title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Hemothorax with a high carbohydrate antigen 19-9 level caused by a bronchogenic cyst. | A 58-year-old man presented with right-sided chest pain. Radiography and computed tomography showed a pleural effusion in the right chest and a mass in the right hilum. Thoracentesis showed a hemothorax. The carbohydrate antigen (CA) 19-9 level in the pleural effusion was very high, requiring differentiation from malig... | 25,175,134 | [
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Loose versus stranded seeds in permanent prostate brachytherapy: dosimetric comparison of intraoperative plans. | To compare target volume coverage and critical organ dosimetry of intraoperative treatment plans for loose seed (LS) and stranded seed (SS) (125)I permanent implants for low and intermediate risk prostate cancer. Two hundred and five patients who underwent permanent seed brachytherapy were included in the study. For pr... | 25,175,151 | [
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Cancer suspicion in general practice, urgent referral and time to diagnosis: a population-based GP survey and registry study. | Many countries have implemented standardised cancer patient pathways (CPPs) to ensure fast diagnosis of patients suspected of having cancer. Yet, studies are sparse on the impact of such CPPs, and few have distinguished between referral routes. For incident cancer patients, we aimed to determine how often GPs suspected... | 25,175,155 | [
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Heptamethoxyflavone, a citrus flavonoid, suppresses inflammatory osteoclastogenesis and alveolar bone resorption. | We examined the effects of heptamethoxyflavone (HMF), a citrus flavonoid on inflammatory bone resorption. HMF suppressed the osteoclast formation and PGE2 production induced by IL-1. In mouse calvarial organ cultures, HMF attenuated the bone resorption elicited by LPS. HMF suppressed bone resorption in the mandibular a... | 25,175,163 | [
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Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models. | Chetomin is a promising molecule with anti-tumor activities in the epipolythiodioxopiperazine family of fungal secondary metabolites; however, strong hydrophobicity has limited its further applications. In this work, chetomin was encapsulated into polymeric micelles to obtain an aqueous formulation, and the chetomin lo... | 25,175,172 | [
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Research on the corrosion resistance and formation of double-layer calcium phosphate coating on AZ31 obtained at varied temperatures. | In this study, the effect of varied processing temperatures on the corrosion resistance and formation of dual-layer calcium phosphate coating on AZ31 was investigated. The microstructure, phase and morphology were characterized by a scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-r... | 25,175,213 | [
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Modified gum arabic cross-linked gelatin scaffold for biomedical applications. | The present work deals with development of modified gum arabic cross-linked gelatin scaffold for cell culture. A new biocompatible scaffold was developed by cross-linking gelatin (Gel) with gum arabic, a polysaccharide. Gum arabic was subjected to periodate oxidation to obtain gum arabic aldehyde (GAA). GAA was reacted... | 25,175,214 | [
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Melt-spun bioactive sutures containing nanohybrids for local delivery of anti-inflammatory drugs. | In this work, a novel concept is introduced in drug-eluting fibres to ensure a good control of drug delivery features and wide applicability to different bioactive compounds. Composite bioactive sutures based on fibre grade poly(ε-caprolactone) (PCL) and loaded with the anti-inflammatory drug Diclofenac (Dic) or a Dic ... | 25,175,217 | [
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Size-dependent cytotoxicity of europium doped NaYF ₄ nanoparticles in endothelial cells. | Lanthanide-doped sodium yttrium fluoride (NaYF4) nanoparticles exhibit novel optical properties which make them be widely used in various fields. The extensive applications increase the chance of human exposure to these nanoparticles and thus raise deep concerns regarding their riskiness. In the present study, we have ... | 25,175,221 | [
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Corrosion behavior and mechanical properties of bioactive sol-gel coatings on titanium implants. | Organic-inorganic hybrid coatings based on zirconia and poly (ε-caprolactone) (PCL) were prepared by means of sol-gel dip-coating technique and used to coat titanium grade 4 implants (Ti-4) in order to improve their wear and corrosion resistance. The coating chemical composition has been analysed by ATR-FTIR. The influ... | 25,175,226 | [
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Preparation of electromechanically active silicone composites and some evaluations of their suitability for biomedical applications. | Some films based on electromechanically active polymer composites have been prepared. Polydimethylsiloxane-α,ω-diols (PDMSs) having different molecular masses (Mv=60 700 and Mv=44 200) were used as matrix in which two different active fillers were incorporated: titanium dioxide in situ generated from its titanium isopr... | 25,175,228 | [
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Production of hydroxyapatite layers on the plasma electrolytically oxidized surface of titanium alloys. | Hydroxyapatite (HA) is a bioactive material that is widely used for improving the osseointegration of titanium dental implants. Titanium can be coated with HA by various methods, such as chemical vapor deposition (CVD), thermal spray, or plasma spray. HA coatings can also be grown on titanium surfaces by hydrothermal, ... | 25,175,246 | [
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Development of thrombus-resistant and cell compatible crimped polyethylene terephthalate cardiovascular grafts using surface co-immobilized heparin and collagen. | Short-term patency of polyethylene terephthalate (PET) cardiovascular grafts is determined mainly by the inherent thrombogenicity and improper endothelialization following grafts implantation. The aim of the present study was to immobilize heparin to develop thrombus resistant grafts. Additionally, collagen was co-immo... | 25,175,248 | [
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Study of biocompatibility of medical grade high nitrogen nickel-free austenitic stainless steel in vitro. | Adverse effects of nickel ions being released into the living organism have resulted in development of high nitrogen nickel-free austenitic stainless steels for medical applications. Nitrogen not only replaces nickel for austenitic structure stability but also improves steel properties. The cell cytocompatibility, bloo... | 25,175,259 | [
