title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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2-[(4,6-Di-amino-pyrimidin-2-yl)sulfan-yl]-N-(2-methyl-phen-yl)acetamide. | In the title compound, C13H15NOS, the plane of the pyrimidine ring makes a dihedral angle of 54.73 (9)° with that of the o-tolyl ring. The mol-ecule adopts an extended conformation, which is evident from the C-C(=O)-N-Car (ar = aromatic) torsion angle of 178.42 (15)°. In the crystal, mol-ecules are linked via pairs of ... | 25,249,901 | [
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4-(2-Nitro-benz-yl)-3-phenyl-3,4-di-hydro-2H-1,4-benzoxazin-2-ol. | The title compound, C21H18N2O4, crystallizes with two independent mol-ecules (A and B) in the asymmetric unit. In both mol-ecules the oxazine ring has an envelope conformation with the hydroxyl-substituted C atom as the flap. The nitro-benzyl ring and the phenyl ring are almost normal to the mean plane of the benzooxaz... | 25,249,912 | [
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Methyl 4-amino-2-chloro-pyrimidine-5-carboxyl-ate. | In the title compound, C6H6ClN3O2, all non-H atoms are approximately coplanar [maximum deviation = 0.012 (4) Å]; an intra-molecular N-H⋯O hydrogen bond occurs between the amino group and the carbonyl group. In the crystal, mol-ecules are linked by N-H⋯N hydrogen bonds into supra-molecular chains propagated along [101].... | 25,249,916 | [
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C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation. | Traumatic brain injury (TBI) induces a strong inflammatory response which includes blood-brain barrier damage, edema formation and infiltration of different immune cell subsets. More recently, microvascular thrombosis has been identified as another pathophysiological feature of TBI. The contact-kinin system represents ... | 25,249,935 | [
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Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance. | The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several tissues, including liver, pancreas, lung, prostate, and the neural system. Both Foxa1 and Foxa2 are also crucial for the specification and differentiation of dopamine (DA) neurons during em... | 25,249,938 | [
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The left side of motor resonance. | Motor resonance is defined as the internal activation of an observer's motor system, specifically attuned to the perceived movement. In social contexts, however, different patterns of observed and executed muscular activation are frequently required. This is the case, for instance, of seeing a key offered with a precis... | 25,249,966 | [
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Synaptic bouton properties are tuned to best fit the prevailing firing pattern. | The morphology of presynaptic specializations can vary greatly ranging from classical single-release-site boutons in the central nervous system to boutons of various sizes harboring multiple vesicle release sites. Multi-release-site boutons can be found in several neural contexts, for example at the neuromuscular junct... | 25,249,970 | [
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Object recognition with hierarchical discriminant saliency networks. | The benefits of integrating attention and object recognition are investigated. While attention is frequently modeled as a pre-processor for recognition, we investigate the hypothesis that attention is an intrinsic component of recognition and vice-versa. This hypothesis is tested with a recognition model, the hierarchi... | 25,249,971 | [
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Short-term dynamics of causal information transfer in thalamocortical networks during natural inputs and microstimulation for somatosensory neuroprosthesis. | Recording the activity of large populations of neurons requires new methods to analyze and use the large volumes of time series data thus created. Fast and clear methods for finding functional connectivity are an important step toward the goal of understanding neural processing. This problem presents itself readily in ... | 25,249,973 | [
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Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia. | The last several decades have seen intensive research into the molecular mechanisms underlying the symptoms of preeclampsia. While the underlying cause of preeclampsia is believed to be defective placental development and resulting placental ischemia, it is only recently that the links between the ischemic placenta and... | 25,249,978 | [
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The relationship between nature connectedness and happiness: a meta-analysis. | Research suggests that contact with nature can be beneficial, for example leading to improvements in mood, cognition, and health. A distinct but related idea is the personality construct of subjective nature connectedness, a stable individual difference in cognitive, affective, and experiential connection with the natu... | 25,249,992 | [
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The componential processing of fractions in adults and children: effects of stimuli variability and contextual interference. | Recent studies have indicated that people have a strong tendency to compare fractions based on constituent numerators or denominators. This is called componential processing. This study explored whether componential processing was preferred in tasks involving high stimuli variability and high contextual interference, w... | 25,249,995 | [
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Investigating executive functions in children with severe speech and movement disorders using structured tasks. | Executive functions are the basis for goal-directed activity and include planning, monitoring, and inhibition, and language seems to play a role in the development of these functions. There is a tradition of studying executive function in both typical and atypical populations, and the present study investigates executi... | 25,249,999 | [
