title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death. | The synthesis and bio-evaluation of naturally occurring boswellic acids (BAs) as an alternate CAP for the design of new HDAC inhibitors is described. All the compounds were screened against a panel of human cancer cell lines to identify leads, which were subsequently examined for their potential to inhibit HDACs. The i... | 25,176,189 | [
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The discovery of potent glycine transporter type-2 inhibitors: design and synthesis of phenoxymethylbenzamide derivatives. | We describe the discovery of phenoxymethylbenzamide derivatives as a novel class of glycine transporter type-2 (GlyT-2) inhibitors. We found hit compound 1 (human GlyT-2, IC50=4040 nM) in our library and converted its 1-(1-(naphthalen-2-ylmethyl)piperidin-4-yl)pyrrolidin-3-yl group to an 1-(N,N-dimethylaminopropyl)pipe... | 25,176,190 | [
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Solitary metastasis of renal cell carcinoma in infratemporal fossa. | Renal cell carcinoma can recur at any time after nephrectomy, and it is not unusual to detect late metastases even decades after surgical excision of the primary tumor. Despite being infrequently reported, head and neck metastases may be linked to renal cell carcinoma in up to 15% of cases. We present an unusual case o... | 25,176,195 | [
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Enhancing the photoluminescence of 1-(naphthalene-1-yl)-2,4,5-triphenyl-1H-imidazole anchored to superparamagnetic nanoparticles. | Synthesis and characterization of 1-(naphthalene-1-yl)-2,4,5-triphenyl-1H-imidazole has been carried out by spectral studies. The synthesized phosphated imidazole and phosphated imidazole bound magnetic nanoparticles were characterized using fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy ... | 25,176,199 | [
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[Prevalence and features of pathogenic bacteria in the department of hematology without bone marrow transplantation in Peking Union Medical College Hospital from 2010 to 2012]. | To investigate the incidence, pathogens, and clinical features of infection in consecutive cases from 2010 to 2012 in Peking Union Medical College Hospital. The incidence, pathogen, treatment, and outcomes of patients with hematological diseases who had positive findings of bacterium in their samples from 2010 to 2012 ... | 25,176,215 | [
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l-3-n-Butylphthalide attenuates β-amyloid-induced toxicity in neuroblastoma SH-SY5Y cells through regulating mitochondrion-mediated apoptosis and MAPK signaling. | Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid-β protein (Aβ), the hallmark of AD, invokes a cascade of mitochondrial dysfunction and eventually leads to neuronal death. l-3-n-Butylphthalide (l-NBP) has shown the potent neuroprotective effects in stroke and AD animal models. The present st... | 25,176,222 | [
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Formulation and stability evaluation of immediate release antioxidant tablet. | Oxidative stress plays an important part in the development of human diseases. Pharmaceutical strategies are required to be work out in order to fight against such oxidative damages. Designing of new formulations that can protect human beings from the undesirable effects, consequence of oxidative stress, the crucial ce... | 25,176,233 | [
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Drug utilization evaluation of meropenem and correlation of side effects with renal status of patients in a teaching based hospital. | Meropenem is a restricted, broad spectrum and expensive antibiotic. The major consequences of irrational use of restricted antibiotics are increase drug resistance and drug expenditure. The use of antibiotics, specifically restricted antibiotics, must be monitored continuously to increase its adherence to the standard ... | 25,176,244 | [
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Anxiolytic and hyperlocomotive effects of aqueous extract of Nigella sativa L. seeds in rats. | Use of the herbal drugs increasing all over the world due to its minimum side effect. Nigella sativa black seeds used in folk medicine for the promotion of good health and for the treatment of many diseases .The present study is designed to investigate the neurochemical and behavioral effect of aqueous extract of Nigel... | 25,176,249 | [
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Annona squamosa Linn: cytotoxic activity found in leaf extract against human tumor cell lines. | Cancer is a common cause of death in human populations. Surgery, chemotherapy and radiotherapy still remain the corner stone of treatment. However, herbal medicines are gaining popularity on account of their lesser harmful side effects on non-targeted human cells and biological environment. Annona squamosa Linn is a co... | 25,176,251 | [
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Diallyl disulfide selectively causes checkpoint kinase-1 mediated G2/M arrest in human MGC803 gastric cancer cell line. | Previous studies have shown that diallyl disulfide (DADS), a naturally occurring anticancer agent in garlic, arrested human gastric cancer cells (MGC803) in the G2/M phase of the cell cycle. Due to the importance of cell cycle redistribution in DADS-mediated anticarcinogenic effects, we investigated the role of checkpo... | 25,176,258 | [
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Nitrate removal with lateral flow sulphur autotrophic denitrification reactor. | An innovative lateral flow sulphur autotrophic denitrification (LFSAD) reactor was developed in this study; the treatment performance was evaluated and compared with traditional sulphur/limestone autotrophic denitrification (SLAD) reactor. Results showed that nitrite accumulation in the LFSAD reactor was less than 1.0 ... | 25,176,303 | [
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Production and characterization of polypropylene composites filled with glass fibre recycled from pyrolysed waste printed circuit boards. | Waste printed circuit boards (WPCBs) are composed of nearly 70% non-metals, which are generally recycled as low-value filling materials or even directly dumped in landfills. In this study, polypropylene (PP) composites reinforced by recycled pure glass fibres (RGF) from pyrolysed WPCBs were successfully produced. The m... | 25,176,309 | [
