title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The effect of perceptual grouping on haptic numerosity perception. | We used a haptic enumeration task to investigate whether enumeration can be facilitated by perceptual grouping in the haptic modality. Eight participants were asked to count tangible dots as quickly and accurately as possible, while moving their finger pad over a tactile display. In Experiment 1, we manipulated the num... | 25,248,621 | [
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Ensemble theory for slightly deformable granular matter. | Given a granular system of slightly deformable particles, it is possible to obtain different static and jammed packings subjected to the same macroscopic constraints. These microstates can be compared in a mathematical space defined by the components of the force-moment tensor (i.e. the product of the equivalent stress... | 25,248,624 | [
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Symmetric curvature descriptors for label-free analysis of DNA. | High-resolution microscopy techniques such as electron microscopy, scanning tunnelling microscopy and atomic force microscopy represent well-established, powerful tools for the structural characterization of adsorbed DNA molecules at the nanoscale. Notably, the analysis of DNA contours allows mapping intrinsic curvatur... | 25,248,631 | [
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Glycoprotein fucosylation is increased in seminal plasma of subfertile men. | Fucose, the monosaccharide frequent in N- and O-glycans, is a part of Lewis-type antigens that are known to mediate direct sperm binding to the zona pellucida. Such interaction was found to be inhibited in vitroby fucose-containing oligo- and polysaccharides, as well as neoglycoproteins. The objective of this study was... | 25,248,658 | [
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Antimycobacterial activity generated by the amide coupling of (-)-fenchone derived aminoalcohol with cinnamic acids and analogues. | Aminoethyl substituted 2-endo-fenchol prepared from (-)-fenchone was used as scaffold for the synthesis of series of 31 amide structures by N-acylation applying cinnamic acids and analogues. The evaluation of their in vitro activity against Mycobacterium tuberculosis H37Rv showed for some of them promising activity-up ... | 25,248,685 | [
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The effect of liposomal bupivacaine injection during total hip arthroplasty: a controlled cohort study. | Multimodal analgesia following total hip arthroplasty has been shown to improve patient satisfaction, participation with physical therapy, and allow early return to self care. Liposomal bupivacaine is a formulation of local anesthetic which has the potential to provide anesthesia for up to 72 hours following administra... | 25,248,686 | [
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Immobilization of glucose oxidase on graphene and cobalt phthalocyanine composite and its application for the determination of glucose. | We described a simple and facile chemical reduction strategy for the preparation of graphene (GR)-cobalt phthalocyanine (CoPc) composite and explored it for the enzymatic determination of glucose. CoPc is an active mediator and electrocatalysts for the immobilization of GOx and determination of glucose. However, it is ... | 25,248,701 | [
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[Value of modified POSSUM scoring system on predicting operation risk
in elderly NSCLC patients]. | For the assessment of elderly patients can tolerate lung cancer operation, there is no clear standard. To evaluate the clinical validity of POSSUM (Physiological and Operative Severity Score for the Umeration of Mortality and Morbidity) in elderly non-small cell lung cancer (NSCLC) surgery patients, we want to provide ... | 25,248,708 | [
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[Immunohistochemical detections of EGFR mutations in NSCLC]. | In recent years, it has been well known that non-small cell lung cancer (NSCLC) patients with mutations of epidermal growth factor receptor (EGFR) response better to EGFR-tyrosine kinase inhibitor treatment. Although DNA-based assays (e.g. DNA sequencing) are the most frequently used and a relatively reliable method to... | 25,248,714 | [
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Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG. | Owing to the rise in drug resistance in tuberculosis combined with the global spread of its causative pathogen, Mycobacterium tuberculosis (Mtb), innovative anti mycobacterial agents are urgently needed. Recently, we developed a novel primase-pyrophosphatase assay and used it to discover inhibitors of an essential Mtb ... | 25,248,725 | [
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Oligomerization of esculin improves its antibacterial activity and modulates antibiotic resistance. | In this particular study, the antibacterial activity of esculin and oligomer fractions was assessed. MIC values of esculin and its oligomer fractions as well as of some antibiotics against Gram-positive and Gram-negative strains and against Escherichia coli multiresistant variants were determined by the standard broth ... | 25,248,728 | [
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Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. | S-Adenosylhomocysteine hydrolase (SAHH) is an NAD(+)-dependent tetrameric enzyme that catalyzes the breakdown of S-adenosylhomocysteine to adenosine and homocysteine and is important in cell growth and the regulation of gene expression. Loss of SAHH function can result in global inhibition of cellular methyltransferase... | 25,248,746 | [
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Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module. | Caspase-activated DNase (CAD) is a major apoptotic nuclease, responsible for DNA fragmentation and chromatin condensation during apoptosis. CAD is normally activated in apoptosis as a result of caspase cleavage of its inhibitory chaperone ICAD. Other aspects of CAD regulation are poorly understood. In particular, it ha... | 25,248,749 | [
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Potential role of raltegravir-based therapy to induce rapid viral decay in highly viraemic HIV-infected neonates. | We report safety and tolerability of raltegravir (RAL) as a forth HIV agent in two highly viraemic newborns. Raltegravir (6 mg/kg) was given orally twice daily. The other antiretrovirals were assumed according to standard dose for newborns. The first baby was born at week 36. An antiretroviral therapy consisting of zid... | 25,248,795 | [