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Assessment of respirable crystalline silica analysis using Proficiency Analytical Testing results from 2003-2013. | Analysis of Proficiency Analytical Testing (PAT) results between 2003 and 2013 suggest that the variation in respirable crystalline silica analysis is much smaller today than it was in the period 1990-1998, partly because of a change in sample production procedure and because the colorimetric method has been phased out... | 25,175,284 | [
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Biomedical subjectivities and reproductive assumptions in the CAMELIA clinical trial in Cambodia. | The inclusion of women in clinical trials has raised a variety of ethical and practical issues in their implementation. In the recent CAMELIA clinical trial in Cambodia, the inclusion criteria included a negative pregnancy test and signature of the consent form confirming commitment to double contraceptive use as patie... | 25,175,297 | [
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Caring on the margins of the healthcare system. | This paper addresses the working practices of a mobile mental health outreach team in a large French city, one that 'targets' homeless people with severe psychiatric disorders who are considered 'hard to reach' by the public health authorities and medical services. Analysis of the team's work--where acts of curing and ... | 25,175,298 | [
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Laparoscopic management of bowel endometriosis: resection margins as a predictor of recurrence. | To evaluate possible predictive factors for recurrence after laparoscopic segmental bowel resection for bowel endometriosis. Cohort study. Academic tertiary referral center. 95 symptomatic women with bowel endometriosis who underwent laparoscopic segmental bowel resection at the Endometriosis clinic, University of Bern... | 25,175,300 | [
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The impact of culture on physiological processes of emotion regulation: a comparison of US and Chinese preschoolers. | Cognitive determinants of emotion regulation, such as effortful control, have been hypothesized to modulate young children's physiological response to emotional stress. It is unknown, however, whether this model of emotion regulation generalizes across Western and non-Western cultures. The current study examined the re... | 25,175,305 | [
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Pathogenesis and host defence against Mucorales: the role of cytokines and interaction with antifungal drugs. | Innate immune response, including macrophages, neutrophils and dendritic cells and their respective receptors, plays an important role in host defences against Mucorales with differential activity against specific fungal species, while adaptive immunity is not the first line of defence. A number of endogenous and exoge... | 25,175,306 | [
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Feasibility and efficacy of menu planning combined with individual counselling to improve health outcomes and dietary adherence in people with type 2 diabetes: a pilot study. | The purpose of this study was to test the feasibility and efficacy of implementing a 4-week menu plan combined with individual counselling among people with type 2 diabetes. A 12-week pilot study with a pretest and post-test design was conducted among 15 participants with type 2 diabetes. The menu plan incorporated the... | 25,175,312 | [
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Delivering healthcare services to children with cerebral palsy and their families: a narrative review. | Children with cerebral palsy have complex healthcare needs and often require complex multidisciplinary care. It is important for clinicians to understand which approaches to healthcare service delivery for this population are supported in the literature and how these should be applied in clinical practice. This narrati... | 25,175,322 | [
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Dihydroazulene: from controlling photochromism to molecular electronics devices. | Recent synthetic advances allowing large-scale preparation and systematic functionalization of the dihydroazulene (DHA)-vinylheptafulvene (VHF) photo-/thermoswitch have enabled detailed studies on how to tune optical and switching properties and have paved the way for using this system as a functional unit in molecular... | 25,175,333 | [
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Heparin-Binding Proteins (Chemokines and Defensins) and their complexes with glycosaminoglycans from the solution NMR perspective. | This review paper aims at discussing the major recent achievements in the field of the heparin-binding proteins (HBPs), primarily chemokines and defensins, and their complexes with glycosaminoglycans examined by solution nuclear magnetic resonance spectroscopy. As opposed to the HBPs involved in coagulation (mainly ant... | 25,175,334 | [
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HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma. | Increased expression of transporters-mediating uptake of antineoplastic drugs could render renal cell carcinoma (RCC) more sensitive to chemotherapy. Here, we studied the effect of hepatocyte nuclear factor 4α (HNF4α) on the expression of selected uptake transporters in RCC lines. Organic cation transporters (OCTs) and... | 25,175,346 | [
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Juncus maritimus root biochemical assessment for its mercury stabilization potential in Ria de Aveiro coastal lagoon (Portugal). | Major endogenous biochemical properties can make plants ideal agents for metal/metalloid-contaminated site cleanup. This study investigates the biochemistry of Juncus maritimus (Lam) roots for its high mercury (Hg) stabilization potential in the sediments of the Ria de Aveiro coastal lagoon (Portugal), which received H... | 25,175,353 | [
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Psychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations. | Psychiatric pharmaceuticals, such as anxiolytics, sedatives, hypnotics and antidepressors, are among the most prescribed active substances in the world. The occurrence of these compounds in the environment, as well as the adverse effects they can have on non-target organisms, justifies the growing concern about these e... | 25,175,354 | [