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The lethal cargo of Myxococcus xanthus outer membrane vesicles. | Myxococcus xanthus is a bacterial micro-predator known for hunting other microbes in a wolf pack-like manner. Outer membrane vesicles (OMVs) are produced in large quantities by M. xanthus and have a highly organized structure in the extracellular milieu, sometimes occurring in chains that link neighboring cells within ... | 25,250,022 | [
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Injury and immune response: applying the danger theory to mosquitoes. | The insect immune response can be activated by the recognition of both non-self and molecular by-products of tissue damage. Since pathogens and tissue damage usually arise at the same time during infection, the specific mechanisms of the immune response to microorganisms, and to tissue damage have not been unraveled. C... | 25,250,040 | [
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Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases. | Advances in research and technology has increased our quality of life, allowed us to combat diseases, and achieve increased longevity. Unfortunately, increased longevity is accompanied by a rise in the incidences of age-related diseases such as Alzheimer's disease (AD). AD is the sixth leading cause of death, and one o... | 25,250,042 | [
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Shunt malfunction presenting with symptomatic syringomyelia: Demonstrated on contrast ventriculogram. | Ventriculoperitoneal (VP) shunt malfunction commonly presents as raised intracranial pressure. Rarely, when the central canal of the spinal cord communicates with the 4(th) ventricle, shunt malfunction can present as an expanding syrinx. The diagnosis is often delayed, resulting in severe morbidity. Some of these patie... | 25,250,067 | [
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Rare association of spondylo costal dysostosis with split cord malformations type II: A case report and a brief review of literature. | Spondylo costal dysostosis (SCD) is a genetic skeletal disorder characterized by a variety of costo-vertebral malformations. SCD with type I split cord malformation (SCM) have been reported in the literature. We report an unusual association of SCD with type II SCM. Imaging studies revealed multiple vertebral segmentat... | 25,250,070 | [
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Fatal intratumoral hemorrhage in tectal plate glioblastoma multiforme following ventriculoperitoneal shunt. | Ventriculo-peritoneal (V-P) shunting is an accepted procedure before a direct approach to large tumors producing obstructive hydrocephalus. However, it has been associated with some complications. Intratumoral hemorrhage is an uncommon but fatal complication of V-P shunt insertion. The exact mechanism of this complicat... | 25,250,086 | [
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Evaluation of hemodynamic properties of cerebral venous drainage in patients with multiple sclerosis: a case-control study. | The purpose of this study was to compare patients with multiple sclerosis and healthy control subjects as regards hemodynamics of cerebral venous drainage. Between December 2012 and May 2013, 44 consecutive patients with multiple sclerosis and 44 age- and sex-matched healthy subjects underwent the B-mode, color Doppler... | 25,250,100 | [
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Hedgehog signalling pathway: carcinogenesis and targeted therapy. | Hedgehog signalling pathway has not only a critical role in cell proliferation,differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. Recent research has increased our understanding of this pathway and its relation to other signal... | 25,250,108 | [
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Assessment of Genotoxicity Among Rubber Industry Workers Occupationally Exposed to Toxic Agents Using Micronucleus Assay. | Occupational and environmental exposures mostly represent complexmixture of genotoxic agents, however there is a wide variation in the specificity of biomarkers. Exploration of correlations among biomarkers contributes to the further progress of molecular cancer epidemiology and to the selection of the optimal biomarke... | 25,250,114 | [
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Virotherapy in cancer. | New cancer therapies with novel mechanisms and functions are needed to treatpatients with different cancers. Virotherapy is a good scenario for such treatment. The advantages of virotherapy include the potential lack of cross resistance with standard therapies and the ability to cause tumor destruction by numerous mech... | 25,250,118 | [
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The Estimation of Survival Function for Colon Cancer Data in Tehran Using Non-parametric Bayesian Model. | Colon cancer is the third cause of cancer deaths. Although colon cancer survival time has increased in recent years, the mortality rate is still high. The Cox model is the most common regression model often used in medical research in survival analysis, but most of the time the effect of at least one of the independent... | 25,250,124 | [
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Translation Elongation Rate Measurement of Epstein-Barr Virus Strain GD1. | Epstein-Barr Virus (EBV) has a great co relationship with human malignancies such as gastric carcinoma. Synonymous codon investigations in viruses could help designing vaccine, to generate immunity. Codon Adaptation Index (CAI) has measured translation elongation rate, among the highly expressed genes. The aim of this ... | 25,250,137 | [
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Epidemiological characteristics of head and neck cancers in southeast of iran. | The aim of this study was to investigate the epidemiological aspects of malignant tumors of head and neck in southeast of Iran, with a view toward analyzing the age, gender and site distribution and histological types. All cases with malignant tumor of the head and neck region from 1999 to 2009 were retrieved from the ... | 25,250,154 | [
