title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Incidence of remission in adults with type 2 diabetes: the diabetes & aging study. | To estimate the incidence of remission in adults with type 2 diabetes not treated with bariatric surgery and to identify variables associated with remission. We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healthcare delivery syste... | 25,231,895 | [
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Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes. | Sulfonylureas (SUs) are effective at controlling glycemia in permanent neonatal diabetes mellitus (PNDM) caused by KCNJ11 (Kir6.2) mutations. We report the case of a woman with PNDM who continued high doses of glibenclamide (85 mg/day) during her pregnancy. The baby was born preterm, and presented with macrosomia and s... | 25,231,897 | [
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Each degree of glucose intolerance in pregnancy predicts distinct trajectories of β-cell function, insulin sensitivity, and glycemia in the first 3 years postpartum. | Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes mellitus (T2DM) that is proportional to the severity of antepartum dysglycemia (i.e., highest in women with gestational diabetes mellitus [GDM], followed by those with milder dysglycemia). However, the pathophysiologic changes driving... | 25,231,898 | [
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Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. | Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in four types of Alzheimer's disease (AD) mouse models and human AD postmortem brains. We identified commonly changed phosphoproteins in multiple models and also determined phosphoproteins related to initiation of amyloid beta (Aβ) depo... | 25,231,903 | [
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Childhood consequences of maternal obesity and excessive weight gain during pregnancy. | Obesity is a major public health concern. In western countries, the prevalence of obesity in pregnant women has strongly increased, with reported prevalence rates reaching 30%. Also, up to 40% of women gain an excessive amount of weight during pregnancy. Recent observational studies and meta-analyses strongly suggest l... | 25,231,923 | [
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Bimodal oscillations of cyclic nucleotide concentrations in the circadian system of the Madeira cockroach Rhyparobia maderae. | Pigment-dispersing factor (PDF) is the most important coupling factor of the circadian system in insects, comparable to its functional ortholog vasoactive intestinal polypeptide of the mammalian circadian clock. In Drosophila melanogaster, PDF signals via activation of adenylyl cyclases, controlling circadian locomotor... | 25,231,947 | [
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Comparative analysis of MAMP-induced calcium influx in Arabidopsis seedlings and protoplasts. | Rapid transient elevation of cytoplasmic calcium (Ca(2+)) levels in plant cells is an early signaling event triggered by many environmental cues including abiotic and biotic stresses. Cellular Ca(2+) levels and their alterations can be monitored by genetically encoded reporter systems such as the bioluminescent protein... | 25,231,962 | [
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Whole-plant growth and N utilization in transgenic rice plants with increased or decreased Rubisco content under different CO2 partial pressures. | Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) strongly limits photosynthesis at lower CO2 concentration [CO2] whereas [corrected] Rubisco limitation is cancelled by elevated [CO2]. Therefore, increase or reduction in Rubisco content by transformation with a sense or an antisense RBCS construct are expected ... | 25,231,963 | [
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Ultraviolet-B radiation and water deficit interact to alter flavonol and anthocyanin profiles in grapevine berries through transcriptomic regulation. | UV-B radiation and water deficit may trigger flavonol and anthocyanin biosynthesis in plant tissues. In addition, previous research has showed strong qualitative effects on grape berry skin flavonol and anthocyanin profiles in response to UV-B and water deficit. The aim of this study is to identify the mechanisms leadi... | 25,231,967 | [
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Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion. | Francisella tularensis is the etiological agent of tularemia, or rabbit fever. Although F. tularensis is a recognized biothreat agent with broad and expanding geographical range, its mechanism of infection and environmental persistence remain poorly understood. Previously, we identified seven F. tularensis proteins tha... | 25,231,992 | [
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NRF2/long noncoding RNA ROR signaling regulates mammary stem cell expansion and protects against estrogen genotoxicity. | Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression in embryonic stem cell (ESC) self-renewal and differentiation. In ESCs, lncRNAs are regulated at the genetic level via transcription factor binding to lncRNA gene promoters. Here we demonstrate that the key cytoprotective transcription fact... | 25,231,996 | [
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Six versus fewer planned cycles of first-line platinum-based chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data. | Platinum-based chemotherapy is the standard first-line treatment for patients with advanced non-small-cell lung cancer. However, the optimum number of treatment cycles remains controversial. Therefore, we did a systematic review and meta-analysis of individual patient data to compare the efficacy of six versus fewer pl... | 25,232,001 | [