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The effect of age and clinical circumstances on the outcome of red blood cell transfusion in critically ill patients. | Whether red blood cell (RBC) transfusion is beneficial remains controversial. In both retrospective and prospective evaluations, transfusion has been associated with adverse, neutral, or protective effects. These varying results likely stem from a complex interplay between transfusion, patient characteristics, and clin... | 25,175,389 | [
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Acute extravascular hemolytic transfusion reaction due to anti-Kpa antibody missed by electronic crossmatch. | Kpa antigen is a low incidence red blood cell antigen within the Kell system. Anti-Kpa alloantibody may be associated with acute and delayed hemolytic transfusion reactions. We report a case of a clinically significant acute extravascular hemolytic transfusion reaction mediated by previously unrecognized (and undetecte... | 25,175,412 | [
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Assessing the clinical use of clear cell renal cell carcinoma molecular subtypes identified by RNA expression analysis. | To evaluate the clinical use of recently published RNA-based molecular subtyping algorithms. Patients who undergo surgery for clinically localized clear cell renal cell carcinoma can experience very different outcomes, representing a longstanding challenge for the practicing urologist. Two recent publications suggest t... | 25,175,426 | [
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Molecular and cellular biology of cerebral arteriovenous malformations: a review of current concepts and future trends in treatment. | Arteriovenous malformations (AVMs) are classically described as congenital static lesions. However, in addition to rupturing, AVMs can undergo growth, remodeling, and regression. These phenomena are directly related to cellular, molecular, and physiological processes. Understanding these relationships is essential to d... | 25,175,428 | [
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Association between posterior fossa arteriovenous malformations and prenidal aneurysm rupture: potential impact on management. | In patients with posterior fossa arteriovenous malformations (AVMs) who present with hemorrhage, feeding artery aneurysms are often the source of bleeding. The aim of this study was to evaluate the relative proportions of cases of infra- and supratentorial AVMs in which patients presented with prenidal aneurysm rupture... | 25,175,442 | [
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The natural history of AVM hemorrhage in the posterior fossa: comparison of hematoma volumes and neurological outcomes in patients with ruptured infra- and supratentorial AVMs. | Patients with posterior fossa arteriovenous malformations (AVMs) are more likely to present with hemorrhage than those with supratentorial AVMs. Observed patients subject to the AVM natural history should be informed of the individualized effects of AVM characteristics on the clinical course following a new, first-time... | 25,175,444 | [
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Getting under the skin of the primary care consultation using video stimulated recall: a systematic review. | Video stimulated recall (VSR) is a method of enhancing participants' accounts of the consultation using a video recording of the event to encourage and prompt recall in a post consultation interview. VSR is used in education and education research, and to a lesser extent in medical and nursing research. Little is known... | 25,175,450 | [
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Interactions between cholinergic and fibroblast growth factor receptors in brain trophism and plasticity. | Acetylcholine, acting on both nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs), plays a role in the regulation of synaptic plasticity, being involved in the regulation of cellular processes and cognitive functions, such as learning, memory and attention. Recently, G protein coupled receptors (GPCRs), incl... | 25,175,454 | [
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Role of dimerization in dopamine D(4) receptor biogenesis. | Dopamine receptors are G protein-coupled receptors critically involved in locomotion, reward, and cognitive processes. Export of dopamine receptors to the plasma membrane is thought to follow the default secretory pathway, whereby proteins travel from the endoplasmatic reticulum (ER), through the Golgi apparatus, to ar... | 25,175,456 | [
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Sexual Behavioral Characteristics and the Knowledge of HIV/AIDS among Men who have Sex with Men in Republic of Korea. | To investigate the sexual behavioral characteristics and HIV/AIDS knowledge among men who have sex with men (MSM), one of the HIV high risk groups. A three month survey among individuals who were able to be contacted was carried out over the entire Republic of Korea, between May and August, 2001. 348 individuals comple... | 25,175,466 | [
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Influence of smoking on blood cadmium concentration in university students. | This study was performed to examine the influence of smoking on the blood cadmium concentration in university students. The study included 300 university students. A questionnaire interview was used to collect data. The urine cotinine and blood cadmium levels were measured as biological exposure indices. The data were ... | 25,175,467 | [
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A Study of the Relationship between Parental Alcohol Problems and Alcohol Use among Adolescent Females in Republic of Korea. | The study was designed to test if alcohol use and alcohol-related problems among adolescent females are related to their parents' level of alcohol problems. In 2001, a stratified sample of 2077 adolescent females, grades 10-11, from twelve female-only high schools located in a large metropolitan city in the Republic of... | 25,175,468 | [
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Biodegradation characterization and immobilized strains' potential for quinoline degradation by Brevundimonas sp. K4 isolated from activated sludge of coking wastewater. | A novel quinoline-degrading strain, named K4, was isolated from activated sludge of a coking wastewater treatment plant and identified as Brevundimonas sp. on the basis of its 16s rDNA gene sequence analysis. Its optimum temperature and pH for quinoline degradation were 30 °C and pH 9.0, respectively, and during the bi... | 25,175,484 | [
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Facile Au catalyst loading on the inner shell of hollow SnO2 spheres using Au-decorated block copolymer sphere templates and their selective H2S sensing characteristics. | Hollow SnO2 spheres functionalized by Au catalysts were synthesized via the use of Au-decorated block copolymer (Au-BCP) sphere templates. Uniformly distributed Au nanoparticles on BCP spheres were prepared by the infiltration of Au precursors into polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) spheres. A thin SnO2 la... | 25,175,492 | [
