title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Empathy and compassion. | As humans we are a highly social species: in order to coordinate our joint actions and assure successful communication, we use language skills to explicitly convey information to each other, and social abilities such as empathy or perspective taking to infer another person's emotions and mental state. The human cogniti... | 25,247,366 | [
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Robotics and neuroscience. | In the attempt to build adaptive and intelligent machines, roboticists have looked at neuroscience for more than half a century as a source of inspiration for perception and control. More recently, neuroscientists have resorted to robots for testing hypotheses and validating models of biological nervous systems. Here, ... | 25,247,370 | [
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Synthesis of fluorescent 2,3,5,6-tetraalkynylpyridines by site-selective Sonogashira-reactions of 2,3,5,6-tetrachloropyridines. | 4-Substituted 2,3,5,6-tetraalkynylpyridines were prepared by tetra-fold Sonogashira reactions of the corresponding 2,3,5,6-tetrachloropyridines. 2,6-Dialkynyl-3,5-dichloropyridines were prepared by site-selective Sonogashira reactions from various 4-unsubstituted and 4-substituted tetrachloropyridines. Subsequent two-f... | 25,247,374 | [
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Oxytetracycline, tetracycline, chlortetracycline and doxycycline in pasteurised cow's milk commercialised in Brazil. | The aim of this study was to investigate the presence of tetracycline residues in pasteurised cow's milk using high-performance liquid chromatography coupled with UV/VIS detection to determine the exposure of Brazilian's population to antibiotic residues. One hundred samples collected from the State of Paraná, Brazil, ... | 25,247,384 | [
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Multidetector CT measurement of myocardial extracellular volume in acute patchy and contiguous infarction: validation with microscopic measurement. | To provide proof of concept that expansion of myocardial extracellular volume (MECV), measured at contrast material-enhanced multidetector computed tomography (CT), can be used as a (a) marker for viability based on histologic confirmation and (b) predictor of severity of myocardial injury. Animals cared for in complia... | 25,247,406 | [
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New players driving inflammation in monogenic autoinflammatory diseases. | Systemic autoinflammatory diseases are caused by abnormal activation of the cells that mediate innate immunity. In the past two decades, single-gene defects in different pathways, driving clinically distinct autoinflammatory syndromes, have been identified. Studies of these aberrant pathways have substantially advanced... | 25,247,411 | [
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HIV disease progression in seroconvertors from the CAPRISA 004 tenofovir gel pre-exposure prophylaxis trial. | Although antiretroviral pre-exposure prophylaxis prevents HIV acquisition, it is not known if it alters HIV disease progression. This study assesses whether tenofovir gel impacted on disease progression among CAPRISA 004 microbicide trial seroconvertors. Eighty-three seroconvertors from the tenofovir and placebo gel ar... | 25,247,433 | [
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Disordered eating in obese individuals. | This article provides an overview of current thinking about the association between disordered eating and obesity, emphasizing binge eating, binge eating disorder and food addiction as useful conceptual models. Binge eating, recurrent and persistent episodes of overeating coupled with a lack of control over eating, and... | 25,247,456 | [
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Short and efficient synthesis of fluorinated δ-lactams. | The diastereoselective synthesis of fluorinated δ-lactams has been achieved through an efficient five step process. The route can tolerate a range of functionalities, and provides a quick route for the generation of new fluorinated medicinal building blocks. | 25,247,464 | [
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Kinetic and computational studies on Pd(I) dimer-mediated halogen exchange of aryl iodides. | Building on our previous discovery and reactivity explorations of the Pd(I) dimer [(PtBu3)PdBr]2-mediated halogen exchange of aryl iodides [Chem. Sci. 2013, 4, 4434], this report presents kinetic studies of this process, giving first-order kinetic dependence in the Pd(I) dimer and aryl iodide. An activation free energy... | 25,247,472 | [
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herg1b expression as a potential specific marker in pediatric acute myeloid leukemia patients with HERG 897K/K genotype. | Human ether-a-go-go related gene (herg) encoding HERG K(+) channel has been demonstrated in many previous studies with its association to cell cycle progression and growth in tumor cells. The upregulated expression of HERG K+ channels was determined in different tumor types. Furthermore, not only full-length transcript... | 25,247,487 | [
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Crack cocaine users show differences in genotype frequencies of the 3' UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3). | Due to the mechanism of action of the dopamine transporter (DAT) in drug addiction, the DAT1 gene is a potential candidate for molecular studies. This paper aims to compare the prevalence of allele and genotype frequencies created by the 3' UTR variable number of tandem repeats (VNTR) of this gene between crack cocaine... | 25,247,548 | [
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Use of insecticide-treated school uniforms for prevention of dengue in schoolchildren: a cost-effectiveness analysis. | Dengue-related illness is a leading cause of hospitalization and death, particularly among children. Practical, acceptable and affordable measures are urgently needed to protect this age group. Schools where children spend most of their day is proposed as an ideal setting to implement preventive strategies against day-... | 25,247,556 | [
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Case 210: Primary ovarian lymphoma. | History A 45-year-old woman presented with a 4-day history of abdominal discomfort, nausea, and vomiting and a 1-month history of poor appetite and weight loss. Her white blood cell count was normal. Physical examination revealed a palpable mass in the abdominopelvic region. Her cancer antigen (CA) 125 level was 1366 U... | 25,247,567 | [
