines the utility of near infrared hyperspectral imaging (NIR-HSI) combined with chemometrics for the detection of dynamite residues on human handprints. Polyvinyl sheets containing dynamite residues were then analysed with the NIR-HSI system. A spectral library was developed by using partial least square... | 25,159,415 | [
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L-cysteine protected copper nanoparticles as colorimetric sensor for mercuric ions. | This report demonstrates a novel, simple and efficient protocol for the synthesis of copper nanoparticles in aqueous solution using L-cysteine as capping or protecting agent. UV-visible (UV-vis) spectroscopy was employed to monitor the LSPR band of L-cysteine functionalized copper nanoparticles (Cyst-Cu NPs) based on o... | 25,159,429 | [
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Multivariate statistical comparison of analytical procedures for benzene and phenol determination with respect to their environmental impact. | The study describes the possibility of application of self-organizing maps technique to assess the greenness of analytical methodologies. The metrological and "environmental impact" parameters of procedures for benzene and phenol determination in water samples were sets of input data for chemometric analysis. Totally 4... | 25,159,434 | [
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Monte Carlo simulation of expert judgments on human errors in chemical analysis--a case study of ICP-MS. | Monte Carlo simulation of expert judgments on human errors in a chemical analysis was used for determination of distributions of the error quantification scores (scores of likelihood and severity, and scores of effectiveness of a laboratory quality system in prevention of the errors). The simulation was based on modeli... | 25,159,436 | [
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Simultaneous determination of dorzolomide and timolol in aqueous humor: a novel salting out liquid-liquid microextraction combined with HPLC. | A Snovel method for the simultaneous separation and determination of two antiglaucoma drugs namely, dorzolamide hydrochloride (DOR) and timolol maleate (TIM) in aqueous humor samples (AH) was developed by using salting-out assisted liquid-liquid microextraction (SALLME) combined with HPLC-UV method. Box-Behnken experim... | 25,159,439 | [
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0.1376064,... |
Nuclear fast red as highly sensitive "off/on" fluorescent probe for detecting guanine. | A novel fluorescence method for the determination of guanine was developed based on the fluorescence enhancement of Cu(2+)-nuclear fast red complex in the presence of guanine in Tris-HCl buffer. The complex of Cu(2+) with nuclear fast red resulted in a dramatic quenching of the fluorescence intensity. Nuclear fast red ... | 25,159,443 | [
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Evaluation of image quality of DWIBS versus DWI sequences in thoracic MRI at 3T. | To compare diffusion weighted imaging with background suppression (DWIBS) sequence with classic spectral diffusion sequence (DWI) with and without respiratory gating in mediastinal lymph node analysis at 3T. 26 patients scheduled for mediastinoscopic lymph node analysis, prospectively undergone a thoracic 3T MRI with D... | 25,159,472 | [
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Cytochrome P450 2D6*10 genotype affects the pharmacokinetics of dimemorfan in healthy Chinese subjects. | This study aimed to investigate the effects of cytochrome P450 2D6*10 (100C > T, rs1065852) genotype on the pharmacokinetics of dimemorfan in healthy Chinese subjects. Data were evaluated from 24 subjects in two pharmacokinetic studies who received an oral dose of 40 mg of dimemorfan syrup (n = 12) or dimemorfan tab... | 25,159,483 | [
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Synthesis and reduction-responsive disassembly of PLA-based mono-cleavable micelles. | Stimuli-responsive block copolymers and their self-assembled nanostructures have been extensively studied as effective building blocks in construction of various nanomaterials in nanoscience and nanotechnology. A promising stimuli-responsive platform involves an incorportion of reduction-responsive disulfide linkages t... | 25,159,511 | [
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A microarray platform and novel SNP calling algorithm to evaluate Plasmodium falciparum field samples of low DNA quantity. | Analysis of single nucleotide polymorphisms (SNPs) derived from whole-genome studies allows for rapid evaluation of genome-wide diversity, and genomic epidemiology studies of Plasmodium falciparum provide insights into parasite population structure, gene flow, drug resistance and vaccine development. In areas with adeq... | 25,159,520 | [
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Assessment of ovarian cancer conditions from exhaled breath. | We present a pilot study that aims to examine the possibility to easily and noninvasively detect and discriminate females with ovarian cancer (OC) from females that have no tumor(s) and from females that have benign genital tract neoplasia, using exhaled breath samples. The study is based on clinical samples and data f... | 25,159,530 | [
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Nanostructured porous Si optical biosensors: effect of thermal oxidation on their performance and properties. | The influence of thermal oxidation conditions on the performance of porous Si optical biosensors used for label-free and real-time monitoring of enzymatic activity is studied. We compare three oxidation temperatures (400, 600, and 800 °C) and their effect on the enzyme immobilization efficiency and the intrinsic stabil... | 25,159,537 | [
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... |