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Mismatch between asthma symptoms and spirometry: implications for managing asthma in children. | To examine the concordance between spirometry and asthma symptoms in assessing asthma severity and beginning therapy by the general pediatrician. Between 2008 and 2012, spirometry testing was satisfactorily performed in 894 children (ages 5-19 years) whose asthma severity had been determined by their pediatrician using... | 25,175,496 | [
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A single strain of Tetratrichomonas gallinarum causes fatal typhlohepatitis in red-legged partridges (Alectoris rufa) to be distinguished from histomonosis. | Typhlohepatitis was observed in a flock of 2500 red-legged partridges in Great Britain, characterized by the sudden deaths of 15 birds within 2 days. Necropsy of five dead birds revealed severe lesions in the caeca with thickened caecal walls, a reddened lining and bloody contents. The livers contained multiple miliary... | 25,175,532 | [
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Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns. | Resting state-fMRI (rs-fMRI) in mice allows studying mechanisms underlying functional connectivity (FC) as well as alterations of FC occurring in murine models of neurological diseases. Mouse fMRI experiments are typically carried out under anesthesia to minimize animal movement and potential distress during examinatio... | 25,175,535 | [
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The auditory scene: an fMRI study on melody and accompaniment in professional pianists. | The auditory scene is a mental representation of individual sounds extracted from the summed sound waveform reaching the ears of the listeners. Musical contexts represent particularly complex cases of auditory scenes. In such a scenario, melody may be seen as the main object moving on a background represented by the ac... | 25,175,543 | [
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Recombinant Lactobacillus plantarum expressing and secreting heterologous oxalate decarboxylase prevents renal calcium oxalate stone deposition in experimental rats. | Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaOx stone diseases are limited. Oxalate degrading bacteria might have beneficial effects on urinary oxalate excre... | 25,175,550 | [
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Resection of a ventral intramedullary cervical spinal cord cavernous malformation through an anterior approach. | Ventrally-located intramedullary cervical spinal cord cavernomas are rare entities in the pediatric population. Surgical access to these lesions is challenging. The authors present the complete resection of a symptomatic ventral cervical intramedullary cavernoma through an anterior approach in a 15-year-old boy. The le... | 25,175,579 | [
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Bisphenol A exposure via thermal paper receipts. | Bisphenol A (BPA) has one of the highest production volumes of all chemicals worldwide. It has been widely studied because of its endocrine modulating activity. In addition to dietary intake, absorption of BPA via the skin from handling thermal papers is believed to be a relevant route of exposure. We studied BPA expos... | 25,175,590 | [
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Treatment of cutaneous T-cell lymphoma with oral alitretinoin. | Cutaneous T-cell lymphoma (CTCL) is a potentially life-limiting malignant disease. Treatment strategies in CTCL aim at disease control and remission with the lowest possible side-effects. Recent reports suggest that the new vitamin A derivative alitretinoin might be a well-tolerated treatment option. We analysed the fi... | 25,175,592 | [
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Transforming growth factor-β1-induced epithelial-mesenchymal transition in human esophageal squamous cell carcinoma via the PTEN/PI3K signaling pathway. | Epithelial-mesenchymal transition (EMT) is a crucial step for the invasive and metastatic properties of malignant tumor cells during tumor progression. Numerous signaling pathways are involved in the process of EMT in cancer, such as the EMT-inducing signal transforming growth factor (TGF)-β and the recently demonstrat... | 25,175,594 | [
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Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. | The urokinase-type plasminogen activator receptor (uPAR) is an important regulator of ECM proteolysis, cell-ECM interactions and cell signaling. uPAR and heat shock proteins HSP70 and MRJ (DNAJB6) have been implicated in tumor growth and metastasis. We have reported recently that MRJ (DNAJB6, a heat shock protein) can ... | 25,175,595 | [
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Abdominal Obesity in Relation to the Incidence of Type 2 Diabetes Mellitus and Impaired Fasting Glucose among some Korean Adults: A Retrospective Cohort Study. | This study was performed to determine whether an increase in abdominal obesity is an independent risk factor for impaired fasting glucose and type 2 DM. Among 24, 212 adults over 30 years who undertook comprehensive medical screening examinations from Jan to Dec 1999, in a university hospital in Seoul, a total of 11, 1... | 25,175,618 | [
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Mortality benefits of different hemodialysis access types are age dependent. | Risk of death in dialysis patients is lowest with arteriovenous fistulas (AVFs), followed by arteriovenous grafts (AVGs) and then intravenous hemodialysis catheters (HCs). Our aim was to analyze the effects of age at hemodialysis initiation on mortality across different access types. All patients ≥18 years in the Unite... | 25,175,630 | [
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Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia. | Altered levels of transcription factor specificity protein 4 (SP4) and 1 (SP1) in the cerebellum, prefrontal cortex and/or lymphocytes have been reported in severe psychiatric disorders, including early psychosis, bipolar disorder, and chronic schizophrenia subjects who have undergone long-term antipsychotic treatments... | 25,175,639 | [
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New perspective on the dual functions of indirubins in cancer therapy and neuroprotection. | Indirubin is an active ingredient mainly used to treat leukemia in China and is reported to be a leading inhibitor of cyclindependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) by competing with ATP binding sites. New findings have indicated that its comprehensive structure may contribute to its polypharmaco... | 25,175,685 | [
