title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Synthesis and biological evaluation of 2'-substituted-4'-selenoribofuranosyl pyrimidines as antitumor agents. | The 2'-substituted-4'-selenoribofuranosyl pyrimidines 3a-3j were synthesized from D-ribose and assayed for anticancer activity. The 2'-azido and 2'-fluoro groups with a ribo configuration were introduced by the regioselective opening of the O2,2'-anhydronucleosides with sodium azide and (HF)x-pyridine, respectively. Am... | 25,239,109 | [
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Variants in angiogenesis-related genes and the risk of clear cell renal cell carcinoma. | Angiogenesis is fundamentally important to the pathogenesis of clear cell renal cell carcinoma (ccRCC). We investigated the association between variations of genes related to angiogenesis and the risk of ccRCC. In a case-control study of 859 ccRCC patients and 1004 cancer-free subjects, we genotyped 24 potentially func... | 25,239,121 | [
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An automated telephone nutrition support system for Spanish-speaking patients with diabetes. | In the United States, Spanish-speaking patients with diabetes often receive inadequate dietary counseling. Providing language and culture-concordant dietary counseling on an ongoing basis is critical to diabetes self-care. To determine if automated telephone nutrition support (ATNS) counseling could help patients impro... | 25,239,122 | [
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Stress is the rule rather than the exception for Metarhizium. | The insect pathogenic plant root symbiont Metarhizium experiences many situations that restrict its growth whether living in host insects or on plant roots. These include a range of physical, chemical and biological effects involving UV and extremes of temperature, pH, nutrient availability, toxic metals and other poll... | 25,239,135 | [
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Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents. | Expression of Satb2 (Special AT-rich sequence-binding protein-2) elicits expression of the vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) in cultured rat sympathetic neurons exposed to soluble differentiation factors. Here, we determined whether or not Satb2 plays a similar role in cho... | 25,239,161 | [
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Validity, reproducibility, and responsiveness of the oxford hip score in patients undergoing surgery for femoroacetabular impingement. | To examine the validity, reproducibility, and responsiveness of the Oxford Hip Score (OHS) in patients with femoroacetabular impingement (FAI). One hundred twenty-six consecutive patients with FAI and 550 patients undergoing total hip arthroplasty (THA) completed the OHS and the Hip Outcome Score (HOS) at baseline and ... | 25,239,174 | [
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Early postoperative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass. | Previous studies show that 'poor responders' to Roux-en-Y gastric bypass (RYGBP) may be identified on the basis of early postoperative weight loss. Early identification of poor responders could allow earlier provision of postoperative behavioural and/or intensive lifestyle interventions and enhance their maximal weight... | 25,239,175 | [
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Effect of γ-irradiation on structure and nutraceutical potential of β-D-glucan from barley (Hordeum vulgare). | This paper reports the characterization and potential antioxidant activity of β-D-glucan isolated from barley treated with γ-rays. The β-D-glucan was irradiated with 0, 2, 4 and 8 kGy by gamma ray. The samples were characterized by Fourier transform-infrared spectroscopy, gel permeation chromatography (GPC) and quantit... | 25,239,191 | [
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Dietary Astragalus polysaccharide alleviated immunological stress in broilers exposed to lipopolysaccharide. | This study was conducted to investigate whether dietary Astragalus polysaccharide (APS) could alleviate immunological stress response of chickens after challenge with lipopolysaccharide (LPS). A total of 360 one-day-old commercial Arbor Acres broilers were randomly assigned in a 2 × 2 factorial design. The main factors... | 25,239,195 | [
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Advances in Setaria genomics for genetic improvement of cereals and bioenergy grasses. | Recent advances in Setaria genomics appear promising for genetic improvement of cereals and biofuel crops towards providing multiple securities to the steadily increasing global population. The prominent attributes of foxtail millet (Setaria italica, cultivated) and green foxtail (S. viridis, wild) including small geno... | 25,239,219 | [
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Outcomes of fecal carriage of extended-spectrum β-lactamase after transrectal ultrasound-guided biopsy of the prostate. | To determine the prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (PE) fecal carriage in patients that undergo transrectal ultrasonography-guided biopsy (TRUSbx) and its relationship with post-biopsy infections. A prospective clinical study in 4 different tertiary hospitals between 2008 a... | 25,239,255 | [
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Comparison of geographic methods to assess travel patterns of persons diagnosed with HIV in Philadelphia: how close is close enough? | Travel distance to medical care has been assessed using a variety of geographic methods. Network analyses are less common, but may generate more accurate estimates of travel costs. We compared straight-line distances and driving distance, as well as average drive time and travel time on a public transit network for 178... | 25,239,262 | [
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Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. | Accurate and timely diagnosis of inherited bone marrow failure and inherited myelodysplastic syndromes is essential to guide clinical management. Distinguishing inherited from acquired bone marrow failure/myelodysplastic syndrome poses a significant clinical challenge. At present, diagnostic genetic testing for inherit... | 25,239,263 | [
