title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Learning from an Ambient Assisted Living Lab: the case of the intelligent bed. | This paper presents methodological lessons learned from an Ambient Assisted Living (AAL) lab exploring the use of intelligent beds in a nursing home. The living lab study was conducted over a period of three month. 20 intelligent beds were installed. Data was collected via self-registration, diaries, observations, inte... | 25,160,198 | [
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A workflow model to analyse pediatric emergency overcrowding. | The greatest source of delay in patient flow is the waiting time from the health care request, and especially the bed request to exit from the Pediatric Emergency Department (PED) for hospital admission. It represents 70% of the time that these patients occupied in the PED waiting rooms. Our objective in this study is ... | 25,160,202 | [
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Integrating personalized health information from MedlinePlus in a patient portal. | The objective of this paper is to describe the implementation and use of context aware information in Spanish from MedlinePlus embedded in a Patient Portal. Personalized information can help patients solve problems, make treatment decisions, gain confidence in their ability to care for themselves and communicate with p... | 25,160,204 | [
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Longitudinal data driven study design. | In this paper we present a method for processing EHR data into a longitudinal data model and examples for using this model to identify patients cross-sectionally and longitudinally as well as testing study designs retrospectively. Our data model describes measurements on four dimensions: the associated patient, observe... | 25,160,209 | [
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HTML5 microdata as a semantic container for medical information exchange. | Achieving interoperability between clinical electronic medical records (EMR) systems and cloud computing systems is challenging because of the lack of a universal reference method as a standard for information exchange with a secure connection. Here we describe an information exchange scheme using HTML5 microdata, wher... | 25,160,218 | [
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A novel SVM-ID3 hybrid feature selection method to build a disease model for melanoma using integrated genotyping and phenotype data from dbGaP. | The relations between Single Nucleotide Polymorphism (SNP) and complex diseases are likely to be non-linear and require analysis of the high dimensional data. Previous studies in the field mostly focus on genotyping and effects of various phenotypes are not considered. To fill this gap a hybrid feature selection model ... | 25,160,235 | [
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Comparing narrative versus numerical display of functional information: impact on sense-making. | Contextual information consists of functional, social, and financial information about patients. Physicians routinely have difficulty incorporating contextual information into clinical decision-making despite the emphasis on patient-centered care and functional status. One reason for this difficulty is that such inform... | 25,160,258 | [
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Assistive system for people with Apraxia using a Markov decision process. | CogWatch is an assistive system to re-train stroke survivors suffering from Apraxia or Action Disorganization Syndrome (AADS) to complete activities of daily living (ADLs). This paper describes the approach to real-time planning based on a Markov Decision Process (MDP), and demonstrates its ability to improve task's pe... | 25,160,274 | [
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A framework for privacy-preserving access to next-generation EHRs. | Although personalized medicine is optimizing the discovery, development and application of therapeutic advances, its full impact on patient and population healthcare management has yet to be realized. Electronic health Records (EHRs), integrated with data from other sources, such as social care data, Personal Healthcar... | 25,160,285 | [
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Determinants of eligibility and use of ehealth for cardiac rehabilitation patients: preliminary results. | To foster implementation of eHealth in care practice, it is important to gain insight into the factors that influence acceptance. The aim of this study was to identify determinants of eligibility and use for completing an electronic needs assessment for cardiac rehabilitation. We analysed the influence of age, gender, ... | 25,160,301 | [
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e-Literacy in health care. | This paper explores notions of e-Literacy (otherwise IT literacy or digital literacy) in health care. It proposes a multi-dimensional definition of e-Literacy in health care and provides suggestions for policy makers and managers as to how e-Literacy might be accounted for in their decisions. | 25,160,306 | [
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Heuristic evaluation and thinking aloud test of a digitized questionnaire for diabetes outpatient clinics. | Diabetes is a chronic disease characterized by hyperglycaemia. The number of patients with diabetes is expected to exceed 592 million in 2035. The growing number of diabetics is a great burden for the Danish healthcare system. The Danish government desires a modern and efficient healthcare system with a high patient se... | 25,160,322 | [
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Monitoring health IT integration--the effect of an EMR on laboratory service timeliness across six Australian hospitals. | The Electronic Medical Record (EMR) incorporates computerised provider order entry systems which allow clinicians to order diagnostic tests electronically, thus eliminating the need for cumbersome handwritten orders. In many situations the EMR relies on a manual transition of information across systems (e.g., integrati... | 25,160,329 | [
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Protocol feasibility workflow using an automated multi-country patient cohort system. | The Electronic Health Record for Clinical Research (EHR4CR) project aims to improve the current process of clinical trials, providing a technological platform that supports the design and execution of trials. For the protocol feasibility scenario, the system currently allows the user to create a set of in-/exclusion cr... | 25,160,335 | [
