title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Factors and Trends Affecting the Identification of a Reliable Biomarker for Diesel Exhaust Exposure. | The monitoring of human exposures to diesel exhaust continues to be a vexing problem for specialists seeking information on the potential health effects of this ubiquitous combustion product. Exposure biomarkers have yielded a potential solution to this problem by providing a direct measure of an individual's contact w... | 25,170,242 | [
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Safety and efficacy of fixed-combination travoprost/timolol in patients with open-angle glaucoma or ocular hypertension not controlled with timolol monotherapy. | To assess the intraocular pressure (IOP)-lowering effect of travoprost 0.004%/timolol 0.5% fixed-dose combination (TRAV/TIM-FC) in patients not achieving the target IOP of ≤18 mmHg while on timolol 0.5% (TIM) monotherapy. A multicenter, prospective, open-label study (NCT01336569) was conducted in patients with open-ang... | 25,170,245 | [
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Advanced prostate cancer - patient survival and potential impact of enzalutamide and other emerging therapies. | The advent of exponential growth of novel agents tested and approved for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) has brought about a need for understanding of the mechanism of action, side-effects, and clinical efficacy of these drugs as they relate to these patients. This... | 25,170,270 | [
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Profile of pacritinib and its potential in the treatment of hematologic disorders. | Pacritinib (previously known as SB-1518) is an innovative selective inhibitor of Janus kinase 2 and FMS-related tyrosine kinase 3 providing potential in the treatment of hematological malignancies such as myeloproliferative neoplasias, acute myeloid leukemia, and various lymphomas. Pacritinib has potent antiproliferati... | 25,170,285 | [
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AKR1C3 overexpression mediates methotrexate resistance in choriocarcinoma cells. | Chemotherapy is typically used to treat choriocarcinoma, but a small proportion of tumors develop resistance to chemotherapy. Similarly, methotrexate (MTX) is a first-line chemotherapy used to treat choriocarcinoma; although ~30% of patients are drug-resistant for MTX mono-therapy. Thus, we sought to elucidate the mech... | 25,170,291 | [
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Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice. | MUTYH is a DNA glycosylase that excises adenine paired with 8-oxoguanine to prevent mutagenesis in mammals. Biallelic germline mutations of MUTYH have been found in patients predisposed to a recessive form of familial adenomatous polyposis (MAP: MUTYH-associated polyposis). We previously reported that Mutyh-deficient m... | 25,170,306 | [
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Out-diffused silver island films for surface-enhanced Raman scattering protected with TiO2 films using atomic layer deposition. | We fabricated self-assembled silver nanoisland films using a recently developed technique based on out-diffusion of silver from an ion-exchanged glass substrate in reducing atmosphere. We demonstrate that the position of the surface plasmon resonance of the films depends on the conditions of the film growth. The resona... | 25,170,333 | [
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E-cigarettes: online survey of UK smoking cessation practitioners. | Use of e-cigarettes (inhalable vapour producing battery powered devices that aim to simulate tobacco cigarettes), is rising in a number of countries, but as yet none of these products are regulated as medicinal devices or available as smoking cessation treatments. Smokers seeking support from health professionals to st... | 25,170,337 | [
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Increasing sexually transmitted infection rates in young men having sex with men in the Netherlands, 2006-2012. | Men having sex with men (MSM) remain the largest high-risk group involved in on-going transmission of sexually transmitted infections (STI), including HIV, in the Netherlands. As risk behaviour may change with age, it is important to explore potential heterogeneity in risks by age. To improve our understanding of this ... | 25,170,341 | [
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Copy number variation in Han Chinese individuals with autism spectrum disorder. | Autism spectrum disorders (ASDs) are a group of neurodevelopmental conditions with a demonstrated genetic etiology. Rare (<1% frequency) copy number variations (CNVs) account for a proportion of the genetic events involved, but the contribution of these events in non-European ASD populations has not been well studie... | 25,170,348 | [
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Prevalence of erectile dysfunction and associated factors among diabetic men attending diabetic clinic at Muhimbili National Hospital in Dar-es-Salaam, Tanzania. | There has been an increase in the prevalence of erectile dysfunction (ED) in the general population especially among Diabetic patients. This seems to be neglected problem in low-income countries. This study aims at establishing the prevalence of ED and associated risk factors in diabetic patients attended at Diabetic C... | 25,170,371 | [
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Stromal tumor of the lesser omentum : a case report. | Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen. Extragastrointestinal stromal tumors (EGISTs), neoplasms with immunohistological features ... | 25,170,380 | [
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Adherence to antiretroviral therapy among HIV-infected children receiving care at Kilimanjaro Christian Medical Centre (KCMC), Northern Tanzania: A cross- sectional analytical study. | Paediatric adherence to Highly Active Antiretroviral Therapy (HAART) is a dynamic process involving many factors. Adherence for the majority on therapy matters to prevent failure of 1(st) and 2(st) line therapy. The purpose of this study was to determine the rate of adherence to antiretroviral therapy in HIV infected c... | 25,170,382 | [