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Is physical behavior affected in fatigued persons with multiple sclerosis? | To study physical behavior in detail in fatigued persons with multiple sclerosis (MS). Case-control explorative study. Outpatient rehabilitation department and participants' daily environment. Fatigued persons with MS (n=23) were selected from a randomized controlled trial. Cases were matched by age and sex to healthy,... | 25,239,283 | [
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Frequency and Clinical Correlates of Sleep-Related Problems Among Anxious Youth with Autism Spectrum Disorders. | Sleep-related problems (SRPs) are common and problematic among anxious youth but have not been investigated in anxious youth with autism spectrum disorder (ASD). Participants were 102 youth (ages 7-16 years) with ASD and comorbid anxiety. Youth and their primary caregiver were administered the Pediatric Anxiety Rating ... | 25,239,284 | [
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An algorithm to decompose ground reaction forces and moments from a single force platform in walking gait. | In walking experimental conditions, subjects are sometimes unable to perform two steps on two different forceplates. This leads the authors to develop methods for discerning right and left ground reaction data while they are summed during the double support in walking. The aim of this study is to propose an adaptive tr... | 25,239,287 | [
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Airway wall eosinophilia is not a feature of equine heaves. | The objective of this study was to determine whether eosinophils infiltrate the airway wall of horses with heaves. Eosinophils were evaluated using paraffin embedded lung tissues from six heaves-affected horses in crisis and six aged-matched controls. Slides were stained using Luna's method and eosinophils enumerated u... | 25,239,297 | [
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The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells. | Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type 1 (BRIC1). Apart from cholestasis, many patients also suffer from diarrhea of yet unkn... | 25,239,307 | [
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Is intraoperative parathyroid hormone monitoring necessary with ipsilateral parathyroid gland visualization during anticipated unilateral exploration for primary hyperparathyroidism: a two-institution analysis of more than 2,000 patients. | Intraoperative parathyroid hormone (ioPTH) monitoring during focused parathyroidectomy for primary hyperparathyroidism (PHPT) is used commonly, but some argue that ioPTH adds little if a normal ipsilateral parathyroid gland (IPG) is visualized. This hypothesis was tested for validity. The prospective databases of conse... | 25,239,313 | [
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Novel microRNA correlations in the severely injured. | Severe injury initiates an inflammatory response that can perpetuate immunological dysfunction, uncontrolled inflammation, and subsequent multisystem organ failure. MicroRNAs (miRNAs) have recently been identified as regulators of this inflammatory response. Our study sought to identify the differential expression of u... | 25,239,329 | [
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Outpatient follow-up versus 30-day readmission among general and vascular surgery patients: a case for redesigning transitional care. | The association between early outpatient follow-up and 30-day readmission has not been evaluated in any surgical population. Our study characterizes the relationship between outpatient follow-up and early readmissions among surgical patients. We queried the medical record at a large, tertiary care institution (July 200... | 25,239,351 | [
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Production of polyclonal antibody to a recombinant non-structural protein Nsp1a of human astrovirus. | Human astrovirus (HAstV) are important pathogens that cause acute viral diarrhea in infants. Little is known about the mechanisms of astrovirus-induced diarrhea. Previous studies have suggested that an apoptosis inducer may be encoded in the non-structural protein (nsP1a) of astrovirus and contribute to virus-induced d... | 25,239,369 | [
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Initial oxygenation response to inhaled nitric oxide predicts improved outcome in congenital diaphragmatic hernia. | Pulmonary hypertension (PH) is the most important complication of congenital diaphragmatic hernia (CDH) and still has a high mortality rate. The aim of this study was to evaluate the effectiveness of inhaled nitric oxide therapy in PH due to CDH. Hospital records of children who had undergone inhaled nitric oxide thera... | 25,239,432 | [
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Novel renal biomarkers to assess cardiorenal syndrome. | Renal dysfunction (RD) in heart failure portends adverse outcomes and often limits aggressive medical and decongestive therapies. Despite the high prevalence in this population, not all forms of RD are prognostically or mechanistically equivalent: RD can result from irreversible nephron loss secondary to diabetic or hy... | 25,239,434 | [
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Routine use of bilateral internal thoracic artery grafts for left-sided myocardial revascularization in insulin-dependent diabetic patients: early and long-term outcomes. | Despite encouraging late outcomes, the use of bilateral internal thoracic artery (BITA) grafting for myocardial revascularization in diabetic patients remains controversial because of an increased risk of sternal complications. In the present study, early and long-term outcomes of the routine use of left-sided BITA gra... | 25,239,446 | [
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BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development. | BRCA1 mutation carriers are predisposed to developing basal-like breast cancers with high metastasis and poor prognosis. Yet, how BRCA1 suppresses formation of basal-like breast cancers is still obscure. Deletion of p18(Ink4c) (p18), an inhibitor of CDK4 and CDK6, functionally inactivates the RB pathway, stimulates mam... | 25,239,453 | [
