title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability. | Cerebrovascular events contribute to ~40% of preeclampsia/eclampsia-related deaths, and neurological symptoms are common among preeclamptic patients. We previously reported that placental ischemia, induced by reducing utero-placental perfusion pressure, leads to impaired myogenic reactivity and cerebral edema in the pr... | 25,168,877 | [
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Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers. | Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treated... | 25,168,880 | [
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Determinants of height and biological inequality in Mediterranean Spain, 1859-1967. | This article analyses not only the determinants of the height of Spain's male populations between 1859 and 1960 but also the influence that social inequality had upon biological well-being. The height data of 82,039 conscripts constitute the principal source for this analysis. The study area comprises the current Valen... | 25,168,885 | [
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SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator. | Our previous study revealed the immunomodulatory property of the secreted lymphocyte antigen (Ly6)/urokinase-type plasminogen activator receptor (uPAR)-related protein-1 (SLURP1), abundantly expressed in the cornea and associated with the hyperkeratotic disorder Mal de Meleda. Here, we test the hypothesis that SLURP1 m... | 25,168,896 | [
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Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs. | The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has be... | 25,168,906 | [
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Imaging of site specific bone turnover in osteoporosis using positron emission tomography. | The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ((18)F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. (18)F-NaF PET provides a novel and noninvasive met... | 25,168,931 | [
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Treatment of intracerebral hemorrhage associated with new oral anticoagulant use: the neurologist's view. | Intracerebral hemorrhage (ICH) associated with the use of oral anticoagulants (OAC-ICH) results in particularly severe strokes. A key target for the treatment of OAC-ICH is rapid restoration of effective coagulation. In patients receiving vitamin K antagonists, hemostatic factors such as prothrombin complex concentrate... | 25,168,944 | [
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Serum Endocan Level and the Severity of Coronary Artery Disease: A Pilot Study. | Endothelial-specific molecule 1 (endocan) is expressed in endothelial cells. We investigated the relationship between acute coronary syndrome (ACS) and serum endocan levels. We included 30 individuals as a control group and 53 patients diagnosed with ACS. The severity of coronary artery disease was assessed by a modifi... | 25,168,956 | [
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In vitro antifungal susceptibility of Malassezia furfur from bloodstream infections. | Fungaemia caused by Malassezia spp. in hospitalized patients requires prompt and appropriate therapy, but standard methods for the definition of the in vitro antifungal susceptibility have not been established yet. In this study, the in vitro susceptibility of Malassezia furfur from bloodstream infections (BSIs) to amp... | 25,168,965 | [
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Across-shift changes of exhaled nitric oxide and spirometric indices among cotton textile workers. | For the purpose of evaluation of exhaled NO as an index of airway inflammation, we assessed changes in fractional exhaled NO (FeNO) across a work shift and its relationship with respiratory complaints. Chronic and work-aggravated respiratory complaints were assessed using a questionnaire in 89 male textile workers. FeN... | 25,168,972 | [
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Investigation of the relationship between illogical thoughts and dependence on others and marriage compatibility in the Iranian Veterans exposed to chemicals in Iran-Iraq War. | Marital satisfaction is one of the main determinants of a family's correct function. A large number of veterans have been reported to suffer from depression, anxiety, mood disorders, post-traumatic stress disorder, and physical disorders. The objective of this study is to examine association between Illogical thoughts ... | 25,168,982 | [
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Design and evaluation of electronic briefs of neonatal intensive care unit in Taleghani hospital, Tabriz, Iran. | More than 9 million neonatal deaths are reported through out the world each year happening in the early weeks of life most of which relate to developing countries. Thus it is very important to present a better way to keep the infants healthy which could be possible by accessing accurate information at any time required... | 25,168,989 | [
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Assessment of patient satisfaction of the quality of health care provided by outpatient services of an oncology hospital. | The purpose of this research is to investigate the patient's satisfaction (patient's satisfaction) with medical services provided in Outpatients' Departments of a Greek Anti-Cancer Hospital in morning and afternoon clinics. The assessment of patients and identification of factors that contribute to their satisfaction w... | 25,169,006 | [
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Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways. | Triptolide (TP), a major active ingredient extracted from the widely used Chinese herb Tripterygium wilfordii Hook f. (TWHF), has been demonstrated to possess various biological activities. However, the clinical applications of TP are limited by its narrow therapeutic window and severe toxicity. The current study aimed... | 25,169,008 | [