Management of acute calcific tendinitis around the hip joint. | Although the natural history of calcific tendinitis within the rotator cuff of the shoulder is established, the natural history of calcific tendinitis around the hip joint remains unknown. To examine the duration of symptoms including pain, the location of calcific tendinitis around the hip joint, the radiologic course... | 25,159,540 | [
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School-based prevention program associated with increased short- and long-term retention of safety knowledge. | Validation of program effectiveness is essential in justifying school-based injury prevention education. Although Risk Watch (RW) targets burn, fire, and life safety, its effectiveness has not been previously evaluated in the medical literature. Between 2007 and 2012, a trained fire service public educator (FSPE) taugh... | 25,159,554 | [
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0.2402... |
Interest of functional foods for low-income countries. | To understand the interest of functional food in low-income countries by analyzing various necessary factors. Being on a low income would appear to relate most often to an unbalanced diet, both qualitatively and quantitatively, which may be damaging to health in the long term. Most chronic diseases of concern today are... | 25,159,560 | [
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... |
Synthesis of copper/nickel nanoparticles using newly synthesized Schiff-base metals complexes and their cytotoxicity/catalytic activities. | Transition metal complexes compounds with Schiff bases ligand representing an important class of compounds that could be used to develop new metal-based anticancer agents and as precursors of metal NPs. Herein, 2,3-bis-[(3-ethoxy-2-hydroxybenzylidene)amino]but-2-enedinitrile Schiff base ligand and its corresponding cop... | 25,159,596 | [
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... |
Beneficial effect of splanchnic nerve transection and harmful effect of vagotomy on acute necrotizing pancreatitis in the dog. | The nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. However, the influence of visceral nerve (VN) on acute necrotizing pancreatitis (ANP) has drawn little attention. To investigate the influence of VN on the pathophysiological process of ANP in d... | 25,159,609 | [
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How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells. | Ribonucleotides are misincorporated into replicating DNA due to the similarity of deoxyribonucleotides and ribonucleotides, the high concentration of ribonucleotides in the nucleus and the imperfect accuracy of replicative DNA polymerases in choosing the base with the correct sugar. Embedded ribonucleotides change cert... | 25,159,610 | [
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... |
Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery. | The RNA component of signal recognition particle (SRP) is transcribed by RNA polymerase III, and most steps in SRP biogenesis occur in the nucleolus. Here, we examine processing and quality control of the yeast SRP RNA (scR1). In common with other pol III transcripts, scR1 terminates in a U-tract, and mature scR1 retai... | 25,159,613 | [
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40S recruitment in the absence of eIF4G/4A by EMCV IRES refines the model for translation initiation on the archetype of Type II IRESs. | Initiation of translation on Type II IRESs, such as those of EMCV and FMDV viruses, has been well documented in the recent years. For EMCV, the current model argues for a mechanism in which the key interaction necessary for the pre-initiation complex recruitment is eIF4G binding to the central J-K domains of EMCV-IRES.... | 25,159,618 | [
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Minimally invasive surgical techniques are safe in the diagnosis and treatment of pediatric malignancies. | Minimally invasive surgical (MIS) techniques have become an established part of the care of the adult oncology patient. As surgeons have become more experienced with these advances in technique, MIS has recently seen an expanding role in the diagnosis and treatment of pediatric malignancies. We hypothesize that MIS tec... | 25,159,642 | [
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Robotic left colon cancer resection: a dual docking technique that maximizes splenic flexure mobilization. | Techniques for robotic resection of the left colon are not well defined and have not been widely adopted due to limited range of motion of the robotic arms. We have developed a dual docking technique for both the splenic flexure and the pelvis. We report our initial experience of robotic left colectomy using this techn... | 25,159,646 | [
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Laparoscopic limited Heller myotomy without anti-reflux procedure does not induce significant long-term gastroesophageal reflux. | Laparoscopic Heller myotomy with partial fundoplication is the gold standard treatment for achalasia. Laparoscopic limited Heller myotomy (LLHM) with no anti-reflux procedure is another possible option. A review of prospectively collected data was performed on patients who underwent LLHM from January 1998 to December 2... | 25,159,656 | [
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Human ApoE ε4 alters circadian rhythm activity, IL-1β, and GFAP in CRND8 mice. | Disruptions to daily living, inflammation, and astrogliosis are characteristics of Alzheimer's disease. Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillary acidic protein (GFAP) were examined in a mouse model developed to model late-onset Alzheimer's disease-the most common form of the dis... | 25,159,669 | [
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Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer's disease. | There is growing recognition that cerebral hypoperfusion is related to the pathogenesis of Alzheimer's disease (AD), implicating the measurement of cerebral blood flow (CBF) as a possible biomarker of AD. The ability to identify the earliest and most reliable markers of incipient cognitive decline and clinical symptoms... | 25,159,672 | [