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Cluster and Principal Component Analysis of Human Glioblastoma Multiforme (GBM) Tumor Proteome. | Glioblastoma Multiforme (GBM) or grade IV astrocytoma is the most common and lethal adult malignant brain tumor. Several of the molecular alterations detected in gliomas may have diagnostic and/or prognostic implications. Proteomics has been widely applied in various areas of science, ranging from the deciphering of mo... | 25,250,155 | [
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Hepatitis-C Infection Incidence Among the non-Hodgkin's B-cell Lymphoma Patients in the Northeast of Iran. | Various infectious agents like Ebstein Barr Virus (EBV), HTLV-1 and Helicobacter pylori have known as etiologic factors in different sub-types of lymphoma. Although Hepatitis C virus (HCV) has not only been important for its hepatotropism and hepatitis development, but also in recent years its association with some for... | 25,250,166 | [
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Component resolved diagnosis: when should it be used? | The knowledge on molecular allergy diagnosis is continuously evolving. It is now time for the clinician to integrate this knowledge and use it when needed to improve the accuracy of diagnosis and thus provide more precise therapeutic and avoidance measures. This review does not intend to comprehensively analyze all the... | 25,250,172 | [
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Arterial Tortuosity Syndrome: An Approach through Imaging Perspective. | This pictorial illustration demonstrates various aspects of arterial tortuosity syndrome (ATS) obtained predominantly from a multiple detector computed tomography (MDCT) examination of a patient. In addition, a comprehensive review of typical multi-modality imaging observations in patients with ATS is presented along w... | 25,250,193 | [
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Comparative performance of PET tracers in biochemical recurrence of prostate cancer: a critical analysis of literature. | Positron emission tomography (PET) with a number of tracers targeted to particular biological features of cancer has been explored for the imaging evaluation of patients with biochemical recurrence of prostate cancer after curative primary treatment. However, these reports are often heterogeneous in study design, patie... | 25,250,207 | [
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Modelling foraging movements of diving predators: a theoretical study exploring the effect of heterogeneous landscapes on foraging efficiency. | Foraging in the marine environment presents particular challenges for air-breathing predators. Information about prey capture rates, the strategies that diving predators use to maximise prey encounter rates and foraging success are still largely unknown and difficult to observe. As well, with the growing awareness of p... | 25,250,211 | [
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The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome. | The oral microbiome is composed of a multitude of different species of bacteria, each capable of occupying one or more of the many different niches found within the human oral cavity. This community exhibits many types of complex interactions which enable it to colonize and rapidly respond to changes in the environment... | 25,250,243 | [
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Habitual dislocation of the hip: a rare case report. | Habitual dislocation of the hip (HDH) in children is a rare entity and can be a causative factor for popping or snapping hip which is a common problem in children with good prognosis. We report a case of HDH in a 9 year old girl who was suffering from frequent snapping hip at night, its course and treatment process. | 25,250,256 | [
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Double-balloon Enteroscopy: The results of a new experience in Iran. | Approach to the small intestine has been difficult even with newer methods. Double-balloon enteroscopy (DBE) has been created for diagnostic and therapeutic interventions in diseases of the small intestine. Small intestinal diseases have different etiologies in each country. The DBE has been introduced in recent years ... | 25,250,264 | [
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Effect of nebulized budesonide in preventing postextubation complications in critically patients: A prospective, randomized, double-blind, placebo-controlled study. | The efficacy of steroid administration in the prevention of postextubation complications in critical care remains controversial. The purpose of this study was to determine whether administration of nebulized budesonide in critically ill patients reduces the occurrence of postextubation airway complications. This was a ... | 25,250,296 | [
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Ergovaline stability in tall fescue based on sample handling and storage methods. | Ergovaline is an ergot alkaloid produced by the endophyte Neotyphodium coenophialum (Morgan-Jones and Gams) found in tall fescue [Schedonorus arundinacea (Schreb.) Dumort.] and blamed for a multitude of livestock disorders. Ergovaline is known to be unstable and affected by many variables. The objective of this study w... | 25,250,308 | [
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Anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others. | Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in ... | 25,250,322 | [
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Are applied growth factors able to mimic the positive effects of mesenchymal stem cells on the regeneration of meniscus in the avascular zone? | Meniscal lesions in the avascular zone are still a problem in traumatology. Tissue Engineering approaches with mesenchymal stem cells (MSCs) showed successful regeneration of meniscal defects in the avascular zone. However, in daily clinical practice, a single stage regenerative treatment would be preferable for menisc... | 25,250,325 | [
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Clinical nonlinear laser imaging of human skin: a review. | Nonlinear optical microscopy has the potential of being used in vivo as a noninvasive imaging modality for both epidermal and dermal imaging. This paper reviews the capabilities of nonlinear microscopy as a noninvasive high-resolution tool for clinical skin inspection. In particular, we show that two-photon fluorescenc... | 25,250,337 | [