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Gastrointestinal imaging-practical magnetic resonance imaging approach. | Over the past two decades, advances in cross-sectional imaging such as computed tomography and magnetic resonance imaging (MRI) have dramatically changed the concept of gastrointestinal imaging. MR is playing an increasing role in the evaluation of gastrointestinal disorders. MRI combines the advantages of excellent so... | 25,170,393 | [
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Characterization of ureteral stents by dual-energy computed tomography: Clinical implications. | Dual-energy computed-tomography (DECT) has been suggested as the method of choice for imaging urinary calculi due to the modality's high sensitivity for detecting stones and its capability of accurately differentiating between uric-acid (UA) and non-UA (predominantly calcium) stones. The clinical significance of the la... | 25,170,401 | [
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Predictors of reintubation in trauma intensive care unit: qatar experience. | To determine the causes, predictors and outcomes of re-intubation. Retrospective analysis of data collected from the trauma data base registry was conducted to identify the extubation failure cases in Trauma ICU at Hamad General Hospital, the only Level I trauma center in Qatar between January 2009 and December 2010. D... | 25,170,412 | [
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Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line. | Previously, we demonstrated the sensitivity of RPTEC/TERT1 cells, an immortalized human renal proximal tubule epithelial cell line, to two common environmental carcinogens, cadmium (Cd) and benzo[a]pyrene (B[a]P). Here, we measured BPDE-DNA adducts using a competitive ELISA method after cells were exposed to 0.01, 0.1,... | 25,170,436 | [
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Binge drinking and psychoactive drug use in a cohort of European youths. | TEN-D by Night is an international, multicentre, cross-sectional portal survey conducted on a large sample of young people in six European countries. This paper aims to investigate the alcohol and psychoactive drug consumption of this sample, with a focus on the prevalence of binge drinking and the poly-drug habits of ... | 25,170,451 | [
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Talking About Sex in Malawi: Toward a Better Understanding of Interpersonal Communication for HIV Prevention. | The generalised AIDS epidemic in Malawi presents many challenges. As communication and advice from parents, peers, and partners are important factors in influencing sexual behaviour, understanding communication may provide insights into behaviour change programming. This mixed-method study used a household survey (n=18... | 25,170,453 | [
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What is Behind the Seeming Cessation of the Increase in Sleep Medicine Consumption in Finland During the Last Years? | In Finland, between 2003 and 2010 and parallel to the increase in the prevalence of insomnia-related symptoms among the general population, there has been a cessation of growth and even a decrease in the consumption of traditional hypnotics. The reasons behind this seemingly paradoxical situation are not known. We anal... | 25,170,458 | [
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Tuberculosis in quebec: a review of trends. | The aim of this research was to conduct a thorough review on the literature of tuberculosis in Canada and the Province of Quebec. To achieve this aim, an exhaustive literature review of tuberculosis in the Province of Quebec was undertaken. Data was collected with the goal of creating an epidemiological and public heal... | 25,170,460 | [
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Prevalence of vitamin d insufficiency in qatar: a systematic review. | Qatar has a high burden of chronic diseases including obesity, cardiovascular disease and type 2 diabetes mellitus. Low serum vitamin D levels have been implicated in the development and progression of a range of these chronic conditions. The prevalence of vitamin D insufficiency or deficiency in the general population... | 25,170,469 | [
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The crisis of capitalism and the marketisation of health care: the implications for public health professionals. | The current economic crisis in Europe has challenged the basis of the economic model that currently prevails in much of the industrialised world. It has revealed a system that is managed not for the benefit of the people but rather for the corporations and the small elite who lead them, and which is clearly unsustainab... | 25,170,470 | [
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Intermittent attendance at breast cancer screening. | To determine why women skip rounds and factors influencing return of previous non attenders (PNAs) to breast screening. Retrospective, quantitative, structured questionnaire posted to 2500 women. First PNAs did not attend their first screening appointment in 2007/2008 but then attended in 2010; First Controls first att... | 25,170,485 | [
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Crisis Communication in the Area of Risk Management: The CriCoRM Project. | During the last H1N1 pandemic has emerged the importance of crisis communication as an essential part of health crisis management. The Project aims specifically to improve the understanding of crisis communication dynamics and effective tools and to allow public health institutions to communicate better with the public... | 25,170,491 | [
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Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset. | The common marmoset (Callithrix jacchus) is increasingly being utilised as a nonhuman primate model for human disease, ranging from autoimmune to infectious disease. In order to fully exploit these models, meaningful comparison to the human host response is necessary. Commercially available reagents, primarily targeted... | 25,170,519 | [