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Bioluminescence-based measurement of viability of Pseudomonas aeruginosa ATCC 9027 harbouring plasmid-based lux genes under the control of constitutive promoters. | Detection of microbial contamination in pharmaceuticals, food and cosmetics has been problematic for several decades. Numerous investigations highlight the urgency for novel methods; development of bioluminescent constructs allows real-time monitoring, rapid analysis and high-throughput screening of products. Microbial... | 25,176,324 | [
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Stem cell-based therapies for cancer treatment: separating hope from hype. | Stem cell-based therapies are emerging as a promising strategy to tackle cancer. Multiple stem cell types have been shown to exhibit inherent tropism towards tumours. Moreover, when engineered to express therapeutic agents, these pathotropic delivery vehicles can effectively target sites of malignancy. This perspective... | 25,176,333 | [
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DICER1: mutations, microRNAs and mechanisms. | Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena that are profoundly embedded in cancer gene networks. Most recently, both germline and somatic mutations in DICER1 have been identified in diverse types of cancer. Although some of the mutations clearly reduce the dosage of thi... | 25,176,334 | [
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Clinical utility of dipeptidyl peptidase-4 inhibitors: a descriptive summary of current efficacy trials. | To review efficacy and safety data of dipeptidyl peptidase-4 inhibitors used in treatment of patients with type 2 diabetes mellitus. A search of MEDLINE®/PubMed®, a service of the National Library of Medicine of the National Institutes of Health as well as of the original publications of individual trials with dipeptid... | 25,176,337 | [
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Seasonal changes in Sphagnum peatland testate amoeba communities along a hydrological gradient. | Testate amoebae are an abundant and functionally important group of protists in peatlands, but little is known about the seasonal patterns of their communities. We investigated the relationships between testate amoeba diversity and community structure and water table depth and light conditions (shading vs. insolation) ... | 25,176,338 | [
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Useful ethnophytomedicinal recipes of angiosperms used against diabetes in South East Asian Countries (India, Pakistan & Sri Lanka). | This paper is based on data recorded from various literatures pertaining to ethnophytomedicinal recipes used against diabetes in South East Asia (India, Pakistan and Srilanka). Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. In total 419 useful phytorecipes of 270 ... | 25,176,368 | [
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Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers. | The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. Thirty-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate times. Drug concentrations of fexofenadine were measured by a LC/MS/MS method. Non-compartmental models wer... | 25,176,380 | [
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jvenn: an interactive Venn diagram viewer. | Venn diagrams are commonly used to display list comparison. In biology, they are widely used to show the differences between gene lists originating from different differential analyses, for instance. They thus allow the comparison between different experimental conditions or between different methods. However, when the... | 25,176,396 | [
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Leishmania amazonensis: Increase in ecto-ATPase activity and parasite burden of vinblastine-resistant protozoa. | Leishmania amazonensis is a protozoan parasite that induces mucocutaneous and diffuse cutaneous lesions upon infection. An important component in treatment failure is the emergence of drug-resistant parasites. It is necessary to clarify the mechanism of resistance that occurs in these parasites to develop effective dru... | 25,176,449 | [
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Health care characteristics of basal cell carcinoma in Germany: the role of insurance status and socio-demographic factors. | In Germany population-based data on health care of basal cell carcinoma (BCC) are rare. To analyze the relationship between socio-demographic and regional factors, health insurance status and clinical features of BCC. Data base was from a nationwide dermatopathology laboratory. All consecutive excisions from 2010 were ... | 25,176,460 | [
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Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome. | Increased adrenocortical production appears to be associated with acne and hirsutism in acne and polycystic ovary syndrome (PCOS). However, the aetiological role of androgens in the pathogenesis of acne per se is far from being clear. We aimed to evaluate adrenocortical function in women with post-adolescent severe acn... | 25,176,476 | [
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Evaluation of lead recovery efficiency from waste CRT funnel glass by chlorinating volatilization process. | The current study was carried out to develop a novel process, namely chloride volatilization procedure for lead recovery from waste cathode ray tube (CRT) funnel glass. In the recovery system, the glass powder was first compressed into cylindrical pellet homogeneously with chlorinating agents, and then subjected to the... | 25,176,480 | [
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Recovery of soluble chloride salts from the wastewater generated during the washing process of municipal solid wastes incineration fly ash. | Water washing is widely used as the pretreatment method to treat municipal solid waste incineration fly ash, which facilitates the further solidification/stabilization treatment or resource recovery of the fly ash. The wastewater generated during the washing process is a kind of hydrosaline solution, usually containing... | 25,176,491 | [
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Femtosecond spectroscopy and TD-DFT calculations of CuCl4(2-) excited states. | Photoinduced processes of tetrahexylammonium tetrachlorocuprate [(C6H13)4N]2Cu(II)Cl4 in chloro-organic solvents were investigated by steady state photolysis and femtosecond transient absorption spectroscopy. The quantum yield of photoreduction of CuCl4(2-) was estimated to be about 1%; the process resulted in the form... | 25,176,502 | [