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A context-sensitive image annotation recommendation engine for radiology. | In the typical radiology reading workflow, a radiologist would go through an imaging study and annotate specific regions of interest. The radiologist has the option to select a suitable description (e.g., "calcification") from a list of predefined descriptions, or input the description directly as free-text. However, t... | 25,160,368 | [
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The influence of sex hormones on anterior cruciate ligament ruptures in males. | The purpose of this study is to determine the difference in the concentrations of testosterone, 17-β estradiol and progesterone between male patients with and without ACL rupture, as well as the possible effect of these hormones on generalized joint laxity. Male subjects with non-contact knee joint injury were included... | 25,160,472 | [
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Rebuilding self-confidence after cancer: a feasibility study of life-coaching. | Cancer survivors often experience decreased self-confidence which impacts negatively on their ability to self-manage the practical, social and emotional problems frequently faced as they emerge from end of treatment. This was a feasibility study of a life-coaching intervention, designed to rebuild confidence of survivo... | 25,160,492 | [
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Precision Marangoni-driven patterning. | A Marangoni flow is shown to occur when a polymer film possessing a spatially-defined surface energy pattern is heated above its glass transition to the liquid state. This can be harnessed to rapidly manufacture polymer films possessing prescribed height profiles. To quantify and verify this phenomenon, a model is desc... | 25,160,514 | [
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Advancing the application of systems thinking in health: understanding the growing complexity governing immunization services in Kerala, India. | Governing immunization services in a way that achieves and maintains desired population coverage levels is complex as it involves interactions of multiple actors and contexts. In one of the Indian states, Kerala, after routine immunization had reached high coverage in the late 1990s, it started to decline in some of th... | 25,160,531 | [
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Thiamine deficiency in infancy: long-term follow-up. | In 2003, several hundred Israeli infants risked thiamine deficiency after being fed a soy-based formula deficient in thiamine. Approximately 20 patients were seriously affected, and three of them died. We report the clinical presentation of acute encephalopathy in 11 children and the long-term sequelae of eight childre... | 25,160,536 | [
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White matter injury in newborns with congenital heart disease: a diffusion tensor imaging study. | Brain injury is observed on cranial magnetic resonance imaging preoperatively in up to 50% of newborns with congenital heart disease. Newer imaging techniques such as diffusion tensor imaging provide sensitive measures of the white matter integrity. The objective of this study was to evaluate the diffusion tensor imagi... | 25,160,542 | [
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Management of symptomatic cholelithiasis while on ketogenic diet: a case report. | The ketogenic diet is a treatment modality used for patients with refractory epilepsy. Development of cholelithiasis while on the ketogenic diet is a potential side effect that has been described in the literature. There however have not been any reports on the outcomes of continuing the diet after cholecystectomy. We ... | 25,160,551 | [
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A pediatric case of peripheral polyneuropathy with IgM anti-GM1 antibody associated with A group a beta-hemolytic Streptococcus infection. | Postinfectious peripheral neuropathy can be associated with various viral or bacterial infections. Group A beta-hemolytic Streptococcus infection can lead to neurological disorders, which involve predominantly the central nervous system, whereas peripheral neuropathy during childhood is rare. We describe a 12-year-old ... | 25,160,552 | [
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Reflections on mirror therapy: a systematic review of the effect of mirror visual feedback on the brain. | Mirror visual feedback (MVF), a phenomenon where movement of one limb is perceived as movement of the other limb, has the capacity to alleviate phantom limb pain or promote motor recovery of the upper limbs after stroke. The tool has received great interest from health professionals; however, a clear understanding of t... | 25,160,567 | [
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Amplified ambivalence: having a sibling with juvenile idiopathic arthritis. | Despite increased awareness of family responses to chronic illness and disability, there is still a need to understand experiences of well siblings. We begin to address this issue by asking, 'What is it like to have a sibling with juvenile idiopathic arthritis?' (JIA). Eight families with an adolescent diagnosed with J... | 25,160,580 | [
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Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. | In this study, we found that the full-length CYP2C8 (WT CYP2C8) and N-terminal truncated splice variant 3 (∼ 44-kDa mass) are localized in mitochondria in addition to the endoplasmic reticulum. Analysis of human livers showed that the mitochondrial levels of these two forms varied markedly. Molecular modeling based on ... | 25,160,618 | [
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The change in energy absorbed post removal of metalwork in a simulated paediatric long bone fracture. | The surgical treatment of paediatric fractures is increasing. Open reduction and internal fixation (ORIF) with plates and screws is long established, whilst the use of elastic stable intramedullary nailing (ESIN) has become increasingly popular. This study quantifies, in terms of the energy required to produce a fractu... | 25,160,647 | [