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TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. | Rab11a is a key modulator of vesicular trafficking processes, but there is limited information about the guanine nucleotide-exchange factors and GTPase-activating proteins (GAPs) that regulate its GTP-GDP cycle. We observed that in the presence of Mg(2+) (2.5 mM), TBC1D9B interacted via its Tre2-Bub2-Cdc16 (TBC) domain... | 25,232,007 | [
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A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. | Despite the importance of ADAM17-dependent cleavage in normal biology and disease, the physiological cues that trigger its activity, the effector pathways that promote its function, and the mechanisms that control its activity, particularly the role of phosphorylation, remain unresolved. Using native bladder epithelium... | 25,232,008 | [
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Polycystic kidneys and GM2 gangliosidosis-like disease in neonatal springboks (Antidorcas marsupialis). | Clinical, gross, histopathologic, electron microscopic findings and enzymatic analysis of 4 captive, juvenile springboks (Antidorcas marsupialis) showing both polycystic kidneys and a storage disease are described. Springbok offspring (4 of 34; 12%) were affected by either one or both disorders in a German zoo within a... | 25,232,033 | [
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Micronuclei and nuclear abnormalities in buccal mucosa cells in patients with anorexia and bulimia nervosa. | The aim of this study is to assess the frequency of micronucleated cell (MNC) and nuclear abnormalities (NA) in the buccal mucosa cells of females with anorexia nervosa (AN) or bulimia nervosa (BN), compared with healthy women. Individuals with AN and BN have inadequate feeding and compensatory behaviour to avoid weigh... | 25,232,046 | [
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Magnetic field-driven induction of ZENK in the trigeminal system of pigeons (Columba livia). | Magnetoreception remains one of the few unsolved mysteries in sensory biology. The upper beak, which is innervated by the ophthalmic branch of the trigeminal nerve (V1), has been suggested to contain magnetic sensors based on ferromagnetic structures. Recently, its existence in pigeons has been seriously challenged by ... | 25,232,052 | [
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Recurrence of hip instability after reconstructive surgery in patients with cerebral palsy. | Hip instability can cause major problems in children with cerebral palsy, although good outcomes of hip reconstructive surgery for hip instability have been reported. In the present study, we investigated the recurrence of hip instability after reconstructive surgery and the factors influencing this recurrence in patie... | 25,232,076 | [
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Emerging multidrug resistance of methicillin-resistant Staphylococcus aureus in hand infections. | Methicillin-resistant Staphylococcus aureus has been the most commonly identified pathogen in hand infections at urban centers, but the evolving antibiotic sensitivity profiles of methicillin-resistant Staphylococcus aureus are not known. The purposes of this study are to determine if multidrug resistance in methicilli... | 25,232,077 | [
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Factors predicting complication and reoperation rates following surgical fixation of proximal humeral fractures. | The purpose of this study was to report complication and reoperation rates following non-arthroplasty fixation of shoulder fractures determined on the basis of observational, population-based data from all inpatient admissions in California over an eleven-year period. Records from all inpatient hospital discharges and ... | 25,232,078 | [
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Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology. | Synapses are surrounded by a layer of extracellular matrix (ECM), which is instrumental for their development and maintenance. ECM composition is dynamically controlled by proteases, but how the precise composition of the ECM affects synaptic morphology is largely unknown. Through an unbiased forward genetic screen, we... | 25,232,106 | [
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The recurrent case for the Renshaw cell. | Although Renshaw cells (RCs) were discovered over half a century ago, their precise role in recurrent inhibition and ability to modulate motoneuron excitability have yet to be established. Indirect measurements of recurrent inhibition have suggested only a weak modulatory effect but are limited by the lack of observed ... | 25,232,126 | [
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Invalid controls undermine conclusions of FDA studies. | This issue of Toxicological Sciences features several exciting changes: a redesigned cover, revised category subheadings, and this "Look Inside ToxSci" feature. Together with my esteemed colleagues in the field of green chemistry, we have outlined some exciting opportunities for the field of toxicology in the editorial... | 25,232,149 | [
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Multilocus sequence typing (MLST) and whole-genome MLST of Campylobacter jejuni isolates from human infections in three districts during a seasonal peak in Finland. | A total of 95 human Campylobacter jejuni isolates acquired from domestic infections and collected from three districts in Finland during the seasonal peak (June to September) in 2012 were analyzed by PCR-based multilocus sequence typing (MLST) and by whole-genome sequencing (WGS). Four predominant sequence types (STs) ... | 25,232,158 | [
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The fringe benefits of cloning cancer. | A new approach to monitoring tumor clone dynamics (Carreira et al., this issue) uses sequential biopsies and circulating DNA to help optimize treatment in metastatic prostate cancer. | 25,232,174 | [
