title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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N-acyl-homoserine lactones-producing bacteria protect plants against plant and human pathogens. | The implementation of beneficial microorganisms for plant protection has a long history. Many rhizobia bacteria are able to influence the immune system of host plants by inducing resistance towards pathogenic microorganisms. In this report, we present a translational approach in which we demonstrate the resistance-indu... | 25,234,390 | [
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Do we need primer for orthodontic bonding? A randomized controlled trial. | To evaluate the clinical performance of APC™II Victory Series™ (3M Unitek) brackets in direct orthodontic bonding with and without the use of primer. A single-operator, two-centre prospective, non-inferiority randomized controlled clinical trial. The Orthodontic departments at the Leeds Dental Institute and St Luke's H... | 25,234,405 | [
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Tunable thermodynamic stability of Au-CuPt core-shell trimetallic nanoparticles by controlling the alloy composition: insights from atomistic simulations. | A microscopic understanding of the thermal stability of metallic core-shell nanoparticles is of importance for their synthesis and ultimately application in catalysis. In this article, molecular dynamics simulations have been employed to investigate the thermodynamic evolution of Au-CuPt core-shell trimetallic nanopart... | 25,234,428 | [
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Neutral nuclear variation in Baboons (genus Papio) provides insights into their evolutionary and demographic histories. | Baboons (genus Papio) are distributed over most of sub-Saharan Africa and in the southern portion of the Arabian Peninsula. Six distinct morphotypes, with clearly defined geographic distributions, are recognized (the olive, chacma, yellow, Guinea, Kinda, and hamadryas baboons). The evolutionary relationships among babo... | 25,234,435 | [
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A modified Mediterranean diet score is associated with a lower risk of incident metabolic syndrome over 25 years among young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) study. | The Mediterranean diet has been reported to be inversely associated with incident metabolic syndrome (MetSyn) among older adults; however, this association has not been studied in young African American and white adults. The objective of the present study was to evaluate the association of a modified Mediterranean diet... | 25,234,439 | [
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Central blockade of nitric oxide transmission impairs exercise-induced neuronal activation in the PVN and reduces physical performance. | The blockade of central nitric oxide (NO) signaling modifies the thermoregulatory and metabolic adjustments that occur during exercise, thereby impairing physical performance. However, the brain areas involved in this response remain unknown. Nitrergic neurons are present in the hypothalamic areas that are activated du... | 25,234,442 | [
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Efficient In vitro labeling rabbit bone marrow-derived mesenchymal stem cells with SPIO and differentiating into neural-like cells. | Mesenchymal stem cells (MSCs) can differentiate into neural cells to treat nervous system diseases. Magnetic resonance is an ideal means for cell tracking through labeling cells with superparamagnetic iron oxide (SPIO). However, no studies have described the neural differentiation ability of SPIO-labeled MSCs, which is... | 25,234,466 | [
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Cognitive set shifting deficits and their relationship to repetitive behaviors in autism spectrum disorder. | The neurocognitive impairments associated with restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD) are not yet clear. Prior studies indicate that individuals with ASD show reduced cognitive flexibility, which could reflect difficulty shifting from a previously learned response pattern or a fail... | 25,234,483 | [
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Comparative analysis of histone H3 and H4 post-translational modifications of esophageal squamous cell carcinoma with different invasive capabilities. | Eukaryotic DNA is packaged into a chromatin with the help of four core histones (H2A, H2B, H3, and H4). Diverse histone post-translational modifications (PTMs) are hence involved in the regulation of gene transcription. However, how this regulation does work is still poorly understood and lacks details. Here we used th... | 25,234,497 | [
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Cervical conisation and the risk of preterm delivery: a retrospective matched pair analysis of a German cohort. | Since the routine screening program for cervical dysplasia by Pap smear was established in the early 1970s, the rate of cervical cancer has continually dropped. Even if a high percentage of cervical dysplasia shows spontaneous restitution, the only effective therapy for persisting cervical dysplasia is local ablation o... | 25,234,516 | [
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Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America. | It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination... | 25,234,519 | [
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Surgical management of the buccal bifurcation cyst: bone grafting as a treatment adjunct to enucleation and curettage. | The buccal bifurcation cyst (BBC) is a rare inflammatory odontogenic cyst of unknown etiology. It typically develops on the buccal aspect of the permanent mandibular first molar and occasionally on the permanent mandibular second molar in children 4 to 14 years old. Distinct clinical findings of the BBC include involve... | 25,234,530 | [
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Computer-aided trauma simulation system with haptic feedback is easy and fast for oral-maxillofacial surgeons to learn and use. | Computer-assisted surgical (CAS) planning tools have become widely available in craniomaxillofacial surgery, but are time consuming and often require professional technical assistance to simulate a case. An initial oral and maxillofacial (OM) surgical user experience was evaluated with a newly developed CAS system feat... | 25,234,531 | [
