title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming. | The process that converts somatic cells to pluripotent ones has enormous potential not only as a tool to generate cells for disease therapy and modeling, but also as an experimental system to investigate fundamental biological questions. The discovery of mesenchymal-to-epithelial transitions at the initial phase of rep... | 25,173,869 | [
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Long-term evolution of the composition of surface water from the River Gharasoo, Iran: a case study using multivariate statistical techniques. | We report an assessment of the quality of surface water from the River Gharasoo, Iran, with rainfall data. EC, pH, HCO(3)(-), Cl(-), SO(4), Ca(2+), Mg(2+), Na(+), %Na, and sodium adsorption ratio results, monitored monthly by two sampling stations over a period of 40 years, were held by the Hydraulic Works Organization... | 25,173,877 | [
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Ocular motility abnormalities in orbitofacial neurofibromatosis type 1. | To evaluate the causes of ocular motility disturbances in a group of patients with orbitofacial neurofibromatosis (OFNF) with neurofibromas on the lid, brow, face, or in the orbit from infancy or early childhood. The medical records of patients with OFNF from one institution were retrospectively reviewed; selected pati... | 25,173,895 | [
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Clinical problems in strabismus: the Smith-Kettlewell Eye Research Institute symposium. | The Smith Kettlewell Eye Research Institute (SKERI), celebrating its 50th anniversary in 2014, hosted a symposium to identify the most pressing clinical problems in strabismus and binocular vision. Forty-five experts from around the world shared their perspectives at the San Francisco meeting, held November 6-9, 2012. ... | 25,173,911 | [
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Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance. | In the insulin resistant heart, energy fuel selection shifts away from glucose utilization towards almost complete dependence on long-chain fatty acids (LCFA). This shift results in excessive cardiac lipid accumulation and eventually heart failure. Lipid-induced cardiomyopathy may be averted by strategies that increase... | 25,173,922 | [
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Induction of oxidative stress in Prototheca zopfii by indole-3-acetic acid/HRP or 2,4-pentanedione/HRP systems and their oxidation products. | We investigated the toxic effects on Prototheca zopfii of indole-3-acetic acid (IAA) and 2,4-pentanedione (PD) combined with horseradish peroxidase (HRP) alongside the oxidation products of 3-methyl-2-oxindole (MOI) and indole-3-carbinol (I3C) from the IAA/HRP system and methylglyoxal (MGO) from the PD/HRP system. The ... | 25,173,924 | [
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The GH26 β-mannanase RsMan26H from a symbiotic protist of the termite Reticulitermes speratus is an endo-processive mannobiohydrolase: heterologous expression and characterization. | Symbiotic protists in the gut of termites are prominent natural resources for enzymes involved in lignocellulose degradation. Here we report expression, purification, and biochemical characterization of a glycoside hydrolase family 26 mannanase RsMan26H from the symbiotic protist of the lower termite, Reticulitermes sp... | 25,173,929 | [
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Nitrate (NO3(-)) and nitrite (NO2(-)) are endocrine disruptors to downregulate expression of tyrosine hydroxylase and motor behavior through conversion to nitric oxide in early development of zebrafish. | With a view to consider the increasing concern over nitrogen pollution in the aquatic environment, we investigated effects of nitrate (NO3(-)) and nitrite (NO2(-)) on the activity of dopaminergic neuron in zebrafish embryos and larvae. Both nitrate and nitrite exposure decreased the expression of tyrosine hydroxylase (... | 25,173,937 | [
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Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent. | Periostin, as an extracellular matrix (ECM) protein, plays a critical role in myocardial fibrosis and also might be involved in the heart inflammatory process since it is a downstream molecule of IL4 and IL13. Considering the possible important role of periostin in heart aging, this study explored periostin expression ... | 25,173,938 | [
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Update of (40)K and (226)Ra and (232)Th series γ-to-dose conversion factors for soil. | Over the last four decades, the dose conversion factors used to calculate external exposure to γ radiation from soil from (40)K and the (226)Ra and (232)Th chains have been 0.62, 0.042 and 0.46 (nGy/h per Bq/kg), respectively. This work updates these γ-to-dose conversion factors, taking into consideration the compositi... | 25,173,948 | [
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Seasonality in birth defects, agricultural production and urban location. | This paper tests whether the strength of the "spring spike" in birth defects is related to agricultural production and urban location using Texas Birth Defects Registry data for the period 1996-2007. We find evidence of a spike in birth defects among children conceived in the spring and summer, but it is more pronounce... | 25,173,949 | [
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Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens. | Cell differentiation and response to hormonal signals were studied in a 3D environment on an in-house generated mouse fibroblast cell line expressing a reporter gene under the control of estrogen responsive sequences (EREs). 3D cell culture conditions were obtained in a Rotary Cell Culture System; (RCCS™), a microgravi... | 25,173,957 | [
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Memory labilization in reconsolidation and extinction--evidence for a common plasticity system? | Reconsolidation and extinction are two processes occurring upon memory retrieval that have received great attention in memory research over the last decade, partly due to their purported potential in the treatment of anxiety disorders. Due to their opposite behavioral effects, the two phenomena have usually been consid... | 25,173,958 | [
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Impact of toilet hygiene training program: results from 11- to 16-year-old secondary school Turkish children. | The purpose of the study is to evaluate the effectiveness of toilet hygiene education in secondary school students. The study was quasi-experimental with a pre-test-post-test design and includes a control group. The study was conducted at a secondary school in Istanbul, Turkey with 100 students (50 students for experim... | 25,173,963 | [