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EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice. | Enterococci bacteria are a frequent cause of catheter-associated urinary tract infections, the most common type of hospital-acquired infection. Treatment has become increasingly challenging because of the emergence of multiantibiotic-resistant enterococcal strains and their ability to form biofilms on catheters. We ide... | 25,232,179 | [
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Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response. | Anti-CTLA-4 treatment improves the survival of patients with advanced-stage melanoma. However, although the anti-CTLA-4 antibody ipilimumab is now an approved treatment for patients with metastatic disease, it remains unknown by which mechanism it boosts tumor-specific T cell activity. In particular, it is unclear whet... | 25,232,180 | [
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Comprehensive treatment of a functional pancreatic neuroendocrine tumor with multifocal liver metastases. | A 64-year-old man was admitted to the Sun Yat-Sen University Cancer Center with chief complaints of recurrent abdominal pain and diarrhea for about 3 years and with a history of surgical repair for intestinal perforation owing to stress ulcer. Positron emission tomography (PET)/computed tomography (CT) demonstrated a p... | 25,232,226 | [
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Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma. | To investigate cell type specific distribution of β-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters. β-actin is a housekeeping gene, frequently used as loading control, but, differentially expresses in cancer. In gastric cancer, an overall increased expression of β-act... | 25,232,253 | [
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Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases. | To investigate whether Helicobacter pylori (H. pylori) infection contributes to idiopathic thrombocytopenic purpura (ITP) or iron-deficiency anemia (IDA) onset in gerbils. A total of 135 Mongolian gerbils were randomly divided into two groups: an H. pylori infection group and a control group. Both groups were fed the s... | 25,232,266 | [
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Osteonecrosis of the femoral head with collapsed medial lesion. | A 60-year-old female experienced the gradual onset of left hip pain without any triggering event. Radiographs showed vertical sclerosis in the center of the femoral head and the lesion inside the boundary demonstrated diffuse bony sclerosis. No collapse was observed at the weight-bearing portion on radiograph. However,... | 25,232,284 | [
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Stereochemistry and Mechanism of Enzymatic and Non-Enzymatic Hydrolysis of Benzylic <i>sec</i>-Sulfate Esters. | The substrate scope of inverting alkylsulfatase Pisa1 was extended towards benzylic <isec</i-sulfate esters by suppression of competing non-enzymatic autohydrolysis by addition of dimethyl sulfoxide as co-solvent. Detailed investigation of the mechanism of autohydrolysis in <sup18</supO-labeled buffer by using an enant... | 25,232,289 | [
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MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura. | Due to an increased frequency of vasculitis in FMF patients, many investigators have studied MEFV mutations in patients with HSP. The aim of the study is to investigate the frequency and clinical significance of MEFV mutations in Egyptian children with Henoch-Schonlein purpura (HSP). Investigating MEFV mutations in con... | 25,232,290 | [
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A case of metastatic bladder cancer in both lungs treated with korean medicine therapy alone. | This case report is aimed to investigate the effects of Korean medicine therapy (KMT) including oral herbal medicine and herb nebulizer therapy in treating metastatic bladder cancer in the lungs. A 74-year-old man was diagnosed with metastatic bladder cancer in both lungs in August 2013. He refused any chemotherapy and... | 25,232,323 | [
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Cynophobic fear adaptively extends peri-personal space. | Peri-personal space (PPS) is defined as the space immediately surrounding our bodies, which is critical in the adaptation of our social behavior. As a space of interaction with the external world, PPS is involved in the control of motor action as well as in the protection of the body. The boundaries of this PPS are kno... | 25,232,342 | [
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Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms. | The incidence of type 2 diabetes significantly increases with age. The relevance of this association is dramatically magnified by the concomitant global aging of the population, but the underlying mechanisms remain to be fully elucidated. Here, some recent advances in this field are reviewed at the level of both the pa... | 25,232,350 | [
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TCPs, WUSs, and WINDs: families of transcription factors that regulate shoot meristem formation, stem cell maintenance, and somatic cell differentiation. | In contrast to somatic mammalian cells, which cannot alter their fate, plant cells can dedifferentiate to form totipotent callus cells and regenerate a whole plant, following treatment with specific phytohormones. However, the regulatory mechanisms and key factors that control differentiation-dedifferentiation and cell... | 25,232,356 | [
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The role of photosynthesis and amino acid metabolism in the energy status during seed development. | Seeds are the major organs responsible for the evolutionary upkeep of angiosperm plants. Seeds accumulate significant amounts of storage compounds used as nutrients and energy reserves during the initial stages of seed germination. The accumulation of storage compounds requires significant amounts of energy, the genera... | 25,232,362 | [
