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HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury.
In this study, we evaluated the effect of astragaloside IV (Ast IV) post-ischemia treatment on myocardial ischemia-reperfusion (IR) injury (IRI). We also examined whether hypoxia inducible factor-1α (HIF-1α) and its downstream gene-inducible nitric oxide (NO) synthase (iNOS) play roles in the cardioprotective effect of...
25,238,237
[ -0.3693608, 0.0145284, 0.3017258, -0.04264946, -0.1062553, -0.1860661, 0.05525727, -0.1551598, 0.1225255, -0.1365593, 0.5277269, 0.6460831, -0.4283935, -0.07617058, -0.2725514, -0.05674831, -0.4471739, 0.2225253, -0.3131661, 0.1672746, -0.165044, 0.2687669, -0.2814763, ...
GSK2374697, a novel albumin-binding domain antibody (AlbudAb), extends systemic exposure of exendin-4: first study in humans--PK/PD and safety.
GSK2374697 is a genetically engineered fusion protein of a human domain antibody to exendin-4. This molecule binds with a high affinity to human serum albumin, creating a long-duration glucagon-like peptide-1 (GLP-1) receptor agonist. This study is the first evaluation of the albumin-binding domain antibody (AlbudAb) d...
25,238,251
[ 0.1206622, -0.3498076, -0.3824441, -0.3780193, 0.1030789, -0.1306131, -0.199107, 0.3816095, 0.1467381, -0.06129362, 0.1033222, -0.3871482, -0.06630127, -0.05479187, -0.1216887, -0.118231, -0.6453165, 0.2620335, -0.06329892, 0.1592884, -0.02814841, 0.2911138, -0.07460473, ...
Association between vitamin D level and viral load or fibrosis stage in chronic hepatitis B patients from Southern China.
The role of vitamin D playing in patients with chronic hepatitis C has been intensively studied. However, studies on the potential interaction between vitamin D level and chronic hepatitis B are still limited. This study aimed to explore whether any association existed between serum vitamin D level and liver histology ...
25,238,258
[ -0.07568701, 0.1574963, 0.001951687, 0.139293, 0.07541016, -0.02068891, -0.06095258, 0.3900723, -0.05561382, 0.1729608, 0.1913584, 0.2084067, 0.1169004, 0.168904, -0.2255061, -0.3252071, 0.1382075, 0.1042708, 0.09039292, 0.3807422, -0.1429022, 0.1324299, -0.1457036, -0....
The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.
PIM kinases are a family of serine/threonine kinases involved in cell survival and proliferation. There is significant structural similarity between the three PIM kinases (PIM1, PIM2 and PIM3) and only few amino acid differences. Although, several studies have specifically monitored the role of PIM1 in tumorigenesis, m...
25,238,262
[ -0.1982688, -0.1094536, -0.1243503, -0.5281478, 0.1343368, -0.04014714, 0.1737317, 0.329419, 0.01334708, -0.02654709, -0.00923047, -0.1213121, -0.2623044, 0.02532756, -0.1287248, -0.1474802, 0.04010519, -0.0085477, -0.2713538, 0.2349504, 0.4197956, 0.3112552, -0.1450431, ...
Chemical Mass Balance model applied to an olfactory annoyance problematic.
The source-receptor model Chemical Mass Balance (CMB) generally used for air pollution studies is applied for the first time to solve odor signature issues. The olfactory annoyance perceived at a receptor site of an industrial area is often the result of a combination of different smells, emitted by several industrial ...
25,238,272
[ -0.1111535, 0.002434714, 0.1482691, -0.1890972, 0.03461051, -0.1537418, -0.2869579, -0.06532637, 0.1502346, -0.3318599, -0.1671632, -0.2765025, -0.05790744, 0.09411649, -0.2686094, 0.2021217, -0.3649005, 0.3444898, 0.3213955, 0.1098533, -0.06910973, 0.6335556, 0.007331872...
A naked-eye and ratiometric near-infrared probe for palladium via modulation of a π-conjugated system of cyanines.
A ratiometric and colorimetric cyanine-based palladium sensor with an excellent selectivity and sensitivity has been designed. Notably, the modulation of π-conjugated electrons in cyanine dyes can result in a ratiometric fluorescence change with a large Stokes shift (270 nm), especially for realizing palladium detectio...
25,238,274
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Hepatocellular carcinoma: can circulating tumor cells and radiogenomics deliver personalized care?
The 'omics revolution is facilitating a personalized approach to improving outcome by refining diagnosis, staging, treatment, and monitoring of hepatocellular carcinoma. Furthermore, the promise of being able to target a range of specific tumor drivers at a molecular level offers exciting new therapy prospects for a di...
25,238,287
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Personality and psychological correlates of eating disorder symptoms among male collegiate athletes.
Despite a proliferation of research on disordered eating in female athletes, few studies have included male athletes. The purpose of this study was to determine which of five personality and psychological variables of interest (i.e., perfectionism, self-esteem, optimism, reasons for exercise, and appearance orientation...
25,238,289
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The process of Danish nurses' professionalization and patterns of thought in the 20th century.
In this article, we address how the professionalization process is reflected in the way Danish nursing textbooks present 'nursing' to new members of the profession during the 20th century. The discussion is based on a discourse analysis of seven Danish textbooks on basic nursing published between 1904 and 1996. The ana...
25,238,323
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Effects of background electrolytes and ionic strength on enrichment of Cd(II) ions with magnetic graphene oxide-supported sulfanilic acid.
To elucidate the influence mechanisms of background electrolytes and ionic strength on Cd(II) removal, the adsorption of Cd(II) onto magnetic graphene oxide-supported sulfanilic acid (MGO-SA) in aqueous solutions containing different types and concentrations of background electrolytes was studied. The results indicate ...
25,238,326
[ -0.1978357, 0.08133426, -0.1947236, 0.07661065, 0.02553267, 0.196234, -0.08038156, -0.05173068, -0.1219918, 0.07989664, -0.2278931, 0.07117018, 0.2889016, 0.05722898, -0.2176615, -0.06095481, -0.3369473, 0.1372808, 0.003963437, 0.1663857, 0.1440739, 0.02223732, -0.1185394...
Free energy of binding of cationic metal complexes to AuNPs through electron-transfer processes.
AuNP effects on the oxidation reaction of [Ru(NH3)5pz](2+) with S2O8(2-) were studied. Experimental results show the effects produced by gold nanoparticles of different sizes, which are then discussed by using an approach based on the two-state model. Changes in the observed reactivity are explained by a change in the ...
25,238,328
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Folate-decorated and reduction-sensitive micelles assembled from amphiphilic polymer-camptothecin conjugates for intracellular drug delivery.
It is one of the challenges for a wide clinical application of polymer micelles to address the structure disintegration and premature drug release before reaching a pathological site. In the current study, folic acid (FA)-decorated polymer-drug conjugates (FSC) were synthesized with disulfide linkages between camptothe...
25,238,329
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Search for trilepton nucleon decay via p→e+νν and p→μ+νν in the Super-Kamiokande experiment.
The trilepton nucleon decay modes p→e+νν and p→μ+νν violate |Δ(B-L)| by two units. Using data from a 273.4 kt yr exposure of Super-Kamiokande a search for these decays yields a fit consistent with no signal. Accordingly, lower limits on the partial lifetimes of τp→e+νν>1.7×10(32) years and τp→μ+νν>2.2×10(32) year...
25,238,348
[ -0.03123343, -0.3923074, -0.1325573, 0.1559072, 0.2065972, -0.132438, -0.3565913, 0.07710657, 0.1575513, -0.0413725, -0.09389142, 0.2088349, 0.2059182, 0.3345154, -0.6362312, -0.2715981, -0.2357733, 0.0996791, 0.1566128, 0.2820136, 0.3220091, 0.1745276, -0.1757803, 0.16...
Observation of high-energy astrophysical neutrinos in three years of IceCube data.
A search for high-energy neutrinos interacting within the IceCube detector between 2010 and 2012 provided the first evidence for a high-energy neutrino flux of extraterrestrial origin. Results from an analysis using the same methods with a third year (2012-2013) of data from the complete IceCube detector are consistent...
25,238,345
[ -0.02941828, -0.1851192, -0.403835, 0.02005934, 0.1205538, -0.2774564, -0.441246, -0.1450575, 0.1676276, -0.1415451, -0.265747, 0.2306086, 0.1484777, 0.07947544, -0.4498235, -0.2351079, -0.1787578, 0.2892387, 0.004723438, 0.09082378, 0.07967404, 0.3606852, -0.2673112, 0...
Low-energy photoelectrons in strong-field ionization by laser pulses with large ellipticity.
The 3D photoelectron momentum distributions created by the strong-field ionization of argon atoms and naphthalene molecules with intense, large ellipticity (∼0.7) femtosecond laser pulses are studied. The experiment reveals the presence of low-energy electrons for randomly oriented naphthalene, but not for argon. Our t...
25,238,357
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Segregation stabilizes nanocrystalline bulk steel with near theoretical strength.
