title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Silencing of STRN4 suppresses the malignant characteristics of cancer cells. | The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor supp... | 25,250,919 | [
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Pharmacoepidemiological assessment of drug interactions with vitamin K antagonists. | We present a database of prescription drugs and international normalized ratio (INR) data and the applied methodology for its use to assess drug-drug interactions with vitamin K antagonists (VKAs). We use the putative interaction between VKAs and tramadol as a case study. We used a self-controlled case series to estima... | 25,250,949 | [
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Biogeography and phylogenetic position of a warm-stenotherm centric diatom, Skeletonema potamos (C.I. Weber) hasle and its long-term dynamics in the River Danube. | Skeletonema potamos is a poorly known freshwater species in the ancestrally and predominantly marine genus Skeletonema. With phylogenetic analysis of two nuclear {partial SSU (18S) and partial LSU (28S) rDNA)} and two chloroplast (rbcL and psbC) genes, we verified its placement within the genus Skeletonema and identifi... | 25,250,953 | [
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Identification of a novel missense mutation in the WFS1 gene as a cause of autosomal dominant nonsyndromic sensorineural hearing loss in all-frequencies. | Hearing loss is the most common sensory disorder affecting 278 million people in the world, and more than 60% of hearing loss patients can be attributed to genetic causes. Although many loci have been linked to hereditary hearing impairment, most of the causative genes have not been identified as yet. The goal of this ... | 25,250,959 | [
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Can culture influence body-specific associations between space and valence? | People implicitly associate positive ideas with their dominant side of space and negative ideas with their non-dominant side. Right-handers tend to associate "good" with "right" and "bad" with "left," but left-handers associate "bad" with "right" and "good" with "left." Whereas right-handers' implicit associations alig... | 25,250,987 | [
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Common questions about outpatient care of premature infants. | Preterm births (deliveries before 37 weeks' gestation) comprise 12% of all U.S. births and are responsible for onethird of all infant deaths. Neonatal medical advances have increased survival, and primary care physicians often care for infants who were in the neonatal intensive care unit after birth. Functions of the p... | 25,250,998 | [
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Ammonium uptake by phytoplankton regulates nitrification in the sunlit ocean. | Nitrification, the microbial oxidation of ammonium to nitrate, is a central part of the nitrogen cycle. In the ocean's surface layer, the process alters the distribution of inorganic nitrogen species available to phytoplankton and produces nitrous oxide. A widely held idea among oceanographers is that nitrification is ... | 25,251,022 | [
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Molecular recognition study on the binding of calcium to calbindin D9k based on 3D reference interaction site model theory. | Ca(2+)-binding proteins are widely distributed throughout cells and play various important roles. Calbindin D9k is a member of the EF-hand Ca(2+)-binding protein family. In this study, we examined the binding of Ca(2+) to calbindin D9k in terms of the free energy of solvation, as obtained by 3D reference interaction si... | 25,251,030 | [
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Improving outcomes for patients with acute myeloid leukemia in first relapse: a single center experience. | The outcome of patients with relapsed acute myeloid leukemia (AML) remains unsatisfactory, with few available effective therapies. Increased understanding of the biology of the disease has led to the identification of novel therapeutic agents, several of which have been evaluated in recently conducted clinical trials. ... | 25,251,041 | [
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Energy Expenditure in Institutionalized Older Adults: Validation of SenseWear Mini. | Objective methods to quantify physical activity (PA) and predict energy expenditure (EE) are needed in the old and old-old. The aim of the present study was to evaluate the validity of EE estimates by the SenseWear Mini (SWMini) compared with indirect calorimetry during daily life activities in institutionalized older ... | 25,251,046 | [
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Strength fitness and body weight status on markers of cardiometabolic health. | Recent evidence suggests that resistance training (RT) may reduce metabolic and cardiovascular disease risk. We investigated whether overweight/class I obese individuals by BMI classification with high strength fitness exhibit cardiovascular/metabolic phenotypes similar to those overweight/obese and untrained or those ... | 25,251,047 | [
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Small heat shock proteins (HSP12, HSP20 and HSP30) play a role in Ustilago maydis pathogenesis. | Small heat shock proteins (HSP) have multiple functions within a cell. These functions primarily include regulation of growth and survival in response to different stresses. However in some cases small HSPs have been shown to play crucial roles in microbial pathogenesis. Ustilago maydis genome also codes for a number o... | 25,251,081 | [
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Finger movement function after ultrasound-guided percutaneous pulley release for trigger finger: effects of postoperative rehabilitation. | To develop and test a postoperative rehabilitation protocol for use by individuals with trigger finger undergoing ultrasound-guided percutaneous pulley release. Nonrandomized controlled trial. Hospital and local community. Individuals suffering from trigger finger with joint contracture (N=21) were recruited and groupe... | 25,251,102 | [
