title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Inhibition of transforming growth factor β signaling promotes epiblast formation in mouse embryos. | Early lineage segregation in preimplantation embryos and maintenance of pluripotency in embryonic stem cells (ESCs) are both regulated by specific signaling pathways. Small molecules have been shown to modulate these signaling pathways. We examined the influence of several small molecules and growth factors on second-l... | 25,245,024 | [
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Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair. | Nasopharyngeal carcinoma (NPC), while uncommon worldwide, is a major health problem in China. Although local radiation and surgery provide good control of NPC, better treatments that permit reductions in radiation dosing are needed. Inhibition of protein phosphatase 2A (PP2A), a ubiquitous multifunctional enzyme with c... | 25,245,035 | [
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Effectiveness and toxicity of high-dose cyclophosphamide in obese versus non-obese patients receiving allogeneic hematopoietic stem cell transplant. | To determine if there is a difference in toxicity and effectiveness between obese and non-obese patients who receive high-dose cyclophosphamide (Cy) prior to allogeneic hematopoietic stem cell transplant (allo-HCT). Patients were included in this study if they were at least 18 years of age and received high-dose Cy in ... | 25,245,037 | [
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Heterogeneity in venous disease practice patterns amongst primary healthcare practitioners. | This study aimed to describe the practice patterns of primary healthcare practitioners who diagnose and manage venous disease to determine differences in clinical evaluation of disease, recognition of venous ulcers, and referral patterns. A survey was distributed at the August 2011 Primary Care Medical Conference (Pri-... | 25,245,047 | [
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A moving overlay shrinks the attentional blink. | This report describes a study examining the effects of overlaying a veil of spots on the letters in a central rapid serial visual presentation stream. Observers identified two target letters (T1 and T2, respectively) embedded in a stream of distractor letters printed in a different color. In Experiment 1, the attention... | 25,245,077 | [
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Gene therapy for chronic granulomatous disease: current status and future perspectives. | Several Phase I/II clinical trials aiming at the correction of X-linked CGD by gene transfer into hematopoietic stem cells (HSCs) have demonstrated the therapeutic potential of gene modified autologous HSCs for the treatment of CGD. Resolution of therapy-resistant bacterial and fungal infections in liver, lung and spin... | 25,245,086 | [
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Layered double hydroxides as an effective additive in polymer gelled electrolyte based dye-sensitized solar cells. | Layered double hydroxides (LDH), a class of anionic clay materials, were developed as an effective additive for polymer gelled electrolytes for use in dye-sensitized solar cells (DSSC). Carbonate and chloride intercalated Zn-Al LDHs, ZnAl-CO3 LDH, and ZnAl-Cl LDH were prepared with coprecipitation methods. The addition... | 25,245,099 | [
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Risk of leukaemia and residential exposure to air pollution in an industrial area in Northern Italy: a case-control study. | Leukaemia risk in adult populations exposed to environmental air pollution is poorly investigated. We have carried out a population-based case-control study in an area that included a fossil fuel power plant, a coke oven and two big chemical industries. Information on residential history and several risk factors for le... | 25,245,102 | [
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FoxO3 is a negative regulator of primary CD8+ T-cell expansion but not of memory formation. | The generation of CD8(+) T cells by vaccination represents an important goal for protective immunity to infectious pathogens. It is thus of utmost importance to understand the mechanisms involved in the generation of optimal CD8(+) T-cell responses. The forkhead box O (FoxO) family of transcription factors has a crucia... | 25,245,112 | [
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Outcomes after subtotal parathyroidectomy for primary hyperparathyroidism due to hyperplasia: significance of whole vs. partial gland remnant. | Primary hyperparathyroidism (PHPT) due to multigland hyperplasia is managed by subtotal parathyroidectomy (sPTX), with a partial gland left in situ. However, smaller, hyperplastic glands may be encountered intraoperatively, and it is unclear if leaving an intact gland is an equivalent alternative. This study evaluates ... | 25,245,126 | [
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Perceived control and intrinsic vs. extrinsic motivation for oral self-care: a full factorial experimental test of theory-based persuasive messages. | Correlational evidence suggests that perceived control (PC) and intrinsic motivation (IM), key constructs in social cognitive and self-determination theories, may interact to reinforce behavior change. This proof-of-principle study examines the independent and synergistic effects of interventions to increase PC and IM ... | 25,245,138 | [
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FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. | The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. Systemic and central (i.c.v.) administration of the FAAH inhibitor URB597 increased hippocampal levels of the N-acylethanolamines palmitoylethanolamide an... | 25,245,162 | [
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Qualitative evaluation of the relevance and acceptability of a web-based HIV prevention game for rural adolescents. | African Americans in the rural Southern United States continue to experience disproportionate increases in new HIV/AIDS infections. Electronic gaming interventions hold promise but the use of HIV prevention games is limited. The purpose of this study was to assess the acceptability and relevance of a web-based HIV prev... | 25,245,160 | [