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Partial anomalous left pulmonary artery: report of two cases and review of literature. | We describe two cases of anomalous origin of the left lower-lobe pulmonary artery from the right pulmonary artery. The primary diagnosis was mitral atresia, hypoplastic left ventricle, aortic arch hypoplasia in the first child, and tetralogy of Fallot in the second. In both cases, the pulmonary trunk gave rise to a lef... | 25,160,653 | [
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Regioselective radical aminofluorination of styrenes. | The copper-catalyzed radical aminofluorination of styrenes with N-fluorobenzenesulfonimide (NFSI) is realized with high regioselectivity, thus affording aminofluorination products with regioselectivities opposite that of the palladium-catalyzed and noncatalyzed processes. Preliminary mechanistic studies suggested the r... | 25,160,663 | [
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Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells. | Members of Rho family GTPases including Cdc42 are known to play pivotal roles in cell migration. Cell migration is also known to be regulated by many protein kinases. Kinetworks KPSS 11.0 phospho-site screening of Cdc42-silenced Hs578T breast cancer cells revealed most dramatic change in ERK5 MAP kinase. In the present... | 25,160,664 | [
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The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases. | Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for the early prediction of renal diseases. NGAL may exist as monomer, dimer and/or NGAL/MMP-9 complex forms in humans. In this study, the existence of various forms of NGAL in urine (uNGAL) was determined and whether these forms are related to the... | 25,160,665 | [
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Averaging, not internal noise, limits the development of coherent motion processing. | The development of motion processing is a critical part of visual development, allowing children to interact with moving objects and navigate within a dynamic environment. However, global motion processing, which requires pooling motion information across space, develops late, reaching adult-like levels only by mid-to-... | 25,160,679 | [
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Presynaptic long-term depression mediated by Gi/o-coupled receptors. | Long-term depression (LTD) of the efficacy of synaptic transmission is now recognized as an important mechanism for the regulation of information storage and the control of actions, as well as for synapse, neuron, and circuit development. Studies of LTD mechanisms have focused mainly on postsynaptic AMPA-type glutamate... | 25,160,683 | [
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Long-term care of the heart transplant recipient. | This article will review the long-term care of the heart transplant recipient, focusing on the major causes of mortality and morbidity after transplantation. The major causes of mortality include rejection, infection, malignancy, and transplant coronary artery disease. The major causes of morbidity include renal dysfun... | 25,160,698 | [
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0.3539238,
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1H NMR global metabolic phenotyping of acute pancreatitis in the emergency unit. | We have investigated the urinary and plasma metabolic phenotype of acute pancreatitis (AP) patients presenting to the emergency room at a single center London teaching hospital with acute abdominal pain using (1)H NMR spectroscopy and multivariate modeling. Patients were allocated to either the AP (n = 15) or non-AP pa... | 25,160,714 | [
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Nanoscale three-dimensional imaging of the human myocyte. | The ventricular human myocyte is spatially organized for optimal ATP and Ca(2+) delivery to sarcomeric myosin and ionic pumps during every excitation-contraction cycle. Comprehension of three-dimensional geometry of the tightly packed ultrastructure has been derived from discontinuous two-dimensional images, but has ne... | 25,160,725 | [
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Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. | Haemodynamically significant patent ductus arteriosus is a significant cause of morbidity and mortality in pre-term infants. This retrospective study was conducted to investigate the usefulness of lower-dose paracetamol for the treatment of patent ductus arteriosus in pre-term infants. A total of 13 pre-term infants wh... | 25,160,728 | [
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Incidence and patterns of late recurrences in rectal cancer patients. | Long-term recurrences of rectal cancer raised questions about the possible benefit of prolonging the recommended active 5-year clinical and endoscopic surveillance. The aim of this study was to determine for the first time, incidence and patterns of late 10-year recurrence after curative resection of rectal cancer. The... | 25,160,733 | [
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Phosphodiesterase isoenzymes in the human urethra: a molecular biology and functional study. | Experimental and clinical studies have suggested a role for phosphodiesterase (PDE) isoenzymes in the control of the human lower urinary tract. This study aimed to investigate the expression of PDE isoenzymes and the effects of PDE inhibitors (PDE-Is) in isolated human urethral smooth muscle (USM). The expression of me... | 25,160,741 | [
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Immunogenicity and protective efficacy of recombinant M2e.Hsp70c (Hsp70(359-610)) fusion protein against influenza virus infection in mice. | New strategies in vaccine development are urgently needed to combat emerging influenza viruses and to reduce the risk of pandemic disease surfacing. Being conserved, the M2e protein, is a potential candidate for universal vaccine development against influenza A viruses. Mycobacterium tuberculosis Hsp70 (mHsp70) is know... | 25,160,757 | [
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Periodic rosuvastatin or atorvastatin dosing arrays (PRADA): patient-centered practice. | Non-adherence is a major obstacle with long-term daily statin therapy. This retrospective study reviewed the medical records of patients with hyperlipidemia during an 8-year period in a private internal medicine practice. Periodic dosing was negotiated following several patients' refusal of statin therapy because of mu... | 25,160,776 | [
