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The role of exercise in reducing the risks of gestational diabetes mellitus in obese women.
The global obesity epidemic continues unabated, now rapidly expanding to developing countries. Multiple comorbidities and premature mortality are associated with obesity, most frequently diabetes. The associated financial and economical burden is escalating as well. The sedentary lifestyle adopted by many pregnant wome...
25,240,421
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Lessons from the atomic bomb about secondary MDS.
Myelodysplastic syndromes (MDSs) is a hematological neoplasm defined by ineffective hematopoiesis, dysplasia of hematopoietic cells, and risk of progression to acute leukemia. MDS occurs as de novo or secondary, and chemoradiotherapy for cancers is thought to increase the risk of MDS among patients. Recently, an epidem...
25,240,475
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Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity.
Quantitative studies of signal transduction systems have shown that ultrasensitive responses - switch-like, sigmoidal input/output relationships - are commonplace in cell signaling. Ultrasensitivity is important for various complex signaling systems, including signaling cascades, bistable switches, and oscillators. In ...
25,240,485
[ -0.1270456, -0.4237314, -0.04100217, -0.1368448, -0.01385425, -0.1949447, -0.1574208, 0.04184842, 0.354373, 0.1118818, 0.06855549, -0.1591927, 0.04812117, 0.2203599, -0.8491925, 0.03066439, -0.4852049, -0.03587862, -0.4275883, 0.001855623, 0.1774365, 0.1350651, 0.08827276...
Transcriptomic analysis of the myometrium during peri-implantation period and luteolysis--the study on the pig model.
In pigs, implantation begins with the attachment of embryos to the endometrium. As the process is regulated by the expression of numerous genes, endometrial transcriptomic profiles have been extensively studied in early gravid pigs. However, the myometrium, a secretory tissue, should not be neglected, as it can also pa...
25,240,502
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Social-, age- and gender differences in testing and positive rates for Chlamydia trachomatis urogenital infection - a register-based study.
Chlamydia trachomatis is suspected of causing female infertility. It is the most widespread sexually transmitted infection with an estimated general prevalence of ~5-10% with a peak in younger individuals. C. trachomatis infection is more prevalent among lower social classes. In this study, the association between age,...
25,240,514
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Cerebral embolic lesions detected with diffusion-weighted magnetic resonance imaging following carotid artery stenting: a meta-analysis of 8 studies comparing filter cerebral protection and proximal balloon occlusion.
The aim of this meta-analysis was to evaluate and compare the efficacy of the 2 different neuroprotection systems in preventing embolization during carotid artery stenting (CAS), as detected by diffusion-weighted magnetic resonance imaging (DW-MRI). Data from randomized and nonrandomized studies comparing both types of...
25,240,544
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Decline of compound muscle action potentials and statistical MUNEs during Wallerian degeneration.
In two previous studies, we found that the compound muscle action potential (CMAP) amplitude loss was significantly higher than the loss of estimated motor unit numbers in the course of Wallerian degeneration (WD). In order to overcome some drawbacks of the method previously used, we performed a similar CMAP vs MUNE co...
25,240,559
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Dual versus single antiplatelet therapy in patients undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis.
Although dual antiplatelet therapy (DAPT) with clopidogrel and aspirin is a widely accepted strategy in patients undergoing transcatheter aortic valve replacement (TAVR), this approach is not evidence based. We therefore sought to systematically review the current evidence for this practice in terms of 30-day outcome l...
25,240,570
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Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers.
α-Synuclein (aSyn) aggregation, mitochondrial dysfunction and oxidative damage has been shown to be related to the death of dopaminergic neurons in Parkinson's disease (PD). Prolyl oligopeptidase (PREP) is proposed to increase aSyn aggregation, and PREP inhibition has been shown to inhibit the aggregation process in vi...
25,240,592
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Migraine and nosebleed in children case series and literature review.
The presence of nose bleeding during a migraine attack as a single occurrence is so far rarely reported. Therefore, we have decided to report such occurrences we have noticed to further improve and build upon possible existing knowledge of such incidences. 728 children with an average age of 11.5 years, suffering from ...
25,240,603
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The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.
Histone deacetylase inhibitors (HDACi) pleiotropy is largely due to their nonselective inhibition of various cellular HDAC isoforms. Connecting inhibition of a specific isoform to biological responses and/or phenotypes is essential toward deconvoluting HDACi pleiotropy. The contribution of classes I and II HDACs to the...
25,240,614
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Safety of a nasal vaccine against Streptococcus pneumoniae using heat-killed Lactobacillus casei as adjuvant.
Streptococcus pneumoniae is a highly important respiratory pathogen that causes infections in children, elderly people and immunocompromised people around the world. Pneumococcal vaccines licensed did not reach to eradicate the pneumococcal infection. In a previous study was demonstrated the effectiveness of a nasal ex...
25,240,632
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Differences in lens optical plasticity in two gadoid fishes meeting in the Arctic.
Arctic and boreal/temperate species are likely to be evolutionary adapted to different light regimes. Currently, the boreal/temperate Atlantic cod (Gadus morhua) is coexisting with the native polar cod (Boreogadus saida) in the Arctic waters around Svalbard, Norway. Here, we studied light/dark adaptative optical plasti...
25,240,636
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Eating behaviour among undergraduate students. Comparing nutrition students with other courses.
Our main aim was to compare eating behaviour between Portuguese undergraduate nutrition students and students attending other courses. Several eating behaviour dimensions were compared between 154 nutrition students and 263 students from other areas. Emotional and external eating were assessed by the Dutch Eating Behav...
25,240,638
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Nerve blocks for chronic pain.
Nerve blocks are often performed as therapeutic or palliative interventions for pain relief. However, they are often performed for diagnostic or prognostic purposes. When considering nerve blocks for chronic pain, clinicians must always consider the indications, risks, benefits, and proper technique. Nerve blocks encom...
25,240,668
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Successful aging, dietary habits and health status of elderly individuals: a k-dimensional approach within the multi-national MEDIS study.
The definition and determinants of successful aging is still controversial. Although dietary habits have long been associated with aging, eating habits and behaviors have rarely been included in various proposed indices of successful aging. The aim of this work was to evaluate determinants of successful aging together ...
25,240,688
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Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials.
Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 (PCSK9) under investigation for treatment of hypercholesterolemia and reduction of cardiovascular events. The COMBO studies, part of the Phase 3 ODYSSEY clinical trial program, are designed to evaluate the efficacy and safe...
25,240,705
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Socio-cognitive influences on the domain-specificity of prosocial behavior in the second year.
The main aim of this study was to explain the domain-specificity of early prosocial behavior in different domains (i.e., helping, comforting, and cooperation) by simultaneously assessing specific socio-cognitive factors (i.e., self-other-differentiation and joint attentional skills) that were hypothesized to be differe...
25,240,709
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Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model.
We aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs of 0.05% oxymetazol...
25,240,710
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8-Hydroxy-2'-deoxyguanosine expression predicts outcome of esophageal cancer.
Esophageal cancer is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA. We analyzed the predictive value of 8-OHdG expression on postoperative survival of patients with esophageal cancer with univariate and mul...
25,240,715
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Activity-guided isolation, identification and quantification of biologically active isomeric compounds from folk medicinal plant Desmodium adscendens using high performance liquid chromatography with diode array detector, mass spectrometry and multidimentional nuclear magnetic resonance spectroscopy.
The antioxidant activity of the crude extract (60% ethanol) from the leaves of Desmodium adscendens (Sw.) DC. (Fabaceae) was observed in DPPH, xanthine/xanthine oxidase, lipid peroxydation and neutrophils burst tests. Further activity-guided fractionation on C18 column (water, 20% methanol, 50% methanol and 100% methan...
25,240,729
[ 0.1840629, 0.3178329, -0.04486489, 0.09127013, 0.03135001, -0.1697946, -0.1151741, 0.205744, 0.1535266, -0.3345222, -0.03836101, -0.454636, -0.0923752, -0.1299228, -0.4556712, 0.1370063, -0.5359943, 0.3502071, 0.1948469, 0.1797436, 0.06970045, 0.1996237, -0.3955066, -0....
The functional role of Cys3-Cys4 loop in hydrophobin HGFI.
Hydrophobins are a large group of low-molecular weight proteins. These proteins are highly surface-active and can form amphipathic membranes by self-assembling at hydrophobic-hydrophilic interfaces. Based on physical properties and hydropathy profiles, hydrophobins are divided into two classes. Upon the analysis of ami...