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Waterpipe use and cognitive susceptibility to cigarette smoking among never-cigarette smoking Jordanian youth: analysis of the 2009 Global Youth Tobacco Survey. | Susceptibility to cigarette smoking, defined as lack of a firm decision to not initiate smoking, predicts youth smoking initiation and experimentation and is a first step in the transition to regular smoking. This study investigated whether waterpipe (WP) smoking, an increasingly prevalent form of tobacco use among Ara... | 25,159,679 | [
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Personalizing risk stratification by addition of PAK1 expression to TNM staging: improving the accuracy of clinical decision for gastroesophageal junction adenocarcinoma. | Gastroesophageal junction adenocarcinoma (GEJA) is an aggressive malignancy with an alarmingly rising incidence. TNM staging is widely used by oncologists to stratify prognosis as well as direct therapeutic strategies. However, inadequate lymphadenectomy is frequently encountered for GEJA and largely confounds prognosi... | 25,159,681 | [
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Nursing Under the Old Poor Law in Midland and Eastern England 1780-1834. | This article uses data drawn from the overseers' accounts and supporting documentation in thirty-six parishes spread over four English counties, to answer three basic questions. First, what was the character, extent, structure, range of activities, and remuneration of the nursing labor force under the Old Poor Law betw... | 25,159,685 | [
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Improving the genetic representation of rare taxa within complex microbial communities using DNA normalization methods. | Complex microbial communities typically contain a large number of low abundance species, which collectively, comprise a considerable proportion of the community. This 'rare biosphere' has been speculated to contain keystone species and act as a repository of genomic diversity to facilitate community adaptation. Many en... | 25,159,704 | [
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First-trimester screening biochemical markers (free beta-subunit human chorionic gonadotropin, pregnancy-associated plasma protein-A) and risk of early fetal loss. | The aim of this work was to assess the risk of early fetal loss (first trimester of pregnancy, 8-13 weeks of gestation) using the results of first-trimester screening (FTS) biochemical markers independently and combined. FTS results of 152 women who suffered early fetal loss were compared to a control group of 150 wome... | 25,159,705 | [
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International approaches to Indigenous dental care: what can we learn? | Indigenous populations around the world have significantly poorer oral health and inequalities in access to dental care largely attribute to the social determinants of health. Reviewing international literature offers an opportunity to better understand appropriate approaches for policy and practice in Australia. This ... | 25,159,709 | [
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Examining the function in sitting test for validity, responsiveness, and minimal clinically important difference in inpatient rehabilitation. | To determine the responsiveness of the Function In Sitting Test (FIST), compare scores at admission and discharge from inpatient rehabilitation (IPR) with other balance and function measures, and determine the minimal clinically important difference (MCID). Prospective, nonblinded, reference-standard comparison study. ... | 25,159,714 | [
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That eagle covering me: transitioning and connected autonomy for emerging adults with cystinosis. | Rare diseases pose transitioning challenges owing to limited provider expertise and changing healthcare systems. The timeframe and developmental changes of emerging adulthood overlap with the transition of patients with cystinosis from pediatric to adult-oriented healthcare. This study utilized techniques of qualitativ... | 25,159,720 | [
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Nontraditional risk factors for cardiovascular disease and visceral adiposity index among different body size phenotypes. | Increased cardiovascular disease and mortality risk in metabolically healthy obese (MHO) individuals remain highly controversial. Several studies suggested risk while others do not. The traditional cardiovascular risk factors may be insufficient to demonstrate the complete range of metabolic abnormalities in MHO indivi... | 25,159,728 | [
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Occurrence of decabromodiphenyl ethane in captive Chinese alligators (Alligator sinensis) from China. | Decabromodiphenyl ethane (DBDPE), a replacement for decabromodiphenyl ether (deca-BDE), was investigated in captive Chinese alligators from China. DBDPE was detected in adult tissues, neonates and eggs of Chinese alligators with concentrations ranging from 4.74-192, 0.24-1.94, and 0.01-0.51 ng g(-1) lipid weight, respe... | 25,159,734 | [
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Comparing neuroprotective effects of CDNF-expressing bone marrow derived mesenchymal stem cells via differing routes of administration utilizing an in vivo model of Parkinson's disease. | The potential value of cerebral dopamine neurotrophic factor (CDNF) in treating Parkinson's disease (PD) remains controversial. To evaluate the therapeutic effects of CDNF-expressing bone marrow derived mesenchymal stem cell (CDNF-MSCs) injections in a rat model of Parkinson's disease, we chose three different routes o... | 25,159,816 | [