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Studying nursing interventions in acutely ill, cognitively impaired older adults. | Although it increases the risk of poor outcomes and raises the costs of care, cognitive impairment in hospitalized older adults is often neither accurately identified nor well managed. In conducting a two-phase, comparative-effectiveness clinical trial of the effects of three nursing interventions-augmented standard ca... | 25,251,126 | [
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Role of actin filaments in correlating nuclear shape and cell spreading. | It is well known that substrate properties like stiffness and adhesivity influence stem cell morphology and differentiation. Recent experiments show that cell morphology influences nuclear geometry and hence gene expression profile. The mechanism by which surface properties regulate cell and nuclear properties is only ... | 25,251,154 | [
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A surface coordination network based on copper adatom trimers. | Surface coordination networks formed by co-adsorption of metal atoms and organic ligands have interesting properties, for example regarding catalysis and data storage. Surface coordination networks studied to date have typically been based on single metal atom centers. The formation of a novel surface coordination netw... | 25,251,167 | [
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Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. | The supplementary grading system for brain arteriovenous malformations (AVMs) was introduced in 2010 as a tool for improving preoperative risk prediction and selecting surgical patients. To demonstrate in this multicenter validation study that supplemented Spetzler-Martin (SM-Supp) grades have greater predictive accura... | 25,251,197 | [
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Porous molecular crystals by macrocyclic coordination supramolecules. | In this study, we show how the combination of metal ions, counter-anions and opportunely functionalized and preorganized ligands gives rise to two distinct supramolecular isomers, coordination polymeric chains and hexameric macrocycles. The hexamers then aggregate to form a cubic structure exhibiting permanent micropor... | 25,251,200 | [
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Risk factors for complications of pancreatic extracorporeal shock wave lithotripsy. | Extracorporeal shock wave lithotripsy is recommended as treatment for stones in chronic pancreatitis. The aim of this study was to investigate the risk factors for complications of pancreatic extracorporeal shock wave lithotripsy (P-ESWL). Patients with painful chronic pancreatitis and pancreatic stones (> 5 mm diam... | 25,251,205 | [
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Effect of virtual reality-based rehabilitation on upper-extremity function in patients with brain tumor: controlled trial. | The aim of this study was to evaluate the benefit of virtual reality-based rehabilitation on upper-extremity function in patients with brain tumor. Patients with upper-extremity dysfunction were divided into age-matched and tumor type-matched two groups. The intervention group performed the virtual reality program 30 m... | 25,251,249 | [
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Factors related to injury in youth and adolescent baseball pitching, with an eye toward prevention. | The baseball and medical communities have recognized injuries of the upper extremity associated with the overhead throwing motion and have examined manners in which to reduce risk. The authors examine special features of the adolescent pitcher as compared with skeletally mature pitchers and characteristics of pitch mec... | 25,251,251 | [
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Inpatient rehabilitation experience of children with burn injuries: a 10-yr review of the uniform data system for medical rehabilitation. | This study aimed to describe the pediatric burn inpatient rehabilitation population and short-term functional outcomes using the Uniform Data System for Medical Rehabilitation. This is a secondary analysis of data from the Uniform Data System for Medical Rehabilitation database between 2002 and 2011 included children y... | 25,251,252 | [
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Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus. | Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to L-citrulline and NO in a two-step process involving the intermediate N(ω)-hydroxy-L-arginine (NHA). It was shown that Cpd I is the oxygenating species for L-arginine; the hydroperoxo ferric intermediate is the reactive intermediate with NHA. Methylat... | 25,251,261 | [
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Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells. | Hypoxia-induced inflammation and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) play important roles in the pathological process of hypoxic pulmonary hypertension (HPH). Melatonin possesses anti-inflammatory and antiproliferative properties. However, the effect of melatonin on HPH remains uncl... | 25,251,287 | [
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Anorexia nervosa and body fat distribution: a systematic review. | The aim of this paper was to conduct a systematic review of body fat distribution before and after partial and complete weight restoration in individuals with anorexia nervosa. Literature searches, study selection, method development and quality appraisal were performed independently by two authors, and data was synthe... | 25,251,296 | [
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Clinical significance of presence and extent of extrapancreatic necrosis in acute pancreatitis. | Extrapancreatic necrosis (EPN) alone represents a subgroup of pancreatitis with better outcome than patients with pancreatic parenchymal necrosis (PN). However, data on clinical significance of EPN is limited, and significance of the extent of EPN is not known. Two hundred thirteen patients (136 [63.8%] males; mean age... | 25,251,298 | [
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Expression of corticosteroid-binding globulin CBG in the human heart. | Glucocorticoids are known to be involved in myocardial regeneration and destruction. Cardiomyocytes are mostly devoid of nuclear glucocorticoid receptors (GRs) and it is generally assumed that effects of adrenal steroids in heart are mediated through the mineralocorticoid receptor (MR). Here we used immunocytochemistry... | 25,251,318 | [