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RPTPs in axons, synapses and neurology. | Receptor-like protein tyrosine phosphatases represent a large protein family related to cell adhesion molecules, with diverse roles throughout neural development in vertebrates and invertebrates. This review focuses on their roles in axon growth, guidance and repair, as well as more recent findings demonstrating their ... | 25,234,542 | [
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The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor. | Formation of the factor VIIa (FVIIa)-tissue factor (TF) complex triggers the blood coagulation cascade. Using a structure-based rationale, we investigated how the length of the linker region between the two epidermal growth factor (EGF)-like domains in FVIIa influences TF binding and the allosteric activity enhancement... | 25,234,571 | [
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Can biomarkers differentiate pain and no pain subgroups of nonverbal children with cerebral palsy? A preliminary investigation based on noninvasive saliva sampling. | Assessing and treating pain in nonverbal children with developmental disabilities are a clinical challenge. Current assessment approaches rely on clinical impression and behavioral rating scales completed by proxy report. Given the growing health relevance of the salivary metabolome, we undertook a translational-orient... | 25,234,580 | [
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Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. | Fourteen self-reported insomniacs (SRI) and 14 good sleepers (GS) had their cardiac neuronal activity assessed by heart rate variability (HRV) under controlled respiration at a slow frequency rate of 0.1 Hz, and a forced rate of 0.2 Hz during daytime rest. Nighttime sleep was measured by polysomnography. The SRI showed... | 25,234,581 | [
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Photoionization mass spectrometric measurements of initial reaction pathways in low-temperature oxidation of 2,5-dimethylhexane. | Product formation from R + O2 reactions relevant to low-temperature autoignition chemistry was studied for 2,5-dimethylhexane, a symmetrically branched octane isomer, at 550 and 650 K using Cl-atom initiated oxidation and multiplexed photoionization mass spectrometry (MPIMS). Interpretation of time- and photon-energy-r... | 25,234,586 | [
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Towards an in vitro model mimicking the foreign body response: tailoring the surface properties of biomaterials to modulate extracellular matrix. | Despite various studies to minimize host reaction following a biomaterial implantation, an appealing strategy in regenerative medicine is to actively use such an immune response to trigger and control tissue regeneration. We have developed an in vitro model to modulate the host response by tuning biomaterials' surface ... | 25,234,587 | [
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Gamma-aminobutyric acid induces tumor cells apoptosis via GABABR1·β-arrestins·JNKs signaling module. | Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in central nervous system, has yet been found to widely exist in tumor tissues to regulate tumor cells growth. However, the function of GABA on inducing tumor cells apoptosis and the potential mechanism are still unclear. In order to detect whether GABA via... | 25,234,615 | [
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Evaluating cost when selecting performance reference compounds for the environmental deployment of polyethylene passive samplers. | A challenge in environmental passive sampling is determining when equilibrium is achieved between the sampler, target contaminants, and environmental phases. A common approach is the use of performance reference compounds (PRCs) to estimate target contaminant sampling rates and indicate degree of sampler equilibrium. O... | 25,234,621 | [
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Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin. | A common critical cellular event that many human enveloped viruses share is the requirement for proteolytic cleavage of the viral glycoprotein by furin in the host secretory pathway. For example, the furin-dependent proteolytic activation of highly pathogenic (HP) influenza A (infA) H5 and H7 haemagglutinin precursor (... | 25,234,642 | [
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Differential shift in spatial bias over time depends on observers׳ initial bias: Observer subtypes, or regression to the mean? | Healthy subjects typically exhibit a subtle bias of visuospatial attention favouring left space that is commonly termed 'pseudoneglect'. This bias is attenuated, or shifted rightwards, with decreasing alertness over time, consistent with theoretical models proposing that pseudoneglect is a result of the right hemispher... | 25,234,646 | [
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Pharmacokinetic and pharmacodynamic evaluation of elosulfase alfa, an enzyme replacement therapy in patients with Morquio A syndrome. | Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfatase, an enzyme required for degradation of the glycosaminoglycan keratan sulfate. Enzyme replacement therapy with elosulfase alfa provides a potential therapy for Morquio A syndr... | 25,234,648 | [
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Tongue carcinoma infrequently harbor common actionable genetic alterations. | Oral tongue squamous cell carcinomas (TSCC) are a unique subset of head and neck cancers with a distinct demographic profile, where up to half of the cases are never smokers. A small proportion of patients with OSCC are known to respond to EGFR TKI. We used a high-sensitivity mass spectrometry-based mutation profiling ... | 25,234,657 | [
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Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS. | The aim of this study was to identify characteristics associated with the presence and development of extra-articular manifestations (EAMs) in a prevalence cohort of patients with AS. Twelve-year follow-up data from the Outcome in Ankylosing Spondylitis International Study (OASIS) were used. In addition, medical charts... | 25,234,663 | [