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Migraine is associated with altered processing of sensory stimuli. | Migraine is associated with derangements in perception of multiple sensory modalities including vision, hearing, smell, and somatosensation. Compared to people without migraine, migraineurs have lower discomfort thresholds in response to special sensory stimuli as well as to mechanical and thermal noxious stimuli. Like... | 25,245,197 | [
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Carbapenem resistance in a human clinical isolate identified to be closely related to Acinetobacter indicus. | Here we report a case of carbapenem resistance in a human clinical isolate that was found to be closely related to the newly described environmental species Acinetobacter indicus. This strain harboured the blaOXA-23 carbapenemase gene located on a conjugative plasmid. Partial sequencing of 16S rDNA and rpoB genes, toge... | 25,245,212 | [
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IVUS-based FSI models for human coronary plaque progression study: components, correlation and predictive analysis. | Atherosclerotic plaque progression is believed to be associated with mechanical stress conditions. Patient follow-up in vivo intravascular ultrasound coronary plaque data were acquired to construct fluid-structure interaction (FSI) models with cyclic bending to obtain flow wall shear stress (WSS), plaque wall stress (P... | 25,245,219 | [
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HPLC-DAD analysis, antioxidant potential and anti-urease activity of Asparagus gracilis collected from District Islamabad. | Asparagus gracilis subspecie of Asparagus capitatus Baker, is described as food and medicine for various ailments. In this study we investigated, its phenolic constituents, in vitro antioxidant potential against various free radicals and anti-urease potential. Asparagus gracilis aerial parts collected from District Isl... | 25,245,231 | [
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Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. | The follicle destiny towards ovulation or atresia is multi-factorial in nature and involves outcries, paracrine and endocrine factors that promote cell proliferation and survival (development) or unchain apoptosis as part of the atresia process. In several types of cells, sphingosine-1-phospate (S1P) promotes cellular ... | 25,245,232 | [
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Elastin-derived peptides stimulate trophoblast migration and invasion: a positive feedback loop to enhance spiral artery remodelling. | Elastin breakdown in the walls of uterine spiral arteries during early pregnancy facilitates their transformation into dilated, high-flow, low-resistance channels. Elastin-derived peptides (EDP) can influence cell migration, invasion and protease activity, and so we hypothesized that EDP released during elastolysis pro... | 25,245,255 | [
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The noisy encoding of disparity model of the McGurk effect. | In the McGurk effect, incongruent auditory and visual syllables are perceived as a third, completely different syllable. This striking illusion has become a popular assay of multisensory integration for individuals and clinical populations. However, there is enormous variability in how often the illusion is evoked by d... | 25,245,268 | [
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Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment. | Amphipathic tail-anchoring peptide (ATAP) derived from the human anti-apoptotic protein Bfl-1 is a potent inducer of apoptosis by targeting mitochondria permeability transition. By linking ATAP to an internalizing RGD peptide (iRGD), selective targeting for ATAP to tumor cell was achieved. Confocal fluorescence microsc... | 25,245,280 | [
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Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme. | Epithin/PRSS14, a type II transmembrane serine protease, plays critical roles in cancer metastasis. Previously, we have reported that epithin/PRSS14 undergoes ectodomain shedding in response to phorbol myristate acetate (PMA) stimulation. In this study, we show that transforming growth factor-β (TGF-β) induces rapid ep... | 25,245,289 | [
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Understanding and controlling type I collagen adsorption and assembly at interfaces, and application to cell engineering. | Collagen is a large anisotropic and self-assembling extracellular matrix protein. Understanding and controlling its adsorption and assembly at interfaces is expected to increase our general knowledge of protein adsorption as well as to open the way to the development of biointerfaces of interest for biomaterials scienc... | 25,245,299 | [
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Effects of weight loss on foot structure and function in obese adults: a pilot randomized controlled trial. | To investigate the effects of weight reduction on foot structure, gait, and dynamic plantar loading in obese adults. In a 3-month randomized-controlled trial, participants were randomized to receive either a weight loss intervention based on portion-controlled meals or a delayed-treatment control. 41 adults (32 F, 9 M)... | 25,245,307 | [
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[The elderly in radiotherapy: myths and prospects]. | In this single-center retrospective case-control study, 62 patients were divided into two age groups (80 years and older versus less than 65 years) treated with external beam radiation during the same period. The main objective was to investigate differences in care between these two populations. Two parameters appear ... | 25,245,312 | [
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Bone mineral density in women with polycystic ovary syndrome. | PCOS is a complex disorder and various features of this disorder may have great importance for bone metabolism. The aim of the study was to determine the relationship between existing hormonal disorders, and bone mineral density (BMD) in young women with PCOS. 69 reproductive-aged PCOS women and 30 age-matched healthy ... | 25,245,338 | [
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Early generalized overgrowth in autism spectrum disorder: prevalence rates, gender effects, and clinical outcomes. | Although early head and body overgrowth have been well documented in autism spectrum disorder (ASD), their prevalence and significance remain unclear. It is also unclear whether overgrowth affects males and females differentially, and whether it is associated with clinical outcomes later in life. To evaluate prevalence... | 25,245,350 | [