Grain refinement through severe plastic deformation enables synthesis of ultrahigh-strength nanostructured materials. Two challenges exist in that context: First, deformation-driven grain refinement is limited by dynamic dislocation recovery and crystal coarsening due to capillary driving forces; second, grain boundary...
25,238,372
[ -0.1831659, 0.2460259, -0.05141512, -0.1174822, 0.2731622, -0.001454844, -0.2721299, -0.202766, -0.02434407, 0.09595114, -0.004976031, -0.3106686, -0.07080495, -0.04602218, -0.3967596, -0.1883045, -0.2371833, 0.07188292, -0.1183487, 0.07690033, 0.2078473, 0.06610853, -0.1...
Magnetic correlations and pairing in the 1/5-depleted square lattice Hubbard model.
We study the single-orbital Hubbard model on the 1/5-depleted square-lattice geometry, which arises in such diverse systems as the spin-gap magnetic insulator CaV4O9 and ordered-vacancy iron selenides, presenting new issues regarding the origin of both magnetic ordering and superconductivity in these materials. We find...
25,238,374
[ -0.3125833, 0.1362702, -0.2024856, -0.2100148, 0.03639141, -0.3514573, -0.376947, -0.3084096, 0.2376027, -0.123889, -0.2511148, 0.05068185, -0.2493193, 0.2666893, -0.5431283, -0.2621291, -0.5736045, -0.04739356, 0.3513438, 0.03740381, 0.1120691, 0.281263, -0.2037708, 0....
SNP mining in Crassostrea gigas EST data: transferability to four other Crassostrea species, phylogenetic inferences and outlier SNPs under selection.
Oysters, with high levels of phenotypic plasticity and wide geographic distribution, are a challenging group for taxonomists and phylogenetics. Our study is intended to generate new EST-SNP markers and to evaluate their potential for cross-species utilization in phylogenetic study of the genus Crassostrea. In the study...
25,238,392
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GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2.
The upstream stimulatory factor 2 (USF2) is a regulator of important cellular processes and is supposed to have also a role during tumor development. However, the knowledge about the mechanisms that control the function of USF2 is limited. The data of the current study show that USF2 function is regulated by phosphoryl...
25,238,393
[ 0.0940681, -0.2297939, -0.2875356, -0.2242413, 0.3379273, -0.2193119, -0.003821007, 0.2753884, 0.04126893, 0.2015866, 0.165265, 0.03886284, -0.2807706, -0.369742, -0.23663, 0.2112468, -0.149717, -0.1252774, -0.5888183, 0.2259379, 0.5928331, 0.1796719, -0.202597, 0.14479...
Alteration of antioxidant enzymes and associated genes induced by grape seed extracts in the primary muscle cells of goats in vitro.
This study was conducted to investigate how the activity and expression of certain paramount antioxidant enzymes respond to grape seed extract (GSE) addition in primary muscle cells of goats. Gluteal primary muscle cells (PMCs) isolated from a 3-week old goat were cultivated as an unstressed cell model, or they were ex...
25,238,394
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Major groove orientation of the (2S)-N(6)-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosine DNA adduct induced by 1,2-epoxy-3-butene.
1,3-Butadiene (BD) is an environmental and occupational toxicant classified as a human carcinogen. It is oxidized by cytochrome P450 monooxygenases to 1,2-epoxy-3-butene (EB), which alkylates DNA. BD exposures lead to large numbers of mutations at A:T base pairs even though alkylation of guanines is more prevalent, sug...
25,238,403
[ -0.2095668, 0.006905597, -0.2791206, -0.03427164, 0.1081784, -0.2491137, -0.1878842, -0.1191673, 0.1316249, 0.07130916, 0.08309335, 0.05006294, 0.2038274, 0.1638048, -0.5609268, -0.2590771, -0.3041275, 0.1599255, 0.2662283, 0.2759059, 0.413868, 0.4347578, -0.1740167, 0....
Robust concentration and frequency control in oscillatory homeostats.
Homeostatic and adaptive control mechanisms are essential for keeping organisms structurally and functionally stable. Integral feedback is a control theoretic concept which has long been known to keep a controlled variable A robustly (i.e. perturbation-independent) at a given set-point A(set) by feeding the integrated ...
25,238,410
[ -0.117855, 0.02825241, -0.1641423, -0.2573702, 0.06496884, -0.392958, -0.1462786, 0.1989913, 0.3165982, -0.02184191, -0.1919586, -0.07996953, -0.06058279, 0.1003247, -0.521242, -0.05793329, -0.2553314, -0.1183369, -0.06481325, 0.207332, 0.146461, 0.1345082, -0.1146733, ...
Time to culture conversion and regimen composition in multidrug-resistant tuberculosis treatment.
Sputum cultures are an important tool in monitoring the response to tuberculosis treatment, especially in multidrug-resistant tuberculosis. There has, however, been little study of the effect of treatment regimen composition on culture conversion. Well-designed clinical trials of new anti-tuberculosis drugs require thi...
25,238,411
[ -0.04494607, -0.1330072, -0.3626893, -0.1872137, -0.1497552, -0.09526997, -0.09164657, 0.2300763, 0.4050795, -0.1162426, -0.08201431, 0.03290408, 0.04893738, 0.1566768, -0.05379614, -0.1107277, -0.1596377, 0.1317936, -0.01713625, 0.2966497, 0.08993759, 0.02695376, -0.0854...
An efficient and provable secure revocable identity-based encryption scheme.
Revocation functionality is necessary and crucial to identity-based cryptosystems. Revocable identity-based encryption (RIBE) has attracted a lot of attention in recent years, many RIBE schemes have been proposed in the literature but shown to be either insecure or inefficient. In this paper, we propose a new scalable ...
25,238,418
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Off-pump tricuspid valved stent implantation: real-time three-dimensional transesophageal echocardiography for guidance and assessment.
In this case report, the value of real-time three-dimensional transesophageal echocardiography (TEE) for guidance and assessment of orthotopic tricuspid valved stent implantation in the beating heart is assessed in four pigs. A full two-dimensional TEE evaluation of standardized parameters was conducted. Three-dimensio...
25,238,420
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Anatomy-based eligibility measure for robotic-assisted bypass surgery.
Robotic-assisted endoscopic single-vessel small thoracotomy allows clinicians to perform coronary artery bypass grafting surgery in a minimally invasive manner using the da Vinci Surgical System. Not all patients are suitable for this technique, and the lack of an appropriate method for patient eligibility avoids compl...
25,238,423
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2- to 9-year outcome of stemmed total knee arthroplasty. Similar failure rates in patients when used primary or as a revision.
There is an increase in demand for primary and revision total knee joint procedures. We studied implant survival and functional outcome of patients operated with a constrained condylar knee (CCK) or a rotating hinge implant (RH) as a primary or a revision total knee arthoplasty (TKA). We evaluated clinically and radiog...
25,238,436
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Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses.
The objectives of this study were to evaluate the effects of two commercial feed supplements, Egusin 250® [E-250] and Egusin SLH® [E-SLH], on gastric ulcer scores, gastric fluid pH, and blood gas values in stall-confined horses undergoing feed-deprivation. Nine Thoroughbred horses were used in a three-period crossover ...
25,238,454
[ -0.008152694, -0.305232, -0.2191139, -0.1450978, 0.09764675, 0.1405262, 0.241504, -0.4029581, 0.103214, -0.3655864, -0.242498, 0.1900896, -0.1539754, -0.4768428, -0.02735081, -0.1135454, -0.5893626, 0.08281025, -0.2523634, 0.3378818, -0.2562376, 0.2247047, -0.0080693, -...
Role of renin-angiotensin system and metabolites of angiotensin in the mechanism of gastric mucosal protection.
Angiotensin II, the main effector of the renin-angiotensin system (RAS), is generated from the precursor angiotensinogen by the actions of renin, angiotensin-converting enzyme, chymase and various peptidases. RAS is essential in the control of blood pressure and body fluid homeostasis but their involvement in the mecha...
25,238,456
[ -0.2219336, -0.3103997, -0.2075261, -0.5193067, 0.2576924, -0.03450832, 0.07530382, -0.003554351, 0.2375692, 0.1720644, 0.2269324, -0.2476266, -0.04067284, -0.05609081, -0.590726, -0.001256823, -0.3272337, -0.02751207, 0.3078679, 0.06511699, -0.08067966, 0.07976407, -0.42...
Fully solution-processing route toward highly transparent polymer solar cells.
We report highly transparent polymer solar cells using metallic silver nanowires (AgNWs) as both the electron- and hole-collecting electrodes. The entire stack of the devices is processed from solution using a doctor blading technique. A thin layer of zinc oxide nanoparticles is introduced between photoactive layer and...
25,238,460
[ -0.1960946, 0.07336383, -0.1029938, -0.04422641, 0.1718743, -0.1204682, -0.4847884, 0.2211425, 0.1057383, 0.2010268, 0.04987231, -0.213216, 0.0245732, -0.1008587, -0.5428102, 0.127227, -0.5209283, 0.2393599, -0.3262865, 0.2870682, 0.4128231, 0.1768378, -0.003853541, 0.0...
