title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Organisational space for partnership and sustainability: lessons from the implementation of the National Dementia Strategy for England. | National policy initiatives are faced with challenges in their partnership development and sustainability. The National Dementia Strategy for England recommended Dementia Adviser (DA) and Peer Support Network (PSN) services and 40 demonstration sites were established. In this paper, we report on the national evaluation... | 25,243,927 | [
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Aquaporin expression profiles in normal sinonasal mucosa and chronic rhinosinusitis. | Thickened secretions, mucosal edema, and polyp formation are pathological features in chronic rhinosinusitis (CRS) that could theoretically be caused by aberrant water flow through sinonasal mucosa. Aquaporins (AQPs) are a family of proteins with roles in water transport, with tissue-specific expression profiles. This ... | 25,243,928 | [
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Silicon nanohybrid-based surface-enhanced Raman scattering sensors. | Nanomaterial-based surface-enhanced Raman scattering (SERS) sensors are highly promising analytical tools, capable of ultrasensitive, multiplex, and nondestructive detection of chemical and biological species. Extensive efforts have been made to design various silicon nanohybrid-based SERS substrates such as gold/silve... | 25,243,935 | [
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The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing. | Peripheral myelin protein 22 (PMP22) is a tetraspan membrane protein strongly expressed in myelinating Schwann cells of the peripheral nervous system. Myriad missense mutations in PMP22 result in varying degrees of peripheral neuropathy. We used Rosetta 3.5 to generate a homology model of PMP22 based on the recently pu... | 25,243,937 | [
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Primary pancreatic choriocarcinoma revealed on FDG PET/CT. | Choriocarcinoma is a cancer that usually occurs in the uterus during pregnancy. Extragonadal choriocarcinoma, although very rare, can occur. The diagnostic dilatation and curettage of the uterus in a 28-year-old woman who had vaginal bleeding and elevated human chorionic gonadotrophin level failed to identify any abnor... | 25,243,947 | [
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Total synthesis of (+)-18-epi-latrunculol A: development of a synthetic route. | The evolution of an enantioselective total synthesis of (+)-18-epi-latrunculol A, a congener of the marine-sponge-derived latrunculins A and B, is reported. Key steps include a late-stage Mitsunobu macrolactonization to construct the 16-membered macrolactone, a mild Carreira alkynylation to unite the northern and south... | 25,243,951 | [
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Evaluating tablet computers as a survey tool in rural communities. | Although tablet computers offer advantages in data collection over traditional paper-and-pencil methods, little research has examined whether the 2 formats yield similar responses, especially with underserved populations. We compared the 2 survey formats and tested whether participants' responses to common health quest... | 25,243,953 | [
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Pelvic examination experiences in women with and without chronic pain during intercourse. | Although pelvic examinations (PEs) are an important component of women's health, some women experience difficulty during PEs due to anxiety and pain. These difficulties may be heightened in women with chronic pain during sexual intercourse. Some evidence suggests that this population experiences pain and distress durin... | 25,243,968 | [
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Anterior thigh composition measured using ultrasound imaging to quantify relative thickness of muscle and non-contractile tissue: a potential biomarker for musculoskeletal health. | This study aimed to use ultrasound imaging to provide objective data on the effects of ageing and gender on relative thickness of quadriceps muscle and non-contractile tissue thickness (subcutaneous fat, SF, combined with perimuscular fascia). In 136 healthy males and females (aged 18-90 years n = 63 aged 18-35 years; ... | 25,243,984 | [
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Deactivation of 6-aminocoumarin intramolecular charge transfer excited state through hydrogen bonding. | This paper presents results of the spectral (absorption and emission) and photophysical study of 6-aminocoumarin (6AC) in various aprotic hydrogen-bond forming solvents. It was established that solvent polarity as well as hydrogen-bonding ability influence solute properties. The hydrogen-bonding interactions between S1... | 25,244,014 | [
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Pesticide concentrations in frog tissue and wetland habitats in a landscape dominated by agriculture. | Habitat loss and exposure to pesticides are likely primary factors contributing to amphibian decline in agricultural landscapes. Conservation efforts have attempted to restore wetlands lost through landscape modifications to reduce contaminant loads in surface waters and providing quality habitat to wildlife. The benef... | 25,244,036 | [
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Manual liquid culture on simple Middlebrook 7H9 or MGIT for the diagnosis of smear-negative pulmonary tuberculosis. | To compare the performance of liquid culture on simple Middlebrook 7H9 to the one of manual mycobacterial growth indicator tube (MGIT) and solid culture on Ogawa for the diagnosis of smear-negative tuberculosis (SN-TB) in a high-burden, resource-constrained setting. Sputum samples from patients with clinical suspicion ... | 25,244,047 | [
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Is hypertension an autoimmune disease? | T cells are required for significant blood pressure elevation in mouse models of hypertension. Recent evidence suggests that the treatments that raise blood pressure in these animal models also cause oxidation within DCs, resulting in formation of isoketal adducts of self-proteins, which activate antigen-presenting fun... | 25,244,091 | [