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Effects of lifestyle intervention on dietary intake, physical activity level, and gestational weight gain in pregnant women with different pre-pregnancy Body Mass Index in a randomized control trial. | The objectives of this study were to assess the efficacy of lifestyle intervention on gestational weight gain in pregnant women with normal and above normal body mass index (BMI) in a randomized controlled trial. A total of 116 pregnant women (<20 weeks of pregnancy) without diabetes were enrolled and 113 pregnant w... | 25,248,797 | [
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Concordance between digital pathology and light microscopy in general surgical pathology: a pilot study of 100 cases. | (1) A pilot study to determine the accuracy of interpretation of whole slide digital images in a broad range of general histopathology cases of graded complexity. (2) To survey the participating histopathologists with regard to acceptability of digital pathology. Glass slides of 100 biopsies and minor resections were d... | 25,248,822 | [
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Obscure gastrointestinal bleeding: diagnostic performance of 64-section multiphase CT enterography and CT angiography compared with capsule endoscopy. | To compare the diagnostic capabilities between capsule endoscopy (CE) and multislice CT (MSCT) enterography in combination with MSCT angiography for assessment of obscure gastrointestinal bleeding (OGIB). A total of 127 patients with OGIB were looked at in this study. 82 patients (aged 42.7 ± 19.1 years; 34 males) were... | 25,248,830 | [
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Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. | Distinct neuronal populations show differential sensitivity to global ischemia, with hippocampal CA1 neurons showing greater vulnerability compared to cortical neurons. The mechanisms that underlie differential vulnerability are unclear, and we hypothesize that intrinsic differences in neuronal cell biology are involve... | 25,248,834 | [
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. | Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the importance of the age-related decline in circulating insulin-like growth factor-1 (IGF-1) levels in cerebrovascular aging,... | 25,248,835 | [
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Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling. | Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activat... | 25,248,858 | [
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Oxidation and reduction processes of platinum nanoparticles observed at the atomic scale by environmental transmission electron microscopy. | Oxidation and reduction of the surfaces of Pt nanoparticles were in situ examined in reactive gases (O2, CO and H2O vapor) by aberration-corrected environmental transmission electron microscopy. Atomic layers of Pt oxides were gradually formed on the surface of Pt nanoparticles at room temperature in O2. The surface Pt... | 25,248,870 | [
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[Development of novel immunotherapy targeting cancer immune evasion]. | Immunotherapy has been developed as an innovative medical intervention against advanced cancer that is refractory to conventional therapies. In recent years, there have been significant advances in our basic knowledge of tumor immunology and ample experience with the clinical application of novel cancer immunotherapies... | 25,248,888 | [
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[A case of successful treatment of hepatocellular carcinoma lumbar metastasis by surgery, chemotherapy, and radiation]. | The incidence of bone metastasis in patients with hepatocellular carcinoma (HCC) has reportedly been increasing. We report a progressive case that presented with a solitary HCC lumbar metastasis. A 44-year-old man was referred to us from a local clinic with a complaint of a painful lump. He was diagnosed with HCC due t... | 25,248,899 | [
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How thermally activated deformation starts in metallic glass. | The studies on dynamics and deformation in glassy materials are particularly challenging because of their strongly disordered atomic structure. Here, by probing the changes in the atomic displacements and stresses at saddle points of the potential energy landscape, we show that thermally activated deformation is trigge... | 25,248,915 | [
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Effects of Training of Affect Recognition on the recognition and visual exploration of emotional faces in schizophrenia. | Schizophrenia patients have impairments in facial affect recognition and display scanpath abnormalities during the visual exploration of faces. These abnormalities are characterized by fewer fixations on salient feature areas and longer fixation durations. The present study investigated whether social-cognitive remedia... | 25,248,938 | [
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A first principles scanning tunneling potentiometry study of an opaque graphene grain boundary in the ballistic transport regime. | We report on a theoretical interpretation of scanning tunneling potentiometry (STP), formulated within the Keldysh non-equilibrium Green's function description of quantum transport. By treating the probe tip as an electron point source/sink, it is shown that this approach provides an intuitive bridge between existing t... | 25,248,965 | [
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Role of primary closure after transoral robotic surgery for tonsillar cancer. | This study was performed to verify the efficacy and feasibility of primary closure for communication defects in the neck after transoral robotic surgery (TORS) for tonsillar cancer, and to verify the necessity of en bloc resection, which can create communication defects during TORS. We applied a new primary closure tec... | 25,248,970 | [
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Perceived Rewards of Nursing Among Christian Nursing Students in Bangalore, India. | Nurses in India face significant challenges and often migrate to practice nursing abroad. Few studies have focused on the rewards of nursing in India. The aim of this study was to illuminate perceived rewards of nursing among Christian student nurses in Bangalore, India. Photovoice, a participatory action methodology w... | 25,248,979 | [