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Information-seeking behavior of cardiovascular disease patients in Isfahan University of Medical Sciences hospitals. | Patients, as one of the most prominent groups requiring health-based information, encounter numerous problems in order to obtain these pieces of information and apply them. The aim of this study was to determine the information-seeking behavior of cardiovascular patients who were hospitalized in Isfahan University of M... | 25,250,349 | [
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The effects of applying information technology on job empowerment dimensions. | Information Technology (IT) is known as a valuable tool for information dissemination. Today, information communication technology can be used as a powerful tool to improve employees' quality and efficiency. The increasing development of technology-based tools and their adaptation speed with human requirements has led ... | 25,250,350 | [
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Comparison on information-seeking behavior of postgraduated students in Isfahan University of Medical Sciences and University of Isfahan in writing dissertation based on Kuhlthau model of information search process. | Information-seeking behaviors have been one of the main focuses of researchers in order to identify and solve the problems users face in information recovery. The aim of this research is Comparative on Information-Seeking Behavior of the Postgraduate Students in Isfahan University of Medical Sciences and Isfahan Univer... | 25,250,354 | [
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The effective factors on library anxiety of students in Isfahan University of Medical Sciences and Shiraz University of Medical Sciences. | The efficient use of libraries can be an important factor in determining the educational quality of Universities. Therefore, investigation and identification of factors affecting library anxiety becomes increasingly necessary. The purpose of this research is to determine the factors effecting library anxiety of student... | 25,250,358 | [
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A study on scientific collaboration and co-authorship patterns in library and information science studies in Iran between 2005 and 2009. | Scientific collaboration is among the most important subjects in scientometrics, and many studies have investigated this concept to this day. The goal of the current study is investigation of scientific collaboration and co-authorship patterns of researchers in the field of library and information science in Iran betwe... | 25,250,365 | [
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Evaluation of growth and development pattern in normal, low and very low birth weight neonates at 18 months of age. | Growth and development monitoring could lead to general judgment about children's health. With advances in NICUs establishment, the survival rate of very low birth weight (VLBW) neonates has increased in many countries including Iran. Because of the lack of studies about growth and development pattern of low birth weig... | 25,250,368 | [
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A multianalyzer machine learning model for marine heterogeneous data schema mapping. | The main challenges that marine heterogeneous data integration faces are the problem of accurate schema mapping between heterogeneous data sources. In order to improve the schema mapping efficiency and get more accurate learning results, this paper proposes a heterogeneous data schema mapping method basing on multianal... | 25,250,372 | [
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A method of extracting ontology module using concept relations for sharing knowledge in mobile cloud computing environment. | In mobile cloud computing environment, the cooperation of distributed computing objects is one of the most important requirements for providing successful cloud services. To satisfy this requirement, all the members, who are employed in the cooperation group, need to share the knowledge for mutual understanding. Even i... | 25,250,374 | [
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Research on the trajectory model for ZY-3. | The new generation Chinese high-resolution three-line stereo-mapping satellite Ziyuan 3 (ZY-3) is equipped with three sensors (nadir, backward, and forward views). Its objective is to manufacture the 1 : 50000 topographic map and revise and update the 1 : 25000 topographic map. For the push-broom satellite, the interpo... | 25,250,378 | [
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An enhanced drought-tolerant method using SA-loaded PAMPS polymer materials applied on tobacco pelleted seeds. | Drought is one of the most important stress factors limiting the seed industry and crop production. Present study was undertaken to create novel drought-resistant pelleted seeds using the combined materials with superabsorbent polymer, poly(2-acrylamide-2-methyl propane sulfonic acid) (PAMPS) hydrogel, and drought resi... | 25,250,387 | [
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A MD simulation and analysis for aggregation behaviors of nanoscale zero-valent iron particles in water via MS. | With the development of nanotechnology, more nanomaterials will enter into water environment system. Studying the existing form of nanomaterials in water environment will help people benefit from the correct use of them and to reduce the harm to human caused by them for some nanomaterials can bring polluting effect. Ag... | 25,250,388 | [
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Simulating spatiotemporal dynamics of sichuan grassland net primary productivity using the CASA model and in situ observations. | Net primary productivity (NPP) is an important indicator for grassland resource management and sustainable development. In this paper, the NPP of Sichuan grasslands was estimated by the Carnegie-Ames-Stanford Approach (CASA) model. The results were validated with in situ data. The overall precision reached 70%; alpine ... | 25,250,396 | [