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Antioxidant, antibacterial and cytotoxic potential of the ripe fruits of Solanum lycocarpum A. St. Hil. (Solanaceae). | Ethanol extract (EE) and fractions obtained from the ripe fruits of Solanum lycocarpum were examined in order to determine their phenolic composition, antioxidant capacity, antibacterial activities and cytotoxic potential. High-performance liquid chromatography coupled with DAD analysis indicated that caffeic and chlor... | 25,159,821 | [
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Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution. | Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution. We perform whole exome sequencing on four clear cell renal cell carcinomas removed from both kidneys of a patient with a germline VHL mutation. We report that tumor... | 25,159,823 | [
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Pulse-chase analysis of procollagen biosynthesis by azidohomoalanine labeling. | Disruptions in procollagen synthesis, trafficking and secretion by cells occur in multiple connective tissue diseases. Traditionally, these disruptions are studied by pulse-chase labeling with radioisotopes. However, significant DNA damage, excessive accumulation of reactive oxygen species and formation of other free r... | 25,159,826 | [
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Screening of synthetic phage display scFv libraries yields competitive ligands of human leptin receptor. | Initially considered the main endogenous anorexigenic factor, fat-derived leptin turned out to be a markedly pleiotropic hormone, influencing diverse physiological processes. Moreover, hyperleptinemia in obese individuals has been linked to the onset or progression of serious disorders, such as cancer, autoimmune disea... | 25,159,846 | [
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Resistance through inhibition: ectopic expression of serine protease inhibitor offers stress tolerance via delayed senescence in yeast cell. | Protease inhibitors have been known to confer multiple stress tolerance in transgenic plants. We have assessed growth of yeast (Pichia pastoris GS115) strains expressing inhibitory repeat domains (PpIRD(+)) of previously characterized Capsicum annuum protease inhibitors under high salt, heavy metal and oxidative stress... | 25,159,848 | [
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Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. | Methylcytosine (5mC) is mostly symmetrically distributed in CpG sites. Ten-eleven-translocation (TET) proteins are the key enzymes involved in active DNA demethylation through stepwise oxidation of 5mC. However, oxidation pathways of TET enzymes in the symmetrically methylated CpG context are still elusive. Employing t... | 25,159,856 | [
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Interrelationship between bone substitution materials and skeletal muscle tissue. | Bone density and quantity are primary conditions for the insertion and stability of dental implants. In cases of a lack of adequate maxillary or mandibulary bone, bone augmentation will be necessary. The use of synthetic bioactive bone substitution materials is of increasing importance as alternatives to autogenously b... | 25,159,858 | [
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Sociodemographic and clinical correlates of migrant status in adults with psychotic disorders: data from the Australian Survey of High Impact Psychosis. | The links between migrant status and psychosis have attracted considerable attention in recent decades. The aim of the study was to explore the demographic and clinical correlates of migrant v. Australia-born status in individuals with psychotic disorders using a large community-based sample. Data were drawn from a pop... | 25,159,855 | [
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Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. | To study the ability of aqueous extract of Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats. Aqueous extract of Hericium erinaceus was given by daily oral administration following peroneal nerve crush injury in Sprague-Dawley rats. The expression of prot... | 25,159,861 | [
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Antecedent predictors of children's initiation of sipping/tasting alcohol. | Sipping or tasting alcohol is one of the earliest alcohol-use behaviors in which young children engage, yet there is relatively little research on this behavior. Previous cross-sectional analyses determined that child sipping or tasting is associated with the child's attitude toward sipping and with a family environmen... | 25,159,887 | [
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Fidelity of delivery of a physical activity intervention: predictors and consequences. | Assessing fidelity of behavioural interventions is important, but demanding and rarely done. This study assessed adherence to behaviour change techniques used in an intervention to increase physical activity among sedentary adults ( ProActive ; N = 365). Transcripts of 108 sessions with a sub-sample of 27 participants ... | 25,159,904 | [
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School-based, randomised controlled trial of an evidence-based condom promotion leaflet. | A condom use promotion leaflet was designed for use with older teenagers in schools. The text targeted a series of cognitive and behavioural antecedents of condom use identified in the literature. Given previous evidence that motivational incentives can enhance the effectiveness of health promotion leaflets, the leafle... | 25,159,906 | [
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Drawing ability in typical and atypical development; colour cues and the effect of oblique lines. | Individuals with Williams syndrome (WS) have poor drawing ability. Here, we investigated whether colour could be used as a facilitation cue during a drawing task. Participants with WS and non-verbal ability matched typically developing (TD) children were shown line figures presented on a 3 by 3 dot matrix, and asked to... | 25,159,922 | [