25,240,738
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Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.
Botulinum neurotoxins (BoNTs) are among the most poisonous biological substances known. They assemble with non-toxic non-hemagglutinin (NTNHA) protein to form the minimally functional progenitor toxin complexes (M-PTC), which protects BoNT in the gastrointestinal tract and releases it upon entry into the circulation. H...
25,240,768
[ -0.3378361, -0.1890791, -0.1245701, -0.1573413, 0.116308, -0.04721003, -0.1279595, 0.232011, 0.08601927, -0.02539156, 0.08664163, 0.06880478, -0.01960526, -0.1553999, -0.1869597, 0.1720633, -0.07021388, 0.1167269, 0.3042533, -0.1161627, 0.2507885, 0.07140476, -0.1468989, ...
Adding a "GRADE" to the quality appraisal of rheumatoid arthritis guidelines identifies limitations beyond AGREE-II.
To assess how well treatment recommendations for rheumatoid arthritis (RA) address Grading of Recommendations Assessment, Development and Evaluation (GRADE) steps and determine whether these steps can be adequately appraised using Appraisal of Guidelines Research & Evaluation II (AGREE-II). We systematically review...
25,240,769
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Ultraviolet B radiation-stimulated urocortin 1 is involved in tyrosinase-related protein 1 production in human melanoma HMV-II cells.
Ultraviolet B (UVB) radiation stimulates cutaneous melanin pigmentation. The melanosomal enzyme tyrosinase-related protein 1 (TRP1) is involved in the modulation of pigment production in response to this stressor. Recent molecular and biochemical analyses have revealed the presence of corticotropin-releasing factor (CR...
25,240,771
[ -0.001567248, -0.6768481, -0.223925, -0.3082679, 0.2717104, -0.4224424, -0.2919317, -0.1290465, 0.2272868, 0.1234812, 0.3099946, 0.05068504, 0.1437298, -0.1202103, -0.3844993, -0.001239357, 0.01599827, 0.09632156, 0.2561136, -0.1919328, 0.2478713, 0.1918594, -0.2859625, ...
Epigenetics of cancer stem cells: Pathways and therapeutics.
Epigenetic alterations including DNA methylation and histone modifications are the key factors in the differentiation of stem cells into different tissue subtypes. The generation of cancer stem cells (CSCs) in the process of carcinogenesis may also involve similar kind of epigenetic reprogramming where, in contrast, it...
25,240,776
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IL-10-overexpressing B cells regulate innate and adaptive immune responses.
Distinct human IL-10-producing B-cell subsets with immunoregulatory properties have been described. However, the broader spectrum of their direct cellular targets and suppressive mechanisms has not been extensively studied, particularly in relation to direct and indirect IL-10-mediated functions. The aim of the study w...
25,240,783
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Evolution and function of light harvesting proteins.
Photosynthetic eukaryotes exhibit very different light-harvesting proteins, but all contain membrane-intrinsic light-harvesting complexes (Lhcs), either as additional or sole antennae. Lhcs non-covalently bind chlorophyll a and in most cases another Chl, as well as very different carotenoids, depending on the taxon. Th...
25,240,794
[ 0.1409195, 0.009301421, -0.08872567, -0.09773254, 0.008811304, -0.2555562, -0.1300737, -0.02407163, 0.1986417, 0.3001189, 0.1428895, -0.08413238, -0.003054646, -0.1836281, -0.4639182, -0.2402054, -0.6106557, 0.006109544, 0.130389, -0.1067835, 0.1272731, 0.3174045, -0.3442...
Medical specialty-related adherence to anti-osteoporotic regimens in fragility hip fracture patients.
There is poor adherence in the management of osteoporotic fractures. We designed a study to investigate adherence to osteoporotic regimens among osteoporotic hip fracture patients and to analyze the risk factors associated with poor compliance. This retrospective chart-review study was carried out using a database of o...
25,240,801
[ -0.01291938, 0.05514797, -0.000414224, -0.02628517, -0.1201321, -0.04487927, -0.1666766, 0.07227698, 0.4200059, -0.2225664, 0.1970852, -0.1110197, -0.1123249, -0.2659256, -0.631834, 0.01950789, -0.23387, 0.3700871, 0.2101384, 0.007459374, -0.3339583, -0.1082785, -0.408676...
Post-transplant high-dose cyclophosphamide for the prevention of graft-versus-host disease.
Cyclophosphamide's lack of hematopoietic stem cell toxicity and its unique effects on the immune system have prompted several investigators to explore its potential for the prevention of graft-versus-host disease (GVHD). In haploidentical hematopoietic stem cell transplants, post-transplant cyclophosphamide together wi...
25,240,817
[ 0.01334951, -0.1204357, -0.1426842, -0.2540979, 0.1520184, 0.04868273, 0.07328749, 0.1606058, -0.1556141, 0.03288877, 0.02652584, 0.06969067, 0.08776227, 0.4266621, -0.335505, -0.4024572, -0.02938036, -0.01305433, -0.02171708, -0.1864353, -0.1292143, 0.2964786, -0.1441249...
Serum thymus and activation-regulated chemokine level monitoring may predict disease relapse detected by PET scan after reduced-intensity allogeneic stem cell transplantation in patients with Hodgkin lymphoma.
Patients with relapsed and refractory Hodgkin lymphoma (HL) may experience long-term survival after allogeneic stem cell transplantation (alloSCT), but disease recurrence represents the main cause of treatment failure. Positron-emission tomography (PET)-positive patients after alloSCT have a dismal outcome. Serum thymu...
25,240,818
[ 0.09058081, -0.2163114, -0.2448799, -0.5748709, 0.07067887, -0.3872333, -0.1345479, 0.1135115, -0.1004041, 0.2687187, 0.06005005, -0.1942851, 0.02349218, 0.0812061, -0.02210192, 0.03085563, -0.1523091, 0.05665326, 0.08330979, 0.1008572, -0.1336991, 0.3045355, -0.1460995, ...
The evolving field of kinase inhibitors in thyroid cancer.
Most of the genetic events implicated in the pathogenesis of thyroid cancer (TC) involve genes with kinase activity. Thus, kinase inhibitors (KIs) are very relevant in this field. KIs are considered the most suitable treatment for patients with iodine-refractory differentiated TC; these patients comprise the subgroup w...
25,240,824
[ -0.1911899, -0.1207646, 0.2370949, -0.5674556, -0.09349082, -0.4042807, 0.1823652, -0.1030285, 0.04503552, 0.2159896, 0.1890906, 0.1547996, -0.2962622, -0.1240259, -0.2110123, -0.4882865, -0.2858526, 0.1542639, 0.2380032, 0.1086458, 0.1061783, 0.2947353, -0.2895572, 0.2...
Structural, optical, mechanical and dielectric studies of pure and doped L-Prolinium trichloroacetate single crystals.
In the present work, pure and metal substituted L-Prolinium trichloroacetate (LPTCA) single crystals were grown by slow evaporation method. The grown crystals were subjected to single crystal X-ray diffraction (XRD), powder X-ray diffraction, FTIR, UV-Visible-NIR, hardness, photoluminescence and dielectric studies. The...
25,240,832
[ 0.05135067, -0.1609392, 0.1623386, -0.006162339, -0.2164496, -0.3863761, -0.2547646, -0.005283746, 0.04858592, 0.2564231, 0.01640451, 0.3820377, -0.003150979, 0.0684484, -0.3933738, -0.05957144, -0.1508312, 0.07580399, -0.5150398, 0.338283, -0.01133491, 0.2268879, -0.1425...
Pathophysiology of the hepoxilins.
There is increasing evidence from various scientific groups that hepoxilins represent novel inflammatory mediators. In vitro studies have shown that the hepoxilins cause mobilization of intracellular calcium in human neutrophils, cause plasma leakage, and potently stimulate chemotaxis of human neutrophils. In vivo, the...
25,240,838
[ 0.1427438, -0.301975, -0.3105758, -0.3631451, -0.00009327353, -0.108464, 0.003592667, 0.2573224, 0.02414458, -0.06011828, 0.1010084, -0.3603108, -0.1235527, -0.3859703, -0.2807935, 0.151052, 0.1655727, 0.1009927, 0.05907214, 0.2965437, -0.3006824, 0.6176285, -0.0497125, ...