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The Perceived Needs and Availability of Eye Care Services for Older Adults in Long-term Care Facilities. | The objective was to evaluate the eye care services offered to older residents living in long-term care facilities (LTCFs). A questionnaire targeting residents aged ≥65 years was sent to all LTCFs in Quebec. Questions related to the institution's characteristics, demographic data related to residents, oculovisual healt... | 25,232,370 | [
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Detection of common carotid artery calcifications on panoramic radiographs: prevalence and reliability. | The aim of this study was to determine the prevalence of common carotid artery calcifications (CCAC) detected by panoramic radiographs (PR) in the population and main risk factors with review of the literature. Furthermore, the reliability of PR was verified to detect these calcifications. CCAC detected on PR was power... | 25,232,373 | [
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Effect of trichostatin a on SGC-7901 gastric cancer cells. | To explore Trichostatin A (TSA) effect on SGC-7901 gastric cancer cells. MTT, fluorescence microscopy, and flow cytometry were used to assess TSA effect on cell growth and apoptosis in SGC-7901. Immunocytochemistry was used to evaluate the expression of acetylated histone H4 in SGC-7901 cells.Gene expression profile wa... | 25,232,376 | [
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Effects and mechanisms of indol-2,3-dione on atherosclerosis. | Indol-2,3-dione (ISA), a natural substance with clear structure, has been shown to process anti-inflammatory, antioxidant and anti-atherosclerosis activity in vivo. The purpose of this study was to investigate the effect and mechanism of ISA on AS by primary rat cardiac microvascular endothelial cells (rCMEC). rCMEC ce... | 25,232,391 | [
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Assessment of ventricular repolarization inhomogeneity in patients with mitral valve prolapse: value of T wave peak to end interval. | Mitral valve prolapse (MVP) has been long known for causing susceptibility for ventricular arrhythmogenesis, and this risk was evaluated by various methods, mostly by using QT interval related measurements on surface electrocardiogram. T wave peak to end (Tp-e) interval is a relatively new marker for ventricular arrhyt... | 25,232,403 | [
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Polymeric immunoglobulin receptor expression is predictive of poor prognosis in glioma patients. | Although there have been recent advances in surgery, radiotherapy, and chemotherapy, the survival of patient with glioma remains poor. Increased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various cancer forms. However, the clinical relevance of pIgR in glioma remains unc... | 25,232,405 | [
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Effects of hypertonic saline - hydroxyethyl starch and mannitol on serum osmolality, dural tension and hemodynamics in patients undergoing elective neurosurgical procedures. | To investigate effect of equal volumes (250 ml) of 7.2% hypertonic saline - 6% hydroxyethyl starch (HS-HES) and 20% mannitol (M) on dural tension, serum osmolality and hemodynamics in patients during elective neurosurgical procedures. Forty ASA I-II patients scheduled for elective neurosurgical supratentorial procedure... | 25,232,419 | [
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Effect of hepatitis C virus infection on the right ventricular functions, pulmonary arterypressure and pulmonary vascular resistance. | Hepatitis secondary to infection with the hepatitis C virus (HCV) is one of themost common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HCV infection have been recognized. In this study we aimed to examine right ventricular systolic functions and pulmonary artery pressure in HCV patients... | 25,232,427 | [
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Role of endoscopic ultrasound in the diagnosis of pancreatic cancer. | Endoscopic ultrasonography (EUS) with or without fine needle aspiration has become the main technique for evaluating pancreatobiliary disorders and has proved to have a higher diagnostic yield than positron emission tomography, computed tomography (CT) and transabdominal ultrasound for recognising early pancreatic tumo... | 25,232,461 | [
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Activation of the Wnt pathway through Wnt2 promotes metastasis in pancreatic cancer. | Wnt signaling pathway plays an important role in physiological and pathological process, including in the occurrence and development of tumor. The purpose of this study is to determine whether Wnt2 and sFRP4, key molecules of signaling pathway, are of prognostic value for survival in patients with pancreatic cancer. We... | 25,232,495 | [
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Anticancer properties of novel aminoacetonitrile derivative monepantel (ADD 1566) in pre-clinical models of human ovarian cancer. | Monepantel (MPL) is a new anthelmintic agent approved for the treatment of nematode infections in farm animals. As a nematicide, it acts through a nematode-specific nicotinic receptor subtype which explains its exceptional safety in rodents and mammals. In the present study, we evaluated its potential as an anticancer ... | 25,232,496 | [
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The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis. | Myc-interacting zinc finger protein 1 (Miz-1) is a BTB/POZ domain transcription factor that regulates complex processes such as proliferation and apoptosis. Constitutively Miz-1-deficient animals arrest embryonic development at E14.5 due to severe anemia and fetal liver cells lacking Miz-1 show a high cell death rate a... | 25,232,500 | [
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Somatic complaints in frontotemporal dementia. | Frontotemporal dementia (FTD) is associated with a broad spectrum of clinical characteristics. The objective of this study was to analyze the prevalence of unexplained somatic complaints in neuropathologically verified FTD. We also examined whether the somatic presentations correlated with protein pathology or regional... | 25,232,513 | [