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Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. | Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signalling affects ciliogenesis by regulating anterograde intraflagellar tra... | 25,173,977 | [
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EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. | Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic inflammation and diverse signalling pathways, including the epidermal growth factor receptor (EGFR) pathway. The precise role of EGFR in HCC is unknown, a... | 25,173,978 | [
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Soil seed banks and their germination responses to cadmium and salinity stresses in coastal wetlands affected by reclamation and urbanization based on indoor and outdoor experiments. | Indoor and outdoor seedling emergence experiments were conducted to thoroughly investigate germination patterns as affected by reclamation and urbanization, the ecological characteristics of soil seed banks, and their relationships with environmental factors in both urbanized and reclaimed regions of the Pearl River De... | 25,173,982 | [
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Determination of Δ9-tetrahydrocannabinolic acid A (Δ9-THCA-A) in whole blood and plasma by LC-MS/MS and application in authentic samples from drivers suspected of driving under the influence of cannabis. | Delta-9-tetrahydrocannabinolic acid A (THCA-A) is the biosynthetic precursor of delta-9-tetrahydrocannabinol (THC) in cannabis plants, and has no psychotropic effects. THCA-A can be detected in blood and urine, and several metabolites have been identified. THCA-A was also shown to be incorporated in hair by side stream... | 25,173,986 | [
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Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. | Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automate... | 25,174,001 | [
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Edge-orientation processing in first-order tactile neurons. | A fundamental feature of first-order neurons in the tactile system is that their distal axon branches in the skin and forms many transduction sites, yielding complex receptive fields with many highly sensitive zones. We found that this arrangement constitutes a peripheral neural mechanism that allows individual neurons... | 25,174,006 | [
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Evaluating sexual health planning for the London 2012 Olympics. | The public health impact of mass gatherings should not be underestimated, requiring careful planning. This evaluation identified the successes and failures of a programme targeted to mitigate against potential increases in sexual ill health during the London 2012 Olympics. Programme planning was evaluated using documen... | 25,174,041 | [
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Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey. | ACE (adverse childhood experience) studies typically examine the links between childhood stressors and adult health harming behaviours. Using an enhanced ACE survey methodology, we examine impacts of ACEs on non-communicable diseases and incorporate a proxy measure of premature mortality in England. A nationally repres... | 25,174,044 | [
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[Study on content of volatile oil in Amomum tsao-ko seeds and its influencing factors]. | To lay the foundation for quality evaluation of medicinal materials of Amomum tsao-ko and its selection of fine varieties, the variation of percentage of volatile oil in the seeds among populations and individuals and its influencing factors were studied. Extracted volatile oil from the seeds according to the Chinese P... | 25,174,100 | [
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[Apoptosis of melanoma B16 cells induced by gambogenic acid]. | To study the inhibitory effect of Gambogenic acid (GNA) on melanoma B16 cells proliferation, and to explore the role of cell apoptosis. The inhibitory effect of GNA on the proliferation of B16 cells was measured by methyl thiazolyl tetrazolium (MTT) assay; Alternation of B16 cells ultrastructure was detected by AO/EB s... | 25,174,115 | [
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Cardiac arrest equipment to support airway. | Each hospital should have standardised cardiac arrest trolleys equipped with all the instruments and medication needed to deal with an acute adult cardiac arrest. Nurses must know the contents of these trolleys and how to use them to fulfil their common role as first responder. This first article in a two-part series l... | 25,174,131 | [
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Comparison of procedure costs of various percutaneous tumor ablation modalities. | Microwave ablation, radiofrequency ablation, cryoablation, and irreversible electroporation are percutaneous ablation modalities commonly employed to treat tumors. The procedure cost of treating the same lesion with each of the four modalities is compared. A cost model was created for each ablation modality estimating ... | 25,174,139 | [
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Structural strength evaluation of driver's protective structures for self-propelled agricultural machines. | The high number of accidents due to rollovers of agricultural machines has increased the interest of researchers and organizations for standardization in this field. In the 1960s, standards to test rollover protective structures (ROPS) for tractors were designed and approved. Similar standards were introduced in the 19... | 25,174,149 | [
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[Incisors with a mind of their own]. | A 43-year-old man, known to have hypodontia, was bothered by his over-erupted central incisors. After the placement of implants and the accompanying crown- and bridgework, the central incisors appear to be increasingly over-erupted. The history shows that this phenomenon has already been seen in the past. Three mechani... | 25,174,187 | [
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Airway centric TMJ philosophy. | The airway governs our ability to breathe and to achieve a restful, oxygenated, restorative night's sleep, as well as to perform optimally during the day. Any temporomandibular joint or occlusal philosophy must address airway patency while managing pain and dysfunction, identifying contributing factors and alleviating ... | 25,174,213 | [