The association of suicide-related Twitter use with suicidal behaviour: a cross-sectional study of young internet users in Japan.
Infodemiology studies for suicide prevention have become increasingly common in recent years. However, the association between Twitter use and suicide has only been partially clarified. This study examined the association between suicide-related tweets and suicidal behaviour to identify suicidal young people on the Int...
25,240,843
[ -0.2234024, 0.08784185, 0.3132763, -0.1269069, 0.4367233, -0.225399, -0.2734064, -0.2295075, 0.1513485, -0.4566563, 0.2771666, -0.0976333, 0.05142036, 0.3699769, -0.5211472, -0.03785761, -0.2436524, 0.4980771, 0.2556368, -0.1514154, 0.1989764, 0.5264123, -0.2285402, 0.1...
Water treatment of hexavalent chromium by gelatin-impregnated-yeast (Gel-Yst) biosorbent.
A method is described for biosorption and water treatment of Cr(VI) from aqueous and real water samples by using gelatin-impregnated-yeast as a novel biosorbent. Gelatin and yeast materials (Gel-Yst) were combined together to form a novel eco-friendly, non-toxic, non-carcinogenetic, biodegradable, biocompatible and ine...
25,240,854
[ -0.1634398, -0.0130443, 0.1848591, -0.0944619, 0.1773211, -0.2712098, -0.3119127, -0.1380569, 0.07629592, 0.2086232, -0.002627334, 0.245435, -0.2196759, 0.187344, -0.4744734, 0.05275242, 0.01916493, 0.2340408, 0.03490395, -0.3262732, 0.1000079, 0.0721768, -0.05846445, -...
[Pliability and deflection of diagnostic catheters].
The cardiac catheter is an intravascular catheter, which is introduced or implanted into the heart for diagnostic or therapeutic reasons. The catheters may break or king during their introduction and/or removal. The aim of the authors was to study the pliability of two catheters with the same material but different dia...
25,240,876
[ -0.01621928, 0.01184987, 0.03355262, -0.08051024, 0.07158601, -0.07888688, 0.1467706, 0.2721978, 0.101002, 0.268659, 0.221417, -0.101581, -0.06674992, -0.2441782, -0.1067911, -0.4393071, -0.7267613, 0.3075036, 0.03679703, 0.08822329, 0.4434126, -0.1068774, 0.06873743, 0...
A biochemical approach to identify direct microRNA targets.
We have recently developed a biochemical approach to isolate miRNA-bound mRNAs and have used this method to identify the genome-wide mRNAs regulated by the tumor suppressor miRNA miR-34a. This method involves transfection of cells with biotinylated miRNA mimics, streptavidin pulldown, RNA isolation, and qRT-PCR. The pr...
25,240,884
[ -0.09751673, -0.07741054, -0.01447587, -0.185184, -0.08210533, -0.2483301, -0.2867807, 0.3093155, 0.2393937, -0.05492648, 0.1722027, 0.1569888, 0.09731875, -0.05173117, -0.4805654, 0.2585859, -0.3184388, 0.06006493, -0.07593108, 0.1612323, 0.3374417, 0.1133856, -0.1913358...
Identification and validation of miRNA target sites within nontraditional miRNA targets.
miRNAs are endogenous small RNAs that regulate gene expression through recognition of complementary RNA sequences. While miRNAs have generally been understood to repress gene expression posttranscriptionally through recognition of 3'-untranslated regions (3'-UTRs) of mRNA transcripts, they have the potential to target ...
25,240,886
[ -0.1729457, 0.1863715, 0.004546305, -0.1621895, 0.05450945, -0.1687619, -0.1770676, 0.142124, 0.2999026, -0.1560799, 0.1376033, -0.0887117, 0.2149735, -0.08849082, -0.5797944, 0.03905163, -0.2136694, 0.12936, -0.003747297, -0.07704619, 0.1641541, 0.1223826, -0.1540683, ...
A new microcolumn-type microchip for examining the expression of chimeric fusion genes using a nucleic acid sandwich hybridization technique.
We report a new type of microcolumn installed in a microchip. The architecture allows use of a nucleic acid sandwich hybridization technique to detect a messenger RNA (mRNA) chain as a target. Data are presented that demonstrate that the expression of a chimeric fusion gene can be detected. The microcolumn was filled w...
25,240,923
[ -0.1303103, 0.3380206, -0.08711387, -0.101451, 0.1038404, -0.2628884, -0.4041986, 0.1929224, 0.242486, 0.05596957, 0.0802656, -0.2314492, 0.2057947, 0.1207626, -0.5291594, -0.102848, -0.3228553, -0.1828264, -0.1376914, 0.05010336, 0.5653465, -0.1608532, 0.08140279, 0.28...
Lehr's fields of campaniform sensilla in beetles (Coleoptera): functional morphology. I. General part and allometry.
In this first of three articles we show the construction of the articular part of the elytron, the root. The root bears a conspicuous field of campaniform sensilla. This field was studied using light and scanning electron microscopes. The diversity of shape of the field among beetles, types of orientation of elongated ...
25,240,964
[ 0.270064, -0.1337836, 0.1360019, 0.1020999, 0.1358131, -0.3580939, -0.1443929, -0.03492222, 0.2361328, 0.1175799, -0.0697615, -0.4757923, 0.05288969, -0.2819475, -0.3518253, 0.06347339, -0.4984998, 0.2873548, -0.07179172, 0.1355124, 0.40198, 0.0780669, 0.1091772, -0.080...
Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study.
Biomechanical factors may play a role in osteoarthritis (OA) development and progression. Previous biomechanical studies have indicated that types of footwear may modulate forces across the knee joint, and high heeled womens' shoes in particular are hypothesised to be detrimental to lower limb joint health. This analys...
25,240,981
[ 0.3226303, 0.381497, -0.129999, 0.3796657, 0.02984133, -0.279364, -0.03193059, 0.2293065, 0.04831268, -0.2188784, -0.005038056, -0.1423194, 0.218265, -0.2247631, 0.1522375, -0.134162, 0.03620169, 0.2580936, -0.1100489, 0.1185346, -0.003580047, 0.1324492, -0.1182807, 0.2...
The use of high-speed, continuous, T2-weighted magnetic resonance sequences and saline for the evaluation of swallowing.
To introduce a new high-speed, continuous, T2-weighted magnetic resonance imaging (MRI) technique for the evaluation of swallowing by visualizing the flow of saline. In 20 healthy participants, high-speed (10 frames per second), continuous MRI of the pharynx and larynx was performed during administration of 5 mL of sal...
25,240,997
[ -0.1777762, -0.04134652, -0.3169731, -0.09679645, 0.1023633, -0.1974434, -0.1312441, -0.1871147, -0.225577, -0.134249, -0.000421701, 0.02067721, -0.0378749, -0.3195854, -0.1686345, -0.2734131, 0.01993654, 0.1246609, -0.3079726, -0.2157917, 0.3010784, 0.124017, -0.01729203...
Direct optimization of signal-to-noise ratio of CPMG-like sequences in inhomogeneous fields.
The performance of the standard CPMG sequence in inhomogeneous fields can be improved with the use of broadband excitation and refocusing pulses. In previous work we have developed short composite broadband refocusing pulses together with practical excitation pulses to realize such performance gains, and quantified the...
25,241,006
[ -0.03272747, 0.2412799, -0.2795034, -0.3952759, -0.04656773, -0.4449441, -0.2288749, 0.00381197, 0.1724494, -0.3704757, -0.3267102, -0.4367153, 0.1526573, 0.2968626, -0.2070002, -0.007991479, -0.5914748, -0.2183653, -0.4289644, 0.09020201, 0.2493176, -0.01301571, -0.08185...
Assessment of pretend play in Prader-Willi syndrome: a direct comparison to autism spectrum disorder.
Children with Prader-Willi syndrome (PWS) are at risk for autism spectrum disorder (ASD), including pervasive social deficits. While play impairments in ASD are well documented, play abilities in PWS have not been evaluated. Fourteen children with PWS and ten children with ASD were administered the Autism Diagnostic Ob...
25,241,008
[ -0.1064265, 0.09064915, -0.3360069, -0.01481933, 0.3557559, -0.08271184, 0.0508408, 0.02736351, 0.1650805, -0.1188105, 0.191091, 0.1435515, -0.2882476, -0.4979481, -0.4344799, -0.06971263, -0.05100307, 0.1589349, -0.08688266, -0.04728336, 0.1518545, -0.00439691, -0.187385...