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Prognostic factors for advanced-stage human immunodeficiency virus-associated classical Hodgkin lymphoma treated with doxorubicin, bleomycin, vinblastine, and dacarbazine plus combined antiretroviral therapy: a multi-institutional retrospective study. | The treatment and outcomes of patients with human immunodeficiency virus (HIV)-associated Hodgkin lymphoma (HL) continue to evolve. The International Prognostic Score (IPS) is used to predict the survival of patients with advanced-stage HL, but it has not been validated in patients with HIV infection. This was a multi-... | 25,251,326 | [
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Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields. | This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45 µT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs ... | 25,251,337 | [
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Genetic and epigenetic changes in chromosomally stable and unstable progeny of irradiated cells. | Radiation induced genomic instability is a well-studied phenomenon, the underlying mechanisms of which are poorly understood. Persistent oxidative stress, mitochondrial dysfunction, elevated cytokine levels and epigenetic changes are among the mechanisms invoked in the perpetuation of the phenotype. To determine whethe... | 25,251,398 | [
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On-demand shape and size purification of nanoparticle based on surface area. | In order to overcome the serious deficiencies of the traditional aqueous centrifugation method in on-demand purification of metal nanoparticles, we have theoretically and experimentally developed a simple purification method based on the nanoparticles' surface area discrepancy, which can separate particles with the sam... | 25,251,421 | [
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Evaluation of electric field distribution in electromagnetic stimulation of human femoral head. | Electromagnetic stimulation is a common therapy used to support bone healing in the case of avascular necrosis of the femoral head. In the present study, we investigated a bipolar induction screw system with an integrated coil. The aim was to analyse the influence of the screw parameters on the electric field distribut... | 25,251,424 | [
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Sonographic characteristics of thymoma compared with mediastinal lymphoma. | Thymomas are uncommon neoplasms that are typically located in the cranioventral mediastinum in domestic species, which generally affects older animals. Medical records and sonograms of 50 animals diagnosed with either mediastinal thymoma (n = 35) or lymphoma (n = 15) between January 2005 and February 2012 were reviewed... | 25,251,427 | [
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Mechanisms controlling arsenic uptake in rice grown in mining impacted regions in South China. | Foods produced on soils impacted by Pb-Zn mining activities are a potential health risk due to plant uptake of the arsenic (As) associated with such mining. A field survey was undertaken in two Pb-Zn mining-impacted paddy fields in Guangdong Province, China to assess As accumulation and translocation, as well as other ... | 25,251,438 | [
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White and grey matter changes in the language network during healthy aging. | Neural structures change with age but there is no consensus on the exact processes involved. This study tested the hypothesis that white and grey matter in the language network changes during aging according to a "last in, first out" process. The fractional anisotropy (FA) of white matter and cortical thickness of grey... | 25,251,441 | [
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Probing the dynamics of plasmon-excited hexanethiol-capped gold nanoparticles by picosecond X-ray absorption spectroscopy. | Picosecond X-ray absorption spectroscopy (XAS) is used to investigate the electronic and structural dynamics initiated by plasmon excitation of 1.8 nm diameter Au nanoparticles (NPs) functionalised with 1-hexanethiol. We show that 100 ps after photoexcitation the transient XAS spectrum is consistent with an 8% expansio... | 25,251,452 | [
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Effect of nasal speaking valve on speech intelligibility under velopharyngeal incompetence: a questionnaire survey. | Velopharyngeal incompetence is known as a contributing factor to speech disorders. Suwaki et al. reported that nasal speaking valve (NSV) could improve dysarthria by regulating nasal emission utilising one-way valve. However, disease or condition which would be susceptible to treatment by NSV has not been clarified yet... | 25,251,499 | [
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Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis. | Growing evidence indicates that the aberrant expression of microRNAs (miRNAs) contributes to tumor development; however, the function of miRNAs in human hepatocellular carcinoma (HCC) remains largely undefined. In this study, we report that microRNA-422a (miR-422a) is significantly down-regulated in HCC tumor samples a... | 25,251,503 | [
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Narrative making and remaking in the early years: prelude to the personal narrative. | Although very young children are unable to formulate a personal narrative of the life course, their everyday lives are steeped in narratives. Drawing on ethnographic studies in diverse sociocultural worlds, we argue that the early years of life form a vital preamble to the personal narrative. In this phase of life, the... | 25,251,507 | [
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Clinical and economic impact of using generic 7.3-mm cannulated screws at a level II trauma center. | We retrospectively studied the clinical and economic impact of a cost-containment program using high quality generic 7.3-mm screws for fixation of femoral neck fractures and pelvic ring injuries at a level II trauma center. Included in the study were 174 patients with femoral neck fractures or posterior pelvic ring inj... | 25,251,525 | [