[Hypoplasia of internal carotid artery associated with carotid paraganglioma. A case report and review of the literature].
Hypoplasia of the internal carotid artery is a rare congenital malformation. It has been mainly associated with aneurysms and other pathologies but not in association with paraganglioma. The incidence is 0.01% of all the anomalies of carotid vessels. Although the exact cause is unknown, it is thought to represent a seq...
25,238,472
[ -0.2157943, -0.1910488, -0.1337623, -0.08788731, 0.150194, -0.3426642, -0.3841257, -0.2508188, 0.2021184, 0.2914632, 0.1635012, 0.1203894, -0.3930387, -0.7884152, -0.3188386, -0.1306706, -0.4820955, 0.2156701, 0.1228042, 0.2809788, 0.2388236, -0.2135926, -0.1714762, 0.1...
[Solitary fibrous hemangiopericytoma of atypical location: importance of immunohistochemical study].
The rare cutaneous solitary fibrous tumor was initially described in the thoracic cavity in relation to the pleura and subsequently been associated with other serous membranes. It has been described in other extraserosal locations including the skin. Knowledge of its existence along with fairly typical histological fea...
25,238,475
[ -0.02176063, -0.1942852, -0.07606202, -0.4117115, -0.1708367, -0.5321551, -0.2812865, -0.207229, -0.04951223, 0.08682396, 0.1175898, -0.1052033, 0.08134147, -0.5067946, -0.6136712, -0.3406323, -0.3305902, -0.1623965, -0.0122633, -0.01579471, 0.3585035, -0.001629181, -0.14...
Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N.
Alternative splicing of pre-mRNA, catalyzed by small nuclear ribonucleoproteins (snRNPs), plays an important role in proteome complexity and the modulation of cellular functions. snRNP polypeptide N (SmN), is tissue-specifically expressed, where it replaces snRNP polypeptide B (SmB)/B' in the Sm core assembly of snRNPs...
25,238,490
[ -0.03887643, -0.03089377, -0.3477871, -0.1445668, -0.05690666, -0.3632513, 0.10667, 0.1085094, 0.2930377, -0.08193389, -0.1940601, -0.1501527, -0.0416936, -0.01630932, -0.221302, 0.08565684, -0.3307549, -0.1837714, 0.2053924, -0.1409855, 0.2811213, 0.2883006, 0.2618916, ...
Elucidating self-assembly mechanisms of uranyl-peroxide capsules from monomers.
Self-assembly of uranyl peroxide polyoxometalates (POMs) in alkaline peroxide solutions has been known for almost a decade, but in these dynamic solutions that contain high concentrations of base and peroxide the reaction pathway could never be discerned, mixed species are obtained, and reproducibility is sometimes a c...
25,238,533
[ -0.1117733, 0.2076464, -0.2006509, -0.1248722, 0.1463808, -0.4111622, -0.1808755, 0.07804244, 0.2948457, 0.2116166, -0.07512318, 0.0700082, 0.144656, -0.2889056, -0.4508074, 0.129409, -0.01385082, 0.2310855, 0.1348888, 0.004289899, 0.5122307, 0.07106743, -0.2629302, 0.1...
A capacitive DNA sensor-based test for simple and sensitive analysis of antibiotic resistance in field setting.
To meet urgent needs for solving serious worldwide drug-resistance problems, a sensitive label-free capacitive sensor developed in our group was investigated as a tool to be applied in the field of antibiotic resistance genotyping, for instance the detection of ampicillin resistance gene (ampR). Proof-of-concept data d...
25,238,540
[ 0.03561883, 0.09680211, 0.08493342, 0.1464808, -0.05899357, -0.03408201, -0.6947624, 0.3799664, 0.3725203, -0.01355515, 0.04774644, -0.1130353, -0.0003218685, 0.3194115, -0.4288656, -0.1031185, -0.3104751, 0.1804593, -0.56701, 0.3080956, 0.4565662, -0.1048291, -0.05105765...
The systemic inflammome of severe obesity before and after bariatric surgery.
Obesity is associated with low-grade systemic inflammation. The "inflammome" is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and...
25,238,542
[ 0.2794308, 0.2750168, 0.01400182, -0.2109689, 0.02815854, -0.1553219, -0.1789265, -0.1732202, 0.157139, 0.09275849, 0.02402888, -0.2663043, -0.1197164, -0.2871504, -0.1752248, -0.1127256, 0.001369172, 0.2907698, 0.4668159, 0.2080877, -0.0808425, 0.2340715, -0.2452888, -...
Hydride, gold(i) and related derivatives of the unsaturated ditungsten anion [W2Cp2(μ-PCy2)(μ-CO)2](-).
Protonation of the title anion with [NH4]PF6 gave [W2Cp2(H)(μ-PCy2)(CO)2] (), which in solution exists as an equilibrium mixture of two isomers having either bridging (major) or terminal (minor) hydrides. Both molecules retain short intermetallic distances (ca. 2.54 Å), with the H-bridged isomer being almost 15 kJ mol(...
25,238,551
[ 0.06994073, -0.05445154, -0.004076382, 0.05750399, 0.03640228, -0.1311241, -0.2581669, 0.004513467, 0.05993525, 0.1311934, -0.07933529, 0.1216035, 0.3896414, 0.02547479, -0.6181541, -0.2965566, -0.4380015, 0.1574314, 0.1385124, 0.2420233, -0.04476243, 0.2640527, -0.127447...
Reactive intermediate detection in real time via paper assisted thermal ionization mass spectrometry.
To capture reactive intermediates from bulk solution in real time, mass spectrometry with paper assisted thermal ionization has been developed. Two representative organic reactions, Eschweiler-Clarke methylation at high temperature and acid-catalyzed olefin dioxygenation at room temperature, were chosen as models to ev...
25,238,562
[ -0.2251596, 0.04210911, -0.1959026, 0.05903344, 0.1234702, -0.06166018, -0.1610896, 0.007374568, 0.1971817, -0.005068523, 0.07263835, 0.1385188, 0.4595005, 0.08179181, -0.2313617, -0.1710888, -0.5297973, 0.02900284, 0.02854841, 0.2720144, 0.2899233, 0.3865894, -0.3774813,...
Evaporation of a capillary bridge between a particle and a surface.
The liquid bridge that forms between a particle and a flat surface, and the dynamics of its evaporation are pertinent to a range of physical processes including paint and ink deposition, spray drying, evaporative lithography and the flow and processing of powders. Here, using time-lapse photography, we investigate the ...
25,238,574
[ 0.0326786, 0.2876956, 0.1010029, 0.170466, 0.02099194, -0.03123944, -0.1401327, -0.06507806, 0.3031358, 0.004647094, 0.04509316, -0.3464423, -0.2088461, -0.06900992, -0.3588431, 0.03685419, -0.08747658, 0.0006664513, 0.2471288, 0.07345317, 0.2565195, 0.1296927, -0.1458679...
Additivity of substituent effects in aromatic stacking interactions.
The goal of this study was to experimentally test the additivity of the electrostatic substituent effects (SEs) for the aromatic stacking interaction. The additivity of the SEs was assessed using a small molecule model system that could adopt an offset face-to-face aromatic stacking geometry. The intramolecular interac...
25,238,590
[ -0.1117143, 0.2767642, -0.02864994, -0.002493764, 0.2309714, -0.224716, -0.07857347, 0.0109014, 0.2652981, -0.1543012, -0.11206, -0.09816045, 0.1655441, 0.3069006, -0.202807, 0.112964, -0.4334368, 0.2346006, -0.2256715, 0.3420573, -0.2085869, -0.1280103, -0.1870376, -0....
Efficient molecular dynamics simulations of multiple radical center systems based on the fragment molecular orbital method.
The fully analytic energy gradient has been developed and implemented for the restricted open-shell Hartree-Fock (ROHF) method based on the fragment molecular orbital (FMO) theory for systems that have multiple open-shell molecules. The accuracy of the analytic ROHF energy gradient is compared with the corresponding nu...
25,238,592
[ -0.04136835, 0.1638611, -0.09259506, 0.1487607, 0.08902821, -0.1885148, 0.01371466, -0.1101872, 0.2883765, -0.03797486, -0.1576853, 0.06474937, -0.001068318, 0.3291825, -0.2229439, 0.02493791, -0.2308953, 0.2130517, 0.1061301, 0.1149518, 0.2467593, -0.08348867, -0.2459271...
Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes.
Dimethyl sulfoxide (DMSO) is a polar organic solvent that is used to dissolve neuroprotective or neurotoxic agents in neuroscience research. However, DMSO itself also has pharmacological and pathological effects on the nervous system. Astrocytes play a central role in maintaining brain homeostasis, but the effect and m...
25,238,609
[ -0.4664514, 0.08681662, 0.1566013, 0.2050739, 0.02617085, -0.2137066, -0.06596542, 0.03052999, 0.06264681, -0.180656, -0.0989165, 0.3870713, -0.1226215, 0.5154464, 0.03165411, 0.1637021, -0.3214198, 0.2352912, -0.4471861, 0.1009682, -0.1341568, 0.3325038, 0.02028088, 0....