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Tapasin and human leukocyte antigen class I dysregulation correlates with survival in glioblastoma multiforme. | Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to cytotoxic CD8(+) T cells. Downregulation of peptide:HLA-I complexes is common in tumors and results in tumor immune escape variants. Also molecules involved in the maturation of HLA-I have been demonstrated to be dysregulated in malignant n... | 25,175,688 | [
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Prognostic value of estimating functional capacity with the use of the duke activity status index in stable patients with chronic heart failure. | Over the years, several methods have been developed to reliably quantify functional capacity in patients with heart failure. Few studies have investigated the prognostic value of these assessment tools beyond cardiorenal prognostic biomarkers in stable patients with chronic heart failure. We administered the Duke Activ... | 25,175,697 | [
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Evaluation of detachment methods for the enumeration of Bacteroides fragilis in sediments via propidium monoazide quantitative PCR, in comparison with Enterococcus faecalis and Escherichia coli. | The aim was to develop an optimized detachment method for separating Bacteroidales from sediments to allow enumeration via PMA-qPCR. The effectiveness of four different detachment treatments in removing Bacteroides fragilis was compared as a function of time as well as in relation to Enterococcus faecalis and Escherich... | 25,175,698 | [
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Bioavailability of ginsenosides from white and red ginsengs in the simulated digestion model. | This study aims to investigate the bioavailability of ginsenosides during simulated digestion of white (WG) and red (RG) ginseng powders. Stability, bioaccessibility, and permeability of ginsenosides present in WG and RG were studied in a Caco-2 cell culture model coupled with oral, gastric, and small intestinal simula... | 25,175,701 | [
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Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: potential mechanism. | Liver irradiation leads to a decreased uptake of a hepatobiliary directed MRI contrast agent (Gd-EOB-DTPA) as shown in studies performed 1-6 months after proton therapy, stereotactic ablative body radiation therapy and brachytherapy. Therefore, Gd-EOB-DTPA enhanced MRI could potentially be used for in vivo verification... | 25,175,713 | [
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Longitudinal prevalence, faecal shedding and molecular characterisation of Campylobacter spp. and Salmonella enterica in sheep. | Faecal excretion of Campylobacter spp. and Salmonella enterica in sheep in Australia was determined using a quantitative multiplex PCR (qPCR) targeting the Campylobacter spp. purine biosynthesis gene (PurA) and the S. enterica outer membrane protein (ompF). The mutiplex qPCR was specific and Campylobacter spp. and S. e... | 25,175,721 | [
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Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes. | Free fatty acids (FFAs) are metabolic intermediates that may be obtained through the diet or synthesized endogenously. In addition to serving as an important source of energy, they produce a variety of both beneficial and detrimental effects. They play essential roles as structural components of all cell membranes and ... | 25,175,736 | [
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Clostridium difficile increases the risk for venous thromboembolism. | Inflammatory bowel disease is associated with a higher risk for venous thromboembolism (VTE). Whether Clostridium difficile infection similarly increases this risk is unknown. This was a retrospective analysis of patients admitted to the surgical intensive care unit (ICU) at the Cedars-Sinai Medical Center from Februar... | 25,175,741 | [
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c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. | Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading to a myofibroblast phenotype is the principal feature that orchestrates this fibrotic process. The aim of this study was to assess the effects induced by TGF-β... | 25,175,743 | [
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Acute effect of sorghum flour-containing pasta on plasma total polyphenols, antioxidant capacity and oxidative stress markers in healthy subjects: A randomised controlled trial. | It has been previously reported that pasta containing wholegrain sorghum flour exhibits high content of polyphenols and antioxidant capacity and hence might enhance antioxidant status and reduce markers of oxidative stress in vivo; however no clinical studies have yet been reported. Therefore, the present study assesse... | 25,175,757 | [
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Demographic factors associated with overuse of Pap testing. | Since 2003, U.S. Preventive Services Task Force guidelines recommend against Pap testing for women without a cervix following a hysterectomy and those aged >65 years. Few population-based studies have investigated factors associated with overuse of Pap testing in the U.S. To evaluate patient characteristics associat... | 25,175,763 | [
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Feasibility and preliminary efficacy of the effects of flavanoid-rich purple grape juice on the vascular health of childhood cancer survivors: a randomized, controlled crossover trial. | Childhood cancer survivors have an increased risk of developing cardiovascular disease following treatment, yet few interventions have been evaluated to reduce this risk. Purple grape juice (pGJ), a rich source of flavonoids with antioxidant properties, has been shown in adults to reduce oxidative stress and improve en... | 25,175,762 | [
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Reducing childhood obesity through U.S. federal policy: a microsimulation analysis. | Childhood obesity prevalence remains high in the U.S., especially among racial/ethnic minorities and low-income populations. Federal policy is important in improving public health given its broad reach. Information is needed about federal policies that could reduce childhood obesity rates and by how much. To estimate t... | 25,175,764 | [
