title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A homologous series of [Fe(H₂Bpz₂)₂(L)] spin-crossover complexes with annelated bipyridyl co-ligands. | Four new iron(II) complexes [Fe(H2Bpz2)2(L)] were prepared (pz = pyrazolyl), where L is dipyrido[3,2-f:2',3'-h]quinoxaline (dpq), dipyrido[3,2-a:2'3'-c]phenazine (dppz), dipyrido[3,2-a:2'3'-c]benzo[i]-phenazine (dppn), and dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazine (dppc). Crystal structures of [Fe(H2Bpz2)2(d... | 25,171,341 | [
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Reappraising roles. | After its August break, Nursing Older People welcomes you back. I hope that you all managed to take a rest from work too and had an enjoyable summer. | 25,171,345 | [
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MPs urged to keep assisted dying high on the agenda. | MPS ARE being urged by a leading nurse to keep the controversial issue of assisted dying 'high on the political agenda' in the run up to the general election. | 25,171,351 | [
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Test and learn: Working towards integrated services. | By 2018 the government expects integrated health and social care to become the norm in England. From next April a £3.8 billion pooled budget called the Better Care Fund will be launched to support service redesign for integrated care. The overall aim of the integration policy is to shift more care into the community to... | 25,171,364 | [
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Thermophoretic manipulation of molecules inside living cells. | The complexity of biology requires that measurements of biomolecular interactions be performed inside living cells. While electrophoresis inside cells is prohibited by the cell membrane, the movement of molecules along a temperature gradient appears feasible. This thermophoresis could be used to quantify binding affini... | 25,171,388 | [
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Monkeys rely on recency of stimulus repetition when solving short-term memory tasks. | Seven monkeys performed variants of two short-term memory tasks that others have used to differentiate between selective and nonselective memory mechanisms. The first task was to view a list of sequentially presented images and identify whether a test matched any image from the list, but not a distractor from a precedi... | 25,171,424 | [
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Ovarian germinoma accelerating the presentation of diabetes mellitus. | A 12-year-old girl presented to the Children's Emergency Department with symptoms of diabetes mellitus. Glutamic acid decarboxylase autoantibodies and anti-Islet cell antibodies were absent. She was also found to have ovarian dysgerminoma with markedly elevated serum β-human chorionic gonadotropin (β-HCG). With treatme... | 25,171,445 | [
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Comparison of three tracheal intubation techniques in thyroid tumor patients with a difficult airway: a randomized controlled trial. | To investigate the effectiveness of the Shikani optical stylet (SOS) and GlideScope video laryngoscope (GVL) for tracheal intubation of thyroid tumor patients with a difficult airway. One hundred and twenty thyroid tumor patients with a difficult airway, who were undergoing elective surgery requiring general anesthesia... | 25,171,459 | [
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Preparation of carbon-coated iron nanofluid and its application in radiofrequency ablation. | Carbon-coated iron nanoparticles (Fe@C CCINs) were synthesized by carbon arc discharge method and were studied via X-ray diffraction (XRD) and transmission electron microscopy (TEM). The results showed that CCINs have good core-shell structure and are in size of 40-50 nm. Also, carbon-coated iron nanofluid (CCINs-nanof... | 25,171,467 | [
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The interleukin-10-1082A>G polymorphism and lymphoma risk: a meta-analysis. | The Interleukin-10 (IL-10) gene polymorphism (-1082 A>G) has been linked to the risk of developing lymphoma, but the available results were inconsistent. To derive a more precise estimation, we performed a meta-analysis. A comprehensive search was conducted to examine all the eligible studies about IL-10-1082A>G ... | 25,171,480 | [
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Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: a meta-analysis. | Loss of Raf kinase inhibitor protein (RKIP) may contribute to metastasis in a variety of human cancers. Many studies have evaluated whether loss of RKIP expression is a prognostic factor for survival in cancers of the digestive system, however, its predictive value remains controversial. Thus, we performed a meta-analy... | 25,171,481 | [
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Development of a method to quantify the DNA content in cationic peptide-DNA nanoparticles. | Gene therapy has the potential to provide safe and targeted therapies for a variety of diseases. A range of intracellular gene delivery vehicles have been proposed for this purpose. Non-viral vectors are a particularly attractive option and among them cationic peptides have emerged as promising candidates. For the phar... | 25,171,486 | [
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Quantum-size-controlled photoelectrochemical fabrication of epitaxial InGaN quantum dots. | We demonstrate a new route to the precision fabrication of epitaxial semiconductor nanostructures in the sub-10 nm size regime: quantum-size-controlled photoelectrochemical (QSC-PEC) etching. We show that quantum dots (QDs) can be QSC-PEC-etched from epitaxial InGaN thin films using narrowband laser photoexcitation, an... | 25,171,507 | [
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Prospect theory based estimation of drivers' risk attitudes in route choice behaviors. | This paper applied prospect theory (PT) to describe drivers' route choice behavior under Variable Message Sign (VMS), which presented visual traffic information to assist them to make route choice decisions. A quite rich empirical data from questionnaire and field spot was used to estimate parameters of PT. In order to... | 25,171,520 | [