Functional nanomaterials can optimize the efficacy of vaccines.
Nanoscale materials can improve the efficacy of vaccines. Herein we review latest developments that use nanomaterials for vaccines. By highlighting the relationships between the nanoscale physicochemical characteristics and working mechanisms of nanomaterials, this paper shows the current status of the developments whe...
25,238,620
[ -0.217378, 0.1012878, -0.02563422, -0.08816473, -0.1472165, -0.08274613, -0.1928544, 0.1431895, -0.03614495, 0.08586639, 0.09474722, -0.1555872, 0.2112908, 0.07600421, -0.5294737, -0.1240248, -0.05235448, -0.09025627, 0.06653717, 0.2693425, 0.03625368, 0.001522655, -0.180...
Pediatric endoscopic third ventriculostomy: a population-based study.
Endoscopic third ventriculostomy (ETV) is an alternative to ventriculoperitoneal shunting for hydrocephalus treatment. Choice of treatment options raises questions about which patients are likely to benefit from ETV. The authors performed a population-based analysis using an administrative claims database, examining cu...
25,238,625
[ 0.0791835, -0.1664586, -0.3704766, -0.3712676, 0.3478372, -0.4013041, 0.04263371, -0.1813348, -0.01248949, 0.2613777, 0.2458259, 0.3522652, -0.2282763, -0.3321194, 0.1984091, -0.1956477, -0.09134827, 0.3567672, -0.2747461, -0.4313258, -0.2328917, 0.04502375, -0.5153603, ...
A scientific comment on the welfare of domesticated ruminants slaughtered without stunning.
This review provides a scientific comment on the welfare of ruminants slaughtered by ventral-neck incision without stunning. Evidence is derived from studies of calves, sheep and goats. Reference is also made to findings in other mammals including humans. Pain is an inherently subjective experience and only indirect in...
25,238,631
[ -0.02484138, -0.02642514, -0.03136663, -0.3493933, -0.08480725, -0.4388006, -0.1940046, -0.06153962, 0.07343432, -0.3434623, -0.009583486, -0.5341309, -0.1625935, -0.3920611, 0.06976888, 0.06846486, -0.4632538, 0.1740308, 0.2034489, 0.1178929, -0.1132307, 0.2565451, -0.14...
Novel copper(II) complexes as new promising antitumour agents. A crystal structure of [Cu(1,10-phenanthroline-5,6-dione)2(OH2)(OClO3)](ClO4).
The cytotoxic properties of copper(II) complexes with 1,10-phenanthroline (phen) can be modified by substitution in the phen backbone. For this purpose, Cu(II) complexes with phen, 1,10-phenanthrolin-5,6-dione (phendione) and 1,10-phenanthrolin-5,6-diol (phendiol) have been synthesised and characterised. The crystal st...
25,238,635
[ -0.2577786, -0.2560528, 0.1776807, -0.2642629, -0.002494745, 0.1339011, -0.3113754, 0.1296877, 0.07528584, 0.314273, -0.105065, 0.5610019, 0.02694555, 0.1426962, -0.8914198, -0.2254522, -0.2248163, 0.2537879, -0.04260614, 0.966216, 0.2298814, 0.0833936, -0.1608457, 0.02...
Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice.
The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the...
25,238,637
[ 0.1404268, 0.09945737, -0.0512915, 0.06095783, 0.1797871, -0.02788268, 0.3435124, 0.3012297, -0.03898715, -0.1156885, -0.04434168, -0.08480357, 0.03013984, -0.2704651, -0.2805921, 0.3529319, -0.3196433, 0.2191035, 0.2458119, 0.2491275, -0.03323373, 0.5226439, -0.5851818, ...
Direct validation of the single step classical to quantum free energy perturbation.
The use of the Zwanzig equation in the calculation of single-step perturbations to provide first-principles (ab initio) quantum mechanics (QM) correction terms to molecular mechanics (MM) free energy cycles is well established. A rigorous test of the ability to converge such calculations would be very useful in this co...
25,238,649
[ -0.201088, 0.2224068, -0.079946, -0.2275659, 0.4310978, -0.419834, -0.1870285, 0.07970288, 0.3508194, 0.005209848, -0.3852425, 0.03257066, -0.02359627, 0.1544118, -0.5486602, -0.003827891, -0.2617481, -0.03434791, -0.1764886, 0.04831477, 0.4596764, -0.1594477, -0.08194286...
Mononuclear and tetranuclear compounds of yttrium and dysprosium ligated by a salicylic schiff-base derivative: synthesis, photoluminescence, and magnetism.
The Schiff-base (2-aminoethyl)hydroxybenzoic acid (H(2)L) as a proligand was prepared in situ from 3-formylsalicylic acid and ethanolamine (ETA). The mononuclear {[Y(HL)(4)][ETAH]·H(2)O} (1) and {[Dy(HL)(4)] [ETAH]·3MeOH·H(2)O} (2) and tetranuclear {[Y(4)(HL)(2)(L)(4)(μ(3)-OH)(2)]·4MeOH·4H(2)O} (3), {[Dy4(HL)(2)(L)(4)(...
25,238,652
[ 0.01527559, 0.03309886, 0.09897154, 0.03023921, 0.02160365, -0.201726, -0.1037242, -0.2278829, 0.179844, -0.1055704, -0.2300598, 0.17785, 0.2791786, -0.04435554, -0.626452, -0.03376612, -0.2652442, 0.02353108, -0.07862819, 0.3529162, 0.359751, 0.239305, -0.1710695, 0.04...
Transcriptional profiling of the lectin ArathEULS3 from Arabidopsis thaliana toward abiotic stresses.
The family of EUL-related lectins groups all proteins with an Euonymus lectin (EUL) domain, a protein motif which is highly conserved throughout the plant kingdom and occurs as part of many chimeric proteins with different domain architectures. The S3 type EUL lectin from Arabidopsis thaliana (ArathEULS3) has become th...
25,238,657
[ 0.3279786, 0.07531563, 0.09930516, -0.1193209, 0.2991666, 0.05373859, -0.08319797, -0.07069935, 0.0366073, -0.08530793, 0.04705143, 0.0747143, -0.005321731, -0.1861569, -0.0288671, 0.4851737, -0.4286426, 0.384509, -0.2771192, -0.1679581, 0.7935385, 0.268688, -0.3017267, ...
Surveillance of health care-associated infections in a tertiary hospital neonatal intensive care unit in Egypt: 1-year follow-up.
Reported rates of neonatal health care-associated infections (HAIs) in neonatal intensive care units (NICUs) have risen rapidly in recent years. Little data are available in Egypt, however. The aim of the present study was to determine the incidence of and risk factors for HAIs in the NICU of Ain Shams University Hospi...
25,238,664
[ 0.09099015, -0.5135379, -0.2613538, -0.08840808, -0.07821934, 0.0612791, 0.02115204, -0.03304585, -0.1938623, -0.0206786, -0.06720695, -0.1463092, -0.06035528, 0.06831391, 0.02013219, -0.1547196, -0.4329983, 0.2349923, 0.2434991, -0.4483764, 0.05655725, 0.1534763, -0.0847...
Cerebrospinal fluid oxidative stress marker levels and cytokine concentrations in a neonate with incontinentia pigmenti.
Some children with incontinentia pigmenti exhibit encephalopathic features with severe seizures and disturbed consciousness, from the neonatal through the early infantile period. However, the pathological mechanism of brain lesion development is not fully understood. We measured the cerebrospinal fluid levels of cytoki...
25,238,668
[ -0.1234433, -0.1301982, 0.1375888, -0.6101569, 0.2796398, -0.4794092, 0.02054243, -0.4432656, -0.06957138, 0.1822509, -0.02179137, 0.680558, -0.1772536, 0.132285, 0.08966605, -0.2650206, -0.3809584, 0.3349251, 0.322364, -0.08145114, 0.2395243, 0.01729671, -0.1861402, -0...
Maternal health issues and cardio-metabolic outcomes in the offspring: a focus on Indigenous populations.
Non-communicable diseases (NCDs) including diabetes, obesity and cardiovascular disease are the leading causes of death worldwide. Indigenous populations are disproportionally affected. In an effort to halt the increasing disease burden, the mechanisms underlying the increasing rate of NCDs are an important area of stu...
25,238,683
[ -0.3164477, -0.1935564, -0.1468229, 0.1185715, -0.03911335, -0.1535322, -0.03938949, 0.1385094, 0.1448571, 0.2383255, -0.1449841, -0.002702225, 0.08517576, -0.07864372, -0.3646421, -0.07376906, -0.3344083, 0.2866575, -0.2497074, -0.3163192, -0.06126565, 0.2995815, -0.3133...
In-vivo evaluation of the kinematic behavior of an artificial medial meniscus implant: A pilot study using open-MRI.
In this pilot study we wanted to evaluate the kinematics of a knee implanted with an artificial polycarbonate-urethane meniscus device, designed for medial meniscus replacement. The static kinematic behavior of the implant was compared to the natural medial meniscus of the non-operated knee. A second goal was to evalua...