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Roughness in lattice ordered effect algebras. | Many authors have studied roughness on various algebraic systems. In this paper, we consider a lattice ordered effect algebra and discuss its roughness in this context. Moreover, we introduce the notions of the interior and the closure of a subset and give some of their properties in effect algebras. Finally, we use a ... | 25,170,523 | [
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Can primary failure of arteriovenous fistulas be anticipated? | Primary failure, early thrombosis, and inadequate maturation are the main complications encountered in arteriovenous fistulas. Doppler ultrasonographic assessment of flow-mediated dilatation (FMD) is currently used for the early diagnosis of atherosclerosis. Clinical experience in the use of FMD for preoperative assess... | 25,170,532 | [
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Evaluation of serum perforin, caspase-3, sFasL and M-30 levels as apoptotic markers in children with Crimean-Congo hemorrhagic fever. | Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the lev... | 25,170,551 | [
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From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination. | A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman's chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields rangi... | 25,170,560 | [
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Identification of species and geographical strains of Sitophilus oryzae and Sitophilus zeamais using the visible/near-infrared hyperspectral imaging technique. | Identifying stored-product insects is essential for granary management. Automated, computer-based classification methods are rapidly developing in many areas. A hyperspectral imaging technique could potentially be developed to identify stored-product insect species and geographical strains. This study tested and adapte... | 25,170,577 | [
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Anti-vascular endothelial growth factor for neovascular age-related macular degeneration. | Age-related macular degeneration (AMD) is the most common cause of uncorrectable severe vision loss in people aged 55 years and older in the developed world. Choroidal neovascularization (CNV) secondary to neovascular AMD accounts for most AMD-related severe vision loss. Anti-vascular endothelial growth factor (anti-VE... | 25,170,575 | [
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Functional hyperbranched polymers with advanced optical, electrical and magnetic properties. | As one kind of important functional material, those with advanced optical, electrical and magnetic characteristics have attracted increasing attention due to their essential and irreplaceable role in the daily life of humans. In particular, optical, electrical and magnetic hyperbranched polymers (HBPs) exhibit some uni... | 25,170,592 | [
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Maintaining tissue selenium species distribution as a potential defense mechanism against methylmercury toxicity in juvenile white sturgeon (Acipenser transmontanus). | Selenium (Se) has been shown to antagonize mercury (Hg) toxicity. We have previously demonstrated that orally intubated selenomethionine (SeMet) and methylmercury (MeHg) reduced tissue Se accumulation, as well as blood and kidney Hg concentrations in juvenile white sturgeon (Acipenser transmontanus). However, the form ... | 25,170,596 | [
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Doxorubicin-loaded magnetic gold nanoshells for a combination therapy of hyperthermia and drug delivery. | In the present work, nanohybrid of an anticancer drug, doxorubicin (Dox) loaded gold-coated superparamagnetic iron oxide nanoparticles (SPIONs@Au) were prepared for a combination therapy of cancer by means of both hyperthermia and drug delivery. The Dox molecules were conjugated to SPIONs@Au nanoparticles with the help... | 25,170,601 | [
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First-trimester screening for down syndrome with serum sampling at different gestational ages: the effect on screening performance. | The objective of this study was to evaluate the performance of first-trimester Down syndrome (DS) screening with serum sampling at different weeks of gestation. We studied 35,431 singleton pregnancies (2005-2011), including 145 DS cases. Screening performance was determined in different maternal age groups with serum s... | 25,170,623 | [
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Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer. | We performed Escherichia coli ampicillin secretion trap (CAST) analysis in prostate cancer (PCa) to identify novel biomarkers. We show here that OPHN1, which encodes oligophrenin-1 protein, is upregulated in PCa. OPHN1 was first determined to be one of the genes associated with X-linked mental retardation; however, nei... | 25,170,626 | [
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Multicenter ALK testing in non-small-cell lung cancer: results of a round robin test. | The anaplastic lymphoma kinase (ALK) inhibitor crizotinib has recently received approval for the treatment of patients with locally advanced or metastatic ALK-positive non-small-cell lung cancer (NSCLC). As the therapeutic prescription postulates the detection of ALK rearrangements, reliable diagnostic approaches are o... | 25,170,635 | [
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Noninvasive risk stratification of lung adenocarcinoma using quantitative computed tomography. | Lung cancer remains the leading cause of cancer-related deaths in the United States and worldwide. Adenocarcinoma is the most common type of lung cancer and encompasses lesions with widely variable clinical outcomes. In the absence of noninvasive risk stratification, individualized patient management remains challengin... | 25,170,645 | [
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Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture. | The aim of this study was to evaluate local control (LC) and the risk of vertebral compression fracture (VCF) after stereotactic body radiotherapy (SBRT) in patients with renal cell cancer spinal metastases. Prospectively collected data on 71 spinal segments treated with SBRT in 37 patients were reviewed. The median fo... | 25,170,656 | [