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Impact of hypertriglyceridemia on the outcome of acute biliary pancreatitis. | Hypertriglyceridemia (HTG) is a well-recognized cause of acute pancreatitis (AP). However, the role of HTG in modulating disease course remains to be cleared. We aimed to explore the impact of HTG on the outcome of acute biliary pancreatitis (ABP). A total of 90 ABP patients with HTG were enrolled in this study and wer... | 25,171,545 | [
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Depression and anxiety symptoms in mothers of newborns hospitalized on the neonatal intensive care unit. | Mothers of infants hospitalized in the neonatal intensive care unit (NICU) are at risk for clinically significant levels of depression and anxiety symptoms; however, the maternal/infant characteristics that predict risk have been difficult to determine. Previous studies have conceptualized depression and anxiety sympto... | 25,171,558 | [
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Managing heart failure in the long-term care setting: nurses' experiences in Ontario, Canada. | Implementation of heart failure guidelines in long-term care (LTC) settings is challenging. Understanding the conditions of nursing practice can improve management, reduce suffering, and prevent hospital admission of LTC residents living with heart failure. The aim of the study was to understand the experiences of LTC ... | 25,171,561 | [
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Timing of cleft lip and palate repair. | The opinions presented below concerning the choice of the timing of the cleft lip and palate repair have been presented on the basis of the literature and own experience. The comments and attempts to make an assessment reflect both direct contacts with representatives of numerous centres conducting interdisciplinary tr... | 25,171,626 | [
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Crystallization of methyl ammonium lead halide perovskites: implications for photovoltaic applications. | Hybrid organic/lead halide perovskites are promising materials for solar cell fabrication, resulting in efficiencies up to 18%. The most commonly studied perovskites are CH3NH3PbI3 and CH3NH3PbI3-xClx where x is small. Importantly, in the latter system, the presence of chloride ion source in the starting solutions used... | 25,171,634 | [
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Eating habits of patients with cleft lip and palate terated with fixed appliances. | Health education, built on the basis of various models as a lifelong process, has a considerable impact on eating habits. Correct nutritional patterns are particularly important during the period of intense growth and adolescence. The need to observe dietary recommendations concerns healthy, as well as sick persons, es... | 25,171,628 | [
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Early and late complications of germinal matrix-intraventricular haemorrhage in the preterm infant: what is new? | Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a serious problem in the very and extremely preterm infant. This article reviews current methods of diagnosis, treatment and neurodevelopmental outcome in preterm infants with low-grade and severe GMH-IVH. We conclude that there is still no consensus on tim... | 25,171,657 | [
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Effectiveness of intra-articular injection in wrist joints according to triamcinolone hexacetonide dose in rheumatoid arthritis: a randomized controlled double-blind study. | The aim of this study was to compare the effectiveness in the medium term between low and high doses of triamcinolone hexacetonide used in intra-articular injection in medium-sized joints of rheumatoid arthritis (RA) patients. A randomized double-blind study was carried out in rheumatoid arthritis patients with wrist p... | 25,171,663 | [
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Whole-body strength training using a Huber Motion Lab in coronary heart disease patients: safety, tolerance, fuel selection, and energy expenditure aspects and optimization. | The aim of this study was to investigate safety, tolerance, relative exercise intensity, and muscle substrate oxidation during sessions performed on a Huber Motion Lab in coronary heart disease patients. After an assessment of Vo2 peak, 20 coronary heart disease patients participated in two different exercises performe... | 25,171,664 | [
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Symptoms induced by transgenic expression of p23 from Citrus tristeza virus in phloem-associated cells of Mexican lime mimic virus infection without the aberrations accompanying constitutive expression. | Citrus tristeza virus (CTV) is phloem restricted in natural citrus hosts. The 23-kDa protein (p23) encoded by the virus is an RNA silencing suppressor and a pathogenicity determinant. The expression of p23, or its N-terminal 157-amino-acid fragment comprising the zinc finger and flanking basic motifs, driven by the con... | 25,171,669 | [
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Do stress markers and anesthetic technique predict delirium in the elderly? | Postoperative delirium (PD) is a prevalent complication of elderly surgical patients, which predisposes to worsened cognitive recovery and dementia. Risk of PD has been associated with increasing magnitude of the hypothalamic-pituitary-adrenal stress response (serum cortisol, epinephrine and norepinephrine) to surgery.... | 25,171,689 | [
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Fifteen years' experience of a College of American Pathologists program for continuous monitoring and improvement. | The Q-Tracks program, created in 1999, is a quality monitoring subscription service offered by the College of American Pathologists. To establish benchmarks in quality metrics, monitor changes in performance over time, and identify practice characteristics associated with better performance. The Q-Tracks program provid... | 25,171,697 | [
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Modulation of α-enolase post-translational modifications by dengue virus: increased secretion of the basic isoforms in infected hepatic cells. | Hepatic cells are major sites of dengue virus (DENV) replication and liver injury constitutes a characteristic of severe forms of dengue. The role of hepatic cells in dengue pathogenesis is not well established, but since hepatocytes are the major source of plasma proteins, changes in protein secretion by these cells d... | 25,171,719 | [