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Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction. | The ˙OH radical is released from 3-trifluoromethyl-quinoxaline 1,4-dioxides upon one-electron reduction by cytochrome P450 oxidoreductase. This process effectively competes with back oxidation of the intermediate radical anion by oxygen and underlies the increased aerobic cytotoxicity of such compounds compared to that... | 25,248,989 | [
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Mineral composition of the sugarcane juice and its influence on the ethanol fermentation. | In the present work, we evaluated the mineral composition of three sugarcane varieties from different areas in northeast Brazil and their influence on the fermentation performance of Saccharomyces cerevisiae. The mineral composition was homogeneous in the different areas investigated. However, large variation coefficie... | 25,248,994 | [
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Expression of ORAII, a plasma membrane resident subunit of the CRAC channel, in rodent and non-rodent species. | We determined the expression of ORAI1 protein in rodent and non-rodent tissues using a monoclonal antibody directed against an extracellular loop of the protein. Previous reports using antibodies directed at the C-terminus of ORAI1 have not detected central nervous system (CNS) expression. Our results demonstrate broad... | 25,249,026 | [
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Four centuries on from Bacon: progress in building health research systems to improve health systems? | In 1627, Francis Bacon's New Atlantis described a utopian society in which an embryonic research system contributed to meeting the needs of the society. In this editorial, we use some of the aspirations described in New Atlantis to provide a context within which to consider recent progress in building health research s... | 25,249,030 | [
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Pharmacotherapy of type 2 diabetes mellitus: an update on drug-drug interactions. | The incidence of type 2 diabetes mellitus is increasing rapidly, as are the associated co-morbidities. Consequently, it has become necessary for a diabetic patient to take multiple medications at the same time to delay progression of the disease. This can put patients at an increased risk of moderate to severe drug int... | 25,249,046 | [
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Innovations in non-communicable diseases management in ASEAN: a case series. | Non-communicable diseases (NCDs) are reaching epidemic proportions worldwide and present an unprecedented challenge to economic and social development globally. In Southeast Asia, the challenges are exacerbated by vastly differing levels of health systems development and funding availability. In addressing the burden o... | 25,249,061 | [
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The role of histamine H1 and H4 receptors in atopic dermatitis: from basic research to clinical study. | Histamine plays important roles in inflammation and nervous irritability in allergic disorders, including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic factors, such as nerve growth factor and semaphorin 3A, in skin keratinocytes via histamine H1 receptor (H1R). Furthermore, H1R antag... | 25,249,063 | [
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Clinical and laboratory characteristics that differentiate hereditary angioedema in 72 patients with angioedema. | Hereditary angioedema (HAE) is a rare but life-threatening condition that results from mutations in C1-inhibitor (C1-INH). Since distinguishing HAE from other causes of angioedema (AE) is a critical problem in emergencies, the objective of the present study was to clarify the differences between HAE and other forms of ... | 25,249,065 | [
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Quality of life assessment after peroral endoscopic myotomy. | Peroral Endoscopic Myotomy (POEM) is a promising treatment option for motor disorders of the esophagus. The purpose of this study was to assess quality of life (QOL) postoperatively. All patients who presented to our institution for surgical treatment of achalasia after 2011 were asked to complete QOL (SF-36), dysphagi... | 25,249,144 | [
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[Investigation of the use of triclosan in patients with indwelling catheters: a randomized, double blind, multicenter, placebo-controlled clinical study]. | This article presents the first randomized, double blind, multicenter, placebo-controlled, non-interventional trial with a medical product after approval by the ethical committee of the medical council of North-Rhine. The study investigated the use of the antimicrobial agent triclosan (Farco-fill® Protect) as a liquid ... | 25,249,158 | [
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Comparative community-level associations of helminth infections and microparasite shedding in wild long-tailed macaques in Bali, Indonesia. | Helminthes have the capacity to modulate host immunity, leading to positive interactions with coinfecting microparasites. This phenomenon has been primarily studied during coinfections with a narrow range of geo-helminthes and intracellular microparasites in human populations or under laboratory conditions. Far less is... | 25,249,163 | [
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Cognitive consequences of overweight and obesity in the ninth decade of life? | the association between late-life obesity and late-life cognitive abilities is poorly understood. We studied the association between body mass index (BMI) and cognitive change in longitudinal population-based study spanning over the ninth decade of life. in total, 475 participants free of dementia at baseline from the ... | 25,249,169 | [
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Equilibrium spin current in graphene with Rashba spin-orbit coupling. | The existence of a background spin current under thermodynamic equilibrium is an interesting phenomenon in the two-dimensional electron gas with Rashba spin-orbit coupling (RSOC). Here we study the equilibrium spin current (ESC) in graphene with RSOC. For an infinite graphene with uniform RSOC, we found that the ESC is... | 25,249,215 | [
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Caecum lipoma: a rare cause of lower gastrointestinal bleeding. | Gastrointestinal bleeding caused by benign tumours of the colon is rare. A 70-year-old woman with a significant medical history of diabetes, hypertension and ischaemic heart disease was presented in consultation with marked anaemia secondary to lower gastrointestinal bleeding with a right colonic tumour found by CT. Th... | 25,249,223 | [