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Safe cross-pinning of pediatric supracondylar humerus fractures with a flexion-extension-external rotation technique. | The issue of pin configuration for fixation of displaced supracondylar humerus fractures continues to be controversial. In this article, we report on a large single-surgeon 12-year series in which a flexion-extension-external rotation technique of cross-pinning was used. We retrospectively reviewed all pediatric extens... | 25,251,526 | [
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Eikenella corrodens septic hip arthritis in a healthy adult treated with arthroscopic irrigation and debridement. | We present the case of a seemingly spontaneous septic hip arthritis in a patient with no pertinent medical history. Our patient presented with persistent and worsening sharp lower back pain and underwent arthrocentesis of the hip joint, yielding purulent fluid positive for Eikenella corrodens. Our patient's treatment c... | 25,251,528 | [
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Cannulated screw with solid core insert: stronger than cannulated screws. | We conducted a study to determine if there is a significant difference in ultimate load, yield strength, and fatigue strength between solid core screws and cannulated screws and if a solid core insert placed inside a cannulated screw would have biomechanical effects similar to those of a solid core screw. Five screw de... | 25,251,531 | [
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Displaced ischial stress fracture following revision total hip arthroplasty. | Stress fractures of the ischium are uncommon and are most likely caused by excessive stretching or contracture of the hamstring muscles. In addition, revision total hip arthroplasty (THA) may weaken the ilium, and metabolic bone disease may also contribute to a fracture. Treatment is usually conservative and prognosis ... | 25,251,536 | [
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Oxidized lipids and lysophosphatidylcholine induce the chemotaxis, up-regulate the expression of CCR9 and CXCR4 and abrogate the release of IL-6 in human monocytes. | Lipids through regulation of chronic inflammation play key roles in the development of various diseases. Here, we report that a mixed population of human primary monocytes migrated towards LPC, as well as oxidized linoleic acid isoforms 9-S-HODE, 9-R-HODE and 13-R-HODE. Incubation with 9-R-HODE, 13-R-HODE and LPC resul... | 25,251,539 | [
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Palladium-catalyzed N-nitroso-directed C-H alkoxylation of arenes and subsequent formation of 2-alkoxy-N-alkylarylamines. | A palladium-catalyzed direct ortho-alkoxylation of N-alkyl-N-nitrosoarylamines was developed in which alcohols were used as the alkoxylation reagents and PhI(OAc)2 was employed as the oxidant. The protocol was available for both primary and secondary alcohols. The products were transformed to o-alkoxy-N-alkylanilines e... | 25,251,557 | [
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The Impact of Smoking Bans on Smoking and Consumer Behavior: Quasi-Experimental Evidence from Switzerland. | In this paper, we exploit the progressive implementation of smoking bans in public venues at the state level in Switzerland to evaluate both the direct effects on smoking and the potential unintended consequences of these legislations on consumer behaviors as measured by visiting restaurants/bars and discos ('going out... | 25,251,559 | [
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A chameleon catalyst for nonheme iron-promoted olefin oxidation. | We report the chameleonic reactivity of two nonheme iron catalysts for olefin oxidation with H2O2 that switch from nearly exclusive cis-dihydroxylation of electron-poor olefins to the exclusive epoxidation of electron-rich olefins upon addition of acetic acid. This switching suggests a common precursor to the nucleophi... | 25,251,577 | [
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Extracorporeal life support: experience with 2,000 patients. | This is a review of the University of Michigan experience with extracorporeal life support (ECLS) also known as extracorporeal membrane oxygenation (ECMO). Two thousand patients were managed with ECMO from 1973 to 2010. The first 1,000 patients were reported previously. Of the 2,000 patients, 74% were weaned from ECLS,... | 25,251,585 | [
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Descending motor pathways and cortical physiology after spinal cord injury assessed by transcranial magnetic stimulation: a systematic review. | We performed here a systematic review of the studies using transcranial magnetic stimulation (TMS) as a research and clinical tool in patients with spinal cord injury (SCI). Motor evoked potentials (MEPs) elicited by TMS represent a highly accurate diagnostic test that can supplement clinical examination and neuroimagi... | 25,251,591 | [
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Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. | During the development of sepsis, the complication in central nervous system (CNS), appearing early and frequently relative to other systems, can obviously increase the mortality of sepsis. Moreover, sepsis survivors also accompany long-term cognitive dysfunction, while the ultimate causes and effective therapeutic str... | 25,251,596 | [
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Chimeric murine interferon regulatory factor-2 (IRF-2) binds to IRF-E (IRF binding element), VREβ (virus response element) but not to VREα1. | Interferon regulatory factor-2 (IRF-2) is a multifunctional transcription factor having gene activation, repression and synergistic effect in conjunction with IRF-1. IRF-2 is also involved in type I IFN signalling by repressing INFβ gene. So far, the molecular mechanism of its DNA binding activity remains elusive. We h... | 25,251,598 | [
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Strong spatial structure, Pliocene diversification and cryptic diversity in the Neotropical dry forest spider Sicarius cariri. | The Brazilian Caatinga is part of the seasonally dry tropical forests, a vegetation type disjunctly distributed throughout the Neotropics. It has been suggested that during Pleistocene glacial periods, these dry forests had a continuous distribution, so that these climatic shifts may have acted as important driving for... | 25,251,608 | [