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Language and cognitive predictors of text comprehension: evidence from multivariate analysis. | Using data from children in South Korea (N = 145, Mage = 6.08), it was determined how low-level language and cognitive skills (vocabulary, syntactic knowledge, and working memory) and high-level cognitive skills (comprehension monitoring and theory of mind [ToM]) are related to listening comprehension and whether liste... | 25,174,258 | [
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Contact dermatitis-like cutaneous leishmaniasis in a Libyan HIV patient. | Cutaneous leishmaniasis (CL) is one of the common tropical protozoal diseases caused by various Leishmania species, and transmitted by the sand-fly vectors, Phlebotomus and Lutzomyia species. Herein, we report for the first time a case of CL that presented as large eczematous plaques occurring on the dorsi of both feet... | 25,174,279 | [
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0.0665853... |
Aquaporin 4-dependent expression of glial fibrillary acidic protein and tenascin-C in activated astrocytes in stab wound mouse brain and in primary culture. | We previously reported that aquaporin 4 (AQP4) has a neuroimmunological function via astrocytes and microglial cells involving osteopontin. AQP4 is a water channel localized in the endofoot of astrocytes in the brain, and its expression is upregulated after a stab wound to the mouse brain or the injection of methylmerc... | 25,174,305 | [
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Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations. | Bone metastasis represents the leading cause of breast cancer related-deaths. However, the effect of skeleton-associated biomechanical signals on the initiation, progression, and therapy response of breast cancer bone metastasis is largely unknown. This review seeks to highlight possible functional connections between ... | 25,174,311 | [
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Trace elements and heavy metals in mineral and bottled drinking waters on the Iranian market. | A survey of Iranian waters, sampled from 2010 to 2013, is presented. A total of 128 water samples from 42 different brands of bottled mineral and drinking water were collected and analysed for contamination levels of lead (Pb), cadmium (Cd), copper (Cu), arsenic (As) and mercury (Hg). Determinations were performed usin... | 25,174,358 | [
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Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation. | The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which also interac... | 25,174,360 | [
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[Development of hospital pharmacy practice using therapeutic drug monitoring]. | Therapeutic drug monitoring (TDM) is a developing field in hospital pharmacy that contributes to good clinical response. Optimal concentrations of immunosuppressants, anti-epileptic drugs, and glycopeptide antibiotics are narrow, and these drugs are widely monitored by fluorescence polarization immunoassay (FPIA) in cl... | 25,174,365 | [
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[Effects of recombinant human granulocyte-macrophage colony-stimulating factor on wound healing and microRNA expression in diabetic rats]. | To investigate the effects of recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) on wound healing and microRNA expression in diabetic rats. Eighteen male SD rats of clean grade were used to reproduce diabetes model. Four weeks later, a total of 64 full-thickness skin wounds were created on th... | 25,174,387 | [
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[Advances in the research on bactericidal effect of blue light and its mechanism]. | Blue light is commonly used to kill Propionibacterium acnes in clinic. Furthermore, blue light exhibits a good bactericidal effect against Helicobacter pylori, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and many oral bacteria in laboratory studies. The bactericidal mechanism of blue light as c... | 25,174,390 | [
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Suppression of scinderin modulates epithelial‑mesenchymal transition markers in highly metastatic gastric cancer cell line SGC‑7901. | Scinderin is a Ca2+‑dependent filamentous actin (F‑actin) severing and capping protein, which has a key role in regulated secretion. However, little is known regarding the function and mechanism of scinderin in human carcinoma development and progression. In the present study, the biological function of scinderin was i... | 25,174,406 | [
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Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice. | Chronic inflammation is an underlying risk factor for colorectal cancer. No direct evidence has proven that inflammation in the colon promotes carcinogenesis. STAT3 plays an important role in the development of colitis-associated colorectal cancer (CAC). There is crosstalk between the mammalian target of rapamycin comp... | 25,174,408 | [
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Decontamination activity of ryegrass exudates towards bisphenol A in the absence and presence of dissolved natural organic matter. | Bisphenol A (BPA) is an endocrine disruptor compound widespread in terrestrial and aquatic systems of urbanized and industrialized regions. This study evaluated the capacity of ryegrass (Lolium perenne) aqueous exudates to degrade BPA at a concentration of 10 mg L(-1) both in the absence and in the presence of an organ... | 25,174,419 | [
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A systematic review and meta-analysis of the nutrient content of preterm and term breast milk. | Breast milk nutrient content varies with prematurity and postnatal age. Our aims were to conduct a meta-analysis of preterm and term breast milk nutrient content (energy, protein, lactose, oligosaccharides, fat, calcium, and phosphorus); and to assess the influence of gestational and postnatal age. Additionally we asse... | 25,174,435 | [
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Phytosulfokine peptide signaling controls pollen tube growth and funicular pollen tube guidance in Arabidopsis thaliana. | Phytosulfokine (PSK) is a peptide growth factor that requires tyrosine sulfation carried out by tyrosylprotein sulfotransferase (TPST) for its activity. PSK is processed from precursor proteins encoded by five genes in Arabidopsis thaliana and perceived by receptor kinases encoded by two genes in Arabidopsis. pskr1-3 p... | 25,174,442 | [
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Milk thistle seed extract protects rat C6 astroglial cells from acute cocaine toxicity. | Cocaine is a powerful addictive drug, widely abused in most Western countries. It easily reaches various domains within and outside of the central nervous system (CNS), and triggers varying levels of cellular toxicity. No pharmacological treatment is available to alleviate cocaine-induced toxicity in the cells without ... | 25,174,449 | [