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Use of the Measure of Processes of Care (MPOC-20) to evaluate health service delivery for children with cerebral palsy and their families in Jordan: validation of Arabic-translated version (AR-MPOC-20). | Family-centred service (FCS) is widely accepted now as best practice in paediatric rehabilitation. The Measure of Processes of Care-20 items set (MPOC-20) is a valid and reliable self-report measure of parents' perceptions of the extent to which health services are family-centred. Arabic-translated and validated versio... | 25,250,400 | [
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Two genera Foersteria Szépligeti, 1896 and Polydegmon Foerster, 1862 (Hymenoptera, Braconidae, Brachistinae) from China, with description of a new species. | The genera Foersteria Szépligeti, 1896 and Polydegmon Foerster, 1862 (Hymenoptera, Braconidae, Brachistinae) are recorded for the first time from China. A new species, Foersteria xinjiangensis Yan & Chen, sp. nov., is described and illustrated. A key to the Palaearctic species of Foersteria is given. In addition, P... | 25,250,445 | [
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Heterospilus Haliday, 1836 (Hymenoptera: Braconidae, Doryctinae) from China with a key to species. | The Chinese species of the genus Heterospilus Haliday, 1836 from the Parasitic Hymenoptera Collection of Zhejiang University were studied and thirty-four species are recognized, including 12 previously described species. Eighteen new species of this genus are described and illustrated: Heterospilus (Heterospilus) alter... | 25,250,449 | [
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New Uropodine mites from Tanzania (Acari: Mesostigmata). | Three new species and one new genus of Uropodina from Tanzania are described and illustrated. They include the second species of the genus Bloszykiella Kontschán, 2010, Bloszykiella grebennikovi sp. nov., and the resurrection and re-definition of the genus Spinosissuropoda Hirschmann, 1979, with description of a new sp... | 25,250,451 | [
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Redescription of Ceratothoa carinata (Bianconi, 1869) and Ceratothoa oxyrrhynchaena Koelbel, 1878 (Crustacea: Isopoda: Cymothoidae), buccal-attaching fish parasites new to Australia. | Ceratothoa carinata (Bianconi, 1869) and Ceratothoa oxyrrhynchaena Koelbel, 1878 are recorded for the first time from Australia and redescribed. Ceratothoa curvicauda Nunomura, 2006 is synonymised with Ceratothoa carinata. Brief accounts are given on the distribution and hosts of these species. | 25,250,460 | [
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Egg parasitoids (Hymenoptera: Mymaridae and Trichogrammatidae) of the gall-making leafhopper Scenergates viridis (Hemiptera: Cicadellidae) from Uzbekistan, with taxonomic notes on the Palaearctic species of Aphelinoidea. | A new species of the Aphelinoidea Girault (Hymenoptera: Trichogrammatidae), A. (Aphelinoidea) sariq Triapitsyn & Rakitov sp. n., is described from Uzbekistan. Both sexes were reared from eggs of the only known truly gall-making leafhopper, Scenergates viridis (Vilbaste), laid inside its galls on camelthorn, Alhagi ... | 25,250,467 | [
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Schistura paucireticulata, a new loach from Tuirial River, Mizoram, India (Teleostei: Nemacheilidae). | Schistura paucireticulata, new species, is described from the Tuirial River in Mizoram, India. It is distinguished from its congeners by a combination of characters: 8-9 brown bars on the body, bars in front of the dorsal fin divided into 2-3 small bars forming a reticulations; basicaudal bar black, dissociated; dorsal... | 25,250,471 | [
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mRNA levels of kisspeptins, kisspeptin receptors, and GnRH1 in the brain of chub mackerel during puberty. | Kisspeptin (Kiss) and its cognate receptor (Kiss1R), implicated in the neuroendocrine control of GnRH secretion in mammals, have been proposed to be the key factors in regulating puberty. However, the mechanisms underlying the initiation of puberty in fish are poorly understood. The chub mackerel Scomber japonicus expr... | 25,250,485 | [
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Effects of cucurbitacin e, a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics and pharmacodynamics of warfarin in rats. | This study firstly investigated the effects of cucurbitacin E (CuE), a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics (PK) and pharmacodynamics (PD) of warfarin, a model CYP2C probe substrate, in the rat. In PK studies, the concentration of warfarin in blood samples was determined by HPLC-D... | 25,250,504 | [
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Undervalued criteria in the evaluation of multimodal trials for upper GI cancers. | Global economies and their health systems face a huge challenge from cancer: 1 in 3 women and 1 in 2 men will develop cancer in their lifetime. In the less developed countries, the volume of cancer patients will overwhelm the existing healthcare systems. Even in developed regions, patients with upper gastrointestinal (... | 25,250,506 | [
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An integrative review of ethnic and cultural variation in socialization and children's self-regulation. | To examine the evidence for cross-cultural variation in socialization and children's normative self-regulation, based on a contextual-developmental perspective. Nurses and healthcare workers in multi-cultural societies must understand diversity in socializing influences (including parenting) and in children's behaviour... | 25,250,509 | [
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Habitat structure and the evolution of diffusible siderophores in bacteria. | Bacteria typically rely on secreted metabolites, potentially shareable at the community level, to scavenge resources from the environment. The evolution of diffusible, shareable metabolites is, however, difficult to explain because molecules can get lost, or be exploited by cheating mutants. A key question is whether n... | 25,250,530 | [