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[Clinical burden of multi-cause and pneumococcal pneumonia, meningitis, and septicemia in Hungary. Results of a retrospective study (2006-2011)]. | Assessment of the impact of pneumococcal conjugate vaccines on the burden of pneumonia, meningitis, and septicemia in Hungary is limited. The aim of this retrospective study was to quantify rates of hospitalized multi-cause and pneumococcal pneumonia, meningitis, and septicemia in all age groups in Hungary between 2006... | 25,176,517 | [
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Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. | Despite initial reports of a decline in use in the early 2000s, methamphetamine remains a significant public health concern with known neurotoxic and neurocognitive effects to the user. The goal of this review is to update the literature on methamphetamine use and addiction since its assent to peak popularity in 1990s.... | 25,176,528 | [
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China's distinctive engagement in global health. | China has made rapid progress in four key domains of global health. China's health aid deploys medical teams, constructs facilities, donates drugs and equipment, trains personnel, and supports malaria control mainly in Africa and Asia. Prompted by the severe acute respiratory syndrome (SARS) outbreak in 2003, China has... | 25,176,550 | [
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Suspected iatrogenic ureteric injury: an approach to diagnostic imaging. | Iatrogenic ureteric injury (IUI) is the leading cause of ureteric trauma and a complication of major abdominal and pelvic surgery. IUI carries significant morbidity and mortality, which can be further compounded by delayed diagnosis due to its non-specific clinical presentation. We review ureteric anatomy, types of IUI... | 25,176,585 | [
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Inflammatory mediators, muscle and functional performance of community-dwelling elderly women. | The purpose of this study was to investigate the correlation and association between inflammatory mediators and muscle and functional performance in elderly women. We conducted a cross-sectional study. Plasma concentrations of interleukin-6 (IL-6) and soluble receptor for tumor necrosis factor alpha (sTNFR1) were deter... | 25,176,589 | [
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Mechanism of chemical degradation and determination of solubility by kinetic modeling of the highly unstable sesquiterpene lactone nobilin in different media. | The objective of this work was first to investigate the chemical degradation of the sesquiterpene lactone nobilin and determine its solubility under conditions of concurrent degradation for partially amorphous starting material; second, to determine the effect of biorelevant media used in the in vitro measurement of in... | 25,176,605 | [
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Failsafe mechanisms couple division and DNA replication in bacteria. | The past 20 years have seen tremendous advances in our understanding of the mechanisms underlying bacterial cytokinesis, particularly the composition of the division machinery and the factors controlling its assembly [1]. At the same time, we understand very little about the relationship between cell division and other... | 25,176,632 | [
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Rewiring Mid1p-independent medial division in fission yeast. | Correct positioning of the cell division machinery is key to genome stability. Schizosaccharomyces pombe is an attractive organism to study cytokinesis as it, like higher eukaryotes, divides using a contractile actomyosin ring. In S. pombe, many actomyosin ring components assemble at the medial cortex into node-like st... | 25,176,634 | [
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The effect of repeated administrations of llama ovulation-inducing factor (OIF/NGF) during the peri-ovulatory period on corpus luteum development and function in llamas. | The objective of the study was to test the hypothesis that repeated administrations of OIF/NGF during the peri-ovulatory period (pre-ovulatory, ovulatory, early post-ovulatory), will enhance the luteotrophic effect in llamas. Female llamas were examined daily by transrectal ultrasonography in B- and Doppler-mode using ... | 25,176,642 | [
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High prevalence of deficient mismatch repair phenotype and the V600E BRAF mutation in elderly patients with colorectal cancer. | Colorectal cancer (CRC) occurs mostly in the elderly. However, the biology of CRC in elderly has been poorly studied. This study examined the prevalence of deficient mismatch repair phenotype (dMMR) and BRAF mutations according to age. MMR phenotype was prospectively determined by molecular analysis in patients of all ... | 25,176,643 | [
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Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia. | The majority of hypertriglyceridemias are diagnosed as familial combined hyperlipidemia (FCHL) and primary isolated hypertriglyceridemias. The contribution of common genetic variants in primary hypertriglyceridemias and the genetic difference between FCHL and isolated hypertriglyceridemias have not been thoroughly exam... | 25,176,936 | [
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Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry). | The EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot) provides systematic collection of contemporary data regarding the management and treatment of 3119 subjects with AF from 9 member European Society of Cardiology (ESC) countries. In this analysis, we report the devel... | 25,176,940 | [
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Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial. | The neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-controlled trial designed to evaluate whether a single dose of vagal nerve stimulation (VNS) would attenuate cardiac remodelling, improve cardiac function and increase exercise capacity in symptomatic heart failure patients with severe left ... | 25,176,942 | [