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Ligand-mediated control of dislocation dynamics and resulting particle morphology of GdOCl nanocrystals. | While much progress has been achieved in the shape-controlled synthesis of nanocrystals, chemical strategies to define morphology remain primarily empirical. Here, a mechanistic study of the influence of different coordinating ligands on the kinetics and thermodynamics of crystal growth during the preparation of GdOCl ... | 25,160,777 | [
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G-CSF displays restricted ability to promote Sca-1(+) cardiac stem cell proliferation in vitro. | Granulocyte colony-stimulating factor (G-CSF) is a controversial chemical in cardiac cell therapy. Myocardial homing of mobilized bone marrow-derived cells is thought to play a critical role in observed G-CSF-induced cardiac repair; meanwhile, the activation of proliferative potential of cardiac stem cells (CSCs) resid... | 25,160,782 | [
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'They had the right to know.' Genetic risk and perceptions of responsibility. | The idea that people should be responsible for their health is not new. The construction of health as a moral issue has often been applied to voluntary health risks. With the advent of predictive genetic testing, however, people may also bear responsibility for their genetic risks. Drawing upon 24 semi-structured inter... | 25,160,812 | [
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[Relevance of magnetic resonance imaging for catheter ablation of atrial fibrillation]. | Currently, atrial fibrillation is the most common form of arrhythmia encountered in clinical practice. Until recently the treatment approach to atrial fibrillation was limited by imprecise risk stratification models and suboptimal therapy options. At present cardiac magnetic resonance imaging (MRI) is an important noni... | 25,160,815 | [
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Comparative trends in the incidence of hospitalized myocardial infarction and coronary heart disease in adults with and without diabetes mellitus in Western Australia from 1998 to 2010. | The risk of myocardial infarction (MI) is elevated in people with diabetes mellitus (DM) compared with non-DM counterparts. The aim of this study was to compare population trends in the incidence of hospitalized MI and coronary heart disease (CHD) in adults with and without DM. All incident hospitalized MI and CHD even... | 25,160,842 | [
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Endoscopic lateral orbitotomy. | Lateral orbitotomy can be minimalized using contemporary endoscopy. Anatomy of the temporal fossa/orbital wall junction is described. The attachment of the temporal fascia is cut off from the orbital rim through a 1.5 cm skin incision in the lateral orbital wrinkle. The temporal muscle is detached from the bone to crea... | 25,160,850 | [
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Peripheral nerve stimulation by 'sandwich' paddle leads: technical note. | Recently, there has been a burgeoning interest in the utility of peripheral nerve stimulation (PNS) for a variety of chronic focal neuropathic, musculoskeletal and visceral pain conditions. If the source of pain is directly related to a single peripheral nerve, surgical exposure and placing a paddle lead on the nerve a... | 25,160,853 | [
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Immunoglobulin G4 related disease isolated to the nasal cavity: a rare cause of nasal obstruction. | Immunoglobulin G4 related disease is a rare condition. Cases involving the sinonasal region are exceptionally uncommon. This paper describes a case of immunoglobulin G4 related disease isolated solely to the nasal cavity. Case report and literature review. A 34-year-old man presented with painless, progressive bilatera... | 25,160,869 | [
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Just world beliefs, perceived stress, and health behavior: The impact of a procedurally just world. | Recent research suggests that a just world view may promote good health while low belief in a just world may deleteriously affect well-being. However, this research is limited in that specific components of justice beliefs that are important to health are not well articulated. Additionally, many potential pathways link... | 25,160,884 | [
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Prevalence and correlates of knowledge of male partner HIV testing and serostatus among African-American women living in high poverty, high HIV prevalence communities (HPTN 064). | Knowledge of sexual partners' HIV infection can reduce risky sexual behaviors. Yet, there are no published studies to-date examining prevalence and characteristics associated with knowledge among African-American women living in high poverty communities disproportionately affected by HIV. Using the HIV Prevention Trial... | 25,160,901 | [
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Phylogeography of Cephalotaxus oliveri (Cephalotaxaceae) in relation to habitat heterogeneity, physical barriers and the uplift of the Yungui Plateau. | Habitat heterogeneity, physical barriers, and the uplift of the Yungui Plateau were found to deeply affect the phylogeographic pattern and evolutionary history of Cephalotaxus oliveri, a perennial conifer endemic to China. In this study, we explored the phylogeography using three chloroplast sequences (trnL-trnF, trnT-... | 25,160,902 | [
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Social support and cardiovascular responding to laboratory stress: moderating effects of gender role identification, sex, and type of support. | The objective of the present study was to examine moderating effects of gender role identification, sex, and type of support on the buffering role of social support on cardiovascular responses. We hypothesized that (a) gender role identification, more than sex, would moderate the effect of social support and (b) to obt... | 25,160,919 | [
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Mitochondrial respiration and genomic analysis provide insight into the influence of the symbiotic bacterium on host trypanosomatid oxygen consumption. | Certain trypanosomatids co-evolve with an endosymbiotic bacterium in a mutualistic relationship that is characterized by intense metabolic exchanges. Symbionts were able to respire for up to 4 h after isolation from Angomonas deanei. FCCP (carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone) similarly increased respir... | 25,160,925 | [