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Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood. | Although breastfed infants have consistently been reported as having fewer infections and respiratory morbidity during infancy, none have reached a definitive conclusion as to whether breastfeeding is an effective strategy to prevent allergic diseases. This study aims to investigate the relationship between exclusive b... | 25,171,739 | [
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Lack of the NS5B S282T mutation in HCV isolates from liver tissue of treatment-naive patients with HCV genotype-1b infection. | Despite the availability of several direct-acting antivirals (DAAs) specifically inhibiting different HCV proteins, treatment of chronic HCV infection is still a challenge also because of the possible selection of resistant viral variants under DAA therapy. Indeed, only the emergence of viruses resistant to the nucleos... | 25,171,743 | [
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Linear-selective hydroarylation of unactivated terminal and internal olefins with trifluoromethyl-substituted arenes. | We report a series of hydroarylations of unactivated olefins with trifluoromethyl-substituted arenes that occur with high selectivity for the linear product without directing groups on the arene. We also show that hydroarylations occur with internal, acyclic olefins to yield linear alkylarene products. Experimental mec... | 25,171,744 | [
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The cold-rolling behaviour of AZ31 tubes for fabrication of biodegradable stents. | Mg alloys are receiving considerable attention for biomedical stents due to their combination of good mechanical properties and high biodegradability. Cold rolling is necessary to process Mg alloy tubes before final drawing and fabrication of the magnesium stents. In this paper, cold-rolled tubes were subjected to a cr... | 25,171,746 | [
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The toolbox of Trichoderma spp. in the biocontrol of Botrytis cinerea disease. | Botrytis cinerea is a necrotrophic fungal pathogen causing disease in many plant species, leading to economically important crop losses. So far, fungicides have been widely used to control this pathogen. However, in addition to their detrimental effects on the environment and potential risks for human health, increasin... | 25,171,761 | [
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Spatial ecotoxicology: migratory Arctic seabirds are exposed to mercury contamination while overwintering in the northwest Atlantic. | Arctic organisms are exposed to various levels of pollutants, among which mercury (Hg) has raised important environmental concerns. Previous studies examining Hg levels, trends, and effects on Arctic marine top predators have focused on the Arctic region. However, many of these top predators, such as seabirds, migrate ... | 25,171,766 | [
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Relationship between the shape and density distribution of the femur and its natural frequencies of vibration. | It has been recently suggested that mechanical loads applied at frequencies close to the natural frequencies of bone could enhance bone apposition due to the resonance phenomenon. Other applications of bone modal analysis are also suggested. For the above-mentioned applications, it is important to understand how patien... | 25,171,786 | [
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Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia. | Toll-like receptor-4 (TLR4) has been identified in primary sensory neurons, both in vivo and in vitro, but is reportedly absent from satellite glial cells (SGCs). Herein we reveal that, in rat dorsal root ganglia (DRG), SGCs do express TLR4 but this expression is inhibited by direct contact with neurons. Thus, TLR4 mRN... | 25,171,787 | [
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Can the new McGrath laryngoscope rival the GlideScope Ranger portable video laryngoscope? A randomized manikin study. | We hypothesized that novices would be able to use the McGrath MAC (Aircraft Medical Ltd, Edinburgh, UK) equally as well as the GlideScope Ranger (Verathon, Inc, Bothell, WA) for intubation in regular simulated airways. We performed a prospective, randomized crossover study of 39 medical students using the McGrath MAC, ... | 25,171,799 | [
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Relationship between the hemodynamic changes on multi-Td pulsed arterial spin labeling images and the degrees of cerebral artery stenosis. | To explore the relationship between the hemodynamic changes on multi-Td (delay time) pulsed arterial spin labeling (PASL) images and the degrees of cerebral artery stenosis, and to evaluate the value of multi-Td PASL in detecting the signal changes in cerebral arteries with stenosis. 29 patients with less than 50% sten... | 25,171,819 | [
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Cultural consonance, constructions of science and co-existence: a review of the integration of traditional, complementary and alternative medicine in low- and middle-income countries. | This review examined the determinants, patterns and imports of official recognition, and incorporation of different traditional, complementary and alternative systems of medicine (TCAM) in the public health establishment of low- and middle-income countries, with a particular focus on India. Public health systems in mos... | 25,171,821 | [
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[Consensus document for the detection and management of chronic kidney disease]. | Chronic kidney disease (CKD) is an important global health problem, involving to 10% of the Spanish population, promoting high morbidity and mortality for the patient and an elevate consumption of the total health resources for the National Health System. This is a summary of an executive consensus document of ten scie... | 25,171,835 | [