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Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. | Genome-wide association studies (GWAS) have linked genes encoding several soluble NSF attachment protein receptor (SNARE) regulators to cardiovascular disease risk factors. Because these regulatory proteins may directly affect platelet secretion, we used SNARE-containing complexes to affinity purify potential regulator... | 25,244,094 | [
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Inferior parietal lobule contributions to visual word recognition. | This study investigated how the left inferior parietal lobule (IPL) contributes to visual word recognition. We used repetitive TMS to temporarily disrupt neural information processing in two anatomical fields of the IPL, namely, the angular (ANG) and supramarginal (SMG) gyri, and observed the effects on reading tasks t... | 25,244,114 | [
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Modulation of alpha activity in the parieto-occipital area by distractors during a visuospatial working memory task: a magnetoencephalographic study. | Oscillatory brain activity is known to play an essential role in information processing in working memory. Recent studies have indicated that alpha activity (8-13 Hz) in the parieto-occipital area is strongly modulated in working memory tasks. However, the function of alpha activity in working memory is open to several... | 25,244,117 | [
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Phase transition thermodynamics of bisphenols. | Herein we have studied, presented, and analyzed the phase equilibria thermodynamics of a bisphenols (BP-A, BP-E, BP-F, BP-AP, and BP-S) series. In particular, the heat capacities, melting temperatures, and vapor pressures at different temperatures as well as the standard enthalpies, entropies, and Gibbs energies of pha... | 25,244,127 | [
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Assessing total and volatile solids in municipal solid waste samples. | Municipal solid waste is broadly generated in everyday activities and its treatment is a global challenge. Total solids (TS) and volatile solids (VS) are typical control parameters measured in biological treatments. In this study, the TS and VS were determined using the standard methods, as well as introducing some var... | 25,244,131 | [
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Chemical stabilization of metals in mine wastes by transformed red mud and other iron compounds: laboratory tests. | A series of static and kinetic laboratory-scale tests were designed in order to evaluate the efficacy of transformed red mud (TRM) from bauxite refining residues, commercial zero-valent iron, and synthetic iron (III) hydroxides as sorbents/reagents to minimize the generation of acid drainage and the release of toxic el... | 25,244,134 | [
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Parameters and kinetics of olive mill wastewater dephenolization by immobilized Rhodotorula glutinis cells. | Olive mill wastewater (OMW) with total phenol (TP) concentration range of 300-1200 mg/L was treated with alginate-immobilized Rhodotorula glutinis cells in batch system. The effects of pellet properties (diameter, alginate concentration and cell loading (CL)) and operational parameters (initial TP concentration, agitat... | 25,244,135 | [
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Perceptual fluency and judgments of vocal aesthetics and stereotypicality. | Research has shown that processing dynamics on the perceiver's end determine aesthetic pleasure. Specifically, typical objects, which are processed more fluently, are perceived as more attractive. We extend this notion of perceptual fluency to judgments of vocal aesthetics. Vocal attractiveness has traditionally been e... | 25,244,150 | [
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Connecting prognostic ligand receptor signaling loops in advanced ovarian cancer. | Understanding cancer cell signal transduction is a promising lead for uncovering therapeutic targets and building treatment-specific markers for epithelial ovarian cancer. To brodaly assay the many known transmembrane receptor systems, previous studies have employed gene expression data measured on high-throughput micr... | 25,244,152 | [
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Artificial accelerators of the molecular chaperone Hsp90 facilitate rate-limiting conformational transitions. | The molecular chaperone Hsp90 undergoes an ATP-driven cycle of conformational changes in which large structural rearrangements precede ATP hydrolysis. Well-established small-molecule inhibitors of Hsp90 compete with ATP-binding. We wondered whether compounds exist that can accelerate the conformational cycle. In a FRET... | 25,244,159 | [
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Increasing use of non-traditional vehicles for psoriasis and other inflammatory skin conditions. | Although topical corticosteroid ointments were once viewed as the best vehicle for treating inflammatory skin diseases, the recognition of the problem of poor compliance and patients' preferences for other vehicles has led to the development of corticosteroid products in alternative formulations. To describe patterns o... | 25,244,174 | [
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Bladder base tenderness in the etiology of deep dyspareunia. | Bladder base tenderness can be present on pelvic exam in women with pelvic pain. However, its exact prevalence and clinical implications are not well understood. The aim of this study was to determine whether bladder base tenderness is associated with specific symptoms or signs in women, particularly dyspareunia. Retro... | 25,244,182 | [
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Ultrahigh energy density realized by a single-layer β-Co(OH)2 all-solid-state asymmetric supercapacitor. | A conceptually new all-solid-state asymmetric supercapacitor based on atomically thin sheets is presented which offers the opportunity to optimize supercapacitor properties on an atomic level. As a prototype, β-Co(OH)2 single layers with five-atoms layer thickness were synthesized through an oriented-attachment strateg... | 25,244,183 | [
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Patients with chronic pain and dysphagia (CPD): unmet medical needs and pharmacologic treatment options. | For properly selected patients experiencing chronic pain, extended-release opioid formulations may represent an appropriate pain management choice. For the many adults, elderly, and children who have medical conditions that make swallowing solid, oral-dose formulations difficult (dysphagia) or painful (odynophagia), th... | 25,244,248 | [