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Steering matter wave superradiance with an ultranarrow-band optical cavity. | A superfluid atomic gas is prepared inside an optical resonator with an ultranarrow bandwidth on the order of the single photon recoil energy. When a monochromatic off-resonant laser beam irradiates the atoms, above a critical intensity the cavity emits superradiant light pulses with a duration on the order of its phot... | 25,170,694 | [
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Modeling nanoscale inhomogeneities for quantitative HAADF STEM imaging. | High-angle annular dark-field scanning transmission electron microscopy in conjunction with image simulation is an important tool to determine the structure of nanomaterials. We show that molecular dynamics calculations can be combined with multislice image simulations to account for the large effects of surface-enhanc... | 25,170,712 | [
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Breaking the theoretical scaling limit for predicting quasiparticle energies: the stochastic GW approach. | We develop a formalism to calculate the quasiparticle energy within the GW many-body perturbation correction to the density functional theory. The occupied and virtual orbitals of the Kohn-Sham Hamiltonian are replaced by stochastic orbitals used to evaluate the Green function G, the polarization potential W, and, ther... | 25,170,715 | [
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Non-Fermi-liquid manifold in a Majorana device. | We propose and study a setup realizing a stable manifold of non-Fermi-liquid states. The device consists of a mesoscopic superconducting island hosting N≥3 Majorana bound states tunnel coupled to normal leads, with a Josephson contact to a bulk superconductor. We find a nontrivial interplay between multichannel Kondo a... | 25,170,717 | [
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Cooling a magnetic nanoisland by spin-polarized currents. | We investigate cooling of a vibrational mode of a magnetic quantum dot by a spin-polarized tunneling charge current exploiting the magnetomechanical coupling. The spin-polarized current polarizes the magnetic nanoisland, thereby lowering its magnetic energy. At the same time, Ohmic heating increases the vibrational ene... | 25,170,723 | [
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Accurate predictions of C-SO2R bond dissociation enthalpies using density functional theory methods. | The dissociation of the C-SO2R bond is frequently involved in organic and bio-organic reactions, and the C-SO2R bond dissociation enthalpies (BDEs) are potentially important for understanding the related mechanisms. The primary goal of the present study is to provide a reliable calculation method to predict the differe... | 25,170,742 | [
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The merits of unconscious thought in rule detection. | According to unconscious thought theory (UTT), unconscious thought is more adept at complex decision-making than is conscious thought. Related research has mainly focused on the complexity of decision-making tasks as determined by the amount of information provided. However, the complexity of the rules generating this ... | 25,170,756 | [
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Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells--possible relevance to autism spectrum disorders. | Alterations in gut microbiome composition have an emerging role in health and disease including brain function and behavior. Short chain fatty acids (SCFA) like propionic (PPA), and butyric acid (BA), which are present in diet and are fermentation products of many gastrointestinal bacteria, are showing increasing impor... | 25,170,769 | [
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A non-neuronal cholinergic system regulates cellular ATP levels to maintain cell viability. | We previously suggested that a non-neuronal cholinergic system modulates energy metabolism through the mitochondria. However, the mechanisms responsible for making this system crucial remained undetermined. In this study, we developed a fusion protein expression vector containing a luciferase gene fused to the folic ac... | 25,170,772 | [
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Clinical implications of local field potentials for understanding and treating movement disorders. | Deep brain stimulation (DBS) for the treatment of movement disorders has provided researchers with an opportunity to record electrical oscillatory activity from electrodes implanted in deep brain structures. Extracellular activity recorded from a population of neurons, termed local field potentials (LFPs), has shed lig... | 25,170,784 | [
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Homogeneous hydrogenation of CO₂ to methyl formate utilizing switchable ionic liquids. | Combined capture of CO2 and subsequent hydrogenation allows for base/methanol-promoted homogeneous hydrogenation of CO2 to methyl formate. The CO2, captured as an amidinium methyl carbonate, reacts with H2 with no applied pressure of CO2 in the presence of a catalyst to produce sequentially amidinium formate, then meth... | 25,170,785 | [
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Cognitive control predicts use of model-based reinforcement learning. | Accounts of decision-making and its neural substrates have long posited the operation of separate, competing valuation systems in the control of choice behavior. Recent theoretical and experimental work suggest that this classic distinction between behaviorally and neurally dissociable systems for habitual and goal-dir... | 25,170,791 | [
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Correlation between leucine rich domain and the stability of LRWD1 protein in human NT2/D1 cells. | LRWD1 is a protein that contains LRR and WDs domains and is important in regulating spermatogenesis. However, the roles of LRR or WDs domains in the expression of LRWD1 remain unclear. The NT2/D1 cells separately transfected with full length of LRWD1 gene (LRWD(WT)) or genes with deleted sequences in the LRR domain (LR... | 25,170,821 | [