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The complete plasmid sequences of Salmonella enterica serovar Typhimurium U288. | Salmonella enterica Serovar Typhimurium U288 is an emerging pathogen of pigs. The strain contains three plasmids of diverse origin that encode traits that are of concern for food security and safety, these include antibiotic resistant determinants, an array of functions that can modify cell physiology and permit geneti... | 25,175,817 | [
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ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. | Amyotrophic Lateral Sclerosis (ALS) is a slowly progressing neurodegenerative disease that affects motor neurons of the nervous system. Despite the identification of many potential therapeutics targeting pathogenic mechanisms in in vitro models, there has been limited progress in translating them into a successful phar... | 25,175,835 | [
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Effects of platelet-rich plasma and cell coculture on angiogenesis in human dental pulp stem cells and endothelial progenitor cells. | Platelet-rich plasma (PRP) has been described as platelet concentrate. Growth factors released by activated platelets can improve wound vasculogenesis and enhance wound healing. In this study, we used PRP instead of serum to culture human dental pulp stem cells (hDPSCs) and endothelial progenitor cells (EPCs) and inves... | 25,175,848 | [
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Simultaneous Vitality and DNA-fragmentation measurement in spermatozoa of smokers and non-smokers. | Background: Because cigarette smoke is a powerful ROS producer, we hypothesized that the spermatozoa of smokers would be more at risk of having increased DNA fragmentation than spermatozoa of non-smoking men. Methods: A Cross-Sectional Study was performed on consenting smokers and non-smokers, consulting in an infertil... | 25,175,858 | [
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Neuroimmune mechanisms of alcohol and drug addiction. | Alcohol and other drugs of abuse have significant impacts on the neuroimmune system. Studies have demonstrated that drugs of abuse interact with the neuroimmune system and alter neuroimmune gene expression and signaling, which in turn contribute to various aspects of addiction. As the key component of the CNS immune sy... | 25,175,859 | [
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Optical waveguide sensor based on silica nanotube arrays for label-free biosensing. | Label-free biosensing based on optical waveguide spectroscopy of silica nanotube (SNT) arrays is realized with high sensitivity. The SNT arrays fabricated using a porous anodic alumina (PAA) template assisted by surface sol-gel (SSG) method showed a high value of 552 reciprocal refractive index unit as the sensing figu... | 25,175,877 | [
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The impact of shyness on problematic internet use: the role of loneliness. | In recent years, research indicated that the problematic effects of Internet use must be examined together with individual differences present in its users with which such effects are contingent. This study examined loneliness in adolescents as a mediator of the relationship between shyness and their generalized proble... | 25,175,891 | [
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Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation. | The scale of depression in patients with chronic liver disease (CLD) and those who have received orthotopic liver transplantation (OLT) is poorly characterised. Clinicians are uncertain of how best to manage depression within these patients. To review the literature evaluating both the prevalence and impact of depressi... | 25,175,904 | [
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Efficiency of hysteroscopic visualization of bubaline uterus. | Abattoir derived buffalo genitalia (n=98) were evaluated for uterine pathology employing palpable, ultrasonographic and hysteroscopic visualization. A high proportion (45.92%) of genitalia evidenced uterine pathology including endometritis (14.29%), pyometra (7.14%), hemorrhages in the endometrium (14.29%) and mucometr... | 25,175,905 | [
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Medication errors reported to U.S. Poison Control Centers, 2000-2012. | Previous studies of medication errors have largely focused on healthcare facilities and have not reported generalizable national trends among out-of-hospital medication errors. We sought to understand U.S. trends in medication errors, including the age-related risks, the involved medications, and the medical outcomes. ... | 25,175,900 | [
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Species-specific regulation of fibrinogen synthesis with implications for porcine hepatocyte xenotransplantation. | Patients with liver failure could potentially be bridged with porcine xenogeneic liver cell transplantation. We examined species-specific differences between primary human and porcine hepatocytes in the regulation of coagulation protein expression and function. Isolated primary human and porcine hepatocytes were stimul... | 25,175,927 | [
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Stereotactic body radiotherapy for recurrent oropharyngeal cancer - influence of HPV status and smoking history. | HPV status and smoking history stratifies patients into 3 distinct risk groups for survival following definitive chemoradiotherapy. Local-regional recurrences are common patterns of failure across all 3 risk-groups. SBRT±cetuximab has emerged as a promising salvage strategy for unresectable locally-recurrent, previousl... | 25,175,942 | [
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Early experience treating tricuspid valve endocarditis with a novel extracellular matrix cylinder reconstruction. | The short-term outcomes were evaluated in patients treated for tricuspid valve endocarditis using a novel extracellular matrix (ECM) cylinder reconstruction technique. Patients with clinically significant tricuspid regurgitation whose valves were not repairable by conventional techniques underwent valve replacement wit... | 25,175,957 | [
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Involvement of adenosine A2A receptors in depression and anxiety. | When administered to normal healthy patients, a nonselective adenosine A1/A2A antagonist, caffeine, tended to improve anxiety and depression at low doses and to exacerbate anxiety at high doses. Caffeine also appears to enhance anxiety-related symptoms in patients with panic disorder, and A2A receptor-deficient mice ha... | 25,175,973 | [
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0.113473,
-0.08042289,
0.0274421,
-0.3471957,
0.1909657,
-0.2168665,
-0.03136574,
-0.0766344,
0.1700756,
-0.284965,
... |