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The salt content of products from popular fast-food chains in Costa Rica. | Salt is a major determinant of population blood pressure levels. Salt intake in Costa Rica is above levels required for good health. With an increasing number of Costa Ricans visiting fast food restaurants, it is likely that fast-food is contributing to daily salt intake. Salt content data from seven popular fast food ... | 25,171,851 | [
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Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat. | A relationship has been shown between preeclampsia (PE) and intrauterine growth restriction (IUGR) and oxidative stress (OS). Since such pregnancies experience OS, we aimed to detect the distribution pattern and expression levels of a transcription factor, Nuclear factor erythroid 2-related factor-2 (Nrf2) that has a r... | 25,171,874 | [
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Development of a non-blurring, dual-imaging tissue marker for gastrointestinal tumor localization. | Knowing the exact location of gastrointestinal tumors both preoperatively and intraoperatively is essential for planning and performing laparoscopic surgery. Different techniques have been introduced to ascertain tumor locations during surgery, but none of these are fully satisfactory at establishing the minimum margin... | 25,171,886 | [
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Imaging frontotemporal lobar degeneration. | The term frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders that target the frontal and temporal lobes. It accounts for approximately 10 % of pathologically confirmed dementias but has been demonstrated to be as prevalent as Alzheimer's disease in patients below the age of 65. The... | 25,171,901 | [
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Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan. | To identify sociodemographic and clinical factors predicting the overall risk of adverse obstetric outcomes and the length of maternal hospital stay among heroin-exposed and methadone-treated women in Taiwan. Using the retrospective matched cohort study design, 396 births to women on methadone treatment during pregnanc... | 25,171,908 | [
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Sexual identity, same-sex partners and risk behaviour among a community-based sample of young people in Australia. | Young people who are same-sex attracted report higher rates of substance use, sexual risk behaviour, and mental health problems. Numerous studies have shown that sexual identity, sexual behaviour and sexual attraction do not always correspond, particularly among young people. We describe sexual identity, sexual partner... | 25,171,911 | [
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Lights and shadows of anti-HLA antibodies detected by solid-phase assay. | Recently, management of patients awaiting solid organ transplantation has taken advantages after the development of more sensitive and accurate solid phase assays which have supported the historic complement dependent cytotoxicity. This approach has allowed the detection of antibodies in patients previously considered ... | 25,171,913 | [
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Microsatellite-centromere mapping in common carp through half-tetrad analysis in diploid meiogynogenetic families. | Gene-centromere (G-C) mapping provides insights into the understanding of the composition, structure, and evolution of vertebrate genomes. Common carp (Cyprinus carpio) is an important aquaculture fish and has been proposed to undertake tetraploidization. In this study, we selected 214 informative microsatellite marker... | 25,171,918 | [
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Automated medical resident rotation and shift scheduling to ensure quality resident education and patient care. | At academic teaching hospitals around the country, the majority of clinical care is provided by resident physicians. During their training, medical residents often rotate through various hospitals and/or medical services to maximize their education. Depending on the size of the training program, manually constructing s... | 25,171,938 | [
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Allergy and risk of hematologic malignancies: associations and mechanisms. | Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent. Th... | 25,171,954 | [
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Virtual screening strategies: recent advances in the identification and design of anti-cancer agents. | Virtual screening (VS) is a well-established technique, which is now routinely employed in computer aided drug designing process. VS can be broadly classified into two categories, i.e., ligand-based and structure-based approach. In recent years, VS has emerged as a time saving and cost effective technique, capable of s... | 25,171,960 | [
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Indocyanine green videoangiography methodological variations: review. | Indocyanine green videoangiography (ICGVA) procedures have become widespread within the spectrum of microsurgical techniques for neurovascular pathologies. We have conducted a review to identify and assess the impact of all of the methodological variations of conventional ICGVA applied in the field of neurovascular pat... | 25,171,963 | [
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Serum lactate as a potential biomarker of malignancy in primary adult brain tumours. | Lactate, a by-product of glycolysis, is an indicator of poor tissue perfusion and is a useful biomarker with prognostic value in risk-stratifying patients in several diseases. Furthermore, elevated lactate production is observed in tumour glycolysis, also known as the Warburg effect, and is essential in promoting tumou... | 25,172,017 | [
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Revision of primary total hip arthroplasty for peri-prosthetic fracture: A prospective epidemiological study of 249 consecutive cases in France. | Revision total hip arthroplasty (reTHA) for peri-prosthetic fracture (PPF) is increasingly performed but still ranks fourth among reasons for reTHA in registries. In France, no specific registry is available and the frequency of PPF among reasons for THA revision is therefore unknown. Here, our objectives were to deter... | 25,172,019 | [