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Systematic review and meta-analysis of effects of foot orthoses on pain and disability in rheumatoid arthritis patients. | This meta-analysis examined the effects of foot orthoses (FO) on pain and disability in rheumatoid arthritis (RA) patients. MEDLINE, Cochrane Controlled Trials Register, EMBASE, SPORT Scielo, and CINAHL were searched through July 2014 for randomized controlled trials (RCTs) examining the effects of orthoses on pain and... | 25,249,238 | [
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Effect of iron oxide loading on magnetoferritin structure in solution as revealed by SAXS and SANS. | Synthetic biological macromolecule of magnetoferritin containing an iron oxide core inside a protein shell (apoferritin) is prepared with different content of iron. Its structure in aqueous solution is analysed by small-angle synchrotron X-ray (SAXS) and neutron (SANS) scattering. The loading factor (LF) defined as the... | 25,249,246 | [
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Description of robotically assisted single-site transabdominal preperitoneal (RASS-TAPP) inguinal hernia repair and presentation of clinical outcomes. | The aim of our study is to report our initial clinical experience with robotically assisted single-site transabdominal preperitoneal (RASS-TAPP) hernia repair, to verify the safety and efficacy of the procedure and to describe the surgical procedure. We retrospectively reviewed all patients undergoing RASS-TAPP at our ... | 25,249,251 | [
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Synthesis and influenza virus inhibitory activities of carbosilane dendrimers peripherally functionalized with hemagglutinin-binding Peptide. | A series of carbosilane dendrimers uniformly functionalized with hemagglutinin (HA) binding peptide (sialic acid-mimic peptide, Ala-Arg-Leu-Pro-Arg) was systematically synthesized, and their anti-influenza virus activity was evaluated. The carbosilane-based peptide dendrimers, unlike sialylated dendrimers, cannot be di... | 25,249,262 | [
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Cyclodextrin-functionalized chromatographic materials tailored for reversible adsorption. | Novel dendronized silica substrates were synthesized. First- and second- generation polyaryl ether dendrons were appended to silica surfaces. Using Cu(I) mediated cycloaddition "click" chemistry, β-cyclodextrin was tethered to the dendronized surfaces and to a nondendronized surface for comparison purposes. This synthe... | 25,249,268 | [
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Modeling the implementation of universal coverage for HIV treatment as prevention and its impact on the HIV epidemic. | The Joint United Nations Programme on HIV/AIDS (UNAIDS) recently updated its global targets for antiretroviral therapy (ART) coverage for HIV-positive persons under which 90 % of HIV-positive people are tested, 90 % of those are on ART, and 90 % of those achieve viral suppression. Treatment policy is moving toward trea... | 25,249,293 | [
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Survival analysis of postoperative nausea and vomiting in patients receiving patient-controlled epidural analgesia. | Postoperative nausea and vomiting as well as postoperative pain are two major concerns when patients undergo surgery and receive anesthetics. Various models and predictive methods have been developed to investigate the risk factors of postoperative nausea and vomiting, and different types of preventive managements have... | 25,249,302 | [
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Effect of milrinone therapy on splanchnic perfusion after heart transplantation. | Milrinone is a selective inhibitor of the cAMP-specific phosphodiesterase III isoenzyme in myocardium and vascular smooth muscle. Milrinone administration following heart transplantation is routine practice. The purpose of this study was to evaluate the influence of milrinone therapy on splanchnic perfusion following h... | 25,249,304 | [
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Surgical removal of intra-abdominal intrauterine devices at one center in a 20-year period. | To review 20 years of experience of the removal of intra-abdominal intrauterine devices (IUDs) and to compare the surgical methods used. In a retrospective study, charts dating from between September 1, 1992, and August 31, 2012, were reviewed. Patients were eligible for inclusion when they had an IUD surgically remove... | 25,249,316 | [
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Benign breast tissue composition in breast cancer patients: association with risk factors, clinical variables, and gene expression. | Breast tissue composition (epithelium, non-fatty stroma, and adipose) changes qualitatively and quantitatively throughout the lifespan, and may mediate relationships between risk factors and breast cancer initiation. We sought to identify relationships between tissue composition, risk factors, tumor characteristics, an... | 25,249,325 | [
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Stone disease in pregnancy: imaging-guided therapy. | Renal colic is the most frequent nonobstetric cause for abdominal pain and subsequent hospitalization during pregnancy. The physio-anatomical changes in the urinary tract and the presence of the fetus may complicate the clinical presentation and management of nephrolithiasis. Ultrasound (US) is the primary radiological... | 25,249,333 | [
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Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice. | Information concerning the cellular localization of cholecystokinin (CCK)-1 receptors has been discrepant and remained scanty at ultrastructural levels. The present immunohistochemical study at light and electron microscopic levels revealed the distinct localization of CCK1 receptors in visceral organs. Immunohistochem... | 25,249,350 | [
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Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers. | Anxiety is common among cancer patients and their family caregivers (FCs) and is associated with poorer outcomes. Recently, associations between inflammation and anxiety were identified. However, the relationship between variations in cytokine genes and anxiety warrants investigation. Therefore, phenotypic and genotypi... | 25,249,351 | [