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Intrinsic religiousness and well-being among cancer patients: the mediating role of control-related religious coping and self-efficacy for coping with cancer. | We examined the relationship between intrinsic religiousness and well-being, with control-related religious coping and self-efficacy for coping with cancer as potential mediators of this relationship among cancer patients. In a cross-sectional design, 179 ambulatory cancer patients completed measures of intrinsic relig... | 25,169,026 | [
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Modified cranialization and secondary cranioplasty for frontal sinus infection after craniotomy: technical note. | Frontal sinus infection after incorrect treatment of an opened frontal sinus may require extended approaches. This article aims to introduce modified cranialization technique and secondary cranioplasty for frontal sinus infection involving the frontal sinus outflow tract after craniotomy. Eight patients with delayed on... | 25,169,030 | [
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Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype. | Lipidomics reveals a remarkable diversity of lipids in human plasma. In this study, we have performed an in-depth lipidomic analysis of human plasma from healthy individuals and subjects with metabolic syndrome (MetS) in order to determine the lipidomic profile that allows prognosis of a pathological subpopulation with... | 25,169,057 | [
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WIP is necessary for matrix invasion by breast cancer cells. | Actin filament assembly and reorganisation during cell migration and invasion into extracellular matrices is a well-documented phenomenon. Among actin-binding proteins regulating its polymerisation, the members of the WASP (Wiskott Aldrich Syndrome Protein) family are generally thought to play the most significant role... | 25,169,059 | [
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Changes in the perfusion waveform of the internal cerebral vein and intraventricular hemorrhage in the acute management of extremely low-birth-weight infants. | This prospective observational study aimed to investigate the association between changes in the Doppler perfusion waveform of the internal cerebral vein and risk of intraventricular hemorrhage (IVH) in extremely low-birth-weight (ELBW) infants. We evaluated the perfusion waveform of the internal cerebral vein every 8 ... | 25,169,064 | [
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[Levels of complement components C3a and C5a in renal injury among trichloroethylene-sensitized BALB/c mice]. | To determine the levels of complement components C3a and C5a in the kidneys of trichloroethylene (TCE)-sensitized BALB/c mice, and to investigate the role of complement components in TCE-induced renal injury among BALB/c mice. Sixty-two female BALB/c mice were randomly divided into blank control group, vehicle control ... | 25,169,086 | [
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[Preventive effects of garlic oil against the benzene-induced hematotoxicity in mice]. | To investigate the preventive effects of garlic oil (GO) on benzene-induced hematotoxicity in mice. Specific pathogen-free male Kunming mice were randomly divided into 5 groups, i.e., control group, model group, and low-, middle-, and high-dose GO groups (n = 20 in each group). Mice in GO groups were orally given GO at... | 25,169,096 | [
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Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes. | Leukotoxin (LtxA; Leukothera), a protein toxin secreted by the oral bacterium Aggregatibacter actinomycetemcomitans, specifically kills white blood cells (WBCs). LtxA binds to the receptor known as lymphocyte function associated antigen-1 (LFA-1), a β2 integrin expressed only on the surface of WBCs. LtxA is being studi... | 25,169,107 | [
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Physiologic comparison of neurally adjusted ventilator assist, proportional assist and pressure support ventilation in critically ill patients. | To compare, in a group of difficult to wean critically ill patients, the short-term effects of neurally adjusted ventilator assist (NAVA), proportional assist (PAV+) and pressure support (PSV) ventilation on patient-ventilator interaction. Seventeen patients were studied during NAVA, PAV+ and PSV with and without artif... | 25,169,117 | [
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A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival. | GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR). It has been reported that GPCRs play vital roles in the development and progression of cancer. To investigate the potential roles of GPR37 in hepatocellular carcinoma (HCC), expression of GPR37 was ... | 25,169,131 | [
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Nuclear model analysis of excitation functions of proton and deuteron induced reactions on (64)Zn and (3)He- and α-particle induced reactions on (59)Co leading to the formation of copper-61: Comparison of major production routes. | Cross section data for formation of the medically important radionuclide (61)Cu (T½=3.33h) in proton and deuteron induced reactions on enriched (64)Zn and in (3)He- and α-particle induced reactions on (59)Co were analyzed by using the nuclear model calculational codes, EMPIRE and TALYS. A well-defined statistical proce... | 25,169,133 | [
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Disparate plasma cortisol concentrations in sexually abused female children from Johannesburg, South Africa. | A growing body of research indicates that a bidirectional response to a stressor may occur in maltreated children and may be associated with later life psychopathology. However, few studies have investigated stress reactivity in children when they first present to a sexual abuse clinic. Thus, in order to evaluate wheth... | 25,169,148 | [