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Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression. | Among various phytochemicals, coumarins comprise a very large class of plant phenolic compounds that have good nutritive value, in addition to their antioxidant effects. The purpose of the present study was to investigate the protective effects of two coumarin derivatives, umbelliferone and daphnetin, against carbon te... | 25,170,823 | [
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Evaluation of an automated rapid diagnostic test for detection of Clostridium difficile. | The Verigene Clostridium difficile Nucleic Acid Test (Verigene CDF Test) (Nanosphere, Northbrook, IL, USA) is a new multiplex qualitative polymerase chain reaction (PCR) test used to detect C. difficile toxin genes in fecal specimens. To evaluate the performance of the new method, we tested 69 fecal samples from patien... | 25,170,836 | [
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... |
Response of schizophrenic patients to dynamic facial expressions: an event-related potentials study. | Patients with schizophrenia have an impaired ability to respond to faces and may specifically show an impaired response to dynamic facial expressions. Here we investigated the responses of schizophrenic patients and healthy controls to dynamic facial images using event-related potentials (ERPs). We showed 13 schizophre... | 25,170,847 | [
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Prenatal Diagnosis of Congenital Absence of Aortic Valve: A Report of Two Cases with Different Outcomes and a Literature Review. | Congenital absence of aortic valve (AAV) is a rare cardiac anomaly associated with high mortality. We present 2 prenatally diagnosed cases of AAV. In both cases, fetal echocardiography showed no aortic valve tissue and free aortic regurgitation. At 24 weeks' gestation, case 1 showed a hypoplastic hypocontractile left v... | 25,170,850 | [
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Effectiveness and complications of ultrasound guided fine needle aspiration for primary liver cancer in a Chinese population with serum α-fetoprotein levels ≤200 ng/ml--a study based on 4,312 patients. | Hepatocellular carcinoma (HCC) can be diagnosed by noninvasive approaches with serum α-fetoprotein (AFP) levels >200 ng/ml and/or a radiological imaging study of tumor mass >2 cm in patients with chronic liver disease. Percutaneous fine needle aspiration (FNA) under ultrasound (US) guidance has a diagnostic speci... | 25,170,868 | [
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Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice. | We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-injected and KKAy obese diabetic mice. These mice were pair-fed three different types of diets, standard chow (SC, C∶P∶F = 63∶15∶22), a low carbohydrate (LC, C∶P∶F = 38∶25∶37) diet and a severely carbohydrate restricted (SR, C... | 25,170,869 | [
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Towards monitoring biodiversity in Amazonian forests: how regular samples capture meso-scale altitudinal variation in 25 km2 plots. | Ecological monitoring and sampling optima are context and location specific. Novel applications (e.g. biodiversity monitoring for environmental service payments) call for renewed efforts to establish reliable and robust monitoring in biodiversity rich areas. As there is little information on the distribution of biodive... | 25,170,894 | [
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L-carnitine reduces in human conjunctival epithelial cells hypertonic-induced shrinkage through interacting with TRPV1 channels. | Ocular surface health depends on conjunctival epithelial (HCjE) layer integrity since it protects against pathogenic infiltration and contributes to tissue hydration maintenance. As the same increases in tear film hyperosmolarity described in dry eye disease can increase corneal epithelial transient receptor potential ... | 25,170,901 | [
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Data mechanics and coupling geometry on binary bipartite networks. | We quantify the notion of pattern and formalize the process of pattern discovery under the framework of binary bipartite networks. Patterns of particular focus are interrelated global interactions between clusters on its row and column axes. A binary bipartite network is built into a thermodynamic system embracing all ... | 25,170,903 | [
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Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein. | Current therapies for most acute toxin exposures are limited to administration of polyclonal antitoxin serum. We have shown that VHH-based neutralizing agents (VNAs) consisting of two or more linked, toxin-neutralizing heavy-chain-only VH domains (VHHs), each binding distinct epitopes, can potently protect animals from... | 25,170,904 | [
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Individual- and neighborhood-level predictors of mortality in Florida colorectal cancer patients. | We examined individual-level and neighborhood-level predictors of mortality in CRC patients diagnosed in Florida to identify high-risk groups for targeted interventions. Demographic and clinical data from the Florida Cancer Data System registry (2007-2011) were linked with Agency for Health Care Administration and US C... | 25,170,910 | [
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Lectin-like oxidized LDL receptor-1 is an enhancer of tumor angiogenesis in human prostate cancer cells. | Altered expression and function of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been associated with several diseases such as endothelial dysfunction, atherosclerosis and obesity. In these pathologies, oxLDL/LOX-1 activates signaling pathways that promote cell proliferation, cell motility and ang... | 25,170,920 | [
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En bloc dual kidney transplantation from pediatric donors after cardiac death: initial experience in China. | To report 9 cases of en bloc kidney transplantation from pediatric donors in China and share the clinical experience. From February 2010 to February 2014, 9 pediatric donors (aged 5 months to 6 years) were assigned to us by the modern donation and allocation system after cardiac death. The en bloc kidneys were recovere... | 25,170,936 | [