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Successful catheter ablation of a left anterior accessory pathway from the non-coronary cusp of the aortic valve. | Left anterior accessory pathways are considered to be rare findings. Catheter ablation of accessory pathways in this location remains a challenging target, and few reports about successful ablation of these accessory pathways are available. We describe our experience regarding a case of a manifest left anterior accesso... | 25,249,369 | [
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The potential application of personalized preventive research. | With increases in life expectancy, the focus has shifted to living a healthier, longer life. By concentrating on preventing diseases before occurrence, researchers aim to diminish the increasing gap in medical costs and health inequalities prevalent across many nations. Although we have entered an era of post-genomics,... | 25,249,379 | [
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A functional comparison of conventional knee-ankle-foot orthoses and a microprocessor-controlled leg orthosis system based on biomechanical parameters. | The microprocessor-controlled leg orthosis C-Brace enables patients with paretic or paralysed lower limb muscles to use dampened knee flexion under weight-bearing and speed-adapted control of the swing phase. The objective of the present study was to investigate the new technical functions of the C-Brace orthosis, base... | 25,249,381 | [
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Motor skill learning enhances the expression of activity-regulated cytoskeleton-associated protein in the rat cerebellum. | Motor skill learning is essential for environmental adaptations during everyday life. It has been shown that the cerebellum plays an important role in both the adaptation of eye movements and the motor skill learning. However, the neuronal substrates responsible for consolidation of complex motor skills rather than sim... | 25,249,385 | [
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Syndemic vulnerability, sexual and injection risk behaviors, and HIV continuum of care outcomes in HIV-positive injection drug users. | Limited investigations have been conducted on syndemics and HIV continuum of care outcomes. Using baseline data from a multi-site, randomized controlled study of HIV-positive injection drug users (n = 1,052), we examined whether psychosocial factors co-occurred, and whether these factors were additively associated with... | 25,249,392 | [
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OrthoClust: an orthology-based network framework for clustering data across multiple species. | Increasingly, high-dimensional genomics data are becoming available for many organisms.Here, we develop OrthoClust for simultaneously clustering data across multiple species. OrthoClust is a computational framework that integrates the co-association networks of individual species by utilizing the orthology relationship... | 25,249,401 | [
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Neuroanatomy of Individual Differences in Language in Adult Males with Autism. | One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural language are associated with current neuroanatomy. Groups with and without language delay differ... | 25,249,409 | [
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Lingual traction to facilitate fiber-optic intubation of difficult airways: a single-anesthesiologist randomized trial. | Flexible fiber-optic bronchoscope-guided orotracheal intubation is a valuable technique with demonstrated benefits in the management of difficult airways. Despite its popularity with anesthesia providers, the technique is not fail-safe and airway-related complications secondary to failed intubation attempts remain an i... | 25,249,430 | [
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Classification of subpopulations of cells within human primary brain tumors by single cell gene expression profiling. | Brain tumors are heterogeneous with respect to genetic and histological properties of cells within the tumor tissue. To study subpopulations of cells, we developed a protocol for obtaining viable single cells from freshly isolated human brain tissue for single cell gene expression profiling. We evaluated this technique... | 25,249,434 | [
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Transcriptomic analysis of mouse limb tendon cells during development. | The molecular signals driving tendon development are not fully identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis (Scx) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon ... | 25,249,460 | [
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Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord. | Glia constitute the majority of cells in the mammalian central nervous system and are crucial for neurological function. However, there is an incomplete understanding of the molecular control of glial cell development. We find that the transcription factor Ascl1 (Mash1), which is best known for its role in neurogenesis... | 25,249,462 | [
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The number of locking screws predicts the risk of nonunion and reintervention in periprosthetic total knee arthroplasty fractures treated with a nail. | Periprosthetic knee fractures following total knee arthroplasty are increasing proportionally to the number of primary procedures done. We performed a retrospective review of Rorabeck type II fractures treated with a retrograde nail, trying to find the relationship between failure and the number of distal locking screw... | 25,249,480 | [
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Effects of far-infrared radiation on heart rate variability and central manifestations in healthy subjects: a resting-fMRI study. | The aim of this study was to investigate the autonomic responses and central manifestations by peripheral FIR stimulation. Ten subjects (mean ± SD age 26.2 ± 3.52 years) received FIR stimulation at left median nerve territory for 40 min. Electrocardiograph was continuously recorded and heart rate variability (HRV) were... | 25,249,495 | [
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The current state of stem cell therapeutics: Canadian approaches in the international context. | After ischemic injury, the endogenous repair mechanisms of the human heart are insufficient for meaningful tissue regeneration, so muscle lost is replaced by noncontractile scar tissue. Current treatments for ischemic cardiomyopathy improve quality of life and increase life expectancy, but cannot cure the underlying di... | 25,249,498 | [