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SWI/SNF chromatin remodeling complexes and cancer. | The identification of mutations and deletions in the SMARCB1 locus in chromosome band 22q11.2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the SWI/SNF chromatin remodeling complex in cancer. Over the last 15 years, alterations in more than 20 members of the complex have been reported ... | 25,169,151 | [
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... |
Middle school student attitudes about school drinking fountains and water intake. | To describe middle school student attitudes about school drinking fountains, investigate whether such attitudes are associated with intentions to drink water at school, and determine how intentions relate to overall water intake. Students (n = 3211) in 9 California middle schools completed surveys between 2009 and 2011... | 25,169,158 | [
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Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. | Recent studies showed that lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular disease (CVD). However, whether Lp(a) modifies clinical risk assessment was not established. This study was conducted to determine whether Lp(a) improves CVD risk prediction. In 1995, Lp(a) was measured in 826 men and women (ag... | 25,169,167 | [
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Programmed cell death of retinal cone bipolar cells is independent of afferent or target control. | Programmed cell death contributes to the histogenesis of the nervous system, and is believed to be modulated through the sustaining effects of afferents and targets during the period of synaptogenesis. Cone bipolar cells undergo programmed cell death during development, and we confirm that the numbers of three differen... | 25,169,191 | [
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Transient substrate-induced catalyst formation in a dynamic molecular network. | In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms are underdeveloped. We now report how a substrate of a chemical reaction induces the formation of its own catalyst from a dynamic molecular network. After complete conversion of the substrate, the... | 25,169,198 | [
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Effectiveness of the population-based Check your health preventive programme conducted in primary care with 4 years follow-up [the CORE trial]: study protocol for a randomised controlled trial. | The periodic health check-up has been a fundamental part of routine medical practice for decades, despite a lack of consensus regarding its value in health promotion and disease prevention. A large-scale Danish population-based preventive programme 'Check your health' was developed based on available evidence of screen... | 25,169,211 | [
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[Health status analysis of Guangzhou traffic police officers in 2013]. | To analyze the health examination results of Guangzhou traffic police officers in 2013, and to investigate their health status and provide a scientific basis for the health management of traffic police officers. The physical examination data of the Guangzhou traffic police officers in 2013 were analyzed. The data were ... | 25,169,223 | [
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[Risk assessment and risk control for occupational exposure to chemical toxicants from an isophorone nitrile device]. | Risk assessment and risk control for occupational exposure to chemical toxicants were performed on an isophorone nitrile device with an annual production of 5,000 tons, based on improved Singaporean semi-quantitative risk assessment method, with consideration of actual situation in China and in the present project. Wit... | 25,169,239 | [
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Dexmedetomidine in the treatment of serotonin syndrome. | Patients suffering from moderate to severe serotonin syndrome frequently present with autonomic instability and altered mental status. Management of serotonin syndrome can be complex and may be refractory to treatment with benzodiazepines alone. The objective of this series is to present 3 cases of serotonin syndrome t... | 25,169,248 | [
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Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs. | Layer-by-layer (LbL)-engineered nanoparticles (NPs) are a promising group of therapeutic carriers used in an increasing number of biomedical applications. The present study uses a controlled LbL process to create a multidrug-loaded nanoplatform capable of promoting blood circulation time, biodistribution profile and co... | 25,169,256 | [
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Hydrothermal synthesis of Pt-Ag alloy nano-octahedra and their enhanced electrocatalytic activity for the methanol oxidation reaction. | The high-quality Pt48Ag52 alloy nano-octahedra are synthesized via one-pot hydrothermal method. The catalytic growth of Ag(0) atoms on Pt nuclei and selective oxidative etching on the Ag(0) atoms contribute to the formation of alloy nano-octahedra. Pt48Ag52 alloy nano-octahedra show excellent electrocatalytic activity ... | 25,169,420 | [
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Cephalometric analysis of craniofacial morphology and growth in unrepaired isolated cleft palate patients. | The aim of this study is to analyze the craniofacial morphology in patients with unrepaired isolated cleft palate (UICP) at childhood, adolescence and adulthood, in order to assess the influence of nonsurgical factors on the craniofacial growth in these patients. Lateral and posteroanterior cephalograms of 106 non-synd... | 25,169,446 | [
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Considerations and evidence for an ADHD outcome measure. | The 2011 American Academy of Pediatrics attention-deficit/hyperactivity disorder (ADHD) guideline emphasizes monitoring and measuring outcomes of children diagnosed with ADHD; however, recommendations for how to measure improvement are less clear. A long-term goal was to develop an outcome measure that assesses the qua... | 25,169,459 | [