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Evaluation of a modified Cefsulodin-Irgasan-Novobiocin agar for isolation of Yersinia spp. | Y. enterocolitica and Y. pseudotuberculosis are important food borne pathogens. However, the presence of competitive microbiota makes the isolation of Y. enterocolitica and Y. pseudotuberculosis from naturally contaminated foods difficult. We attempted to evaluate the performance of a modified Cefsulodin-Irgasan-Novobi... | 25,170,941 | [
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Three-dimensional flow of an Oldroyd-B nanofluid towards stretching surface with heat generation/absorption. | This article addresses the steady three-dimensional flow of an Oldroyd-B nanofluid over a bidirectional stretching surface with heat generation/absorption effects. Suitable similarity transformations are employed to reduce the governing partial differential equations into coupled nonlinear ordinary differential equatio... | 25,170,945 | [
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A comparative analysis of open surgery vs endoscopic balloon dilation for pediatric subglottic stenosis. | Minimally invasive endoscopic techniques are an appealing alternative to open surgical management of pediatric subglottic stenosis (SGS), but more information is needed to understand the comparative risks, benefits, and limitations of such interventions. To compare the effectiveness of endoscopic balloon dilation (EBD)... | 25,170,960 | [
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Quantum Monte Carlo for noncovalent interactions: an efficient protocol attaining benchmark accuracy. | Reliable theoretical prediction of noncovalent interaction energies, which are important e.g. in drug-design and hydrogen-storage applications, is one of the longstanding challenges of contemporary quantum chemistry. In this respect, the fixed-node diffusion Monte Carlo (FN-DMC) method is a promising alternative to the... | 25,170,978 | [
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Contrasting light spectra constrain the macro and microstructures of scleractinian corals. | The morphological plasticity of scleractinian corals can be influenced by numerous factors in their natural environment. However, it is difficult to identify in situ the relative influence of a single biotic or abiotic factor, due to potential interactions between them. Light is considered as a major factor affecting c... | 25,170,981 | [
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Anion radicals of isomeric [5,6] and [6,6] benzoadducts of Sc3N@C80: remarkable differences in endohedral cluster spin density and dynamics. | The anion radicals of isomeric [5,6] and [6,6] Sc3N@C80 benzoadducts were studied by electron spin resonance spectroscopy, density functional theory computations, and molecular dynamics. In both compounds the rotation of the Sc3N cluster is frozen and the spin density distribution of the cluster is highly anisotropic, ... | 25,170,987 | [
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Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2. | Fibroblast growth factor-2 (FGF-2) plays a critical role in endothelial survival, proliferation, and angiogenesis and is localized on the cell membrane by binding to heparan sulfate proteoglycans. Here we established a neutralizing monoclonal antibody, 1B9B9, against FGF-2 using the rat medial iliac lymph node method. ... | 25,171,006 | [
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Sensorimotor training during expression of the leg extension response (LER) in 1-day-old rats. | In newborn rats, the leg extension response (LER) is a coordinated hyperextension of the hindlimbs that is shown in response to anogenital stimulation. Here we examined the influence of sensorimotor training on LER expression in postnatal day 1 rats. In Experiment 1, we examined if proprioceptive feedback facilitates L... | 25,171,018 | [
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Common misdiagnoses of biliary atresia. | Discrimination of biliary atresia (BA) from other causes of neonatal cholestasis (NC) is challenging. We aimed to analyze the clinicopathological findings in cholestatic infants who were provisionally diagnosed with BA and then excluded by intraoperative cholangiography compared with those with a definitive diagnosis o... | 25,171,020 | [
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Color stability of shade guides after autoclave sterilization. | This study evaluated the influence of 120 autoclave sterilization cycles on the color stability of two commercial shade guides (Vita Classical and Vita System 3D-Master). The specimens were evaluated by spectrophotometer before and after the sterilization cycles. The color was described using the three-dimensional CIEL... | 25,171,040 | [
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Prospective observational study of the early loading of nanostructured calcium phosphate-coated tapered implants in the mandible and maxilla. | The purpose of this study was to evaluate the prospective clinical results of early loading. Implants were inserted in 11 maxillae (group I, 23 implants) and 12 mandibles (group II, 19 implants). Six months after prosthetic loading, several factors were investigated. Significant differences between the primary and seco... | 25,171,041 | [
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De novo design of functional oligonucleotides with acyclic scaffolds. | In this account, we demonstrate a new methodology for the de novo design of functional oligonucleotides with the acyclic scaffolds threoninol and serinol. Four functional motifs-wedge, interstrand-wedge, dimer, and cluster-have been prepared from natural DNA or RNA and functional base surrogates prepared from d-threoni... | 25,171,046 | [
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Literacy effects on language and vision: emergent effects from an amodal shared resource (ASR) computational model. | Learning to read and write requires an individual to connect additional orthographic representations to pre-existing mappings between phonological and semantic representations of words. Past empirical results suggest that the process of learning to read and write (at least in alphabetic languages) elicits changes in th... | 25,171,049 | [