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Ribosome abundance regulates the recovery of skeletal muscle protein mass upon recuperation from postnatal undernutrition in mice. | Nutritionally-induced growth faltering in the perinatal period has been associated with reduced adult skeletal muscle mass; however, the mechanisms responsible for this are unclear. To identify the factors that determine the recuperative capacity of muscle mass, we studied offspring of FVB mouse dams fed a protein-rest... | 25,239,457 | [
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Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition. | GABA is the major inhibitory transmitter in the brain and is released not only from a subset of neurons but also from glia. Although neuronal GABA is well known to be synthesized by glutamic acid decarboxylase (GAD), the source of glial GABA is unknown. After estimating the concentration of GABA in Bergmann glia to be ... | 25,239,459 | [
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PET/CT before autologous stem cell transplantation predicts outcome in refractory/relapsed follicular lymphoma. | Salvage of young patients with follicular lymphoma (FL) after R-CHOP includes salvage immunochemotherapy followed by autologous stem cell transplantation (ASCT). Previous studies dealing with relapsed Hodgkin lymphoma have shown the prognostic value of PET/CT prior to ASCT. We retrospectively analysed 59 patients with ... | 25,239,490 | [
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Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency. | Dysfunctional stem cell differentiation into placental lineages is associated with gestational diseases. Of the differentiated lineages available to trophoblast stem cells (TSC), elevated O2 and mitochondrial function are necessary to placental lineages at the maternal-placental surface and important in the etiology of... | 25,239,494 | [
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Leukopenia predicts remission in patients with inflammatory bowel disease and Behcet's disease on thiopurine maintenance. | The thiopurine drugs, azathioprine (AZA), and 6-mercaptopurine (6-MP) are well-established drugs for the treatment of inflammatory bowel disease (IBD). Although leukopenia is a well-recognized side effect of AZA/6-MP treatment, its association with therapeutic effects has yet to be determined. We therefore evaluated th... | 25,239,495 | [
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Prevalence and genomic characterization of G2P[4] group A rotavirus strains during monovalent vaccine introduction in Brazil. | This study aims to: estimate the prevalence of G2P[4] rotaviruses in Brazil between 2001-2011 from patients with acute gastroenteritis; perform phylogenetic analyses of G2P[4] Brazilian strains (from vaccinated and non-vaccinated children) based on VP7 and VP8(∗) encoding genes and analyze the antigenic regions of thes... | 25,239,525 | [
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Association between SNPs in miRNA-machinery genes and chronic hepatitis B in the Chinese Han population. | Single nucleotide polymorphisms (SNPs) in miRNA-machinery genes can influence their generation and maturation, then expression and structure. To explore the relationship between three SNPs (rs3757 in DGCR8, rs636832 in AGO1, rs7813 in GEMIN4) in miRNA-machinery genes and chronic hepatitis B, we genotyped the SNPs by hi... | 25,239,527 | [
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Evaluation of 3 analyte-specific reagents for detection of Bordetella pertussis and Bordetella parapertussis in clinical specimens. | The performance of 3 analyte-specific reagents (ASRs), Elitech Biosciences, EraGen Biosciences, and Focus Diagnostic, was evaluated for detection of Bordetella pertussis (BP) and Bordetella parapertussis (BPP) in nasopharyngeal swab specimens. A total of 104 frozen, leftover clinical specimens obtained from pediatric p... | 25,239,539 | [
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Evaluation of two flexible colonoscopy simulators and transfer of skills into clinical practice. | Surgical residents have learned flexible endoscopy by practicing on patients in hospital settings under the strict guidance of experienced surgeons. Simulation is often used to "pretrain" novices on endoscopic skills before real clinical practice; nonetheless, the optimal method of training remains unknown. The purpose... | 25,239,553 | [
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[Obesity and the severity of asthma crisis]. | Obesity is associated with inflammatory processes, which could influence the airway inflammation that is found in patients with asthma. Obesity may thus have a role in the development of asthma. However, the role of obesity in the severity of acute asthma has not been well described. We performed a retrospective study,... | 25,239,583 | [
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[An unusual mediastinal mass]. | Primary mediastinal tumors are rare diseases including a broad spectrum of pathologies ranging from the well-known, such as lymphoma, thymoma or germ-line tumors to some very unusual presentations. We describe a solitary mediastinal mass compressing the bronchial and vascular system in a patient suffering from chronic ... | 25,239,585 | [
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Time course of motor and cognitive functions after chronic cerebral ischemia in rats. | Cerebral ischemia is one of the leading causes of death and long-term disability in aging populations, due to the frequent occurrence of irreversible brain damage and subsequent loss of neuronal function which lead to cognitive impairment and some motor dysfunction. In the present study, the real time course of motor a... | 25,239,606 | [
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Phase II study of perifosine and sorafenib dual-targeted therapy in patients with relapsed or refractory lymphoproliferative diseases. | To evaluate safety and activity of perifosine and sorafenib combination therapy in patients with lymphoproliferative diseases. Patients with relapsed and refractory lymphoproliferative diseases received perifosine (50 mg twice daily) for 1 month. Patients achieving less than partial response (PR) after perifosine alone... | 25,239,609 | [