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Population-based cervical cancer screening using high-risk HPV DNA test and liquid-based cytology in northern Thailand. | Northern Thailand is a region with a high cervical cancer incidence. Combined high-risk HPV (hrHPV) DNA testing and cytology (co-testing) has increasingly gained acceptance for cervical cancer screening. However, to our knowledge, data from a population-based screening using co-testing have not been available in this r... | 25,169,534 | [
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Association between the HSPA1B ±1267A/G polymorphism and cancer risk: a meta-analysis of 14 case-control studies. | Previous epidemiological studies have suggested a potential role of the HSPA1B±1267A/G polymorphism in risk of developing cancer. However, the results were inconsistent. Therefore, we performed this meta-analysis to summarize the possible association with cancer risk. We retrieved relevant articles from PubMed, EMBASE,... | 25,169,537 | [
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Activity and expression pattern of NF-κB /P65 in peripheral blood from hepatocellular carcinoma patients - link to hypoxia inducible factor -1α. | Hepatocellular carcinoma is a complex and heterogeneous tumor with poor prognosis due to frequent intrahepatic spread and extrahepatic metastasis. The molecular mechanisms underlying HCC pathogenesis still remain obscure. We aimed to investigate the abundance and the DNA binding activity of nuclear factor kappa B/p65 s... | 25,169,545 | [
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MiRNA-15a mediates cell cycle arrest and potentiates apoptosis in breast cancer cells by targeting synuclein-γ. | Recent studies have indicated that microRNA-15a (miR-15a) is dysregulated in breast cancer (BC). We aimed to evaluate the expression of miR-15a in BC tissues and corresponding para-carcinoma tissues. We also focused on effects of miR-15a on cellular behavior of MDA-MB-231 and expression of its target gene synuclein-γ (... | 25,169,552 | [
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Combined effects of six cytokine gene polymorphisms and SNP-SNP interactions on hepatocellular carcinoma risk in Southern Guangxi, China. | Cytokine gene single nucleotide polymorphisms (SNPs) are involved in the genesis and progression of hepatocellular carcinoma (HCC). We hypothesized that combined effects of cytokine gene SNPs and SNP-SNP interactions are associated with HCC risk. Six SNPs in cytokine genes (IL-2, IFN-γ, IL-1β, IL-6, and IL-10) were gen... | 25,169,554 | [
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Hypogonadism in the HIV-infected man. | Androgen deficiency occurs frequently in men with human immunodeficiency virus (HIV) infection. Antiretroviral treatments had reduced the prevalence of male hypogonadism. The pathogenesis of testosterone (T) deficiency in HIV is multifactorial. Several mechanisms have been proposed; among them, drugs, fat redistributio... | 25,169,563 | [
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Dynamic contrast-enhanced (DCE) MRI assessment of microvascular characteristics in the murine orthotopic pancreatic cancer model. | The aim of this study was to assess the dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)-derived pharmacokinetic parameters between two contrast agents in a murine orthotopic pancreatic cancer model and to evaluate the tumor heterogeneity and the potential association between kinetic parameters and angiog... | 25,169,584 | [
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Reverse genetics systems as tools for the development of novel therapies against filoviruses. | Filoviruses cause severe hemorrhagic fevers with case fatality rates of up to 90%, for which no antivirals are currently available. Their categorization as biosafety level 4 agents restricts work with infectious viruses to a few maximum containment laboratories worldwide, which constitutes a significant obstacle for th... | 25,169,588 | [
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Talking about cancer with confidence: evaluation of cancer awareness training for community-based health workers. | To examine the impact of cancer awareness training for community-based health workers on confidence to talk about cancer, and knowledge of cancer risk factors and signs and symptoms. Community-based health workers from Sandwell, Birmingham and Solihull were invited to take part in one of 14 one-day training workshops. ... | 25,169,613 | [
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[Mutation analysis of mucopolysaccharidosis type II and prenatal diagnosis]. | To analyze the mutations of IDS gene in a mucopolysaccharidosis type II (MPSII) family and to make prenatal diagnosis on the high-risk fetus which has been pregnant for eleven weeks. IDS gene was analyzed by bidirectional DNA sequencing in 2 patients and their mother, and 5 unaffected individuals. Prenatal diagnosis fo... | 25,169,630 | [
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Biooxidation of n-butane to 1-butanol by engineered P450 monooxygenase under increased pressure. | In addition to the traditional 1-butanol production by hydroformylation of gaseous propene and by fermentation of biomass, the cytochrome P450-catalyzed direct terminal oxidation of n-butane into the primary alcohol 1-butanol constitutes an alternative route to provide the high demand of this basic chemical. Moreover t... | 25,169,664 | [
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Hyperglycemia in the intensive care unit: is insulin the only option? | Current guidelines advocate the use of insulin for the management of hyperglycemia in the hospital setting. However, insulin is limited by a narrow therapeutic window, frequent errors, a need for expertise and systems-based monitoring, and lack of specificity for metabolic abnormalities that occur during critical illne... | 25,169,675 | [