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MicroRNAs as non-invasive biomarkers of heart transplant rejection. | Rejection is one of the major causes of late cardiac allograft failure and at present can only be diagnosed by invasive endomyocardial biopsies. We sought to determine whether microRNA profiling could serve as a non-invasive biomarker of cardiac allograft rejection. We included 113 heart transplant recipients from four... | 25,176,944 | [
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Depression and anxiety in patients with COPD. | Under-recognised and untreated depression and anxiety symptoms have deleterious effects on physical functioning and social interaction increasing fatigue and healthcare utilisation in patients with chronic obstructive pulmonary disease (COPD). Depression and anxiety are challenging to identify and treat because their s... | 25,176,970 | [
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Current concepts: host-pathogen interactions in cystic fibrosis airways disease. | Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begu... | 25,176,968 | [
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Survival analysis in hematologic malignancies: recommendations for clinicians. | The widespread availability of statistical packages has undoubtedly helped hematologists worldwide in the analysis of their data, but has also led to the inappropriate use of statistical methods. In this article, we review some basic concepts of survival analysis and also make recommendations about how and when to perf... | 25,176,982 | [
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Multiple Bragg reflection by a thick mosaic crystal. | Symmetric Bragg-case reflections from a thick, ideally imperfect, crystal slab are studied mostly by analytical means. The scattering transfer function of a thin mosaic layer is derived and brought into a form that allows for analytical approximations or easy quadrature. The Darwin-Hamilton equations are generalized, l... | 25,176,991 | [
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[Glucocorticoid and Bone. Efficacy of active vitamin D on glucocorticoid-induced osteoporosis]. | Active vitamin D is a second line treatment followed by bisphosphonate in the Japanese guideline of glucocorticoid-induced osteoporosis (GIO) . Although it shows relatively mild but significant effect on BMD and fracture prevention, it is utilized as combination therapy with bisphosphonate. Vitamin D is recommended for... | 25,177,012 | [
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Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones. | Fatty acid synthase (FASN) is the enzyme that synthesizes fatty acids de novo in human cells. Although FASN is generally expressed at low levels in most normal tissues, its expression is highly upregulated in many cancers. Consistent with this notion, inhibition of FASN activity has demonstrated potential to halt proli... | 25,177,021 | [
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Coibanoles, a new class of meroterpenoids produced by <i>Pycnoporus sanguineus.</i> | Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus <iPycnoporus sanguineus</i. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and... | 25,177,062 | [
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Varicella and herpes zoster hospitalizations before and after implementation of one-dose varicella vaccination in Australia: an ecological study. | To examine trends in varicella and herpes zoster (HZ) hospitalization following the availability and subsequent National Immunization Programme funding of one-dose varicella vaccination in Australia. Varicella vaccination coverage for children born between 2001 and 2009 was obtained from the Australian Childhood Immuni... | 25,177,074 | [
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Outcomes of transjugular intrahepatic portosystemic shunts for ascites. | Refractory ascites represents a devastating complication of portal hypertension. Transjugular intrahepatic portosystemic shunt (TIPS) is an efficacious option for patients for whom transplant is not an immediate option. Techniques to optimize the hepatic venous pressure gradient and the use of covered stents have reduc... | 25,177,085 | [
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The history and future of transjugular intrahepatic portosystemic shunt: food for thought. | The origins of transjugular intrahepatic portosystemic shunt (TIPS) date back to the 1960s with inadvertent portal access during the early years of transjugular cholangiography. TIPS is now the most frequently performed portal hypertension decompressive procedure performed by interventional radiologists, and has become... | 25,177,087 | [
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The influence of karate practice level and sex on physiological and perceptual responses in three modern karate training modalities. | The aim of the present study was to examine the influence of karate practice level (national vs international level) and sex (women vs men) on physiological and perceptual responses in three modern karate training modalities (tactical-technical (TT), technical-development (TD), and randori). The study included 18 karat... | 25,177,098 | [
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The acute effect of whole body vibration training on flexibility and explosive strength of young gymnasts. | The purpose of this study was to examine the acute effect of a single bout of whole body vibration (WBV) on flexibility and explosive strength of lower limbs in young artistic gymnasts. Thirty-two young competitive gymnasts volunteered to participate in this study, and were allocated to either the vibration group or tr... | 25,177,103 | [
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Role of prosthodontist in forensic odontology. A literature review. | Dental identification assumes a primary role in the identification of remains when postmortem changes, traumatic tissue injury, or lack of a fingerprint record invalidate the use of visual or fingerprint methods. The most common role of the forensic dentist is the identification of deceased individuals. Forensic identi... | 25,177,136 | [
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Radiomorphometric analysis of frontal sinus for sex determination. | Sex determination of unknown individuals carries crucial significance in forensic research, in cases where fragments of skull persist with no likelihood of identification based on dental arch. In these instances sex determination becomes important to rule out certain number of possibilities instantly and helps in estab... | 25,177,140 | [