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Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus/acquired immune deficiency syndrome: a randomized controlled trial. | Despite the significant positive effect of Highly Active Antiretroviral Therapy on physical and psychosocial well-being of people living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) (PLWHA); decreased physical activity and its associated cardiovascular risk still pose some consequenc... | 25,244,260 | [
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... |
Impact of some low-cost interventions on students' performance in a Nigerian medical school. | Students' poor performance in physiology examinations has been worrisome to the university community. Reported preference of peer-tutoring to didactic lectures at the University of Nigeria Medical School has not been investigated. The aim of this work is to design/implement low-cost interventions to improve teaching an... | 25,244,262 | [
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A clinico-pathologic review of 56 cases of ossifying fibroma of the jaws with emphasis on the histomorphologic variations. | This study aims at contributing to the definitive diagnosis of ossifying fibroma (OF) based on histomorphological features. The study also aims to determine some demographic features of OF, common sites of occurrence and to determine whether behavior correlates well with the histomorphological variations seen in the le... | 25,244,274 | [
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Palatal rugae as a tool for human identification. | This study was conducted to assess the accuracy of palatal rugae as a tool for human identification and to determine factors that may limit accuracy. This will serve as a potential basis for advising national health policy formulation on human identification as forensic rugoscopy is unexplored in sub-Saharan Africa. On... | 25,244,278 | [
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Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells. | The use of electronic cigarettes (e-cigarettes) is rapidly increasing in the United States, especially among young people since e-cigarettes have been perceived as a safer alternative to conventional tobacco cigarettes. However, the scientific evidence regarding the human health effects of e-cigarettes on the lung is e... | 25,244,293 | [
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Quantitative determination of zopiclone and its impurity by four different spectrophotometric methods. | Four simple, sensitive and selective spectrophotometric methods are presented for determination of Zopiclone (ZPC) and its impurity, one of its degradation products, namely; 2-amino-5-chloropyridine (ACP). Method A is a dual wavelength spectrophotometry; where two wavelengths (252 and 301 nm for ZPC, and 238 and 261 nm... | 25,244,295 | [
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DNA cleavage, antibacterial, antifungal and anthelmintic studies of Co(II), Ni(II) and Cu(II) complexes of coumarin Schiff bases: synthesis and spectral approach. | The metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-toluidine/3-aminobenzotrifluoride. The synthesized Schiff bases and their metal complexes were structurally characterized based on IR, (1)H NMR, (13)C NMR, UV-visible, ESR, magnetic, thermal, fluor... | 25,244,297 | [
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0.17006... |
The long-term adaptation of bacterial communities in metal-contaminated sediments: a metaproteogenomic study. | The aim of the study was to understand the effect of a long-term metal exposure (110 years) on sediment microbial communities. Two freshwater sites, Férin and MetalEurop, differing by one order of magnitude in metal levels (MetalEurop: 3218 mg Zn kg(-1) ; 913 mg Pb kg(-1) ) were compared by shotgun metaproteogenomics. ... | 25,244,307 | [
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Hybrid data acquisition and processing strategies with increased throughput and selectivity: pSMART analysis for global qualitative and quantitative analysis. | Data-dependent acquisition (DDA) and data-independent acquisition strategies (DIA) have both resulted in improved understanding of proteomics samples. Both strategies have advantages and disadvantages that are well-published, where DDA is typically applied for deep discovery and DIA may be used to create sample records... | 25,244,318 | [
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New insights into electronic and geometric effects in the enhanced photoelectrooxidation of ethanol Using ZnO nanorod/ultrathin Au nanowire hybrids. | Oxidation of small organic molecules in a fuel cell is a viable method for energy production. However, the key issue is the development of suitable catalysts that exhibit high efficiencies and remain stable during operation. Here, we demonstrate that amine-modified ZnO nanorods on which ultrathin Au nanowires are grown... | 25,244,319 | [
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Calcifying fibrous tumor: an unrecognized IgG4--related disease? | Calcifying fibrous tumor is a rare benign mass lesion characterized by bland spindle cells embedded in abundant collagenous matrix, interspersed dystrophic or psammomatous calcifications, and lymphoplasmacytic infiltrate. It shares several clinical and morphologic features with IgG4-related disease, a newly recognized ... | 25,244,325 | [
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BPAG1a and b associate with EB1 and EB3 and modulate vesicular transport, Golgi apparatus structure, and cell migration in C2.7 myoblasts. | BPAG1a and BPAG1b (BPAG1a/b) constitute two major isoforms encoded by the dystonin (Dst) gene and show homology with MACF1a and MACF1b. These proteins are members of the plakin family, giant multi-modular proteins able to connect the intermediate filament, microtubule and microfilament cytoskeletal networks with each o... | 25,244,344 | [
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Dry powder formulation of simvastatin. | This study focuses on the development of a dry powder inhaler (DPI) formulation of simvastatin (SV), and the effects of SV on the respiratory epithelium. Micronised SV samples were prepared by dry jet-milling. The long-term chemical stability and physicochemical properties of the formulations were characterised in term... | 25,244,365 | [