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Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme. | The term "cryptome" refers to the subset of cryptic peptides with bioactivities that are often unpredictable and very different from the parent protein. These cryptic peptides are generated by proteolytic cleavage of proteases, whose identification in vivo can be very challenging. In this work, we show that insulin-deg... | 25,247,577 | [
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Pediatric invasive pneumococcal disease in Taiwan following a national catch-up program with the 13-valent pneumococcal conjugate vaccine. | Seven-valent pneumococcal conjugate vaccine (PCV) has been available in Taiwan since late 2005. A national catch-up program was launched in Taiwan in 2013, providing 1 dose of 13-valent PCV to children aged 2-5 years. Here, we report the epidemiology of invasive pneumococcal disease (IPD) in children aged ≤5 years in t... | 25,247,584 | [
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Reading performance is enhanced by visual texture discrimination training in Chinese-speaking children with developmental dyslexia. | High order cognitive processing and learning, such as reading, interact with lower-level sensory processing and learning. Previous studies have reported that visual perceptual training enlarges visual span and, consequently, improves reading speed in young and old people with amblyopia. Recently, a visual perceptual tr... | 25,247,602 | [
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Smart polymer nanoparticles for high-performance water-borne coatings. | Poly(butyl methacrylate) nanoparticles encapsulating a silica precursor, tetraethoxysilane (TEOS), were synthesized by a two-step emulsion polymerization process. We show that TEOS remains mostly unreacted inside the nanoparticles in water but acts both as a plasticizer and cross-linker in films cast from the dispersio... | 25,247,636 | [
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Working with adolescents and young adults to support transition. | Transition of medical care is a multifaceted, active process that attends to the medical, psychosocial, educational and vocational needs of adolescents and young adults as they move from child- to adult-centred care. Transition from paediatric to adult services is recognized as an important part of continuous care for ... | 25,247,650 | [
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Update on multiple sclerosis treatments. | Relapsing-remitting multiple sclerosis (RRMS) management has dramatically changed over the past decade. New drugs have arrived on the market, allowing for more individualised treatment selection. However, this diversity has increased the complexity of RRMS patient follow-up. In this review, we provide summarised inform... | 25,247,669 | [
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The role of resting state networks in focal neocortical seizures. | The role of resting state functional networks in epilepsy is incompletely understood. While some pathologic diagnoses have been shown to have maintained but altered resting state connectivity, others have implicated resting state connectivity in disease progression. However little is known about how these resting state... | 25,247,680 | [
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Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells. | The aging gene p66Shc, is an important mediator of oxidative stress-induced vascular dysfunction and disease. In cultured human aortic endothelial cells (HAEC), p66Shc deletion increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability via protein kinase B. However, the putative... | 25,247,687 | [
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Effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits. | The aim of the present study was to evaluate the effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits. New Zealand male albino rabbits (n 21) were divided into two groups: group 1 (G1; n 11), fed a hypercholesterolaem... | 25,247,699 | [
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3-Dimensional culture systems for anti-cancer compound profiling and high-throughput screening reveal increases in EGFR inhibitor-mediated cytotoxicity compared to monolayer culture systems. | 3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell culture and in vivo studies. To benefit anti-cancer drug discovery from 3D models, new techniques are needed that enable their use in high-throughput (HT) screening amenable formats. We have established miniaturized 3D culture... | 25,247,711 | [
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1,5-Diaminonaphthalene hydrochloride assisted laser desorption/ionization mass spectrometry imaging of small molecules in tissues following focal cerebral ischemia. | A sensitive analytical technique for visualizing small endogenous molecules simultaneously is of great significance for clearly elucidating metabolic mechanisms during pathological progression. In the present study, 1,5-naphthalenediamine (1,5-DAN) hydrochloride was prepared for matrix-assisted laser desorption/ionizat... | 25,247,713 | [
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Assessment of prosthesis alignment after revision total knee arthroplasty using EOS 2D and 3D imaging: a reliability study. | A new low-dose X-ray device, called EOS, has been introduced for determining lower-limb alignment in 2D and 3D. Reliability has not yet been assessed when using EOS on lower limbs containing a knee prosthesis. Therefore purpose of this study was to determine intraobserver and interobserver reliability of EOS 2D and 3D ... | 25,247,714 | [
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The effect of residual calcium hydroxide on the accuracy of a contemporary electronic apex locator. | The aim of this study was to evaluate the effect of residual calcium hydroxide [Ca(OH)2] on the accuracy of an electronic apex locator (EAL). Working lengths (WLs) of 56 extracted maxillary incisors were determined initially by two different methods. The first method used the 'APEX' reading of the EAL as a reference po... | 25,247,720 | [