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The benefits of being bilingual: working memory in bilingual Turkish-Dutch children. | Whether bilingual children outperform monolingual children on visuospatial and verbal working memory tests was investigated. In addition, relations among bilingual proficiency, language use at home, and working memory were explored. The bilingual Turkish-Dutch children (n=68) in this study were raised in families with ... | 25,160,938 | [
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Chronic inhibition of brain phospholipase A2 in adult rats impairs the survival of newborn mature neurons in the hippocampus. | Adult neurogenesis occurs in the hippocampal dentate gyrus (DG) and lateral ventricles, and includes cell proliferation and neuronal differentiation, maturation and survival. In vitro studies suggest a role for phospholipase A2 (PLA2) in neuronal differentiation/maturation and survival. This study aimed to investigate ... | 25,160,937 | [
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The identification and quantification of a high molecular weight light stabilizer in polycarbonate by application of an online coupling of size exclusion chromatography in stopped flow mode with pyrolysis gas chromatography time of flight mass spectroscopy. | The identification and quantification of a high molecular weight light stabilizer (Uvinul 3030™) in an unknown polycarbonate sample was achieved through the application of SEC-Py-TOF-GCMS. A size exclusion column optimized to achieve resolution in the lower mass range was applied to allow the fractionation of an indivi... | 25,160,954 | [
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Establishing institutional ethics committees: challenges and solutions - a review of the literature. | This review of the literature was conducted to identify the challenges faced while establishing institutional ethics committees (IECs) as well as to suggest some solutions. The search of the literature was carried out with the help of the PubMed search engine, using “research ethics committees” (MeSH] and “India” (MeSH... | 25,160,969 | [
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Development of T. aestivum L.-H. californicum alien chromosome lines and assignment of homoeologous groups of Hordeum californicum chromosomes. | Hordeum californicum (2n = 2x = 14, HH) is resistant to several wheat diseases and tolerant to lower nitrogen. In this study, a molecular karyotype of H. californicum chromosomes in the Triticum aestivum L. cv. Chinese Spring (CS)-H. californicum amphidiploid (2n = 6x = 56, AABBDDHH) was established. By genomic in situ... | 25,160,976 | [
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An individual patient data meta-analysis on characteristics, treatments and outcomes of the glioblastoma/gliosarcoma patients with central nervous system metastases reported in literature until 2013. | Dissemination of high-grade gliomas (WHO IV) has been investigated poorly so far. We conducted an extensive analysis of the characteristics, treatments and outcomes of the glioblastoma multiforme (GBM)/gliosarcoma (GS) patients with central nervous system (CNS) metastases reported in literature until April 2013. PubMed... | 25,160,993 | [
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Filter lifespan in critically ill adults receiving continuous renal replacement therapy: the effect of patient and treatment-related variables. | To examine the effects of patient and treatment-related variables on filter lifespan in critically ill adults receiving continuous renal replacement therapy (CRRT). This was a single-centre, retrospective, observational study conducted in a tertiary referral centre in metropolitan Melbourne, Australia. All CRRT filters... | 25,161,027 | [
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Essential role of the N- and C-terminals of laccase from Pleurotus florida on the laccase activity and stability. | POXA1b is the most thermostable laccase isoenzyme from Pleurotus ostreatus. POXA1b is remarkably stable at alkaline pH (the t1/2 at pH 10 was 30 days), and its C-terminal affects its catalytic and stability properties. We cloned POXA1c from P. florida, which showed 99 % identity with POXA1b. POXA1c was functionally exp... | 25,161,036 | [
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Is problematic internet use an indicator of eating disorders among Turkish university students? | The aim of this study was to investigate the relationship between problematic internet use and eating attitudes in a group of university students. The study sample consisted of 314 students attending programs at the faculties of education, medicine and communications at the Karadeniz Technical University in Turkey. One... | 25,161,050 | [
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Prevention of childhood malnutrition: immensity of the challenge and variety of strategies. | The scope of this review is partly dictated by the global concern to improve nutrition, starting with proclamation of the Millennium Development Goals, followed by the Scaling-up Nutrition (SUN) project. The global and regional prevalence of child malnutrition is described and discussed in detail. The various and somet... | 25,161,059 | [
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Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions. | Mast cells (MCs) are important effector cells in asthma and pulmonary inflammation, and their proliferation and maturation is maintained by stem cell factor (SCF) via its receptor, c-Kit. Cysteinyl leukotrienes (cys-LTs) are potent inflammatory mediators that signal through CysLT1 R and CysLT2 R located on the MC surfa... | 25,161,061 | [
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Analysis of the yeast short-term Crabtree effect and its origin. | The short-term Crabtree effect is defined as the immediate occurrence of aerobic alcoholic fermentation in response to provision of a pulse of excess sugar to sugar-limited yeast cultures. Here we have characterized ten yeast species with a clearly defined phylogenetic relationship. Yeast species were cultivated under ... | 25,161,062 | [