New devices and technology in interventional cardiology.
There have been substantial improvements made in the tools and techniques used since the advent of percutaneous coronary intervention. What was primarily developed as a treatment of coronary artery disease is now used to address a variety of structural heart disease problems. The outcomes have been remarkably successfu...
25,241,014
[ -0.09486673, 0.1243066, -0.2800915, -0.1255975, -0.2076534, 0.02386428, -0.1657414, -0.1274124, 0.02259296, -0.03588184, 0.2208813, 0.1617052, -0.2202026, -0.4399655, -0.07618867, -0.252925, -0.4869633, -0.1087912, 0.06821311, -0.07698287, 0.04788707, 0.135776, -0.2749166...
Mechanical changes in human dental pulp stem cells during early odontogenic differentiation.
Cell adhesion and migration in bioactive scaffolds require actin cytoskeleton remodeling and focal adhesion formation. Additionally, human dental pulp stem cells (hDPSCs) undergo several changes in their mechanical properties during odontogenic differentiation. The effect of factors essential for odontogenesis on actin...
25,241,024
[ 0.2290876, 0.04738827, -0.002181743, 0.3586535, 0.04527963, -0.2370857, 0.06313891, 0.4446381, 0.1798196, 0.2903579, -0.00121057, -0.01631589, -0.3797734, -0.2935137, -0.2597254, -0.4285549, -0.3738527, 0.2321026, -0.1321495, -0.170741, 0.313328, 0.04171275, -0.2269796, ...
Psychical research in the history and philosophy of science. An introduction and review.
As a prelude to articles published in this special issue, I sketch changing historiographical conventions regarding the 'occult' in recent history of science and medicine scholarship. Next, a review of standard claims regarding psychical research and parapsychology in philosophical discussions of the demarcation proble...
25,241,025
[ -0.2159142, -0.153958, 0.0940503, 0.1423467, 0.1749294, -0.1922029, -0.4238026, -0.02938242, 0.321822, -0.1335577, 0.4013988, 0.1139637, -0.08152746, 0.1146887, -0.4542827, 0.1931641, 0.2833093, 0.1865522, -0.03013322, -0.1915743, -0.2099093, 0.1856596, -0.1749678, -0.0...
Attention and recognition biases associated with stature dissatisfaction among young men in China.
This research evaluated information-processing biases related to height dissatisfaction among young Chinese men. In Study 1, 32 highly stature dissatisfied (HSD) men and 36 less stature dissatisfied (LSD) men performed a dot probe task featuring height-related words and neutral words. HSD men were significantly slower ...
25,241,032
[ 0.08177185, 0.03203518, 0.2162502, 0.121005, 0.1553897, -0.02166462, -0.1087683, 0.09012751, -0.1612027, -0.1107347, 0.2797547, 0.3144388, -0.1181918, 0.264023, -0.3628181, 0.015224, -0.5590606, 0.189073, -0.02218564, 0.003514845, 0.2391992, 0.1780904, -0.1753822, 0.007...
Vertical expandable prosthetic titanium rib (VEPTR): a review of indications, normal radiographic appearance and complications.
Vertical expandable prosthetic titanium rib (VEPTR) is increasingly used in the treatment of thoracic insufficiency, idiopathic and neuromuscular scoliosis and chest wall defects in children. In contrast to spinal fusion surgery, the VEPTR allows for growth while stabilizing the deformity. We illustrate the common indi...
25,241,040
[ -0.01621229, 0.1511688, -0.1679036, -0.2262891, -0.2295431, -0.2522052, -0.3165721, 0.04123263, 0.1870496, 0.1688405, 0.1437321, -0.1432281, -0.1651571, 0.0293322, -0.16369, -0.1118077, -0.6252849, 0.1618127, 0.3527121, -0.4262453, 0.1756033, 0.1354165, -0.01637592, -0....
Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for reduced neuronal integrity in the anterior cingulate.
Neuroimaging studies have suggested that dysfunction of the cortico-striatal-thalamo-cortical (CSTC) circuit is a key pathophysiologic feature of obsessive-compulsive disorder (OCD). Several studies using proton magnetic resonance spectroscopy ((1)H MRS) have found abnormal neural metabolite concentrations among OCD pa...
25,241,042
[ 0.1698785, 0.02254058, 0.1630241, -0.04823579, -0.1629483, -0.1708119, -0.126321, 0.11169, -0.08948904, 0.2402577, -0.1376564, 0.5710081, -0.1096593, 0.4015825, -0.4998449, -0.1728261, -0.2309117, 0.2221913, -0.1773323, 0.2556735, 0.118824, -0.02798099, 0.03734939, 0.01...
Fingerprinting sedimentary and soil units by their natural metal contents: a new approach to assess metal contamination.
One of the major issues when assessing soil contamination by inorganic substances is reliable determination of natural metal concentrations. Through integrated sedimentological, pedological and geochemical analyses of 1414 (topsoil/subsoil) samples from 707 sampling stations in the southern Po Plain (Italy), we documen...
25,241,058
[ -0.05213816, 0.3554741, 0.2017767, -0.264416, -0.01164696, -0.03833436, 0.03867256, 0.1155737, -0.02432371, 0.08109152, -0.2636265, -0.2784248, -0.1890439, 0.05257566, -0.5408538, 0.2278957, -0.2095153, 0.4253175, 0.07062753, 0.3701651, 0.2461364, 0.5562943, -0.2587381, ...
Prefrontal dopamine in associative learning and memory.
Learning to associate specific objects or actions with rewards and remembering the associations are everyday tasks crucial for our flexible adaptation to the environment. These higher-order cognitive processes depend on the prefrontal cortex (PFC) and frontostriatal circuits that connect areas in the frontal lobe with ...
25,241,063
[ 0.07153602, 0.03122682, -0.1523221, -0.1242942, 0.3079998, -0.5001062, 0.04678118, -0.2974958, 0.03896698, 0.1944155, -0.08037646, 0.0805572, 0.04345409, -0.02428275, -0.3263305, -0.4071321, -0.4477004, 0.1169404, 0.03449463, 0.1946369, -0.03479182, -0.006504469, -0.28365...
In vivo mitochondrial inhibition alters corticostriatal synaptic function and the modulatory effects of neurotrophins.
Experimental evidence has revealed the role of mitochondria in various aspects of neuronal physiology. Mitochondrial failure results in alterations that underlie the pathogeneses of many neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease (HD) and amyotrophic lateral scle...
25,241,069
[ -0.2286618, -0.2687215, -0.02741825, -0.08711328, 0.2300905, -0.2686857, 0.3196276, -0.4393319, 0.1564095, -0.08282689, -0.3171968, -0.2597435, 0.0008263202, -0.1130768, -0.3924902, 0.08184877, -0.3433838, -0.1077326, -0.08093312, 0.1930441, 0.1503364, 0.1982196, 0.200432...
Striatal circuits, habits, and implications for obsessive-compulsive disorder.
Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions coul...
25,241,072
[ 0.1225357, 0.1492251, 0.1208721, -0.3208389, 0.1352491, -0.3166474, -0.1468986, -0.3093621, 0.03002425, 0.02559288, 0.1217907, 0.3351917, -0.1688732, -0.02841944, -0.3475065, -0.0338065, -0.3695159, 0.1571385, 0.01550729, 0.1440939, -0.147095, 0.07622115, -0.146812, 0.0...
Complex lymphatic anomalies.
Complex lymphatic anomalies include several diagnoses with overlapping patterns of clinical symptoms, anatomic location, imaging features, hematologic alterations, and complications. Lymphatic malformations likely arise through anomalous embryogenesis of the lymphatic system. Analysis of clinical, imaging, histologic, ...
25,241,096
[ 0.3817374, -0.0789415, 0.06234979, -0.4101027, -0.2136692, -0.2995805, -0.1666259, 0.06369063, 0.1774877, -0.1344943, 0.1146538, -0.166698, -0.1702347, 0.0536461, -0.3480452, 0.1072751, -0.3294756, -0.1886242, 0.6373415, 0.1722337, 0.2975862, 0.1180368, -0.2522527, 0.27...
Arteriovenous malformations.