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Increased risk of autism spectrum disorders at short and long interpregnancy intervals in Finland. | Both short and long interpregnancy intervals (IPI) are believed to present possible adverse conditions for fetal development. Short IPI has recently been associated with increased risk of autism, but whether long IPI increases risk for autism spectrum disorders (ASD) has not been thoroughly investigated. We investigate... | 25,245,351 | [
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Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. | Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuou... | 25,245,356 | [
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Condrosulf®: structural characterization, pharmacological activities and mechanism of action. | Condrosulf(®) is a pharmaceutical formulation containing chondroitin sulfate (CS) as an active component possessing high quality and purity and standardized properties. CS is currently applied as a SYSADOA (Symptomatic Slow Acting Drug for Osteoarthritis) agent in Europe in the treatment of osteoarthritis (OA). Further... | 25,245,376 | [
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Effect of long-term antihypertensive treatment on white-coat hypertension. | Limited evidence is available on the extent and frequency by which antihypertensive treatment lowers office blood pressure (BP) in white-coat hypertension (WCH). Data are even more scanty and discrepant on the corresponding effect on ambulatory BP (ABP). In the hypertensive patients of the European Lacidipine Study on ... | 25,245,386 | [
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CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype. | Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by s... | 25,245,389 | [
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Pharyngocutaneous fistula after total laryngectomy: a single-institution experience, 2001-2012. | The purpose of this study was to determine the incidence of and risk factors for pharyngocutaneous fistula in patients undergoing total laryngectomy at a single institution. The records of 59 patients undergoing primary or salvage total laryngectomy at our institution from 2001 to 2012 were retrospectively reviewed. Da... | 25,245,411 | [
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Soft tissue airway dimensions and craniocervical posture in subjects with different growth patterns. | To compare the dimensions of the nasopharynx and oropharynx of subjects with different growth patterns and to determine whether any correlation exists with their craniocervical posture. Cephalometric radiograph of 60 subjects (16-25 years old), taken in natural head position, were divided into three groups according to... | 25,245,417 | [
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Tamibarotene as maintenance therapy for acute promyelocytic leukemia: results from a randomized controlled trial. | The introduction of all-trans-retinoic acid (ATRA) has significantly improved outcomes for acute promyelocytic leukemia (APL), although a subset of patients still suffer relapse. The purpose of this study was to evaluate the role of maintenance therapy with the synthetic retinoid tamibarotene in APL. Patients with newl... | 25,245,439 | [
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Randomized phase III trial of retinoic acid and arsenic trioxide versus retinoic acid and chemotherapy in patients with acute promyelocytic leukemia: health-related quality-of-life outcomes. | A randomized clinical trial compared efficacy and toxicity of standard all-trans-retinoic acid (ATRA) plus chemotherapy versus ATRA plus arsenic trioxide in patients with newly diagnosed, low- or intermediate-risk acute promyelocytic leukemia (APL). Here, we report health-related quality-of-life (HRQOL) results. HRQOL ... | 25,245,446 | [
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Expression of leptin and its long form receptor at the porcine maternal-fetal interface: contrasting healthy and arresting conceptus attachment sites during early and mid-pregnancy. | It is well established that spontaneous conceptus loss in swine is associated with an imbalance of both angiogenic and immunological factors. Leptin (LEP), a metabolic hormone, has also been implicated in the promotion of angiogenesis. In this study, LEP and its long form receptor (OB-Rb) were evaluated during porcine ... | 25,245,493 | [
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Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. | Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellular... | 25,245,500 | [
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[RALP: comparison of the oncological and functional outcomes of the intrafascial and the interfascial approaches]. | Due to its technical ease and greater precision Robotic Assisted Laparoscopic radical Prostatectomy (RALP) allows a better preservation of the neurovascular bundles, thereby improving functional outcomes. The intrafascial dissection has been proposed to allow a more complete preservation of these bundles. However, this... | 25,245,504 | [
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Effects of using Nintendo Wii™ exergames in older adults: a review of the literature. | The purpose of this review is to summarize and synthesize the impact of using the Nintendo Wii™ exergames in older adults. A database search was conducted to identify relevant studies. The search was limited to empirical studies, with particular attention paid to the effects of Wii exergames intervention on cognition, ... | 25,245,519 | [
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State of Fukushima nuclear fuel debris tracked by Cs137 in cooling water. | It is still difficult to assess the risk originating from the radioactivity inventory remaining in the damaged Fukushima nuclear reactors. Here we show that cooling water analyses provide a means to assess source terms for potential future releases. Until now already about 34% of the inventories of (137)Cs of three rea... | 25,245,528 | [
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Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. | The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N(2)-deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA expression data, to ... | 25,245,543 | [