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Age-specific incidence of all neoplasms after colorectal cancer. | Patients diagnosed with a specific neoplasm tend to have a subsequent excess risk of the same neoplasm. The age incidence of a second neoplasm at the same site is approximately constant with age, and consequently the relative risk is greater at younger age. It is unclear whether such a line of reasoning can be extended... | 25,169,681 | [
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Ethnicity and alcohol consumption among US adults with diabetes. | The drinking practices of a nationally representative sample of white, black, Mexican American, and other Hispanic adult diabetics are described and compared. Combined years (2005/2006-2011/2012) of the National Health and Nutrition Examination Survey provided home interview data from 2220 adults with self-reported dia... | 25,169,682 | [
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The experience of family members of ICU patients who require extensive monitoring: a qualitative study. | A mixed methods study using family research with a phenomenological approach (n = 5 families) was conducted to explore family members' perceptions about the extensive monitoring technology used on their critically ill family member after cardiac surgery, as experienced when family members initially visited the patient ... | 25,169,690 | [
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Epilepsy transition: challenges of caring for adults with childhood-onset seizures. | Children with severe chronic epilepsy are living longer, and they eventually transition to the adult health care system. Additional research is required to better define the population that is being transferred and the qualifications of those who are assuming their care. We aimed to evaluate the complexity of epilepsy ... | 25,169,716 | [
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0.2019543,
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Photocatalytic degradation of selected anticancer drugs and identification of their transformation products in water by liquid chromatography-high resolution mass spectrometry. | A study on the fate of two antineoplastic drugs, methotrexate and doxorubicin, in the aquatic environment is presented. The investigation involved a study of their decomposition under dark experiments, homogeneous photolysis and heterogeneous photocatalysis using titanium dioxide, the identification of intermediate com... | 25,169,721 | [
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Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling. | Progranulin (PGRN) was previously isolated as an osteoarthritis (OA)-associated growth factor. Additionally, PGRN was found to play a therapeutic role in inflammatory arthritis mice models through antagonising tumour necrosis factor α (TNF-α). This study was aimed at investigating the role of PGRN in degradation of car... | 25,169,730 | [
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Validating screening tools for depression in epilepsy. | Depression is a common comorbidity of epilepsy, and its timely identification in persons with epilepsy is essential. The use of screening tools to detect depression is common in epilepsy, but some scales in current use have not been validated using a gold standard in this population. The present study aims to validate ... | 25,169,800 | [
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Programmable co-assembly of oppositely charged microgels. | Here we report the development of an aqueous, self-assembling system of oppositely charged colloids leading towards particle arrangements with controlled order. The colloidal system consists of two types of particles, each consisting of refractive index matched colloidal core-shell microgel particles, which are either ... | 25,169,820 | [
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Early life stress shapes female reproductive strategy through eggshell pigmentation in Japanese quail. | Physiological constraints on colouration have been widely reported; especially in birds, which trade-off antioxidant responses against colourful costly signals. One female extended phenotypic trait, which might also highlight important physiological trade-offs, is the pigmentation of their eggshells. In ground-nesting ... | 25,169,834 | [
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Burden of chronic obstructive pulmonary disease in the elderly population. | Chronic obstructive pulmonary disease (COPD) is a common disease and an important health care problem in older adults. The impact of age and specific geriatric issues on COPD in elderly patients has not been well established. A cross-sectional study of elderly COPD patients was conducted in Japan by using a regional CO... | 25,169,845 | [
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Genome Sequence of Paenibacillus polymyxa Strain CICC 10580, Isolated from the Fruit of Noni (Morinda citrifolia L.) Grown in the Paracel Islands. | Noni is a plant reported to have nutritional and therapeutic properties. Paenibacillus polymyxa CICC 10580 is a strain that was isolated from the fruit of noni and showed comprehensive antagonistic activity against many pathogens. Its genome was sequenced and assembled (6.10 Mb). The coding sequences (CDSs) correlated ... | 25,169,860 | [
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Draft Genome Sequence of the Fish Pathogen Yersinia ruckeri Strain 37551, Serotype O1b, Isolated from Diseased, Vaccinated Atlantic Salmon (Salmo salar) in Chile. | We sequenced the genome of a motile O1b Yersinia ruckeri field isolate from Chile, which is causing enteric redmouth disease (ERM) in vaccinated Atlantic salmon (Salmo salar). The draft genome has 3,775,486 bp, a G+C content of 47.1%, and is predicted to contain 3,406 coding sequences. | 25,169,862 | [
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Clinical, EEG, MRI, MEG, and surgical outcomes of pediatric epilepsy with astrocytic inclusions versus focal cortical dysplasia. | Astrocytic inclusions (AIs) have been identified on histologic specimens of patients with early onset seizures, and the proteomic contents have been described. The aim of this study was to compare the clinical, electroencephalography (EEG), magnetoencephalography (MEG), magnetic resonance imaging (MRI), and surgical ou... | 25,169,867 | [