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Clinical laboratory data: acquire, analyze, communicate, liberate. | The availability of portable healthcare devices, which can acquire and transmit medical data to remote experts would dramatically affect healthcare in areas with poor infrastructure. Smartphones, which feature touchscreen computer capabilities and sophisticated cameras, have become widely available with over billion un... | 25,172,035 | [
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Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis. | Lymph node metastasis in dogs with mast cell tumour has been reported as a negative prognostic indicator; however, no standardized histological criteria exist to define metastatic disease. The primary aim of this study was to determine whether different histological patterns of node-associated mast cells correlate with... | 25,172,053 | [
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Platelet-derived growth factors and receptors in Canine Lymphoma. | Platelet-derived growth factors (PDGFs) belong to a family of polypeptide growth factors that signal through cell surface tyrosine kinase receptors to stimulate growth, proliferation and differentiation. Platelet-derived growth factor receptors (PDGFRs) are also considered important targets for specific kinase inhibito... | 25,172,054 | [
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Consumption of 2-chlorophenol using anaerobic sludge: physiological and kinetic analysis. | Chlorophenols are toxic and recalcitrant compounds produced by many industrial. Different strategies have been used to improve their biological consumption, but there is insufficient information to understand how the process is carried out. The objective of this study was to evaluate in batch tests the effect of the ad... | 25,172,056 | [
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Nutrition and cardiovascular health. | A multitude of studies have been published on the relationship between cardiovascular disease risk and a variety of nutrients, foods, and dietary patterns. Despite the well-accepted notion that diet has a significant influence on the development and prevention of cardiovascular disease, the foods considered healthy and... | 25,172,070 | [
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Imaging techniques in the evaluation of post-infarction function and scar. | Imaging techniques are essential in the clinical evaluation of patients with a myocardial infarction. They are of value for both initial assessment of the ischemic injury and for detection of the subgroup of patients at higher risk of developing cardiovascular events during follow-up. Echocardiography remains the techn... | 25,172,072 | [
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Heat stress during the Black Saturday event in Melbourne, Australia. | The Black Saturday bushfire event of February 7, 2009, devastated the state of Victoria, Australia, resulting in 173 deaths. On this day, the maximum temperature in Melbourne (state capital of Victoria, population 4 million people) exceeded 46 °C, there were wind gusts of over 80 km h(-1) and the relative humidity drop... | 25,172,086 | [
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A study of the reliability of the Nociception Coma Scale. | In this study, we investigated the reliability of the Nociception Coma Scale which has recently been developed to assess nociception in non-communicative, severely brain-injured patients. Prospective cross-sequential study. Semi-intensive care unit and long-term brain injury care. Forty-four patients diagnosed as being... | 25,172,088 | [
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Diversified bioactivities of four types of naturally occurring quinochalcones. | Quinochalcones, quinone-containing chalcones, belong to the flavonoid family and have attracted increasing popularity in Western countries in the last decade due to their pharmacological activities. This review describes four types of naturally occurring quinochalcones and summarizes their different pharmacological act... | 25,172,102 | [
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The apparent prevalence of skin lesions suspected to be human-inflicted in Danish finishing pigs at slaughter. | Skin lesions on pigs inflicted by humans compromise animal welfare and are the subject of increased public and political attention in Denmark. Systematic surveillance of such skin lesions was enforced in April 2010 at all Danish pig abattoirs, through the recording of meat inspection Code 904 for the presence of skin l... | 25,172,120 | [
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Development of (18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography. | Positron emission tomography (PET) is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases. PET uses biomolecules as probes which are labeled with radionuclides of short half-lives, synthesized prior to the imaging studies. These p... | 25,172,118 | [
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Synthesis of α-L-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibodies. | An α-L-rhamnosyl ceramide (1, α-L-RhaCer) has been prepared that was recognized by anti-L-rhamnose (anti-Rha) antibodies. During these studies we explored the use of an α-L-rhamnosyl thioglycoside and a trichloroacetimidate as a glycosyl donors. Subsequently, the acceptors desired for glycosylation, 3-O-benzoylazidosph... | 25,172,148 | [
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Novel chromogenic aminopeptidase substrates for the detection and identification of clinically important microorganisms. | A series of amino acid derivatives 8-10, 42 and 43 have been prepared as chromogenic enzyme substrates in order to detect aminopeptidase activity in clinically important Gram-negative and Gram-positive bacteria. Enzymatic hydrolysis liberates the amino acid moiety and either a 4-aminophenol or a 4-dialkylaminoaniline d... | 25,172,150 | [
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Analyzing cardiac rhythm in the presence of chest compression artifact for automated shock advisory. | Defibrillation is often required to terminate a ventricular fibrillation or fast ventricular tachycardia rhythm and resume a perfusing rhythm in sudden cardiac arrest patients. Automated external defibrillators rely on automatic ECG analysis algorithms to detect the presence of shockable rhythms before advising the res... | 25,172,189 | [