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Job insecurity is associated with adult asthma in Germany during Europe's recent economic crisis: a prospective cohort study. | Job insecurity has been identified as a risk factor for adverse health outcomes. Perceptions of job insecurity steeply increased during Europe's recent economic downturn, which commenced in 2008. The current study assessed whether job insecurity was associated with incident asthma in Germany during this period. We used... | 25,245,545 | [
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Biochemical measurements of beef are a good predictor of untrained consumer sensory scores across muscles. | The ability of the biochemical measurements, haem iron, intramuscular fat (IMF%), moisture content, and total, soluble and insoluble collagen contents, to predict untrained consumer sensory scores both across different muscles and within the same muscle from different carcasses were investigated. Sensory scores from 54... | 25,245,561 | [
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Longitudinal performance of an implantable vestibular prosthesis. | Loss of vestibular function may be treatable with an implantable vestibular prosthesis that stimulates semicircular canal afferents with biphasic pulse trains. Several studies have demonstrated short-term activation of the vestibulo-ocular reflex (VOR) with electrical stimulation. Fewer long-term studies have been rest... | 25,245,586 | [
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Mental health state and quality of life questionnaire in low vision assessment: a case report. | Vision impairment associated with diabetic retinopathy, is well known and low vision rehabilitation is always recommended. In this report, the importance of objective measure of mental health and quality of life screening in diabetic retinopathy low-vision assessment is discussed. We describe the case of a 43-year-old ... | 25,245,590 | [
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Emergence of rice yellow mottle virus in eastern Uganda: Recent and singular interplay between strains in East Africa and in Madagascar. | Epidemics of rice yellow mottle virus (RYMV) have developed recently in eastern Uganda, close to Lake Victoria in East Africa. Unexpectedly, all isolates from the affected area belonged to a single strain (named S4ug), a strain that is different from the S4lv strain that has been prevalent in the Lake Victoria basin fo... | 25,245,592 | [
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Efficacy of endoscopic ultrasound-guided hemostatic interventions for resistant nonvariceal bleeding. | A subset of patients with nonvariceal gastrointestinal bleeding fail, or are unsuitable candidates for, endoscopic, radiologic, and surgical interventions. Endoscopic ultrasound (EUS)-guided intervention might be effective in these patients. We performed EUS-guided hemostatic interventions for 17 patients with nonvaric... | 25,245,627 | [
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Structure-function analysis of hepatitis C virus envelope glycoproteins E1 and E2. | Hepatitis C virus (HCV) is the leading cause of chronic liver disease in humans. The envelope proteins of HCV are potential candidates for vaccine development. The absence of three-dimensional (3D) structures for the functional domain of HCV envelope proteins [E1.E2] monomer complex has hindered overall understanding o... | 25,245,635 | [
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A bizarre parosteal osteochondromatous proliferation (Nora's lesion) of metatarsus, a histopathological and etiological puzzlement. | Nora's lesion (bizarre parosteal osteochondromatous proliferation) is a rare, benign lesion that is composed of differing amounts of cartilage, bone, and spindle cells and an unusual form of calcified cartilage so-called "blue bone". Whether it represents a reactive proliferation or a neoplastic lesion still remains co... | 25,245,639 | [
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Causes and treatments of lag screw's cut out after intramedullary nailing osteosinthesis for trochanteric fractures. | Background. Superior cut-out of a lag screw remains a serious complication in the treatment of trochanteric or subtrochanteric fractures and it is related to many factors: the type of fracture, osteoporosis and the stability of fracture reduction. Little is known about the outcome after revision surgery for complicatio... | 25,245,649 | [
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Results after revision of the stem in periprosthetic fractures of the hip. | Periprosthetic femoral fractures following primary total hip arthroplasty (THA) represent an emerging challenge for the orthopaedic surgeon, because of their increasing incidence and negative impact on clinical and functional patient outcome. For these reasons, in the last decade, many efforts were made to prevent and ... | 25,245,651 | [
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Severe hypokalemia and hypophosphatemia presenting with carpopedal spasm associated with rhabdomyolysis. | Background Severe hypokalemia, defined as serum potassium < 2.5 mEq/L, may lead to neuromuscular, gastrointestinal, and ECG abnormalities. Neuromuscular consequences of hypokalemia include weakness, cramps, rarely paralysis, eventually progressing to rhabdomyolysis. Case presentation We report a case of a 4-year... | 25,245,653 | [
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Using correlative light and electron microscopy to study zebrafish vascular morphogenesis. | Live imaging is extremely useful to characterize the dynamics of cellular events in vivo, yet it is limited in terms of spatial resolution. Correlative light and electron microscopy (CLEM) allows combining live confocal microscopy with electron microscopy (EM) for the characterization of biological samples at high temp... | 25,245,685 | [
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Light sheet-based imaging and analysis of early embryogenesis in the fruit fly. | The fruit fly is an excellent model system for investigating the sequence of epithelial tissue invaginations constituting the process of gastrulation. By combining recent advancements in light sheet fluorescence microscopy (LSFM) and image processing, the three-dimensional fly embryo morphology and relevant gene expres... | 25,245,688 | [