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Outcomes of primary percutaneous coronary intervention in ST-segment elevation myocardial infarction patients with previous coronary bypass surgery. | This study sought to determine the contemporary clinical characteristics and outcomes of patients with ST-segment elevation myocardial infarction (STEMI) and previous coronary artery bypass graft (CABG), including those with a saphenous vein graft culprit lesion. The outcome of STEMI patients with previous CABG is repo... | 25,234,670 | [
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Sustained heterozygosity across a self-incompatibility locus in an inbred ascidian. | Because self-incompatibility loci are maintained heterozygous and recombination within self-incompatibility loci would be disadvantageous, self-incompatibility loci are thought to contribute to structural and functional differentiation of chromosomes. Although the hermaphrodite chordate, Ciona intestinalis, has two sel... | 25,234,703 | [
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Characterization of natural organic colorants in historical and art objects by high-performance liquid chromatography. | High-performance liquid chromatography plays an important role in analysis of historical organic colorants. A number of papers have been published in this field over the last 30 years. Classification of the most commonly used natural dyes and an overview of high-performance liquid chromatography methods with main focus... | 25,234,708 | [
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MiR99a modulates MMP7 and MMP13 to regulate invasiveness of Kaposi's sarcoma. | Matrix metalloproteinases (MMPs) and microRNAs (miRNAs) are associated with Kaposi's sarcoma (KS) tumorigenesis. To date, the molecular basis underlying crosstalk of MMPs and miRNAs in KS remains unexplored. From the resected KS samples, we detected significant correlation of miRNA99a (miR99a), with MMP7 and MMP13, but... | 25,234,715 | [
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New insights in cellular and molecular aspects of BM niche in chronic myelogenous leukemia. | Hematoproliferative neoplasias like chronic myelogenous leukemia (CML) progressively affect bone marrow niche; however, there are only few specific clinical markers for prediction of disease progression. Here, we review the myeloproliferative niche and molecular changes including signaling pathways as well as microRNA ... | 25,234,716 | [
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Overexpression of CaDSR6 increases tolerance to drought and salt stresses in transgenic Arabidopsis plants. | The partial CaDSR6 (Capsicum annuum Drought Stress Responsive 6) cDNA was previously identified as a drought-induced gene in hot pepper root tissues. However, the cellular role of CaDSR6 with regard to drought stress tolerance was unknown. In this report, full-length CaDSR6 cDNA was isolated. The deduced CaDSR6 protein... | 25,234,727 | [
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Comparative safety profiles of intravitreal bevacizumab, ranibizumab and pegaptanib: the analysis of the WHO database of adverse drug reactions. | The purpose of this study is to conduct a comparative analysis of the suspected adverse drug reactions (ADRs) associated with intravitreal bevacizumab, ranibizumab and pegaptanib in the WHO database in order to have a real-life information on these drugs, which now is only based on data coming from clinical trials. ADR... | 25,234,795 | [
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Characterisation and impact of reported and unreported exacerbations: results from ATTAIN. | The frequency and impact of exacerbations identified using healthcare resource utilisation (HCRU) or the EXAcerbations of Chronic pulmonary disease Tool (EXACT) were compared prospectively in a 24-week, phase III trial (ATTAIN). Patients with moderate-to-severe chronic obstructive pulmonary disease received twice-daily... | 25,234,803 | [
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Mexican immigrant women reaching out: the role of informal networks in the process of seeking help for intimate partner violence. | More inquiry is needed into how Mexican immigrant survivors of intimate partner violence (IPV) are seeking help, to improve interventions designed to reach this isolated and vulnerable population. This grounded theory study, using a sample of 29 Mexican immigrant survivors of IPV and 15 key informants, examines the hel... | 25,234,812 | [
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Brown skin disease: A syndrome of dysecdysis in Puerto Rican crested toads (Peltophryne lemur). | The endangered Puerto Rican crested toad (Peltophryne [Bufo] lemur) has been held and bred in zoos for release into protected areas in Puerto Rico since 1982. In 2004, several cases of a novel syndrome of skin changes in toads were noticed at the Toronto Zoo. A total of 21 toads were found to have similar lesions and t... | 25,234,808 | [
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Coronary endothelial dysfunction is associated with inflammation and vasa vasorum proliferation in patients with early atherosclerosis. | Endothelial dysfunction is an early manifestation of atherosclerosis. Inflammation and vasa vasorum play a pivotal role in the pathophysiology of plaque initiation, development, and complications. Optical coherence tomography allows high-resolution imaging of tissue microstructure. Therefore, the aim of this study was ... | 25,234,815 | [
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Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling. | Self-assembling heparin nanoparticles have attracted much attention as promising drug carriers for various drugs, genes and imaging agents. In the present investigation, we found that heparin nanoparticles are selective Toll-like receptor 4 (TLR-4) antagonists and have a much greater anti-inflammatory effect than nativ... | 25,234,820 | [