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Validation of biomarkers that complement CA19.9 in detecting early pancreatic cancer. | Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer mortality. Carbohydrate antigen 19.9 (CA19.9), the only tumor marker available to detect and monitor PDAC, is not sufficiently sensitive and specific to consistently differentiate early cancer from benign disease. In this study, we aimed to valida... | 25,239,611 | [
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Implementation of a consent for chart review and contact and its impact in one clinical centre. | Informed consent and protection of patient confidentiality are central to the conduction of clinical research. Consent for chart review and contact (CCRC) allows a patient chart to be screened for research by persons outside the direct circle-of-care and for the patient to be contacted regarding potential studies. This... | 25,239,620 | [
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Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. | Accidents caused by scorpions represent a relevant public health issue in Brazil, being more recurring than incidents with snakes and spiders. The main species responsible for this situation is the yellow scorpion, Tityus serrulatus, due especially to the great frequency with which accidents occur and the potential of ... | 25,239,630 | [
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Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio). | Organophosphate flame retardants (OPFRs) are common replacements for the phased-out polybrominated diphenyl ethers (PBDEs) and have been detected at high concentrations in environmental samples. OPFRs are structurally similar to organophosphate pesticides and may adversely affect the developing nervous system. This stu... | 25,239,634 | [
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Predictors of senior center use among older adults in New York City public housing. | Despite agreement among stakeholders that senior centers can promote physical and mental health, research on senior center use in urban populations is limited. Our objective was to describe demographic and health factors associated with senior center use among urban, low-income older adults in order to inform programmi... | 25,239,639 | [
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A comparison between respondent-driven sampling and time-location sampling among men who have sex with men in Shenzhen, China. | Men who have sex with men (MSM) are a key population for HIV control and prevention in China. It is difficult to acquire representative samples of this hidden population. Respondent-driven sampling (RDS), based on peer referral, and time-location sampling (TLS) based on random selection of venue-day-time periods, are a... | 25,239,658 | [
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Induction and imaging of photothrombotic stroke in conscious and freely moving rats. | In experimental stroke research, anesthesia is common and serves as a major reason for translational failure. Real-time cerebral blood flow (CBF) monitoring during stroke onset can provide important information for the prediction of brain injury; however, this is difficult to achieve in clinical practice due to various... | 25,239,673 | [
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Intramural hematoma of the esophagus after thrombolysis for ischemic stroke. | Intramural dissecting hematoma is an unusual esophageal condition with a threatening presentation but excellent prognosis when managed conservatively.We report the case of an 88-year-old woman who developed an intramural hematoma of the esophagus after intravenous thrombolysis for an acute ischemic stroke. Before throm... | 25,239,697 | [
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The "sweet" side of ion channels. | Ion channels play a crucial role in cell functioning, contributing to transmembrane potential and participating in cell signalling and homeostasis. To fulfil highly specialised functions, cells have developed various mechanisms to regulate channel expression and activity at particular subcellular loci, and alteration o... | 25,239,698 | [
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Three-column intermittent simulated moving bed chromatography: 2. Experimental implementation for the separation of Tröger's Base. | The three-column intermittent simulated moving bed (3C-ISMB) process has been presented in the first part of this series [1]. A theoretical comparative analysis of the new process to intermittent simulated moving bed (I-SMB) demonstrated successfully the potential of the 3C-ISMB technology. Particularly, 3C-ISMB was sh... | 25,239,701 | [
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Reducing healthcare-associated infections in an ambulatory dialysis unit: Identification and alignment of work system factors. | Patients undergoing hemodialysis have experienced a 43% increase in rate of hospitalization due to infection during the past 20 years. Research in other industries has shown that safe systems are achieved by considering the entire system to enable performance specifications to be met. A sociotechnical systems framework... | 25,239,723 | [
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Recombineering linear BACs. | Recombineering is a powerful genetic engineering technique based on homologous recombination that can be used to accurately modify DNA independent of its sequence or size. One novel application of recombineering is the assembly of linear BACs in E. coli that can replicate autonomously as linear plasmids. A circular BAC... | 25,239,740 | [
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Herpesvirus mutagenesis facilitated by infectious bacterial artificial chromosomes (iBACs). | A critical factor in the study of herpesviruses, their genes and gene functions is the capacity to derive mutants that harbor deletions, truncations, or insertions within the genetic elements of interest. Once constructed the impact of the introduced mutation on the phenotypic properties of the rescued virus can be det... | 25,239,746 | [