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A comparative study of different aspects of manipulating ratio spectra applied for ternary mixtures: derivative spectrophotometry versus wavelet transform. | This work represents a comparative study of different aspects of manipulating ratio spectra, which are: double divisor ratio spectra derivative (DR-DD), area under curve of derivative ratio (DR-AUC) and its novel approach, namely area under the curve correction method (AUCCM) applied for overlapped spectra; successive ... | 25,171,050 | [
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Renal denervation using focused infrared fiber lasers: a potential treatment for hypertension. | Renal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal den... | 25,171,055 | [
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Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania (L.) infantum: biological activity and structure-activity relationships. | Naphtoquinones have been used as promising scaffolds for drug design studies against protozoan parasites. Considering the highly toxic and limited therapeutic arsenal, the global negligence with tropical diseases and the elevated prevalence of co-morbidities especially in developing countries, the parasitic diseases ca... | 25,171,058 | [
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0.07... |
Single tyrosine mutation in AAV8 vector capsid enhances gene lung delivery and does not alter lung morphofunction in mice. | Vectors derived from adeno-associated viruses (AAVs) are important gene delivery tools for treating pulmonary diseases. Phosphorylation of surface-exposed tyrosine residues from AAV2 capsid targets the viral particles for ubiquitination and proteasome-mediated degradation, and mutations of these tyrosine residues lead ... | 25,171,090 | [
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0.2650626,
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0.2207045,
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Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka. | Widespread environmental antiandrogen contamination has been associated with negative impacts on biodiversity and human health. In particular, many pesticides are antiandrogenic, creating a need for robust and sensitive environmental monitoring. Our aim was to develop a sensitive and specific transgenic medaka (Oryzias... | 25,171,099 | [
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0.3960001,
0.4946037,
0.4120748,
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Reduction of cardiac cell death after helium postconditioning in rats: transcriptional analysis of cell death and survival pathways. | Helium, a noble gas, has been used safely in humans. In animal models of regional myocardial ischemia/reperfusion (I/R) it was shown that helium conditioning reduces infarct size. Currently, it is not known how helium exerts its cytoprotective effects and which cell death/survival pathways are affected. The objective o... | 25,171,109 | [
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0.3153682,
0.1750253,... |
Use of selective serotonin-reuptake inhibitors during pregnancy and the risk of clubfoot. | Selective serotonin-reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. Previous studies have suggested that SSRIs may increase the risk of birth defects, including clubfoot. Using data from a population-based case-control study, we evaluated whether SSRI use increased the risk of clubfoot. Mo... | 25,171,134 | [
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... |
Siloxy alkynes in annulation reactions. | Siloxy alkynes are a family of versatile species in organic synthesis. This account reviews the annulation reactions of siloxy alkynes for the synthesis of a variety of carbo- and heterocyclic products. With various dipolarophiles or dipolarophile-like reaction partners, siloxy alkynes are capable of forming small (thr... | 25,171,137 | [
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Building robust carbon nanotube-interweaved-nanocrystal architecture for high-performance anode materials. | Rational design of electrode materials is essential but still a challenge for lithium-ion batteries. Herein, we report the design and fabrication of a class of nanocomposite architecture featured by hierarchically structured composite particles that are built from iron oxide nanocrystals and carbon nanotubes. An aeroso... | 25,171,139 | [
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0.1045083,
0.145275,
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Intrapolypeptide interactions between the GTPase effector domain (GED) and the GTPase domain form the bundle signaling element in dynamin dimers. | Biochemical and structural studies of dynamin have shown that the C-terminus of the GTPase effector domain (GED) folds back and docks onto a platform created by the N- and C-terminal α-helices of the GTPase domain to form a three-helix bundle. While cross-linking studies suggested that insect cell-expressed dynamin exi... | 25,171,143 | [
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... |
Synthesis of new chlorin e6 trimethyl and protoporphyrin IX dimethyl ester derivatives and their photophysical and electrochemical characterizations. | In view of increasing demands for efficient photosensitizers for photodynamic therapy (PDT), we herein report the synthesis and photophysical characterizations of new chlorin e6 trimethyl ester and protoporphyrin IX dimethyl ester dyads as free bases and Zn(II) complexes. The synthesis of these molecules linked at the ... | 25,171,181 | [
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The advantages of unilateral pedal lymphography in the diagnosis of chyluria. | To evaluate the efficacy and safety of pedal lymphography (PLG) in the localization diagnosis of chyluria. Cystoscopy was performed in 153 patients and PLG in 121 cases. Unilateral or staged bilateral ligation and stripping of renal lymphatic vessel were performed according to the results of cystoscopy and/or PLG. Unil... | 25,171,183 | [
0.3950319,
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0.1093391,
-0.08293824,