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Pooled analysis of tiotropium Respimat(®) pharmacokinetics in cystic fibrosis. | Tiotropium is the first bronchodilator to be studied systematically in cystic fibrosis (CF). We investigated whether any intrinsic or extrinsic factors affected pharmacokinetic (PK) parameters of inhaled tiotropium delivered by Respimat(®) in adults and children with CF. Tiotropium PK in patients with CF was compared w... | 25,161,072 | [
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Toll like receptors: a new hope on the horizon to treat multiple sclerosis. | Evolving data have shown that the toll like receptors (TLRs) family of innate immune receptors has an important role in driving the activation and inhibition of pathogenic pathways involved in multiple sclerosis (MS). While developing clinical trials targeting MS by TLRs modulators are of considerable interest, several... | 25,161,080 | [
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Sub-chronic agmatine treatment modulates hippocampal neuroplasticity and cell survival signaling pathways in mice. | Agmatine is an endogenous neuromodulator which, based on animal and human studies, is a putative novel antidepressant drug. In this study, we investigated the ability of sub-chronic (21 days) p.o. agmatine administration to produce an antidepressant-like effect in the tail suspension test and examined the hippocampal c... | 25,161,097 | [
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Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes. | To evaluate the risk of urinary tract infections (UTI) in subjects with newly diagnosed type 2 diabetes mellitus (T2DM). Subjects aged ≥18years and diagnosed with T2DM between 1/1/10 and 12/31/10 were identified using the MarketScan® databases, which are representative of the commercially insured US population and thos... | 25,161,100 | [
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Renal biopsy in patients over 75: 131 cases. | Demographic analysis shows the ageing of the global population and the consequent increase in the age of hospitalized subjects and of patients starting dialysis. Hence, interest in the feasibility, safety, and usefulness of renal biopsy in elderly patients is growing. We examined the data of 131 patients over the age o... | 25,161,113 | [
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Mild hyponatremia is associated with functional and cognitive decline in chronic hemodialysis patients. | A high incidence and adverse outcomes of cognitive impairment in dialysis patients have recently become recognized. Classical risk factors, uremia, anemia, metabolic disturbances, and hemodynamic instability during dialysis accelerate vascular cognitive impairment. To evaluate laboratory factors that influence cognitiv... | 25,161,116 | [
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Adipose stem cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity via the IGF-1/PI3K/AKT pathway. | Previous studies suggest that the delivery of neurotrophic factors secreted from adipose stromal cells (ASC) protect the brain from 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. However, it remains unclear which secreted neurotrophic factor has an important role in protecting 6-OHDA-treated neurons. Through the use... | 25,161,124 | [
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Performance of the European System for Cardiac Operative Risk Evaluation II: a meta-analysis of 22 studies involving 145,592 cardiac surgery procedures. | A systematic review of the European System for Cardiac Operative Risk Evaluation (euroSCORE) II performance for prediction of operative mortality after cardiac surgery has not been performed. We conducted a meta-analysis of studies based on the predictive accuracy of the euroSCORE II. We searched the Embase and PubMed ... | 25,161,130 | [
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Quality improvement project: implementing guidelines supporting noninvasive respiratory management for premature infants. | Based on research evidence, the purpose was to implement noninvasive approaches in the initial respiratory stabilization of preterm infants. Quality improvement project. One hundred fourteen infants admitted to the neonatal intensive care nursery (NICN) from January 1, 2012 to May 31, 2012 served as a historical contro... | 25,161,132 | [
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Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis. | Tumor necrosis factor superfamily 15 (TNFSF15) suppresses angiogenesis by specifically inducing apoptosis in proliferating endothelial cells. Death receptor 3 (DR3), a member of the TNF receptor superfamily (TNFRSF25), has been identified as a receptor for TNFSF15 to activate T cells. It is unclear, however, whether DR... | 25,161,149 | [
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Alteration of neural action potential patterns by axonal stimulation: the importance of stimulus location. | Stimulation of peripheral nerves is often superimposed on ongoing motor and sensory activity in the same axons, without a quantitative model of the net action potential train at the axon endpoint. We develop a model of action potential patterns elicited by superimposing constant frequency axonal stimulation on the acti... | 25,161,163 | [
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Efavirenz induces neuronal autophagy and mitochondrial alterations. | Efavirenz (EFV) is a non-nucleoside reverse-transcriptase inhibitor in wide use for the treatment of human immunodeficiency virus infection. Although EFV is generally well tolerated, neuropsychiatric toxicity has been well documented. The toxic effects of EFV in hepatocytes and keratinocytes have been linked to mitocho... | 25,161,171 | [
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Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy. | During radiotherapy for gastric lymphoma, it is difficult to protect the liver and kidneys in cases where there is considerable overlap between these organs and the target volume. This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy (3DCRT), half-field ... | 25,161,174 | [
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Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. | A subgroup of the cholesterol-dependent cytolysin (CDC) family of pore-forming toxins (PFTs) has an unusually narrow host range due to a requirement for binding to human CD59 (hCD59), a glycosylphosphatidylinositol (GPI)-linked complement regulatory molecule. hCD59-specific CDCs are produced by several organisms that i... | 25,161,188 | [