Arteriovenous malformations (AVMs) are fast-flow vascular malformations composed of a complex vessel network directly connecting feeding arteries to draining veins. The intervening normal capillary network is absent. Proper diagnosis and treatment of AVMs is challenging and in need of an interdisciplinary team of exper...
25,241,099
[ -0.1701931, 0.2384426, -0.1544866, -0.1013581, 0.2336598, -0.304179, -0.1454391, 0.02172345, -0.04945584, -0.08869898, 0.0936257, 0.3651559, -0.282385, -0.3933746, -0.4655214, -0.1677266, -0.3746184, 0.2595297, 0.187966, -0.16647, 0.1341565, 0.07453598, -0.02192803, 0.0...
Antibacterial effect of crude extract and metabolites of Phytolacca americana on pathogens responsible for periodontal inflammatory diseases and dental caries.
The oral cavity is the store house of different species of microorganisms that are continuously engaged in causing diseases in the mouth. The present study was conducted to evaluate the antibacterial potential of crude extracts of the aerial parts of Phytolacca americana and its natural compounds against two oral patho...
25,241,105
[ -0.1955086, 0.1417497, -0.04787233, 0.129903, -0.3441399, 0.1710939, -0.03057926, 0.3544316, 0.2513424, -0.356389, 0.1588122, 0.003614782, -0.2658111, -0.1894984, -0.3376966, 0.08677235, -0.2610636, 0.3680897, 0.06564101, 0.07200397, 0.3321522, 0.04920651, -0.2596568, 0...
Assessment of cardiorespiratory and neuromotor fitness in children with developmental coordination disorder.
The decreased participation in physical activity by children with probable developmental coordination disorder (pDCD) has raised concerns about their aerobic fitness and lung function levels. The purpose of the present study was to examine assessment of cardiorespiratory and neuromotor fitness, using laboratory-based t...
25,241,114
[ -0.2259728, -0.0293655, -0.08597337, -0.2135919, 0.1508853, -0.3107591, -0.3770187, -0.1058421, -0.5952964, -0.3316199, 0.2442349, 0.2281739, -0.103691, -0.07306798, -0.01364466, -0.3197957, -0.6000219, 0.1711821, -0.3712627, 0.2259866, -0.1474016, -0.003638335, 0.1701241...
SAHA-based novel HDAC inhibitor design by core hopping method.
The catalytic activity of the histone deacetylase (HDAC) is directly relevant to the pathogenesis of cancer, and HDAC inhibitors represented a promising strategy for cancer therapy. SAHA (suberoanilide hydroxamic acid), an effective HDAC inhibitor, is an anti-cancer agent against T-cell lymphoma. However, SAHA has adve...
25,241,128
[ -0.08927248, 0.09079967, -0.2001936, -0.07966246, 0.2224226, -0.03557895, -0.1609436, 0.4364544, 0.07340772, 0.0397424, 0.3231122, 0.1001084, -0.002507636, 0.1916749, -0.391438, 0.1944369, -0.1906851, 0.03723032, -0.03894112, 0.06380915, -0.05032955, 0.6988494, -0.2615829...
SDS-PAGE and IR spectroscopy to evaluate modifications in the viral protein profile induced by a cationic porphyrinic photosensitizer.
Reactive oxygen species can be responsible for microbial photodynamic inactivation due to its toxic effects, which include severe damage to proteins, lipids and nucleic acids. In this study, the photo-oxidative modifications of the proteins of a non-enveloped T4-like bacteriophage, induced by the cationic porphyrin 5,1...
25,241,141
[ -0.1438503, 0.07388288, -0.05542361, -0.0007196604, 0.006062617, -0.1887117, -0.05846822, -0.07587505, 0.3077568, 0.009626484, -0.12136, -0.07890656, -0.3640116, -0.1125426, -0.4217929, 0.312087, -0.4913137, 0.07285552, -0.1367711, 0.1574583, -0.006098337, 0.4232325, 0.06...
Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration.
We developed an intra-articular (IA) drug delivery system to treat osteoarthritis (OA) that consisted of kartogenin conjugated chitosan (CHI-KGN). Kartogenin, which promotes the selective differentiation of mesenchymal stem cells (MSCs) into chondrocytes, was conjugated with low-molecular-weight chitosan (LMWCS) and me...
25,241,157
[ 0.1346867, 0.04986232, 0.01877642, -0.11488, -0.1384293, 0.07627524, -0.005139655, 0.3188565, -0.02144269, 0.1340926, -0.1008402, 0.09732759, 0.1711833, -0.09878538, -0.438453, 0.1708666, -0.1947107, 0.1350387, 0.2446211, -0.008765582, -0.08603689, -0.1786786, 0.1444437, ...
Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells.
Gpn1 and Gpn3 are GTPases individually required for nuclear targeting of RNA polymerase II. Here we show that whereas Gpn3-EYFP distributed between the cytoplasm and cell nucleus, it was mainly cytoplasmic when coexpressed with Gpn1-Flag. Gpn3-Flag retained Gpn1-EYFP in the cytoplasm. However, Gpn3-EYFP/Gpn1-Flag nucle...
25,241,168
[ 0.06852937, -0.01350052, -0.2832528, -0.01984381, 0.08569904, -0.1884456, -0.1439478, 0.07882614, -0.1783773, 0.02656547, -0.002812393, 0.1049758, 0.07222421, 0.07846096, -0.01833826, -0.095608, -0.6335538, -0.07482171, -0.1808164, 0.01045056, 0.4781242, 0.04888292, -0.06...
Weighted diagnostic criteria for developmental dysplasia of the hip.
To establish clinical diagnostic criteria for developmental dysplasia of the hip (DDH) that model the practices of expert clinicians. Of 23 clinical criteria for the diagnosis of DDH, ranked in order of diagnostic importance by international consensus, the 7 most highly ranked were placed in all possible combinations t...
25,241,185
[ -0.05174237, 0.04860498, 0.0445042, 0.02244665, 0.3886703, -0.426473, -0.3006325, 0.1058125, -0.09958167, -0.3947839, 0.1205071, 0.2319635, -0.1813426, -0.262874, -0.2520141, -0.05970054, -0.4339128, 0.381392, -0.04607246, -0.2415469, 0.2666293, -0.08222996, 0.07710604, ...
Deployment-related depression screening, 2001-2008: comparing clinical versus research surveys.
Potential adverse mental health effects of deployment, including depression, are an ongoing concern. Although a previous study assessed under-reporting of depression on post-deployment health assessments compared to anonymous surveys, those results were not examined at the individual level to identify demographic or mi...
25,241,198
[ -0.1807761, -0.09888157, -0.05941335, -0.2686225, -0.07943767, -0.08980773, -0.2064634, 0.09898973, 0.1502921, -0.02757553, 0.004000959, 0.1997439, 0.1875894, -0.08778251, -0.1208903, -0.138101, -0.2948816, 0.3747801, 0.06990488, -0.4117501, -0.1209978, 0.1025521, -0.0394...
Monopolar electromyographic signals recorded by a current amplifier in air and under water without insulation.
It was recently proposed that one could use signal current instead of voltage to collect surface electromyography (EMG). With EMG-current, the electrodes remain at the ground potential, thereby eliminating lateral currents. The purpose of this study was to determine whether EMG-currents can be recorded in Tap and Salt ...
25,241,214
[ -0.1899702, -0.003067504, -0.3475475, -0.09286498, -0.1688509, -0.4326544, -0.4727034, -0.009823889, 0.03333361, -0.2071274, 0.002040739, -0.1738272, 0.03694572, -0.1344389, -0.2732942, -0.1186324, -0.4417345, -0.1169963, -0.325784, -0.2299254, 0.09456422, 0.1032578, 0.04...
Breast cancer during follow-up and progression - A population based cohort on new cancers and changed biology.
Emerging data indicate an important role for biopsies of clinically/radiologically defined breast cancer 'recurrences'. The present study investigates tumour related events (relapses, other malignancies, benign conditions) after a primary breast cancer diagnosis. The cohort includes 2102 women, representing all patient...
25,241,230
[ 0.05563166, -0.2721363, -0.01241837, -0.339988, -0.01342487, -0.445116, 0.04597411, 0.08994177, -0.01808731, 0.1992173, -0.149177, 0.173899, 0.2592804, -0.1763968, -0.307657, -0.3012229, -0.04027002, 0.0149701, 0.1631789, 0.1839547, 0.2500345, 0.407273, -0.2520722, -0.1...