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Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in ovarian serous borderline tumors. | Serous borderline tumors and low-grade serous adenocarcinomas typically exhibit a low mitotic index and are largely resistant to chemotherapy. They are characterized by specific mutations, including mutations of KRAS and BRAF, which target specific cell signaling pathways. Mutational analyses may provide further insigh... | 25,174,456 | [
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[A cohort study on the impacts of pre-pregnancy maternal body mass index, gestational weight gain on neonate birth status and perinatal outcomes in Fujian province]. | To study the impacts of pre-pregnancy maternal BMI and gestational weight gain(GWG) on pregnancy outcomes. We adopted a prospective cohort study with cluster sampling in single pregnant women, who were not with hypertension, diabetes, hyperlipidemia or other diseases in the previous history, neither did they have disea... | 25,174,462 | [
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[Association between folic acid supplement in peri-conceptional period and depression in pregnancy: a cohort study]. | To describe the epidemiological characteristics on the supplement of folic acid in progestation and early pregnancy, and to probe the protective effects of supplement of folic acid in early pregnancy against pregnant depression, in Ma'anshan city, Anhui province. In this cohort study, 5 150 subjects who had their first... | 25,174,463 | [
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[Heat vulnerability assessment in Jinan city: a comparison between residents living in urban centers and urban-fringe areas]. | To find out the differences in regional characteristics of heat vulnerability between people living in urban centers and urban-fringe areas of Jinan city so as to provide basis for the development of adaptation measures to heat. A cross-sectional survey on heat vulnerability was conducted in urban center and urban-frin... | 25,174,469 | [
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[Burden on blood-pressure-related diseases among the Chinese population, in 2010]. | To quantify the burden of disease related to high blood pressure in the Chinese population. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) in China. Data for mean systolic blood pressure, burden of deaths,Years of Life Lost(YLLs), Years Lived with Disability (YLDs),... | 25,174,471 | [
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Methiozolin sorption and mobility in sand-based root zones. | Methiozolin is a herbicide currently used for annual bluegrass control in golf course putting greens. Previous research indicates that maximum weed control efficacy requires root exposure; however, soil sorption and mobility of methiozolin have not been established. Research was conducted to investigate soil sorption a... | 25,174,500 | [
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0.3602797,
0.04671852... |
Serotype-conversion in Shigella flexneri: identification of a novel bacteriophage, Sf101, from a serotype 7a strain. | Shigella flexneri is the major cause of bacillary dysentery in the developing countries. The lipopolysaccharide (LPS) O-antigen of S. flexneri plays an important role in its pathogenesis and also divides S. flexneri into 19 serotypes. All the serotypes with an exception for serotype 6 share a common O-antigen backbone ... | 25,174,528 | [
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Effect of the number of suture throws on the biomechanical characteristics of the suture-tendon construct. | We aimed to investigate the effect of the number of suture throws on biomechanical characteristics of the suture-tendon construct for 3 currently used suture configurations in this ex vivo biomechanical study. Three stitch configurations-the Krackow stitch, the locking SpeedWhip (LSW) stitch, and the modified finger tr... | 25,174,535 | [
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Radiation-induced morphea - a literature review. | Radiation-induced morphea (RIM) is a rare and under-recognized skin complication of radiotherapy. It is commonly wrongly diagnosed as other dermatological conditions or malignancy because of similar clinical characteristics. This literature review analyses 66 cases that have been reported in the literature since 1989. ... | 25,174,551 | [
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Galloylated flavonol rhamnosides from the leaves of Calliandra tergemina with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). | Galloylated flavonol rhamnosides identified as kaempferol-3-O-(2″,3″,4″-tri-O-galloyl)-α-l-rhamnopyranoside, quercetin-3-O-(3″,4″-di-O-galloyl)-α-l-rhamnopyranoside, and quercetin-3-O-(2″,3″,4″-tri-O-galloyl)-α-l-rhamnopyranoside, together with five known galloylated and non-galloylated flavonol rhamnosides, were isola... | 25,174,555 | [
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... |
On-line monitoring of fluid bed granulation by photometric imaging. | This paper introduces and discusses a photometric surface imaging approach for on-line monitoring of fluid bed granulation. Five granule batches consisting of paracetamol and varying amounts of lactose and microcrystalline cellulose were manufactured with an instrumented fluid bed granulator. Photometric images and NIR... | 25,174,556 | [
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Association of the ASCO classification with the executive function subscores of the Montreal cognitive assessment in patients with postischemic stroke. | The ASCO classification can evaluate the etiology and mechanisms of ischemic stroke more comprehensively and systematically than conventional stroke classification systems such as Trial of Org 10172 in Acute Stroke Treatment (TOAST). Simultaneously, risk factors for cognitive impairment such as arterial sclerosis, leuk... | 25,174,562 | [
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Generation of a Cre knock-in into the Myocardin locus to mark early cardiac and smooth muscle cell lineages. | The molecular events that control cell fate determination in cardiac and smooth muscle lineages remain elusive. Myocardin is an important transcription cofactor that regulates cell proliferation, differentiation, and development of the cardiovascular system. Here, we describe the construction and analysis of a dual Cre... | 25,174,608 | [