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Maternally administered interventions for preterm infants in the NICU: effects on maternal psychological distress and mother-infant relationship. | Although studies have examined the effects of interventions focused on preterm infants, few studies have examined the effects on maternal distress (anxiety, depressive symptoms, post-traumatic stress symptoms, parenting stress) or parenting. This study examined the effects of the auditory-tactile-visual-vestibular (ATV... | 25,247,740 | [
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[Cost of Illness of HIV Patients under Anteretroviral Therapy in Germany - Results of the 48-Week Interim Analysis of the Prospective Multicentre Observational Study 'CORSAR']. | With the introduction of highly active combined antiretroviral therapy (c-ART) mortality and morbidity of HIV patients declined substantially. Earlier studies reported that c-ART was able to save health-care costs due to a reduction of other direct medical costs, particularly for inpatient treatments and concomitant me... | 25,247,761 | [
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Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease. | Periodontal inflammation is driven by the coordinated action of a number of factors, including the IL-1 family. Our study aimed to examine the levels of interleukin (IL)-36β, IL-36γ and IL-33 levels in gingival crevicular fluid (GCF) from patients with different periodontal diseases. A total of 80 subjects, 20 patients... | 25,247,780 | [
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Modelling the influence of photospheric turbulence on solar flare statistics. | Solar flares stem from the reconnection of twisted magnetic field lines in the solar photosphere. The energy and waiting time distributions of these events follow complex patterns that have been carefully considered in the past and that bear some resemblance with earthquakes and stockmarkets. Here we explore in detail ... | 25,247,788 | [
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A robust and accurate method for feature selection and prioritization from multi-class OMICs data. | Selecting relevant features is a common task in most OMICs data analysis, where the aim is to identify a small set of key features to be used as biomarkers. To this end, two alternative but equally valid methods are mainly available, namely the univariate (filter) or the multivariate (wrapper) approach. The stability o... | 25,247,789 | [
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A nutritional evaluation of dietary behaviour in various professional sports. | The types of physical exertion undertaken by weightlifters and race walkers markedly differ. This difference should also be reflected in their respective diets. The aim of the study was to investigate and assess the diets of professional weightlifters and race walkers, along with a comparison to the diets of those stud... | 25,247,803 | [
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Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. | Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible for the bioactivation of several exogenous pro-toxins including 4-ipomeanol (4-IPO). In contrast with the orthologous rabbit enzyme, we show here that native human CYP4B1 with a serine residue at position 427 is unable to bioactivate 4-IP... | 25,247,810 | [
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Retrospective review of lung cancers diagnosed in annual rounds of CT screening. | The purpose of this study was to review the records of patients with diagnoses of lung cancer in annual repeat rounds of CT screening in the International Early Lung Cancer Action Program to determine whether the cancer could have been identified in the previous round of screening. Three radiologists reviewed the scans... | 25,247,825 | [
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Inflammation and endometrial bleeding. | Most of the key physiological processes in the human reproductive tract involve a significant inflammatory component. These processes include follicle development, ovulation, implantation, pregnancy, labor, postpartum, remodeling and menstruation. In this context, the term 'inflammation' usually means an influx of leuk... | 25,247,830 | [
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High-resolution ultrasonic spectroscopy study of interactions between hyaluronan and cationic surfactants. | Interactions in a cationic surfactant-hyaluronan system in water and in sodium chloride solution were investigated by high-resolution ultrasonic spectroscopy at 25 °C. Two alkyltrimethylammonium bromide surfactants of different chain lengths (tetradecyl and hexadecyl) were used; hyaluronan molecular weight ranged from ... | 25,247,835 | [
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Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. | Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid mediators. PD1 (3) is a natural product that displays potent anti-inflammatory properties together with... | 25,247,845 | [
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Does long time spending on the electronic devices affect the reading abilities? A cross-sectional study among Chinese school-aged children. | Home literacy environment (HLE) is one of most important modifiable risk factors to dyslexia. With the development in technology, we include the electronic devices usage at home, such as computers and televisions, to the definition of HLE and investigate its impact on dyslexia based on the on-going project of Tongji's ... | 25,247,847 | [
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Preoperative low-dose steroid can prevent respiratory insufficiency after thymectomy in generalized myasthenia gravis. | Postoperative respiratory insufficiency (PRI) in myasthenia gravis (MG) often occurs within several days after thymectomy and remains problematic. In limited studies reporting that preoperative steroids prevented PRI in patients with MG, high doses of steroids were used and detailed information on the use of steroids i... | 25,247,848 | [
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Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors. | Resistance to temozolomide (TMZ) based chemotherapy in glioblastoma multiforme (GBM) has been attributed to the upregulation of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). Inhibition of MGMT using O(6)-benzylguanine (BG) has shown promise in these patients, but its clinical use is hindered b... | 25,247,850 | [