Regulation of the transbilayer movement of diacylglycerol in the plasma membrane.
This mini-review presents recent advances in the regulation of the membrane transbilayer movement (or flip-flop) of diacylglycerol (DAG), a key intermediate in lipid metabolism and a second messenger in lipid-mediated signaling. Despite progresses in lipid biophysics and imaging, little is known about the DAG dynamics ...
25,241,257
[ -0.2701835, -0.06361008, -0.2645024, -0.3372469, 0.04050891, -0.2514506, -0.09131014, 0.1722505, -0.2195674, -0.0411709, -0.02676178, -0.08452392, -0.2241409, 0.1142458, -0.6454646, -0.1451347, -0.498955, 0.03954873, -0.1391988, -0.03151676, 0.3458007, 0.4042959, -0.23951...
Prevalence of Escherichia coli sequence type 131 and its H30 subclone among E. coli isolates in a French hospital.
The prevalence of Escherichia coli sequence type 131 (ST131) and its subclone H30 was assessed among a collection of 490 E. coli isolated in 2013 in a French university hospital. The prevalence of ST131 was 4% among bloodstream isolates (regardless of antimicrobial resistance) and 17.2% among extended-spectrum β-lactam...
25,241,262
[ 0.003898915, 0.0244887, 0.1288262, 0.01210555, -0.02198726, 0.002446731, -0.003261967, -0.2417847, -0.07863095, 0.2906237, 0.2234051, 0.3181705, 0.02112132, -0.09036566, -0.0947063, -0.4002834, -0.2988321, 0.2079113, -0.06075949, -0.0831226, 0.3549201, -0.2864896, 0.11941...
Histone deacetylase inhibition enhances the lymphomacidal activity of the anti-CD22 monoclonal antibody HB22.7.
HB22.7, an anti-CD22 monoclonal antibody has shown consistent preclinical activity against non-Hodgkin lymphoma (NHL). Histone deacetylase inhibitors (HDACi) have demonstrated efficacy in lymphoma and can modulate cell surface receptor expression. To augment the lymphomacidal activity of HB22.7 we examined the combinat...
25,241,275
[ -0.009012565, -0.103114, -0.172951, -0.2110487, 0.1176721, -0.1144113, -0.2079805, 0.3282028, -0.07178611, 0.02919948, 0.04492554, 0.3504528, 0.2236736, -0.2165595, 0.01759854, -0.07270521, -0.4391881, 0.03790754, -0.1566681, -0.04595486, -0.1204369, 0.0856567, -0.0362463...
Hole-pin joining structure with fiber-round-hole distribution of lobster cuticle and biomimetic study.
Observations of the cuticle of the Boston Spiny Lobster using scanning electron microscope (SEM) show that it is a natural biocomposite consisting of chitin fibers and sclerotic-protein matrix with hierarchical and helicoidal structure. The SEM images also indicate that there is a hole-pin joining structure in the cuti...
25,241,280
[ 0.1622089, -0.01706981, -0.002622492, 0.1052619, -0.08627209, -0.2238046, -0.134974, 0.418711, 0.5015523, 0.1031023, 0.04584605, -0.2486369, -0.1266184, -0.2793274, -0.5782498, 0.2409387, -0.3404451, 0.03968349, 0.3156089, -0.2957674, 0.137304, 0.1276975, -0.09231474, -...
Processing and mechanical behavior of lamellar structured degradable magnesium-hydroxyapatite implants.
Multilayered (laminated) composites exhibit tunable mechanical behavior compared to bulk materials due to the presence of more interfaces and therefore magnesium based composites are gaining wide popularity as biodegradable materials targeted for temporary implant applications. The objective of the present work is to f...
25,241,282
[ -0.3038886, 0.386418, 0.0422211, -0.2038881, -0.1976827, -0.2725069, 0.02700622, 0.1641927, 0.04204583, 0.1763775, 0.1763241, -0.1984618, -0.09698947, -0.4238108, -0.2657923, 0.07134743, -0.07248961, -0.02556892, -0.1594775, -0.132439, 0.4594162, -0.000378464, 0.1522238, ...
Endoluminal release of ureteral ligature after hysterectomy.
Iatrogenic ureteral injury is a well-recognized complication of abdominal total hysterectomy. We report a case of a 57-year-old female who underwent abdominal total hysterectomy for a uterine myoma and experienced severe right flank pain postoperatively. The imaging study displayed an obstruction of the right distal ur...
25,241,286
[ -0.1550266, 0.2002175, -0.4672382, -0.07703078, -0.04201445, -0.08286123, -0.1833116, -0.2032127, 0.1740968, 0.0348629, 0.2190847, 0.1749257, 0.09168678, -0.3116316, -0.08654387, 0.09878659, -0.3060021, 0.1869284, 0.021379, -0.7491095, 0.1394852, 0.2084216, -0.2636066, ...
Critical limb ischemia and the diseased popliteal artery.
The unique anatomical location and particular biomechanical factors affecting the popliteal artery provide a challenge to determine the proper endovascular, surgical, or combined intervention for patients with critical limb ischemia who often require prompt management in the presence of severe lifestyle-limiting sympto...
25,241,317
[ 0.07141382, 0.2491658, -0.2178662, 0.1044758, -0.06806687, -0.08160501, -0.09190372, 0.008432817, -0.07004736, -0.02884918, 0.005185143, -0.01883918, -0.1391239, -0.4051596, -0.01935139, -0.02260812, -0.3338735, 0.1557173, -0.06597797, 0.2108804, 0.01897604, 0.1538272, -0...
Tibiopedal access for lower extremity arterial intervention: when to use and how to perform.
Tibiopedal artery access is being used with increasing frequency as an alternative access to facilitate procedural success in lower extremity arterial intervention. This technique is usually employed in the setting of critical limb ischemia and tibial artery intervention, but it may offer potential practical advantages...
25,241,320
[ -0.2102396, 0.06335182, -0.05143966, -0.02068439, -0.1558129, -0.2894804, -0.2202546, 0.09947554, -0.2038166, 0.1976288, -0.1046588, -0.1506709, -0.1669009, -0.4671412, -0.1294992, -0.1663764, -0.3560005, 0.001025638, -0.3369379, 0.008254251, -0.07799131, -0.006400664, 0....
Optimal use of atherectomy in critical limb ischemia.
Critical limb ischemia (CLI) is the most severe and debilitating form of peripheral arterial disease and is associated with high rates of limb loss and cardiovascular mortality. The unique physical environment of tibial occlusive disease underlying most CLI cases limits treatment options and long-term durability, with ...
25,241,322
[ 0.09494502, 0.1539158, -0.1436847, 0.1148863, 0.001609872, -0.1879017, -0.09896941, 0.02053719, -0.001817198, -0.2299513, -0.1377707, 0.008889381, 0.01980279, -0.08857391, 0.2723951, -0.2719471, -0.3752509, 0.02729222, -0.04001649, 0.1292106, -0.1954962, 0.2421699, -0.045...
Outpatient follow-up for critical limb ischemia.
Outpatient follow-Up for critical limb ischemia offers the clinician the opportunity to monitor the patient for risk factor modification and wound healing. Routine surveillance following intervention will improve long-term patency.
25,241,323
[ -0.06952541, 0.264387, -0.3743448, -0.1205138, 0.006948044, -0.1433028, -0.2438606, 0.05455715, 0.135257, -0.3076608, 0.001453681, 0.1420405, -0.05046702, -0.2874743, -0.0488659, -0.183303, -0.2819166, 0.07250726, -0.09914508, 0.1898486, -0.2117988, -0.04654556, -0.026787...
Development of the Lémann index to assess digestive tract damage in patients with Crohn's disease.
There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lémann Index and assessed its ability to measure cumulative structural bowel damage in...
25,241,327
[ 0.2049572, -0.1086886, 0.1497037, -0.07401039, 0.3156096, -0.4803419, 0.01133317, 0.05137017, 0.4108022, -0.2432287, 0.05612721, -0.3973995, 0.09659762, 0.025011, -0.02757929, -0.06700864, -0.7723814, -0.1018661, 0.04103625, 0.1531793, 0.02946151, 0.291655, -0.1728163, ...
Peripheral mechanisms in appetite regulation.
Peripheral mechanisms in appetite regulation include the motor functions of the stomach, such as the rate of emptying and accommodation, which convey symptoms of satiation to the brain. The rich repertoire of peripherally released peptides and hormones provides feedback from the arrival of nutrients in different region...