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Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people. | Body mass index (BMI) is a known risk factor for cardiovascular disease and cancer. It is also related to white blood count (WBC) and inflammation. The effects of age and gender on these associations have not been explored. Here we have examined the relationships between BMI and inflammatory parameters/cardiovascular r... | 25,251,663 | [
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Phosphate concentration and arbuscular mycorrhizal colonisation influence the growth, yield and expression of twelve PHT1 family phosphate transporters in foxtail millet (Setaria italica). | Phosphorus (P) is an essential element which plays several key roles in all living organisms. Setaria italica (foxtail millet) is a model species for panacoid grasses including several millet species widely grown in arid regions of Asia and Africa, and for the bioenergy crop switchgrass. The growth responses of S. ital... | 25,251,671 | [
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Reactive transport modeling of thermal column experiments to investigate the impacts of aquifer thermal energy storage on groundwater quality. | Aquifer thermal energy storage (ATES) systems are increasingly being used to acclimatize buildings and are often constructed in aquifers used for drinking water supply. This raises the question of potential groundwater quality impact. Here, we use laboratory column experiments to develop and calibrate a reactive transp... | 25,251,716 | [
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Growth, head growth, and neurocognitive outcome in children born very preterm: methodological aspects and selected results. | In light of the growing number of surviving children born very preterm, there is an increasing focus on their long-term outcomes in terms of growth, metabolic status, and neurocognitive development. Therefore, it is of importance to follow such children from birth onwards with the aim of identifying the causes of atypi... | 25,251,724 | [
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Incidence rate of community-acquired sepsis among hospitalized acute medical patients-a population-based survey. | Sepsis is a frequent cause of admission, but incidence rates based on administrative data have previously produced large differences in estimates. The aim of the study was to estimate the incidence of community-acquired sepsis based on patients' symptoms and clinical findings at arrival to the hospital. Population-base... | 25,251,760 | [
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Abdominal paracentesis drainage ahead of percutaneous catheter drainage benefits patients attacked by acute pancreatitis with fluid collections: a retrospective clinical cohort study. | The efficacy and safety of ultrasound-guided abdominal paracentesis drainage ahead of percutaneous catheter drainage as the new second step of a step-up approach are evaluated. The observed parameters were compared between groups including mortality, infection, organ failure, inflammatory factor levels, indexes of furt... | 25,251,762 | [
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Feeding the critically ill patient. | Critically ill patients are usually unable to maintain adequate volitional intake to meet their metabolic demands. As such, provision of nutrition is part of the medical care of these patients. This review provides detail and interpretation of current data on specialized nutrition therapy in critically ill patients, wi... | 25,251,763 | [
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Impact of root fillings and posts on the diagnostic ability of three intra-oral digital radiographic systems in detecting vertical root fractures. | To evaluate (i) the accuracy of three intra-oral digital systems in detecting vertical root fractures (VRFs); and (ii) the influence of different intracanal conditions (without filling, filled with Gutta-percha and metal or fibreglass post). Forty single-rooted human teeth were decoronated and the root canals prepared.... | 25,251,773 | [
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Tests of the effects of adolescent early alcohol exposures on adult outcomes. | To determine whether early adolescent alcohol use contributes to adult alcohol use, misuse and other adult substance-related and social outcomes. In a longitudinal study of twins assessed at target ages 11, 14 and 24 years, two techniques adjusted for confounding factors: a propensity score (PS) adjusting for the effec... | 25,251,778 | [
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Stress facilitates late reversal learning using a touchscreen-based visual discrimination procedure in male Long Evans rats. | The stress response is essential to the survival of all species as it maintains internal equilibrium and allows organisms to respond to threats in the environment. Most stress research has focused on the detrimental impacts of stress on cognition and behavior. Reversal learning, which requires a change in response stra... | 25,251,839 | [
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Hidden semi-Markov models reveal multiphasic movement of the endangered Florida panther. | Animals must move to find food and mates, and to avoid predators; movement thus influences survival and reproduction, and ultimately determines fitness. Precise description of movement and understanding of spatial and temporal patterns as well as relationships with intrinsic and extrinsic factors is important both for ... | 25,251,870 | [
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Anisotropic growth-induced synthesis of dual-compartment Janus mesoporous silica nanoparticles for bimodal triggered drugs delivery. | Multifunctional dual-compartment Janus mesoporous silica nanocomposites of UCNP@SiO2@mSiO2&PMO (UCNP = upconversion nanoparticle, PMO = periodic mesoporous organosilica) containing core@shell@shell structured UCNP@SiO2@mSiO2 nanospheres and PMO single-crystal nanocubes have been successfully synthesized via a novel... | 25,251,874 | [