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Simulating tissue morphogenesis and signaling. | During embryonic development tissue morphogenesis and signaling are tightly coupled. It is therefore important to simulate both tissue morphogenesis and signaling simultaneously in in silico models of developmental processes. The resolution of the processes depends on the questions of interest. As part of this chapter ... | 25,245,703 | [
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An apical left ventricular aneurysm rupture presenting as left breast mass 11 years after surgical repair. | Left ventricular (LV) pseudoaneurysm is a rare entity and, consequently, there is limited knowledge of the condition's natural history. The most frequent mode of presentation for LV pseudoaneurysm is heart failure with chest pain. However, the variable presentation of this condition requires a high index of suspicion f... | 25,245,713 | [
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Delayed diagnosis in metastatic lesions of the foot. | Pedal acrometastases are a rare complication of disseminated malignancy. To date, there is little in the literature documenting their clinical course. Our large orthopaedic oncology database was used to review the clinical course of symptomatic pedal acrometastases. A total of 15 cases of pedal acrometastases were iden... | 25,245,734 | [
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A retrospective case note review of laparoscopic versus open reversal of Hartmann's procedure. | First described in 1921, Hartmann's procedure is the gold standard treatment for complicated sigmoid diverticular disease. It is also used commonly for other causes of perforation of the large bowel. However, the reversal rate in the UK is much lower than in comparable countries, at only 18-22%. Furthermore, laparoscop... | 25,245,735 | [
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Cancer immunoprevention--the next frontier. | Cancer immunotherapy is a rapidly developing field, but limited in its success by a high tumor burden and immune tolerance. In contrast, immunoprevention has the potential to prevent cancer before the development of immune tolerance, and to prevent cancer recurrence in the setting of minimal residual disease. Although ... | 25,245,763 | [
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A nomogram to predict disease-free survival after surgical resection of GIST. | Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Adjuvant imatinib therapy has resulted in improved disease-free survival (DFS) following resection of primary GIST. The aim of our study was to create a nomogram to predict DFS following resection of GIST. Usin... | 25,245,766 | [
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The Reference Ability Neural Network Study: motivation, design, and initial feasibility analyses. | We introduce and describe the Reference Ability Neural Network Study and provide initial feasibility data. Based on analyses of large test batteries administered to individuals ranging from young to old, four latent variables, or reference abilities (RAs) that capture the majority of the variance in age-related cogniti... | 25,245,813 | [
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[Ovulation induction by pulsatile GnRH therapy in 2014: literature review and synthesis of current practice]. | The hypogonadotropic hypogonadism is an easily treatable form of female infertility. The most common cause of hypogonadotropic hypogonadism is functional hypothalamic amenorrhea. The GnRH pump is a simple and effective treatment to restore fertility of patients with hypothalamic amenorrhea: cumulative pregnancy rate is... | 25,245,838 | [
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Optical magnification devices in tonsillectomy: a prospective randomised clinical study. | Tonsillectomy is one of the most common surgical procedure in otorhinolaryngology. A plethora of approaches has been undertaken so far to limit postoperative pain, one of the major problems patients are concerned with. Thermal damages of the surrounding tissue caused by coagulation during surgery are discussed to corre... | 25,245,863 | [
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Medially placed vagus nerve in relation to common carotid artery: a pointer to a non-recurrent laryngeal nerve. | The aim of this study was to highlight a medialized vagus in relation to common carotid artery as an operative marker to a non-recurrent laryngeal nerve during thyroid surgeries. Three patients who underwent thyroidectomy, in who per operative diagnosis of right non-recurrent laryngeal nerve was made and the findings w... | 25,245,864 | [
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Long-term vascular contractility assay using genipin-modified muscular thin films. | Vascular disease is a leading cause of death globally and typically manifests chronically due to long-term maladaptive arterial growth and remodeling. To date, there is no in vitro technique for studying vascular function over relevant disease time courses that both mimics in vivo-like tissue structure and provides a s... | 25,245,868 | [
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[Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II)]. | The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting, held in Madrid in October 2013, resulting in this review, which is being p... | 25,245,875 | [
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Extensive thoracolumbosacral vertebral osteomyelitis after Lemierre syndrome. | To present a unique case of multilevel vertebral osteomyelitis after Lemierre syndrome. A previously healthy 27-year-old man presented in the Emergency Department in septic shock because of Lemierre syndrome for which he was subsequently treated with intravenous benzylpenicillin for 2 months. Two and a half months late... | 25,245,891 | [
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Solution mechanism guide: implementing innovation within a research & development organization. | In order to create a culture more open to novel problem-solving mechanisms, NASA's Human Health and Performance Directorate (HH&P) created a strategic knowledge management tool that educates employees about innovative problem-solving techniques, the Solution Mechanism Guide (SMG). The SMG is a web-based, interactiv... | 25,245,908 | [
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[Management of brain abscesses in era of computed tomography in sub-Saharan Africa: a review of 112 cases]. | The authors report a retrospective study conducted on 112 cases of cerebral abscesses collected over a period of 12 years from the medical records of the department of neurosurgery at the Yalgado Ouedraogo university teaching hospital, Ouagadougou-Burkina Faso. The analyses were conducted on the epidemiological, clinic... | 25,245,921 | [