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Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. | Studies in both humans and rodents suggest that maternal diabetes leads to a higher risk of the fetus developing impaired glucose tolerance and obesity during adulthood. However, the impact of hyperinsulinemia in the mother on glucose homeostasis in the offspring has not been fully explored. We aimed to determine the c... | 25,249,504 | [
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Blood volumes in cardiac surgery with cardiopulmonary bypass. | Total blood volume (TBV) estimation potentially impacts various aspects of cardiac surgical care, including pharmacological and transfusion interventions, hemodynamic and volume management and perfusion equipment selection. TBV is commonly computed during cardiopulmonary bypass (CPB), using standardized formulae. We hy... | 25,249,518 | [
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Tissue perfusion in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components. | This study evaluates the hemoglobin-oxygen relationship and tissue perfusion during cardiopulmonary bypass (CPB) in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components. We compared perioperative hematocrit (Hct), fetal hemoglobin (HbF), p(50)O(2), pH, pCO(2), serum lac... | 25,249,520 | [
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[Microbial synthesis of deuterium labelled L-phenylalanine with different levels of isotopic enrichment by facultative methylotrophic bacterium Brevibacterium methylicum with RMP assimilation of carbon]. | The preparative microbial synthesis of amino acids labelled with stable isotopes, including deuterium ( 2 H), suitable for biomedical applications by methylotrophic bacteria was studied using L-phenylalanine as example. This amino acid is secreted by Gram-negative aerobic facultative methylotrophic bacteria Brevibacter... | 25,249,528 | [
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An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models. | Mesothelin (MSLN) is an attractive target for antibody-drug conjugate therapy because it is highly expressed in various epithelial cancers, with normal expression limited to nondividing mesothelia. We generated novel antimesothelin antibodies and conjugated an internalizing one (7D9) to the microtubule-disrupting drugs... | 25,249,555 | [
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Nocardioides daecheongensis sp. nov., isolated from soil. | Strain KIS2-16(T) was isolated from a soil sample collected from Daecheong Island of Incheon region, South Korea. KIS2-16(T) was Gram-staining-positive, aerobic, non-spore-forming, non-motile, catalase-positive, oxidase-negative and mesophilic. On the basis of 16S rRNA gene sequence analysis, strain KIS2-16(T) represen... | 25,249,564 | [
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What Do We Really Need? Visions of an Ideal Human-Machine Interface for NOTES Mechatronic Support Systems From the View of Surgeons, Gastroenterologists, and Medical Engineers. | To investigate why natural orifice translumenal endoscopic surgery (NOTES) has not yet become widely accepted and to prove whether the main reason is still the lack of appropriate platforms due to the deficiency of applicable interfaces. To assess expectations of a suitable interface design, we performed a survey on hu... | 25,249,584 | [
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Fluorescence lifetime imaging of the ocular fundus in mice. | Fundus autofluorescence (AF) is characterized not only by its intensity or excitation and emission spectra but also by the lifetimes of the fluorophores. Fluorescence lifetime is influenced by the fluorophore's microenvironment and may provide information about the metabolic tissue state. We report quantitative and qua... | 25,249,601 | [
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The relationship between retinal nerve fiber layer thickness and optic nerve head neuroretinal rim tissue in glaucoma. | The purpose of this study was to determine the relationship between optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) and neuroretinal rim (NRR) in a nonhuman primate experimental glaucoma model, and in a population of clinical patients. For nonhuman primates, normative data were collected... | 25,249,610 | [
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Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase. | Interactions between helicases and the tracking strand of a DNA substrate are well-characterized; however, the role of the displaced strand is a less understood characteristic of DNA unwinding. Dda helicase exhibited greater processivity when unwinding a DNA fork compared to a ss/ds DNA junction substrate. The lag phas... | 25,249,618 | [
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SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression. | Polycomb group (PcG) complexes regulate cellular identity through epigenetic programming of chromatin. Here, we show that SSX2, a germline-specific protein ectopically expressed in melanoma and other types of human cancers, is a chromatin-associated protein that antagonizes BMI1 and EZH2 PcG body formation and derepres... | 25,249,625 | [
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Insyght: navigating amongst abundant homologues, syntenies and gene functional annotations in bacteria, it's that symbol! | High-throughput techniques have considerably increased the potential of comparative genomics whilst simultaneously posing many new challenges. One of those challenges involves efficiently mining the large amount of data produced and exploring the landscape of both conserved and idiosyncratic genomic regions across mult... | 25,249,626 | [
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Relation of exercise capacity with lung volumes before and after 6-minute walk test in subjects with COPD. | There is growing evidence that exercise-induced variation in lung volumes is an important source of ventilatory limitation and is linked to exercise intolerance in COPD. The aim of this study was to compare the correlations of walk distance and lung volumes measured before and after a 6-min walk test (6MWT) in subjects... | 25,249,649 | [
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Liraglutide and the preservation of pancreatic β-cell function in early type 2 diabetes: the LIBRA trial. | Clinical studies evaluating the effects of medications on β-cell function in type 2 diabetes (T2DM) are compromised by an inability to determine the actual baseline degree of β-cell dysfunction independent of the reversible dysfunction induced by hyperglycemia (glucotoxicity). Short-term intensive insulin therapy (IIT)... | 25,249,651 | [