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Patellar Tendon Reconstruction in Total Knee Arthroplasty: A New Technique. | Patellar tendon disruption is one of the most dreaded complications following total knee arthroplasty (TKA) impacting both implant function and implant longevity. To overcome the concerns regarding allografts and improve outcomes with augmentation techniques, we describe a technique, which we have successfully used ove... | 25,251,879 | [
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Mechanisms of visual threat detection in specific phobia. | People with anxiety or stress-related disorders attend differently to threat-relevant compared with non-threat stimuli, yet the temporal mechanisms of differential allocation of attention are not well understood. We investigated two independent mechanisms of temporal processing of visual threat by comparing spider-phob... | 25,251,896 | [
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Oxidative Stress Induces Biphasic ERK1/2 Activation in the RPE with Distinct Effects on Cell Survival at Early and Late Activation. | Oxidative stress is considered a major factor in the deterioration of retinal pigment epithelium (RPE) cells in dry age-related macular degeneration (AMD). The MAPK ERK1/2 can be activated by oxidative stress, may exert both pro- and anti-apoptotic functions, and has recently been proposed as a major factor in RPE dege... | 25,251,900 | [
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Engineering complementary hydrophobic interactions to control β-hairpin peptide self-assembly, network branching, and hydrogel properties. | The MAX1 β-hairpin peptide (VKVKVKVK-V(D)PPT-KVKVKVKV-NH2) has been shown to form nanofibrils having a cross-section of two folded peptides forming a hydrophobic, valine-rich core, and the polymerized fibril exhibits primarily β-sheet hydrogen bonding.1-7 These nanofibrils form hydrogel networks through fibril entangle... | 25,251,904 | [
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Accurate ultrasonographic prediction of progesterone concentrations greater than 1 ng/ml in Holstein lactating dairy cows. | To develop an ultrasonographic assay for determining plasma progesterone concentration (P4 ) as < 1 ng/ml or ≥ 1 ng/ml, the corpus luteum (CL) area and P4 were measured in 1094 multiparous Holstein cows. The area-measuring function and frozen images were used to outline and measure CL imaged via ultrasonography, and... | 25,251,911 | [
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Light extraction of trapped optical modes in polymer light-emitting diodes with nanoimprinted double-pattern gratings. | Despite the rapid development of polymer light-emitting diodes (PLEDs), the overall device efficiency is still limited because ∼80% of the generated light is trapped in a conventional device architecture by the high refractive index of organic materials and the optical confinement and internal reflection. The implement... | 25,251,912 | [
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Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. | In the search for effective multifunctional agents for the treatment of Alzheimer's disease (AD), a series of novel hybrids incorporating benzofuran and chalcone fragments were designed and synthesized. These hybrids were screened by using a transgenic Caenorhabditis elegans model that expresses the human β-amyloid (Aβ... | 25,251,917 | [
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Selectfluor and NFSI exo-glycal fluorination strategies applied to the enhancement of the binding affinity of galactofuranosyltransferase GlfT2 inhibitors. | Two complementary methods for the synthesis of fluorinated exo-glycals have been developed, for which previously no general reaction had been available. First, a Selectfluor-mediated fluorination was optimized after detailed analysis of all the reaction parameters. A dramatic effect of molecular sieves on the course of... | 25,251,918 | [
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Current recommendations for monitoring depth of neuromuscular blockade. | Residual neuromuscular block is a relatively frequent occurrence and is associated with postoperative pulmonary complications, including aspiration, pneumonia and hypoxia, impaired hypoxic ventilatory drive and decreased patient satisfaction. Although adequate recovery of neuromuscular function has been defined as a tr... | 25,251,919 | [
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Management of neuromuscular blockade in ambulatory patients. | The use of neuromuscular blocking agents in ambulatory surgery has been described as a double-edged sword. Muscle relaxants may improve the outcome following endotracheal intubation and could be helpful for the surgeon to some extent. However, these agents might increase the risk of postoperative complications because ... | 25,251,920 | [
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Association of time to kidney transplantation with graft failure among U.S. patients with end-stage renal disease due to lupus nephritis. | Providers recommend waiting to transplant patients with end-stage renal disease (ESRD) secondary to lupus nephritis (LN), to allow for quiescence of systemic lupus erythematosus (SLE)-related immune activity. However, these recommendations are not standardized, and we sought to examine whether duration of time to trans... | 25,251,922 | [
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Cost-benefit analysis of the Swiss national policy on reducing micropollutants in treated wastewater. | Contamination of freshwater with micropollutants (MPs) is a growing concern worldwide. Even at very low concentrations, MPs can have adverse effects on aquatic ecosystems and possibly also on human health. Switzerland is one of the first countries to start implementing a national policy to reduce MPs in the effluents o... | 25,251,946 | [
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A new problem in inflammatory bladder diseases: use of mobile phones! | Technological developments provide a lot of conveniences to our lives. This issue is one of the risks that arise along with these conveniences. In our study we tried to understand the impact of electromagnetic waves from mobile phones on bladder tissue. Twenty-one adult male albino rats were divided into three equal gr... | 25,251,956 | [