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Computational design of patterned interfaces using reduced order models. | Patterning is a familiar approach for imparting novel functionalities to free surfaces. We extend the patterning paradigm to interfaces between crystalline solids. Many interfaces have non-uniform internal structures comprised of misfit dislocations, which in turn govern interface properties. We develop and validate a ... | 25,169,868 | [
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Assessing uncertainty in pollutant wash-off modelling via model validation. | Stormwater pollution is linked to stream ecosystem degradation. In predicting stormwater pollution, various types of modelling techniques are adopted. The accuracy of predictions provided by these models depends on the data quality, appropriate estimation of model parameters, and the validation undertaken. It is well u... | 25,169,872 | [
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Prevalence, incidence, and comorbidity of clinically diagnosed obsessive-compulsive disorder in Taiwan: a national population-based study. | Obsessive-compulsive disorder (OCD) is a chronic debilitating anxiety disorder significant in intrusive thoughts and compensation repetitive behaviors. Few studies have reported on this condition Asia. This study estimated the prevalence, incidence and psychiatric comorbidities of OCD in Taiwan. We identified study sub... | 25,169,892 | [
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Socio-demographic vulnerability to heatwave impacts in Brisbane, Australia: a time series analysis. | Examining the association between socioeconomic disadvantage and heat-related emergency department (ED) visits during heatwave periods in Brisbane, 2000-2008. Data from 10 public EDs were analysed using a generalised additive model for disease categories, age groups and gender. Cumulative relative risks (RR) for non-ex... | 25,169,903 | [
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Saikosaponin-D attenuates heat stress-induced oxidative damage in LLC-PK1 cells by increasing the expression of anti-oxidant enzymes and HSP72. | Heat stress stimulates the production of reactive oxygen species (ROS), which cause oxidative damage in the kidney. This study clarifies the mechanism by which saikosaponin-d (SSd), which is extracted from the roots of Bupleurum falcatum L, protects heat-stressed pig kidney proximal tubular (LLC-PK1) cells against oxid... | 25,169,909 | [
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Electrodermal screening of biologically active points for upper gastrointestinal bleeding. | The purpose of this case-control study was to investigate the relationship between the electrical resistance of the skin at biologically active points (BAPs) on the main meridians and upper gastrointestinal bleeding (UGIB). Electrical resistance to direct current at 20 BAPs on the fingers and toes of 100 patients with ... | 25,169,911 | [
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Vitamin D receptor gene polymorphisms and the risk of Parkinson's disease. | The effect of vitamin D receptor (VDR) gene polymorphisms on Parkinson's disease (PD) has recently gained interest. However, evidence on this relationship is controversial. We searched PubMed, EMBASE and the Cochrane Library database targeted all studies that evaluated VDR gene polymorphisms and PD up to April 2,014. A... | 25,169,913 | [
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Thoracoscopic repair of esophageal atresia and tracheo-esophageal fistula in neonates: the current state of the art. | The first thoracoscopic esophageal atresia with tracheo-esophageal fistula (EATEF) repair was performed in March of 2000. This report evaluates the results and evolution of the technique over the last decade. Thoracoscopic esophageal atresia repair has proven to be an effective and safe technique. Initial experience re... | 25,169,923 | [
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Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury. | Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ... | 25,169,927 | [
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A transcriptomic approach to ribbon worm systematics (nemertea): resolving the pilidiophora problem. | Resolving the deep relationships of ancient animal lineages has proven difficult using standard Sanger-sequencing approaches with a handful of markers. We thus reassess the relatively well-studied phylogeny of the phylum Nemertea (ribbon worms)-for which the targeted gene approaches had resolved many clades but had lef... | 25,169,929 | [
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The impact of bacteremia on the outcome of bone infections. | We have used a medical database to analyze our activity since 2005. We observed a frequent association between bone and joint infection (BI) and bacteremia. Our aim was to characterize patients with BI and bacteremia, and focus on the outcome. Our database includes the prospective recording of 28 characteristics of all... | 25,169,941 | [
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Awake extracorporeal membrane oxygenation bridging for pulmonary retransplantation provides comparable results to elective retransplantation. | Lung retransplantation became an accepted treatment for bronchiolitis obliterans syndrome (BOS). However, the value of different bridging modalities for these patients is controversial. We analyzed outcomes of 39 patients listed for retransplantation between 2008 and 2012. Patients were divided in 3 groups: 23 patients... | 25,169,957 | [
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Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. | Pressure overload-induced TGF-β signaling activates cardiac fibroblasts (CFB) and leads to increased extracellular matrix (ECM) protein synthesis including fibrosis. Excessive ECM accumulation may in turn affect cardiac function contributing to development of heart failure. The aim of this study was to examine the effe... | 25,169,971 | [