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Dioxygen reactivity with a ferrocene-Lewis acid pairing: reduction to a boron peroxide in the presence of tris(pentafluorophenyl)borane. | Ferrocenes, which are typically air-stable outer-sphere single-electron transfer reagents, were found to react with dioxygen in the presence of B(C6 F5 )3 , a Lewis acid unreactive to O2 , to generate bis(borane) peroxide. Although several Group 13 peroxides have been reported, boron-supported peroxides are rare, with ... | 25,250,531 | [
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Metamorphosis in solitary ascidians. | Embryonic and postembryonic development in ascidians have been studied for over a century, but it is only in the last 10 years that the complex molecular network involved in coordinating postlarval development and metamorphosis has started to emerge. In most ascidians, the transition from the larval to the sessile juve... | 25,250,532 | [
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Double input capacitively coupled contactless conductivity detector with phase shift. | A double input capacitively coupled contactless conductivity detector (DIC(4)D) device which gets higher sensitivity has been described in this paper. The detector consists of two input electrodes and one output electrode. When two alternating current (AC) voltages with the same amplitude and different phases are impos... | 25,250,534 | [
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Taxonomic status, phylogenetic affinities and genetic diversity of a presumed extinct genus, Paraisometrum W.T. Wang (gesneriaceae) from the karst regions of Southwest China. | The karst regions in South China have an abundance of endemic plants that face high extinction risks. The Chinese Gesneriaceae endemic Paraisometrum mileense ( = Oreocharis mileensis), was presumed extinct for 100 years. After its re-discovery, the species has become one of five key plants selected by the Chinese fores... | 25,250,568 | [
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Cytotoxicity of polyaniline nanomaterial on rat celiac macrophages in vitro. | Polyaniline nanomaterial (nPANI) is getting popular in many industrial fields due to its conductivity and stability. The fate and effect of nPANI in the environment is of paramount importance towards its technological applications. In this work, the cytotoxicity of nPANI, which was prepared by rapid surface polymerizat... | 25,250,578 | [
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Neonatal ascites in autosomal recessive polycystic kidney disease (ARPKD). | Neonatal ascites is a rare entity, which is usually biliary, urinary, or chylous. Congenital hepatic fibrosis as part of the manifestations of autosomal recessive polycystic kidney disease (ARPKD) is usually a histological adjunct to the diagnosis of this mainly clinically renal entity in the neonatal period. Case-diag... | 25,250,579 | [
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Impact of epinephrine and norepinephrine on two dynamic indices in a porcine hemorrhagic shock model. | Pulse pressure variations (PPVs) and stroke volume variations (SVVs) are dynamic indices for predicting fluid responsiveness in intensive care unit patients. These hemodynamic markers underscore Frank-Starling law by which volume expansion increases cardiac output (CO). The aim of the present study was to evaluate the ... | 25,250,595 | [
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Plasmatic isoforms of cytokeratin 18 and RAGE after severe trauma: a longitudinal cohort study. | Life-threatening traumatic injuries lead to a complex inflammation-driven pathophysiology. Receptor of advanced glycation end product (RAGE) is a multiligand receptor of several endogenous alarmins, while cytokeratin 18 is a structural component of the filament of epithelial cells. Both proteins can be frequently found... | 25,250,597 | [
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Using critical administration thresholds to predict abbreviated laparotomy. | Early identification of trauma patients requiring abbreviated laparotomy (AL) is key to prevent prolonged operative times with associated hypothermia and acidosis. The critical administration threshold (CAT) is a novel method to define large-volume transfusion, accounting for rate and volume simultaneously. CAT may als... | 25,250,600 | [
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Structural melting of an amino acid dimer upon intersystem crossing. | We present a spectroscopic investigation of the excited-state dynamics of the phenylalanine (Phe)/serine (Ser) protonated dimer in the gas phase. Using an ultraviolet (UV) laser pulse, we promote individual isomers to the S1 state and probe their fate with an infrared (IR) pulse. We find that the S1 state has a lifetim... | 25,250,642 | [
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0.214862,
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An imperative need to change organ donation and transplant curriculum results of a nationwide United kingdom junior doctor survey. | Awareness among the medical students and junior doctors about organ donation and transplantation (ODT) may play an important role in increasing organ donor pool. This study surveys the knowledge, perceptions, and attitudes of ODT among the U.K. junior doctors and attempts to identify their educational needs. To our kno... | 25,250,646 | [
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Effect of N-acetylcysteine pretreatment of deceased organ donors on renal allograft function: a randomized controlled trial. | Antioxidant donor pretreatment is one of the pharmacologic strategy proposed to prevent renal ischemia-reperfusion injuries and delayed graft function (DGF). The aim of the study was to investigate whether a donor pretreatment with N-acetylcysteine (NAC) reduces the incidence of DGF in adult human kidney transplant rec... | 25,250,647 | [
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Outcomes of liver transplantation alone after listing for simultaneous kidney: comparison to simultaneous liver kidney transplantation. | Data on patient and liver graft survival comparing liver transplantation alone after listing for kidney with simultaneous liver kidney (SLK) transplantation are scanty. United Network Organ Sharing network database (1994-2011) queried for liver transplantation alone after being listed for kidney and SLK transplants. Of... | 25,250,648 | [