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The end of AIDS: possibility or pipe dream? A tale of transitions. | Globally, in the last 20 years health has improved. In this generally optimistic setting HIV and AIDS accounts for the fastest growing burden of disease. The data show the bulk of this is experienced in Southern Africa. In this region, HIV and AIDS (and tuberculosis [TB]) peaks among young adults. Women carry the great... | 25,174,627 | [
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The economics, financing and implementation of HIV treatment as prevention: what will it take to get there? | The 2013 Lancet Commission Report, Global Health 2035, rightly pointed out that we are at a unique place in history where a "grand convergence" of health initiatives to reduce both infectious diseases, and child and maternal mortality--diseases that still plague low income countries--would yield good returns in terms o... | 25,174,628 | [
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Barriers and facilitators to the uptake of voluntary medical male circumcision (VMMC) among adolescent boys in KwaZulu-Natal, South Africa. | Epidemiological modelling has concluded that if voluntary medical male circumcision (VMMC) is scaled up in high HIV prevalence settings it would lead to a significant reduction in HIV incidence rates. Following the adoption of this evidence by the WHO, South Africa has embarked on an ambitious VMMC programme. However, ... | 25,174,635 | [
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'Children will always be children': exploring perceptions and experiences of HIV-positive children who may not take their treatment and why they may not tell. | HIV-positive children and young people may face substantial social barriers to maintaining appropriate levels of adherence to antiretroviral therapy (ART) during childhood and adolescence. In this paper, we focus on these children's voices and the challenges they face growing up living with HIV in Uganda. Drawing on re... | 25,174,636 | [
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Transcriptome differences in the hypopharyngeal gland between Western Honeybees (Apis mellifera) and Eastern Honeybees (Apis cerana). | Apis mellifera and Apis cerana are two sibling species of Apidae. Apis cerana is adept at collecting sporadic nectar in mountain and forest region and exhibits stiffer hardiness and acarid resistance as a result of natural selection, whereas Apis mellifera has the advantage of producing royal jelly. To identify differe... | 25,174,638 | [
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Incidence and risk factors for intussusception among children in northern Israel from 1992 to 2009: a retrospective study. | Determining the background incidence of intussusception is important in countries implementing rotavirus immunization. Rotavirus immunization was introduced into the routine infant immunization program in Israel during late 2010. Incidence and risk factors for intussusception were examined in children aged less than fi... | 25,174,640 | [
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Parkinson's disease and local atrophy in subcortical nuclei: insight from shape analysis. | Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, inducing dopaminergic depletion in the striatum. Recently, subcortical nuclei shape analysis based on T1 imaging has been used in PD pathology. The present study aimed to test the hypothesis that changes in ... | 25,174,648 | [
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The immune-related role of BRAF in melanoma. | The existence of a dichotomy between immunologically active and quiescent tumor phenotypes has been recently recognized in several types of cancer. The activation of a Th1 type of immune signature has been shown to confer better prognosis and likelihood to respond to immunotherapy. However, whether such dichotomy depen... | 25,174,651 | [
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Molecular and epidemiological study of human parechovirus infections in Taiwan, 2007-2012. | As routine diagnostic assays for human parechoviruses (HPeVs) have not been included in the enteroviruses surveillance network in Taiwan, HPeVs may be the actual pathogens of hundreds of untypeable enteroviruses-suspected isolates. In this study, these untypeable isolates collected from 2007 through 2012 were examined ... | 25,174,670 | [
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Effects of antioxidants and additional emulsifiers on the stability of emulsified milk fat in the photo/radical oxidation system. | The effects of antioxidants on the oxidative deterioration of emulsified oils and fats differ depending on the oxidation conditions, oils and fats used, and type of emulsifier. In this study, milk fat was emulsified to obtain water-oil (O/W) emulsion using Tween20 as emulsifier. The antioxidative effects of several ant... | 25,174,675 | [
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Spontaneous local alpha oscillations predict motion-induced blindness. | Bistable visual illusions are well suited for exploring the neuronal states of the brain underlying changes in perception. In this study, we investigated oscillatory activity associated with 'motion-induced blindness' (MIB), which denotes the perceptual disappearance of salient target stimuli when a moving pattern is s... | 25,174,681 | [
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The invertebrate midintestinal gland ("hepatopancreas") is an evolutionary forerunner in the integration of immunity and metabolism. | The immune system has an impact on the metabolic performance in vertebrates, thus the metabolic effects of immune cells are receiving intense attention today in the biomedical field. However, the evolutionary origin of the immunity-metabolism interaction is still uncertain. In this review, I show that mollusks and crus... | 25,174,684 | [
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Morpho-colorimetric analysis and seed germination of Brassica insularis Moris (Brassicaceae) populations. | Brassica insularis is a perennial plant growing on both coastal and inland cliffs. Three seed lots from Sardinia were analysed using an image analysis system to detect differences in seed morphology, both within and among populations. Germination requirements at constant (5-25 °C) and alternating temperatures (25/10 °C... | 25,174,700 | [
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Brain antioxidant responses to acute iron and copper intoxications in rats. | Dose- and time-dependent antioxidant responses to Fe (0-60 mg kg(-1)) and Cu overloads (0-30 mg kg(-1)) in rat brains are described by the C50 and the t1/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH/GSSG ratio markedly decreased after Fe and Cu treatments (50... | 25,174,705 | [