25,241,326
[ -0.1400024, -0.2334194, -0.3313517, -0.457904, 0.2331004, -0.4776757, -0.005023426, 0.1452743, 0.08780525, 0.1345979, 0.1309094, -0.2983531, 0.03842733, -0.2476971, -0.281043, -0.1383414, -0.4733064, -0.03242123, 0.0875687, -0.1300868, -0.2422742, 0.1223984, -0.2547946, ...
Efficacy and safety of tocilizumab in elderly patients with rheumatoid arthritis.
To assess the safety and efficacy of tocilizumab (TCZ) in elderly (≥65 years) rheumatoid arthritis (RA) patients treated in daily practice. We conducted a retrospective study of TCZ use in RA patients in five French university hospitals between 2009 and 2012. We considered two age groups, under 65 years (<65) and ov...
25,241,333
[ 0.2415739, 0.1010939, -0.104221, -0.251155, -0.05311931, -0.3962318, 0.01918338, 0.1011326, -0.4066089, -0.1276177, -0.05276927, 0.4030876, 0.0125442, -0.09923527, -0.02407704, -0.2486652, -0.06817123, -0.08192446, -0.1061142, 0.2468431, 0.1401421, 0.3684669, 0.02425866, ...
Unplanned or unwanted? A randomized study of national estimates of pregnancy intentions.
To evaluate the effect of question wording on national estimates of pregnancy intentions. Data drawn from a national probability survey. The FECOND study in France in 2010. Five thousand two hundred and seventy-two women and 3,373 men who reported 11,603 pregnancies. Participants randomly assigned to answer 1 of 2 ques...
25,241,373
[ -0.05288365, 0.157244, -0.09873094, 0.1313939, 0.4497698, -0.2676758, -0.006333978, -0.2754464, -0.01480217, -0.03939133, 0.04704687, 0.1988024, -0.259211, -0.05006667, -0.04562538, -0.342681, -0.2275948, -0.03280321, -0.3147261, 0.1789343, 0.2747669, 0.2774999, 0.0046104...
Relationship between rate of infection and markers of inflammation/immunity in Holy Birman cats with feline coronavirus.
The aim of this study was to assess whether Holy Birman cats (HB) have a peculiar immune profile and a higher rate of infection by feline coronaviruses (FCoV). Leucocyte and lymphocyte subsets, antibody titers, α1-acid glycoprotein (AGP), globulin fractions, IL-4, IL-12 and IFN-γ in blood and fecal FCoV excretion were ...
25,241,387
[ -0.244577, 0.09754153, -0.3212127, -0.1303039, 0.1458427, -0.4000609, -0.0906359, -0.1577751, -0.2452797, 0.09640651, 0.03710928, 0.0242551, 0.3011763, -0.1517468, -0.1463188, -0.132905, -0.4404505, 0.02480959, 0.4354378, 0.1926234, -0.3470488, -0.07638638, -0.4893456, ...
The relationship of obesity and weight gain to childhood teasing.
This article examines the relationship between weight gain and childhood teasing in children. Anthropometric data and self-reported teasing experiences were collected on a sample of second and third graders at a local elementary school in a disadvantaged suburban community. The study model uses bio-ecological developme...
25,241,400
[ -0.012011, 0.2789328, -0.4858794, 0.08557765, 0.07355437, -0.1773502, -0.5112284, -0.07962685, 0.05418142, -0.106167, 0.05522656, -0.004900466, -0.5118989, -0.06653304, -0.5014831, 0.2848195, -0.1985652, 0.2556033, 0.2883791, 0.2119036, -0.2377822, 0.6549148, -0.104126, ...
Understanding and managing myeloma.
Multiple myeloma cannot be cured and treatment can be complex. This article outlines the pathophysiology of the condition, together with the diagnostic process and the available treatment options.
25,241,434
[ -0.1222672, 0.1894214, 0.1104356, -0.34931, -0.09077687, -0.1852432, -0.1302931, 0.1349775, 0.08193551, -0.01667655, 0.1680341, 0.2939666, 0.02376283, -0.1032926, -0.2466796, -0.2478622, -0.00009542598, 0.03418262, -0.006873097, -0.1228912, 0.2122231, 0.1278343, -0.086486...
How to boost a low-morale medical practice team: twenty-five strategies.
Low morale can decrease productivity and cooperation among medical practice employees, and increase work errors, absenteeism, and turnover. That is why practice managers must be mindful of their employees' morale and develop a toolkit of strategies that they can use to assess and boost waning morale. This article sugge...
25,241,449
[ -0.2631104, 0.5082824, 0.02966113, -0.02522242, 0.09572889, -0.06740762, -0.2295228, 0.1601373, 0.1456326, -0.1608686, 0.221205, 0.08130857, 0.0404138, -0.05873522, -0.6602633, 0.08035032, -0.31982, -0.01310019, -0.04480042, -0.08457509, 0.3003966, 0.2103439, 0.06125592, ...
Maximizing collections from patient services billing.
The field of medical billing and collections continues to evolve along with current developments in U.S. healthcare reform. Although there has been a significant shift of payment responsibility from third-party payers to patients, many practices are not equipped to handle this change. As patients' financial obligations...
25,241,445
[ -0.2217246, 0.07020421, -0.01301256, -0.05391749, -0.0603254, -0.2837977, -0.1545518, 0.2042383, 0.05950368, 0.1891586, 0.1999269, 0.02557062, -0.2802373, -0.1064833, -0.1947074, -0.05672922, 0.2984499, -0.2548943, -0.09111624, -0.2442052, 0.2105512, -0.022847, -0.1735704...
[Regulating effect of anodonta glucan HBP-A on chondrocytes through Wnt pathway].
To investigate regulation function of anodonta glucan HBP-A on chondrocytes through Wnt pathway in vitro. Rat chondrocytes were cultured and differentiated induced with IL-1beta (10 ng/ml) in vitro. Chondrocytes were divided into five groups:IL-13 group,IL-1beta + IWP-2 (5 microM,Wnt pathway inhibitor) group, IL-1beta ...
25,241,462
[ -0.09670983, 0.1447758, -0.1901618, 0.04426807, -0.05274618, -0.5195339, -0.4465648, -0.1432795, 0.1290608, -0.2409153, 0.06898833, 0.4082428, -0.1682782, -0.4838931, -0.3520062, 0.05928652, -0.211223, 0.03817663, -0.3259576, 0.1239232, 0.5214112, 0.08233663, -0.08561411,...
[Extorsion traction and pushing manipulation with fingers for the treatment of anterior shoulder dislocation in elderly].
To investigate a manipulating therapy for treatment of anterior shoulder dislocation in elderly. From October 2011 to June 2012,27 elderly patients with anterior shoulder dislocation were treated by extorsion traction and pushing manipulation with fingers, including 7 males and 20 females aged from 65 to 86 years old w...
25,241,476
[ -0.4850443, 0.3938183, 0.2009129, 0.04170066, 0.3104632, -0.3356982, -0.331887, 0.3202597, 0.097624, 0.3735914, 0.0477916, -0.1128309, -0.4805329, -0.3600881, 0.2647201, -0.06032624, -0.2175384, 0.02647157, -0.3969114, -0.1051987, 0.2571665, 0.1060165, -0.2430551, -0.16...
Pastoral counseling in the 21st century: the centrality of community.
In this article, I argue that the notion of ecclesia or faith community is a central, existential anthropological premise that can shape how we understand facets of pastoral counseling such as diagnosis, process, and aims. Implicit here is the idea that the distinctiveness of pastoral counseling lies not simply in acco...
25,241,493
[ -0.03707897, 0.1837061, 0.1597714, -0.0403522, 0.1255857, -0.1335803, -0.4365654, -0.05735904, 0.3010184, 0.3892104, -0.02320493, -0.0182268, -0.291022, 0.02430634, -0.3101691, -0.1016866, -0.1449074, 0.224798, -0.1292108, -0.125711, 0.1520818, 0.2953507, -0.03746501, -...
Pedagogical progeniture or tactical translation? George Fordyce's additions and modifications to William Cullen's philosophical chemistry--Part I.
This article contributes to a growing body of research on the dissemination, dispersion or diffusion of scientific knowledge via pedagogical networks. By examining students' handwritten lecture notes, I compare the eighteenth-century chemistry lectures given by William Cullen (1710-1790) at Glasgow and Edinburgh Univer...