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Nurses' involvement in developing NICE guidelines. | This article discusses the development of National Institute for Health and Care Excellence guidelines, the contribution made by nurses to the guidelines and the importance of continuing to take an active role in this work. The challenges nurses face and the support provided to nurses involved in this work by the Royal... | 25,159,976 | [
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Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ. | The transcription factor NF-κB is one of the main players involved in inflammatory responses during which NF-κB becomes rapidly activated. However to maintain homeostasis, this NF-κB activation profile is only transient. Nevertheless deregulation of NF-κB activity is often observed and can lead to chronic inflammatory ... | 25,159,986 | [
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0.3300392,
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0.1752759,
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0.1948777,
0.2843108,
-0.02365404,
-0.1895383,
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0.04383491,
-0.1492708,
0.3123288,
0.1140537,
0.2980509,
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... |
Genetic and epigenetic variation in vulvar cancer: current research and future clinical practice. | Vulvar cancer is a relatively rare gynaecological malignancy, the treatment of which is associated with significant patient morbidity. With reports that the incidence of vulvar cancer is increasing, there is a rising need for improved preventive, diagnostic and therapeutic tools. Recent advances within genetics and epi... | 25,159,988 | [
-0.00079127,
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0.07261959,
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0.4691847,
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Antigenic homogeneity of male Müllerian gland (MG) secretory proteins of a caecilian amphibian with secretory proteins of the mammalian prostate gland and seminal vesicles: evidence for role of the caecilian MG as a male accessory reproductive gland. | Whereas in all other vertebrates the Müllerian ducts of genetic males are aborted during development, under the influence of Müllerian-inhibiting substance, in the caecilian amphibians they are retained as a pair of functional glands. It has long been speculated that the Müllerian gland might be the male accessory repr... | 25,160,003 | [
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0.02772698,
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0.2352092,
0.1236773,
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... |
Incidence and associated factors of difficult tracheal intubations in pediatric ICUs: a report from National Emergency Airway Registry for Children: NEAR4KIDS. | To evaluate the incidence and associated risk factors of difficult tracheal intubations (TI) in pediatric intensive care units (PICUs). Using the National Emergency Airway Registry for Children (NEAR4KIDS), TI quality improvement data were prospectively collected for initial TIs in 15 PICUs from July 2010 to December 2... | 25,160,031 | [
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Introduction to RNA-Seq and its applications to drug discovery and development. | Preclinical Research RNA sequencing (RNA-Seq) is a novel high-throughput technology for comprehensive transcriptome study. It can measure the expression levels of thousands of genes simultaneously and provide insight into functional pathways and regulations in biological processes. In addition, RNA-Seq can provide copi... | 25,160,072 | [
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0.189223,
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Congenital vulnerability of cutaneous segments arising from skin mosaicism: A genetic basis for locus minoris resistentiae. | Mosaicism is a biologic phenomenon that describes an individual who has two or more populations of cells with distinct genotypes and concomitant patterned phenotypes (eg, lines of Blaschko). It is distinguished from chimerism by its derivation from a single fertilized egg rather than multiple cell lineages derived from... | 25,160,099 | [
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... |
Granulomatous dysimmune reactions (sarcoidosis, granuloma annulare, and others) on differently injured skin areas. | Granulomatous disorders are chronic cell-mediated immune responses histologically characterized by collections of macrophages, epithelioid cells, and multinucleated giant cells. This disease spectrum often has an infectious origin, but sometimes neither an infective agent nor an inciting antigenic stimulus can be ident... | 25,160,106 | [
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Between students' instrumental goals and how they learn: goal content is the gap to mind. | Experimental/correlational studies have consistently demonstrated that the contents of an individual's goals play an important role within future motivations, learning processes, and outcomes. The aim of the study was to extend past findings by employing a three-point, cross-lagged latent simultaneous structural model ... | 25,160,115 | [
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0.2600497,
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0.343096,
0.1273971,
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... |
The sarcoidal granuloma: A unifying hypothesis for an enigmatic response. | Although the cause of sarcoidosis is unknown, there is growing support for the concept that sarcoidal granulomas result from a hypersensitivity reaction producing a nonspecific response to an extrinsic or intrinsic (autoimmune) antigen in genetically susceptible individuals. The immune milieu associated with these anti... | 25,160,107 | [