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Epicardium Formation as a Sensor in Toxicology. | Zebrafish (<iDanio</i rerio) are an excellent vertebrate model for studying heart development, regeneration and cardiotoxicity. Zebrafish embryos exposed during the temporal window of epicardium development to the aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-<ip</i-dioxin (TCDD) exhibit severe hea... | 25,232,532 | [
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Interspinous posterior devices: What is the real surgical indication? | Interspinous posterior device (IPD) is a term used to identify a relatively recent group of implants used to treat lumbar spinal degenerative disease. This kind of device is classified as part of the group of the dynamic stabilization systems of the spine. The concept of dynamic stabilization has been replaced by that ... | 25,232,541 | [
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A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors. | Prenatal ethanol exposure (PNEE) has been linked to widespread impairments in brain structure and function. There are a number of animal models that are used to study the structural and functional deficits caused by PNEE, including, but not limited to invertebrates, fish, rodents, and non-human primates. Animal models ... | 25,232,537 | [
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Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia. | To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper e... | 25,232,548 | [
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Pneumatosis cystoides intestinalis associated with toxic epidermal necrolysis: A case report. | Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction, which is characterized by erythema, blisters, and/or erosions of the mucous membranes and skin, but intestinal involvement is rare. In contrast, pneumatosis cystoides intestinalis (PCI) is a rare condition associated with a wide variety of underlying d... | 25,232,553 | [
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Champagne bottle neck sign in a patient with Moyamoya syndrome. | The champagne bottle neck (CBN) sign refers to a reduction in the diameter of the proximal portion of the internal carotid artery that resembles a CBN, and is a characteristic feature of Moyamoya disease. A 43-year-old woman with an infarction of the posterior limb of the left internal capsule was diagnosed with Moyamo... | 25,232,554 | [
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Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study. | Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpose of this ... | 25,232,560 | [
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Early detection of left ventricular contractility abnormalities by two-dimensional speckle tracking strain in Chagas’ disease. | Chagas' disease is an important cause of heart failure, and early identification of cardiac involvement may help to identify patients at risk for disease progression. Two-dimensional (2D) speckle tracking (ST) strain seems to be a useful tool to detect incipient ventricular dysfunction. This study aims to analyze if 2D... | 25,232,573 | [
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The taxonomic status of badgers (Mammalia, Mustelidae) from Southwest Asia based on cranial morphometrics, with the redescription of Meles canescens. | The Eurasian badgers (Meles spp.) are widespread in the Palaearctic Region, occurring from the British Islands in the west to the Japanese Islands in the east, including the Scandinavia, Southwest Asia and southern China. The morphometric variation in 30 cranial characters of 692 skulls of Meles from across the Palaear... | 25,232,583 | [
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New records of gonodactylids (Crustacea: Stomatopoda: Gonodactylidae) from the Pacific Coast of Mexico with remarks on the morphology of Neogonodactylus lalibertadensis (Schmitt, 1940). | Eight species of the genus Neogonodactylus have been reported from the eastern Pacific. Up to now, only three of these species have been collected in Mexican waters: Neogonodactylus stanschi (Schmitt, 1940), N. lalibertadensis (Schmitt, 1940), and N. zacae (Manning, 1972). Recent sampling of stomatopods in several loca... | 25,232,595 | [
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A new genus of highly specialized ants in Cretaceous Burmese amber (Hymenoptera: Formicidae). | A new genus of ants, Zigrasimecia Barden and Grimaldi, is described for a new and uniquely specialized species, Z. tonsora Barden and Grimaldi n.sp., preserved in Cretaceous amber from Myanmar. The amber is radiometrically dated at 99 myo. Zigrasimecia is closely related to another basal genus of ants known only in Bur... | 25,232,618 | [
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Glyptothorax igniculus, a new species of sisorid catfish (Teleostei: Siluriformes) from Myanmar. | Glyptothorax igniculus, new species, is described from the Chindwin River system (part of the Irrawaddy River drainage) in northwestern Myanmar. It differs from other species of Glyptothorax in the Irrawaddy drainage except G. burmanicus in having a thoracic adhesive apparatus with a lanceolate central depression that ... | 25,232,627 | [
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Description of the nymph of Massartella alegrettae Ulmer, 1943 (Ephemeroptera: Leptophlebiidae: Atalophlebiinae) with a key to Massartella Lestage, 1930 nymphs. | The South American genus Massartella Lestage, 1930 is composed of five species. Massartella alegrettae Ulmer, 1943 is the only species with the nymph unknown. In this paper, we describe the nymph of M. alegrettae based on specimens from the state of São Paulo, Brazil. This is the first record of the species from southe... | 25,232,630 | [