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Comparing i-Tree modeled ozone deposition with field measurements in a periurban Mediterranean forest. | Ozone flux estimates from the i-Tree model were compared with ozone flux measurements using the Eddy Covariance technique in a periurban Mediterranean forest near Rome (Castelporziano). For the first time i-Tree model outputs were compared with field measurements in relation to dry deposition estimates. Results showed ... | 25,247,877 | [
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Termination chemistry-driven dislocation structure at SrTiO3/MgO heterointerfaces. | Exploiting the promise of nanocomposite oxides necessitates a detailed understanding of the dislocation structure at the interfaces, which governs diverse and technologically relevant properties. Here we report atomistic simulations demonstrating a strong dependence of the dislocation structure on the termination chemi... | 25,247,885 | [
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The neurosurgical treatment of Alzheimer's disease: a review. | Alzheimer's disease (AD) is a debilitating neurological illness of increasing prevalence. Because many patients are affected and current treatments have limited effectiveness, other therapeutic strategies are urgently needed. Here we provide a review of the neurosurgical approaches that have been attempted or are curre... | 25,247,891 | [
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Prevalence of low back pain in Latin America: a systematic literature review. | Chronic low back pain is considered as a high-impact condition that affects the working population of Latin America, with long reaching social and economic repercussions. Its true frequency is unknown due to the absence of well-designed clinical trials that use standardized definitions and criteria. To evaluate the pre... | 25,247,896 | [
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Catheter-based treatments for hepatic metastases from neuroendocrine tumors. | The purpose of this article is to present our experience in treating patients with hepatic metastases from a neuroendocrine primary malignancy. The tumor and patient characteristics, vascular access, and features of treatment all play a role in the long-term management of patients with metatastic neuroendocrine tumors.... | 25,247,935 | [
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Metal artifact reduction software used with abdominopelvic dual-energy CT of patients with metal hip prostheses: assessment of image quality and clinical feasibility. | The objective of our study was to determine the feasibility of using Metal Artifact Reduction (MAR) software for abdominopelvic dual-energy CT in patients with metal hip prostheses. This retrospective study included 33 patients (male-female ratio, 19:14; mean age, 63.7 years) who received total hip replacements and 20 ... | 25,247,944 | [
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Transverse sinus stenosis in adult patients with Chiari malformation type I. | Transverse sinus stenosis is an imaging finding very highly associated with elevated intracranial pressure (ICP). Patients with the Chiari I malformation may potentially have elevated ICP due to impairment of CSF flow at the foramen magnum. This study evaluated whether patients with Chiari I malformation have transvers... | 25,247,957 | [
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Prognostic value of FDG PET metabolic tumor volume in human papillomavirus-positive stage III and IV oropharyngeal squamous cell carcinoma. | The purpose of this study was to establish the prognostic utility in human papillomavirus (HPV)-positive stage III and IV oropharyngeal squamous cell carcinoma (SCC) of the (18)F-FDG parameters maximal, mean, and peak standardized uptake value (SUVmax, SUVmean, and SUVpeak, respectively); metabolic tumor volume (MTV); ... | 25,247,958 | [
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Lymphoid nodular hyperplasia of the terminal ileum can mimic active crohn disease on MR enterography. | The purpose of this article is to describe the MRI findings associated with lymphoid nodular hyperplasia at MR enterography and test the ability of radiologists to differentiate healthy control subjects from patients with Crohn disease (CD). Ethical approval was granted for this retrospective study. Thirty-five subject... | 25,247,969 | [
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In-phase signal intensity loss in solid renal masses on dual-echo gradient-echo MRI: association with malignancy and pathologic classification. | The purposes of this study were to determine the prevalence of in-phase signal intensity loss on dual-echo gradient-echo MRI in solid renal masses using visual and quantitative techniques and to test for any association between in-phase signal intensity loss and pathologic classification. The renal MRI studies of 177 p... | 25,247,971 | [
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Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study. | Potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) gene have a key role in insulin secretion and is of substantial interest as a candidate gene for type 2 diabetes (T2D). The current work was performed to delineate the genetic influence of KCNJ11 polymorphisms on risk of T2D in South Indian populati... | 25,247,988 | [
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Species richness and evidence of random patterns in assemblages of South American Titanosauria during the Late Cretaceous (Campanian-Maastrichtian). | The Titanosauria were much diversified during the Late Cretaceous, but paleobiological information concerning these sauropods continues to be scarce and no studies have been conducted utilizing modern methods of community analysis to infer possible structural patterns of extinct assemblages. The present study sought to... | 25,247,998 | [
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RGDechi-hCit: αvβ3 selective pro-apoptotic peptide as potential carrier for drug delivery into melanoma metastatic cells. | αvβ3 integrin is an important tumor marker widely expressed on the surface of cancer cells. Recently, we reported some biological features of RGDechi-hCit, an αvβ3 selective peptide antagonist. In the present work, we mainly investigated the pro-apoptotic activity of the molecule and its ability to penetrate the membra... | 25,248,000 | [
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... |
Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+coproducing CD4+ T cells in active inflammatory bowel disease. | Skewed T helper (TH) cell responses and specific functions of TH1, TH2, TH17, and Treg cells have been implicated in the pathogenesis of inflammatory bowel disease (IBD) that led to the establishment of the pathogenic TH1/TH2 and TH17/Treg cell imbalance paradigms. However, the relevant TH cell population driving mucos... | 25,248,005 | [
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Poor Validity of the DSM-IV Schizoid Personality Disorder Construct as a Diagnostic Category. | This study sought to evaluate the construct validity of schizoid personality disorder (SZPD) by investigating a sample of 2,619 patients from the Norwegian Network of Personality-Focused Treatment Programs by a variety of statistical techniques. Nineteen patients (0.7%) reached the diagnostic threshold of SZPD. Results... | 25,248,009 | [
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Steroid regulation of T cell function appears unaltered in borderline personality disorder. | Borderline personality disorder (BPD) is characterized by instability of interpersonal relationships and affection, impulsivity, and cognitive disruptions. Increasing evidence suggests hypothalamic-pituitary-adrenal (HPA) axis alterations in BPD. Changed glucocorticoid sensitivity of peripheral blood mononuclear cells ... | 25,248,018 | [
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Engineering 3D bio-artificial heart muscle: the acellular ventricular extracellular matrix model. | Current therapies in left ventricular systolic dysfunction and end-stage heart failure include mechanical assist devices or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option that overcomes the limitations associated with current treatment modalities. This study p... | 25,248,038 | [
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Particle embolization for the treatment of life-threatening epistaxis in a left ventricular assist device patient. | While epistaxis is self-limiting in most cases, patients who are anticoagulated are at increased risk for life-threatening hemorrhage. The management of epistaxis in patients with a left ventricular assist device is further complicated by an increased risk for hemodynamic instability. Here, we detail the successful tre... | 25,248,039 | [
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Default network connectivity is linked to memory status in multiple sclerosis. | Memory impairment affects 50% of multiple sclerosis (MS) patients. Altered resting-state functional connectivity (FC) has been observed in the default network (DN) of MS patients. No study to date has examined the association of DN FC to its behavioral concomitant, memory. The approach of the present study represents a... | 25,248,054 | [
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Urinary tract infection in elderly trauma patients: review of the Trauma Quality Improvement Program identifies the population at risk. | Elderly trauma patients are at high risk for urinary tract infection (UTI). Despite this, UTI has been deemed a potentially preventable problem and therefore not reimbursable by the Centers for Medicare and Medicaid Services. Early identification of UTI in these patients should lead to prompt treatment, improved outcom... | 25,248,065 | [
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Integrating diffusion tensor imaging-based tractography into deep brain stimulation surgery: a review of the literature. | It has been generally accepted that deep brain stimulation (DBS) not only acts in the nucleus where it is being applied, as initially thought, but that chronic stimulation activates axons located in its scope, and that this activation can exert its effects in distant areas. Considering this, DBS target identification s... | 25,248,076 | [
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Evaluation of BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to first-line drugs in China. | The purpose of this study was to evaluate the performance of the BACTEC MGIT 960 (M960) system compared with the proportion method (PM) on Löwenstein-Jensen (L-J) medium in a peripheral laboratory in China for the testing of Mycobacterium tuberculosis (MTB) susceptibility to streptomycin (SM), isoniazid (INH) rifampici... | 25,248,118 | [
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0.1000248,
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0.3150582,
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Current trends in research and clinical issues in the study of personality and its disorders: a survey of the presentations at the ISSPD anniversary congress. | The International Society for the Study of Personality Disorders (ISSPD) celebrated its 25th anniversary in September 2013 in Copenhagen and commemorated the First International Congress at the same site. The overall theme of the congress was "Bridging Personality and Psychopathology: The Person Behind the Illness." Mo... | 25,248,121 | [
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N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression. | Chromium hypersensitivity (chromium-induced allergic contact dermatitis) is an important issue in occupational skin disease. Hexavalent chromium (Cr (VI)) can activate the Akt, Nuclear factor κB (NF-κB), and Mitogen-activated protein kinase (MAPK) pathways and induce cell death, via the effects of reactive oxygen speci... | 25,248,126 | [
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Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates. | Numerous studies have demonstrated the efficacy of the Adeno-Associated Virus (AAV)-based gene delivery platform in vivo. The control of transgene expression in many protocols is highly desirable for therapeutic applications and/or safety reasons. To date, the tetracycline and the rapamycin dependent regulatory systems... | 25,248,159 | [
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Automatic deformable MR-ultrasound registration for image-guided neurosurgery. | In this work, we present a novel algorithm for registration of 3-D volumetric ultrasound (US) and MR using Robust PaTch-based cOrrelation Ratio (RaPTOR). RaPTOR computes local correlation ratio (CR) values on small patches and adds the CR values to form a global cost function. It is therefore invariant to large amounts... | 25,248,177 | [