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Deviations of inorganic and organic carbon content in hypomineralised enamel. | The purpose of this study was to discriminate hypomineralised enamel of permanent first molars from normal enamel by means of spectroscopic methods. The present study was conducted using Multi spot Raman Fourier Transform Spectroscopy, Diffuse Reflectance Infrared Fourier Transform Spectroscopy (FTIR) and X-ray diffrac... | 25,239,769 | [
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Tilted versus axially placed dental implants: a meta-analysis. | The purpose of the present review was to test the null hypothesis of no difference in the implant failure rate, marginal bone loss, and postoperative infection for patients being rehabilitated by tilted or by axially placed dental implants, against the alternative hypothesis of a difference. An electronic search withou... | 25,239,770 | [
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Late surgical repair of a traumatic ventricular septal defect. | Ventricular Septal Defect (VSD) complicates approximately 1-5% of patients presenting with penetrating chest trauma, however not all VSDs are evident at the time of initial presentation to the emergency department. Acute closure of traumatic VSDs is indicated in patients with a large defect and haemodynamic compromise,... | 25,239,775 | [
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0.03037665,
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0.052441,
0.3484406,
0.07312336,... |
Long-term urine biobanking: storage stability of clinical chemical parameters under moderate freezing conditions without use of preservatives. | To examine the long-term stability and validity of analyte concentrations of 21 clinical biochemistry parameters in 24-h urine samples stored for 12 or 15 yr at -22°C and preservative free. Healthy children's 24-h urine samples in which the respective analytes had been measured shortly after sample collection (baseline... | 25,239,781 | [
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Production, separation and applications of phenolic-rich bio-oil--a review. | This paper provides an overview of current research trends in the production and separation of phenolic-rich bio-oils, as well as their applications. The first part of this paper highlights the strong dependency of the phenolic content of bio-oil on the kinds of biomass feedstock, reaction system, reaction conditions, ... | 25,239,785 | [
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β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men. | Patients with coronary artery disease have attenuated coronary vasodilator responses to physiological stress, which is partially attributed to a β-adrenergic receptor (β-AR)-mediated mechanisms. Whether β-ARs contribute to impaired coronary vasodilation seen with healthy aging is unknown. The purpose of this study was ... | 25,239,806 | [
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0.030... |
Evaluation of anti-HIV-1 activity of a new iridoid glycoside isolated from Avicenna marina, in vitro. | This study was carried out to check the efficacy of methanol seed extract of Avicenna marina and its column chromatographic fractions on Peripheral Blood Mono nuclear Cells (PBMCs) toxicity and HIV-1 replication. The anti-HIV-1 activities of crude methanol extract and its fractions were performed by use of real-time po... | 25,239,814 | [
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Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein. | Cyclic di-AMP (c-di-AMP) is a recently recognized bacterial signaling molecule. In this study, a competitive enzyme-linked immunosorbent assay (ELISA) for the quantification of c-di-AMP was developed using a novel pneumococcal c-di-AMP binding protein (CabP). With this method, c-di-AMP concentrations in biological samp... | 25,239,824 | [
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... |
In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor. | Inhibiting angiogenesis is a major approach in tumour therapy. To combat angiogenesis, the tubulin cytoskeleton has emerged as an interesting target in many pre- and clinical studies. Contrarily, the actin cytoskeleton has been largely neglected as a potential drug target in angiogenesis. However, due to the developmen... | 25,239,826 | [
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Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium. | Vascular aging is accompanied by increases in circulatory proinflammatory cytokines leading to inflammatory endothelial response implicated in early atherogenesis. To study the possible role of mitochondria-derived reactive oxygen species (ROS) in this phenomenon, we applied the effective mitochondria-targeted antioxid... | 25,239,871 | [
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0.1039924,
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hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling. | Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent member of the transforming growth factor beta (TGF-β) superfamily and mice expressing hNAG-1/hGDF15 have been shown to be resistant to HFD-induced obesity and inflammation. This study investigated if hNAG-1 increases lifespan in mice and... | 25,239,873 | [
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0.324075,
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0.1927184,
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The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA. | There is now a general consensus that RA has a spectrum of disease stages that can begin many years before the onset of clinical symptoms. It is widely thought that understanding the complex interplay between genetics and environment, and their role in pathogenesis, is essential in gaining further insight into the mech... | 25,239,882 | [
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0.1529814,
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0.2569707,
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GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury. | Although AMP-activated protein kinase (AMPK) is involved in regulating carbohydrate and lipid metabolism, activated AMPK also plays an anti-inflammatory role in many cell populations. However, despite the ability of AMPK activation to diminish the severity of inflammatory responses, previous studies have found that AMP... | 25,239,914 | [