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Assessment of myocardial infarct size with body surface potential mapping: validation against contrast-enhanced cardiac magnetic resonance imaging. | Assessment of myocardial infarct (MI) size is important for therapeutic and prognostic reasons. We used body surface potential mapping (BSPM) to evaluate whether single-lead electrocardiographic variables can assess MI size. We performed BSPM with 120 leads covering the front and back chest (plus limb leads) on 57 pati... | 25,234,825 | [
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Outcomes of HER2-positive early breast cancer patients in the pre-trastuzumab and trastuzumab eras: a real-world multicenter observational analysis. The RETROHER study. | Addition of trastuzumab to adjuvant chemotherapy has dramatically reduced the risk of recurrence and has become the standard of care for human epidermal growth factor receptor 2 (HER2)-positive early breast cancer patients. Since most data on trastuzumab benefits come from clinical trials, conducted in selected patient... | 25,234,842 | [
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Photoelectrochemical reduction of aqueous protons with a CuO|CuBi2O4 heterojunction under visible light irradiation. | A p-type heterojunction photoelectrode consisting of platinized CuBi2O4 layered on a CuO film was prepared. The CuO|CuBi2O4|Pt electrode photo-generates H2 in pH neutral aqueous solution during visible light irradiation and exhibits a substantially enhanced photocurrent compared to CuO|Pt and CuBi2O4|Pt electrodes. Red... | 25,234,857 | [
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Pleuroparenchymal fibroelastosis and non-specific interstitial pneumonia: frequent pulmonary sequelae of haematopoietic stem cell transplantation. | Pulmonary sequelae, reported as chronic graft-versus-host disease (cGVHD), of haematopoietic stem cell transplantation (HSCT) include constrictive bronchiolitis obliterans (CBO), lymphocytic bronchiolitis (LB), and veno-occlusive disease (VOD); recently, pleuroparenchymal fibroelastosis (PPFE) has also been described i... | 25,234,860 | [
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Acoustic mode coupling induced by nonlinear internal waves: evaluation of the mode coupling matrices and applications. | This paper applies the mode coupling equation to calculate the mode-coupling matrix for nonlinear internal waves appearing as a train of solitons. The calculation is applied to an individual soliton up to second order expansion in sound speed perturbation in the Dyson series. The expansion is valid so long as the fract... | 25,234,871 | [
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Examining the robustness of automated aural classification of active sonar echoes. | Active sonar systems are used to detect underwater man-made objects of interest (targets) that are too quiet to be reliably detected with passive sonar. Performance of active sonar can be degraded by false alarms caused by echoes returned from geological seabed structures (clutter) in shallow regions. To reduce false a... | 25,234,872 | [
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The role of syntax in maintaining the integrity of streams of speech. | This study examined the ability of listeners to utilize syntactic structure to extract a target stream of speech from among competing sounds. Target talkers were identified by voice or location, which was held constant throughout a test utterance, and paired with correct or incorrect (random word order) target sentence... | 25,234,885 | [
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Dynamic adjustment of echolocation pulse structure of big-footed myotis (Myotis macrodactylus) in response to different habitats. | Studying relationships between characteristics of sonar pulses and habitat clutter level is important for the understanding of signal design in bat echolocation. However, most studies have focused on overall spectral and temporal parameters of such vocalizations, with focus less on potential variation in frequency modu... | 25,234,900 | [
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Loudness summation using focused and unfocused electrical stimulation. | With a cochlear implant, when stimulation from multiple channels is interleaved, the perceived loudness is greater than the loudness associated with any of the individual channels presented in isolation. This phenomenon is known as loudness summation. This study examined if loudness summation with monopolar and tripola... | 25,234,912 | [
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Learning to discriminate frequency modulation rate can benefit and worsen pitch acuity. | Participants were trained to discriminate frequency modulation rates (FM-rate training) or Gabor patch orientations (visual training) in a same-different task for two different training lengths. Test discriminations involved trains of FM sweeps with identical modulation rates, but different frequencies. FM-rate trainin... | 25,234,915 | [
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Non-classical nonlinear feature extraction from standard resonance vibration data for damage detection. | Dynamic non-classical nonlinear analyses show promise for improved damage diagnostics in materials that exhibit such structure at the mesoscale, such as concrete. In this study, nonlinear non-classical dynamic material behavior from standard vibration test data, using pristine and frost damaged cement mortar bar sample... | 25,234,919 | [
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Access to care for adolescents seeking weight loss surgery. | Adolescents seeking weight loss surgery (WLS) frequently encounter obstacles obtaining treatment authorization from insurance carriers. This study identified factors influencing authorization for adolescents with clinical indications for WLS. A retrospective review was conducted for adolescents with clinical indication... | 25,234,923 | [
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Pneumocystis pneumonia (PCP) and Pneumocystis jirovecii carriage in renal transplantation patients: a single-centre experience. | The Pneumocystis pneumonia is an increasing problem in transplanted patients: up to 25% suffer from Pneumocystis pneumonia, occurring during the first 6 months after transplantation. From 2001 to 2009, we investigated 21 patients with pneumonia after renal transplantation for the presence of Pneumocystis jirovecii. The... | 25,234,937 | [