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0.2484594,
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0.5025955,... |
Role of bite mark characteristics and localizations in finding an assailant. | The location, size, and number of bite marks can be used as a beneficial indicator of the crime type and feasible group of suspects. This study aims to present information about the bite mark locations, the bite mark characteristics, and the perpetrator's profile based on three cases which were carried out by the same ... | 25,177,145 | [
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... |
Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca(2+) Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells. | Flavonoids have an ability to suppress various ion channels. We determined whether one of flavonoids, cyanidin-3-glucoside, affects adenosine 5'-triphosphate (ATP)-induced calcium signaling using digital imaging methods for intracellular free Ca(2+) concentration ([Ca(2+)]i), reactive oxygen species (ROS) and mitochond... | 25,177,161 | [
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Comparison of oxygen consumption in rats during uphill (concentric) and downhill (eccentric) treadmill exercise tests. | The study of the physiological adaptations of skeletal muscle in response to eccentric (ECC) contraction is based on protocols in which exercise intensities are determined relative to the concentric (CON) reference exercise (as percentage of the CON maximal oxygen consumption, or VO2max). In order to use similar exerci... | 25,177,200 | [
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0.016... |
Temperature Control of Hypertensive Rats during Moderate Exercise in Warm Environment. | The control of body temperature in Spontaneously Hypertensive Rat (SHR) subjected to exercise in warm environment was investigated. Male SHR and Wistar rats were submitted to moderate exercise in temperate (25°C) and warm (32°C) environments while body and tail skin temperatures, as well as oxygen consumption, were reg... | 25,177,201 | [
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Glucomannan-mediated facile synthesis of gold nanoparticles for catalytic reduction of 4-nitrophenol. | A facile one-pot approach for synthesis of gold nanoparticles with narrow size distribution and good stability was presented by reducing chloroauric acid with a polysaccharide, konjac glucomannan (KGM) in alkaline solution, which is green and economically viable. Here, KGM served both as reducing agent and stabilizer. ... | 25,177,220 | [
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Engineering optical properties of gold-coated nanoporous anodic alumina for biosensing. | The effect in the Fabry-Pérot optical interferences of nanoporous anodic alumina films coated with gold is studied as a function of the porosity and of the gold thickness by means of reflectance spectroscopy. Samples with porosities between 14 and 70% and gold thicknesses (10 and 20 nm) were considered. The sputtering ... | 25,177,224 | [
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Photonic porous silicon as a pH sensor. | Chronic wounds do not heal within 3 months, and during the lengthy healing process, the wound is invariably exposed to bacteria, which can colonize the wound bed and form biofilms. This alters the wound metabolism and brings about a change of pH. In this work, porous silicon photonic films were coated with the pH-respo... | 25,177,227 | [
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Microinvasive cervical squamous cell carcinoma in Slovenia during the period 2001-2007. | Microinvasive squamous cell carcinoma (MISCC) comprises a significant portion of all cervical cancers in Slovenia. Criteria of carcinomatous invasion are well described in the literature, however histopathological assessment of MISCC is difficult, because morphological characteristics can overlap with cervical intraepi... | 25,177,242 | [
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MRI to delineate the gross tumor volume of nasopharyngeal cancers: which sequences and planes should be used? | Magnetic resonance imaging (MRI) has been found to be better than computed tomography for defining the extent of primary gross tumor volume (GTV) in advanced nasopharyngeal cancer. It is routinely applied for target delineation in planning radiotherapy. However, the specific MRI sequences/planes that should be used are... | 25,177,248 | [
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The roles of innate lymphoid cells in the development of asthma. | Asthma is a common pulmonary disease with several different forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in association with allergen sensitization and adaptive immunity. Recently, there have b... | 25,177,249 | [
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Urinary excretion of melatonin and association with breast cancer: meta-analysis and review of the literature. | Melatonin is an endocrine hormone secreted by the pineal gland during night hours that provides several biological functions in the circadian rhythm of humans. Due to anti-estrogenic properties, melatonin is considered to exhibit a protective role against the development of breast cancer (BC). Moreover, disruption of m... | 25,177,260 | [
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Speed accuracy trade-off under response deadlines. | Perceptual decision making has been successfully modeled as a process of evidence accumulation up to a threshold. In order to maximize the rewards earned for correct responses in tasks with response deadlines, participants should collapse decision thresholds dynamically during each trial so that a decision is reached b... | 25,177,265 | [
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... |
Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus. | It is becoming increasingly clear that leptin is not only a hormone regulating energy homeostasis but also a neurotrophic factor impacting a number of brain regions, including the hippocampus. Although leptin promotes the development of GABAergic transmission in the hypothalamus, little is known about its action on the... | 25,177,272 | [