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Optimal transition probability of reversible data hiding for general distortion metrics and its applications. | Recently, a recursive code construction (RCC) approaching the rate-distortion bound of reversible data hiding (RDH) was proposed. However, to estimate the rate-distortion bound or execute RCC, one should first estimate the optimal transition probability matrix (OTPM). By previous methods, OTPM can be effectively estima... | 25,248,187 | [
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A multiple-feature and multiple-kernel scene segmentation algorithm for humanoid robot. | This technical correspondence presents a multiple-feature and multiple-kernel support vector machine (MFMK-SVM) methodology to achieve a more reliable and robust segmentation performance for humanoid robot. The pixel wise intensity, gradient, and C1 SMF features are extracted via the local homogeneity model and Gabor f... | 25,248,211 | [
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A survey on bimanual haptic interaction. | When interacting with virtual objects through haptic devices, most of the time only one hand is involved. However, the increase of computational power, along with the decrease of device costs, allow more and more the use of dual haptic devices. The field which encompasses all studies of the haptic interaction with eith... | 25,248,213 | [
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[Antibodies against alfa-enolase as an indication of inflammatory process in patients with celiac disease--preliminary results]. | Celiac disease (CD) is an autoimmunological gluten sensitive enteropathy occuring to genetically predisposed individuals. Active CD is accompanied by presence of multiple antibodies. Anti alpha enolase antibodies were reported in several autoimmunological disorders like rheumatoid arthritis, primary sclerosing cholangi... | 25,248,239 | [
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[Atypical BCR-ABL transcripts in patients with chronic myeloid leukemia--the scheme for the diagnosis and monitoring of minimal residual disease]. | More than 95% of patients with detected translocation t(9;22), is characterized by the fusion between exons e13 or e14 of BCR gene, which are located in major breakpoint cluster region (M-bcr) and exon a2 of ABL gene. These fusions are described as b2a2 (e13a2) and b3a2 (e14a2). Other fusions of exons e1, e6, e8, e12, ... | 25,248,240 | [
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[Syndrome of inappropriate secretion of antidiuretic hormone]. | Hyponatremia is a commonly encountered electrolyte abnormality in clinical practice and in some groups of patients is associated with significant morbidity and mortality. Although the pathophysiology of this disturbance is complex, its understanding is vital to the disorder's evaluation and treatment. The syndrome of i... | 25,248,244 | [
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[The observation and analysis the function and morphology of the eustachian tube in secretory otitis media and chronic rhinosinusitis in children]. | To observe and analyze the function and morphology of pharyngeal ostium of the eustachian tubes in secretory otitis media and chronic rhinosinusitis in children under direct vision,in order to provide an objective basis for clinical treatments. Fifty cases of secretory otitis media,50 cases of chronic rhinosinusitis an... | 25,248,251 | [
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[Expression of IL-35, Epstein-Barr virus-induced gene 3 mRNA and IL-12A mRNA in peripheral blood of patients with allergic rhinitis]. | To explore the expression of IL-35, Epstein-Barr virus-induced gene 3 (EBI3) mRNA and IL-12A mRNA in peripheral blood of patients with allergic rhinitis and its significance. Peripheral blood were collected from patients with allergic rhinitis (46 cases) and healthy human controls(30 cases). The level of IL-35 in serum... | 25,248,258 | [
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Diagnostic tools for alzheimer's disease dementia and other dementias: an overview of diagnostic test accuracy (DTA) systematic reviews. | Dementia includes a group of neurodegenerative disorders characterized by progressive loss of cognitive function and a decrease in the ability to perform activities of daily living. Systematic reviews of diagnostic test accuracy (DTA) focus on how well the index test detects patients with the disease in terms of figure... | 25,248,284 | [
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Influence of the tourniquet on tibial cement mantle thickness in primary total knee arthroplasty. | The purpose of the study was whether the use of a tourniquet increases cement mantle thickness in primary total knee arthroplasty and influences the calculated blood loss and postoperative pain. Ninety patients with a primary total knee arthroplasty (TKA) were enroled in this prospective randomised trial and divided in... | 25,248,311 | [
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Uptake of the antisecretory factor peptide AF-16 in rat blood and cerebrospinal fluid and effects on elevated intracranial pressure. | AF-16 is a 16-amino-acid-long peptide derived from the amino-terminal part of the endogenous protein, antisecretory factor (AF). AF-16 in vivo has been shown to regulate dysfunctions in the water and ion transport system under various pathological conditions and also to counteract experimentally increased tissue pressu... | 25,248,325 | [
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Measuring and optimizing results in multipolar RFA: Techniques and early findings in an experimental setting. | Radiofrequency ablation (RFA) has shown to be a reasonable alternative for the treatment of hepatic tumors and metastases although multiple limitations remain. Cooling effects due to larger vessels can prevent complete coverage and may lead to early tumor relapse. This preliminary in vivo pig study combines the use of ... | 25,248,350 | [
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In a class of their own: the Danish public considers obesity less deserving of treatment compared with smoking-related diseases. | This study examined public support for publicly funded treatment of obesity (weight-loss surgery and medical treatment) and two pulmonary diseases (chronic obstructive pulmonary disease (COPD) and lung cancer) in Denmark. It also investigated whether beliefs about the causes of lifestyle-related diseases (external envi... | 25,248,357 | [