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Histological evolution of pleuroparenchymal fibroelastosis. | To investigate the histological evolution in the development of pleuroparenchymal fibroelastosis (PPFE). We examined four patients who had undergone surgical lung biopsy twice, or who had undergone surgical lung biopsy and had been autopsied, and in whom the histological diagnosis of the first biopsy was not PPFE, but ... | 25,234,959 | [
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A quasianalytical time domain solution for scattering from a homogeneous sphere. | A transient spherical multipole expansion-like solution for acoustic scattering from a spherical object is derived within a mesh-free and singularity-free time domain integral equation (TDIE) framework for the sound-soft, sound-rigid and penetrable cases. The method is based on an expansion of the time domain Green's f... | 25,234,967 | [
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The origins of ambient biological sound from coral reef ecosystems in the Line Islands archipelago. | Although ambient biological underwater sound was first characterized more than 60 years ago, attributing specific components of ambient sound to their creators remains a challenge. Noise produced by snapping shrimp typically dominates the ambient spectra near tropical coasts, but significant unexplained spectral variat... | 25,234,977 | [
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Influence and interactions of laryngeal adductors and cricothyroid muscles on fundamental frequency and glottal posture control. | The interactions of the intrinsic laryngeal muscles (ILMs) in controlling fundamental frequency (F0) and glottal posture remain unclear. In an in vivo canine model, three sets of intrinsic laryngeal muscles-the thyroarytenoid (TA), cricothyroid (CT), and lateral cricoarytenoid plus interarytenoid (LCA/IA) muscle comple... | 25,235,003 | [
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0.03309356,
0.02330061,
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Direct generation of 2-ps blue pulses from gain-switched InGaN VCSEL assessed by up-conversion technique. | Ultra-short pulses in blue region generated from compact and low-cost semiconductor lasers have attracted much attention for a wide variety of applications. Nitride-based vertical-cavity surface-emitting lasers (VCSELs), having intrinsic high material gain and short cavities, favor the generation of ultra-short blue pu... | 25,236,162 | [
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Halopyrroles: a new group of highly toxic disinfection byproducts formed in chlorinated saline wastewater. | Utilizing seawater for toilet flushing is an effective way to conserve freshwater in coastal cities. During chlorination for disinfecting saline wastewater effluents, the high levels of bromide from seawater are oxidized to hypobromous acid which may then react with effluent organics to form brominated disinfection byp... | 25,236,171 | [
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0.06... |
Quo vadis: advanced prostate cancer-clinical care and clinical research in the era of multiple androgen receptor-directed therapies. | The novel androgen receptor-directed therapies abiraterone acetate and enzalutamide, having demonstrated improved survival in randomized phase 3 studies of men with metastatic castration-resistant prostate cancer, have ushered in a new era in the treatment of this disease. Additional novel androgen receptor-directed th... | 25,236,176 | [
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Ablation of focal atrial tachycardia from the non-coronary aortic cusp: case series and review of the literature. | Focal atrial tachycardia successfully ablated from the non-coronary cusp (NCC) is rare. Our aim was to describe the characteristics of mapping and ablation therapy of NCC focal atrial tachycardias and to provide a comprehensive review of the literature. Seven patients (age 40 ± 9 years) with symptomatic, drug-refractor... | 25,236,180 | [
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Data calibration and reduction allows to visualize behavioural profiles of psychosocial influences in mice towards clinical domains. | Psychosocial stress-particularly in combination with genetic vulnerability-is a critical environmental risk factor for psychiatric diseases in humans. Isolation rearing (IR) and social defeat (SD) paradigms model psychosocial risk factors in rodents, while enriched environment (EE) protects them from behavioural defici... | 25,236,183 | [
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A pharmaceutical industry perspective on the economics of treatments for alcohol and opioid use disorders. | Individuals with alcohol and/or drug use disorders often fail to receive care, or evidence-based care, yet the literature shows health economic benefits. Comparative effectiveness research is emerging that examines approved approaches in terms of real, total healthcare cost/utilization. Comprehensive retrospective insu... | 25,236,185 | [
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Asparagine in plums detected by CEST-MRI. | Magnetic resonance imaging (MRI) relies on the topological distribution of the intense water NMR signal and may be used to report about changes in the internal structures of fruits associated to ripening, storing, pathogen infection. Herein the use of CEST-MRI (chemical exchange saturation transfer) is introduced to sh... | 25,236,190 | [
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Chemical and sensory comparison of fresh and dried lulo (Solanum quitoense Lam.) fruit aroma. | The odour-active volatile compounds of lulo fruit (Solanum quitoense Lam.) were isolated by solvent extraction followed by solvent-assisted flavour evaporation (SAFE). GC-O and GCMS analyses as well as quantitation by internal standard method showed that (Z)-3-hexenal, ethyl butanoate, 3-sulphanylhexyl acetate, and eth... | 25,236,202 | [