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Long-term clinical and radiological improvement of chronic acquired hepatocerebral degeneration after obliteration of portosystemic shunt: Report of a case. | Neurological manifestations are common in patients with decompensated cirrhosis. The majority of these patients show hepatic encephalopathy or chronic acquired (non-Wilsonian) hepatocerebral degeneration (CAHD). They characteristically present with dysarthria, ataxia, involuntary movements, and altered mental status. N... | 25,172,193 | [
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Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis. | Multiple sclerosis (MS) is an autoimmune-mediated inflammatory and debilitating disease of the central nervous system. Several investigations have suggested that the mitochondrial DNA encoded subunits of complex I gene variations are involved in the progression of MS. In this study, we investigated the possible associa... | 25,172,194 | [
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Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals. | Mitochondria play multiple roles in the maintenance of neuronal function under physiological and pathological conditions. In addition to ATP generation, they can act as major short-term calcium sinks and can both generate, and be damaged by, reactive oxygen species. Two complementary preparations have been extensively ... | 25,172,197 | [
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Decoupling function and anatomy in atlases of functional connectivity patterns: language mapping in tumor patients. | In this paper we construct an atlas that summarizes functional connectivity characteristics of a cognitive process from a population of individuals. The atlas encodes functional connectivity structure in a low-dimensional embedding space that is derived from a diffusion process on a graph that represents correlations o... | 25,172,207 | [
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Small amounts of functional ATP7A protein permit mild phenotype. | Mutations in ATP7A lead to at least three allelic disorders: Menkes disease (MD), Occipital horn syndrome and X-linked distal motor neuropathy. These disorders are mainly seen in male individuals, but a few affected females have been described. More than 400 different mutations have been identified in the ATP7A gene. W... | 25,172,213 | [
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Prediction of 3-dimensional pharyngeal airway changes after orthognathic surgery: a preliminary study. | Recent studies have shown some contradictory results when evaluating the consequences of orthodontic-surgical treatments on the pharyngeal airway. Therefore, the purpose of this study was to correlate the amount of jaw displacement with the volume variation and the minimal cross-sectional area of the pharyngeal airway.... | 25,172,252 | [
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Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004-2009. | The examination of lung cancer by histology type is important for monitoring population trends that have implications for etiology and prevention, screening and clinical diagnosis, prognosis and treatment. We provide a comprehensive description of recent histologic lung cancer incidence rates and trends in the USA usin... | 25,172,266 | [
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Restrictive symptomatic inclusion criteria create barriers to clinical research in schizophrenia negative symptoms: an analysis of the CATIE dataset. | Persistent negative symptoms are an important area of clinical research. However, there is limited consensus on how to define positive and negative symptom severity thresholds for inclusion in clinical trials. From the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset we evaluated the performa... | 25,172,269 | [
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Brain areas that influence general anesthesia. | This document reviews the literature on local brain manipulation of general anesthesia in animals, focusing on behavioral and electrographic effects related to hypnosis or loss of consciousness. Local inactivation or lesion of wake-active areas, such as locus coeruleus, dorsal raphe, pedunculopontine tegmental nucleus,... | 25,172,271 | [
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Gene inactivation in Coxiella burnetii. | Coxiella burnetii, the agent of human Q fever, is a zoonotic bacterial pathogen with a worldwide distribution. Owing to an historic lack of methods for genetic manipulation, virulence factors deployed by this bacterium for disease pathogenesis are poorly understood. However, the recent advance of host cell-free (axenic... | 25,172,290 | [
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A phase II study of S-1 chemotherapy with concurrent thoracic radiotherapy in elderly patients with locally advanced non-small-cell lung cancer: the Okayama Lung Cancer Study Group Trial 0801. | Although thoracic irradiation (TRT) is a standard treatment for elderly patients with locally advanced non-small-cell lung cancer (LA-NSCLC), treatment outcomes are poor. We previously reported a phase I trial combining S-1, an oral 5-fluorouracil derivative, and thoracic radiation, which yielded safe and effective out... | 25,172,295 | [
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Silver and fullerene nanoparticles' effect on interleukin-2-dependent proliferation of CD4 (+) T cells. | Immunotoxicity studies of nanoparticles on T cells addressed their effects on activation by T antigen receptor, but have neglected the regulation of proliferation by IL-2. In this study, the IL-2-dependent T lymphoblastoid WE17/10 cell line was used to compare silver (Ag-NPs) and fullerene (C60-NPs) nanoparticles' toxi... | 25,172,299 | [
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Intermittent whole-body cold immersion induces similar thermal stress but different motor and cognitive responses between males and females. | The main aim of this study was to compare the thermal responses and the responses of cognitive and motor functions to intermittent cold stress between males and females. The intermittent cold stress continued until rectal temperature (TRE) reached 35.5°C or for a maximum of 170 min. Thermal response and motor and cogni... | 25,172,303 | [