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Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells. | Local Ca(2+) signals (Ca(2+) sparks) play an important role in multiple cellular functions in airway smooth muscle cells (ASMCs). Protein kinase Cϵ is known to downregulate ASMC Ca(2+) sparks and contraction; however, no complementary phosphatase has been shown to produce opposite effects. Here, we for the first time r... | 25,239,916 | [
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0.1464515... |
Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. | The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact rodents are of limited value for this ... | 25,239,917 | [
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Rac1--a novel regulator of contraction-stimulated glucose uptake in skeletal muscle. | Muscle contraction stimulates muscle glucose uptake by facilitating translocation of glucose transporter 4 from intracellular locations to the cell surface, which allows for diffusion of glucose into the myofibres. The intracellular mechanisms regulating this process are not well understood. The GTPase Rac1 has, until ... | 25,239,922 | [
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In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cells. | Interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib were examined in non-Hodgkin lymphoma (NHL) models, including diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and double-hit lymphoma cells. Marked in vitro synergism was observed in ... | 25,239,935 | [
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0.0550192,
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0.07016... |
Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. | The RG7787 mesothelin-targeted recombinant immunotoxin (RIT) consists of an antibody fragment targeting mesothelin (MSLN) fused to a 24-kD fragment of Pseudomonas exotoxin A for cell killing. Compared with prior RITs, RG7787 has improved properties for clinical development including decreased nonspecific toxicity and i... | 25,239,937 | [
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... |
The prevalence of loneliness among U.S. Chinese older adults. | Loneliness is an important indicator of well-being. However, we have limited understanding of loneliness in minority aging populations. This study aims to identify the prevalence of loneliness among U.S. Chinese older adults. Data were drawn from the PINE study, a population-based study of 3,159 U.S. Chinese older adul... | 25,239,972 | [
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0.4284038,
0.0275810... |
Hemorrhagic collision metastasis in a cerebral arteriovenous malformation. | A 26-year-old patient with recurrent choriocarcinoma of the testis presented with headache and progressive left homonymous hemianopsia. On initial MRI a grade 4 arteriovenous malformation (AVM) was identified in the right occipital lobe, which was further characterized by catheter angiography. Continued worsening of th... | 25,239,982 | [
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Central alarin ameliorated insulin resistance of adipocytes in type 2 diabetic rats. | Alarin, a regulatory peptide, belongs to the galanin family and plays the same regulatory roles as galanin in orexigenic activity and energy metabolism. Our previous studies had found that galanin might facilitate insulin sensitivity via activation of its central receptors. To date, little is known about whether centra... | 25,240,061 | [
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Derivation and validation of simple equations to predict total muscle mass from simple anthropometric and demographic data. | Muscle mass reflects and influences health status. Its reliable estimation would be of value for epidemiology. The aim of the study was to derive and validate anthropometric prediction equations to quantify whole-body skeletal muscle mass (SM) in adults. The derivation sample included 423 subjects (227 women) aged 18-8... | 25,240,071 | [
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Added sugars and periodontal disease in young adults: an analysis of NHANES III data. | Added sugar consumption seems to trigger a hyperinflammatory state and may result in visceral adiposity, dyslipidemia, and insulin resistance. These conditions are risk factors for periodontal disease. However, the role of sugar intake in the cause of periodontal disease has not been adequately studied. We evaluated th... | 25,240,081 | [
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Thromboembolism incidence and prophylaxis during vaginal delivery hospitalizations. | Although major international guidelines recommend venous thromboembolism (VTE) prophylaxis during vaginal delivery hospitalization for women with additional risk factors, US guidelines recommend prophylaxis for a very small number of women who are at particularly high risk for an event. The purpose of this study was to... | 25,240,092 | [
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0.1741... |
Design, synthesis and antimycobacterial activity of various 3-(4-(substitutedsulfonyl)piperazin-1-yl)benzo[d]isoxazole derivatives. | In this communication, we synthesized a series of twenty four novel 3-(4-(substitutedsulfonyl)piperazin-1-yl)benzo[d]isoxazole analogues, characterized using various spectroscopic techniques and evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis (MTB) H37Rv strain. The titled compo... | 25,240,097 | [
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0.4143601,
0.15804,
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0.1484... |
A controlled trial of transcutaneous vagus nerve stimulation for the treatment of pharmacoresistant epilepsy. | This study explored the efficacy and safety of transcutaneous vagus nerve stimulation (t-VNS) in patients with pharmacoresistant epilepsy. A total of 60 patients were randomly divided into two groups based on the stimulation zone: the Ramsay-Hunt zone (treatment group) and the earlobe (control group). Before and after ... | 25,240,121 | [
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Improving the mental health of adolescents with epilepsy through a group cognitive behavioral therapy program. | The threat of unpredictable seizures makes epilepsy unique among childhood chronic illnesses. One consequence is that people who have childhood-onset epilepsy often have poor social adjustment and competence in adulthood. Better emotional and social functioning could improve long-term outcomes. Thirty-four adolescents ... | 25,240,125 | [