25,238,685
[ -0.1465876, 0.551719, 0.08180412, 0.1560208, -0.2563264, -0.235383, -0.1777833, 0.127343, -0.3326368, 0.09112772, 0.07541953, -0.4389773, 0.07519297, -0.3192092, -0.3826963, 0.1081802, -0.140677, 0.4210305, -0.4966304, -0.08774292, 0.2504134, -0.1826746, 0.2762362, 0.12...
Significance of perivesical lymph nodes in radical cystectomy for bladder cancer.
The location of positive lymph nodes (LNs) is important for bladder cancer staging. Little is known regarding the impact of perivesical (PV) lymph node (PVLN) involvement on survival. This study characterized PVLN identified after radical cystectomy (RC) and analyzed their impact on recurrence and survival. We reviewed...
25,238,701
[ 0.236252, -0.392365, -0.3499696, -0.4112467, 0.04516769, -0.2379628, 0.06224943, 0.07888653, -0.021146, 0.1419785, 0.04978257, 0.3962879, 0.1177247, -0.05392797, 0.008468689, -0.4426712, -0.008822088, 0.4080479, 0.3960774, 0.02335397, -0.05154763, 0.3711455, -0.139888, ...
Prognostic impact of WT1 expression prior to hematopoietic stem cell transplantation in children with malignant hematological diseases.
Malignant hematological diseases represent the most common pediatric cancer. As they cannot always be cured by chemotherapy alone, leukemia and myelodysplastic syndrome (MDS) are frequent medical indications for hematopoietic stem cell transplantation, yet even this treatment is not capable of preventing relapse for ce...
25,238,704
[ -0.04602468, -0.05082346, -0.1605971, -0.4784591, 0.07096856, -0.3599437, 0.005143734, 0.152653, -0.06995231, 0.09004986, 0.2573994, 0.3595647, -0.00493361, -0.2416099, -0.3445924, -0.02216373, -0.07146923, 0.2369299, -0.1689777, -0.01030966, 0.4273711, -0.2625807, -0.183...
Photochemistry of nucleic acid bases and their thio- and aza-analogues in solution.
The steady-state and time-resolved photochemistry of the natural nucleic acid bases and their sulfur- and nitrogen-substituted analogues in solution is reviewed. Emphasis is given to the experimental studies performed over the last 3-5 years that showcase topical areas of scientific inquiry and those that require furth...
25,238,718
[ -0.2186342, -0.1699829, -0.1874909, -0.03602141, 0.1996796, -0.129444, -0.2125098, -0.1618369, 0.4035457, -0.08399055, 0.05104126, -0.04765076, 0.2468068, -0.105875, -0.4097656, 0.02744395, -0.3677127, -0.09013192, -0.1413042, 0.09747094, 0.6963266, 0.08889086, -0.3993047...
γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type.
Native γ-aminobutyric acid (GABA)A receptors consisting of α4, β1-3, and δ subunits mediate responses to the low, tonic concentration of GABA present in the extracellular milieu. Previous studies on heterologously expressed α4βδ receptors have shown a large degree of variability in functional properties, including sens...
25,238,745
[ 0.3409127, -0.2279644, -0.4315068, 0.1300282, 0.1452343, -0.3945311, -0.1521681, 0.20977, 0.1353429, 0.1207723, 0.252126, 0.2404325, 0.06859495, 0.0278949, -0.1054209, 0.01443796, -0.8353159, 0.03244311, 0.05664445, 0.1990021, 0.4278103, 0.4667651, -0.1060466, 0.3268926...
Phenylcoumaran benzylic ether reductase prevents accumulation of compounds formed under oxidative conditions in poplar xylem.
Phenylcoumaran benzylic ether reductase (PCBER) is one of the most abundant proteins in poplar (Populus spp) xylem, but its biological role has remained obscure. In this work, metabolite profiling of transgenic poplar trees downregulated in PCBER revealed both the in vivo substrate and product of PCBER. Based on mass s...
25,238,751
[ 0.1669228, 0.2923392, 0.1007349, 0.1907097, 0.0001929354, 0.1208111, -0.2040659, 0.01815859, 0.04912261, 0.05165813, 0.1629448, -0.008033943, -0.1965825, -0.2936059, -0.5753042, 0.1636124, -0.2186199, 0.4300294, 0.2233848, 0.2787879, 0.09229506, 0.2612361, -0.06663812, ...
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Differentiation of B cells into Ab-secreting cells induces changes in gene transcription, IgH RNA processing, the unfolded protein response (UPR), and cell architecture. The transcription elongation factor eleven nineteen lysine-rich leukemia gene (ELL2) stimulates the processing of the secreted form of the IgH mRNA fr...
25,238,757
[ 0.2695111, -0.3548694, -0.274279, -0.1901335, -0.1694399, -0.1504976, 0.4957989, 0.2961761, -0.05721115, 0.5695665, 0.0593252, 0.3945466, 0.3747333, -0.009455072, -0.6996881, 0.1325274, -0.1353665, -0.1986707, -0.06862336, -0.2418097, 0.7984753, -0.1626362, -0.0624029, ...
Myosin II does not contribute to wound repair in Dictyostelium cells.
Cells are always subjected to mechanical stresses, resulting in wounds of the cell membrane, but cells are able to repair and reseal their wounded membrane. Previous reports have shown that actin and myosin II accumulate around the wound and that the constriction of this purse-string closes the membrane pore. Here, we ...
25,238,760
[ -0.06994842, -0.4549208, -0.1358779, -0.06013861, -0.1755597, -0.016087, 0.006356873, 0.1783877, 0.3647906, 0.1517515, 0.04178132, -0.1524167, -0.3182058, -0.02183616, -0.577426, -0.002245998, -0.5141522, 0.103013, -0.04364958, 0.01555791, 0.8625828, 0.02033135, -0.067844...
Granulosicoccus marinus sp. nov., isolated from Antarctic seawater, and emended description of the genus Granulosicoccus.
A Gram-staining-negative, motile by flagella, non-pigmented, poly-β-hydroxybutyrate-producing, strictly aerobic and sphere-shaped bacterium, IMCC3490(T), was isolated from a coastal seawater sample from the Antarctic Peninsula. Optimal growth of strain IMCC3490(T) was observed at 20 °C, pH 8.0 and in the presence of 2 ...
25,238,763
[ -0.1818615, 0.2939074, 0.07939298, -0.3397714, -0.03248236, -0.04804909, -0.006717876, -0.06572128, 0.2133585, -0.1913223, -0.1217189, -0.07954121, -0.1002225, 0.2156516, -0.2395371, 0.01497459, -0.2577685, 0.566359, -0.3089078, 0.4309752, 0.31838, 0.09830293, 0.2541299, ...
Exogenous estrogen as mediator of racial differences in bioactive insulin-like growth factor-I levels among postmenopausal women.
The role of exogenous estrogen use in racial differences in insulin-like growth factor-I (IGF-I) levels which affect cancer risk is unclear. We investigated whether the relationship between race and circulating bioactive IGF-I proteins was mediated by exogenous estrogen and the extent to which exogenous estrogen influe...
25,238,773
[ -0.2336362, -0.1500637, -0.3429533, -0.2936523, 0.3522293, -0.1712453, -0.05759964, 0.3800006, 0.3947147, 0.0138761, -0.1324305, 0.106571, -0.02180238, -0.4018128, -0.2556482, -0.2039739, -0.1698792, 0.1001705, 0.04495813, -0.0469225, 0.02227261, 0.2797039, -0.1010434, ...
Developing a viva exam to assess clinical reasoning in pre-registration osteopathy students.
Clinical reasoning (CR) is a core capability for health practitioners. Assessing CR requires a suite of tools to encompass a wide scope of contexts and cognitive abilities. The aim of this project was to develop an oral examination and grading rubric for the assessment of CR in osteopathy, trial it with senior students...
25,238,784
[ 0.07613677, 0.01071856, 0.3380972, -0.06869776, 0.00006164729, -0.09964105, -0.1316491, -0.200842, -0.1308557, 0.02854179, 0.1585099, -0.06058742, -0.06641994, -0.2730225, -0.7977384, 0.01822149, -0.3966475, 0.1236238, -0.2131159, -0.03550032, 0.2040268, 0.4418014, -0.074...
Replication initiation and genome instability: a crossroads for DNA and RNA synthesis.
Nuclear DNA replication requires the concerted action of hundreds of proteins to efficiently unwind and duplicate the entire genome while also retaining epigenetic regulatory information. Initiation of DNA replication is tightly regulated, rapidly firing thousands of origins once the conditions to promote rapid and fai...
25,238,783
[ -0.03703341, 0.001151478, -0.005057733, -0.1754109, 0.02601178, -0.1708528, -0.1043726, 0.08856693, 0.38892, 0.2691759, 0.08048005, -0.1404975, -0.249993, 0.1399958, -0.4602457, -0.001980331, -0.2471701, -0.004085559, -0.2089695, -0.06482469, 0.2513764, 0.01765828, -0.478...
Oral corticosteroid use for clinical and cost-effective symptom relief of sore throat: study protocol for a randomized controlled trial.