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Recent developments in antiplatelet therapy after percutaneus coronary intervention. | Antiplatelet therapy plays an important role in the treatment of patients suffering from acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) in order to prevent atherothrombotic events and restenosis or ischemic reocclusion, respectively. Moreover, stent implantation is often performed ... | 25,174,713 | [
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Questionnaires in the assessment of sexual function in women with urinary incontinence and pelvic organ prolapse. | Integrating sexual health in clinical practice is important. In women with pelvic floor disorders, the evaluation of the anatomical defects, lower urinary tract function and the anorectal function often receives more attention than the sexual function. Review of Medline using defined search terms to identify articles r... | 25,174,768 | [
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A step towards understanding the mechanisms of running-related injuries. | To investigate the association between training-related characteristics and running-related injury using a new conceptual model for running-related injury generation, focusing on the synergy between training load and previous injuries, short-term running experience or body mass index (> or < 25 kg m(-2)). Prospec... | 25,174,773 | [
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Initial LDCT appearance of incident lung cancers in the ITALUNG trial. | To characterize early features of lung cancers detected with low-dose computed tomography (LDCT) screening. Two radiologists reviewed prior LDCTs in 20 incident cancers diagnosed at annual repeat screening rounds and 83 benign nodules observed in the ITALUNG trial. No abnormality was observed in 3 cancers. Focal abnorm... | 25,174,775 | [
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Regioselective deuterium labeling of estrone and catechol estrogen metabolites. | Increased exposure to estrogens and estrogen metabolites is linked with increased rates of breast, ovarian and other human cancers. Metabolism of estrogen can led to formation of electrophilic o-quinones capable of binding to DNA. In order to gain insight into the mechanism of estrogen-induced DNA damage, estrone and c... | 25,174,785 | [
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Advocacy: the role of health professional associations. | The FIGO Leadership in Obstetrics and Gynecology for Impact and Change (LOGIC) Initiative in Maternal and Newborn Health was developed on the premise that organizational capacity strengthening in eight low- and middle-income countries would result in improved ability of member associations to take a leadership role in ... | 25,174,787 | [
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Understanding the magnitude of emergent contaminant releases through target screening and metabolite identification using high resolution mass spectrometry: Illicit drugs in raw sewage influents. | A QExactive Orbitrap was used for the identification of phase I and II transformation products (TPs) of illicit drugs in raw sewage influents. Two operating modes (targeted MS(2) and Data-dependent screening) were used for data acquisition. Even though, data-dependent scan is a faster route towards the potential identi... | 25,174,793 | [
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Follow-up and long-term outcome of nonfunctioning pituitary adenoma operated by transsphenoidal surgery with intraoperative high-field magnetic resonance imaging. | Intraoperative MRI (iMRI) increases gross total resection (GTR) rates in transsphenoidal surgery; however, long-term follow-up data is lacking. The objective is to assess the outcome of patients with nonfunctioning pituitary adenomas (NFA) at a mean follow-up of > 5 years. Patients with NFA operated in a single inst... | 25,174,805 | [
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Identification of copy number variation-driven genes for liver cancer via bioinformatics analysis. | To screen out copy number variation (CNV)-driven differentially expressed genes (DEGs) in liver cancer and advance our understanding of the pathogenesis, an integrated analysis of liver cancer-related CNV data from The Cancer Genome Atlas (TCGA) and gene expression data from EBI Array Express database were performed. T... | 25,174,835 | [
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Ultrastructure and development of Nosema podocotyloidis n. sp. (Microsporidia), a hyperparasite of Podocotyloides magnatestis (Trematoda), a parasite of Parapristipoma octolineatum (Teleostei). | Nosema podocotyloidis n. sp. (Microsporidia, Nosematidae) is described from Podocotyloides magnatestis (Trematoda: Opecoelidae), a parasite of the fish Parapristipoma octolineatum (Teleostei) in the Atlantic Ocean. Electron microscopy reveals that all the stages of the cycle (merogony and sporogony) are diplokaryotic a... | 25,174,849 | [
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0.1128604,
... |
Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence. | Filaggrin is an epidermal protein that has a role in skin barrier function. Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and atopy, but their association with food allergy (FA) is less clear. We explored the longitudinal relationship between 3 common FLG-LOF mutations and FA u... | 25,174,864 | [
0.2945806,
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0.3721996,
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0.04096379,
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0.2344606,
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0.0246863,
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0.4729126,
-0.3767302,
... |
Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: A cluster-randomized trial in primary care. | Aiming at partly controlled asthma (PCa) instead of controlled asthma (Ca) might decrease asthma medication use. Biomarkers, such as the fraction of exhaled nitric oxide (Feno), allow further tailoring of treatment. We sought to assess the cost-effectiveness and clinical effectiveness of pursuing PCa, Ca, or Feno-drive... | 25,174,865 | [
-0.04224896,
0.5282237,
0.1821591,
0.02860747,
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0.1673627,
0.145915,
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0.04168575,
0.1466155,
0.08535668,
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0.07962488,
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0.1218974,
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0.118502,
-0.3338536,
0.08081735,
-0.2336992,
... |