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Modelling the time evolution of active caspase-3 protein in the rat lens after in vivo exposure to ultraviolet radiation-B. | To introduce a model for the time evolution of active caspase-3 protein expression in albino rat lens up to 24 hours after in vivo exposure to low dose UVR in the 300 nm wavelength region (UVR-300 nm). Forty Sprague-Dawley rats were unilaterally exposed in vivo to 1 kJ/m2 UVR-300 nm for 15 minutes. At 0.5, 8, 16, and 2... | 25,244,366 | [
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Coordination of chemical (trimethylamine oxide) and molecular (heat shock protein 70) chaperone responses to heat stress in elasmobranch red blood cells. | Chemical and molecular chaperones are organic compounds that protect and stabilize proteins from damage and aggregation as a result of cellular stress. Using the dogfish (Squalus acanthias) red blood cell (RBC) as a model, we examined whether elasmobranch cells with naturally high concentrations of the chemical chapero... | 25,244,377 | [
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... |
Mass spectrometry and imaging analysis of nanoparticle-containing vesicles provide a mechanistic insight into cellular trafficking. | Rational design of nanocarriers for drug delivery approaches requires an unbiased knowledge of uptake mechanisms and intracellular trafficking pathways. Here we dissected these processes using a quantitative proteomics approach. We isolated intracellular vesicles containing superparamagnetic iron oxide polystyrene nano... | 25,244,389 | [
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Posttreatment motivation and alcohol treatment outcome 9 months later: findings from structural equation modeling. | To investigate the association between posttreatment motivation to change as measured by the Readiness to Change Questionnaire Treatment Version and drinking outcomes 9 months after the conclusion of treatment for alcohol problems. Data from 392 participants in the United Kingdom Alcohol Treatment Trial were used to fi... | 25,244,390 | [
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Gatifloxacin 0.5% administered twice daily for the treatment of acute bacterial conjunctivitis in patients one year of age or older. | To evaluate the efficacy and safety of gatifloxacin 0.5% ophthalmic solution administered twice daily for treatment of acute bacterial conjunctivitis. Two identically designed, double-masked, multicenter studies in the United States and India enrolled patients 1 year or older with acute bacterial conjunctivitis. Patien... | 25,244,402 | [
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Host response to human breast Invasive Ductal Carcinoma (IDC) as observed by changes in the stromal proteome. | Following initial transformation, tumorigenesis, growth, invasion, and metastasis involves a complex interaction between the transformed tissue and the host, particularly in the microenvironment adjacent to the developing tumor. The tumor microenvironment itself is a unique outcome of the host reacting to the tumor and... | 25,244,421 | [
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Free H₂ rotation vs Jahn-Teller constraints in the nonclassical trigonal (TPB)Co-H₂ complex. | Proton exchange within the M-H2 moiety of (TPB)Co(H2) (Co-H2; TPB = B(o-C6H4P(i)Pr2)3) by 2-fold rotation about the M-H2 axis is probed through EPR/ENDOR studies and a neutron diffraction crystal structure. This complex is compared with previously studied (SiP(iPr)3)Fe(H2) (Fe-H2) (SiP(iPr)3 = [Si(o-C6H4P(i)Pr2)3]). Th... | 25,244,422 | [
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Ecological and evolutionary drivers of range size in Coenagrion damselflies. | Geographic range size is a key ecological and evolutionary characteristic of a species, yet the causal basis of variation in range size among species remains largely unresolved. One major reason for this is that several ecological and evolutionary traits may jointly shape species' differences in range size. We here pre... | 25,244,423 | [
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Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia. | Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia stem cells and their discrimination from normal hematopoietic stem cells would great... | 25,244,440 | [
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Committee opinion no 609: colorectal cancer screening strategies. | Each year, more than 24,000 women die from colorectal cancer, which makes it the third leading cause of cancer death in women after lung cancer and breast cancer. However, screening tests are underused for many segments of the population and are ordered in a manner inconsistent with guidelines. The primary goal of colo... | 25,244,458 | [
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Older and younger adults' accuracy in discerning health and competence in older and younger faces. | We examined older and younger adults' accuracy judging the health and competence of faces. Accuracy differed significantly from chance and varied with face age but not rater age. Health ratings were more accurate for older than younger faces, with the reverse for competence ratings. Accuracy was greater for low attract... | 25,244,467 | [
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Sclera color changes with age and is a cue for perceiving age, health, and beauty. | Redness or yellowness of the sclera (the light part of the eye) are known signs of illness, as is looking older than one's actual age. Here we report that the color of the sclera is related to age in a large sample of adult Caucasian females. Specifically, older faces have sclera that are more dark, red, and yellow tha... | 25,244,481 | [
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Vascular oxidative stress, nitric oxide and atherosclerosis. | In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide synthase (eNOS) and the mitochondrial electron transport chain. On the other hand, the vasculature is protected by antioxidant enzyme systems, includin... | 25,244,505 | [
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Comparison in efficacy between pure NOTES peritoneoscopy with small or large endoscope and laparoscopy. | To evaluate the efficacy and systematic impact of different sized endoscopes for pure transgastric natural orifice transluminal endoscopic surgery (NOTES) peritoneoscopy relative to laparoscopy. A total of 15 dogs were randomly assigned to the small-sized endoscope (SS), large-sized endoscope (LS) and standard laparosc... | 25,244,524 | [