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Highly selective colorimetric detection and estimation of Hg2+ at nano-molar concentration by silver nanoparticles in the presence of glutathione. | The present study investigated the colorimetric detection of mercury (Hg(2+)) ions by using silver nanoparticles (Ag NPs) in the presence of glutathione. The nanoparticles used in the study were synthesized biologically by using Polyalthia longifolia leaf extract. The synthesized nanoparticles were characterized by UV-... | 25,240,142 | [
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Pollinia-borne chemicals that induce early postpollination effects in Dendrobium flowers move rapidly into agar blocks and include ACC and compounds with auxin activity. | The early visible effects of pollination in orchids are likely due to pollinia-borne chemicals. In Dendrobium we tested whether such compounds were water soluble and would diffuse in solid-aqueous phase, and determined both 1-aminocyclopropane-1-carboxylic acid (ACC) concentrations and auxin activity. Following pollina... | 25,240,156 | [
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Impact of preoperative serum creatinine on short- and long-term mortality after cardiac surgery: a cohort study. | Preoperative renal insufficiency is an important predictor of mortality after cardiac surgery. This retrospective cohort study was designed to identify the optimal cut-off for baseline serum creatinine (bSCr) and estimated glomerular filtration rate (eGFR) to predict survival. Furthermore, we investigated the potential... | 25,240,162 | [
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0.... |
A convenient synthesis of novel aza-C-disaccharide analogues. | Novel aza-C-disaccharide analogues have been conveniently synthesized by using the isoxazoline-linked C-disaccharide derivatives as the intermediates. Firstly, the C=N of isoxazoline was reduced to C-N by using DIBAL-H as reducing agent, then followed by the tandem multi-step reactions through catalytic hydrogenation w... | 25,240,179 | [
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0.116638,
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0.1645005,
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0.07006397,
0.04994199,
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0.2576162,
0.1801419,
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Assessment of floating plastic debris in surface water along the Seine River. | This study is intended to examine the quality and quantity of floating plastic debris in the River Seine through use of an extensive regional network of floating debris-retention booms; it is one of the first attempts to provide reliable information on such debris at a large regional scale. Plastic debris represented b... | 25,240,189 | [
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0.2914982,
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-... |
Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke. | Molecular chaperones are required for successful folding and assembly of sarcomeric myosin in skeletal and cardiac muscle. Here, we show that the chaperone UNC-45B inhibits the actin translocation function of myosin. Further, we show that Hsp90, another chaperone involved in sarcomere development, allows the myosin to ... | 25,240,199 | [
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0.04574302,
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0.5644644,
0.147288,
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0.... |
Development and validation of bioanalytical method for simultaneous estimation of ramipril and hydrochlorothiazide in human plasma using liquid chromatography-tandem mass spectrometry. | The present study describes a novel liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the simultaneous estimation of ramipril (RAM) and hydrochlorothiazide (HCTZ) in human plasma using liquid-liquid extraction technique. This method made use of electrospray ionization in positive mode for RAM and i... | 25,240,204 | [
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0.5002658,
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0.07098144,
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0.05299539,
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Routine use of ultrasound-guided access reduces access site-related complications after lower extremity percutaneous revascularization. | We sought to elucidate the risks for access site-related complications (ASCs) after percutaneous lower extremity revascularization and to evaluate the benefit of routine ultrasound-guided access (RUS) in decreasing ASCs. We reviewed all consecutive percutaneous revascularizations (percutaneous transluminal angioplasty ... | 25,240,244 | [
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Dissociation of functional and anatomical brain abnormalities in unaffected siblings of schizophrenia patients. | Schizophrenia patients and their unaffected siblings share similar brain functional and structural abnormalities. However, no study is engaged to investigate whether and how functional abnormalities are related to structural abnormalities in unaffected siblings. This study was undertaken to examine the association betw... | 25,240,248 | [
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0.01242511,
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0.1212188,
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0.2175084,
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Integrating monitor alarms with laboratory test results to enhance patient deterioration prediction. | Patient monitors in modern hospitals have become ubiquitous but they generate an excessive number of false alarms causing alarm fatigue. Our previous work showed that combinations of frequently co-occurring monitor alarms, called SuperAlarm patterns, were capable of predicting in-hospital code blue events at a lower al... | 25,240,252 | [