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-0.3351506,
-0.03836853,
-0.003733688,
-0.05241253,
-0.04842067,
0.3806208,
0.0939996... |
Extracardiac Fontan in apicocaval juxtaposition. | Extracardiac total cavopulmonary connection between the inferior vena cava and right pulmonary artery has become the most popular Fontan modification nowadays, yielding good results. However, certain situs anomalies along with systemic venous drainage variations give rise to an issue about the best way for extracardiac... | 25,249,659 | [
-0.260518,
0.09450556,
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0.3097414,
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0.3359383,
0.2365671,
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0.08310013,
0.1455943,
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0.1575544,
0.2975788,
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... |
The effects of dipeptidyl peptidase-4 inhibition on microvascular diabetes complications. | We performed a review of the literature to determine whether the dipeptidyl peptidase-4 inhibitors (DPP4-I) may have the capability to directly and positively influence diabetic microvascular complications. The literature was scanned to identify experimental and clinical evidence that DPP4-I can ameliorate diabetic mic... | 25,249,673 | [
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0.06779516,
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0.02685626,
0.3018005,
0.1066415,
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0.1361428,
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0.0002845164,
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0.1193644,
0.1297308,
0.1623113,
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0.1600875,
-0.2197029,
... |
Functional Genomics and a New Era in Radiation Biology and Oncology. | Ionizing radiation is a ubiquitous stress to which all life is continuously exposed, and thus complex mechanisms have evolved to regulate cellular responses to radiation, including cell cycle arrest, DNA repair, and programmed cell death. Changes in gene expression shape part of the response to radiation, and have hist... | 25,249,699 | [
-0.1426185,
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0.01706306,
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0.1189368,
0.3135681,
0.3090869,
0.08372598,
0.002666259,
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0.1825236,
0.02965808,
0.03713432,
0.1496731,
0.4095181,
0.335019,
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... |
Feature Screening via Distance Correlation Learning. | This paper is concerned with screening features in ultrahigh dimensional data analysis, which has become increasingly important in diverse scientific fields. We develop a sure independence screening procedure based on the distance correlation (DC-SIS, for short). The DC-SIS can be implemented as easily as the sure inde... | 25,249,709 | [
0.1739513,
0.1762949,
0.2030848,
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0.1790658,
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0.3708467,
0.01080474,
0.09479307,
0.116462,
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0.1653769,
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0.2021521,
0.2692423,
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0... |
Prevention of bacterial foodborne disease using nanobiotechnology. | Foodborne disease is an important source of expense, morbidity, and mortality for society. Detection and control constitute significant components of the overall management of foodborne bacterial pathogens, and this review focuses on the use of nanosized biological entities and molecules to achieve these goals. There i... | 25,249,756 | [
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0.01232092,
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0.03322903,
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0.2780435,
0.1128984,
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0.09272185,
-0.1304957,... |
Molecular cloning and mRNA expression of the peptidoglycan recognition protein gene HcPGRP1 and its isoform HcPGRP1a from the freshwater mussel Hyriopsis cumingi. | Peptidoglycan recognition proteins (PGRPs) are innate immune molecules that have been structurally conserved throughout evolution in invertebrates and vertebrates. In this study, peptidoglycan recognition protein HcPGRP1 and its isoform HcPGRP1a were identified in the freshwater mussel Hyriopsis cumingii. The full-leng... | 25,249,773 | [
0.1825361,
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0.1108061,
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0.2272113,
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0.1326142,
0.3684212,
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0.1468769,
0.1457365,
-0.03556865,... |
Genetic variation in cultivated Rheum tanguticum populations. | To examine whether cultivation reduced genetic variation in the important Chinese medicinal plant Rheum tanguticum, the levels and distribution of genetic variation were investigated using ISSR markers. Fifty-eight R. tanguticum individuals from five cultivated populations were studied. Thirteen primers were used and a... | 25,249,777 | [
0.2223084,
0.1815651,
0.1977303,
0.1936794,
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0.3577771,
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0.441903,
0.3951562,
0.2380396,
-0.1937387,
0.0014757... |
Propofol infusion syndrome or not? A case report. | Propofol is commonly used and well tolerated for induction of general anesthesia and is also used as a sedative in the intensive care unit. However, in rare cases, the agent may cause a fatal condition known as propofol infusion syndrome (PRIS). We present a case of PRIS that could have been fatal in a previously healt... | 25,249,811 | [
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0.08611912,
0.1254622,
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0.110428,... |
Peduncular hallucinosis: a case report. | Peduncular hallucinosis is a rare form of visual hallucination often described as vivid, colorful visions of people and animals. The exact pathophysiology is unknown; however, most cases have been described in relation to lesions in the thalamus or midbrain. We present the case of a 59-year-old female with peduncular h... | 25,249,815 | [
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0.3344167,