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Comparative assessment of genetic and morphological variation at an extensive hybrid zone between two wild cats in southern Brazil. | Increased attention towards the Neotropical cats Leopardus guttulus and L. geoffroyi was prompted after genetic studies identified the occurrence of extensive hybridization between them at their geographic contact zone in southern Brazil. This is a region where two biomes intersect, each of which is associated with one... | 25,250,657 | [
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Molecular phylogenetics and systematics of the bivalve family Ostreidae based on rRNA sequence-structure models and multilocus species tree. | The bivalve family Ostreidae has a worldwide distribution and includes species of high economic importance. Phylogenetics and systematic of oysters based on morphology have proved difficult because of their high phenotypic plasticity. In this study we explore the phylogenetic information of the DNA sequence and seconda... | 25,250,663 | [
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International variation in performance by clinical discipline and task on the United States medical licensing examination step 2 clinical knowledge component. | To investigate country-to-country variation in performance across clinical science disciplines and tasks for examinees taking the Step 2 Clinical Knowledge (CK) component of the United States Medical Licensing Examination. In 2012 the authors analyzed demographic characteristics, total scores, and percent-correct clini... | 25,250,743 | [
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Integrating competencies: exploring complex problem solving through case formulation in developmental pediatrics. | To understand how experienced clinicians formulate cases and to use this understanding to explore the broader processes involved in how clinicians solve complex problems in their daily work. Case formulation is a process that allows clinicians to provide a tentative explanation for why a patient with a certain conditio... | 25,250,750 | [
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Distress among matriculating medical students relative to the general population. | Many medical students experience distress during medical school. If matriculating medical students (MMSs) begin training with similar or better mental health than age-similar controls, this would support existing concerns about the negative impact of training on student well-being. The authors compared mental health in... | 25,250,752 | [
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0.1237448,
0.3297834,
0.2571285,
0.05147328,
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0.2970465,
-0.07991621,... |
More consensus than idiosyncrasy: Categorizing social judgments to examine variability in Mini-CEX ratings. | Social judgment research suggests that rater unreliability in performance assessments arises from raters' differing inferences about the performer and the underlying reasons for the performance observed. These varying social judgments are not entirely idiosyncratic but, rather, tend to partition into a finite number of... | 25,250,753 | [
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Regional scale prioritisation for key ecosystem services, renewable energy production and urban development. | Although the importance of addressing ecosystem service benefits in regional land use planning and decision-making is evident, substantial practical challenges remain. In particular, methods to identify priority areas for the provision of key ecosystem services and other environmental services (benefits from the enviro... | 25,250,775 | [
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Communication intervention in Rett syndrome: a survey of speech language pathologists in Swedish health services. | To investigate communication intervention that speech language pathologists (SLPs) provide to people with Rett syndrome. A web-based survey targeting all Swedish SLPs working with people currently receiving support from habilitation services. The SLPs reportedly followed recommended practice in the following aspects: (... | 25,250,808 | [
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Ultrafine particles from electric appliances and cooking pans: experiments suggesting desorption/nucleation of sorbed organics as the primary source. | Ultrafine particles are observed when metal surfaces, such as heating elements in electric appliances, or even empty cooking pans, are heated. The source of the particles has not been identified. We present evidence that particles >10 nm are not emitted directly from the heating elements or the metal surfaces. Using... | 25,250,820 | [
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0.1463417,
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HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4: inference for neuroAIDS. | The objective of this study is to verify whether HIV activates two endogenous retroviruses of the human endogenous retrovirus (HERV)-W family, multiple sclerosis-associated retrovirus (MSRV) and Syncytin-1, whose neuropathogenic and immunopathogenic properties could contribute to HIV-related neurodegeneration. Peripher... | 25,250,834 | [
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0.1936868,
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Longevity and cost of implantable intrathecal drug delivery systems for chronic pain management: a retrospective analysis of 365 patients. | Intrathecal drug delivery systems represent an important component of interventional strategies for refractory chronic pain syndromes. Continuous intrathecal administration of opioids results in higher subarachnoid drug concentrations, improved pain scores, and less frequent side effects when compared with systemic opi... | 25,250,852 | [
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0.02479289,
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Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933. | Aberrant Notch activation confers a proliferative advantage to many human tumors, including melanoma. This phase 2 trial assessed the antitumor activity of RO4929097, a gamma-secretase inhibitor of Notch signaling, with respect to the progression-free and overall survival of patients with advanced melanoma. Chemotherap... | 25,250,858 | [