25,241,503
[ -0.1459184, 0.1118438, 0.1183743, -0.3393757, 0.3964696, -0.1526924, -0.1869751, -0.1226556, -0.04334743, 0.2675039, 0.1599061, 0.2852319, 0.1144334, 0.05459058, -0.2906884, 0.2323264, 0.007851724, -0.3925022, -0.2807032, 0.1692266, 0.08350528, 0.2701541, -0.05905166, 0...
Does fluoride gel/foam application time affect enamel demineralization?
The American Dental Association Council on Scientific Affairs recommends a four-minute application of professionally applied topical fluoride, based on clinical evidence for caries reduction. However, some product manufacturers imply that a one-minute application is sufficient. The purpose of this laboratory study was ...
25,241,499
[ -0.2434953, 0.1320748, -0.1587089, 0.2741199, 0.2280611, -0.3092569, 0.08012911, -0.03420686, 0.1950575, -0.3346539, -0.03458416, 0.006343686, -0.1379529, -0.2201549, 0.1008183, -0.4370737, -0.2846754, -0.03859347, -0.3446157, -0.2925421, 0.1338797, 0.3513039, -0.1062565,...
[Minimally invasive treatment of tibial plateau fracture under arthroscopy monitoring].
Twenty six patients with fracture of tibial plateau was under arthroscopy assisted reduction, the joint surface of bone graft, and USES the steel plate fixation treatment. Average surgery time was 65 min (70-120 min), average fracture healing time was 15 weeks (12-17 weeks), joint surface anatomical reattachment rate w...
25,241,526
[ 0.1425975, 0.4138227, 0.2111303, -0.1679551, -0.1487571, -0.1375889, 0.03551186, 0.3283193, 0.02355439, -0.008551088, -0.138477, -0.4453955, 0.04966246, 0.03976652, -0.2829031, -0.3971514, -0.194438, -0.009460227, 0.2583689, 0.1846229, 0.2303558, 0.1695825, -0.1263025, ...
[Piezosurgery for surgically assisted rapid maxillary expansion under local anesthesia].
This study evaluates piezosurgery for surgically assisted rapid maxillary expansion (SARME) under local anesthesia. SARME was performed on adults with maxillary transverse deficiency under local anesthesia with a piezosurgical device. Fourteen patients (six males and eight females) underwent lateral maxillary osteotomi...
25,241,535
[ -0.02707068, -0.2508225, 0.08288697, -0.1362241, -0.0197773, -0.09432778, 0.03627585, 0.02987234, 0.4429264, -0.3094067, 0.1132242, -0.433618, -0.08927909, -0.5496349, -0.3900161, -0.1399444, -0.5925003, -0.09369125, -0.04367926, -0.1399932, 0.04188028, 0.05913999, -0.266...
[Clinical application of primary tumor contralateral facial artery musculocutaneous flap to reconstruct oral and maxillofacial defects].
This study aims to explore the method that uses primary tumor contralateral facial artery musculocutaneous (FAMM) flap to reconstruct defects of the tongue and floor of mouth. Six cases were selected for the use of primary tumor contralateral FAMM flap to reconstruct tongue and floor of mouth defects after tumor resect...
25,241,536
[ -0.3135029, 0.03600769, 0.02541261, -0.3598397, 0.0419149, -0.03225639, 0.1341325, 0.2965363, 0.2837353, -0.1275267, -0.05020377, -0.03067778, 0.06463941, -0.1504224, -0.1566252, -0.1665485, -0.05170804, -0.1585804, 0.06584797, 0.04786099, 0.01229294, 0.1215171, -0.416933...
Treatment outcome of tuberculosis patients in a clinic of Bangalore.
A total of 112 cases (New = 101, previously treated = 11) were diagnosed as suffering from tuberculosis (TB) at a private clinic in Bangalore city. The clinic identified TB suspects, established diagnosis of TB, administered direct observation of treatment (DOT), maintained treatment cards and undertook defaulter retri...
25,241,566
[ -0.01324298, 0.227078, 0.07631543, -0.05899682, -0.1666158, -0.1989392, -0.2559226, -0.0567284, 0.3633073, -0.09276135, 0.1850377, 0.4634782, 0.03371607, 0.2031463, -0.2845119, -0.1636648, 0.03240896, -0.189904, 0.01295983, -0.1812085, -0.1388318, 0.2521441, -0.04237587, ...
Injection site abscess due to Mycobacterium tuberculosis following DPT vaccination.
Injection site abscesses are not so uncommon and usually bacterial in origin. Very occasionally, these are due to mycobacteria, particularly rapidly growing non-tuberculous mycobacteria. Mycobacterium tuberculosis is rarely implicated as a cause of injection site abscess as documented in this report following DPT vacci...
25,241,575
[ -0.2966417, -0.3165219, -0.2848466, -0.01774902, -0.008935873, -0.2356416, -0.4241384, -0.002457489, -0.1645882, -0.1358308, 0.1680531, -0.02992319, -0.04067355, -0.09481829, -0.2341197, -0.305576, 0.1294063, -0.0282463, 0.1860031, -0.08048564, 0.1089241, 0.1446717, -0.00...
In vivo redox effects of Aspidosperma quebracho-blanco Schltdl., Lantana grisebachii Stuck and Ilex paraguariensis A. St.-Hil. on blood, thymus and spleen of mice.
Argentinian native plants Aspidosperma quebracho-blanco, Lantana grisebachii and Ilex paraguariensis are known to have antiinflammatory and antioxidant properties. We demonstrated it in vivo by the redox changes in murine hemolymphatic tissues after infusive extract intake of these plants as revealed in organic trophis...
25,241,588
[ -0.01356121, -0.3952682, -0.3330737, -0.002032126, -0.09321067, 0.06953233, -0.05280283, -0.3921553, 0.1591264, -0.05276018, -0.007071759, -0.05885035, 0.2341622, -0.2468302, -0.5613229, 0.04199347, -0.692842, -0.2713609, 0.2703163, 0.4231388, -0.1788696, 0.3270636, -0.17...
Mass propagation of Cymbidium giganteum Wall. ex Lindl. using in vitro seedlings.
In vitro seedlings were used as explants for protocorm like bodies (PLBs) production which in turn were used for regeneration purpose. PLBs were induced from the base of seedlings (1.0-1.5 cm in size) in MS + BAP (8.88 microM). After 90 days of inoculation, PLBs production rate started declining and most of the PLBs tu...
25,241,591
[ -0.09720464, -0.2955568, -0.02951414, -0.168173, 0.1197308, -0.1913199, -0.3207237, -0.1016241, 0.04124128, -0.320917, -0.274155, 0.4688151, -0.06828526, 0.3724291, -0.4909057, 0.2565265, -0.8818925, -0.241, -0.03652719, 0.2237362, 0.4774532, 0.3104017, -0.07895027, 0.0...
In vitro regeneration in olive (Olea europaea L.) cv, 'Frontio' from nodal segments.
An efficient and reproducible protocol for plantlet regeneration from nodal segments of Olive cv 'Frontio' has been developed. Media and explants browning due to exudation of phenolics from the explants were controlled by fortification of the medium with 100 mg/L ascorbic acid. Best establishment of olive explants was ...
25,241,592
[ 0.402217, -0.2880997, -0.2852964, -0.1299823, 0.06011673, -0.1147345, -0.1839716, 0.1328496, 0.19416, -0.4527287, -0.1337322, 0.1861445, 0.2631859, 0.3207834, -0.4989172, -0.05557057, -0.4901599, 0.09777294, 0.09325258, 0.2431194, 0.195251, 0.1303538, -0.06871077, -0.09...
The impact of an integrated care service on service users: the service users' perspective.
The purpose of this paper is to examine the effects of an integration programme on service users from users' own perspective. Multi-method approach was used. Both quantitative and qualitative data collection and analysis were employed to uncover and examine service users' views of the impact of the integration programm...
25,241,596
[ 0.07362572, 0.1507168, -0.05223863, 0.03388633, -0.0080833, -0.1623435, -0.0928311, -0.1098539, -0.0400147, -0.005323504, 0.03624963, -0.5094373, -0.2729055, -0.2114599, -0.2409737, 0.05478106, 0.01886448, 0.2684553, -0.3437297, -0.07399923, 0.1207418, 0.283237, 0.2339136...