Near-infrared fundus autofluorescence in subclinical best vitelliform macular dystrophy. | To describe fundus autofluorescence (FAF) on short-wavelength FAF and near-infrared FAF in the subclinical form of Best vitelliform macular dystrophy. Cross-sectional prospective study. Patients affected by the subclinical form of Best vitelliform macular dystrophy (positive testing for BEST1 gene mutation, fully prese... | 25,174,897 | [
0.1429784,
0.01053991,
-0.05465529,
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0.1642588,
0.1384065,
0.151095,
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0.3526258,
0.1746832,
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-0.7695131,
0.198938,
0.1235961,
-0.2276134,
-0.0942863,
0.7364351,
-0.02277298,
-0.... |
Small molecule inhibitors in veterinary oncology practice. | Recent advances in molecular biology have permitted the identification and characterization of specific abnormalities regarding cell signaling and function in cancer cells. Proteins that are found to be dysregulated in cancer cells can serve as relevant targets for therapeutic intervention. Although there are several a... | 25,174,906 | [
-0.02327021,
0.01385483,
0.2637859,
-0.6540754,
-0.1583351,
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0.05934425,
0.1576863,
0.04301633,
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0.1386904,
0.1582021,
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0.08570667,
-0.3005241,
0.1317057,
0.1236414,
-0.001833776,
-0.02017596,
0.376284,
-0.1897459,... |
Validation of acute myocardial infarction cases in the national health insurance research database in taiwan. | The aim of this study was to determine the validity of acute myocardial infarction (AMI) diagnosis coding in the National Health Insurance Research Database (NHIRD) by cross-comparisons of discharge diagnoses listed in the NHIRD with those in the medical records obtained from a medical center in Taiwan. This was a cros... | 25,174,915 | [
-0.07257191,
0.01193568,
-0.1884077,
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0.09566889,
0.1041285,
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0.1951373,
0.2210783,
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0.07673491,
0.4491646,
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0.01257432,
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0.143362,
0.3395779,
-0.05585824,
0.02886777,
0.08962152,
-0.2878037,
-0.2357556,
... |
Thyroglobulin autoantibodies as surrogate biomarkers in the management of patients with differentiated thyroid carcinoma. | Differentiated thyroid cancer is a rare malignancy, but leaves numerous survivors for life-long follow-up. The cornerstone in current guidelines for follow-up is by measuring the thyroid specific tumour marker, thyroglobulin in serum. Most patients can be followed by this method, but some thyroid cancer patients have a... | 25,174,917 | [
-0.1243363,
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0.3204664,
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0.2639838,
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0.2086074,
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0.09866744,
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-0.1671621,
0.009193677,
0.06000364,
0.1010139,
0.1342519,
-0.3484088... |
Gauging reactive metabolites in drug-induced toxicity. | Over the past decades, it has become abundantly clear that enzymes evolved to detoxify and eliminate foreign chemicals from the body, occasionally generate highly reactive metabolites which have toxicological implications. To decrease the probability of late clinical failure or market withdrawal, there has been an incr... | 25,174,933 | [
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0.3513396,
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0.1448971,
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0.1985822,
0.2784318,
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0.2196444,
0.2399182,
0.2088902,
-0.1382876,
0.2862635,
-0.2104072,
-0.... |
Arthroscopic all-intra-articular decompression and labral repair of paralabral cyst in the shoulder. | The purpose of this study was to report the outcomes of all-intra-articular arthroscopic decompression and labral repair in patients with symptomatic paralabral cysts. From 2005 to 2011, 20 consecutive cases of symptomatic paralabral cysts were included in this study. All surgical procedures were conducted with intra-a... | 25,174,937 | [
0.002732991,
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0.242287,
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0.09088045,
-0.03887793,
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0.04125013,
-0.3251298,
-0.01928952,
-0.1371586,
0.02407407,
0.1793115,
0.1453837,
-0.02055752... |
Comparison of fatigue resistance and failure modes between metal-ceramic and all-ceramic crowns by cyclic loading in water. | To compare fatigue resistance and fracture mode of metal-ceramic crowns with all-ceramic crowns containing yttria tetragonal zirconia polycrystal (Y-TZP) frameworks under compressive cycling loading in water. Twenty specimens of ivory were randomized and individually prepared to receive anatomically shaped metal-cerami... | 25,174,946 | [
-0.1258544,
0.3649264,
0.2512074,
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0.01179401,
0.3094497,
0.08334457,
0.3935171,
0.07266848,
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0.04851691,
0.1223814,
-0.4934168,
-0.2187789,
0.05881013,
0.1499003,
-0.1544208,
... |
Surface properties of monolithic zirconia after dental adjustment treatments and in vitro wear simulation. | To investigate the surface properties (roughness, composition, phase transformation) of monolithic zirconia specimens after dental adjustment procedures (grinding, polishing) and wear simulation. Zirconia specimens (Cercon base, Cercon ht, DeguDent, G; n=10/material) were successively sintered, ground, and polished wit... | 25,174,949 | [
-0.01457428,
0.2439592,
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0.05985184,
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0.2545632,
0.2101884,
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0.1563897,
0.01362691,
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0.1102228,
-0.1513325,
-0.05943667,
-0.2723298,
0.11292,
0.2806538,
0.1047217,
-0.03318517,
... |
Guaiacol and 4-methylphenol as specific markers of torrefied malts. Fate of volatile phenols in special beers through aging. | Phenol-specific extracts of 12 Belgian special beers were analyzed by gas chromatography hyphenated to olfactometry (AEDA procedure) and mass spectrometry (single ion monitoring mode). As guaiacol and 4-methylphenol were revealed to be more concentrated in brown beers (>3.5 and >1.1 μg/L, respectively), they are ... | 25,174,984 | [
0.1691397,
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-0.2941091,
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0.08919797,