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Variability in chemical composition of Vitis vinifera cv Mencía from different geographic areas and vintages in Ribeira Sacra (NW Spain). | A chemical study was conducted from 2009 to 2012 to examine spatial and seasonal variability of red Vitis vinifera Mencía located in different geographic areas (Amandi, Chantada, Quiroga-Bibei, Ribeiras do Sil and Ribeiras do Miño) from NW Spain. Mencía samples were analysed for phenolic, (flavan-3-ols, flavonols, anth... | 25,236,215 | [
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Application of FTIR-ATR spectroscopy to the quantification of sugar in honey. | A Fourier transform infrared spectroscopic method with attenuated total reflectance (FTIR-ATR) and partial least squares (PLS) regression model for the prediction of sugar content in honey samples was calculated. Standards of trehalose, glucose, fructose, sucrose, melezitose, turanose and maltose were used to identify ... | 25,236,219 | [
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Separation and determination of 4-methylimidazole, 2-methylimidazole and 5-hydroxymethylfurfural in beverages by amino trap column coupled with pulsed amperometric detection. | A method for simultaneous determination of 4-methylimidazole (4-MeI), 2-methylimidazole (2-MeI) and 5-hydroxymethylfurfural (HMF) in beverages was developed using solid-phase extraction (SPE) and amino trap column coupled with pulsed amperometric detection (AMTC-PAD). A single amino trap column (P/N: 046122) was first ... | 25,236,220 | [
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Effects of postharvest curing treatment on flesh colour and phenolic metabolism in fresh-cut potato products. | The flesh colour and phenolic metabolism in potato tuber during curing and after cut were investigated. Result indicated that postharvest curing not only changed phenolic metabolism during curing, but also improved fresh-cut colour for 12 days after fresh cut. Significantly lower PAL and higher phenolic content and PPO... | 25,236,223 | [
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A multiplex real-time PCR method for the quantification of beef and pork fractions in minced meat. | One popular staple food in many lands is minced meat, traditionally prepared from beef and/or pork fractions. While beef is the more expensive of the two meat fractions, the possibility exists for manufacturers to fraudulently declare higher proportions of it. Additionally, the need exists to protect consumers who, out... | 25,236,231 | [
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Enzymatic synthesis of 3-O-α-maltosyl-l-ascorbate using an engineered cyclodextrin glucanotransferase. | A mutant derived from a cyclodextrin glucantransferase with an alanine residue as its acid/base catalyst residue (CGT-E284A) catalyzed regioselective glycosylation at 3-OH of l-ascorbic acid using α-maltosyl fluoride (αG2F) and l-ascorbic acid as the donor and acceptor, respectively, yielding 3-O-α-maltosyl-l-ascorbate... | 25,236,239 | [
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White tea (Camellia sinensis) inhibits proliferation of the colon cancer cell line, HT-29, activates caspases and protects DNA of normal cells against oxidative damage. | Tea (Camellia sinensis) is one of the most consumed beverages in the world. White tea is made from the buds and young leaves of the tea plant which are steamed and dried, whilst undergoing minimal oxidation. The MTT assay was used to test the extract on the effect of the proliferation of the colorectal cancer cell line... | 25,236,244 | [
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Gonad-infecting species of Philometra (Nematoda: Philometridae) from groupers Epinephelus spp. (Osteichthyes: Serranidae) in the Bay of Bengal, India. | Based on light and scanning electron microscopical studies, two new and one specifically not identified gonad-infecting species of Philometra Costa, 1845 (Nematoda: Philometridae) are described from the ovary of marine fishes of the genus Epinephelus Bloch (Serranidae, Perciformes) in the Bay of Bengal, off the eastern... | 25,236,267 | [
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A new species of Cacatuocotyle (Monogenea, Dactylogyridae) parasitizing two species of Astyanax (Ostariophysi, Characidae) in southern Brazil. | A new species of Cacatuocotyle is described from the external surface of Astyanax aff. fasciatus and Astyanax jacuhiensis from Lake Guaíba, State of Rio Grande do Sul, Brazil. It differs from the other three species of the genus, recorded from Mexico and the State of Paraná, Brazil, by possessing an accessory piece wit... | 25,236,274 | [
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The first clinically manifested case of angiostrongylosis in a dog in Slovakia. | The first clinical case of canine angiostrongylosis from Slovakia, previously infection-free country, is described. 18-month old male Bernese mountain dog living in south-eastern part of Slovakia showed poor health condition characterized by weight loss, irritating cough, dispnoe, intense salivation, vomiting and bilat... | 25,236,277 | [
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On a new species of Aplectana (Nematoda, Cosmocercidae) from Kulti, Burdwan, West Bengal, India. | During routine survey for amphibian nematodes from coalfield areas of West Bengal, India 7 male and 12 female nematodes were recovered from the rectum of one out of three Duttaphrynus melanostictus (Schneider, 1899) examined for helminth infection from Kulti, Burdwan. On examination the recovered nematodes were found t... | 25,236,282 | [
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0.32832... |
Understanding medication oversupply and its predictors in the outpatient departments in Thailand. | Medication oversupply is an important problem in the healthcare systems. It causes unnecessary avoidable healthcare costs. Although some studies have determined the magnitude and financial loss due to medication oversupply in western countries, they may not be applicable to Asia-pacific countries. This study aims to de... | 25,236,345 | [
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An investigation of factors that impact patients' subjective experience of nurse-led clinics: a qualitative systematic review. | To systematically review the qualitative evidence on factors that affect the experience of patients attending nurse-led clinics and compare with key elements of person-centred care. As the number of nurse-led clinics increases in response to health system needs, evaluation has focused on clinical outcomes and cost. Pat... | 25,236,376 | [