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Screening travellers to high-endemic countries for infection with Mycobacterium tuberculosis using interferon gamma release assay; a prospective study. | International travel from low-incidence to high-incidence countries for tuberculosis (TB) is regarded as a risk factor for acquiring TB infection. In this prospective study among long-term travellers we examined the incidence of TB infection using Interferon gamma release assay (IGRA) test and compared these data with ... | 25,248,372 | [
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... |
Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice. | Biological drugs are effective in patients with rheumatoid arthritis (RA), but increase severe infections. The CC chemokine receptor (CCR) 9 antagonist was effective for Crohn's disease without critical adverse effects including infections in clinical trials. The present study was carried out to explore the pathogenic ... | 25,248,373 | [
0.03179613,
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-0.0880494,
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0.03665094,
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0.3548654,
0.3365259,
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0.0007356607,
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0.1143697,
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0.5016726,
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0.1769353,
-0.012084... |
Fibroblast Growth Factor-2 alone as an efficient inducer for differentiation of human bone marrow mesenchymal stem cells into dopaminergic neurons. | The reported efficiency of differentiation of human bone marrow derived Mesenchymal Stem Cells (hBM MSC) into dopaminergic neurons with different inducers is found to vary. Thus, in the current study we have investigated the response of hBM MSC to some of the neuronal inducers and their combinations. Neuronal different... | 25,248,378 | [
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Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (bolus) infusion schedule of alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms. | This phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for the combination of bortezomib and alvocidib in patients with B-cell malignancies (multiple myeloma, indolent lymphoma, Waldenstrom macroglobulinemia, and mantle cell lymphoma). Patients received bortezo... | 25,248,382 | [
-0.1687821,
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0.03881585,
0.1325557,
-0.04332123,
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0.1063948,
0.1... |
Simulation and comparison of progression-free survival among patients with non-squamous non-small-cell lung cancer receiving sequential therapy. | In recent years, the treatment landscape in advanced non-squamous non-small-cell lung cancer (nsNSCLC) has changed. New therapies (e.g., bevacizumab indicated in first line) have become available and other therapies (e.g., pemetrexed in first line and second line) moved into earlier lines in the treatment paradigm. Whi... | 25,248,391 | [
-0.1388736,
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0.3008745,
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0.2376398,
0.5520527,
0.3241779,
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... |
International Charter of principles for sharing bio-specimens and data. | There is a growing international agreement on the need to provide greater access to research data and bio-specimen collections to optimize their long-term value and exploit their potential for health discovery and validation. This is especially evident for rare disease research. Currently, the rising value of data and ... | 25,248,399 | [
-0.06631546,
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0.2189794,
0.07572536,
0.270088,
-0.46180... |
International precipitants to psychiatric patient assaults in community settings: review of published findings, 2000-2012. | In studying psychiatric patient assaults, assessing the person × event × environment interaction is important in enhancing safety and ensuring quality care. Precipitants to patient assaults have traditionally received less attention than the characteristics of such assaults. A recent review of inpatient precipitants no... | 25,248,419 | [
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-0.2800681,
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0.1838633,
-0.0937... |
Classification of Physiological 18F-fluorodeoxyglucose Uptake in the Large Intestine: a Preliminary Study. | Varying degrees of physiological uptake of 18F-fluorodeoxyglucose (FDG) are often noted in the large intestine and can be problematic when interpreting positron emission tomography (PET) images. In relation to colorectal tumor detection with FDG PET, we tentatively classified physiological FDG uptake in the large intes... | 25,248,430 | [
-0.2856134,
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0.401356,
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0.3984729,
-0.00719509,... |
The phenomenon of micronutrient deficiency among children in China: a systematic review of the literature. | The present study aimed to review the literature on micronutrient deficiency and other factors influencing a deficiency status among children living in China. A systematic review was performed to analyse the literature. Studies were identified through a search of PubMed and secondary references. Children living in Chin... | 25,248,458 | [
-0.2372232,
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0.0256434,
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0.2144699,
0.131097,
0.55976,
-0.5142239,
0.3... |
Trimodality bladder-sparing approach without neoadjuvant chemotherapy for node-negative localized muscle-invasive urinary bladder cancer resulted in comparable cystectomy-free survival. | To retrospectively review the efficacy and organ preservation experience for muscle-invasive bladder cancer by trimodality therapy at our institution. Between July 2004 and February 2012, seventy patients (M/F = 55/15; median age = 69 years) of lymph node negative localized muscle-invasive bladder cancer were treated p... | 25,248,470 | [
-0.1403893,
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0.1956246,
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0.370926,
0.06252355,
... |
Usefulness of endoluminal catheter colonization surveillance cultures to reduce catheter-related bloodstream infections in hemodialysis. | To evaluate the use of surveillance cultures (SCs) to prevent catheter-related bloodstream infections (CRBSIs) in asymptomatic hemodialysis (HD) patients. In 2011-2012, we conducted a prospective study of HD patients with tunneled cuffed central venous catheters (TCCs). Colonization of the catheter lumen was assessed e... | 25,248,485 | [