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Sublingual administration of tacrolimus: current trends and available evidence. | Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature ... | 25,251,980 | [
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The role of phytochemicals as micronutrients in health and disease. | Intake of dietary phytochemicals has frequently been associated with health benefits. Noninfectious diseases including cardiovascular disease (CVD), cancer and diabetes are major causes of death, whereas dementia cases are also increasing to 'epidemic' proportion. This review will focus on recent progress on mechanisms... | 25,252,018 | [
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Left atrial volume index as a predictor for persistent left ventricular dysfunction after aortic valve surgery in patients with chronic aortic regurgitation: the role of early postoperative echocardiography. | This study aimed to explore whether echocardiographic measurements during the early postoperative period can predict persistent left ventricular systolic dysfunction (LVSD) after aortic valve surgery in patients with chronic aortic regurgitation (AR). We prospectively recruited 54 patients (59 ± 12 years) with isolated... | 25,252,020 | [
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Assessment of altered three-dimensional blood characteristics in aortic disease by velocity distribution analysis. | To test the feasibility of velocity distribution analysis for identifying altered three-dimensional (3D) flow characteristics in patients with aortic disease based on 4D flow MRI volumetric analysis. Forty patients with aortic (Ao) dilation (mid ascending aortic diameter MAA = 40 ± 7 mm, age = 56 ± 17 years, 11 females... | 25,252,029 | [
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0.3970328,
-0.1602236... |
Enantioselective all-carbon (4+2) annulation by N-heterocyclic carbene catalysis. | The enantioselective vinylogous Michael/aldol cascade is an underdeveloped approach to cyclohexenes. Herein we describe a highly enantioselective (most ≥ 98:2 er) and diastereoselective (all ≥ 15:1 dr) N-heterocyclic carbene catalyzed cycloisomerization of acyclic dienyl esters to cyclohexyl β-lactones. Derivatizations... | 25,252,043 | [
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0.2414989,
0.07777863,
0.1298832,
0.1296702,
0.121895,
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... |
First pediatric case of Chromobacterium haemolyticum causing proctocolitis. | Bloody diarrhea in children is usually due to either infectious or inflammatory etiology, but infection is far more common than inflammatory bowel disease in children worldwide. If, however, the patient has unfavorable response to antibiotics and a definite infectious agent has yet to be identified; colonoscopy should ... | 25,252,051 | [
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... |
Hypocalcemic cardiomyopathy as initial presentation of primary hypoparathyroidism. | Cardiomyopathy is a rare but life-threatening condition in children. Myocarditis is the leading cause of dilated cardiomyopathy (DCM) and prognosis is generally poor without heart transplantation. We report a rare case of hypocalcemic DCM due to primary hypoparathyroidism in a male infant. In our patient, aggressive ma... | 25,252,065 | [
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0.005846458,
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0.2027035,
-0.3241... |
Case of Desbuquois dysplasia type 1: potentially lethal skeletal dysplasia. | We report a boy with Desbuquois dysplasia type 1. He had the typical skeletal changes: a "Swedish key" appearance of the proximal femora; advanced carpal ossification and other distinctive features of the hand, including an extra-ossification center at the base of the proximal phalanx of the index and middle fingers; d... | 25,252,066 | [
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0.1127212,
0.3879137,
0.2774743,
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0.3... |
Luminescence study and dosimetry approach of Ce on an α-Sr2 P2 O7 phosphor synthesized by a high-temperature combustion method. | We report synthesis of a cerium-activated strontium pyrophosphate (Sr2 P2 O7 ) phosphor using a high-temperature combustion method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), photoluminescence (PL) and thermoluminescence (TL). The XRD pattern reveals that Sr2... | 25,252,077 | [
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0.4627556,
0.1040371,
... |
Acral lentiginous melanoma treated with topical imiquimod cream: possible cooperation between drug and tumour cells. | An 85-year-old woman presented with a lesion on the sole of her right foot, which was histologically confirmed as acral lentiginous melanoma. Because of the large field involved and because the patient refused any invasive or painful treatment, topical treatment with imiquimod was commenced. At the 20-month follow-up, ... | 25,252,087 | [
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0.1358991,
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0.1814584,
0.3025781,
0.1880438,
-0.1208316... |
Reversible CO exchange at platinum(0). An example of similar complex properties produced by ligands with very different stereoelectronic characteristics. | The ligands 1,2-C6H4(CH2P(t)Bu2)2 (La) and 1,2-C6H4(P(t)Bu2)(CH2P(t)Bu2) (Lb) displace norbornene (nbe) from [Pt(η(2)-nbe)3] to give [PtL(η(2)-nbe)] where L = La (1a) or Lb (1b); 1a is fluxional on the NMR timescale. Reaction of 1a,b with CO gives the corresponding monocarbonyls [PtL(CO)] where L = La (2a) or Lb (2b) w... | 25,252,090 | [
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0.2271922,
0.05846243,
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0.1569306,
0.322926,
0.4267053,
0.03697213,
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... |
A cytotoxic and cytostatic gold(III) corrole. | We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of ... | 25,252,099 | [
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0.3271566,
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0.06828158,