0.08030441,
0.5656013,
-0.2017833... |
Gate-induced carrier delocalization in quantum dot field effect transistors. | We study gate-controlled, low-temperature resistance and magnetotransport in indium-doped CdSe quantum dot field effect transistors. We show that using the gate to accumulate electrons in the quantum dot channel increases the "localization product" (localization length times dielectric constant) describing transport at... | 25,171,186 | [
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-0.1519625,
-0.05312115,
-0.03313955,
-0.0749... |
Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by NLRP3 gene deletion. | Hyperhomocysteinemia (hHcys) has been reported to initiate Nod-like receptor protein 3 (NLRP3) inflammasome formation and activation in podocytes, leading to glomerular dysfunction and sclerosis. However, it remains unknown whether Nlrp3 gene is critical for the formation and activation of inflammasomes in glomeruli of... | 25,171,193 | [
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0.1430029,
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0.1647466,
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0.1954608,
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0.06860914,
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0.4081681,
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... |
Role of wickability on the critical heat flux of structured superhydrophilic surfaces. | While superhydrophilic coatings with enhanced wetting properties have been shown to increase the pool boiling critical heat flux (CHF), the role of nanostructures on its enhancement is not clear. Here, biological templates have been used to demonstrate that wickability is the single factor dictating CHF on structured s... | 25,171,197 | [
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0.4189334,
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0.09612481,
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0.04619209,
-0.01115649,
0.02409919,
-0.2452879,... |
Comparative study of n-dodecyl tetraethylene monoether lyotropic liquid crystals incorporated with graphene and graphene oxide. | Two kinds of carbon materials, i.e., graphene and graphene oxide (GO), were successfully incorporated into a lyotropic liquid crystal (LLC) matrix formed by n-dodecyl tetraethylene monoether (C12E4). The properties of graphene-C12E4 and GO-C12E4 LLC composites were characterized by UV-vis absorption, transmission elect... | 25,171,198 | [
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0.002108914,
0.2645213,
0.1327662,
0.2550448,
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Biodegradation of complex hydrocarbons in spent engine oil by novel bacterial consortium isolated from deep sea sediment. | Complex hydrocarbon and aromatic compounds degrading marine bacterial strains were isolated from deep sea sediment after enrichment on spent engine (SE) oil. Phenotypic characterization and phylogenetic analysis of 16S rRNA gene sequences showed the isolates were related to members of the Pseudoalteromonas sp., Ruegeri... | 25,171,211 | [
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0.212421,
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0.07173073,
0.3118829,
0.07642431... |
Binding of TDP-43 to the 3'UTR of its cognate mRNA enhances its solubility. | TAR DNA binding protein of 43 kDa (TDP-43) has been implicated in the pathogenesis of a broad range of neurodegenerative diseases termed TDP-43 proteinopathies, which encompass a spectrum of diseases ranging from amyotrophic lateral sclerosis to frontotemporal dementia. Pathologically misfolded and aggregated forms of ... | 25,171,271 | [
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0.03614357,
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0.1570178,
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0.03753844,
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0.004828019,
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0.1846237,
-0.578907,
0.008049259,
0.03603759,
-0.01998235,
0.2649482,
0.2366587,
-0.11350... |
Oligohydramnios in women with preterm prelabor rupture of membranes and adverse pregnancy and neonatal outcomes. | To determine the association between the presence of oligohydramnios, determined as an amniotic fluid index ≤ 5 cm and the intra-amniotic inflammatory response, fetal inflammatory response and neonatal outcomes in actively managed preterm prelabor rupture of membranes (PPROM). Women with singleton pregnancies complicat... | 25,171,293 | [
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0.2368857,
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0.365943,
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0.4951549,
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... |
Stereotactic Body Radiation Therapy (SBRT) Combined With Chemotherapy for Unresected Pancreatic Adenocarcinoma. | The role of radiation therapy in the management of unresectable pancreatic cancer is controversial. One concern about concurrent chemoradiation relates to the timing of chemotherapy. In contrast to conventional radiation therapy, stereotactic body radiation therapy (SBRT) delivers high doses in a shorter duration resul... | 25,171,298 | [
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0.1381964,
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0.40159,
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0.4900093,
0.4222527,
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0.3296777,
0.06240566,
... |
Time to culture positivity and sputum smear microscopy during tuberculosis therapy. | Sputum smear microscopy is widely used for tuberculosis diagnosis and treatment monitoring. We evaluated the correlation between smear microscopy and time to liquid culture positivity during early tuberculosis treatment. The study included patients with smear-positive pulmonary tuberculosis hospitalized at a tuberculos... | 25,171,337 | [
-0.00518208,
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0.1873152,
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0.009116331,
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0.3703313,
0.112111,
-0.1579553,
0.2654813,
0.5293475,
-0.03803591,
0.0245816... |
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