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Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications. | Magnetic hyperthermia uses AC stimulation of magnetic nanoparticles to generate heat for cancer cell destruction. Whilst nanoparticles produced inside magnetotactic bacteria have shown amongst the highest reported heating to date, these particles are magnetically blocked so that strong heating occurs only for mobile pa... | 25,232,657 | [
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Site-specific growth of AgPd nanodendrites on highly purified Au bipyramids with remarkable catalytic performance. | Au nanorods have been extensively explored in various applications as the template for heterogeneous metallic nanostructures. However, Au bipyramids (AuBPs) have been paid much less attention although they possess an intriguing crystalline structure and extremely superior plasmonic properties which are absent in AuNRs.... | 25,232,660 | [
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Antimicrobial activity of Antarctic bryozoans: an ecological perspective with potential for clinical applications. | The antimicrobial activity of Antarctic bryozoans and the ecological functions of the chemical compounds involved remain largely unknown. To determine the significant ecological and applied antimicrobial effects, 16 ether and 16 butanol extracts obtained from 13 different bryozoan species were tested against six Antarc... | 25,232,675 | [
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A novel index of hypoxemia for assessment of risk during procedural sedation. | Procedural sedation is essential for many procedures. Sedation has an excellent safety profile; however, it is not without risks. Assessment of risk using clinical outcomes in clinical studies is difficult due to their rare occurrence. Therefore, surrogate end points are frequently used in a clinical study in lieu of c... | 25,232,693 | [
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Challenges and opportunities of microRNAs in lymphomas. | MicroRNAs (miRNAs) are small non-coding RNAs that control the expression of many target messenger RNAs (mRNAs) involved in normal cell functions (differentiation, proliferation and apoptosis). Consequently their aberrant expression and/or functions are related to pathogenesis of many human diseases including cancers. H... | 25,232,701 | [
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Cerebral tissue oxygenation during the initiation of venovenous ECMO. | In an acute respiratory distress syndrome, venovenous extracorporeal membrane oxygenation (vvECMO) can rapidly normalize arterial hypoxemia and carbon dioxide tension (PaCO2). Considering the positive relationship between PaCO2 and cerebral blood flow, the aim of the current study was to evaluate cerebral regional tiss... | 25,232,765 | [
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Conservative management of type II and III odontoid fractures in the elderly at a regional spine centre: A prospective and retrospective cohort study. | The optimal management of odontoid fractures in the elderly population is unclear and management of this group of patients is complicated by multiple co-morbidities. This study aimed to determine the outcomes after conservative management strategies were applied in this patient group. We carried out retrospective and p... | 25,232,807 | [
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A new approach for monitoring ebolavirus in wild great apes. | Central Africa is a "hotspot" for emerging infectious diseases (EIDs) of global and local importance, and a current outbreak of ebolavirus is affecting multiple countries simultaneously. Ebolavirus is suspected to have caused recent declines in resident great apes. While ebolavirus vaccines have been proposed as an int... | 25,232,832 | [
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Novel copy-number variants in a population-based investigation of classic heterotaxy. | Heterotaxy is a clinically and genetically heterogeneous disorder. We investigated whether screening cases restricted to a classic phenotype would result in the discovery of novel, potentially causal copy-number variants. We identified 77 cases of classic heterotaxy from all live births in New York State during 1998-20... | 25,232,849 | [
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Naked bodies, naked genomes: the special (but not exceptional) nature of genomic information. | Genetic exceptionalism, the view that genomic information is different from other types of sensitive information and deserves exceptional types of protections, has been roundly criticized. However, the public still expresses special fears about the access others might have to their genomic information. In this article,... | 25,232,853 | [
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The effect of leaf litter cover on surface runoff and soil erosion in Northern China. | The role of leaf litter in hydrological processes and soil erosion of forest ecosystems is poorly understood. A field experiment was conducted under simulated rainfall in runoff plots with a slope of 10%. Two common types of litter in North China (from Quercus variabilis, representing broadleaf litter, and Pinus tabula... | 25,232,858 | [
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Effects of experimental tooth clenching on pain and intramuscular release of 5-HT and glutamate in patients with myofascial TMD. | It has been suggested that tooth clenching may be associated with local metabolic changes, and is a risk factor for myofascial temporomandibular disorders (M-TMD). This study investigated the effects of experimental tooth clenching on the levels of 5-HT, glutamate, pyruvate, and lactate, as well as on blood flow and pa... | 25,232,860 | [
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Parents' Analgesic Trade-Off Dilemmas: How Analgesic Knowledge Influences Their Decisions to Give Opioids. | Ineffective analgesic decisions in the home may jeopardize the safety and comfort of children, yet little is known about factors influencing parental decisions. This study explored how parents' analgesic understanding influenced their hypothetical decisions to give opioids when faced with important trade-off dilemmas w... | 25,232,863 | [