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Iron and copper in male reproduction: a double-edged sword. | Iron and copper are essential trace nutrients playing important roles in general health and fertility. However, both elements are highly toxic when accumulating in large quantities. Their direct or indirect impact on the structure and function of male gonads and gametes is not completely understood yet. Excess or defic... | 25,245,929 | [
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Creativity and the default network: A functional connectivity analysis of the creative brain at rest. | The present research used resting-state functional magnetic resonance imaging (fMRI) to examine whether the ability to generate creative ideas corresponds to differences in the intrinsic organization of functional networks in the brain. We examined the functional connectivity between regions commonly implicated in neur... | 25,245,940 | [
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Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex. | DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these properties, we utilize single molecule DNA stretching to quantify both the binding affinity and the force-dependent threading intercalation kinetics of the binucl... | 25,245,944 | [
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Surviving cutaneous melanoma: a clinical review of follow-up practices, surveillance, and management of recurrence. | The number of melanoma survivors in the United States continues to steadily increase 2.6% per year, while death rates have remained stable over time. Although controversy exists regarding optimal surveillance strategies, recommendations for clinical monitoring are based on tumor stage, tumor phenotype, likelihood of re... | 25,245,963 | [
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Sitafloxacin: antimicrobial activity against ciprofloxacin-selected laboratory mutants of Mycoplasma genitalium and inhibitory activity against its DNA gyrase and topoisomerase IV. | A sitafloxacin regimen is highly effective on Mycoplasma genitalium infections, including those caused by the mycoplasmas harboring mutant topoisomerase IV with a quinolone resistance-associated amino acid change in ParC. In this study, we evaluated sitafloxacin antimicrobial activities against M. genitalium, including... | 25,245,990 | [
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Do fish perceive illusory motion? | Motion illusion refers to a perception of motion that is absent or different in the physical stimulus. These illusions are a powerful non-invasive tool for understanding the neurobiology of vision because they tell us, indirectly, how we process motion. There is general agreement in ascribing motion illusion to higher-... | 25,246,001 | [
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Vaccine resource tracking systems. | From 1999 to 2010, annual disbursements of development assistance for health for vaccinations increased from $0.5 billion to $2.0 billion (all financial values USD 2010). In its 2012 Global Vaccine Action Plan (GVAP), the World Health Assembly recommended establishing a comprehensive vaccination resource tracking syste... | 25,246,005 | [
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Benzodiazepine modulation of homomeric GABAAρ1 receptors: differential effects of diazepam and 4'-chlorodiazepam. | GABA(A) receptors (GABA(A)Rs) are ligand-gated ion channels that mediate inhibitory neurotransmission in the central nervous system (CNS). They are members of the Cys-loop receptor family and display marked structural and functional heterogeneity. Many GABA(A)Rs receptor subtypes are allosterically modulated by benzodi... | 25,246,015 | [
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The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases. | Complement factor H (FH) systemically inhibits excessive complement activation in the microenvironment of host cells, but for instance not on microbes. This self-recognition is mediated by two binding sites that recognize distinctly sulfated heparan sulfate (HS) domains. The interaction with HS not only concentrates FH... | 25,246,018 | [
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Total loss of Teeth in Adults, United States - 1960-1962. | Estimates of the prevalence and distribution of edentulous persons-men and women who have lost all of their natural teeth-are in essence statistical summaries reflecting both the amount and extent of dental disease and the failure to obtain prompt and adequate dental care. Toothdecay and periodontal disease-a degenerat... | 25,246,034 | [
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Behavior problems and timing of menarche: a developmental longitudinal biometrical analysis using the NLSY-Children data. | A powerful longitudinal data source, the National Longitudinal Survey of Youth Children data, allows measurement of behavior problems (BP) within a developmental perspective linking them to menarcheal timing (MT). In a preliminary analysis, we evaluate the bivariate relationships between BP measured at different develo... | 25,246,040 | [
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Value of imaging in head and neck tumors. | In this review, the value of imaging in the management of head and neck tumors is summarized. The many diverse tumors of the head and neck are grouped for purposes of staging and treatment. The groupings of malignancies consist of sinonasal, nasopharynx, salivary gland, oral cavity, oropharynx, hypopharynx, larynx, and... | 25,246,046 | [
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Image-guided interventions in oncology. | Interventional oncology, a term commonly used to indicate the minimally invasive procedures performed by interventional radiologists to diagnose and manage cancer, encompasses a broad spectrum of techniques unique to interventional radiology that have been established as a vital part of the multidisciplinary oncologic ... | 25,246,055 | [
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-0.2153668,
-0.2151534,
0.05743601,
0.04054825,
-0.002212653,
0.02558244,
-0.1262065,
-0.4594315,
-0.4284021,
-0.2341995,
-0.2843598,
0.1836958,
0.2067495,
-0.1149817,
0.1866969,
0.1541701,
-0.108826... |
Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway. | High expression levels of cyclooxygenase-2 (COX-2) contribute a strong proliferative ability to human lung cancer cells, and this function is link to the epidermal growth factor receptor (EGFR) pathway, which was mediated by extracellular-signal-regulated kinase (ERK) and nuclear factor kappa B (NFκB). In this study, s... | 25,246,059 | [
0.1126648,
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0.1682042,
0.2080757,
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0.290333,
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0.3807444,
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-0.08914067,
0.2532072,
0.4467625,
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0.1480525,
0.02363807,
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0.3649845,
0.07816231,
0.452199,
0.01115522,
0.2334051,
-0.01929478,
0.3... |
S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry. | Acetaminophen (APAP) hepatotoxicity is protected by S-adenosyl-l-methionine (SAMe) treatment 1hour (h) after APAP in C57/Bl6 mice. This study examined protein carbonylation as well as mitochondrial and cytosolic protein adduction by 4-hydroxynonenal (4-HNE) using mass spectrometry (MS) analysis. Additional studies inve... | 25,246,065 | [
-0.2511963,
0.1952966,
0.008856316,
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0.1428165,
0.01688816,
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0.04351001,
0.174809,
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0.1182551,
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0.3771065,
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0.1684319,
0.3499288,
-0.3303496,
-0.02165713,
-0.2460552,
... |
Het effect van galantamine op de ecg- geleidingstijden. | Galantamine, one of the acethylcholinesterase inhibitors (AChEI), is used in the treatment of Alzheimer's disease. However AChEI have been associated with adverse events, including cardiac events. The objective of this prospective, observational study is to evaluate the association between galantamine and incident card... | 25,246,067 | [
-0.2097748,
0.1074633,
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-0.04534613,
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-0.002518198,
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0.3740472,
0.3027436,
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0.2913914,
-0.4998513,
0.4211451,
0.1548588,
0.207064,
0.1492787,
0.2395684,
0.03017288,
... |
Phase resetting for a network of oscillators via phase response curve approach. | The problem of phase regulation for a population of oscillating systems is considered. The proposed control strategy is based on a phase response curve (PRC) model of an oscillator (the first-order reduced model obtained for linearized system and inputs with infinitesimal amplitude). It is proven that the control provi... | 25,246,107 | [
-0.009037571,
-0.07014883,
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0.1613238,
-0.3544655,
-0.2697464,
0.0314917,
0.2531646,
0.03008248,
0.02010322,
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0.2109966,
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0.007924023,
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0.2038727,
-0.2203403,
-0.08180745,
0.2361781,
-0.09862292,
-0.1098... |
Asymptomatic adenomyosis and embryo implantation in IVF cycles. | Research on the effect of adenomyosis on the rate of success of IVF is controversial. Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies. To establish whether embryo implantation is impaired in women with adenomyosis, wom... | 25,246,118 | [
-0.07907923,
0.1570726,
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0.2691417,
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0.1277005,
0.02205618,
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-0.3762658,
0.0958907,
-0.2160818,
-0.2112064,
0.1387855,
0.08705435,
-0.2670044... |
The effects of liraglutide on male fertility: a case report. | Liraglutide is an agonist of the glucagon-like peptide I receptor, and is commonly recommended as a treatment for obesity and type 2 diabetes mellitus. Adverse effects related to liraglutide include acute pancreatitis and polyarthritis. No studies, however, have reported an adverse effect of liraglutide on male reprodu... | 25,246,122 | [
0.05801562,
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0.01050847,
0.03954386,
0.1712014,
-0.0153022,
-0.07002143,
0.1319416,
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0.06566015,
0.1820156,
0.1607161,
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0.1473669,
0.1070299,
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-0.2862952,
0.1252124,
-0.1163613,
-0.514126,
-0.1597609,
0.2629472,
-0.3559892,
-... |
Effect of cognitive intervention on children with ADHD. | Although not considered a diagnostic criterion in DSM-IV, motor difficulties in children with Attention Deficit Hyperactivity Disorder (ADHD) are commonly reported. Prevalence of co-morbidity of ADHD and Developmental Coordination Disorder is as high as 50%. Cognitive Orientation to daily Occupational Performance (CO-O... | 25,246,134 | [
-0.2551903,
0.5167143,
0.03083399,
0.2143076,
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0.1276423,
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0.1324957,
0.1057659,
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0.01366062,
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-0.1229772,
-0.1443276,
0.1652916,
0.06734945,
... |
How I do it: combined direct (STA-MCA) and indirect (EDAS) EC-IC bypass. | EC-IC bypass for the treatment of a hypoperfused hemisphere is currently the treatment of choice for symptomatic moyamoya patients. Use of the combination of direct (STA-MCA) and indirect (an STA branch lay-on bypass and flipped dural flaps; EDAS) EC-IC bypass is advocated as the optimal treatment option as it allows i... | 25,246,144 | [
-0.03284192,
0.2281443,
0.01709258,
-0.4529217,
0.04608732,
-0.1524702,
-0.004480931,
-0.06937107,
-0.09425046,
-0.05332848,
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0.06810261,
-0.2160575,
-0.3893967,
-0.3162258,
0.05464441,
-0.5203983,
-0.1281383,
-0.007165472,
0.4097612,
0.2318206,
0.2775374,
-0... |
Variability in target delineation for cavernous sinus meningioma and anaplastic astrocytoma in stereotactic radiosurgery with Leksell Gamma Knife Perfexion. | Radiosurgery clinical practice relays on empirical observations and the experience of the practitioners involved in determining and delineating the target and therefore variability in target delineation might be expected for all the radiosurgery approaches, independent of the technique and the equipment used for delive... | 25,246,145 | [