Management of acute sore throat poses a significant burden on UK general practices, with almost 10% of registered patients attending their GP with sore throat every year. Nearly half of all patients presenting with acute sore throat are treated with antibiotics, despite their limited effect. In a recent systematic revi...
25,238,785
[ -0.1646653, -0.09441712, -0.07088595, -0.03093728, -0.2297703, -0.06583684, -0.1398455, -0.1696051, 0.1234245, -0.1693643, -0.141604, 0.08461651, -0.02939739, -0.03865992, -0.1203941, -0.1396113, 0.01172584, 0.03993215, -0.2410844, 0.1928363, -0.01191879, 0.07974786, -0.0...
Cetyltrimethylammonium bromide capped 9-anthraldehyde nanoparticles for selective recognition of phosphate anion in aqueous solution based on fluorescence quenching and application for analysis of chloroquine.
Cetyltrimethylammonium bromide (CTAB) capped 9-Anthraldehyde nanoparticles (9-AANPs) in aqueous suspension prepared by reprecipitation method are seen brick shaped in Scanning Electron Microscope image. The Dynamic Light Scattering histogram of nanoparticle suspension reveals narrow particle size distribution and avera...
25,238,801
[ -0.07257225, 0.1215998, -0.1203886, -0.04836188, -0.1387588, -0.0455001, -0.4089744, 0.1576633, 0.4497262, -0.2109373, -0.1406479, 0.2310246, 0.003775491, 0.2905891, -0.36981, 0.02248277, -0.6422627, 0.08106639, 0.1635323, 0.2062222, 0.1485627, 0.3480121, -0.1047316, -0...
[Safety assessment of stevia rebaudiana bertoni grown in southeastern Mexico as food sweetener].
Stevia rebaudiana leaves and their glycosides have been recently and significantly used so important as sweeteners. However, it has been reported an antihyperglycemic effect of the extract and a glycoside. The aim of this study was to quantify S. rebaudiana glycosides, assess cytotoxicity of the extract and its acute a...
25,238,836
[ -0.2890683, -0.1796037, -0.208353, -0.01420102, 0.3232993, 0.08776316, -0.1561409, 0.07247037, 0.4794697, -0.5413272, 0.01952659, -0.2371541, -0.2571051, -0.4048675, -0.6113505, -0.2533555, -0.3159355, 0.2394763, 0.3560655, 0.2156672, -0.07541612, 0.1888751, 0.05577203, ...
A genetic variant of the CAPN10 gene in Mexican subjects with dyslipidemia is associated with increased HDL-cholesterol concentrations after the consumption of a soy protein and soluble fiber dietary portfolio.
Dyslipidemia is a major public health problem, and therefore, it is important to develop dietary strategies to diminish the prevalence of this disorder. It was recently reported that diet may play an important role in triggering insulin resistance by interacting with genetic variants at the CAPN10 gene locus in patient...
25,238,846
[ 0.1583273, -0.1180439, 0.3995722, 0.08055726, -0.2595609, 0.05777091, 0.02940202, -0.04416098, 0.457184, -0.04865387, 0.1407212, -0.1615009, -0.2399513, -0.3658359, -0.3581389, -0.4688761, -0.4647057, -0.05989281, 0.0955599, -0.01626798, -0.3743661, 0.3495978, 0.1266627, ...
[About a very extreme malnutrition case in a female patient with long-term non-treated restrictive anorexia nervosa].
Anorexia nervosa is an eating disorder that often causes malnutrition and carries high mortality risk. A multidisciplinary and highly experienced team is needed to succeed in nutrition education and avoid the refeeding syndrome. We report the most severe case of malnutrition secondary to anorexia nervosa treated in our...
25,238,849
[ -0.2823744, -0.04095507, 0.1349558, -0.1222532, 0.1890701, -0.2819814, -0.186884, -0.2965404, -0.1533474, 0.02782756, 0.1405388, 0.3611951, -0.160042, 0.05333814, -0.3752634, -0.16889, -0.1961678, 0.2314482, -0.1175697, 0.03691959, -0.07969092, 0.2022827, -0.06116891, 0...
Reducing excess stiffness in Stiff Person Syndrome using CBT: A case study.
Stiff Person Syndrome (SPS) is a rare neurological condition, characterised by rigidity in the trunk and limbs. Comorbid anxiety is common and known to exacerbate stiffness. This case study examines the extent to which psychological treatment of comorbid anxiety alleviated stiffness in a patient whose condition was exa...
25,238,861
[ -0.1733295, 0.2176868, -0.02341595, -0.09199668, -0.05171328, -0.2093443, -0.1982017, -0.07627872, 0.2103643, -0.1504001, 0.1436882, 0.1067003, -0.08741144, -0.2100773, 0.1536448, 0.1787787, -0.7244798, -0.01939771, -0.3306198, 0.1373575, -0.4486839, 0.2317992, -0.1183677...
Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.
Fatigue is a major cause of disability and handicap in Multiple Sclerosis (MS) patients. The management of this common problem is often difficult. Chronic Fatigue Syndrome (CFS/ME) is another common cause of fatigue which is prevalent in the same population of middle aged females commonly affected by MS. This report ai...
25,238,862
[ -0.08076309, 0.0801255, 0.3231468, -0.1734449, -0.05089771, -0.260775, -0.131283, 0.08625226, -0.3660673, -0.1492316, 0.06880011, 0.07271256, 0.1725058, -0.1093828, -0.3015174, -0.2793846, -0.1210238, 0.06627024, 0.009771588, -0.1821275, -0.3638839, -0.07754035, -0.163623...
Identification of microRNA-93 as a functional dysregulated miRNA in triple-negative breast cancer.
MicroRNAs (miRNAs) are widely recognized as key players in cancer progression and drug resistance, but less is known about the role of miRNAs in triple-negative (estrogen receptor, progesterone receptor, and HER-2/neu) breast cancer (TNBC). The aim of the present study was to examine the expression profile of miRNAs an...
25,238,878
[ -0.07226191, 0.1038564, 0.3812325, -0.1834522, -0.1350044, -0.003154772, -0.2708426, 0.3691242, 0.4004993, 0.3294797, 0.2472119, 0.09789556, -0.1321996, -0.06968544, -0.2632398, -0.2017463, 0.2026887, 0.02961976, -0.2375597, -0.119417, 0.1566296, 0.08661557, -0.01831273, ...
Long-term outcomes of septal reduction for obstructive hypertrophic cardiomyopathy.
Surgical myectomy and alcohol septal ablation (ASA) aim to decrease left ventricular outflow tract (LVOT) gradient in hypertrophic cardiomyopathy (HCM). Outcome of myectomy beyond 10 years has rarely been described. We describe 20 years of follow-up of surgical myectomy and 5 years of follow-up for ASA performed for ob...
25,238,885
[ 0.06481482, 0.1507323, -0.1633161, -0.3784651, -0.1282048, -0.1719533, 0.1526976, -0.1674443, 0.01167885, -0.3809071, -0.2228916, 0.2772712, 0.2141068, -0.3632032, -0.2971455, -0.0004583832, -0.158941, 0.1489941, 0.2122882, -0.005667119, 0.1302858, 0.331008, -0.1619603, ...
Progress towards the integration of pharmacogenomics in practice.
Understanding the role genes and genetic variants play in clinical treatment response continues to be an active area of research with the goal of common clinical use. This goal has developed into today's industry of pharmacogenomics, where new drug-gene relationships are discovered and further characterized, published ...
25,238,897
[ -0.1307248, -0.1492115, -0.1026052, -0.4252793, 0.02574646, -0.08818214, 0.2621398, 0.144314, 0.1166231, -0.08998774, 0.1604807, 0.07711975, -0.08303623, -0.3083324, -0.6535608, -0.05803101, -0.1459183, 0.2750222, -0.01369817, 0.2754558, -0.1391607, 0.2013095, -0.3810067,...
A new minimally invasive treatment for anal fistula.
In colorectal surgery, eradicating the fistula and maintaining continence are still complex challenges for a colorectal surgeon. A minimally invasive method using a novel device was performed to consecutively treat 14 patients with anal fistula from August 2008 to November 2009. After a follow-up period of 36 months, 1...
25,238,933
[ -0.09242738, 0.1714394, -0.07541069, -0.03679677, -0.1193914, -0.1942372, -0.1209166, -0.2302214, 0.1289112, -0.07965683, 0.2094008, -0.1646687, 0.1478112, -0.1496972, -0.2257176, -0.3127075, -0.3568225, -0.155771, -0.1354517, -0.4419434, -0.1373077, 0.2734893, 0.1065419,...
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities.
A 55-year-old female with T-cell large granular lymphocytic leukemia (T-LGL) (CD8+) was initially treated with anti-thymocyte globulin and then cyclosporine due to anemia/neutropenia. While the severity of cytopenia varied with the therapy, the T-LGL persisted. Eight years after the initial diagnosis, she developed lym...