The adenosine neuromodulation system in schizophrenia. | The management of schizophrenia endophenotypes, namely positive, negative, and cognitive symptoms is still an open goal, justifying the search of novel therapeutic avenues. We now review the evidence supporting the interest in targeting the adenosine modulation system to counteract the core features of schizophrenia. T... | 25,175,974 | [
-0.05466713,
0.03212682,
0.2236043,
-0.2559708,
0.2486668,
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0.3730075,
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0.0006186137,
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0.2333275,
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-0.5645048,
-0.2050767,
-0.2202812,
-0.3358475,
0.1492854,
0.02576828,
-0.3245... |
A longitudinal investigation of the friendship model of relational interdependent self-construal. | A four-wave longitudinal study examined how relational-interdependent self-construal (RISC) or the tendency to think of one's self in terms of close relationships, was related to cognitions and behaviors within friendships. In same-sex friendships, in both concurrent and prospective analyses, own RISC was associated wi... | 25,175,990 | [
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0.09682135,
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0.05191163,
0.1405147,
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0.06237334,
0.11368... |
Anatomic structures at risk: curved hindfoot arthrodesis nail--a cadaveric approach. | Retrograde intramedullary nailing of the hindfoot and ankle is an established procedure for salvage of severe foot and ankle deformity, arthritis, tumor, and instability. In the present study, retrograde hindfoot (tibiotalocalcaneal) arthrodesis nailing was performed using a standardized technique on 7 cadaver specimen... | 25,176,005 | [
-0.2447848,
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0.3881573,
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-0.02813549,
0.03390255,
0.302665,
0.10935... |
Sparing surgery with the use of TiNi-based endografts in larynx cancer patients. | Purpose of this study was to improve a technique of sparing surgery in patients with laryngeal cancer by using TiNi-based endografts and to achieve well functional and oncological results after laryngectomy. Totally 120 patients with laryngeal cancer were observed (T2-3 N0-1 M0 ). We have developed a method of laryngea... | 25,176,032 | [
-0.06224512,
0.2009716,
-0.3408053,
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0.02344258,
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0.1824776,
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-0.4354027,
0.06410536,
0.5187013,
0.4165506,
0.01044103,
... |
Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. | Peroxisome biogenesis disorders (PBD) are autosomal recessive disorders in humans characterized by skeletal, eye and brain abnormalities. Despite the fact that neurological deficits, including peripheral nervous system (PNS) defects, can be observed at birth in some PBD patients including those with PEX10 mutations, th... | 25,176,044 | [
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0.04982082,
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-0.1942522,
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0.2810285,
0.19424... |
Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats. | This study was undertaken to study the effects of melatonin on metabolic and reproductive aspects of polycystic ovary syndrome (PCOS) in rats. PCOS was induced by daily subcutaneous administration of testosterone (20 mg/kg) to 21-day-old female rats for 35 days. Rats were given metformin (500 mg/kg), melatonin (1 mg/kg... | 25,176,048 | [
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0.3421569,
0.07680488,
-0.1805381,
-0.06775768,
-0.098320... |
Clever Hans and his effects: Karl Krall and the origins of experimental parapsychology in Germany. | Shortly before the outbreak of World War I, the so-called Elberfeld horses, the counting and speaking animals, were among the most debated subjects of the newborn comparative psychology. Yet, they have left little trace in the historiography of this discipline, mostly as an appendix of the more famous Clever Hans. Thei... | 25,176,052 | [
0.09576419,
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0.1517537,
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0.1791806,
0.2981032,
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0.0487855,
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0.1765404,
0.1571367,
-0.03986831,
... |
Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response. | Chronic implantation of microelectrodes into the cortex has been shown to lead to inflammatory gliosis and neuronal loss in the microenvironment immediately surrounding the probe, a hypothesized cause of neural recording failure. Caspase-1 (aka Interleukin 1β converting enzyme) is known to play a key role in both infla... | 25,176,060 | [
-0.1367941,
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0.05775508,
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0.1520273,
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0.1559009,
0.1288219,
0.1710069,
0.02988013,... |
The effect of keratinocytes on the biomechanical characteristics and pore microstructure of tissue engineered skin using deep dermal fibroblasts. | Fibrosis affects most organs, it results in replacement of normal parenchymal tissue with collagen-rich extracellular matrix, which compromises tissue architecture and ultimately causes loss of function of the affected organ. Biochemical pathways that contribute to fibrosis have been extensively studied, but the role o... | 25,176,070 | [
0.2457755,
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0.1097977,
0.1001978,
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0.04354112,
0.364922,
0.2890392,
0.08349288,
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-0.5563343,
-0.2519831,
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-0.196226,
-0.07975117,
-0.2521867,
-0.01295135,
0.01790816,
0.2564128,
-0.3221155,
... |
Dynamic changes of tear fluid matrix metralloproteinase-9 within 1 year after laser in situ keratomileusis. | To investigate the dynamic changes of matrix metalloproteinase-9 (MMP-9) level in tear fluid within 12 months after laser in situ keratomileusis (LASIK). Twenty-two myopic patients undergoing uneventful LASIK were enrolled in this study. Tear fluid samples were collected from the patients for measurements of MMP-9 leve... | 25,176,071 | [
-0.003298833,
-0.3300028,
-0.3702264,
-0.3275552,
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0.4972709,
0.1512852,
0.513174,
0.112869,
-0.05973601,
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0.09888664,
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-0.1418137,
0.1039852,
-0.1729238,
-0.05629784,
0.2560703,
0.002721454,