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Multiple monoaminergic modulation of posturo-locomotor network activity in the newborn rat spinal cord. | Studies devoted to understanding locomotor control have mainly addressed the functioning of the neural circuits controlling leg movements and relatively little is known of the operation of networks that activate trunk muscles in coordination with limb movements. The aim of the present work was (1) to identify the exoge... | 25,177,275 | [
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Combining segmentation and attention: a new foveal attention model. | Artificial vision systems cannot process all the information that they receive from the world in real time because it is highly expensive and inefficient in terms of computational cost. Inspired by biological perception systems, artificial attention models pursuit to select only the relevant part of the scene. On human... | 25,177,289 | [
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Fast convergence of learning requires plasticity between inferior olive and deep cerebellar nuclei in a manipulation task: a closed-loop robotic simulation. | The cerebellum is known to play a critical role in learning relevant patterns of activity for adaptive motor control, but the underlying network mechanisms are only partly understood. The classical long-term synaptic plasticity between parallel fibers (PFs) and Purkinje cells (PCs), which is driven by the inferior oliv... | 25,177,290 | [
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Neurobiology of cognitive remediation therapy for schizophrenia: a systematic review. | Cognitive impairment is an important aspect of schizophrenia, where cognitive remediation therapy (CRT) is a promising treatment for improving cognitive functioning. While neurobiological dysfunction in schizophrenia has been the target of much research, the neural substrate of cognitive remediation and recovery has no... | 25,177,300 | [
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Gender Differences in Current Received during Transcranial Electrical Stimulation. | Low current transcranial electrical stimulation (tCS) is an effective but somewhat inconsistent tool for augmenting neuromodulation. In this study, we used 3D MRI guided electrical transcranial stimulation modeling to estimate the range of current intensities received at cortical brain tissues. Combined T1, T2, and pro... | 25,177,301 | [
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The efficacy of the enhanced Aussie Optimism Positive Thinking Skills Program in improving social and emotional learning in middle childhood. | The aim of the current study was to investigate the effects of the modified and enhanced Aussie Optimism Positive Thinking Skills Program (AO-PTS) on Year 4 and 5 children's social and emotional learning (SEL) skills. AO-PTS is a universal-school based program that is implemented by class teachers as part of regular sc... | 25,177,310 | [
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Dengue serotype cross-reactive, anti-e protein antibodies confound specific immune memory for 1 year after infection. | Dengue virus has four serotypes and is endemic globally in tropical countries. Neither a specific treatment nor an approved vaccine is available, and correlates of protection are not established. The standard neutralization assay cannot differentiate between serotype-specific and serotype cross-reactive antibodies in p... | 25,177,321 | [
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The role of auxin transporters in monocots development. | Auxin is a key regulator of plant growth and development, orchestrating cell division, elongation and differentiation, embryonic development, root and stem tropisms, apical dominance, and transition to flowering. Auxin levels are higher in undifferentiated cell populations and decrease following organ initiation and ti... | 25,177,324 | [
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To respond or not to respond, the recurring question in plant mechanosensitivity. | In nature, terrestrial plants experience many kinds of external mechanical stimulation and respond by triggering a network of signaling events to acclimate their growth and development. Some environmental cues, especially wind, recur on time scales varying from seconds to days. Plants thus have to adapt their sensitivi... | 25,177,327 | [
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Prevalence and covariates of elevated depressive symptoms in rural memory clinic patients with mild cognitive impairment or dementia. | To estimate the prevalence, severity, and covariates of depressive symptoms in rural memory clinic patients diagnosed with either mild cognitive impairment (MCI) or dementia. In a cross-sectional study of 216 rural individuals who attended an interdisciplinary memory clinic between March 2004 and July 2012, 51 patients... | 25,177,329 | [
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Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study. | We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD) from the Clinical Research Center for Dementia of South Korea (CREDOS)-FTD registry. A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive... | 25,177,333 | [
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The role of glucagon on type 2 diabetes at a glance. | The opposite effects of insulin and glucagon in fuel homeostasis, the paracrine/endocrine inhibitory effects of insulin on glucagon secretion and the hyperglucagonemia in the pathogenesis of type 2 diabetes (T2D) have long been recognized. Inappropriately increased alpha-cell function importantly contributes to hypergl... | 25,177,371 | [
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... |
Prognostic Value of Metabolic Tumor Volume Estimated by (18) F-FDG Positron Emission Tomography/Computed Tomography in Patients with Diffuse Large B-Cell Lymphoma of Stage II or III Disease. | The purpose of this study was to evaluate the prognostic value of metabolic tumor volume (MTV) measured by (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab-containing immunochemotherapy. Patients with new... | 25,177,375 | [
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Brain ultrasound in Canavan disease. | Canavan disease (MIM 271900) is a rare autosomal recessive leukodystrophy due to mutations in the ASPA gene (MIM 608034) and characterized by a clinical onset at 3-5 months of life, macrocephaly and poor head control, weak cry and suck, development regression and hypotonia. Here, we report cranial ultrasound findings a... | 25,177,395 | [