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What is the effect of unemployment on all-cause mortality? A cohort study using propensity score matching. | There is a strong association between unemployment and mortality, but whether this relationship is causal remains debated. This study utilizes population-level administrative data from Scotland within a propensity score framework to explore whether the association between unemployment and mortality may be causal. The s... | 25,161,201 | [
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Broad-Enrich: functional interpretation of large sets of broad genomic regions. | Functional enrichment testing facilitates the interpretation of Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) data in terms of pathways and other biological contexts. Previous methods developed and used to test for key gene sets affected in ChIP-seq experiments treat peaks as points, a... | 25,161,225 | [
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Polytomy refinement for the correction of dubious duplications in gene trees. | Large-scale methods for inferring gene trees are error-prone. Correcting gene trees for weakly supported features often results in non-binary trees, i.e. trees with polytomies, thus raising the natural question of refining such polytomies into binary trees. A feature pointing toward potential errors in gene trees are d... | 25,161,242 | [
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0.1318213,
0.1177078,
-0.129924,
-0.... |
ASTRAL: genome-scale coalescent-based species tree estimation. | Species trees provide insight into basic biology, including the mechanisms of evolution and how it modifies biomolecular function and structure, biodiversity and co-evolution between genes and species. Yet, gene trees often differ from species trees, creating challenges to species tree estimation. One of the most frequ... | 25,161,245 | [
0.2417041,
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0.1942796,
0.02321372,
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0.1409459,
-0.383793,
-0.1462457,
0.07214874,
0.1267817,
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0.06994905,
0.009904074,
-0.111179,
0.03640408,
0.1397862,
0.1356128,
0.1019751,
-0.2193588,
-0.28... |
Unveiling new biological relationships using shared hits of chemical screening assay pairs. | Although the integration and analysis of the activity of small molecules across multiple chemical screens is a common approach to determine the specificity and toxicity of hits, the suitability of these approaches to reveal novel biological information is less explored. Here, we test the hypothesis that assays sharing ... | 25,161,250 | [
-0.1216376,
0.1780231,
0.1948286,
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0.2857418,
0.1533932,
0.2352786,
0.1011803,
0.2510098,
-0.2139029,
-0.156... |
Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression. | Packaging specific exogenous active proteins and DNAs together within a single viral-nanocontainer is challenging. The bacteriophage T4 capsid (100 × 70 nm) is well suited for this purpose, because it can hold a single long DNA or multiple short pieces of DNA up to 170 kb packed together with more than 1,000 protein mo... | 25,161,284 | [
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0.07638592,
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0.006035575,
0.05575789,
0.1911398,
0.1179292,
-0.1522473,
... |
Double lumen endotracheal tube for percutaneous tracheostomy. | Percutaneous dilational tracheostomy is normally a bronchoscope-guided procedure. The insertion of a bronchoscope into an endotracheal tube (ETT) affects resistance, flow, and alveolar pressure. To improve airway management and ventilation during percutaneous tracheostomy, we developed a double lumen endotracheal tube ... | 25,161,301 | [
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0.1731572,
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0.03301419,
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0.01885844,
-0.... |
An innovative childhood asthma score predicts the need for bronchodilator nebulization in children with acute asthma independent of auscultative findings. | We sought to compare the accuracy of a newly developed childhood asthma score (CAS) with routine clinical assessment of respiratory status in children with acute asthma in predicting requirements for bronchodilator nebulization. In this prospective observational study in children 2-18 y old with acute asthma, we evalua... | 25,161,304 | [
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-0.200295,... |
The In vitro anti-acne activity of two unani drugs. | Acne is the most common disorder treated by dermatologists. As many as 80-90% of all adolescents have some type of acne and 30% of them require medical treatment. It is an inflammatory disease of the pilosebaceous unit characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. T... | 25,161,328 | [
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0.4781961,
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0.01060249,
0.03239184,
-0.06193517,
0... |
Molluscum contagiosum: A novel Ayurvedic approach. | Three cases of molluscum contagiosum (MC) approached our outpatient Department of Dermatology complaining of umbilicated, skin-colored, firm, painless papules over the neck and face. All of them were immune competent. The medical, social, and family history was insignificant. The lesions were, numerous and recurrent. H... | 25,161,331 | [
0.02893061,
0.05056794,
0.03678469,
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0.03159548,
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-0.2639697,
-0.0600279,
0.410473,
0.3760243,
-0.2491333,
0... |
Incompatible blood transfusion: Challenging yet lifesaving in the management of acute severe autoimmune hemolytic anemia. | Autoimmune hemolytic anemia (AIHA) is characterized by the production of autoantibodies directed against red cell antigens. Most patients of AIHA arrive in the emergency or out-patient department (OPD) with severe anemia requiring urgent blood transfusion. Here we share our experience of managing these patients with in... | 25,161,349 | [
-0.2274874,
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0.2454071,
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0.6824817,
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-0.4509591,
-0.2636631,
0.03220668,
-0.2134966,
-0.0005981193,
0.07252557,
-0.15... |