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Is magnetite a universal memory molecule? | Human stem cells possess memory, and consequently all living human cells must have a memory system. How memory is stored in cells and organisms is an open question. Magnetite is perhaps the best candidate to be a universal memory molecule. Magnetite may give us a clue, because it is the Earth's most distributed and imp... | 25,236,401 | [
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Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells. | Epidermal growth factor receptor (EGFR) overexpression and prognostic value in head and neck squamous cell cancer is the basis for targeting by anti-EGFR antibodies, which increase the efficacy of radiotherapy. In order to evaluate the best therapeutic schedule, the effects of cetuximab (C225) on Hep-2 cell proliferati... | 25,236,402 | [
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Differential stress response in rats subjected to chronic mild stress is accompanied by changes in CRH-family gene expression at the pituitary level. | The purpose of this study was to examine molecular markers of the stress response at the pituitary and peripheral levels in animals that responded differently to chronic mild stress (CMS). Rats were subjected to 2-weeks CMS and symptoms of anhedonia was measured by the consumption of 1% sucrose solution. mRNA levels of... | 25,236,411 | [
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Global evolution of Equidae and Gomphotheriidae from South America. | The contemporary South American mammalian communities were determined by the emergence of the Isthmus of Panama and by the profound climatic oscillations during the Pleistocene. Horses and gomphotheres were 2 very conspicuous groups of immigrant mammals from North America that arrived in South America during the Pleist... | 25,236,414 | [
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A multifunctional 3D chiral porous ferroelectric metal-organic framework for sensing small organic molecules and dye uptake. | A flexible aromatic multicarboxylate ligand and Cd(II) ions assemble into a chiral multihelical porous metal-organic framework with second-order nonlinear optical and ferroelectric properties. The obtained guest-free form highly selectively senses small organic molecules and adsorbs large dye molecules. | 25,236,428 | [
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0.09387385,
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Expression pattern of neuronal intermediate filament α-internexin in anterior pituitary gland and related tumors. | α-Internexin (INA) is a class IV neuronal intermediate filament protein that maintains the morphogenesis of neurons. It is expressed in developing neuroblasts and represents the major component of the cytoskeleton in cerebellar granule cells of adult central nervous system tissue. Data concerning INA expression in the ... | 25,236,435 | [
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0.1371298,
0.132255,
0.3240217,
0.1225873,
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-... |
Development of a Chronic Care Model for Neurological Conditions (CCM-NC). | Persons with neurological conditions and their families face a number of challenges with the provision of health and community-based services. The purpose of this study was to understand the existing health and community service needs and gaps in care and to use this information to develop a model to specify factors an... | 25,236,443 | [
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0.1849125,
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0.2227478,
0.1... |
Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. | Animals in nature are frequently challenged by toxic compounds, from those that occur naturally in plants as a defense against herbivory, to pesticides used to protect crops. On exposure to such xenobiotic substances, animals mount a transcriptional response, generating detoxification enzymes and transporters that meta... | 25,236,448 | [
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High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice. | Genetic influences on anxiety disorders are well documented; however, the specific genes underlying these disorders remain largely unknown. To identify quantitative trait loci (QTL) for conditioned fear and open field behavior, we used an F2 intercross (n = 490) and a 34th-generation advanced intercross line (AIL) (n =... | 25,236,452 | [
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Bayesian modeling of haplotype effects in multiparent populations. | A general Bayesian model, Diploffect, is described for estimating the effects of founder haplotypes at quantitative trait loci (QTL) detected in multiparental genetic populations; such populations include the Collaborative Cross (CC), Heterogeneous Socks (HS), and many others for which local genetic variation is well d... | 25,236,455 | [
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0.059114... |
Lessons from the contraceptive CHOICE project: the Hull long-acting reversible contraception (LARC) initiative. | To discover whether a hand-out explaining the benefits of intrauterine contraceptives (IUCs) and implants could increase their uptake in Hull, UK. We developed a simple double-sided A4 hand-out. On one side was a script with pictures of copper and levonorgestrel IUCs next to a 20 pence coin and of an implant beside a h... | 25,236,471 | [
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S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells. | Intracellular calprotectin (S100A8/A9) functions in the control of the cell cycle checkpoint at G2/M. Dysregulation of S100A8/A9 appears to cause loss of the checkpoint, which frequently characterizes head and neck squamous cell carcinoma (HNSCC). In the present study, we analyzed carcinoma cells for other S100A8/A9-di... | 25,236,491 | [