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Dogs Entering the United States from Rabies-Endemic Countries, 2011-2012. | International dog imports pose a risk because of the potential movement of disease agents, including the canine rabies virus variant which has been eliminated from the United States since 2007. US regulations require a rabies vaccination certificate for dogs arriving from rabies-endemic countries, but permit the import... | 25,244,531 | [
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... |
Sex- and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese. | Sex- and age-related differences in mid-thigh composition and muscle quality remain unclear. The present study aimed to clarify these differences using computed tomography in middle-aged and elderly Japanese. A total of 2310 participants (age 40-89 years), who were randomly selected from the local residents, underwent ... | 25,244,543 | [
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Structural characterization and optical properties of Ca2MgSi2O7:Eu(2+),Dy(3+) phosphor by solid-state reaction method. | Ca2MgSi2O7:Eu(2+),Dy(3+) phosphor was prepared by the solid-state reaction method under a weak reducing atmosphere. The obtained phosphor was characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (ED... | 25,244,544 | [
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Aerobic oxidative Mannich reaction promoted by catalytic amounts of stable radical cation salt. | A catalytic amount of triarylaminium salt is demonstrated to be an efficient initiator for oxidative Mannich reaction of tertiary amines and nonactivated ketones under mild neutral conditions. Air is essential for this reaction and acts as a terminal oxidant. Metal catalysts, acid or base additives, and stoichiometric ... | 25,244,546 | [
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Correlates of implicit cognitive line length representation in two-dimensional space. | Twenty-eight sex- and age-matched participants, half dextrals and half sinstrals, were instructed to move a pen-sized planometer three inches (7.6 cm) while blindfolded. Under separate trials, movements were made at four angles, towards and away from the body, and at two distances from the body (30 cm, 53 cm). Half wer... | 25,244,556 | [
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Leukocyte telomere length and hemostatic factors in a South African cohort: the SABPA Study. | Incident atherothrombotic disease is predicted by leukocyte telomere length, a marker of biological age, and hemostatic factor levels, indicating a hypercoagulable state. We hypothesized that shorter telomeres are associated with elevated circulating levels of hemostatic factors. We examined 171 South African (black) a... | 25,244,563 | [
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Factors associated with persistence of red blood cell antibodies in woman after pregnancies complicated by fetal alloimmune haemolytic disease treated with intrauterine transfusions. | Red blood cell (RBC) antibodies can persist for decades or decrease quickly to undetectable levels. Antibody persistence has not been systematically studied. Women whose children are treated with intrauterine transfusions (IUT) for haemolytic disease of the fetus (HDFN) often produce additional antibodies, which can be... | 25,244,566 | [
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Association of overall survival in patients with newly diagnosed glioblastoma with contrast-enhanced perfusion MRI: Comparison of intraindividually matched T1 - and T2 (*) -based bolus techniques. | To compare intraindividual dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) MR perfusion parameters and determine the association of DCE parameters with overall survival (OS) with the established predictive DSC parameter cerebral blood volume (CBV) in patients with newly diagnosed glioblastoma.... | 25,244,574 | [
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Placental weight and placental weight to birthweight ratio in relation to Apgar score at birth: a population study of 522 360 singleton pregnancies. | To study whether placental weight or placental weight to birthweight ratio are associated with Apgar score in the newborn 5 min after birth. Population-based registry study. The Medical Birth Registry of Norway. All singleton live births during the period 1999-2008, a total of 522 360 births. The placental weight to bi... | 25,244,579 | [
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Characterization of miR-126-3p and its target talin2 in the bovine corpus luteum during the oestrus cycle. | Although clear advances have been made in understanding of gene transcriptional regulation in the corpous luteum (CL) during the oestrous cycle, little is known about the involvement of microRNAs (miRNAs) in this physiological process. In the present study, expression of miR-126-3p was preliminarily detected in bovine ... | 25,244,588 | [
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Rifaximin, gut microbes and mucosal inflammation: unraveling a complex relationship. | Rifaximin is a non-systemic, broad-spectrum antibiotic that acts against gram-positive, gram-negative, and anaerobic bacteria. Clinical studies indicate that rifaximin is beneficial in treating irritable bowel syndrome (IBS). The mechanism responsible for the beneficial effects of rifaximin is not clear. In a recent st... | 25,244,596 | [
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Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense? | The promise of off-the-shelf cellular therapeutics (CTPs) based on allogeneic induced pluripotent stem cells (iPSCs) may be hindered by alloimmunity, leading many to suggest that such products could be based on a series of human leukocyte antigen (HLA)-typed iPSC lines allowing at least some degree of tissue matching. ... | 25,244,598 | [
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Regulation of innate immunity by the molecular machinery of macroautophagy. | Innate immune responses are the first line of defence for an organism to restrict invading pathogens. They fulfil two main functions, namely detection of the pathogen to successively alarm the appropriate components of the immune system and early inhibition of the infection to prevent demise of the infected organism be... | 25,244,600 | [