Acute lung injury after platelet transfusion in a patient with dengue fever. | Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasmacontaining blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related mortality. This complication typically presents as shortness of breath, hypoxemia, hypo... | 25,161,356 | [
-0.1443476,
0.2263326,
-0.0161205,
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-0.06580972,
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0.05842273,
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-0.08407906,
0.04094383,
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0.1381559,
0.05267574,
0.06703029,
-0.01623531,
-0.1200467,
0.06228542,
-0.181... |
Design and Application of a Novel Virtual Reality Navigational Technology (VRNChair). | This paper presents a novel virtual reality navigation (VRN) input device, called the VRNChair, offering an intuitive and natural way to interact with virtual reality (VR) environments. Traditionally, VR navigation tests are performed using stationary input devices such as keyboards or joysticks. However, in case of im... | 25,161,366 | [
-0.3176697,
-0.2916848,
0.2523496,
0.1624414,
0.2559296,
-0.3152857,
-0.1690185,
-0.08539994,
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0.04224332,
-0.07417774,
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-0.1266037,
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-0.3403813,
-0.4980149,
0.3099607,
-0.5987894,
-0.4483497,
-0.3208518,
0.09963512,
-0.0440725... |
An overview on in situ micronization technique - An emerging novel concept in advanced drug delivery. | The use of drug powders containing micronized drug particles has been increasing in several pharmaceutical dosage forms to overcome the dissolution and bioavailability problems. Most of the newly developed drugs are poorly water soluble which limits dissolution rate and bioavailability. The dissolution rate can be enha... | 25,161,371 | [
-0.2918721,
0.08348381,
0.3509981,
-0.1034853,
0.009217967,
-0.1239821,
-0.1959774,
0.01150519,
0.03083001,
-0.09128428,
0.1593962,
-0.4171669,
0.01649573,
0.1097108,
-0.4311212,
-0.1737816,
-0.05776742,
-0.2071336,
-0.01405393,
-0.1194749,
0.2476239,
-0.1233469,
-0.09767... |
Do insulin cartridges really provide a lower risk of potential diabetes complications than traditional vials? | Recently, many publicly funded healthcare organizations suffered from an economical crisis. This forced some organizations to utilize less costly alternatives where possible. Insulin cartridges and vials are examples. Many patients are questioning the difference between the two alternatives as they contain the same act... | 25,161,382 | [
-0.3513409,
0.1456237,
-0.2049875,
0.02681571,
0.03543885,
-0.03281832,
-0.2755379,
0.239386,
0.3001566,
0.1759778,
0.156115,
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-0.169526,
0.003160281,
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0.06771155,
-0.005471794,
0.0288697,
0.3313918,
0.3386774,
0.1150138,
0.1198841,
-0... |
Implementation of Steiner point of fuzzy set. | This paper deals with the implementation of Steiner point of fuzzy set. Some definitions and properties of Steiner point are investigated and extended to fuzzy set. This paper focuses on establishing efficient methods to compute Steiner point of fuzzy set. Two strategies of computing Steiner point of fuzzy set are prop... | 25,161,396 | [
0.0003989234,
0.1463764,
-0.01118151,
-0.1747823,
0.1228082,
-0.09799794,
-0.4852737,
0.02513234,
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-0.01475563,
-0.09710602,
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0.03713539,
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-0.2174123,
-0.1433432,
-0.1275248,
0.04108803,
-0.07504201,
-0.1060361,
-0.1591... |
Multichannel broadcast based on home channel for cognitive radio sensor networks. | Considering the limited resources and the dynamic spectrum distribution in the cognitive radio sensor networks (CRSN), a half-duplex Multichannel broadcast protocol for CRSN is presented based on the home channel. This protocol maintains the networks topology only through the home channel, so there is no need for the p... | 25,161,397 | [
-0.03940962,
0.3106966,
0.02002641,
-0.0199577,
0.05782019,
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-0.6995975,
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0.02500331,
-0.003291534,
-0.1040917,
0.1098508,
0.3327344,
0.139665,
... |
Pre-hospital management of febrile seizures in children seen at the university college hospital, ibadan, Nigeria. | Febrile seizures are commonly encountered in emergency paediatric practice. Initial pre-hospital intervention given by caregivers has been shown to impact outcome. To describe the spectrum of pre-hospital interventions given for the treatment of childhood febrile seizures in Ibadan, Nigeria. All consecutive cases of fe... | 25,161,406 | [
0.02762251,
0.007350809,
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-0.01553048,
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0.05573475,
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0.3336815,
0.108959,
0.110876,
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... |
Right ampullary ectopic pregnancy following bilateral tubal ligation using spring clips. | Pregnancy is unlikely to occur in women who have undergone sterilization. However when it occurs, there is a substantial risk that it will be an ectopic pregnancy. We report a case of right unruptured ampullary ectopic gestation following tubal sterilization with spring clips 6 years prior to presentation. The likely a... | 25,161,421 | [
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0.09558053,
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0.01912616,
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-0.06706128,
-0.4397019,
-0.7527709,
0.01721848,
0.1729065,
-0.140449... |
Maxillary first premolar with three root canals: a case report. | The maxillary first premolar is the most commonly bi- rooted tooth with occasional presentation of three roots system; it is a transitional tooth between incisors and molars. Although it usually has two canals, it may rarely have three and this third canal can easily be missed. Thus meticulous knowledge of tooth morpho... | 25,161,429 | [
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0.3458441,
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0.003632596,
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0.1924032,
-0.5274961,
-0.4381327,
0.190468,
0.2454869,
0.148208,
... |
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