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Energy expenditure at work in physical education teachers. | The objective of this study was to quantify work energy expenditure (EE) in physical education (PE) teachers. Sixty-four (64) physical educators (49 men, 15 women) had their individualized linear function between heart rate (HR) and oxygen consumption measured by laboratory testing. HR was then recorded on 2 different ... | 25,172,305 | [
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Frontal theta activity is pronounced during illusory perception. | Object perception is driven by sensory information as well as expectations and prior experiences. The latter influence may increase when the sensory information is poor or inconclusive. Visual illusions, for example induced by ambiguous stimuli, provide a tool to investigate perceptual uncertainty, because ambiguous st... | 25,172,312 | [
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Neural transposition in the Drosophila brain: is it all bad news? | Transposition of mobile genetic elements can radically alter genome structure and sequence. In doing so, they can alter gene expression and cellular function. Perhaps unsurprisingly, this potentially catastrophic process is heavily constrained, especially in the germ line where aberrations lead to sterility or could be... | 25,172,346 | [
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-0.1456581... |
MicroRNAs in respiratory disease. A clinician's overview. | Since their initial discovery in the early 1990s, microRNAs have now become the focus of a multitude of lines of investigation ranging from basic biology to translational applications in the clinic. Previously believed to be of no biological relevance, microRNAs regulate processes fundamental to human health and diseas... | 25,172,373 | [
-0.1174007,
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0.154588,
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0.1329768,
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0.1428888,
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0.01605862,
-0.1484994,
0.1231606,
0.06553967,
0.01900721,
-0.294736,
... |
Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats. | Obesity increases the risk for cardiomyopathy in the absence of comorbidities. Myocardial structure is modified by dietary fatty acids. Left ventricular hypertrophy is associated with Western (WES) diet consumption, whereas intake of n-3 polyunsaturated fatty acids is associated with antihypertrophic effects. We previo... | 25,172,377 | [
-0.190792,
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0.5039716,
0.2506835,
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0.1794081,
-0.2934516,
0.4605089,
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-0... |
Evidence of degraded BMD and geometry at the proximal femora in male patients with alcoholic liver cirrhosis. | We examined the association of alcoholic cirrhosis in 33 patients with areal bone mineral density (BMD) and the assessed bone geometric strength of their proximal femora. Lower areal BMD, cross-sectional area and section modulus, thinner cortex, and higher buckling ratio suggest that the alcoholic liver cirrhosis is as... | 25,172,381 | [
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... |
Bone density is normal and does not change over 2 years in sarcoidosis. | Small studies have previously suggested that sarcoidosis may be associated with low bone mineral density. In this observational study of 64 patients with sarcoidosis, bone mineral density was within the normal range at baseline, and there was no evidence of accelerated bone loss over 1-2 years. Several small studies ha... | 25,172,384 | [
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0.313354,
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The time course of spoken word recognition in Mandarin Chinese: a unimodal ERP study. | In the present study, two experiments were carried out to investigate the time course of spoken word recognition in Mandarin Chinese using both event-related potentials (ERPs) and behavioral measures. To address the hypothesis that there is an early phonological processing stage independent of semantics during spoken w... | 25,172,388 | [
-0.1017658,
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0.0808172,
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0.1780859,
0.1784918,
0.02383518,
-0.1... |
Reconsideration of the WHO NCTB strategy and test selection. | The World Health Organization-recommended neurobehavioral core test battery (NCTB) became the international standard for identifying adverse human behavioral effects due to neurotoxic chemical exposure when it was first proposed in 1983. Since then the WHO NCTB has been repeatedly cited as the basis for test selection ... | 25,172,409 | [
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0.263388,
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0.2090941,
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0.8073907,
-0.0410349... |
Assessment of repeatability of hyperpolarized gas MR ventilation functional imaging in cystic fibrosis. | Hyperpolarized (HP) gas magnetic resonance imaging (MRI) is an advanced imaging technique that provides high-resolution regional information on lung function without using ionizing radiation. Before this modality can be considered for assessing clinical or investigational interventions, baseline repeatability needs to ... | 25,172,411 | [
-0.07081714,
0.2569768,
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0.03628996,
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0.1468946,
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0.3028403,
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0.1344467,
-0.0247... |
Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer. | A novel synthesis of the translocator protein (TSPO) ligand 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575, 3) was achieved in four steps from commercially available starting materials. Focused structure-activity relationship development about the pyridazinoindole ... | 25,172,419 | [
-0.2759367,
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0.1210286,
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0.5308872,
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0.2123802,