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Oligonucleotide flexibility dictates crystal quality in DNA-programmable nanoparticle superlattices. | The evolution of crystallite size and microstrain in DNA-mediated nanoparticle superlattices is dictated by annealing temperature and the flexibility of the interparticle bonds. This work addresses a major challenge in synthesizing optical metamaterials based upon noble metal nanoparticles by enabling the crystallizati... | 25,244,608 | [
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Factors associated with self-rated oral health among community-dwelling older Japanese: A cross-sectional study. | A cross-sectional study was carried out to investigate the determinants of self-rated oral health among community-dwelling older people in Japan. The participants were 897 (357 men and 540 women) aged 65 years and over who participated in a comprehensive geriatric health examination, which included an oral examination,... | 25,244,626 | [
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Termite (order Blattodea, infraorder Isoptera) baiting 20 years after commercial release. | Termite baiting is now one of the two main management tools in developed countries after 20 years of commercial release. It has two main goals: to use small amounts of active ingredient and 'colony elimination', i.e. death of all individuals in the colony. We consider how well baiting has been evaluated from 100 studie... | 25,244,627 | [
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Desired alteration of protein affinities: competitive selection of protein variants using yeast signal transduction machinery. | Molecules that can control protein-protein interactions (PPIs) have recently drawn attention as new drug pipeline compounds. Here, we report a technique to screen desirable affinity-altered (affinity-enhanced and affinity-attenuated) protein variants. We previously constructed a screening system based on a target prote... | 25,244,640 | [
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The Norway Couple Project: Lessons Learned. | Couple therapists in routine practice may find it difficult to apply findings from an increasingly expanding and complex body of couple therapy research. Meanwhile, concerns have been raised that competency in evidence-based treatments is insufficient to inform many practice decisions or ensure positive treatment outco... | 25,244,649 | [
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International confederation for cleft lip and palate and related craniofacial anomalies task force report: beyond eurocleft. | The assigned objective for the Task Force Beyond Eurocleft was "to make recommendations for initiations of local and/or participation in multi-national cleft outcome studies and consist of individuals from the European experience with cleft outcome studies (Scandcleft, Eurocleft) and those who have initiated, or intend... | 25,244,656 | [
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Conserved microsatellites in ants enable population genetic and colony pedigree studies across a wide range of species. | Broadly applicable polymorphic genetic markers are essential tools for population genetics, and different types of markers have been developed for this purpose. Microsatellites have been employed as particularly polymorphic markers for over 20 years. However, PCR primers for microsatellite loci are often not useful out... | 25,244,681 | [
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Burden of arthritis in Delaware: implications for public health. | Delaware's older population is increasing at a faster rate than in most other states. The number of adults with arthritis is expected to increase sharply in the coming years, thus making it important to explore the burden of this leading cause of disability at the state and local level. This study explored the burden o... | 25,244,724 | [
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[Clinical examination of 3 patients with delayed neuropsychiatric encephalopathy induced by carbon monoxide poisoning, who recovered from severe neurocognitive impairment by repetitive hyperbaric oxygen therapy]. | We performed hyperbaric oxygen (HBO) therapy for 3 patients with delayed neuropsychiatric encephalopathy induced by carbon monoxide (CO) poisoning. All patients were male and around 50 years old, and they had not received HBO therapy within 24 h after CO poisoning, even though they showed severe consciousness disturban... | 25,244,729 | [
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[Identification of cattail pollen (puhuang), pine pollen (songhuafen) and its adulterants by ITS2 sequence]. | DNA barcoding method was conducted for the authentication of pollen materials due to difficulty of discriminating pollen materials bearing morphological similarity. In this study, a specific focus was to identify cattail pollen (Puhuang) and pine pollen (Songhuafen) samples from their adulterants which are frequently m... | 25,244,742 | [
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[Effects of amino acid on growth and secondary metabolites contents of adventitious roots of Tripterygium wilfordii]. | The adventitious root of Tripterygium wilfordii was used as experiment material to study effects of various concentration of aspartic acid, isoleucine, cysteine and arginine in MS medium on the growth and triptolide, wilforgine, wilforine contents of the adventitious roots. The results showed that compared with the con... | 25,244,757 | [
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[HPLC determination of two phenylpropanoid amides in solani melongenae radix from different cultivation regions]. | A quantitative HPLC-DAD method was developed for simultaneous determination of N-trans-p-coumaroyloctopamine and N-trans-p-coumaroyltyramine in Solani Melongenae Radix from different cultivation regions in China The separation was performed on an Agilent Eclipse XDB C18 column (4.6 mm x 250 mm, 5 microm) at 30 degrees ... | 25,244,763 | [
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[Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. | The changes of pain threshold and expression of 5-hydroxytryptamine(5-HT) and c-Fos in spinal dorsal horn of rats were observed after targetedly damaged the cerebraspinal fluid-contacting nucleus (CSF-contacting nucleus) to provide experimental evidence for the mechanism of regulating pain CSF-contacting nucleus involv... | 25,244,785 | [