0.3022636,
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-0.06312269,
0.... |
Mass selective ion transfer and accumulation in ion trap arrays. | The concept and method for mass selective ion transfer and accumulation within quadrupole ion trap arrays have been demonstrated. Proof-of-concept experiments have been performed on two sets of ion trap arrays: (1) a linear ion trap with axial ion ejection plus a linear ion trap with radial ion ejection; (2) a linear i... | 25,252,102 | [
-0.2770073,
0.2466128,
-0.240005,
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0.1350001,
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0.2023204,
0.1316863,
0.2409621,
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0.02831163,
0.06279409,
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-0.09510335,
0.02964656,
-0.1704301,
0.1570143,
-0.04951786,
-0.05568241... |
Extraction and enrichment of triazole and triazine pesticides from honey using air-assisted liquid-liquid microextraction. | In the present work, an easy, fast, and effective approach is developed for the extraction and enrichment of triazole and triazine pesticides in honey by air-assisted liquid-liquid microextraction coupled with gas chromatography-flame ionization detection. Initially, honey is dissolved in an acetonitrile: water mixture... | 25,252,113 | [
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0.02997947,
0.04264444,
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0.206384,
0.1101139,
0.06615523,
... |
Understanding the role of single molecular ZnS precursors in the synthesis of In(Zn)P/ZnS nanocrystals. | Environmentally friendly nanocrystals (NCs) such as InP are in demand for various applications, such as biomedical labeling, solar cells, sensors, and light-emitting diodes (LEDs). To fulfill their potential applications, the synthesis of such high-quality "green" InP NCs required further improvement so as to achieve b... | 25,252,171 | [
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0.06009458,
0.02771362,
0.5050273,
0.1782136,
0.1491896,
-0.3454111,... |
Regulation of metabolism in individual mitochondria during excitation-contraction coupling. | The heart is an excitable organ that undergoes spontaneous force generation and relaxation cycles driven by excitation-contraction (EC) coupling. A fraction of the oscillating cytosolic Ca(2+) during each heartbeat is taken up by mitochondria to stimulate mitochondrial metabolism, the major source of energy in the hear... | 25,252,178 | [
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-0.1879802,
0.1942089,
0.3499289,
-0.0112515,
... |
Sunitinib-induced hypertension, neutropaenia and thrombocytopaenia as predictors of good prognosis in patients with metastatic renal cell carcinoma. | To evaluate the clinical significance of hypertension (HTN), neutropaenia and thrombocytopaenia as possible new biomarkers of sunitinib efficacy in non-trial patients with metastatic renal cell carcinoma (mRCC). In all, 181 consecutive patients with mRCC were treated with sunitinib; 39 (22%) received sunitinib 50 mg/da... | 25,252,180 | [
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0.4334763,
0.1985626,
0.09963345,
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0.206511,
-0.07981... |
Provider knowledge of trivalent inactivated and high-dose influenza vaccines. | The objective of this study was to assess provider knowledge about trivalent inactivated and high dose influenza vaccines. Hence, a 20-item survey was distributed to providers within the Internal Medicine department at an urban academic medical center. Two hundred and eighty-one (24.5%) providers responded. The correct... | 25,252,197 | [
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0.0331995,
0.1209962,
0.2536582,
0.2293684,
-0.02650552,... |
Modified protocol for improvement of differentiation potential of menstrual blood-derived stem cells into adipogenic lineage. | To characterize potency of menstrual blood-derived stem cells (MenSCs) for future cell therapies, we examined differentiation potential of MenSCs into adipocytes. Differentiation potential of MenSCs in comparison to bone marrow stem cells (BMSCs) was assessed in conventional culture medium. Differentiation potential of... | 25,252,214 | [
0.06551126,
0.03562212,
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0.313492,
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0.0004672037,
0.3578049,
0.3127917,
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... |
Unraveling the effect of arsenic on the model Medicago-Ensifer interaction: a transcriptomic meta-analysis. | The genetic regulation underlying the effect of arsenic (As(III)) on the model symbiosis Medicago-Ensifer was investigated using a combination of physiological (split-roots), microscopy and genetic (microarrays, qRT-PCR and composite plants) tools. Nodulation was very sensitive to As(III) (median inhibitory dose (ID50)... | 25,252,248 | [
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0.2959716,
0.008101302,
0.2451347,
0.2392252,
0.3254037,
-0.233,
-0.1... |
Peripheral ameloblastoma with dystrophic calcification: an unusual feature in non-calcifying odontogenic tumors. | Peripheral ameloblastoma is a rare extraosseous counterpart of central ameloblastoma that occurs in soft tissues and may cause bone crest resorption. This study reports a peripheral ameloblastoma on the buccal gingiva of a 56-year-old man, which presented extensive squamous metaplasia areas, keratinization and dystroph... | 25,252,263 | [
-0.4023194,
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0.2014596,
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Brain activity: connectivity, sparsity, and mutual information. | We develop a new approach to functional brain connectivity analysis, which deals with four fundamental aspects of connectivity not previously jointly treated. These are: temporal correlation, spurious spatial correlation, sparsity, and network construction using trajectory (as opposed to marginal) Mutual Information. W... | 25,252,277 | [
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0.2290052,
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0.1999131,
-0.08045422,
-0.07273448,
-0.1143015,
0.1722482,
0.032848... |
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