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0.03253845,
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0.09487592,
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0.3939462,
0.0274157... |
Disentangling quality and safety indicator data: a longitudinal, comparative study of hand hygiene compliance and accreditation outcomes in 96 Australian hospitals. | The study aims are twofold. First, to investigate the suitability of hand hygiene as an indicator of accreditation outcomes and, second, to test the hypothesis that hospitals with better accreditation outcomes achieve higher hand hygiene compliance rates. A retrospective, longitudinal, multisite comparative survey. Acu... | 25,248,496 | [
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0.004810912,
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-0.07610344,
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... |
Employment outcomes one year after bariatric surgery: the role of patient and psychosocial factors. | Patients undergoing bariatric surgery generally report improved work performance after this procedure; however, previous research has been limited by a lack of standardized employment measures and a failure to account for the impact of psychiatric illness on employment outcomes. To address these limitations, this study... | 25,248,509 | [
0.2608656,
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-0.07519213,
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0.02268253,
0.2286252,
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-0.6467046,
0.09065341,
-0.0537191... |
Prevalence, causes and consequences of compassion satisfaction and compassion fatigue in emergency care: a mixed-methods study of UK NHS Consultants. | To estimate prevalence and explore potential causes and consequences of compassion satisfaction and compassion fatigue in UK emergency medicine consultants. A sequential mixed-methods design. Cross-sectional e-survey to all UK NHS emergency medicine consultants (n=1317) including Professional Quality of Life (ProQOL) (... | 25,248,545 | [
0.07681677,
0.1704618,
0.1379542,
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0.03366372,
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0.1969578,
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0.1453013,
0.04089158,
... |
Bone quality is affected by food restriction and by nutrition-induced catch-up growth. | Growth stunting constitutes the most common effect of malnutrition. When the primary cause of malnutrition is resolved, catch-up (CU) growth usually occurs. In this study, we have explored the effect of food restriction (RES) and refeeding on bone structure and mechanical properties. Sprague-Dawley male rats aged 24 da... | 25,248,555 | [
0.3211135,
0.07466987,
0.1490946,
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0.3261128,
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0.3242116,
-0.3837216,
0.2316041,
-0.17296... |
Elucidating dimensions of posttraumatic stress symptoms and their functional correlates in disaster-exposed adolescents. | The aim of this study was to elucidate the dimensional structure of posttraumatic stress disorder (PTSD) and potential moderators and functional correlates of this structure in disaster-affected adolescents. A population-based sample of 2000 adolescents aged 12-17 years (M = 14.5 years; 51% female) completed interviews... | 25,248,557 | [
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0.1287861,
0.02792029,
0.26552,
0.1487967,
0.1320346,
-0.2194481,
0.... |
One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death. | Caesalpinia sappan is a well-distributed plant that is cultivated in Southeast Asia, Africa, and the Americas. C. sappan has been used in Asian folk medicine and its extract has been shown to have pharmacological effects. Two homoisoflavonoids, sappanol and brazilin, were isolated from C. sappan by using centrifugal pa... | 25,248,564 | [
0.03957649,
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-0.04940737,
0.1810283,
0.2059238,
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0.1760083,
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0.4010239,
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0.03335546,
0.04090674,
0.005006337,
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0.1807142,
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0.04686868,
0.226519,
0.04616... |
Genetic aspects of hypothalamic and pituitary gland development. | Hypothalamo-pituitary development during embryogenesis is a highly complex process involving the interaction of a network of spatiotemporally regulated signaling molecules and transcription factors. Mutations in any of the genes encoding these components can lead to congenital hypopituitarism, which is often associated... | 25,248,576 | [
0.0006291224,
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0.3394491,
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0.02741636,
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0.1123863,
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0.02550606,
0.3936172,
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0.1259851,
0.1826253,
-0.05598781,
... |
Craniopharyngioma. | Craniopharyngiomas are partly cystic embryogenic malformations of the sellar and parasellar region. With an overall incidence of 0.5-2.0 new cases per million population per year, approximately 30-50% of all cases represent childhood craniopharyngioma. Typical manifestations at diagnosis are some combination of headach... | 25,248,591 | [
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0.4168132,
0.1874225,
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0.006557197,
0.4397249,
-0.180896... |
A decisional account of subjective inflation of visual perception at the periphery. | Human peripheral vision appears vivid compared to foveal vision; the subjectively perceived level of detail does not seem to drop abruptly with eccentricity. This compelling impression contrasts with the fact that spatial resolution is substantially lower at the periphery. A similar phenomenon occurs in visual attentio... | 25,248,620 | [
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0.3094751,
-0.2782886,
0.01246927,
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0.3738604,
0.1419376,
-... |
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