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[Analysis of the phase of left ventricular isovolumic relaxation time in healthy people using dual-channel echocardiography]. | To exacted analysis each time interval in isovolumic relaxation time (IVRT) of normal subjects through observin the changes of cardiac structure and hemodynamics during the IVRT. Then to provide the evidence of cardiac resynchronization therapy. Quantitative analysis was performed for 60 subjects. The dual-channel echo... | 25,244,797 | [
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[A randomized controlled trial: acclimatization training on the prevention of motion sickness in hot-humid environment]. | Incidence and severity of motion sickness (MS) in hot-humid environment are extremely high. We tried to know the effect of two-stage training for reducing incidence and severity of ms. Sixty male subjects were divided into experimental group and control group randomly. Subjects in experimental group received: (2) adapt... | 25,244,801 | [
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-0.00615478,
-0.2910777,
0.4193743,
-0.3682... |
[Anthropogenic VOC emission inventory and contribution from industrial sources in Ningbo]. | Ningbo is an important industrial city in eastern China and is also the economic center in the south wing of the Yangtze River Delta (YRD). Recently, the VOC emissions from the local industrial activities and its effects on both the regional air quality and people's health were getting more and more attention. The anth... | 25,244,829 | [
-0.2200048,
0.1297385,
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0.3034607,
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-0.3901894,
0.2397454,
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0.02030627,
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0.02619607,
0.08719037,
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-0.3107333,
0.3265282,
0.2850615,
0.2872507,
-0.06930797,
0.6251513,
-0.2326977,... |
[Investigation of enhanced low carbon wastewater denitrification by catalytic iron]. | The nitrogen removal efficiency and N2O production during the process of coupling catalytic iron and biological denitrification for low C/N ratio wastewater were studied. The results showed that biological denitrification coupled with catalytic iron could significantly improve nitrate transforming efficiency, but led t... | 25,244,848 | [
-0.2967296,
0.4305595,
0.08999218,
0.3025307,
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0.09028863,
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0.1183957,
0.3022996,
0.2334,
-0.1867382,
0.3959221,
-0.2006822,
0.0007... |
[Distribution and ecological risk assessment of polycyclic aromatic hydrocarbons in surface sediments and soils from Ddishui Lake and its water exchange areas]. | Twenty-three surface sediment samples were collected from Dishui Lake and its surroundings, and 16 polycyclic aromatic hydrocarbons (PAHs) were analyzed using GC-MS. The distribution characteristics, possible sources and ecological risk were investigated. The results show that the concentrations of total PAHs range bet... | 25,244,853 | [
-0.06435641,
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0.4646547,
0.00587423,
0.01635114,
0.1141535,
-0.1494651,... |
[Steam and air co-injection in removing TCE in 2D-sand box]. | Steam and air co-injection is a newly developed and promising soil remediation technique for non-aqueous phase liquids (NAPLs) in vadose zone. In this study, in order to investigate the mechanism of the remediation process, trichloroethylene (TCE) removal using steam and air co-injection was carried out in a 2-dimensio... | 25,244,869 | [
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0.2782604,
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0.1962183,
0.3804514,
0.2184675,
0.4211423,
-0.070036... |
Urgent-start peritoneal dialysis: nursing aspects. | Urgent-start peritoneal dialysis (PD) refers to the initiation of dialysis soon after a PD catheter placement and is a treatment option available to the late-referred patient with advanced kidney disease. This article reviews nursing aspects of urgent-start PD and can serve as a guide for this evolving clinical pathway... | 25,244,889 | [
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... |
Altruism, efficiency, and health in the family. | The chapter investigates: (1) Do married parents efficiently allocate time to children's health care? (2) Are parents willing to sacrifice consumption for health improvements at an equal rate for all family members? (3) How does family structure affect health trade-offs parents make? (4) Are parental choices consistent... | 25,244,905 | [
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0.2050927,
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0.1995644,
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0.2560396,
-0.3450888,
0.02836017,
0.1542842,
0.0195032,
0.03492612,
0.19... |
Mutual altruism: evidence from Alzheimer patients and their spouse caregivers. | Preferences of both Alzheimer patients and their spouse caregivers are related to a willingness-to-pay (WTP) measure which is used to test for the presence of mutual (rather than conventional unilateral) altruism. Contingent valuation experiments were conducted in 2000-2002, involving 126 Alzheimer patients and their c... | 25,244,908 | [
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0.04735764,
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0.1020294,
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0.03461505,
0.2628335,
0.... |
On edge chipping testing and some personal perspectives on the state of the art of mechanical testing. | The edge chipping test is used to measure the fracture resistance of dental restoration ceramics and resin composites. This paper focuses on the progress of evaluating chipping resistance of these materials and also on the progress of standardization of this test method. This paper also makes observations about the sta... | 25,244,927 | [
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0.04816455,
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0.09251774,
0.09589677,
0.12528... |
Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis. | Genomic instability promotes colon carcinogenesis by inducing genetic mutations, but not all genes affected by this process have been identified. We investigated whether genomic instability in human colorectal cancer (CRC) cells produces mutations in the hepatocyte growth factor (HGF) gene. We genotyped human colon tum... | 25,244,939 | [
-0.0227584,
-0.2579835,