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0.336226,
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A comparative study of transulnar and transradial artery access for percutaneous coronary intervention in patients with acute coronary syndrome. | Transradial access has become commonly used for elective evaluation of patients with coronary artery disease, but it has some disadvantages and has had limited use in the acute coronary syndrome (ACS). Because the diameter of the ulnar artery is usually larger than that of the radial artery, we hypothesized that the ul... | 25,250,862 | [
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0.148997,
0.2672231,
0.0704374... |
Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario. | The identification of cell membrane-bound molecules with a relevant role in cancer cell survival prompted the development of moAbs to block the related pathways. In the last few years, the number of approved moAbs for cancer treatment has constantly increased. Many of these drugs significantly improved the survival out... | 25,250,872 | [
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0.1648632,
0.341814,
0.2684363,
-0.33396... |
Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus. | Fungi-bacteria interactions can impact the course of fungal infection and biotechnological use. The mucoralean fungus Rhizopus microsporus, traditionally used in food fermentations (tempe and sufu), is frequently accompanied by Burkholderia gladioli pv. cocovenenans. When producing tempe bongkrek, the bacterial contami... | 25,250,879 | [
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0.3043843,
0.03525864,
0.3837269,
0.4811946,
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-... |
Morphological variation of the Scorpionfly Panorpa obtusa Cheng (Mecoptera: Panorpidae) with a new synonym. | The overabundance of synonyms is an unavoidable by-product of taxonomic practice in insects. How to reduce or even eliminate synonymy has long been a great challenge for insect taxonomists. The scorpionflies Panorpa obtusa Cheng, 1949 and Panorpa leei Cheng, 1949 (Insecta: Mecoptera: Panorpidae) were originally describ... | 25,250,880 | [
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Orienting the heterocyclic periphery: a structural model for chloroquine's antimalarial activity. | The antimalarial drug chloroquine binds to gallium proto-porphyrin-IX in methanol and in the solid state and represents a unique drug-heme model. | 25,250,883 | [
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0.07296774,
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Chlorella protects against hydrogen peroxide-induced pancreatic β-cell damage. | Oxidative stress has been implicated in the etiology of pancreatic β-cell dysfunction and diabetes. Studies have shown that chlorella could be important in health promotion or disease prevention through its antioxidant capacity. However, whether chlorella has a cytoprotective effect in pancreatic β-cells remains to be ... | 25,250,885 | [
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0.009755654,
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0.3350771,
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Outcomes in biliary malignancy. | The biliary malignancies that are reviewed here are gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (IHC), and perihilar cholangiocarcinoma (PHC). The focus is on outcomes after potentially curative resection of biliary malignancies. Key outcomes are postoperative mortality, median and 5-year overall survival... | 25,250,887 | [
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0.5683874,
0.3319163,
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0.1834873,
0.5262799,
0.09541397,
0.... |
Accuracy and completeness of drug information in Wikipedia: a comparison with standard textbooks of pharmacology. | The online resource Wikipedia is increasingly used by students for knowledge acquisition and learning. However, the lack of a formal editorial review and the heterogeneous expertise of contributors often results in skepticism by educators whether Wikipedia should be recommended to students as an information source. In ... | 25,250,889 | [
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Pharmacopeial HPLC identification methods are not sufficient to detect adulterations in commercial bilberry (Vaccinium myrtillus) extracts. Anthocyanin profile provides additional clues. | Current pharmacopeias provide HPLC anthocyanin profiles to identify commercial bilberry extracts. However, the pharmacopeial identification protocols may not be sufficient enough to distinguish genuine bilberry extracts from adulterated material. This is primarily due to the non-inclusion of literature-reported anthocy... | 25,250,894 | [
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0.1940362,
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Relationship between bent long bones, bent scapulae, and wavy ribs: malformations or variations? | Shortened and bent long bones and bent scapulae are sometimes reported in fetuses with wavy ribs (Carney and Kimmel, ). Wavy ribs are typically seen in the presence of maternal and developmental toxicity, are transient and reversible postnatally, and are considered to be variations rather than malformations. We further... | 25,250,905 | [
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Biochemical characterization of a carboxylesterase from the archaeon Pyrobaculum sp. 1860 and a rational explanation of its substrate specificity and thermostability. | In this work, genome mining was used to identify esterase/lipase genes in the archaeon Pyrobaculum sp. 1860. A gene was cloned and functionally expressed in Escherichia coli as His-tagged protein. The recombinant enzyme (rP186_1588) was verified by western blotting and peptide mass fingerprinting. Biochemical character... | 25,250,909 | [
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0.494993,
0.05243744,
0.1393389,
-0.1431584,
0.14008... |
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