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0.1335928,
0.1120901,
0.0251374,
0.003117253,
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0.3456273,
0.09319431,
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0.2214639,
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0.4887461,
0.3600294,
0.09757612,
0.3747998,
0.2230242,
-0.2742647,
... |
Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract. | This research aimed at reporting the synthesis, characterization and evaluation of the anti-inflammatory effects of some new biomaterials based on silver nanoparticles and polyphenols rich natural extracts. A fast and eco-friendly extracellular biosynthesis of silver nanoparticles (AgNPs), using European black elderber... | 25,174,985 | [
-0.02478064,
0.1522048,
-0.3833626,
0.2441931,
0.2358954,
0.1449204,
-0.247727,
0.1316714,
0.2665099,
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-0.2956598,
-0.2687159,
-0.005473633,
-0.2348321,
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0.3632724,
-0.3547832,
0.2656355,
0.04969959,
0.05752743,
0.3384853,
0.3692964,
-0.5118892,
-0... |
Genetic associations between temperament and performance traits in Nellore beef cattle. | The aim of this study was to estimate genetic associations between temperament and performance traits. Temperament was evaluated in yearling male and female Nellore cattle, using four traits: temperament score (TS), for assessing animals' reactions in a corral pen (n = 25,691); movement score (MOV), for animals' moveme... | 25,174,988 | [
0.2184748,
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0.2014968,
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0.1833859,
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-0.2073454,
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0.01881316,
0.1230407,
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0.01663521,
-0.5764537,
0.05999068,
0.3527809,
0.09339359,
0.2983393,
0.1783279,
-0.2463421,
... |
Spiking neural circuits with dendritic stimulus processors : encoding, decoding, and identification in reproducing kernel Hilbert spaces. | We present a multi-input multi-output neural circuit architecture for nonlinear processing and encoding of stimuli in the spike domain. In this architecture a bank of dendritic stimulus processors implements nonlinear transformations of multiple temporal or spatio-temporal signals such as spike trains or auditory and v... | 25,175,020 | [
-0.002077007,
0.1635625,
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-0.02020844,
0.1502642,
-0.6248274,
-0.3819216,
0.05583364,
0.2688981,
-0.08183881,
-0.1324362,
-0.2793699,
0.03104522,
-0.1720257,
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0.03892558,
-0.2867318,
0.1977126,
-0.1907221,
-0.07565787,
0.2359369,
0.231811,
-0.1125972... |
Reduced-intensity conditioning for hematopoietic cell transplantation of chronic granulomatous disease. | Hematopoietic cell transplantation (HCT) is the only available curative therapy for chronic granulomatous disease (CGD), but its use is limited by transplant-related mortality (TRM) in patients who often come to transplant with existing infections or organ dysfunction. Reduction in the intensity of the preparative regi... | 25,175,046 | [
-0.1389804,
-0.1588399,
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0.01302141,
0.1041324,
0.08486122,
0.04892346,
0.01130255,
0.09116171,
0.07420313,
0.1757184,
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0.1805211,
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-0.1990797,
0.2479342,
0.1657144,
-0.0132395,
0.06343995,
0.170994,
... |
The heart and brain imaging in lone atrial fibrillation - are we surprised? | "Lone" atrial fibrillation (AF) is generally used to refer to patients with AF in the absence of structural heart disease. When the decision for oral anticoagulation is discussed, "lone" AF refers to patients who do not have established stroke risk factors. Imaging is often used to rule out structural heart disease, e.... | 25,175,092 | [
-0.2598052,
0.2996748,
0.1307321,
-0.1705924,
-0.01867563,
-0.2875829,
0.1723353,
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-0.2097291,
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0.4400304,
-0.03611673,
-0.5161722,
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0.1143767,
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0.4474843,
0.2483364,
0.2438077,
0.06856194,
-0.04680129,
-0.1134351... |
Integrated collaborative care for major depression comorbid with a poor prognosis cancer (SMaRT Oncology-3): a multicentre randomised controlled trial in patients with lung cancer. | The management of depression in patients with poor prognosis cancers, such as lung cancer, creates specific challenges. We aimed to assess the efficacy of an integrated treatment programme for major depression in patients with lung cancer compared with usual care. Symptom Management Research Trials (SMaRT) Oncology-3 i... | 25,175,097 | [
0.1085096,
0.226685,
-0.09873334,
-0.3591006,
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0.01135199,
0.1825641,
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-0.1389578,
0.2084793,
0.04958729,
0.2979749,
-0.2189331,
0.4052657,
-0.1782884,
... |
Late-onset congenital adrenal hyperplasia with Cushing syndrome. | Although hirsutism is classically part of the clinical presentation of polycystic ovarian syndrome (PCOS), congenital adrenal hyperplasia and Cushing's syndrome (CS), CS associated with underlying late-onset congenital adrenal hyperplasia (LCAH) in an adult has not been previously reported. We herein present the case o... | 25,175,129 | [
-0.1023771,
0.0534123,
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0.1368816,
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-0.1293762,
0.05076264,
0.1177074,
0.08195237,
0.1460683,
0.5931947,
-0.1832152,
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0.05358269,
0.2293955,
-0.08901507,
0.04574645,
0.1480039,
-0.4224498,
... |
Hypopituitarism possibly due to lymphocytic hypophysitis in a patient with type 1 diabetes. | Hypopituitarism often develops insidiously, and undiagnosed hypopituitarism can influence the glycemic profile of patients with type 1 diabetes. We herein report the case of a 49-year-old man with type 1 diabetes and Hashimoto's thyroiditis who experienced an unexplained improvement in his glycemic level and recurrent ... | 25,175,130 | [
-0.1276619,
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0.1784425,
0.2483241,
0.07710838,
0.1381738,
0.2684464,
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0.2338911,
0.08671538,
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0.1019021,
0.1414615,
-0.4372673,
0.09762354,
0.2227856,
-0.3958131,
-... |
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