0.1598794,
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0.4996246,
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0.1229606,
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... |
Embracing case management for computerization of care pathways. | The computerization of care pathways (CPs) has drawn considerable attention, for improving quality of health care and reducing costs. A well-known big challenge of implementing CPs is their flexibility and ad hoc variations in execution of clinical tasks. We observe that case management suits well to address this probl... | 25,160,134 | [
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-0.2563981,
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0.1166108,
-0.248... |
Towards evidence-based CDSSs implementing the medical reasoning contained in CPGs: application to antibiotic prescription. | Clinical practice guidelines (CPGs) are documents giving recommendations based on expert reasoning, weighing up the pros and cons of treatments on the basis of the available evidence. We propose a new approach to the construction of clinical decision support systems (CDSS), making use of the evidence-based medical reas... | 25,160,136 | [
-0.2680065,
0.1341287,
0.1494454,
0.2046982,
0.165763,
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0.1622156,
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0.1552396,
0.1318243,
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... |
Arranging ISO 13606 archetypes into a knowledge base. | To enable the efficient reuse of standard based medical data we propose to develop a higher level information model that will complement the archetype model of ISO 13606. This model will make use of the relationships that are specified in UML to connect medical archetypes into a knowledge base within a repository. UML ... | 25,160,140 | [
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-0.07202952,
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0.2721533,
-0.1289039,
-0.2134248,
... |
Explicit evidence for prognostic Bayesian network models. | Many prognostic models are not adopted in clinical practice regardless of their reported accuracy. Doubts about the basis of the model is considered to be a major reason for this as the evidence behind clinical models is often not clear to anyone other than their developers. We propose a framework for representing the ... | 25,160,144 | [
0.0811324,
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0.3843652,
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0.3624077,
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0.1807054,
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0... |
A novel personal health system with integrated decision support and guidance for the management of chronic liver disease. | A personal health system platform for the management of patients with chronic liver disease that incorporates a novel approach to integrate decision support and guidance through care pathways for patients and their doctors is presented in this paper. The personal health system incorporates an integrated decision suppor... | 25,160,150 | [
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0.1097988,
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0.12623,
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Plug-and-play Integration of dual-model based Knowledge Artefacts into an Open Source Ehr System. | In this paper we present our experiences with extending an existing approach for an archetype-compliant collection and export of data according to the openEHR specifications within the open source EHR system OpenMRS. It allows an automatic generation of forms from templates, which were introduced by openEHR as an exten... | 25,160,154 | [
-0.1776155,
0.06036705,
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0.1830308,
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0.3359458,
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Interpretable associations over DataCubes: application to hospital managerial decision making. | The world concern about the costs of the health care systems has raised the importance of counting on precise and interpretable tools, that help the health care institution's managers to make decisions to optimize the use of health resources. In this paper we propose a new Classification based on Association Rules (CAR... | 25,160,160 | [
-0.07229895,
0.2051516,
0.289325,
0.3104814,
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0.07645699,
0.03842263,
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0.09246838,
-0.06516442,
-0.206131... |
Preservation of information in terminology transcoding. | Linking interface terminologies (IT) to reference terminologies (RT) in flow of terminologies may allow health information system to be both usable and interoperable. Two French university hospitals worked independently on such a flow from the prescription of lab-test to the display of the corresponding results. The ai... | 25,160,165 | [
0.03177598,
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0.2216752,
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0.05632267,
0.3100486,
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An approach for utilizing clinical statements in HL7 RIM to evaluate eligibility criteria. | The HL7 RIM (Reference Information Model) is a commonly used standard for the exchange of clinical data and can be employed for integrating the patient care and clinical research domains. Yet it is not sufficiently well specified to ensure a canonical representation of structured clinical data when used for the automat... | 25,160,189 | [
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0.09916855,
-0.02777369,
0.01163179,
0.144915,
0.2811568,
0.1086283,
... |
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