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Implanting a Nonpulsatile Axial Flow Left Ventricular Assist Device as a Bridge to Transplant for Systemic Ventricular Failure After A Mustard Procedure. | Right (systemic) ventricular failure is well described after a Mustard procedure for transposition of the great arteries. Sixty-one percent of patients have been reported to show moderate-to-severe dysfunction of the systemic ventricle, 25 years after repair of transposition of the great arteries by a Mustard procedure... | 25,232,871 | [
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Concussion: key stakeholders and multidisciplinary participation in making sports safe. | As unstructured play declines, organized sports leagues have become a highly popular form of physical activity in young people. As concussive injuries are garnering increased media attention and public awareness, there is a growing concern for athlete safety. Although athletic trainers and physicians play a large role ... | 25,232,875 | [
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Establishing a clinical service for the management of sports-related concussions. | The clinical management of sports-related concussions is a specialized area of interest with a lack of empirical findings regarding best practice approaches. The University of Pittsburgh Medical Center Sports Concussion Program was the first of its kind; 13 years after its inception, it remains a leader in the clinical... | 25,232,886 | [
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Sideline assessment tools for the evaluation of concussion in athletes: a review. | Sports-related concussions, which have become more prevalent in the past decade, are an extremely common phenomenon in organized athletics and create a substantial economic burden on the health care system. Furthermore, they can have devastating impacts on the athletic careers and long-term health of athletes. However,... | 25,232,887 | [
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Boron-doped manganese dioxide for supercapacitors. | The addition of boron as a dopant during the reaction between carbon fiber and permanganate led to significant enhancement of the growth-rate and formation of the porous framework. The doped MnO2 was superior to the pristine sample as electrode materials for supercapacitors in terms of the specific capacitance and rate... | 25,232,909 | [
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0.3131085,
-0.1062637,
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0.1763288,
-0.08978061,
-0.07334... |
Enhanced synergism of thermo-chemotherapy by combining highly efficient magnetic hyperthermia with magnetothermally-facilitated drug release. | A magnetothermally-responsive nanocarrier was developed for efficient thermo-chemotherapy by combining efficient magnetic hyperthermia (MH) and magnetothermally-facilitated drug release. The effective magnetothermal-response contributed to high enhancement of tumor cell killing by an operating mechanism involving MH-fa... | 25,232,926 | [
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0.1273764,
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0.08722285,
0.04899058... |
Sortase A induces Th17-mediated and antibody-independent immunity to heterologous serotypes of group A streptococci. | Group A streptococci (GAS) are associated with a variety of mucosal and invasive human infections. Recurrent infections by highly heterologous serotypes indicate that cross-serotype immunity is critical for prevention of GAS infections; however, mechanisms underlying serotype-independent protection are poorly understoo... | 25,232,948 | [
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Effects of multidisciplinary rehabilitation on chronic fatigue in multiple sclerosis: a randomized controlled trial. | Several rehabilitation programmes aim at reducing the impact of fatigue in MS patients. Acute and chronic fatigue should require different management. To assess the effects of individually tailored, multidisciplinary outpatient rehabilitation (MDR) on chronic fatigue. Forty-eight ambulatory MS patients with chronic fat... | 25,232,955 | [
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Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. | Polycystic ovary syndrome (PCOS) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. This study aimed to investigate the hypothesis that the levels of putative periodontal pathogens in saliva and their antibody response in serum are elevat... | 25,232,962 | [
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Personality effects on romantic relationship quality through friendship quality: a ten-year longitudinal study in youths. | This study examined whether individuals with different personality types (i.e., overcontrollers, undercontrollers, resilients) had different friendship quality development throughout adolescence. It also investigated whether personality types were indirectly related to romantic relationship quality in young adulthood, ... | 25,232,964 | [
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0.04202975,
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Scarless gene deletion in methylotrophic Hansenula polymorpha by using mazF as counter-selectable marker. | With increasing application of Hansenula polymorpha in fundamental research and biotechnology, many more genetic manipulations are required. However, these have been restricted for the finiteness of selectable markers. Here, MazF, a toxin protein from Escherichia coli, was investigated as a counter-selectable marker in... | 25,233,001 | [