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Reducing Deviance Through Youths' Mutual Aid Group Dynamics. | The mutual aid group, as supported by the social worker, emerges to play a vital role in helping group members reduce their deviance or behavioral problem. However, how the collaboration of the group and social worker accomplishes the reduction has remained uncharted. Based on social capital theory, mutual aid and cohe... | 25,169,973 | [
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Gene transfers shaped the evolution of de novo NAD+ biosynthesis in eukaryotes. | NAD(+) is an essential molecule for life, present in each living cell. It can function as an electron carrier or cofactor in redox biochemistry and energetics, and serves as substrate to generate the secondary messenger cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate. Although de novo NAD(+) biosynt... | 25,169,983 | [
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Prevalence of glucose-6-phosphate dehydrogenase deficiency and the role of the A- variant in a Saudi population. | To estimate the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among Saudi men, and to establish the frequency of the two mutations/polymorphisms associated with the G6PD A- mutation--G to A at nucleotide 202 (G202A) and A to G at nucleotide 376 (A376G)--in those found to have G6PD deficiency. Blood ... | 25,169,987 | [
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Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells. | The retinoid X receptor (RXR) partners with numerous nuclear receptors, such as the peroxisome proliferator activated receptor (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR). Although each heterodimer can be activated by specific ligands, a subset of these receptors, defined as permissive nucle... | 25,169,989 | [
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Noxious family environments in relation to adult and childhood caries. | The authors tested hypotheses that more noxious family environments are associated with poorer adult and child oral health. A community sample of married or cohabiting couples (N = 135) and their elementary school-aged children participated. Dental hygienists determined the number of decayed, missing and filled surface... | 25,169,999 | [
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0.05957711,
... |
The relationship between various parameters of complete denture quality and patients' satisfaction. | Patients' appreciation of their conventional complete dentures might be affected by the quality of the dentures. A random sample of 33 edentulous patients who were rehabilitated by means of conventional complete dentures participated in the study. Three independent investigators who underwent technique calibration eval... | 25,170,001 | [
0.2941623,
0.3805045,
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0.02218978,
0.09111688,
0.08868916,
0.1948862,
... |
Exclusion of older patients from ongoing clinical trials for hematological malignancies: an evaluation of the National Institutes of Health Clinical Trial Registry. | Cancer societies, research cooperatives, and countless publications have urged the development of clinical trials that facilitate the inclusion of older patients and those with comorbidities. We set out to determine the characteristics of currently recruiting clinical trials with hematological patients to assess their ... | 25,170,014 | [
-0.04008311,
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0.144606,
0.1021408,
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0.... |
An exploratory fMRI study into inferences of self-agency. | Building on the recent findings that the experience of self-agency over actions and corresponding outcomes can also rely on cognitive inferential processes, rather than motor prediction processes, this study aims to investigate the brain areas involved in agency inference processing in a setting where action and outcom... | 25,170,021 | [
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0.101326,
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0.006367803,
0.02201314,
0.2544692,
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Standardised clients as assessors in a veterinary communication OSCE: a reliability and validity study. | In human medicine, standardised patients (SP) have been shown to reliably and accurately assess learners' communication performance in high-stakes certification Objective Structured Clinical Examinations (OSCE), offering a feasible way to reduce the need for recruitment, time commitment and coordination of faculty asse... | 25,170,035 | [
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T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. | The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (T(RM) cells), non-recirculating cells located at common sites... | 25,170,049 | [
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Infection of influenza virus neuraminidase-vaccinated mice with homologous influenza virus leads to strong protection against heterologous influenza viruses. | Vaccination is the best measure to prevent influenza pandemics. Here, we studied the protective effect against heterologous influenza viruses, including A/reassortant/NYMC X-179A (pH1N1), A/Chicken/Henan/12/2004 (H5N1), A/Chicken/Jiangsu/7/2002 (H9N2) and A/Guizhou/54/89×A/PR/8/34 (A/Guizhou-X) (H3N2), in mice first va... | 25,170,051 | [
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A deregulated intestinal cell cycle program disrupts tissue homeostasis without affecting longevity in Drosophila. | Recent studies illuminate a complex relationship between the control of stem cell division and intestinal tissue organization in the model system Drosophila melanogaster. Host and microbial signals drive intestinal proliferation to maintain an effective epithelial barrier. Although it is widely assumed that proliferati... | 25,170,078 | [