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0.1273667,
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0.2701332,
0.1244516,
0.3609705,
0.3156009,
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Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. | Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an intracellular signaling species. The phospholipase D superfamily plays a central role in a variety of functions in prokaryotes, viruses, yeast, fungi, plants, and eukaryotic species. In mammalian cells, the pathways modulating catal... | 25,244,928 | [
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0.2296552,
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0.2180011,
0.2126185,
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0.05015317,
0.4042923,
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0.260807,
0.3356878,
-0.3756957,
0... |
Effect of sequential induction by Mamestra brassicae L. and Tetranychus urticae Koch on lima bean plant indirect defense. | Attack by multiple herbivores often leads to modification of induced plant defenses compared to single herbivory, yet little is known about the effects on induced indirect plant defense. Here, we investigated the effect of sequential induction of plant defense by Mamestra brassicae caterpillar oral secretion and an inf... | 25,244,951 | [
0.2625244,
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0.1648429,
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0.234632,
0.4741057,
0.1945336,
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0.2... |
Complete genome sequence of a divergent strain of Japanese yam mosaic virus from China. | A novel strain of Japanese yam mosaic virus (JYMV-CN) was identified in a yam plant with foliar mottle symptoms in China. The complete genomic sequence of JYMV-CN was determined. Its genomic sequence of 9701 nucleotides encodes a polyprotein of 3247 amino acids. Its organization is virtually identical to that of two JY... | 25,244,960 | [
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0.04999311,
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0.2236696,
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0.028234,
0.4925953,
0.2186283,
-0.2709078,
0.1259985,
0.03798641,
-0.2900383,
0.030... |
Risk of melanoma and non-melanoma skin cancer in ulcerative colitis patients treated with thiopurines: a nationwide retrospective cohort. | There are limited data on the risk of non-melanoma skin cancer (NMSC) and melanoma skin cancer (MSC) among thiopurine-treated patients with ulcerative colitis (UC). Our aim was to investigate the risk while on, by cumulative years, and after stopping thiopurine therapy. Nationwide data were obtained from the Veterans A... | 25,244,964 | [
0.1473916,
-0.4856862,
-0.6058024,
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0.2157954,
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0.02304534,
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0.2146758,
0.01528846,
0.07552517,
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0.2411189,
0.1329691,
-0.07737826,
... |
Causes and features of erythroderma. | Erythroderma is a generalised inflammatory reaction of the skin secondary to a variety of causes. This retrospective study aims to characterise the features of erythroderma and identify the associated causes of this condition in our population. We reviewed the clinical, laboratory, histological and other disease-specif... | 25,244,987 | [
0.06820121,
-0.169577,
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0.1245564,
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0.1433837,
0.1820064,
0.1523424,
0.09636367,
0.1566089,
-0.237542,
-0... |
Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi. | Anopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of mosquito-parasite interactions. The type form of the species is responsible for the majority of urban malaria transmission across its range. Here, we report the ... | 25,244,985 | [
0.3012529,
0.1683539,
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0.2082519,
0.189859,
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0.06575171,
0.05127598,
-0.106337... |
Pertactin-negative Bordetella pertussis strains in Canada: characterization of a dozen isolates based on a survey of 224 samples collected in different parts of the country over the last 20 years. | To detect and characterize pertactin-negative Bordetella pertussis in Canada, especially for isolates collected in recent years. A total of 224 isolates from the years 1994-2013 were screened by Western immuno-blot for expression of pertactin. Pertactin-negative isolates were characterized by serotyping, pulsed-field g... | 25,244,999 | [
0.004454661,
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0.01976206,
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0.09602553,
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0.01040539,
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0.3365996,
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0.2716017,
0.6184072,
-0.12309... |
Co nanoparticles induced resistive switching and magnetism for the electrochemically deposited polypyrrole composite films. | The resistive switching behavior of Co-nanoparticle-dispersed polypyrrole (PPy) composite films is studied. A novel design method for resistive random access memory (ReRAM) is proposed. The conducting polymer films with metal nanocrystal (NC)-dispersed carbon chains induce the spontaneous oxidization of the conducting ... | 25,245,009 | [
-0.336429,
0.2345657,
0.02261872,
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0.1307819,
0.09299295,
-0.1803458,
-0.04... |
Association between XRCC1 polymorphisms and glioma risk among Chinese population. | The pathogenesis of glioma remains largely unknown now. It has been suggested that the X-ray cross-complementing group 1 (XRCC1) gene may influence the capacity to repair DNA damage leading to an increased gliomas susceptibility. This study aimed to evaluate the relationship between XRCC1 polymorphisms and glioma risk.... | 25,245,010 | [
-0.001044006,
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0.02534705,
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0.0340048,
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0.0389102,
0.3714116,
0.09936683,
0.08274681,
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-0.2420023,
0.1588345,
-0.03902219,
0.04007255,
-0.1561953,
0.242716,
-0.021488... |
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