25,238,936
[ 0.1856781, 0.06265341, 0.0714421, -0.1678195, -0.05987686, -0.2604247, 0.1441618, -0.0639687, 0.002274398, 0.2196283, -0.1405084, 0.2843417, -0.1663679, 0.3093314, -0.2437075, 0.0798915, -0.2910145, 0.1238258, 0.1245374, -0.01440614, 0.1985491, 0.1423981, -0.02869203, -...
Recurrence of lung adenocarcinoma after an interval of 15 years revealed by demonstration of the same type of EML4-ALK fusion gene.
We carried out an experiment on a 58-year-old man with multiple left lung tumors and swelling of multiple lymph nodes. For clinical staging and therapeutic purposes, bronchoalveolar lavage (BAL) cytology and lung biopsy were performed. The biopsy specimen revealed the left lower lung mass to be immunohistochemically AL...
25,238,939
[ -0.02336851, -0.1857781, -0.2004949, -0.3077997, -0.03111305, -0.2969292, -0.1121134, -0.08066535, -0.09618468, 0.04208792, 0.1301109, 0.3411046, -0.04074404, 0.05582054, 0.1445844, 0.05792978, -0.3188707, 0.3008626, -0.1122519, 0.2231976, 0.08793631, 0.1759772, -0.115013...
Admixture Indicative Interval (AII): a new approach to assess trends in genetic admixture.
The genetic admixture is a dynamic and diachronic process, taking place during a great number of generations. Consequently, a sole admixture rate does not represent such an event and several estimates could help to take into account its dynamics. We developed an Admixture Indicative Interval (AII) which gives a mathema...
25,238,944
[ -0.2560149, -0.3037002, 0.2317786, -0.05047413, 0.108253, -0.403663, -0.2128252, 0.1067422, 0.1599825, -0.1324165, -0.3111174, 0.1285881, -0.0007756904, -0.500282, -0.2003212, -0.2270455, -0.332533, 0.02144421, -0.3373365, 0.2500872, 0.1065168, 0.1468391, 0.049619, 0.17...
Phylogenetic position of the bee genera Ancyla and Tarsalia (Hymenoptera: Apidae): a remarkable base compositional bias and an early Paleogene geodispersal from North America to the Old World.
We address the phylogenetic position of the bee genera Tarsalia and Ancyla (currently forming the tribe Ancylaini) on the basis of morphological, molecular and combined data. We assembled a matrix of 309 morphological characters and 5246 aligned nucleotide positions from six nuclear genes (28S, EF-1a, wingless, POL2, L...
25,238,948
[ 0.180247, 0.03297703, -0.1420927, -0.1715469, -0.1113958, -0.2649965, 0.003979533, -0.3050529, 0.1651132, -0.1431399, -0.05487716, -0.05504844, 0.01254214, 0.02591924, -0.6212238, -0.04663816, -0.1468472, 0.1830227, -0.2763825, 0.4467148, 0.2638507, 0.1657846, -0.1916071,...
Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging.
We established a ternary anionic complex constructed with polyamidoamine dendrimer (4th generation; G4) modified with chelating agents (diethylenetriamine pentaacetic acid (DTPA) derivative), polyethyleneimine (PEI), and γ-polyglutamic acid (PGA) as a safe nano-platform for molecular imaging. We prepared indium-111-lab...
25,238,958
[ 0.1625636, 0.07516776, -0.2251843, 0.3547734, 0.1551784, -0.1095254, -0.1450356, -0.2192606, 0.03812518, 0.2325125, -0.2053852, -0.01411071, 0.07041092, -0.191936, -0.4795728, -0.1935833, -0.6288567, -0.02425996, 0.4318223, -0.002878846, 0.2360153, 0.5199065, 0.1648432, ...
Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.
L-fucose, a monosaccharide widely distributed in eukaryotes and certain bacteria, is a determinant of many functional glycans that play central roles in numerous biological processes. The molecular mechanism, however, by which fucosylation mediates these processes remains largely elusive. To study how changes in fucosy...
25,238,963
[ -0.0735468, -0.04678572, -0.414515, -0.046725, 0.06045465, -0.3200998, -0.1298413, 0.3571667, -0.2419265, -0.1311597, -0.03986934, 0.2359532, -0.1983923, -0.2136061, -0.0669532, 0.01468736, -0.3664182, 0.0761079, -0.3047778, -0.2265952, 0.191899, 0.3921886, -0.1799231, ...
Fitness-to-practice concerns in rural undergraduate medical education: a qualitative study.
Since July 2010, new reporting requirements have applied to registered Australian health practitioners who have a reasonable belief that a practitioner or student (of any registered discipline) is exhibiting "notifiable conduct". A study of healthcare complaints reported that a small number of practitioners are over-re...
25,238,971
[ -0.09066001, 0.02547868, -0.1125769, -0.02170126, 0.3260273, -0.3408056, -0.216701, -0.1671124, -0.0726188, 0.1518087, 0.05259704, -0.1503998, 0.1028751, 0.0969359, -0.104842, -0.003032395, -0.3238125, -0.08269858, -0.4786873, 0.2312198, -0.2709821, 0.1370331, -0.00961165...
Evaluation of sixty-eight cases of fracture stabilisation by external hybrid fixation and a proposal for hybrid construct classification.
Hybrid external fixation (HEF) is an emerging technique for fracture stabilization in veterinary orthopedics, but its use has been reported in few papers in the veterinary literature. The linear and circular elements that form hybrid fixators can be connected in a very high number of combinations, and for this reason j...
25,238,972
[ -0.2091642, 0.4904382, 0.4288188, -0.3766494, -0.1692884, -0.4164376, 0.06835126, 0.03077255, 0.1797751, 0.3528693, 0.1195507, -0.4392021, -0.1244264, -0.3025218, -0.1523791, -0.1564706, -0.01299016, 0.1309233, 0.1215101, -0.4244793, 0.09052777, 0.1513833, -0.03125326, ...
Lessons for resource conservation from two contrasting small-scale fisheries.
Small-scale fisheries present challenges to management due to fishers' dependency on resources and the adaptability of management systems. We compared social-ecological processes in the sea cucumber fisheries of Zanzibar and Mayotte, Western Indian Ocean, to better understand the reasons for resource conservation or co...
25,238,980
[ 0.1636372, 0.114178, 0.2351714, -0.2196499, -0.1060201, -0.3965788, -0.2302584, 0.2292606, 0.1886382, -0.2177309, -0.09601194, 0.125097, -0.09545178, -0.04082828, -0.1366802, -0.2737243, -0.2853926, 0.1048369, 0.103429, 0.1312546, -0.03192551, 0.1330835, -0.1043564, -0....
The role the Great Barrier Reef plays in resident wellbeing and implications for its management.
Improvements in human wellbeing are dependent on improving ecosystems. Such considerations are particularly pertinent for regions of high ecological, but also social and cultural importance that are facing rapid change. One such region is the Great Barrier Reef (GBR). Although the GBR has world heritage status for its ...
25,238,982
[ -0.08592529, 0.1390087, 0.1906711, -0.1711716, -0.1977098, 0.006877373, -0.1299766, 0.1525622, -0.003606019, -0.4748331, 0.1034213, -0.1425117, -0.2167538, -0.079738, -0.3546441, -0.03023816, -0.355916, 0.3464513, -0.09763741, -0.2039338, 0.01176155, 0.2974104, 0.03244654...
Regional changes in elastic fiber organization and transforming growth factor β signaling in aortas from a mouse model of marfan syndrome.
In Marfan Syndrome (MFS), development of thoracic aortic aneurysms (TAAs) is characterized by degeneration of the medial layer of the aorta, including fragmentation and loss of elastic fibers, phenotypic changes in the smooth muscle cells, and an increase in the active form of transforming growth factor-β (TGFβ), which...
25,238,995
[ -0.02154781, -0.0917804, -0.2322216, -0.05912454, -0.03452083, 0.01292469, 0.2407895, -0.0872971, 0.1323107, 0.1994266, 0.1893988, -0.01725397, -0.3439173, -0.06497446, -0.4724361, 0.1454326, -0.5370399, -0.1508185, -0.3205257, 0.1258262, 0.4049081, 0.2462178, -0.04658773...
Escalating chronic kidney diseases of multi-factorial origin in Sri Lanka: causes, solutions, and recommendations.
During the last two decades, Sri Lanka, located close to the equator, has experienced an escalating incidence of chronic kidney disease (CKD) of unknown aetiology (CKDue) in dry zonal areas. Similar incidences of unusual CKDs have been reported in the dry zonal, agricultural areas of several other equatorial countries....
25,239,006
[ -0.1558228, 0.07215574, 0.2157309, 0.2334824, -0.2457921, -0.2994561, -0.5152602, -0.01538664, 0.1056402, -0.08026117, 0.03798937, 0.2084142, 0.1598232, 0.3280903, -0.2360194, 0.002916009, -0.3116904, 0.1135136, -0.1062678, 0.2720576, -0.2431542, 0.2293937, -0.2074966, ...
What can volunteer co-providers contribute to health systems? The role of people living with HIV in the Thai paediatric HIV programme.