-0.3277084,
0.2549961,
-0.09378152,
-0.02880258,
0.03872821,
-0.338037,
-0.1796337,
-0.4135277,
0.1095091,
0.1503553,
-0.00923135,
-0.2562457,
-0.1778628,
-0.3957807,
-0.2307163,
-0.01626396,
-0.4280697,
0.3907634,
-0.1906012,
0.07749196,
0.0004068495,
0.2532285,
0.309433... |
Metabolic syndrome - dysregulation of adipose tissue endocrine function. | Metabolic syndrome, acondition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying met... | 25,246,153 | [
-0.0701905,
-0.0473749,
0.05467017,
-0.2047753,
0.08725411,
-0.2229811,
0.1352361,
0.3808226,
0.2373282,
0.1464132,
-0.0541248,
-0.3880801,
-0.1045777,
-0.004946555,
-0.4726441,
-0.1774617,
-0.09635761,
-0.0625578,
0.1540028,
0.1378821,
0.04607402,
0.3324771,
-0.2652939,
... |
[Long-term adaptation of the patients to electrical stimulation in the course of rehabilitation following cochlear implantation]. | The objective of the present work was to study long-term adaptation of the patients to electrical stimulation in the course of rehabilitation following cochlear implantation. The following parameters were determined: variations of threshold auditory sensation of electrical stimulation (ESS), alteration of the maximum e... | 25,246,204 | [
-0.1456338,
-0.2146129,
-0.09939839,
0.1332554,
-0.2109085,
-0.4188662,
-0.277533,
0.04479908,
0.1435659,
0.1925333,
-0.02496217,
-0.3207841,
-0.2246611,
-0.2277446,
-0.1570163,
-0.1757783,
-0.3413472,
-0.02529483,
-0.2107903,
0.07221381,
0.1488905,
-0.1837341,
0.180298,
... |
Anterolateral thigh myocutaneous flaps as the preferred flaps for reconstruction of oral and maxillofacial defects. | The anterolateral thigh myocutaneous flap is one of the most commonly used flaps in reconstructive procedures, but its application in oral and maxillofacial defects has not been fully determined. Herein, we summarize the application of 1212 anterolateral thigh myocutaneous flaps in the repair of oral and maxillofacial ... | 25,246,225 | [
-0.2552761,
-0.09697137,
-0.280079,
-0.228382,
-0.01416991,
-0.1277661,
0.04416502,
0.390728,
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0.04788469,
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0.04257927,
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-0.03855012,
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-0.1764241,
0.2438975,
0.1389087,
0.2379531,
-0.1201645... |
Encoding order and developmental dyslexia: a family of skills predicting different orthographic components. | We investigated order encoding in developmental dyslexia using a task that presented nonalphanumeric visual characters either simultaneously or sequentially--to tap spatial and temporal order encoding, respectively--and asked participants to reproduce their order. Dyslexic participants performed poorly in the sequentia... | 25,246,235 | [
-0.2677044,
0.2192706,
-0.04152853,
-0.1455606,
0.3066895,
-0.5600125,
-0.1275894,
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0.04995294,
0.1856695,
0.1981793,
-0.3800038,
-0.1192483,
-0.7867665,
-0.02329391,
-0.4032804,
0.2980804,
-0.4581742,
-0.1007079,
0.3550514,
0.2000473,
-0.1219012,
... |
[Clinical characteristics of 192 adult hemophagocytic lymphohistiocytosis]. | To analyze the clinical manifestations, laboratory data, therapy, and prognosis in patients with hemophagocytic lymphohistiocytosis (HLH). A retrospective study was carried out in 192 adult patients with HLH between 2003 and 2013. Of the 192 cases, 70 cases were secondary to cancer and 64 cases secondary to infection. ... | 25,246,246 | [
0.1255386,
-0.1338141,
-0.05618147,
-0.4335066,
0.0402969,
-0.2572109,
-0.02427388,
0.1182305,
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0.3286682,
-0.01354506,
0.2899456,
0.2180167,
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-0.2976485,
-0.185059,
0.01270234,
0.2498997,
0.0447818,
0.7394343,
-0.03682559,
0.2243215,
-0.08566426,
... |
Reccurent bleeding from Meckel's diverticulum - surgeon's challenge. | The authors of this paper want to share their experience with diagnostic and therapeutic problems in case of chronic small intestinal bleeding from Meckel's diverticulum, which ended with acute episode of massive gastrointestinal bleeding requiring emergent surgery.Despite the progress achieved in diagnosing the source... | 25,246,290 | [
-0.1384214,
-0.09985519,
-0.103187,
-0.3518342,
0.05119799,
-0.213734,
-0.3022414,
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0.1251919,
-0.1680854,
0.27673,
0.3317101,
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0.01408649,
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-0.3532699,
0.02568044,
0.06454938,
0.1442926,
0.1993471,
0.03578776,
-0.2685899,
... |
X-linked Recessive Distal Myopathy With Hypertrophic Cardiomyopathy Caused by a Novel Mutation in the FHL1 Gene. | FHL1 gene mutations are associated with reducing body myopathy, X-linked myopathy with postural muscle atrophy, scapuloperoneal myopathy, Emery-Dreifuss muscular dystrophy, and isolated hypertrophic cardiomyopathy. We describe a boy with a family history consistent with X-linked distal myopathy/cardiomyopathy. The boy ... | 25,246,303 | [
-0.2333585,
0.1696955,
0.1244811,
-0.1842065,
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-0.0200753,
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0.03918363,
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0.1059492,
0.5396284,
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-0.5660937,
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-0.1854573,
0.195122,
-0.1911773,
... |
Comparison of Effects of Different Dexmedetomidine and Chloral Hydrate Doses Used in Sedation on Electroencephalography in Pediatric Patients. | The aim of this study was to compare the efficacy and safety of different oral chloral hydrate and dexmedetomidine doses used for sedation during electroencephalography (EEG) in children. One hundred sixty children aged 1 to 9 years with American Society of Anesthesiologists physical status I-II who were uncooperative ... | 25,246,305 | [
-0.112718,
0.02551387,
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0.2903527,
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0.1592579,
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-0.5933153,
0.2666146,
-0.2311678,
-0.09884265,
-0.1910716,
0.1440731,
-0.1749607,... |
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