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0.3330266,
0.5274398,
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0.0662608,
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0.2178942,
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-0.05668677,
0.02643398,
0.1295813,
-0.1605407... |
Temporomandibular condylar alterations in juvenile idiopathic arthritis most common in longitudinally severe disease despite medical treatment. | Juvenile idiopathic arthritis (JIA) is an autoimmune, heterogeneous disease and the temporomandibular joint (TMJ) can be affected, with consequences for mandibular growth and function. The aim of this study was to evaluate the importance of longitudinal medical treatment and the burden of disease activity on the develo... | 25,249,821 | [
-0.1568884,
0.2265035,
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0.1701823,
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0.1291118,
0.3373767,
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0.09410433,
0.6509677,
0.2631575,
0.16632,
0.2922176,
0.0683203,
-0.08176963,
0.15... |
Burn wound healing with injection of adipose-derived stem cells: a mouse model study. | Stem cells have shown promise with regard to the healing process of burn wounds. However, donor sites for these cells are still under investigation. The aim of this study is to review the efficacy of adipose tissue-derived stem cells (ADSCs) in accelerating wound healing of third degree burns in a mouse model. To this ... | 25,249,847 | [
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0.006535429,
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0.290567,
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-0.093... |
Crystal structure of bis-[3-meth-oxy-17β-estra-1,3,5(10)-trien-17-yl] oxalate. | In the title compound, C40H50O6, a symmetrical steroid oxalate diester, the dihedral angle between the CO2 planes of the oxalate linker is 61.5 (5)° and the C-C bond length is 1.513 (6) Å. The steroid B, C and D rings adopt half-chair, chair and envelope conformations, respectively, in both halves of the mol-ecule, whi... | 25,249,855 | [
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0.5012689,
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0.2491224,
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0.1786231,
0.341327,
0.1514977,
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0.053... |
Crystal structures of potassium tri-fluorido-(4-meth-oxy-phen-yl)borate and potassium tri-fluorido(4-fluoro-phen-yl)borate. | The title compounds, K(+)·C7H7BF3O(-), (I), and K(+)·C6H4BF4 (-), (II), are mol-ecular salts containing para-substituted phenyl-tri-fluorido-borate anions. In each compound, the B atom adopts a distorted tetra-hedral BCF3 geometry. Despite their different compositions and space groups, the irregular KF8 coordination po... | 25,249,857 | [
-0.3378339,
0.08543414,
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0.03620943,
0.1011044,
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0.3307509,
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0.382443,
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0.1190252,
0.3071888,
0.2331953,
0.05341512,
... |
Crystal structure of bis-[1-(naphthalen-1-ylmeth-yl)pyridinium] bis-(2,2-di-cyano-ethene-1,1-di-thiol-ato-κ(2) S,S')nickelate(II). | A new ion-pair complex, (C16H14N)2[Ni(C4N2S2)2] or (1-NaMePy)2[Ni(imnt)2], where 1-NaMePy is 1-(4-naphthyl-methyl-ene)pyridinium and imnt is 2,2-di-cyano-ethene-1,1-di-thiol-ate, was obtained by the direct reaction of NiCl2, K2imnt and (1-NaMePy)(+)Br(-) in H2O. The asymmetric unit contains a [1-NaMePy](+) cation and o... | 25,249,870 | [
-0.25297,
0.301089,
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-0.07006779,
-0.1481972,
0.1527588,
-0.5242099,
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0.3538572,
0.04233486,
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0.3466236,
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0.2571728,
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0.1904804,
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0.06518354,
-0.1928268,
... |
Diterbium hepta-nickel: a crystal structure redetermination. | The crystal structure of the title compound, Tb2Ni7, was redetermined from single-crystal X-ray diffraction data. In comparison with previous studies based on powder X-ray diffraction data [Lemaire et al. (1967). C. R. Acad. Sci. Ser. B, 265, 1280-1282; Lemaire & Paccard (1969). Bull. Soc. Fr. Mineral. Cristallogr.... | 25,249,871 | [
-0.08128128,
0.02420164,
-0.03820694,
0.1089673,
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-0.2787,
-0.5227435,
0.1051919,
0.1065997,
0.08378398,
0.1246609,
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0.1842174,
0.1006066,
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0.2816015,
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0.2857601,
0.1708689,
0.2777479,
-0.04484845,
... |
Poly[[tri-μ-aqua-do-deca-aqua-tris-(μ3-1-hy-droxy-ethyl-idene-1,1-di-phospho-nato)tricalcium(II)tripalladium(II)] penta-hydrate]. | The asymmetric unit of the title compound, {[CaPd{CH3OHC(PO3)2}(H2O)5]·5/3H2O} n , consists of one half of the complex [Pd{CH3OHC(PO3)2}](2-) anion (point group symmetry m..), one Ca(2+) cation [site symmetry (.2.)] that is surrounded by three water mol-ecules (one of which is on the same rotation axis) and by three di... | 25,249,877 | [
-0.2801681,
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0.08458546,
0.08550745,
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0.0002488287,
0.08370942,
0.06543503,
-0.08986853,
0.2955148,
0.0677674,
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-0.6802162,
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-0.5971617,
0.2834555,
0.1004236,
0.3450297,
0.2322676,
0.4997906,
-0.1603635... |
Bis(2-amino-4-phenyl-1,3-thia-zol-3-ium) tetra-chlorido-palladate(II). | The title compound, (C9H9N2S)2[PdCl4], consists of two monoprotonated 2-amino-4-phenyl-1,3-thia-zole molecules and one tetra-chlorido-palladate anion. The organic molecules exhibit a dihedral angle between the main rings planes of 31.82 (9)°. In the anion, the Pd(II) atom is located on a crystallographic centre of symm... | 25,249,879 | [
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0.08990244,
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0.08854135,
0.04032632,
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0.02263643,
0.1209157,
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0.2839251,
0.1149632,
0.2679556,
0.3520703,
0.1367611,
-0.1966932,
-... |
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