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The clinician in the Driver's Seat: part 1 - a drag/drop user-composable electronic health record platform. | Creating electronic health records that support the uniquely complex and varied needs of healthcare presents formidable challenges. To address some of these challenges we created a new model for healthcare information systems, embodied in MedWISE,(2) a widget-based highly configurable electronic health record (EHR) pla... | 25,240,253 | [
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0.2756107,
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0.0115684,
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Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. | Highly toxic organophosphorus (OP) nerve agents are well characterized regarding chemical, biological and toxicological properties and the effectiveness of standard atropine and oxime therapy. Open literature data on the key nerve agent precursor methylphosphonic difluoride (DF) are scarce. To fill this gap the reactio... | 25,240,274 | [
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0.1517342,
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0.5118642,
0.1402746,
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... |
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. | Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1 associated) or after radiotherapy. Using comprehensive genomic approaches, we identified loss-of-function somatic alterations of th... | 25,240,281 | [
-0.02394164,
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0.06960832,
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0.06555644,
0.05514644,
0.1116782,
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Alterations in the nuclear proteome of HIV-1 infected T-cells. | Virus infection of a cell involves the appropriation of host factors and the innate defensive response of the cell. The identification of proteins critical for virus replication may lead to the development of novel, cell-based inhibitors. In this study we mapped the changes in T-cell nuclei during human immunodeficienc... | 25,240,327 | [
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0.05535613,
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0.04384788,
0.1867704,
0.4484958,
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... |
Intranasal immunization with DNA vaccine coexpressing Der p 1 and ubiquitin in an allergic rhinitis mouse model. | The worldwide prevalence of allergic rhinitis (AR) is increasing, whereas treatments for AR remain limited in effect. Therefore, a new type of effective drug is eagerly in demand. To create a hypoallergenic vaccine by forced ubiquitination. In the present study, we constructed a DNA vaccine coexpressing Der p 1 allerge... | 25,240,330 | [
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... |
A general time-dependent route to resonance-Raman spectroscopy including Franck-Condon, Herzberg-Teller and Duschinsky effects. | We present a new formulation of the time-dependent theory of Resonance-Raman spectroscopy (TD-RR). Particular attention has been devoted to the generality of the framework and to the possibility of including different effects (Duschinsky mixing, Herzberg-Teller contributions). Furthermore, the effects of different harm... | 25,240,346 | [
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Dielectric-dependent screened Hartree-Fock exchange potential and Slater-formula with Coulomb-hole interaction for energy band structure calculations. | We previously reported a screened Hartree-Fock (HF) exchange potential for energy band structure calculations [T. Shimazaki and Y. Asai, J. Chem. Phys. 130, 164702 (2009); T. Shimazaki and Y. Asai, J. Chem. Phys. 132, 224105 (2010)]. In this paper, we discuss the Coulomb-hole (COH) interaction and screened Slater-formu... | 25,240,347 | [
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0.03847479,
0.2053462,
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0.... |
Test of the interaction potential energy for Na⁺-H₂ by gaseous ion transport data. | Transport properties of Na(+) ions in gaseous hydrogen are calculated using the recently developed "beyond Monchick-Mason" (BMM) approximation and an ab initio Na(+)-H2 potential energy surface. Good agreement with the experimental data on the reduced mobility and longitudinal diffusion coefficient proves the accuracy ... | 25,240,356 | [
-0.2751003,
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0.02811626,
0.1080572,
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0.066598... |
Topological defects around a spherical nanoparticle in nematic liquid crystal: coarse-grained molecular dynamics simulations. | We consider the applicability of coarse-grained molecular dynamics for the simulation of defects in a nematic liquid crystal around a colloidal particle. Two types of colloids are considered, a soft colloid resembling a liquid crystal dendrimer or a similar macromolecule. In addition, a decorated colloid is used which ... | 25,240,368 | [
0.06150392,
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0.1007578,
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0.2827063,
0.06232534,
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Bionomic response of Aedes aegypti to two future climate change scenarios in far north Queensland, Australia: implications for dengue outbreaks. | Dengue viruses are transmitted by anthropophilic mosquitoes and infect approximately 50 million humans annually. To investigate impacts of future climate change on dengue virus transmission, we investigated bionomics of the mosquito vector, Aedes aegypti. Using a dynamic life table simulation model (the Container inhab... | 25,240,382 | [
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0.07039835,
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0.5012857,
0.01140975,... |
Low-level laser therapy as an alternative for pulpotomy in human primary teeth. | This study aimed to evaluate the effects of low-level laser therapy (LLLT) on pulpal response of primary teeth. Twenty mandibular primary molars were randomly divided into the following groups: group I Buckley's formocresol (diluted at 1:5), group II calcium hydroxide, group III LLLT + zinc oxide/eugenol, and group IV ... | 25,240,388 | [
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0.0661625,
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0.1122323,
0.09549376,
0.1847849,
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