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0.3653221,
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0.07325189,
0.04... |
Fusion imaging for intra-operative ultrasound-based navigation in neurosurgery. | The major shortcoming of image-guided navigation systems is the use of presurgically acquired image data, which does not account for intra-operative changes such as brain shift, tissue deformation and tissue removal occurring during the surgical procedure. Intra-operative ultrasound (iUS) is becoming widely used in neu... | 25,177,400 | [
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0.3792222,
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0.04974547,
-0.0811573,
0.1772871,
0.1944076,
-0.0108658,
-0.3553337,
-0.02656109,
-0.7580038,
-0.4833583,
0.1033731,
-0.2436246,
0.1891204,
-0.462608,
-0.4886641,
0.05695714,
0.3009667,
-0.08658525,
... |
Health complaints and use of medicines among adolescents in Malta. | To investigate self-reported health complaints and the use of medicines among adolescents in Malta. A self-administered questionnaire was used to survey self-reported health complaints, the use and the sources of medicines that had been accessed, during the preceding 3 months among adolescents attending secondary schoo... | 25,177,408 | [
-0.2829151,
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0.3425059,
-0.5207344,
0.2392103,
0.4730333,
0.04334204,
-0.3025678,
0.2... |
Invasive fungal sinusitis of the sphenoid sinus. | This study was conducted to present the clinical outcome of invasive fungal sinusitis of the sphenoid sinus and to analyze clinical factors influencing patient survival. A retrospective review of 12 cases of invasive fungal sphenoiditis was conducted. Cases were divided into acute fulminant invasive fungal spheonoidits... | 25,177,433 | [
-0.2141593,
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-0.1219699,
... |
Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells. | Delphinidin is one of the anthocyanidins. It is believed to have anti-inflammatory property including antioxidant, antiangiogenic, and anti-cancer properties. However, the anti-inflammatory effect of delphinidin in mucin-producing human airway epithelial cells has not been determined. Therefore, this study was conducte... | 25,177,436 | [
-0.3602686,
-0.3105125,
0.139236,
0.05725004,
0.01516417,
0.1183164,
-0.3937671,
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0.03097224,
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0.165382,
0.1155712,
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-0.10... |
Evaluation of femoral neck bone mineral density and radiographic hand and knee osteoarthritis in a Korean elderly population. | Reports on the relationship between osteoporosis and osteoarthritis (OA) have tended to disagree, especially in non-weight bearing joints such as the hand joints. We aimed to investigate the relationship between bone mineral density (BMD) and hand and knee OA in a general Korean elderly population. We evaluated femur n... | 25,177,462 | [
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-0.08409037,
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0.... |
Gap comparison between single crown and three-unit bridge zirconia substructures. | To compare marginal and internal gaps of zirconia substructure of single crowns with those of three-unit fixed dental prostheses. Standardized Co-Cr alloy simulated second premolar and second molar abutments were fabricated and subsequently duplicated into type-III dental stone for working casts. After that, all zircon... | 25,177,467 | [
0.1135599,
0.3253228,
0.05398981,
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0.1135602,
0.06219119,
0.2491812,
0.1855992,
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0.03249133,
0.140682,
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-0.7016371,
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0.189098,
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-0.1761399,
0.252292,
-0.0005135616,
0.01670241,
... |
The effect of repeated firings on the color change and surface roughness of dental ceramics. | The color of the ceramic restorations is affected by various factors such as brand, thickness of the layered the ceramic, condensation techniques, smoothness of surface, number of firings, firing temperature and thickness of dentin. The aim of this study was to evaluate the color change and surface roughness in dental ... | 25,177,475 | [
0.07292657,
0.438052,
0.0757881,
0.1501153,
0.1011811,
-0.1076142,
0.02205511,
0.3035349,
0.2699723,
0.1322714,
0.2306265,
-0.07238328,
-0.1803939,
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0.1030719,
0.009876437,
-0.2874869,
-0.00495562,
0.1374408,
0.2934588,
-0.1455025,
0.... |
Interfacial Bioorthogonal Cross-Linking. | Described herein is interfacial bioorthogonal cross-linking, the use of bioorthogonal chemistry to create and pattern biomaterials through diffusion-controlled gelation at the liquid-gel interface. The basis is a rapid (<ik</i<sub2</sub 284000 M<sup-1</sup s<sup-1</sup) reaction between strained <itrans</i-cyclooctene ... | 25,177,528 | [
-0.190087,
-0.2792462,
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0.09985579,
0.03055828,
0.6456849,
0.1825484,
-0.0357708,
0... |
Scaling of olfactory antennae of the terrestrial hermit crabs Coenobita rugosus and Coenobita perlatus during ontogeny. | Although many lineages of terrestrial crustaceans have poor olfactory capabilities, crabs in the family Coenobitidae, including the terrestrial hermit crabs in the genus Coenobita, are able to locate food and water using olfactory antennae (antennules) to capture odors from the surrounding air. Terrestrial hermit crabs... | 25,177,536 | [
0.02089398,
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0.1985274,
0.2780513,
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0.07789737,
-0.2464416,
0.001635... |
Overexpression of the Aspergillus niger GatA transporter leads to preferential use of D-galacturonic acid over D-xylose. | Pectin is a structural heteropolysaccharide of the primary cell walls of plants and as such is a significant fraction of agricultural waste residues that is currently insufficiently used. Its main component, D-galacturonic acid, is an attractive substrate for bioconversion. The complete metabolic pathway is present in ... | 25,177,540 | [