In Thailand people living with HIV (PLHIV) have played a major role in shaping policy and practice. They have acted as volunteer co-providers, although their potential in terms of paediatric service provision has seldom been explored from a health systems perspective. We describe the Thai paediatric HIV care system and...
25,239,008
[ -0.02498507, -0.06897651, -0.1703165, -0.1730076, 0.3642341, -0.2300416, -0.08244083, 0.07367168, -0.0287362, -0.0638468, 0.05058813, -0.05216128, -0.1126743, 0.4174062, -0.2774104, -0.4040662, -0.3260758, 0.2122993, -0.1244248, 0.07187265, -0.03540541, 0.3285982, -0.0755...
Detection of biofilm production and antibiotic resistance pattern in clinical isolates from indwelling medical devices.
Microbial biofilms pose great threat for patients requiring indwelling medical devices (IMDs) as it is difficult to remove them. It is, therefore, crucial to follow an appropriate method for the detection of biofilms. The present study focuses on detection of biofilm formation among the isolates from IMDs. We also aime...
25,239,012
[ 0.2694785, -0.1037206, 0.250149, 0.1619506, -0.04442551, -0.07314783, -0.1577379, 0.5227577, 0.1244381, -0.04104121, -0.04003403, -0.154468, -0.1274743, 0.06110898, -0.270344, -0.06109554, -0.415628, 0.2069163, -0.3603487, 0.08372822, 0.5629236, -0.04698453, 0.3250716, ...
Pain, delirium, and physical function in skilled nursing home patients with dementia.
Skilled nursing facilities (SNFs) are major sites of postacute care for patients with dementia. A recent Office of the Inspector General report indicated that outcomes in SNFs are suboptimal because of poor-quality treatment, including the failure to provide needed care. Pain is frequently unrecognized and untreated in...
25,239,018
[ 0.1163617, 0.4325221, 0.1634899, -0.1339178, -0.06353375, -0.2332202, -0.1086226, 0.1615282, -0.2285716, -0.2165307, -0.07937577, -0.3303038, -0.2920111, -0.2438503, 0.01157254, -0.1764743, -0.5519747, 0.3299861, 0.2656603, -0.01783265, -0.3381256, 0.1421435, -0.06780665,...
Arthroscopic tenodesis through positioning portals to treat proximal lesions of the biceps tendon.
Arthroscopic biceps tenodesis is a good choice for treating proximal lesions of the biceps tendon. However, there are few descriptions of the surgical approach. We introduce a technique for proximal biceps tenodesis using positioning portals and placing suture anchors. Our patients had a minimum of 12 months of follow-...
25,239,022
[ -0.02343441, 0.1623297, -0.2889111, -0.2120069, -0.1346304, -0.2512177, -0.2653329, 0.4577878, 0.01557701, -0.1066316, 0.1124778, -0.2725611, -0.1110377, -0.2831756, -0.1167632, -0.3190491, -0.1180857, 0.05346766, -0.05475312, 0.0118981, 0.1367939, 0.03307835, -0.04604094...
Transport cyclists and road rules: what influences the decisions they make?
To determine the level of adherence by transport cyclists to road rules in traffic situations and their reasons for non-adherence. The Safer Cycling Study was a prospective cohort study of transport and recreational cyclists. Over 2000 cyclists were recruited between March and November 2011. 770 Transport cyclists aged...
25,239,024
[ -0.1598525, 0.2315585, -0.1538004, 0.1680616, 0.1089161, -0.2360027, -0.3161131, -0.2886147, 0.05014974, -0.1613532, 0.1098369, -0.3443869, 0.3060375, 0.1030669, 0.1631111, 0.02738978, -0.7052815, 0.2199574, -0.2621315, -0.2948791, -0.1750547, 0.2783912, -0.2054275, 0.0...
Synergic effects of ultrasound and laser on the pain relief in women with hand osteoarthritis.
Patients with pain avoid movements, leading to a gradual impairment of their physical condition and functionality. In this context, the use of ultrasound (US) and low-level laser therapy (LLLT) show promising results for nonpharmacological and noninvasive treatment. The aim of this study was evaluated the synergistic e...
25,239,030
[ 0.05269206, 0.3967208, 0.3299307, -0.003021434, -0.1246535, -0.4520434, 0.1272544, -0.05500727, 0.4385892, -0.1555213, -0.2631043, -0.2516405, -0.05840554, -0.4595915, -0.4580669, -0.1297944, -0.333039, -0.05178675, -0.3991631, -0.09498458, -0.2160312, -0.1129605, -0.0559...
Enhancement in production of recombinant two-chain Insulin Glargine by over-expression of Kex2 protease in Pichia pastoris.
Glargine is an analog of Insulin currently being produced by recombinant DNA technology using two different hosts namely Escherichia coli and Pichia pastoris. Production from E. coli involves the steps of extraction of inclusion bodies by cell lysis, refolding, proteolytic cleavage and purification. In P. pastoris, a s...
25,239,036
[ -0.003973631, 0.01509545, -0.2463977, -0.01176886, 0.2411454, 0.2349556, -0.05091932, 0.1189696, 0.1730796, 0.203033, 0.03620148, -0.4764682, -0.03657667, 0.02136187, -0.161106, 0.2464459, -0.2435966, -0.2221032, 0.3750875, -0.03414289, 0.3897181, 0.1636882, -0.05765805, ...
Neuropsychological heterogeneity in preschool ADHD: investigating the interplay between cognitive, affective and motivation-based forms of regulation.
There is a trend toward diagnosing ADHD prior to school entry. Despite this, there is a lack of studies investigating ADHD in the preschool years, at least studies including a large range of different neuropsychological functions. Our knowledge of the independent effects of different neuropsychological functions in rel...
25,239,053
[ -0.1608633, 0.471983, -0.1022531, -0.08853181, 0.2811009, -0.5372949, -0.2856104, 0.1499186, -0.231401, 0.1859465, 0.1633134, 0.311595, -0.09487656, -0.3632099, -0.7490985, 0.02021427, 0.1119899, 0.2417593, 0.040129, 0.1082054, 0.2637006, 0.204912, -0.02796141, -0.24744...
Remote quantitative analysis of minerals based on multispectral line-calibrated laser-induced breakdown spectroscopy (LIBS).
Laser-induced breakdown spectroscopy (LIBS) is a feasible remote sensing technique used for mineral analysis in some unapproachable places where in situ probing is needed, such as analysis of radioactive elements in a nuclear leak or the detection of elemental compositions and contents of minerals on planetary and luna...
25,239,065
[ 0.1820267, -0.05073011, 0.3374269, -0.1278817, -0.159453, -0.09135794, -0.4038496, -0.0557071, 0.3994605, 0.1398991, -0.005454672, -0.1580892, 0.05587281, -0.07799356, -0.7530387, 0.01157352, -0.2941156, 0.1170306, 0.005540551, -0.216696, 0.3504518, 0.05241824, -0.135531,...
Usefulness of chest CT scan for head and neck cancer.
Chest computed tomography (CT) is not performed routinely or worldwide as the initial diagnostic procedure for patients with head and neck cancer (HNC). The significance of the chest CT scan for HNC diagnosis has not been thoroughly defined. The present study reports findings in an effort to broaden the acceptance and ...
25,239,083
[ -0.07508337, -0.1084272, -0.06499517, -0.5636381, 0.01015192, -0.361026, -0.1180836, 0.1006266, 0.08052551, 0.2295044, -0.1000464, -0.07741537, -0.1060999, -0.2718222, -0.2531109, -0.6252791, -0.09786352, 0.1907266, 0.3751552, -0.100878, 0.05014149, 0.2529491, -0.2662272,...
Innate and adaptive immune responses of snatch-farrowed porcine-colostrum-deprived pigs to Mycoplasma hyopneumoniae vaccination.
The snatch-farrowed porcine-colostrum-deprived (SF-pCD) pig model, in which neonates are raised on commercially available bovine colostrum, is an alternative model for porcine infectious disease research. It is not known if SF-pCD pigs possess growth performance and immunity comparable to conventional, farm-raised pigs...
25,239,088
[ -0.1316891, -0.5230448, -0.07181927, -0.05245984, 0.01045714, -0.257377, -0.4066469, 0.09763451, -0.2133651, -0.4777632, 0.3346959, -0.08687366, 0.1243719, -0.2498338, -0.4028068, -0.1645892, -0.8022598, -0.04714135, -0.4953369, 0.2612219, 0.2716675, 0.04126015, 0.0613166...
Hierarchical acquisition of visual specificity in spatial contextual cueing.
Spatial contextual cueing refers to visual search performance's being improved when invariant associations between target locations and distractor spatial configurations are learned incidentally. Using the instance theory of automatization and the reverse hierarchy theory of visual perceptual learning, this study explo...
25,239,095
[ -0.190842, 0.2786976, -0.2869428, 0.1144076, 0.4047818, -0.3017846, -0.4838312, 0.1014845, 0.1545044, -0.01429128, 0.1458623, 0.007883894, 0.02950334, -0.1066299, -0.2435471, 0.2066796, -0.7869061, 0.01387404, -0.1909758, -0.382211, -0.1496797, 0.3418762, -0.2244667, 0....