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PCN pincer palladium(II) complex catalyzed enantioselective hydrophosphination of enones: synthesis of pyridine-functionalized chiral phosphine oxides as NC(sp(3))O pincer preligands. | A series of chiral PCN pincer Pd(II) complexes VI-XIII with aryl-based aminophosphine-imidazoline or phosphinite-imidazoline ligands were synthesized and characterized. They were examined as enantioselective catalysts for the hydrophosphination of enones. Among them, complex IX, which features a Ph2PO donor as well as ... | 25,233,005 | [
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0.229... |
Benefit and adherence of the disease management program "diabetes 2": a comparison of Turkish immigrants and German natives with diabetes. | There is an ongoing debate about equity and equality in health care, and whether immigrants benefit equally from services as the non-immigrant population. The study focuses on benefits from and adherence to the diabetes mellitus type 2 (DM 2) disease management program (DMP) among Turkish immigrants in Germany. So far,... | 25,233,016 | [
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Enhancement in photocatalytic activity of NiO by supporting onto an Iranian clinoptilolite nano-particles of aqueous solution of cefuroxime pharmaceutical capsule. | NiO/nano-clinoptilolite (NiO-NCP) was prepared by ion exchanging process of the prepared ball-mill nano-clinoptilolite particles with nickel(II) chloride aqueous solution. The prepared composite was characterized by XRD, UV-Vis DRS, TEM and FT-IR and then used as a catalyst in the photodegradation of cefuroxime (CF) us... | 25,233,023 | [
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Impact of sediment characteristics on the heavy metal concentration and their ecological risk level of surface sediments of Vaigai river, Tamilnadu, India. | The distributions of the metals (Al, Fe, Mg, Cd, Cr, Cu, Ni, Pb and Zn) were measured for the surface sediments of the Vaigai river, Tamilnadu, India. These values are compared with different standard values to assess the level of toxicity of the heavy metals in the sediments. Risk indices (CF, PLI and PER) are also ca... | 25,233,032 | [
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Triggering protein adsorption on tailored cationic cellulose surfaces. | The equipment of cellulose ultrathin films with BSA (bovine serum albumin) via cationization of the surface by tailor-made cationic celluloses is described. In this way, matrices for controlled protein deposition are created, whereas the extent of protein affinity to these surfaces is controlled by the charge density a... | 25,233,035 | [
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Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children. | A questionnaire has been used repeatedly in cross-sectional studies to determine the prevalence of asthma, allergic rhinoconjunctivitis (AR) and eczema among schoolchildren in Nordland County, Norway. The current study was designed to validate the questionnaire against clinical assessment as the diagnostic gold standar... | 25,233,047 | [
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0.2053445,
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0.2194142,
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Switching and redox isomerism in first-row transition metal complexes containing redox active Schiff base ligands. | The reversible redox isomerisms in first row transition metal complexes of the type ML2 were studied. The six ML2 complexes (M = Mn(III) (), Fe(II) (), Co(III) (), Ni(II) (), Cu(II) () and Zn(II) ()) were synthesized with a redox active Schiff base ligand [2-(3,5-di-tert-butyl-2-hydroxyphenylamino)-4-chlorophenol] (H3L... | 25,233,051 | [
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... |
General slowing of lexical and nonlexical information processing in dementia of the Alzheimer type. | Individuals with very mild and mild dementia of the Alzheimer type (DAT) and age-matched controls performed three lexical and three nonlexical speeded information-processing tasks. The DAT group was slower than the control group on all six tasks. As predicted by general slowing (Nebes & Brady, 1992), most main effe... | 25,233,058 | [
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... |
Undertreatment of dyslipidemia: from the Arabian Gulf to the USA. Time to solve this problem! | Undertreatment of dyslipideamia is a universal problem and reduces the efficasy of hypolipidaemic drugs to reduce cardiovascular event rates. The means to face this problem are available and should be utilized to optimize dyslipidaemia control and clinical outcomes. | 25,233,064 | [
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0.01896865,
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0.1166785,
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Central nervous system germ cell tumors: an update. | Malignant germ cell tumors in the central nervous system are rare and not well known because they occur mainly in adolescents, an age in which patients are dispersed in adult and pediatric wards. Their biology starts to be unraveled by high-throughput genomics and their treatment is now well defined thanks to internati... | 25,233,069 | [
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Development and validation of the inventory of perceptions of medication administration errors for nurses in Taiwan. | Medication administration errors (MAEs) account for most medication errors, which not only threaten the safety of patients and increase hospital medical costs but also damage the personal and professional development of affected nurses. A feasible instrument measures the perceptions of committing an MAE that may provid... | 25,233,070 | [
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Mechanisms of chemical cooperative carcinogenesis by epidermal Langerhans cells. | Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled meats. Langerha... | 25,233,073 | [
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0.07007716,
0.3468063,
0.2086179,
0.1265255,
0.3556633,
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-0.... |
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