-0.01611668,
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0.01056358,
0.1004861,
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0.02695826,
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-0.05067656,
0.07699609,
-0.5025716,
0.5220333,
0.7095801,
-0.1588614,... |
Functional expression of dental plaque microbiota. | Dental caries remains a significant public health problem and is considered pandemic worldwide. The prediction of dental caries based on profiling of microbial species involved in disease and equally important, the identification of species conferring dental health has proven more difficult than anticipated due to high... | 25,177,549 | [
-0.05147582,
0.2072085,
-0.01919899,
0.2658794,
-0.1784739,
-0.3313558,
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0.1390655,
-0.006402957,
-0.4311228,
-0.08917886,
-0.3337351,
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-0.07930162,
0.03982711,
-0.3160967,
-0.01476244,
0.1202901,
0.1937863,
-0.2139088,
0.196327,
0.2554582,
-0.2059227... |
Influence of Deep Breathing on Heart Rate Variability in Parkinson's Disease: Co-relation with Severity of Disease and Non-Motor Symptom Scale Score. | Dysautonomia and non-motor symptoms (NMS) in Parkinson's disease (PD) are frequent, disabling and reduce quality of life of patient. There is a paucity of studies on autonomic dysfunction in PD in Indian population. The study aimed to evaluate autonomic dysfunction in PD patients and co-relate the findings with severit... | 25,177,554 | [
-0.1179147,
-0.09469637,
0.1853126,
-0.1525024,
-0.1817728,
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-0.04914871,
-0.2562976,
-0.3524003,
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-0.02713383,
-0.2047526,
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-0.4729459,
0.0325618,
0.06930032,
-0.1762914,
-0.2339637,
0.1294027,
-0... |
Intra articular synovial lipoma of the right tarsometatarsal joint- a rare case report. | Intra articular synovial lipomas are very rare and only few cases have been reported till now. We are reporting a rare case of intra articular synovial lipoma of the tarsometatarsal joint in the right foot in a 38-year-old male who presented with dull aching pain in the plantar aspect of the foot while walking. The les... | 25,177,569 | [
-0.1239295,
-0.06044853,
-0.05147625,
-0.2431442,
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-0.1186069,
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0.1466657,
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0.2215561,
0.001628823,
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-0.2961811,
0.05383657,
-0.1664546,
-0.2343844,
-0.275651,
-0.03875588,
-0.29... |
Risk Factors Assessment of the Difficult Intubation using Intubation Difficulty Scale (IDS). | The major responsibility of anaesthesiologist is to maintain adequate gas exchange in his patients in all circumstances and this require that patency of upper airway is constantly maintained. Problems with upper airway management are among the most frequent causes of anaesthetic mishaps. Using intubation difficulty sca... | 25,177,576 | [
-0.1173677,
-0.09302803,
-0.1798688,
-0.2406874,
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-0.2140661,
-0.300785,
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-0.3149,
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-0.02477338,
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-0.238428,
-0.5641253,
-0.02532852,
-0.06351586,
-0.2750757,
-0.001135004,
-0.1567457,
0.137... |
Epidural anesthesia for caesarean section in a pregnant patient with pituitary macroadenoma. | Anaesthesia for patient with pituitary adenoma posted for non-neurosurgical surgeries is a challenge to the anaesthesiologist with the risk of sudden change in intracranial dynamics during administration of spinal anaesthesia or during stress response of general anaesthesia. There is a chance of increase in tumour size... | 25,177,577 | [
0.0482034,
-0.06087556,
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0.0288942,
-0.4827379,
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0.02985732,
-0.1512499,
0.005942883,
0.02617723,
-0.03438722,
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0.2790118,
0.06053497,
-0.2378831,
-0.1408386,
-0.02361418,
0.06952... |
HIV Associated Sensory Neuropathy. | In the era of highly active antiretroviral therapy, sensory neuropathies have increased in prevalence. We have documented the frequency and profile of the two most common forms of sensory neuropathies associated with Human Immunodeficiency Virus (HIV) infection and looked into clinicoelectrophysiological correlates to ... | 25,177,587 | [
0.01159501,
-0.000903274,
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0.1109276,
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0.1433474,
0.2513127,
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-0.5113255,
0.1978305,
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0.3549244,
-0.4339395,
0.4266321,
0.01907332,
... |
A rare case of vitamin B12 deficiency with ascites. | Vitamin B12 deficiency is widespread than assumed in population. At risk are older people, pregnant women, vegans, patients with renal and intestinal diseases. Vitamin B12 deficiency can present with various hematological, gastrointestinal and neurological manifestations. In the population, the prevalence of vitamin B1... | 25,177,593 | [
-0.3950844,
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-0.07051304,
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0.6282155,
-0.2665865... |
Clinical Profile of Status epilepticus (SE) in Children in a Tertiary Care Hospital in Bihar. | Status epilepticus (SE) is a common, life threatening neurologic disorder that is essentially an acute, prolonged epileptic crisis. SE can represent an exacerbation of a pre-existing seizure disorder, the initial manifestation of a seizure disorder, or an insult other than a seizure disorder. To study the aetiology, cl... | 25,177,613 | [
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0.08058281,
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0.1923039,
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0.4627272,
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0.1822128,
0.1652572,
0.02397127,
-0.10469,
0.2919806,
-0.05887194,
... |
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