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MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis. | Reactive oxygen species (ROS) have a crucial role in melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24)-induced cancer cell apoptosis. However, cancer cell has a series of protective mechanisms to resist ROS damage. Nuclear factor erythroid 2-related factor 2 (Nrf2) activates antioxidant response... | 25,236,495 | [
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... |
Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle. | The role of molecular methods in the diagnosis of head and neck cancer is rapidly evolving and holds great potential for improving outcomes for all patients who suffer from this diverse group of malignancies . However, there is considerable debate as to the best clinical approaches, particularly for Next Generation Seq... | 25,236,499 | [
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0.19... |
Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms. | Overexpression of high mobility group AT-hook 2 (Hmga2), which is negatively regulated by MIRLET7 micro RNAs through 3'-untranslated region (3'UTR), causes proliferative haematopoiesis mimicking myeloproliferative neoplasms (MPNs) and contributes to progression of myelofibrosis in mice. Thus, we investigated HMGA2 mRNA... | 25,236,537 | [
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0.1159526,
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Fe(III) nucleation in the presence of bivalent cations and oxyanions leads to subnanoscale 7 Å polymers. | Highly disordered Fe(III) phases formed in the presence of bivalent cations and oxyanions represent important components of the global Fe cycle due to their potential for rapid turnover and their critical roles in controlling the speciation of major and trace elements. However, a poor understanding of the formation pat... | 25,236,538 | [
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0.2291506,
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Electrocardiographic changes announcing the rapid development of apical hypertrophic cardiomyopathy in an adult male. | We presented the case of an adult male without structural heart disease, who in the period of 3 years developed apical hypertrophic cardiomyopathy. ECG changes preceded the development of ventricular hypertrophy. We discussed the appearance of ventricular enlargement during adulthood, in some cases of hypertrophic card... | 25,236,565 | [
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0.2744599,
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Nonpharmacotherapeutic Somatic Treatments for Bipolar Disorder (ECT, DBS, rTMS). | Nonpharmacotherapeutic, somatic treatments play an essential role in the management of bipolar disorder (BPD). Studies indicate that electroconvulsive therapy (ECT) is an effective treatment for acute mania, bipolar depression, and mixed affective states. Furthermore, it is an important second-line treatment option, as... | 25,236,561 | [
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Evaluation of a quantitative RT-PCR assay to detect HER2 mRNA overexpression for diagnosis and selection of trastuzumab therapy in breast cancer tissue samples. | Breast cancer patients who have a positive result for HER2 overexpression are commonly treated with Herceptin, a HER2-targeted therapy. In the present study, the BrightGen HER2 RT-qDx (Syantra, Calgary, Canada), which is based on a one-tube nested RT-qPCR method that detects HER2 mRNA overexpression, was clinically eva... | 25,236,569 | [
0.2800519,
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... |
Analysis of microRNA expression signatures in malignant pleural mesothelioma, pleural inflammation, and atypical mesothelial hyperplasia reveals common predictive tumorigenesis-related targets. | Pleural chronic inflammation (PP) and mesothelial hyperplasia (HP) may be critical to the development of malignant pleural mesothelioma (MPM). Nonetheless, studies searching for mechanistic links involving microRNA (miRNA) regulation among these interrelated processes have not been reported. Using PCR-Array, we identif... | 25,236,577 | [
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0.1969563,
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... |
In vitro characterization and in vivo behavior of human nucleus pulposus and annulus fibrosus cells in clinical-grade fibrin and collagen-enriched fibrin gels. | The intervertebral disc (IVD) presents a limited self-repair ability and cell-based therapies have been suggested to prevent or treat IVD lesions. Fibrin-based scaffolds as cell carriers are promising candidates in IVD tissue engineering, thanks to their ability to be easily delivered into the defect and to adapt to th... | 25,236,589 | [
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0.2188067,
0.2645685,
0.1809954,
0.00354314... |
Anti-diabetic effects of polysaccharides from Talinum triangulare in streptozotocin (STZ)-induced type 2 diabetic male mice. | The present study evaluated the anti-diabetic effects of the polysaccharides obtained from Talinum triangulare (TTP). Two TTP doses (150 mg/kg and 300 mg/kg · bw/d) were administered orally to normal and streptozotocin (STZ)-induced type 2 diabetic male Kunming mice, respectively. The TTP hypoglycemic and hypolipidemic... | 25,236,607 | [
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Cheonggukjang polysaccharides enhance immune activities and prevent cyclophosphamide-induced immunosuppression. | Cheonggukjang is a traditional Korean fermentation product prepared from soybean that is reported to have various biological functions. We previously reported that the polysaccharides from Cheonggukjang (PSCJ) have immunostimulatory activities in RAW 264.7 macrophages and primary cultured splenocytes. In this study, th... | 25,236,609 | [
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The cultural environment behind successful maternal death and morbidity reviews. | This paper discusses some of the background principles which, through wide experience of instituting reviews of maternal deaths or near-misses around the world, appear common to their successful introduction. A supportive culture at personal, institutional and national level underpinned by the fostering of professional... | 25,236,630 | [
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0.03745722,
0.04189442,
0.3058293,
-0.0681... |
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