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0.3605221,
-0.0496532... |
Design, synthesis and molecular modeling of biquinoline-pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors. | A new series of biquinoline-pyridine hybrids were designed and synthesized by a base-catalyzed cyclocondensation through one-pot multicomponent reaction. All compounds were tested for in vitro anticancer activities against two cancer cell lines A549 (adenocarcinomic human alveolar basal epithelial) and Hep G2 (liver ca... | 25,172,421 | [
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0.1629532,
0.09077397,
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0.1228741,
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0.1025323,
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0.1717236,
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0.1848998,
0.1042753,
0.009551947... |
AHNAK: the giant jack of all trades. | The nucleoprotein AHNAK is an unusual and somewhat mysterious scaffolding protein characterised by its large size of approximately 700 kDa. Several aspects of this protein remain uncertain, including its exact molecular function and regulation on both the gene and protein levels. Various studies have attempted to annot... | 25,172,424 | [
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-0.4726049,
-0.09476473,
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0.03080003,
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-0.06470828,
-0.00729989,
-0.03148086,
0.0357973,
0.1193129,
-0.205044... |
Comparison of personality beliefs between depressed patients and healthy controls. | According to the cognitive model, the common mechanism underlying all psychological disorders is distorted or dysfunctional thoughts that affect mood and behaviors. Dysfunctional thoughts predispose an individual to depression and are among the processes that form the basis of personality traits. Elucidating the person... | 25,172,443 | [
-0.1477829,
0.06434473,
-0.04076757,
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0.2108744,
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0.02884777,
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0.1487631,
0.06422891,
0.1942679,
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0.291473,
0.07539944,
0.06914068,
0.1754294,
0.1366198,
-0.115352,
... |
In silico analysis of L-asparaginase from different source organisms. | L-asparaginases are widely distributed enzymes among plants, fungi and bacteria. This enzyme catalyzes the conversion of l-asparagine to l-aspartate and ammonia and to a lesser extent the formation of l-glutamate from l-glutamine. In the present study, forty-five full-length amino acid sequences of L-asparaginases from... | 25,172,447 | [
0.09735632,
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0.2449398,
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0.09712546,
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0.1425006,
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0.3387646,
0.1832224,
0.01025176,
0.09649391,
0.5573816,
0.07636496,
... |
Whole genome phylogeny of Prochlorococcus marinus group of cyanobacteria: genome alignment and overlapping gene approach. | Prochlorococcus is the smallest known oxygenic phototrophic marine cyanobacterium dominating the mid-latitude oceans. Physiologically and genetically distinct P. marinus isolates from many oceans in the world were assigned two different groups, a tightly clustered high-light (HL)-adapted and a divergent low-light (LL-)... | 25,172,453 | [
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0.04699154,
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0.0606944,
0.0733834,
0.3198432,
0.1506746,
-0.1145371,
... |
Acid-activated biochar increased sulfamethazine retention in soils. | Sulfamethazine (SMZ) is an ionizable and highly mobile antibiotic which is frequently found in soil and water environments. We investigated the sorption of SMZ onto soils amended with biochars (BCs) at varying pH and contact time. Invasive plants were pyrolyzed at 700 °C and were further activated with 30 % sulfuric (S... | 25,172,460 | [
-0.06949156,
0.1722303,
0.2455368,
0.1406304,
0.1123199,
0.3620694,
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0.06455693,
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0.09180596,
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0.1494136,
0.1281583,
-0.09157606,
0.3427137,
0.424913,
0.2288463,
-0.17... |
Thallium and potassium uptake kinetics and competition differ between durum wheat and canola. | Thallium (Tl) is very toxic to mammals but little is known about its accumulation by plants, and it would be useful if prediction of Tl accumulation could be done using potassium (K) accumulation models. The objectives of this study were to compare the uptake kinetics of Tl(+) and K(+), and to determine how readily K(+... | 25,172,467 | [
-0.1563825,
0.01266283,
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0.005906109,
0.1435253,
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0.369702,
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0.4910674,
0.6898744,
0.2099051,
... |
Notch signaling at later stages of NK cell development enhances KIR expression and functional maturation. | The Notch signaling pathway plays a substantial role in human NK cell development. However, the role of Notch on killer Ig-like receptor (KIR) upregulation and acquisition of effector function has not been explored. To evaluate how Notch influences terminal differentiation, cord blood-derived NK cells or sorted periphe... | 25,172,483 | [
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0.03594385,
0.4727603,
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0.07390271,
0.... |
Assembly of telomeric chromatin to create ALTernative endings. | Circumvention of the telomere length-dependent mechanisms that control the upper boundaries of cellular proliferation is necessary for the unlimited growth of cancer. Most cancer cells achieve cellular immortality by up-regulating the expression of telomerase to extend and maintain their telomere length. However, a sma... | 25,172,551 | [
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0.08092926,
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0.05607802,
0.01567032,
-0.01052588,
0.2594202,
0.1582399,
-0.240875... |
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