-0.117698... |
[Alternation of retinal complement system in a mouse model of lipopolysaccharide- induced uveitis]. | To investigate the activation of the complement system in the retina in a mouse model of endotoxin-induced uveitis (EIU). Balb/c mice were randomly divided into control group and lipopolysaccharide (LPS)-induced EIU group. Twenty-four hours after modeling, the expressions of the major complement components of the class... | 25,176,078 | [
0.02603511,
0.1241937,
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0.0249284,
0.414226,
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0.09094034,
0.3284611,
0.2242891,
0.08785381,
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0.01226763,
0.01391847,
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0.07163186,
-0.6056814,
0.05221391,
-0.009244815,
-0.2453795,
-0.03865427,
-0.1428214,
0.0536270... |
[Long-term outcomes of transcatheter arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma]. | To analyze the long-term therapeutic effects of transcatheter arterial chemoembolization (TACE) before liver transplantation. Forty-six patients with hepatocellular carcinoma (HCC) undergoing liver transplantation in our department between November, 2009 and November, 2011 were analyzed. Of these patients, 24 received ... | 25,176,083 | [
0.06368195,
0.0700386,
-0.6395468,
0.1785759,
0.03002588,
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0.07993775,
0.318777,
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0.2453029,
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0.4327011,
0.1205123,
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0.3353398,
0.1156489,
0.4753187,
0.03866378,
0.2499063,
-0.0743919,
0.12... |
[Effects of glucose variation on hexose monophosphate shunt and leucocyte respiratory burst in patients with type 2 diabetes]. | To investigate the effect of blood glucose instability on respiratory burst of leukocytes in patients with type 2 diabetes (T2DM). Forty-five patients with T2DM were divided into 3 groups after continuous glucose monitoring for 72 h with glucose wavy coefficient <1.5 (n=11), between 1.5 and 3.0 (n=19), and >3.0 (... | 25,176,092 | [
0.03175914,
-0.06806866,
-0.2876101,
0.1289294,
0.3569305,
-0.5869389,
0.007064609,
-0.02752465,
-0.02680134,
-0.232363,
0.3021973,
0.08781807,
-0.2728914,
0.007748067,
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-0.2197954,
-0.2545604,
0.2677374,
-0.08876524,
0.2058796,
-0.008660205,
-0.03659293,
0.178... |
[Efficacy and safety of Stronger Neo-Minophagen C for treatment of chronic hepatitis B: a meta-analysis of randomized controlled trials]. | To compare the efficacy and safety of Stronger Neo-Minophagen C (SNMC) in the treatment of chronic hepatitis B. We searched MEDLINE, EMBASE, CBM, and CNKI up to December, 2012 to identify randomized controlled trials (RCTs) comparing Stronger Neo-Minophagen C plus other therapy versus others therapy for chronic hepatit... | 25,176,104 | [
-0.08909101,
0.1797008,
-0.2150584,
0.04087032,
0.1225632,
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0.1932164,
0.1159326,
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0.02595911,
0.3719376,
0.1565189,
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0.1907846,
-0.02504468,
0.5475646,
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-0.1428753,
-0.02620013,... |
Performance of serum prostate-specific antigen isoform [-2]proPSA (p2PSA) and the prostate health index (PHI) in a Chinese hospital-based biopsy population. | The use of serum [-2]proPSA (p2PSA) and its derivative, the prostate health index (PHI), in detecting prostate cancer (PCa) have been consistently shown to have better performance than total prostate-specific antigen (tPSA) in discriminating biopsy outcomes in western countries. However, little is known about their per... | 25,176,131 | [
0.08624376,
0.1205141,
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0.008886136,
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0.5022724,
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0.04825889,
0.06274778,
0.2347722,
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0.2531547,
0.1395221,
-0.3257724,
... |
Perioperative radiotherapy is associated with improved survival among patients with synovial sarcoma: A SEER analysis. | We examined the outcomes of synovial sarcoma (SS) patients in a national database. We identified 1,189 patients from the Surveillance, Epidemiology, and End Results (SEER) database with data on site and extent of surgery. We excluded patients diagnosed before 1990, <18 years, or lacking pathologic confirmation. Usin... | 25,176,165 | [
-0.0365524,
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-0.421709,
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0.1594685,
0.1489017,
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0.1278511,
0.1032182,
0.005922706,
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0.3898419,
0.1948226,
0.2392971,
0.1232509,
0.03373169,
0.2954441,
-0.2337266,
0... |
Conversion of kraft lignin under hydrothermal conditions. | The aim of this study is to explore hydrothermal conversion of kraft lignin for value-added products. With ranging between 5.4% and 10.6%, total oil yield decreased with the increase of temperature (130, 180, and 230°C), the longer reaction time (15-60min) led to increased total oil yield. Main compound of oils charact... | 25,176,169 | [
0.2660329,
0.05076899,
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-0.1421851,
0.2130419,
0.09076128,
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0.1584161,
0.07306135,
0.05912899,
-0.09341467,
0.1694326,
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0.1046309,
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0.440006,
0.2522091,
0.1354054,
0.2863318,
0.1066212,
-0.2512758,
0.00... |
Assessment of radiation doses to the para-aortic, pelvic, and inguinal lymph nodes delivered by image-guided adaptive brachytherapy in locally advanced cervical cancer. | This study evaluated the dose delivered to lymph nodes (LNs) by brachytherapy (BT) and the effect of BT image-guided optimization on the LN dose. Twenty-five patients with locally advanced cervical cancer were retrospectively analyzed, 16 patients of them had LN involvement. The patients received whole pelvis intensity... | 25,176,182 | [
0.03960504,
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0.4655025,
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0.362668,
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0.1641601,
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0.131335,
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-0.05180318,
-0.398323,
0.07506605,
0.2168401,
0.1861279,
0.08989151,
0.... |
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