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. | It has recently been appreciated that the angiotensin II type 1 receptor (AT1R), a prototypic member of the G protein-coupled receptor superfamily, also functions as a mechanosensor. Specifically, mechanical stretch activates the AT1R to promote downstream signaling mediated exclusively by the multifunctional scaffold ... | 25,170,081 | [
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0.1062715,
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Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, Cys-XX-Cys-His. | Mitochondrial cytochrome c assembly requires the covalent attachment of heme by thioether bonds between heme vinyl groups and a conserved CXXCH motif of cytochrome c/c1. The enzyme holocytochrome c synthase (HCCS) binds heme and apocytochrome c substrate to catalyze this attachment, subsequently releasing holocytochrom... | 25,170,082 | [
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0.09621996,
0.2481904,
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The association between dialysis modality and the risk for dialysis technique and non-dialysis technique-related infections. | Infections are a major cause of morbidity and mortality among dialysis patients. Dialysis modality has been hypothesized to be a potential immunomodulatory factor. The objective of this study was to determine the influence of the first dialysis modality on the risk for infections on dialysis. Our study was conducted ut... | 25,170,096 | [
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0.... |
Na⁺/H⁺ exchanger 1 participates in tobacco disease defence against Phytophthora parasitica var. nicotianae by affecting vacuolar pH and priming the antioxidative system. | Despite the importance of NHX1 (Na(+)/H(+) exchanger 1) in plant salt tolerance, little is known about its other functions. In this study, intriguingly, it was found that NHX1 participated in plant disease defence against Phytophthora parasitica var. nicotianae (Ppn) in Nicotiana benthamiana. NbNHX1 was originally isol... | 25,170,102 | [
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0.5603989,
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<i>Corallina</i> and <i>Ellisolandia</i> (Corallinales, Rhodophyta) photophysiology over daylight tidal emersion: interactions with irradiance, temperature and carbonate chemistry. | The photophysiology of three geniculate coralline algal species (<iCorallina officinalis</i, <iC. caespitosa</i and <iEllisolandia elongata</i) was determined in intertidal rock pools in the south-west UK at Combe Martin (51°12'31N 4°2'19W) and Heybrook Bay (50°31'66N 4°11'41W), at the start, middle and end of summer (... | 25,170,177 | [
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0.3747591,
0.2574591,
0.3490948,
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... |
The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. | Injectable blood persistent particulate carriers have important therapeutic application in site-specific drug delivery or medical imaging. However, injected particles are generally eliminated by the reticuloendothelial system within minutes after administration and accumulate in the liver and spleen. To obtain a coatin... | 25,170,183 | [
0.03656276,
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0.166225,
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0.4068884,
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... |
A red tide of Alexandrium fundyense in the Gulf of Maine. | In early July 2009, an unusually high concentration of the toxic dinoflagellate <iAlexandrium fundyense</i occurred in the western Gulf of Maine, causing surface waters to appear reddish brown to the human eye. The discolored water appeared to be the southern terminus of a large-scale event that caused shellfish toxici... | 25,170,191 | [
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0.5414085,
0.1399406,
... |
Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis. | To investigate the efficacy of moxibustion in ulcerative colitis (UC) rats from morphological, immunological and molecular biological perspectives. Thirty-two Sprague-Dawley rats were randomly assigned to a blank control group (normal rats, n = 6) and a model replication (MR) group (UC rats, n = 26). A UC model was est... | 25,170,214 | [
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0.3407961,
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Gastrointestinal symptoms: a comparison between patients undergoing peritoneal dialysis and hemodialysis. | To compare the prevalence and diversity of gastrointestinal (GI) symptoms in patients undergoing peritoneal dialysis (PD) and hemodialysis (HD). Two hundred and ninety-four end-stage renal disease patients participated in the study, including 182 HD and 112 PD patients. Dimension scores were calculated from a modified ... | 25,170,224 | [
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Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion. | To evaluate preventative effects of glutamine in an animal model of gut ischemia/reperfusion (I/R). Male Wistar rats were housed in a controlled environment and allowed access to food and water ad libitum. Twenty male Wistar rats were divided into four experimental groups: (1) control group (control) - rats underwent e... | 25,170,229 | [
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... |
There is Room for Even More Doublethink: The Perilous Status of Psychoanalytic Research. | The opposition between psychoanalysis and systematic interdisciplinary research is to be regretted. The target article attempts to bridge the intellectual divide and for this aim as well as the intellectual adroitness shown it is to be celebrated. Much harder to understand is the high level of affect generated by the d... | 25,170,240 | [
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0.08942818,
0.009643099,
-0.07553832... |
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